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Although the likelihood of coinfection of 2019-nCoV and another respiratory virus is thought to be low, a positive finding of another respiratory pathogen does not exclude the diagnosis of 2019-nCoV
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single-stranded RNA virus
1,725
1,750
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The Sphere Handbook, a collection of rights-based guidelines for humanitarian response
4,150
4,236
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Confounding definite assignment of a geographic point of origin, the 1918 pandemic spread more or less simultaneously in 3 distinct waves during an z12-month period in 191871919, in Europe, Asia, and North America (the first wave was best described in the United States in March 1918)
6,125
6,407
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microbe is the cause of the disease
15,774
15,809
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a reliable 3D (three dimensional) structure of the target protein
3,102
3,167
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Significantly shorted time from the disease onset to the symptom improvement in treatment (5.10 ± 2.83 days) compared to control group (7.62 ± 2.27 days) (p < 0.05) No significant difference in blood routine improvement, pulmonary chest shadow in chest film improvement and corticosteroid usgae between the 2 groups.
18,272
18,588
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mid-nasal nylon flocked
6,206
6,229
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, multiplex reverse transcriptase polymerase chain reaction (RT-PCR)
3,806
3,874
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Chest radiologic changes have been considered the gold standard for defining a pneumonia event
5,040
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H275Y
14,705
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for bacterial vectors there can in fact, in some cases, be an enhancement in immunogenicity, typically humoral, while for viral vectors pre-existing immunity is a hindrance for subsequent induction of cell-mediated responses.
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Providing the limited healthcare worker cadre with appropriate training and personal protective equipment, and ensuring a continuous supply chain
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attenuated bacteria, including Escherichia coli, Vibrio cholerae, lactic acid bacteria (LAB), specifically Lactococcus lactis, Mycobacterium, Listeria, Shigella and Salmonella, have been tested for the targeted delivery of heterologous antigens of bacterial, viral and parasitic origin into a variety of animal hosts
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through the use of serological assays
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induce immunity at sites of inductive immunity to natural infection, in this case the respiratory tract
42,835
42,938
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168 million people across 50 countries
369
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to comprehensively investigate the viral epidemiology of adult RTIs
850
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30,847 nucleotides
1,873
1,891
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January 30, 2020
7,759
7,775
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MicroRNAs (miRNAs)
29,025
29,043
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Retroviruses
731
743
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R 0 of SARS was about 2.1 in Hong Kong, China, 2.7 in Singapore, and 3.8 in Beijing, China
15,112
15,202
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ranged from 14% to 45%
1,448
1,470
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where a case infected significantly more contacts than the average
9,409
9,475
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Rhinovirus (RV) and respiratory syncytial virus (RSV)
6,507
6,560
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7.5 days
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easy to perform and can be conducted in a home environment
12,629
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to promote, set standards in, and evaluate progress toward better health for people in all countries
2,033
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by applying JEV, YF, and DV cultures
9,606
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These factors heighten local inflammation and the infiltration of granulocytes, T-cells and B-cells (Wark and Gibson, 2006; Braciale et al., 2012) . The increased inflammation, in turn, worsens the symptoms of airway diseases.
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mucosal exposure to aerosols or by direct contact of abraded skin with infectious material
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ranged from 7 % among younger age groups to 40 % among those aged 60 years and above
8,955
9,039
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a 'Valley of Death' 1,2 no less, between broadening strides in fundamental biomedical research and their incommensurate reach into the clinic.
292
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circadian rhythms, sleep and behaviour
20,200
20,238
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The value of R 0 was estimated of 2.30 from reservoir to person and 3.58 from person to person which means that the expected number of secondary infections that result from introducing a single infected individual into an otherwise susceptible population was 3.5
1,439
1,701
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heavy (R6K6)
9,674
9,686
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susceptible bats (S B ), exposed bats (E B ), infected bats (I B ), and removed bats (R B ).
5,425
5,517
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an attenuated, temperature-sensitive strain of type II FIPV
2,958
3,017
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5.2 days (95% confidence interval [CI]: 4.1-7.0)
9,998
10,046
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MVA has undergone extensive safety testing and shown to be attenuated in severely immunocompromised animals and safe for use in children, adults, elderly, and immunocompromised persons. With extensive pre-clinical data, recombinant MVA vaccines expressing influenza antigens have been tested in clinical trials and been shown to be safe and immunogenic in humans
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an altered inflammatory state contributing to further viral persistence and exacerbation of chronic airway inflammatory diseases
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February 2013
3,243
3,256
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sheep, goat and cattle
2,634
2,656
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two-dimensional gel electrophoresis , protein chip, mass spectrometry, and suspension array technology
2,474
2,576
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14 were linked to a cluster in Bavaria, Germany, and seven to a cluster in Haute-Savoie, France
5,995
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infiltration of activated immune cells that further release inflammatory mediators that cause acute symptoms such as increased mucus production, cough, wheeze and shortness of breath.
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viral infection in previously healthy children
3,931
3,977
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approximately 900,000 of the estimated 6.3 million child deaths in 2013
1,438
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an improved adaptive neuro-fuzzy inference system (ANFIS) using an enhanced flower pollination algorithm (FPA) by using the salp swarm algorithm (SSA)
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50 kDa
10,762
10,768
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majority of confirmed cases of MERS-CoV were reported among people aged 40 and above
11,825
11,909
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The mean number of days to hospitalisation was 2.5 days for cases imported from China, but 4.6 days for those infected in Europe.
6,596
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Blockade of C5a complement signaling has also been suggested as a possible option in decreasing inflammation during IAV infection
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to explore the feasibility of DNA vaccination of poultry
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autoinfection, but also in infection of patients hospitalised for other causes when they provide care
8,828
8,929
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a substantial proportion of Reunion Island's population had pre-existing immunity to 2009 pandemic influenza virus
24,962
25,076
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Excessive reactive oxygen species (ROS)
20,524
20,563
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mixed respiratory infections and IP-10 may play major, interconnected roles in the pathogenesis of pneumonia
23,964
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homeostasis, differentiation, embryonic development, and organ physiology
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in various forecasting applications, for example, in [23] , a stock price forecasting model was proposed using ANFIS and empirical mode decomposition
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according to specific assays targeting at least two separate genes (envelope (E) gene as a screening test and RNA-dependent RNA polymerase (RdRp) gene or nucleoprotein (N) gene for confirmation)
8,685
8,879
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BatCoV HKU10
4,900
4,912
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the presence of viral RNA or DNA in the cytoplasm of mammalian cells will induce secretion of type I interferon proteins (IFN-a and IFN-b), which promote expression and translation of interferon-stimulated genes (ISGs) in neighboring cells
2,916
3,155
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Persons 65 years of age in 1918 had a dispro- portionately high influenza incidence
23,095
23,177
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a diverse pool of recombinant filamentous phage displaying an array of polypeptide variants (e.g., antibody fragments; peptides)
8,797
8,925
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firstly, early recognition of the deteriorating patient; secondly, HCW safety; thirdly, bystander safety; fourthly, contingency plans for medical emergencies during transport; fifthly, post-transport decontamination
2,228
2,443
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rs12252 C allele
34,574
34,590
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birds
2,226
2,231
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that bat cell lines demonstrated a signature of enhanced interferon-mediated immune response, of either constitutive or induced form, which allowed for establishment of rapid within-host, cell-to-cell virus transmission rates
31,802
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an extraordinary event which is determined to constitute a public health risk to other States through the international spread of disease and to potentially require a coordinated international response
2,740
2,941
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superoxide dismutase
11,390
11,410
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enhance the secretion of cytokines and chemokines, such as TNF-, IL-6, IL-8, and IL-12
14,834
14,920
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80,793
4,738
4,744
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the low transmission rate
29,995
30,020
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Overall, the genome of 2019-nCoV has 89% nucleotide identity with bat SARS-like-CoVZXC21 and 82% with that of human SARS-CoV. The phylogenetic trees of their orf1a/b, Spike, Envelope, Membrane and Nucleoprotein also clustered closely with those of the bat, civet and human SARS coronaviruses.
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primarily by Aedes aegypti, the infamous yellow fever propagator
1,557
1,621
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seven
2,172
2,177
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For HCPS, that expression favors the pulmonary bed and lymphoid organs, yet, for unknown reasons, spares the retroperitoneum and, in general, the kidney. In HFRS the situation is reversed,
16,789
16,977
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principle of modifying the filamentous phage genome to display polypeptides as fusions to coat proteins on the virion surface
3,167
3,292
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Respiratory virus infection
491
518
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diminished pulse pressures, tachycardia, and hypotension
21,047
21,103
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plasma viral RNA with
15,425
15,446
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antiviral state will be activated to clear the invading pathogen from the airway. Immune response and injury factors released from the infected epithelium normally would induce a rapid type 1 immunity that facilitates viral clearance.
14,396
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BRT utilizes regression trees and boosting algorithms to fit several models and combines them for improving prediction by performing iterative loop throughout the model
25,944
26,112
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Older males
1,414
1,425
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greater than 1,100 nt
1,639
1,660
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fulllength orf8
11,480
11,495
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the 1918 pandemic was different in degree, but not in kind, from previous and subsequent pandemics. Despite the extraordi- nary number of global deaths, most influenza cases in 1918 (>95% in most locales in industrialized nations) were mild and essentially indistinguishable from influenza cases today.
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the agents of the more severe forms of HFRS and HCPS have begun to achieve sufficient mass
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United Kingdom (UK)
2,861
2,880
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1-substituted pyridylimidazo[1,5-a]pyridine derivatives
22,962
23,017
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