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| 14,067 | 14,265 |
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single-stranded RNA virus
| 1,725 | 1,750 |
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The Sphere Handbook, a collection of rights-based guidelines for humanitarian response
| 4,150 | 4,236 |
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Confounding definite assignment of a geographic
point of origin, the 1918 pandemic spread more or less
simultaneously in 3 distinct waves during an z12-month
period in 191871919, in Europe, Asia, and North America
(the first wave was best described in the United States in
March 1918)
| 6,125 | 6,407 |
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microbe is the cause of the disease
| 15,774 | 15,809 |
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a reliable 3D (three dimensional) structure of the target protein
| 3,102 | 3,167 |
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Significantly shorted time from the disease onset to the symptom improvement in treatment (5.10 ± 2.83 days) compared to control group (7.62 ± 2.27 days) (p < 0.05) No significant difference in blood routine improvement, pulmonary chest shadow in chest film improvement and corticosteroid usgae between the 2 groups.
| 18,272 | 18,588 |
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, multiplex reverse transcriptase polymerase chain reaction (RT-PCR)
| 3,806 | 3,874 |
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Chest radiologic changes have been considered the gold standard for defining a pneumonia event
| 5,040 | 5,134 |
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attenuated bacteria, including Escherichia coli, Vibrio cholerae, lactic acid bacteria (LAB), specifically Lactococcus lactis, Mycobacterium, Listeria, Shigella and Salmonella, have been tested for the targeted delivery of heterologous antigens of bacterial, viral and parasitic origin into a variety of animal hosts
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43357,
1315,
341,
9552,
24,
31,
6200,
25,
1472,
11045,
783,
12944,
23,
24325,
12096,
2876,
272,
248,
1052,
275,
267,
19174,
24,
32586,
9407,
363,
14367,
284,
31535,
204,
19,
3927,
26037,
20,
273,
267,
16025,
9407,
1487,
11027,
33353,
31535,
646,
4027,
1241,
62402,
17045,
41868,
965,
204,
19,
93,
57,
14623,
20,
13604,
427,
783,
17436,
25,
10944,
23,
1988,
31670,
24,
10965,
2885,
44871,
646,
4027,
25,
1133,
1945,
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5946,
988,
61891,
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88,
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42453,
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59680,
204,
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10068,
24,
59680,
20,
18341,
2454,
1641,
1241,
783,
266,
18270,
345,
8700,
23825,
646,
4027,
273,
7805,
271,
314,
8979,
273,
2005,
312,
34753,
248,
12596,
3967,
59225,
409,
14623,
25,
2050,
392,
21723,
24,
3039,
44871,
646,
7100,
271,
314,
4301,
416,
736,
312,
267,
886,
22871,
10613,
275,
553,
51,
23724,
23,
480,
614,
312,
1040,
90,
538,
300,
15890,
3069,
4048,
313,
553,
51,
23724,
25,
703,
3358,
4027,
3967,
59225,
11430,
1587,
44871,
1241,
37620,
13514,
8752,
47260,
6429,
204,
19,
28167,
65,
14898,
3039,
34785,
18072
] |
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] |
through the use of serological assays
| 2,565 | 2,602 |
[
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] |
[
1830,
418,
17498,
20343,
314,
8583,
42,
65,
3598,
24,
65,
410,
2033,
24290,
9133,
34021,
23979,
1061,
193,
193,
12659,
7561,
17794,
25,
17747,
6825,
25,
24084,
88,
25,
6298,
83,
25,
16162,
26,
4111,
78,
26,
34067,
26,
7141,
46,
34599,
39894,
33,
26,
193,
193,
40853,
37,
261,
33,
79,
29,
1622,
77,
29,
705,
3828,
79,
47493,
54616,
29,
18637,
7262,
81,
35,
76,
42273,
19822,
22715,
77,
4821,
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193,
193,
43382,
37,
9084,
364,
23,
20797,
317,
14292,
5736,
91,
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302,
25,
5169,
193,
7499,
37,
204,
626,
31,
24,
3739,
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3924,
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40144,
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696,
25,
34314,
27,
26,
97,
42267,
25297,
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34729,
37,
32067,
24,
1546,
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12053,
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9865,
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1223,
909,
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6429,
5758,
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2887,
47921,
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14830,
7782,
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33250,
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27768,
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14327,
5571,
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12792,
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5310,
14810,
325,
9789,
313,
241,
3185,
335,
33250,
23076,
20895,
25,
7947,
23,
629,
304,
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4902,
662,
312,
627,
23,
14379,
11109,
14810,
39567,
1206,
3517,
24,
539,
682,
4425,
271,
3144,
248,
662,
312,
262,
715,
89,
684,
8536,
2009,
275,
16767,
23076,
14810,
25,
2737,
3919,
33435,
6429,
24,
298,
297,
2033,
14810,
362,
267,
15424,
5647,
271,
15613,
272,
34761,
14810,
875,
6429,
32117,
6596,
7863,
6112,
275,
23076,
61527,
23,
830,
427,
11839,
14734,
23076,
17436,
23,
1093,
8960,
272,
248,
4436,
275,
248,
12586,
325,
418,
2413,
9407,
5861,
8511,
25,
529,
1594,
23,
241,
1488,
297,
2033,
9200,
1764,
9526,
4763,
275,
248,
9200,
271,
3370,
275,
33545,
422,
20343,
963,
345,
248,
13930,
18732,
14764,
4425,
427,
23076,
6429,
7228,
25,
10299,
23,
248,
3205,
271,
13990,
28091,
6429,
32117,
271,
4634,
5946,
23076,
14810,
724,
1586,
248,
42513,
2895,
4419,
241,
12656,
9200,
12040,
1542,
455,
23076,
17436,
25,
735,
1856,
451,
2178,
14366,
6429,
24,
298,
297,
2033,
14810,
312,
745,
272,
7305,
23,
16788,
612,
271,
11367,
14810,
273,
248,
39242,
9961,
312,
3645,
38129,
275,
783,
1407,
24,
22443,
23076,
6429,
14810,
25,
193,
193,
5854,
37,
60323,
23076,
304,
241,
7782,
1242,
1375,
8559,
986,
14803,
273,
10972,
14830,
204,
70,
28,
72,
204,
70,
29,
72,
204,
70,
30,
72,
204,
70,
31,
72,
204,
25,
10299,
23,
23076,
7228,
1764,
459,
20983,
59985,
99,
10970,
3062,
3192,
204,
70,
32,
72,
204,
70,
33,
72,
204,
70,
34,
72,
204,
25,
23979,
1061,
1542,
33250,
23076,
20895,
362,
1433,
273,
6110,
15595,
23,
480,
860,
2356,
362,
1102,
1652,
23,
1497,
1958,
20440,
272,
248,
13459,
388,
6839,
2481,
275,
15637,
427,
23076,
6429,
7228,
23,
836,
25,
80,
1702,
248,
2115,
273,
15285,
204,
70,
35,
23,
204,
36,
72,
204,
25,
10744,
4259,
16184,
4214,
23,
23076,
24,
6144,
63483,
362,
4259,
204,
70,
35,
23,
204,
696,
72,
204,
23,
273,
10972,
4800,
7865,
504,
4027,
271,
847,
275,
248,
1855,
3250
] |
[
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induce immunity at sites of inductive immunity to natural infection, in this case the respiratory tract
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168 million people across 50 countries
| 369 | 407 |
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to comprehensively investigate the viral epidemiology of adult RTIs
| 850 | 917 |
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R 0 of SARS was about 2.1 in Hong Kong, China, 2.7 in Singapore, and 3.8 in Beijing, China
| 15,112 | 15,202 |
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] |
ranged from 14% to 45%
| 1,448 | 1,470 |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] |
[
1562,
304,
33457,
14678,
263,
42,
48561,
271,
5946,
9533,
204,
600,
1442,
8767,
273,
627,
8767,
193,
193,
12659,
7561,
17794,
25,
17747,
6825,
25,
24084,
88,
25,
6298,
83,
25,
16162,
26,
4111,
78,
26,
34067,
26,
7141,
46,
35466,
54430,
33,
26,
193,
193,
40853,
37,
204,
32,
79,
27657,
269,
16790,
78,
59920,
79,
38430,
36,
333,
2693,
6991,
56033,
39479,
30,
2548,
41070,
81,
36,
193,
193,
43382,
37,
37549,
363,
2719,
23,
11692,
38,
707,
1195,
1068,
23,
4653,
393,
25,
193,
7499,
37,
204,
905,
27,
24,
3627,
24,
3460,
193,
40144,
37,
204,
696,
25,
7990,
34,
26,
94,
57138,
47214,
54951,
1321,
40440,
31,
193,
34729,
37,
32067,
24,
1546,
193,
193,
12053,
37,
390,
3253,
271,
248,
5946,
9533,
16302,
272,
3603,
8305,
325,
860,
275,
248,
8767,
427,
248,
204,
853,
30,
13372,
21586,
413,
650,
10196,
273,
248,
3253,
6899,
345,
241,
17959,
25,
16444,
596,
2355,
4464,
273,
416,
455,
8767,
413,
650,
4063,
25,
390,
3432,
273,
3502,
3253,
18943,
248,
3591,
2483,
1192,
1202,
1242,
23,
4333,
273,
8353,
635,
267,
16302,
36278,
271,
2549,
313,
3247,
21186,
273,
6931,
571,
25,
390,
19313,
5789,
10196,
272,
3603,
362,
241,
10009,
3537,
271,
1873,
248,
16302,
204,
600,
360,
662,
271,
1576,
525,
12792,
271,
5068,
3476,
273,
3194,
312,
2661,
2863,
272,
248,
2108,
25,
193,
193,
5854,
37,
1440,
204,
2237,
3960,
204,
626,
36,
31909,
272,
241,
4463,
272,
40425,
2681,
23,
3603,
6900,
241,
51096,
275,
2913,
275,
11038,
23964,
204,
19,
4506,
248,
772,
1494,
6935,
388,
325,
601,
313,
204,
928,
3960,
20,
335,
267,
6487,
2483,
271,
241,
1208,
325,
17947,
1929,
5291,
23,
33632,
273,
5632,
271,
248,
1202,
25,
735,
1769,
398,
3713,
271,
248,
2889,
2824,
28983,
204,
19,
36228,
20,
313,
204,
2791,
3960,
204,
70,
28,
2833,
14740,
204,
31,
2927,
23,
431,
204,
2126,
3675,
204,
905,
27,
23,
248,
20713,
998,
26816,
618,
650,
6935,
345,
241,
5946,
9533,
23,
248,
26082,
275,
248,
6429,
618,
650,
5790,
3342,
273,
4002,
23,
11522,
27172,
59676,
6284,
7678,
5918,
618,
650,
4027,
23,
248,
19722,
382,
17,
47,
54900,
618,
650,
17995,
271,
21010,
39739,
23,
248,
39758,
273,
9200,
2138,
273,
241,
8014,
9200,
398,
2923,
312,
4781,
13584,
4906,
25,
16174,
5506,
1242,
8489,
362,
2526,
241,
204,
1425,
27,
2328,
4463,
272,
40425,
272,
204,
696,
1522,
25,
193,
193,
2985,
204,
2126,
3675,
614,
23,
2376,
204,
1223,
2261,
692,
272,
40425,
273,
43200,
6410,
618,
6851,
650,
5394,
272,
23934,
1093,
248,
19722,
618,
6636,
325,
248,
1769,
808,
416,
2035,
314,
11572,
345,
241,
4908,
2824,
15861,
275,
3864,
47958,
204,
19,
59,
3105,
2330,
20,
204,
70,
29,
72,
273,
618,
6010,
658,
2005,
2516,
9621,
25,
390,
19722,
413,
7307,
1649,
248,
6107,
275,
11052,
11746,
388,
15889,
272,
3354,
5596,
10042,
275,
248,
5946,
9533,
273,
413,
2930,
8031,
312,
3354,
14021,
5346,
11746,
388,
26846,
1093,
35399,
325,
3941,
312,
248,
12792,
275,
5346
] |
[
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] |
where a case infected significantly more contacts than the average
| 9,409 | 9,475 |
[
0,
0,
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| 6,507 | 6,560 |
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| 558 | 566 |
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easy to perform and can be conducted in a home environment
| 12,629 | 12,687 |
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to promote, set standards in, and evaluate progress toward better health for people in all countries
| 2,033 | 2,133 |
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by applying JEV, YF, and DV cultures
| 9,606 | 9,642 |
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These factors heighten local inflammation and the infiltration of granulocytes, T-cells and B-cells (Wark and Gibson, 2006; Braciale et al., 2012) . The increased inflammation, in turn, worsens the symptoms of airway diseases.
| 10,603 | 10,829 |
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mucosal exposure to aerosols or by direct contact of abraded skin with infectious material
| 2,592 | 2,682 |
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17371,
5967,
204,
19,
256,
614,
504,
267,
32603,
312,
3047,
272,
17371,
4494,
813,
13584,
3192,
770,
304,
520,
7069,
3713,
272,
2634,
335,
11489,
3783,
273,
304,
520,
1764,
16308,
25,
3892,
2079,
2913,
275,
331,
8494,
413,
650,
8076,
271,
29979,
255,
272,
7228,
12166,
273,
1873,
204,
19,
3691,
46,
20,
272,
7133,
6025,
23,
335,
7122,
204,
423,
204,
16,
275,
455,
6429,
5750,
482,
3713,
2369,
7133,
4862
] |
[
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
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1,
1,
1,
1,
1,
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1,
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1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] |
ranged from 7 % among younger age groups to 40 % among those aged 60 years and above
| 8,955 | 9,039 |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
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1,
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1,
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1,
1,
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1,
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1,
1,
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1,
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1,
1,
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1,
1,
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1,
1,
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1,
1,
1,
1,
1,
1,
1,
1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] |
[
1562,
4040,
9916,
85,
3396,
504,
650,
18377,
42,
26705,
3969,
272,
44337,
6030,
273,
9407,
15837,
193,
193,
12659,
7561,
3076,
84,
25,
3128,
26,
696,
25,
1425,
29,
26,
297,
84,
29,
25,
11282,
32,
193,
193,
40853,
37,
1609,
15541,
6869,
76,
41879,
36,
4448,
36,
469,
10711,
23446,
1067,
80,
32,
79,
26104,
366,
1671,
80,
59178,
8134,
81,
193,
193,
43382,
37,
707,
13843,
23,
13099,
331,
193,
7499,
37,
204,
905,
27,
193,
40144,
37,
204,
696,
25,
1425,
29,
26,
297,
84,
29,
25,
11282,
32,
193,
34729,
37,
32067,
24,
1546,
193,
193,
12053,
37,
16338,
193,
193,
5854,
37,
38574,
446,
23,
3050,
6847,
413,
18377,
241,
4040,
593,
85,
3396,
23,
241,
204,
18,
3531,
1844,
275,
11978,
18,
204,
28,
23,
29,
658,
1499,
23,
1192,
3988,
2857,
39102,
272,
8844,
49874,
1959,
273,
525,
821,
855,
594,
20209,
3665,
679,
248,
13801,
25,
35713,
633,
313,
1959,
6096,
273,
2138,
42412,
788,
3050,
2778,
272,
248,
4352,
275,
2183,
6096,
23,
204,
29,
627,
1202,
273,
2348,
6168,
33398,
273,
10346,
19001,
273,
49338,
6372,
849,
4034,
271,
13765,
21489,
271,
11811,
388,
248,
19419,
10052,
25,
31652,
263,
414,
6288,
23,
248,
1386,
275,
49874,
1959,
14427,
15988,
204,
18,
6357,
87,
957,
18,
9592,
504,
4044,
40628,
23,
510,
204,
7159,
27,
16,
1192,
204,
853,
30,
273,
204,
626,
31,
204,
30,
273,
9637,
271,
5923,
9570,
510,
271,
248,
1652,
1002,
25,
18320,
5941,
431,
248,
9865,
275,
627,
1959,
6651,
23,
345,
779,
345,
5650,
3783,
23,
1458,
273,
599,
15325,
2356,
275,
568,
601,
23,
2515,
3047,
272,
414,
6360,
2151,
451,
18460,
2631,
25,
10744,
3050,
17437,
272,
248,
16409,
1873,
275,
10160,
1935,
273,
13149,
7228,
23,
1539,
21170,
362,
1764,
7607,
271,
1128,
23,
5678,
271,
9909,
273,
13990,
2523,
312,
7865,
24,
1043,
1923,
1206,
59735,
25,
1077,
6753,
431,
248,
2597,
44670,
9407,
3069,
204,
18,
14573,
4475,
18,
273,
53105,
272,
248,
40950,
275,
2845,
601,
23,
248,
33448,
275,
568,
1079,
304,
9064,
1003,
278,
1062,
13348,
312,
627,
3165,
22573,
4663,
273,
248,
39758,
25,
3462,
11153,
4105,
23,
241,
6288,
3548,
2597,
24,
17601,
44337,
21170,
304,
3250,
23350,
25,
529,
414,
15269,
204,
17,
39932,
957,
28366,
1303,
6155,
24267,
23,
295,
22916,
241,
8808,
5356,
25116,
783,
11277,
271,
1849,
627,
23,
3227,
23,
27133,
273,
10905,
44337,
21170,
273,
9407,
8547,
1696,
424,
23,
335,
1216,
248,
27435,
273,
248,
4269,
40660,
271,
7979,
1660,
272,
568,
5650,
1079,
61197,
272,
1744,
25,
193,
193,
31444,
414,
11807,
52,
6155,
24267,
23,
295,
16757,
2498,
783,
2356,
724,
314,
18152,
431,
43994,
32379,
248,
485,
24,
11585,
204,
18,
53422,
94,
18,
275,
17436,
25,
55406,
19915,
22961,
4444,
273,
11522,
27172,
6596,
7865,
271,
2820,
431,
39567,
1206,
12901,
12113,
10399,
25,
2071,
23,
783,
2709,
5652,
8417,
5455,
13149,
6063,
2977,
431,
9995,
19485,
6429,
26082,
8028,
273,
525,
42977,
275,
627,
1150,
25,
295,
12631,
414,
27345,
29399,
248
] |
[
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
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1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
1,
1,
1,
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1,
1,
1,
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1,
1,
1,
1,
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1,
1,
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1,
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1,
1,
1,
1,
1,
1,
1,
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1,
1,
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1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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a 'Valley of Death' 1,2 no less, between broadening strides in fundamental biomedical research and their incommensurate reach into the clinic.
| 292 | 434 |
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circadian rhythms, sleep and behaviour
| 20,200 | 20,238 |
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The value of R 0 was estimated of 2.30 from reservoir to person and 3.58 from person to person which means that the expected number of secondary infections that result from introducing a single infected individual into an otherwise susceptible population was 3.5
| 1,439 | 1,701 |
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susceptible bats (S B ), exposed bats (E B ), infected bats (I B ), and removed bats (R B ).
| 5,425 | 5,517 |
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| 2,958 | 3,017 |
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5.2 days (95% confidence interval [CI]: 4.1-7.0)
| 9,998 | 10,046 |
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MVA has undergone extensive safety testing and shown to be attenuated in severely immunocompromised animals and safe for use in children, adults, elderly, and immunocompromised persons. With extensive pre-clinical data, recombinant MVA vaccines expressing influenza antigens have been tested in clinical trials and been shown to be safe and immunogenic in humans
| 31,858 | 32,220 |
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
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1,
1,
1,
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1,
1,
1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
1,
1,
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1,
1,
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1,
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1,
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1,
1,
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1,
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1,
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1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] |
February 2013
| 3,243 | 3,256 |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
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] |
[
1562,
304,
248,
4614,
26758,
312,
26136,
84,
2598,
4538,
289,
3546,
42,
44,
2014,
24,
1604,
22568,
293,
698,
6063,
94,
7192,
335,
1199,
16026,
388,
241,
10840,
18,
1208,
272,
6508,
193,
193,
12659,
7561,
17794,
25,
17747,
6825,
25,
24084,
88,
25,
6298,
83,
25,
16162,
26,
4111,
78,
26,
34067,
26,
7141,
46,
19248,
50746,
36,
26,
193,
193,
40853,
37,
293,
80,
28,
77,
32,
76,
59608,
35,
79,
516,
33339,
27,
269,
1425,
44291,
1120,
79,
61865,
36,
80,
2423,
7427,
31,
79,
193,
193,
43382,
37,
4149,
250,
23,
531,
2854,
439,
494,
38,
382,
740,
1205,
23,
45644,
132,
93,
2257,
38,
44210,
2771,
23,
55365,
6013,
38,
341,
1925,
23,
9121,
10804,
38,
370,
1819,
23,
6801,
33942,
38,
30911,
54107,
23,
2054,
327,
420,
652,
38,
2431,
11404,
643,
23,
17326,
7936,
38,
531,
6645,
318,
23,
6922,
38,
31510,
10322,
23,
30071,
432,
38,
32507,
24,
66,
1423,
263,
23,
4833,
80,
38,
370,
7973,
17112,
23,
24972,
77,
356,
38,
19459,
60423,
23,
493,
3076,
193,
7499,
37,
204,
853,
33,
24,
696,
24,
3881,
193,
40144,
37,
204,
696,
25,
15711,
33,
26,
20358,
28,
24,
26959,
31,
24,
33,
24,
20358,
193,
34729,
37,
32067,
24,
1546,
193,
193,
12053,
37,
41569,
51834,
37,
529,
1896,
204,
853,
30,
248,
1300,
355,
3402,
2824,
3966,
398,
8398,
275,
267,
39423,
1902,
1386,
275,
2634,
34478,
335,
56848,
604,
23964,
25,
63968,
62,
37,
529,
63778,
11418,
2634,
4708,
1728,
9261,
241,
10840,
18,
1208,
881,
241,
16179,
618,
25435,
269,
25,
3216,
16533,
4906,
7805,
248,
10613,
275,
1199,
16026,
25,
703,
2425,
1783,
1242,
13880,
272,
6508,
271,
2013,
15258,
21298,
1199,
16026,
2634,
569,
618,
9261,
248,
10840,
1208,
25,
1472,
12799,
2481,
4561,
312,
7228,
360,
7819,
241,
1494,
1873,
2220,
204,
19,
28029,
646,
1199,
16026,
2634,
23,
9044,
646,
20975,
5683,
1300,
355,
6810,
20,
273,
241,
24434,
2220,
2369,
13239,
388,
248,
1208,
25,
390,
16179,
26367,
388,
248,
1208,
23,
248,
30264,
427,
585,
334,
27258,
345,
779,
345,
16179,
427,
56705,
3053,
272,
248,
31668,
275,
1300,
355,
646,
7636,
312,
26136,
84,
2598,
4538,
289,
3546,
204,
19,
46,
25,
4538,
289,
3546,
691,
18490,
46403,
37,
317,
2724,
275,
204,
25472,
3713,
1199,
16026,
2913,
398,
8076,
271,
414,
16302,
25,
390,
1726,
44940,
2397,
398,
204,
1868,
1522,
23,
335,
267,
1034,
27233,
558,
2393,
275,
204,
1243,
600,
1463,
1522,
25,
390,
1494,
1873,
2220,
6935,
2469,
22316,
271,
273,
12103,
312,
388,
1931,
241,
1218,
5823,
388,
248,
16179,
18,
94,
3646,
345,
2589,
2481,
4561,
25,
35369,
644,
1574,
7122,
204,
33,
13368,
275,
248,
16179,
18,
94,
3646,
646,
388,
4044,
2481,
312,
3783,
4354,
271,
1014,
3890,
23729,
1514,
25,
3532,
3983,
658,
2589,
2836,
25,
390,
6077,
3033,
2804,
275,
6582,
273,
1770,
398,
8719,
345,
204,
423,
16,
273,
204,
30,
8217,
9403,
23,
204,
1395,
16,
275,
2913,
646,
34478,
25,
390,
293,
698,
325,
618,
25435,
269,
345
] |
[
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
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1,
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1,
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1,
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1,
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1,
1,
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1,
1,
1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
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1,
1,
1,
1,
1,
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1,
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1,
1,
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1,
1,
1,
1,
1,
1,
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1,
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1,
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1,
1,
1,
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1,
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1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] |
sheep, goat and cattle
| 2,634 | 2,656 |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
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1,
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1,
1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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two-dimensional gel electrophoresis , protein chip, mass spectrometry, and suspension array technology
| 2,474 | 2,576 |
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14 were linked to a cluster in Bavaria, Germany, and seven to a cluster in Haute-Savoie, France
| 5,995 | 6,090 |
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infiltration of activated immune cells that further release inflammatory mediators that cause acute symptoms such as increased mucus production, cough, wheeze and shortness of breath.
| 3,739 | 3,922 |
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viral infection in previously healthy children
| 3,931 | 3,977 |
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25,
390,
6107,
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24,
16674,
482,
335,
3381,
35688,
273,
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20268,
541,
275,
13149,
24,
32663,
3783,
362,
11525,
25,
11595,
1565,
271,
3227,
41001,
273,
2579,
6000,
304,
2434,
272,
1958,
24,
273,
4345,
24,
19305,
3354,
23,
1093,
627,
6000,
362,
2434,
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2312,
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29675,
12186,
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1960,
783,
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193,
5854,
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9899,
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5517,
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2084,
2278,
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1770,
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57221,
2397,
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7122,
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1321,
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8719,
204,
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25,
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2261,
1213,
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17437,
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2698,
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23,
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2638,
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10279,
4558,
427,
204,
37977,
2261,
272,
204,
853,
27,
271,
204,
51949,
2261,
272,
204,
626,
32
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1,
1,
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1,
1,
1,
1,
1,
1,
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1,
1,
1,
1,
1,
1
] |
approximately 900,000 of the estimated 6.3 million child deaths in 2013
| 1,438 | 1,509 |
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] |
[
1562,
304,
248,
7100,
2308,
42,
42154,
1587,
9347,
312,
5461,
29080,
8794,
6733,
32225,
275,
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24,
660,
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3603,
193,
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12659,
7561,
3076,
84,
25,
3128,
26,
696,
25,
34314,
27,
26,
85,
6185,
49771,
61325,
31,
193,
193,
40853,
37,
204,
28,
79,
34,
81,
44896,
27,
78,
43887,
31,
20424,
78,
36,
77,
41287,
50988,
80,
34,
1452,
6991,
36,
21981,
6492,
1377,
33,
79,
29,
193,
193,
43382,
37,
1031,
24,
60,
257,
368,
23,
35137,
317,
25,
317,
14292,
399,
698,
255,
23,
26955,
317,
14292,
15660,
23,
11640,
38,
19902,
2346,
9653,
475,
23,
46115,
193,
7499,
37,
204,
905,
27,
193,
40144,
37,
204,
696,
25,
34314,
27,
26,
85,
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an improved adaptive neuro-fuzzy inference system (ANFIS) using an enhanced flower pollination algorithm (FPA) by using the salp swarm algorithm (SSA)
| 788 | 938 |
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50 kDa
| 10,762 | 10,768 |
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2108,
3618,
312,
248,
12166,
273,
2579,
275,
963,
241
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] |
majority of confirmed cases of MERS-CoV were reported among people aged 40 and above
| 11,825 | 11,909 |
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The mean number of days to hospitalisation was 2.5 days for cases imported from China, but 4.6 days for those infected in Europe.
| 6,596 | 6,725 |
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Blockade of C5a complement signaling has also been suggested as a possible option in decreasing inflammation during IAV infection
| 11,233 | 11,362 |
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to explore the feasibility of DNA vaccination of poultry
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autoinfection, but also in infection of patients hospitalised for other causes when they provide care
| 8,828 | 8,929 |
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a substantial proportion of Reunion Island's population had pre-existing immunity to 2009 pandemic influenza virus
| 24,962 | 25,076 |
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Excessive reactive oxygen species (ROS)
| 20,524 | 20,563 |
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mixed respiratory infections and IP-10 may play major, interconnected roles in the pathogenesis of pneumonia
| 23,964 | 24,072 |
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four
| 6,436 | 6,440 |
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homeostasis, differentiation, embryonic development, and organ physiology
| 2,040 | 2,113 |
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7170,
36456,
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362,
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in various forecasting applications, for example, in [23] , a stock price forecasting model was proposed using ANFIS and empirical mode decomposition
| 3,509 | 3,658 |
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according to specific assays targeting at least two separate genes (envelope (E) gene as a screening test and RNA-dependent RNA polymerase (RdRp) gene or nucleoprotein (N) gene for confirmation)
| 8,685 | 8,879 |
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| 4,900 | 4,912 |
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the presence of viral RNA or DNA in the cytoplasm of mammalian cells will induce secretion of type I interferon proteins (IFN-a and IFN-b), which promote expression and translation of interferon-stimulated genes (ISGs) in neighboring cells
| 2,916 | 3,155 |
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1821,
8719,
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2914,
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35,
34021,
23,
6110,
431,
17294,
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54950,
791,
193,
45968,
927
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] |
Persons 65 years of age in 1918 had a dispro-
portionately high influenza incidence
| 23,095 | 23,177 |
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] |
[
1562,
960,
248,
1650,
204,
13,
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484,
10687,
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4059,
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61212,
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7611,
4183,
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1539,
1959,
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2529,
13514,
48314,
2105,
362,
5394,
313,
37,
204,
19,
84,
20,
248,
9233,
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805,
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9200,
14178,
23,
1497,
701,
986,
9407,
5861,
8511,
23,
8301,
31670,
276,
20684,
273,
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18434,
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20220,
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14388,
4468,
8267,
1189,
4678,
11602,
53393,
4183,
2631,
271,
4725,
272,
627,
11033,
23,
4424,
701,
12541,
272,
596,
45755,
23797,
18282,
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15557,
12578,
273,
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5854,
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61212,
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84,
41949,
204,
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7700,
76,
529,
39892,
273,
337,
769,
16157,
3598,
20,
362,
1462,
24,
250,
992,
269,
23,
10811,
24,
18423,
17436,
275,
13493
] |
[
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firstly, early recognition of the deteriorating patient; secondly, HCW safety; thirdly, bystander safety; fourthly, contingency plans for medical emergencies during transport; fifthly, post-transport decontamination
| 2,228 | 2,443 |
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rs12252 C allele
| 34,574 | 34,590 |
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that bat cell lines demonstrated a signature of enhanced interferon-mediated immune response, of either constitutive or induced form, which allowed for establishment of rapid within-host, cell-to-cell virus transmission rates
| 31,802 | 32,027 |
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superoxide dismutase
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enhance the secretion of cytokines and chemokines, such as TNF-, IL-6, IL-8, and IL-12
| 14,834 | 14,920 |
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[
1562,
646,
248,
1386,
275,
2913,
272,
32921,
24378,
345,
275,
3102,
204,
1069,
420,
42,
487,
14729,
20508,
23638,
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660,
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15861,
4426,
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3966,
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12659,
7561,
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12316,
93,
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3128,
26,
23715,
26,
62,
20205,
33,
24,
16562,
27,
19,
423,
20,
24530,
5253,
24,
31,
26,
18331,
193,
22934,
3326,
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Overall, the genome of 2019-nCoV has 89% nucleotide identity with bat SARS-like-CoVZXC21 and 82% with that of human SARS-CoV. The phylogenetic trees of their orf1a/b, Spike, Envelope, Membrane and Nucleoprotein also clustered closely with those of the bat, civet and human SARS coronaviruses.
| 855 | 1,147 |
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zoonotic diseases
| 484 | 501 |
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For HCPS, that expression favors the pulmonary bed and lymphoid organs, yet, for unknown reasons, spares the retroperitoneum and, in general, the kidney. In HFRS the situation is reversed,
| 16,789 | 16,977 |
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principle of modifying the filamentous phage genome to display polypeptides as fusions to coat proteins on the virion surface
| 3,167 | 3,292 |
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| 491 | 518 |
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diminished pulse pressures, tachycardia, and hypotension
| 21,047 | 21,103 |
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antiviral state will be activated to clear the invading pathogen from the airway. Immune response and injury factors released from the infected epithelium normally would induce a rapid type 1 immunity that facilitates viral clearance.
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BRT utilizes regression trees and boosting algorithms to fit several models and combines them for improving prediction by performing iterative loop throughout the model
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[
7282,
30098,
6362,
8584,
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331,
8494,
42,
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9533,
37,
39739,
23,
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273,
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7561,
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17747,
6825,
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88,
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78,
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38800,
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193,
193,
40853,
37,
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33,
81,
13418,
28,
76,
2512,
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6001,
55080,
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52138,
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28,
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469,
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81,
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1622,
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2237,
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60459,
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2245,
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3713,
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49723,
31850,
273,
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23,
8559,
9959,
7418,
13930,
18732,
8056,
272,
701,
42776,
26758,
273,
34167,
31902,
23,
480,
6976,
5241,
2079,
11576,
25,
33213,
63439,
672,
6429,
5851,
871,
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5517,
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2245,
345,
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3089,
13930,
18732,
204,
19,
55,
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20,
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10121,
16026,
23,
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12944,
273,
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325,
724,
3913,
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13241,
13930,
18069,
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959,
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758,
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13241,
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770,
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3575,
24,
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2227,
7074,
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504,
1428,
16616,
23,
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520,
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6554,
273,
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17371,
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256,
614,
504,
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32603,
312,
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4494,
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3192,
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2079,
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275,
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8494,
413,
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8076,
271,
29979,
255,
272,
7228,
12166,
273,
1873,
204,
19,
3691,
46,
20,
272,
7133,
6025,
23,
335,
7122,
204,
423,
204,
16,
275,
455,
6429,
5750,
482,
3713,
2369,
7133,
4862,
204,
19,
16743,
52047
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] |
Older males
| 1,414 | 1,425 |
[
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1,
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1,
1,
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] |
[
1830,
866,
304,
248,
3715,
1192,
248,
2079,
13372,
24,
12443,
24,
29,
273,
248,
7717,
8704,
62553,
1313,
24,
12443,
42,
2749,
26582,
3941,
6921,
5603,
275,
248,
13584,
7727,
275,
13372,
24,
12443,
24,
29,
193,
193,
12659,
7561,
17794,
25,
17747,
6825,
25,
24084,
88,
25,
6298,
83,
25,
16162,
26,
4111,
78,
26,
34067,
26,
7141,
46,
41981,
47457,
32,
26,
193,
193,
40853,
37,
204,
32,
76,
48243,
31,
76,
1452,
44091,
3091,
2034,
35,
81,
27755,
5768,
77,
34,
77,
9890,
36,
77,
49764,
8193,
29,
79,
1463,
193,
193,
43382,
37,
27830,
23,
17761,
24,
40087,
38,
5832,
340,
23,
19982,
462,
14292,
44068,
23,
16755,
382,
14292,
1812,
23,
393,
678,
257,
193,
7499,
37,
204,
905,
27,
24,
3627,
24,
2126,
193,
40144,
37,
204,
696,
25,
10598,
27,
26,
19467,
26521,
6559,
25,
905,
27,
25,
21171,
35450,
27,
193,
34729,
37,
32067,
24,
1546,
193,
193,
12053,
37,
16338,
193,
193,
5854,
37,
390,
27768,
273,
16302,
275,
241,
9930,
6524,
13241,
13930,
3783,
272,
40425,
23,
3603,
23,
504,
6827,
4385,
661,
204,
1738,
23,
1321,
692,
23,
273,
6109,
520,
661,
204,
28,
23,
1321,
345,
275,
3458,
25,
204,
696,
23,
204,
905,
27,
25,
317,
627,
2079,
9533,
23,
13372,
24,
12443,
24,
29,
23,
398,
2976,
6935,
23,
273,
248,
4071,
3783,
304,
849,
8659,
271,
345,
9533,
3783,
6524,
272,
204,
626,
36,
204,
19,
18823,
24,
660,
20,
204,
19,
12659,
7561,
20908,
77,
2123,
761,
1305,
25,
371,
26,
2700,
286,
24,
7873,
7676,
24,
78,
7896,
24,
660,
24,
610,
268,
26,
691,
193,
193,
6925,
271,
637,
504,
650,
3713,
204,
70,
28,
72,
204,
70,
29,
72,
204,
70,
30,
72,
204,
23,
3530,
24,
626,
36,
2748,
271,
413,
2661,
6077,
36858,
271,
325,
275,
248,
6362,
13241,
13930,
13248,
204,
19,
48561,
20,
5229,
431,
13372,
24,
12443,
25,
390,
13372,
24,
12443,
24,
29,
26082,
10277,
614,
504,
18842,
132,
2423,
16,
6947,
335,
13372,
24,
12443,
23,
480,
334,
304,
758,
2661,
271,
596,
7717,
13220,
24,
7873,
7170,
36456,
23,
335,
248,
5123,
1003,
204,
41,
9756,
16,
6947,
204,
70,
31,
23,
204,
32,
72,
204,
25,
193,
193,
21660,
23,
629,
362,
982,
5630,
23,
51704,
273,
20770,
16163,
325,
13372,
24,
12443,
24,
29,
304,
275,
13584,
8332,
25,
2660,
692,
413,
14084,
325,
248,
2079,
13372,
24,
12443,
24,
29,
398,
29042,
3644,
427,
241,
13584,
272,
40425,
881,
241,
7717,
2004,
65,
204,
19,
30409,
62553,
1313,
20,
398,
3358,
3713,
23,
585,
4641,
18842,
132,
9756,
16,
4225,
1303,
335,
248,
13372,
24,
12443,
24,
29,
204,
70,
31,
72,
204,
25,
2071,
23,
345,
360,
655,
23,
248,
2079,
13372,
24,
12443,
273,
21819,
2597,
14778,
12846,
289,
13372,
3470,
2004,
65,
4641,
204,
2512,
25,
35,
16,
4225,
1303,
23,
335,
241,
2724,
275,
204,
905,
2278,
24,
89,
28754,
42557,
204,
19,
404,
20,
14233,
204,
19,
36455,
31467,
20,
6935,
1993,
248,
26082,
204,
70
] |
[
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] |
greater than 1,100 nt
| 1,639 | 1,660 |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] |
[
1562,
379,
81,
35,
4198,
441,
6823,
13372,
24,
12443,
94,
13982,
427,
2304,
24,
28210,
2634,
23,
455,
12846,
289,
13372,
24,
12443,
94,
23,
273,
599,
7717,
13372,
24,
6144,
2004,
31467,
4020,
42,
11180,
9719,
34188,
275,
248,
204,
626,
36,
5946,
2079,
24,
4168,
15824,
9533,
13982,
427,
241,
4110,
335,
56848,
604,
23964,
852,
7809,
40425,
193,
193,
12659,
7561,
17794,
25,
17747,
6825,
25,
24084,
88,
25,
6298,
83,
25,
16162,
26,
4111,
78,
26,
34067,
26,
7141,
46,
44452,
18691,
31,
26,
193,
193,
40853,
37,
253,
3614,
34,
76,
35,
76,
36,
76,
44903,
79,
6186,
78,
3317,
81,
696,
80,
32,
78,
30,
20424,
35070,
660,
80,
27895,
47214,
76,
193,
193,
43382,
37,
20658,
23,
36413,
45113,
24,
66,
443,
38,
43185,
23,
23884,
24,
57427,
38,
50843,
23,
53829,
38,
43078,
23,
32401,
38,
1472,
23,
19406,
5500,
33277,
24,
66,
642,
38,
40704,
23,
61953,
1487,
1272,
38,
551,
9964,
23,
30325,
1264,
24,
68,
1018,
193,
7499,
37,
204,
905,
27,
24,
3091,
24,
2086,
193,
40144,
37,
204,
696,
25,
10598,
27,
26,
19467,
26521,
6559,
25,
905,
27,
25,
20850,
30825,
29,
193,
34729,
37,
32067,
24,
1546,
193,
193,
12053,
37,
317,
17361,
16302,
275,
56848,
604,
23964,
272,
3297,
204,
626,
36,
398,
31907,
271,
241,
23304,
20847,
1208,
272,
40425,
275,
3603,
25,
14740,
241,
1218,
2927,
23,
241,
5946,
9533,
8568,
4489,
5200,
345,
204,
626,
36,
5946,
9533,
204,
19,
626,
36,
24,
89,
12443,
20,
398,
4734,
431,
248,
2889,
2824,
13394,
25,
703,
6016,
11602,
58366,
3549,
313,
241,
6429,
26082,
427,
241,
4110,
335,
204,
626,
36,
24,
89,
12443,
7228,
273,
4354,
334,
335,
599,
3236,
9533,
2375,
2595,
25,
16866,
23,
248,
26082,
275,
204,
626,
36,
24,
89,
12443,
504,
204,
8035,
16,
64784,
6947,
335,
7717,
13372,
24,
3470,
24,
12443,
69,
67,
46,
1868,
273,
204,
10330,
16,
335,
325,
275,
2079,
13372,
24,
12443,
25,
390,
53818,
4655,
6245,
275,
525,
379,
81,
28,
76,
26,
77,
23,
44621,
23,
1800,
55538,
23,
4933,
45839,
273,
409,
28754,
56175,
614,
36281,
1263,
8285,
335,
1014,
275,
248,
7717,
23,
12846,
289,
273,
2079,
13372,
1142,
7170,
36456,
25,
2071,
23,
248,
7341,
1072,
20856,
275,
44621,
329,
94,
19639,
12695,
7281,
275,
204,
626,
36,
24,
89,
12443,
7642,
736,
204,
1738,
16,
20601,
6434,
6947,
335,
599,
13372,
24,
6144,
1142,
7170,
36456,
25,
3848,
628,
1517,
23,
701,
379,
81,
30,
77,
1889,
3472,
241,
3259,
5946,
1866,
6078,
25,
10944,
23,
701,
627,
379,
81,
35,
2486,
1889,
3472,
241,
4865,
269,
6078,
335,
267,
17056,
24,
2776,
939,
23,
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the 1918
pandemic was different in degree, but not in kind, from
previous and subsequent pandemics. Despite the extraordi-
nary number of global deaths, most influenza cases in
1918 (>95% in most locales in industrialized nations) were
mild and essentially indistinguishable from influenza cases
today.
| 26,867 | 27,167 |
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the agents of the more severe forms of HFRS and HCPS have begun to achieve sufficient mass
| 16,586 | 16,676 |
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1-substituted pyridylimidazo[1,5-a]pyridine derivatives
| 22,962 | 23,017 |
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] |
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