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10.1038/s41467-018-05870-6 | Biology_easy_328 | "This allows us to explore the potential of finding a novel therapeutic approach that alters energy balance in obesity and modulates the associated diseases." | In the presence of oligomycin, Ago2-deficient hepatocytes showed a higher increase in ECAR compared to controls (Fig. | "Although this is still basic science, we propose that there may be important translational implications for our findings for chronic metabolic disorders like diabetes, fatty liver diseases, and other obesity associated illnesses," said Nakamura, senior investigator and a member of the Division of Endocrinology. "This allows us to explore the potential of finding a novel therapeutic approach that alters energy balance in obesity and modulates the associated diseases." Novel Science
The scientists caution the research is early stage. | Glucose production was similarly induced between genotypes (Fig. In the presence of oligomycin, Ago2-deficient hepatocytes showed a higher increase in ECAR compared to controls (Fig. Upon the addition of the protonophore carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone (FCCP), Ago2-deficient hepatocytes greatly upregulated oxygen consumption compared to WT controls (Fig. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=37060860200&p=1pl&v=1&x=8Lal0RIMgLlUZpQnXZ6jPQ |
10.1038/s41467-018-05870-6 | Biology_easy_329 | He pointed out that disruption of these events is already a common feature in obesity and its related illnesses. | Consistent with enhanced capacity for energy production in Ago2-deficiency (Fig. | But the current paper provides a solid basis for subsequent work. Nakamura said that identifying Ago2's role in the process "connects the dots" between how proteins are translated in the liver, how energy is produced and consumed and the activity of AMPK in these processes. He pointed out that disruption of these events is already a common feature in obesity and its related illnesses. | These observations suggest that enhanced protein synthesis in the liver may result in a lowered ATP/ADP ratio and AMPK activation in L-Ago2 KO mice. Consistent with enhanced capacity for energy production in Ago2-deficiency (Fig. 2g) , relative ATP/ADP levels were higher in Ago2-deficient hepatocytes compared to controls, however, the levels were rapidly decreased post-metformin treatment, suggesting a higher energy consumption rate in Ago2-deficiency (Fig. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=37060860200&p=1pl&v=1&x=8Lal0RIMgLlUZpQnXZ6jPQ |
10.1126/science.1256773 | Biology_easy_330 | This cell-free system has two huge advantages: It expands the scale of the furrow-building events, making them easier to see, and it gives the researchers an easy way to manipulate the proteins involved. | Live imaging showed partial colocalization of CPC and Kif4A movement ( fig. | It's hard to see and test such a complex feat in living cells. This cell-free system has two huge advantages: It expands the scale of the furrow-building events, making them easier to see, and it gives the researchers an easy way to manipulate the proteins involved. Quickly removing and returning proteins to see how changes in the molecular players affect cytokinesis is impossible when the cell is whole, but easy when the cellular innards are spread out on a microscope slide. | Kif4A depletion blocked CPC movement, and addback of recombinant Kif4A rescued it (Fig. Live imaging showed partial colocalization of CPC and Kif4A movement ( fig. Thus, the CPC is targeted to the AAIZ and transported to a narrow band by the combined action of Kif20AE and Kif4A. | [1] | Biology | train | 1 | news | http://www.science20.com/news_articles/cytokinesis_lite_cellular_division_now_with_no_cells-148202 |
10.1038/ncomms4999 | Biology_easy_331 | Most remarkably, the ringing involves the entire protein, meaning the ringing motion could be responsible for the transfer of energy across proteins. | As the damping g is less than the frequency o 0 , this implies that the vibrational mode involves an underdamped oscillator. | They discovered that this enzyme rings like a bell with a frequency of a few terahertz or a million-million hertz. Most remarkably, the ringing involves the entire protein, meaning the ringing motion could be responsible for the transfer of energy across proteins. The experiments show that the ringing motion lasts for only a picosecond or one millionth of a millionth of a second. | 1 ), yielding the parameters o 0 ¼ 1.15 THz and g ¼ 0.52 THz for the broad shoulder and o 0 ¼ 2.80 THz and g ¼ 1.24 THz for the narrow peak. As the damping g is less than the frequency o 0 , this implies that the vibrational mode involves an underdamped oscillator. If the solvated-protein spectrum in the terahertz range were due to multiple localized modes, one would expect an inhomogeneous gaussian distribution of local-mode frequencies-reflecting different local masses and forces-giving rise to a broad overdamped spectrum. | [1] | Biology | train | 1 | news | http://www.sciencedaily.com/releases/2014/06/140603092424.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1016/j.neuron.2014.05.028 | Biology_easy_332 | The finding may accelerate the development of treatments for preventing PTSD (post-traumatic stress disorder). | More studies about this topic would be desirable to further understand the mechanisms of the Tac2/ NkB/Nk3R pathway. | The finding may accelerate the development of treatments for preventing PTSD (post-traumatic stress disorder). "PTSD is unique among psychiatric disorders in that we know when it starts -- at the time of the trauma. Out of thousands of genes they examined, their "top gene" was Tachykinin 2 or Tac2. | To the best of our knowledge, this is the first evidence that a neuronal population specifically highly expressed in the CeM, Tac2 and its product NkB peptide, are required for the modulation of fear memory consolidation affecting neither unconditioned fear nor anxiety-like behavior. More studies about this topic would be desirable to further understand the mechanisms of the Tac2/ NkB/Nk3R pathway. Our findings also suggest that CeA-Tac2 lentiviral overexpression enhances fear memory consolidation but Nk3R antagonism prevents it. | [1] | Biology | train | 1 | news | http://www.sciencedaily.com/releases/2014/06/140630124423.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1016/j.immuni.2019.05.007 | Biology_easy_334 | With this knowledge, vaccine developers will have a better understanding of how, and how often, to reformulate the vaccine over time. | antibodies (7.1 ± 0.5% mean rate of somatic hypermutation) were slightly less mutated than the pre-existing antibodies (8.2 ± 1.1%), this difference did not reach statistical significance. | A human antibody that can target these highly conserved areas will provide broad protection for a prolonged period of time. With this knowledge, vaccine developers will have a better understanding of how, and how often, to reformulate the vaccine over time. The technology, developed by co-author George Georgiou, was used to discover the key antibody in the study and the approach is applicable to a variety of highly variable bacteria and viruses. | Although emergent Table S1 . antibodies (7.1 ± 0.5% mean rate of somatic hypermutation) were slightly less mutated than the pre-existing antibodies (8.2 ± 1.1%), this difference did not reach statistical significance. The anti-GII.4c serological repertoire was predominantly comprised of antibodies using the immunoglobulin heavy variable 3 (IGHV3) family ($80%; Figure 1F ) compared to $30% in naive or mature B cells Mroczek et al., 2014) . | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=39490550792&p=1pl&v=1&x=jZsW-0WrF4cY8V2Qpk9zfA |
10.1016/j.cell.2018.04.034 | Biology_easy_335 | In contrast, they found that CDK12-mutated mCRPC tumors exhibited a "distinctive genomic landscape" that was similar to that identified in a subset of ovarian cancers. | In addition to the singleton outlier RTKs ( Figure S6C ), we found two cases of BRAF fusions (KIAA1549-BRAF and HIPK2-BRAF) generated as a result of a CDK12-FTD ( Figures S6D and S6E ). | "All patients showed biallelic inactivation of CDK12," they note, while "strikingly," the CDK12 mutations were mutually exclusive to all of the already known primary genetic drivers (PGDs) analysed, including ETS fusions, SPOP mutations, HRD (homologous recombination-deficiency, ATM mutations and mismatch repair-deficiency (MMRD)." In contrast, they found that CDK12-mutated mCRPC tumors exhibited a "distinctive genomic landscape" that was similar to that identified in a subset of ovarian cancers. "The prototype CDK12 mutant tumor was baseline diploid and had few arm-level copy-number aberrations except gain of 8q, but notably, hundreds of focal copy-number gains were dispersed across the gnome," they state. | All other PGDs had signatures dominated by translocations (49%) and fewer overall duplications (11%) than deletions (18%) or inversions (22%), further supporting the uniqueness of CDK12 mutant PCa. In addition to the singleton outlier RTKs ( Figure S6C ), we found two cases of BRAF fusions (KIAA1549-BRAF and HIPK2-BRAF) generated as a result of a CDK12-FTD ( Figures S6D and S6E ). Surprisingly, we also found a promoter hijacking event leading to outlier expression of ETV1 ( Figure S6F ). | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34304544254&p=1pl&v=1&x=4ldt3u_6ItGR2RE2UuBujA |
10.1098/rspb.2013.3276 | Biology_easy_336 | That's the conclusion of a study published this week in the Proceedings of the Royal Society B, which helps explain how marine communities that depend on isolated methane sources manage to colonize far-flung regions. | mauritanicus via widespread larval dispersal . | That's the conclusion of a study published this week in the Proceedings of the Royal Society B, which helps explain how marine communities that depend on isolated methane sources manage to colonize far-flung regions. Surface currents, however, move much faster and could potentially carry the larvae across this distance in time. The larvae of two seep-dwellers--a mussel and a small sea snail--were both found in shallow waters. | These genetic findings support a hypothesis of infrequent or historical connectivity of "B." mauritanicus via widespread larval dispersal . For "B." | [1] | Biology | train | 1 | news | http://news.sciencemag.org/environment/2014/05/scienceshot-surface-currents-spread-deep-sea-seep-species |
10.1038/s41568-018-0020-9 | Biology_easy_337 | I look forward to seeing how the combination of these therapies can affect outcomes in patients for whom this resistance is associated with poor prognoses." | Therefore, we suggest that HSP90, per se, is not a target in cancer, in the sense that tumours become addicted to HSP90 only when HSP90 becomes integrated into epichaperome networks, potentially explaining the poor performance of HSP90 inhibitors in non-selected patient populations. | By inhibiting epichaperome function and breaking this mechanism, we believe PU-H71 can increase anti-cancer activity of JAK2 inhibitors. I look forward to seeing how the combination of these therapies can affect outcomes in patients for whom this resistance is associated with poor prognoses." The multicenter Phase 1b study is designed to assess the safety, tolerability, PK and preliminary efficacy of PU-H71 in subjects taking concomitant ruxolitinib. | HSP90 inhibition is lethal only when HSP90 is hyperconnected with the HSP70 machinery and other chaperomes, just as poly(ADP-ribose) polymerase (PARP) inhibition is lethal when breast or ovarian cancer cells harbour BRCA1 or BRCA2 mutations 115 . Therefore, we suggest that HSP90, per se, is not a target in cancer, in the sense that tumours become addicted to HSP90 only when HSP90 becomes integrated into epichaperome networks, potentially explaining the poor performance of HSP90 inhibitors in non-selected patient populations. By analysing 95 cancer cell lines, 40 primary AMLs and 23 primary breast tumours ex vivo and 51 solid tumours and lymphomas in patients, we found that 50-60% express variable epichaperome levels but only ~10% are high expressors, as defined by the amount of HSP90 residing in hyperconnected chaperome networks 35 . | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34294149057&p=1pl&v=1&x=pzihluZRVcZJ0XNPGmH0Mw |
10.1073/pnas.1511220112 | Biology_easy_338 | This positioning is consistent with evidence for increasingly sophisticated tool use in Australopithecus. | The first axis (PC1) is associated with the angle of the scapular spine and glenoid relative to the vertebral border of the blade, which is near perpendicular in MAA proxies and Pongo but has a more cranial orientation in African apes and hylobatids. | The shoulder of Australopithecus afarensis was more like an African ape than a human, and Australopithecus sediba closer to human's than to an ape's. This positioning is consistent with evidence for increasingly sophisticated tool use in Australopithecus. "The mix of ape and human features observed in Australopithecus afarensis' shoulder support the notion that, while bipedal, the species engaged in tree climbing and wielded stone tools. | 2 A-D and Fig. The first axis (PC1) is associated with the angle of the scapular spine and glenoid relative to the vertebral border of the blade, which is near perpendicular in MAA proxies and Pongo but has a more cranial orientation in African apes and hylobatids. More perpendicular spines tend to be longer and the blade wider, accounting for almost all of their covariation (Fig. | [1] | Biology | train | 1 | news | http://www.sci-news.com/othersciences/anthropology/science-homo-pan-last-common-ancestor-03220.html |
10.1007/s10336-017-1477-0 | Biology_easy_339 | The spotted birds certainly don't live in their original location any more, but it's possible they have migrated to another area due to deforestation. | The ND2 sequences obtained from Icterine and White-throated Greenbuls were nearidentical to database sequences obtained by other groups for these species and gave predicted translations yielding full-length ND2 homologous to the mitochondrial protein Fig. | But despite the thorough genetic analysis and unlikely alternative explanations, we can't yet say that the elusive birds absolutely, definitely don't exist - it looks like once something becomes a species, unspecying it is a tougher ask. "Formal resolution of the status of the Liberian greenbul will not be possible until either a population of [them] is rediscovered or alternatively shown not to exist," the team writes in the study. The spotted birds certainly don't live in their original location any more, but it's possible they have migrated to another area due to deforestation. | 'Universal' primers (described in ''Methods'') yielded fulllength ND2 from multiple samples of Icterine Greenbul and White-throated Greenbul, but gave no product from Liberian Greenbul DNA. The ND2 sequences obtained from Icterine and White-throated Greenbuls were nearidentical to database sequences obtained by other groups for these species and gave predicted translations yielding full-length ND2 homologous to the mitochondrial protein Fig. Bootstrap support (100 replicates) for key nodes is indicated. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34855042070&p=1pl&v=1&x=Aj2yuZYjg1DHHMgjyQ7rYg |
10.1007/s00244-015-0196-x | Biology_easy_340 | The bats had presumably died of white-nose syndrome, although genetic tests for the fungus were not performed. | Infusion of prostaglandin PGE 2 into the brains of hibernating golden-mantled ground squirrels (Spermophilus lateralis) caused periodic arousals along with increased body temperature . | The bats had presumably died of white-nose syndrome, although genetic tests for the fungus were not performed. Numerous chemicals were detected in the bat tissues. The PBDE flame retardants were detected in every sample tested. | In Asian chipmunks (Tamias asiaticus), prostaglandin PGD 2 increased in the brain to a maximum in February and declined by April suggesting a correlation between PGD 2 and hibernation . Infusion of prostaglandin PGE 2 into the brains of hibernating golden-mantled ground squirrels (Spermophilus lateralis) caused periodic arousals along with increased body temperature . These studies suggest that prostaglandin levels are related to hibernation in at least these three mammalian species. | [1] | Biology | train | 1 | news | http://earthsky.org/earth/bats-also-face-chemical-threats |
10.1038/s41467-018-06824-8 | Biology_easy_341 | The new discovery puts scientists one step closer toward demonstrating a common evolutionary basis for social behavior. | Improved L. albipes genome assembly and annotation. | The new discovery puts scientists one step closer toward demonstrating a common evolutionary basis for social behavior. "Finding this gene is a real watershed for the field." Females in cooler parts of France didn't generally have helpers, whereas those in warmer parts did--there, female bees would lay two sets of eggs, and hatchlings from the first set would tend to the second set of eggs. | Thus, our results are consistent with previous work suggesting that changes in gene regulation play key roles in the evolution of social behavior and that genes known to be associated with social behavior in L. albipes, such as syx1a, may also shape social behavior in other, distantly-related species. Improved L. albipes genome assembly and annotation. The draft L. albipes genome assembly consisted of 41,433 scaffolds with an N50 of~616 kb, a total assembly size of 341 Mb, and an estimated total size of 416 Mb . | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=37425745606&p=1pl&v=1&x=BF9poLDtNwHfjOufQy7mMA |
10.1126/science.1256773 | Biology_easy_342 | "To really prove that we reconstituted the cytokinesis signal, we needed to add the bilayer membrane and then see if it could recruit the proteins that would be on the cortex of the cell," Field said about the specialized layer beneath the cell membrane. | Kif4A depletion blocked CPC movement, and addback of recombinant Kif4A rescued it (Fig. | "We believe our work is a step forward, not only for understanding the assembly of the cleavage furrow but also, more generally, for understanding the biophysics of cytokinesis signaling." "To really prove that we reconstituted the cytokinesis signal, we needed to add the bilayer membrane and then see if it could recruit the proteins that would be on the cortex of the cell," Field said about the specialized layer beneath the cell membrane. The scientists saw this signal in part because Field chose to include actin in their system, a cellular component that is often discarded because it makes it so difficult to do experiments with the egg extract. | The maximal transport rate was close to that of Kif4A in an isolated aster that was not part of an AAIZ (Fig. Kif4A depletion blocked CPC movement, and addback of recombinant Kif4A rescued it (Fig. Live imaging showed partial colocalization of CPC and Kif4A movement ( fig. | [1] | Biology | train | 1 | news | http://www.science20.com/news_articles/cytokinesis_lite_cellular_division_now_with_no_cells-148202 |
10.1098/rsif.2012.0838 | Biology_easy_343 | As the challenge increases, however, the amphibian engages in a sprawling dance. | By reconstructing the angle of the resultant force vectors from the three force components (x, y and z), we were able to plot a graph of force magnitude F against angle a with respect to the substrate ( figure 5 ). | As the challenge increases, however, the amphibian engages in a sprawling dance. The researchers found that this splaying behavior is rooted in the same physical principle that applies to adhesive tape. The easiest way to peel tape away from a surface is by pulling one corner away at the largest possible angle from the sticking surface; pulling the tape at a shallow angle makes it virtually impossible to get unstuck. | However, as the latter study investigated adhesion on rough surfaces, the locusts were splaying out their legs to reduce the approach angle of the claws when interlocking with surface asperities. By reconstructing the angle of the resultant force vectors from the three force components (x, y and z), we were able to plot a graph of force magnitude F against angle a with respect to the substrate ( figure 5 ). The latter is correlated with the surface energy of the newly created surface during crack propagation, but for most tapes the fracture energy is strongly dominated by viscous dissipation. | [1] | Biology | train | 1 | news | http://www.scientificamerican.com/article.cfm?id=frogs-cling-to-and-peel-from-surfaces-just-like-adhesive-tape |
10.1111/gcb.13876 | Biology_easy_344 | Furthermore, forests and land offer the most cost-effective way to store more carbon right now. | Accounting for these delayed emissions, the net sink for carbon (declining emissions and declining rates of forest re-growth) was greatest immediately after harvests ceased and declined as regrowing forests aged. | In 2017, the world lost 39 million acres (nearly 16 million hectares) of tropical forests -- an area equivalent in size to Bangladesh -- at a near-record rate of 40 football fields every minute for the entire year, according to Global Forest Watch. Furthermore, forests and land offer the most cost-effective way to store more carbon right now. We need to significantly elevate investment in these solutions. | Putting the tropical and temperate zone and boreal forests together, yielded a global gross sink (2006) (2007) (2008) (2009) (2010) (2011) (2012) (2013) (2014) (2015) of 4.4 PgC/year (Table 3) . Accounting for these delayed emissions, the net sink for carbon (declining emissions and declining rates of forest re-growth) was greatest immediately after harvests ceased and declined as regrowing forests aged. The net global carbon sink obtainable if deforestation and harvests were stopped would be À34 PgC by 2100 (15 + 19). | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34958843662&p=1pl&v=1&x=ADGn1_xewWPJ_1OZt5xdOA |
10.1098/rsos.171474 | Biology_easy_345 | Conservatives pushed back hard against the report, which also concluded that veterans coming home from war could be susceptible to recruitment efforts. | Broadly speaking, findings from our study provided evidence that this was not the case. | "When you dehumanize your opponents, whether Democrats, the news, immigrants, people of faith, of different faiths, you're running the risk of someone taking your words and acting upon it." Conservatives pushed back hard against the report, which also concluded that veterans coming home from war could be susceptible to recruitment efforts. Johnson said that with Trump in office the recruitment, prevalence of the groups and hate crimes have spiked. | Given this popularity, one might argue that a small effect linking violent gaming to aggressive behaviour would have consequences for society as a whole . Broadly speaking, findings from our study provided evidence that this was not the case. Said differently, the results derived from our hypothesis testing did not support the position that violent gaming relates to aggressive behaviour. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=39881272230&p=1pl&v=1&x=agjUuQHKttCmyqc0lNUvPA |
10.1016/j.cell.2018.04.034 | Biology_easy_346 | They identified CDK12 mutations in 25/360 mCRPC patients (6.9%), but in only 6/498 patients with primary prostate cancer. | Indeed, we observed an exceptional response (PSA decline) with anti-PD1 monotherapy in two out of four mCRPC patients in this study ( Figure 7A ). | This is an exciting prospect for patients who have CDK12 alterations and may benefit from immunotherapy." They identified CDK12 mutations in 25/360 mCRPC patients (6.9%), but in only 6/498 patients with primary prostate cancer. "All patients showed biallelic inactivation of CDK12," they note, while "strikingly," the CDK12 mutations were mutually exclusive to all of the already known primary genetic drivers (PGDs) analysed, including ETS fusions, SPOP mutations, HRD (homologous recombination-deficiency, ATM mutations and mismatch repair-deficiency (MMRD)." | Taken together, our data suggest that CDK12 mutant prostate cancer is intrinsically immunogenic , and CDK12 mutations may identify a subset of patients where immunotherapy would be efficacious. Indeed, we observed an exceptional response (PSA decline) with anti-PD1 monotherapy in two out of four mCRPC patients in this study ( Figure 7A ). Furthermore, identification of CDK12 mutation-associated neoantigens may help in the design of personalized tumor vaccines. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34304544254&p=1pl&v=1&x=4ldt3u_6ItGR2RE2UuBujA |
10.1016/j.cell.2013.08.004 | Biology_easy_348 | The researchers' identification of the role SIK1 plays in the body clock offers a tractable target for drugs that could help travelers adjust faster to changes in time zone and help ameliorate the effects of rotational shift work. | An entrainment stimulus causes CRTC1 to coactivate CREB, inducing the expression of Per1 and Sik1. | Kevin Flanagan
"Having such a hand-brake on the circadian clock systems makes sense so as to prevent excessive responses to environmental change, and that it is only in our modern 24-hour society, with Thomas Edison's light bulbs, Nikola Tesla's electricity and jet airplanes, that we begin to realize our biological limitations," Duffield said. The researchers' identification of the role SIK1 plays in the body clock offers a tractable target for drugs that could help travelers adjust faster to changes in time zone and help ameliorate the effects of rotational shift work. "Being involved in this project as an undergraduate student and presenting my data at an international conference really crystalized my interest in scientific research as a career," Flanagan said. | An entrainment stimulus causes CRTC1 to coactivate CREB, inducing the expression of Per1 and Sik1. SIK1 then inhibits further shifts of the clock by phosphorylation and deactivation of CRTC1. Knockdown of Sik1 within the SCN results in increased behavioral phase shifts and rapid re-entrainment following experimental jet lag. | [1] | Biology | train | 1 | news | http://www.healthcanal.com/disorders-conditions/sleep/42436-researchers-identify-new-drug-target-for-treating-jet-lag-and-shift-work-disorders.html |
10.1038/s41467-018-06108-1 | Biology_easy_349 | Advantageous genetic mutations in addition to spare copies
Due to the large amount of genetic information, A. kamchatica is better equipped to adapt to new environmental conditions. | 1 in Akama et al. | With 450 million base pairs, its genome is somewhat small for a polyploid plant, but still very complex. Advantageous genetic mutations in addition to spare copies
Due to the large amount of genetic information, A. kamchatica is better equipped to adapt to new environmental conditions. "With these results, we have demonstrated on a molecular-genetic level that genome duplications can positively affect the adaptability of organisms," says plant scientist Timothy Paape. | A further step will be to incorporate polymorphism, gene expression, and species distribution data (i.e., landscape genomics) of diploid parents and allopolyploid hybrids to identify the contributions of parental adaptations for broadening climatic regimes and abiotic habitats in polyploids. 1 in Akama et al. Here, the common reads are the reads that aligned equally well to both parental genomes. | [1] | Biology | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/iSCNAuficZY/ |
10.1098/rsos.171474 | Biology_easy_350 | Further, Prince Harry said these games create an addiction that keeps a player hooked to their computer screen for as long as possible. | There was no evidence for a critical tipping point relating violent game engagement to aggressive behaviour. | The authorities received a total of 34 letters, including eight from parents, requesting a ban on the game due to its addictive nature. Further, Prince Harry said these games create an addiction that keeps a player hooked to their computer screen for as long as possible. It's like waiting for the damage to be done and kids turning up on your doorsteps and families being broken down," Prince Harry said. | Results did not support this prediction, nor did they support the idea that the relationship between these factors follows a nonlinear parabolic function. There was no evidence for a critical tipping point relating violent game engagement to aggressive behaviour. Sensitivity and exploratory analyses indicated these null effects extended across multiple operationalizations of violent game engagement and when the focus was on another behavioural outcome, namely, prosocial behaviour. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=39008420426&p=1pl&v=1&x=Y9M61MqnjfzY0SC9noiwvw |
10.1038/s41467-018-04151-6 | Biology_easy_351 | "An example of perfect adaptation is our sense of smell," she said. | Indeed, it raises the question as to whether all biochemical networks, of any size, with a fundamental need to exhibit robust functionalities, are characterized by modular architectures involving just a small number of topological basis modules. | "My research is giving us a new way to look at unravelling network complexity in nature." "An example of perfect adaptation is our sense of smell," she said. "Our sense of smell has exhibited perfect adaptation. | This deep connection between compensation and modularity suggests that a modular design may characterize a wider class of robust networks beyond RPA-capable networks. Indeed, it raises the question as to whether all biochemical networks, of any size, with a fundamental need to exhibit robust functionalities, are characterized by modular architectures involving just a small number of topological basis modules. Several lines of evidence already support the generalization of our network modularization to other bio-signaling contexts. | [1] | Biology | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/BUs3tnStd9A/ |
10.3945/jn.113.188441 | Biology_easy_352 | Ahora que sabes que la sopa instantanea puede provocar infartos y derrame cerebral, es mejor que no la consumas tan seguido. | It is interesting to see that there was a simultaneous increase in both healthy metabolic components (HDL cholesterol increase, TG decrease) and some unhealthy metabolic components (abdominal obesity, LDL cholesterol increase) with the MP. | Es decir, comprar la pasta, que venden por separado, y agregar los ingredientes naturales de tu preferencia, asi la sopa no tendra tantos conservadores daninos para tu salud. Ahora que sabes que la sopa instantanea puede provocar infartos y derrame cerebral, es mejor que no la consumas tan seguido. Mas noticias en MSN:
Los 50 peores alimentos para tu corazon (Eat This, Not That!) | The TP, rich in fruit, vegetables, and fish, was inversely associated with abdominal obesity and elevated blood pressure, which is in agreement with previous studies . It is interesting to see that there was a simultaneous increase in both healthy metabolic components (HDL cholesterol increase, TG decrease) and some unhealthy metabolic components (abdominal obesity, LDL cholesterol increase) with the MP. The direct association with increased HDL cholesterol and a decrease in TGs with the MP might be mediated by a reduced intake of carbohydrates , such as polished rice , and an increased intake of fat among those in the highest quintile of the MP; there were similar findings in a Japanese population . | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=39561372381&p=1pl&v=1&x=lNU4nCAJSUXMnFz01j2kDA |
10.1126/sciadv.aau2642 | Biology_easy_355 | To lower the risk of extinction, tougher hunting regulations are needed to ensure that the ortolan can make it out of France without ending up on the secret menu of a gourmet restaurant. | An increase in survival representing an additional 30,000 postbreeding live birds (i.e., a reduction of approximately four points of the mortality percentage) would induce a 23% decrease in the 100-year extinction probability, while this decrease would reach 50 to 85% in the most favorable scenarios of reproductive output, mimicking conditions that occurred in northern Europe before the attested large-scale decline of farmland birds . | These northern populations, the study's authors write, are "directly threatened with extinction and [can]not persist without marked increases in survivorship." As Parletta notes, the key to these northern ortolans' long-term survival is relatively simple. To lower the risk of extinction, tougher hunting regulations are needed to ensure that the ortolan can make it out of France without ending up on the secret menu of a gourmet restaurant. | S5 ), mild to moderate reductions in mortality probability lead to strong changes in extinction risk and improvements in conservation status. An increase in survival representing an additional 30,000 postbreeding live birds (i.e., a reduction of approximately four points of the mortality percentage) would induce a 23% decrease in the 100-year extinction probability, while this decrease would reach 50 to 85% in the most favorable scenarios of reproductive output, mimicking conditions that occurred in northern Europe before the attested large-scale decline of farmland birds . In these favorable scenarios, a moderate reduction of mortality (five points) is sufficient to improve the Red List conservation status of the population from Endangered to "Least Concern." | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=39297041118&p=1pl&v=1&x=HPmZkhwNaH9VtCuV7KmVkg |
10.1016/j.cell.2016.04.014 | Biology_easy_356 | The study is available online in Cell. | When analyses focused on innate versus adaptive lineages, enhancers with augmented H3K27ac levels in Th cells were enriched for motifs bound by BATF/AP1, IRF, NFAT, and EGR ( Figure 3A See also Figure S2 and Tables S1, S2, and S3. | Surprisingly, the regions of DNA that make up these master switches include numerous genetic variants linked to a range of autoimmune diseases, the researchers found. The study is available online in Cell. "In some cases, individual variations in a person's DNA probably tweak the settings of these switches upward, leading to overactivation of the immune cells and autoimmune disease." | Many lineage decisions or biological responses are dominated by a single TF or related family. When analyses focused on innate versus adaptive lineages, enhancers with augmented H3K27ac levels in Th cells were enriched for motifs bound by BATF/AP1, IRF, NFAT, and EGR ( Figure 3A See also Figure S2 and Tables S1, S2, and S3. Consistent with this finding, RUNX3 is essential for ILC development in mouse . | [1] | Biology | train | 1 | news | http://healthmedicinet.com/news/scientists-discover-master-dimmer-switches-that-control-activity-of-immune-cells/ |
10.1038/s41467-019-09863-x | Biology_easy_357 | Other factors also have the potential to affect the pace of future climate change. | The corrections φ ω , φ τ , φ p (all non-negative) ensure quasi-independence of the (ω,τ, p) m,s set as a whole from the scenarios or climate models used. | But they're not the only ones that interest scientists. Other factors also have the potential to affect the pace of future climate change. If Greenland or Antarctica were to eventually reach a point of complete collapse, their effects on global sea levels would be catastrophic. | Each combination of a GCM (m) and climate scenario (s), either in SiBCASA or JULES simulations, produces its own set of optimal equilibrium carbon, lag and power parameters (ω,τ, p) m,s that achieves the best emulator fit. The corrections φ ω , φ τ , φ p (all non-negative) ensure quasi-independence of the (ω,τ, p) m,s set as a whole from the scenarios or climate models used. The latter allows us to use these sets of values to construct the corresponding probability distributions for ω,τ, p in PAGE-ICE, which are expected to work throughout the simulated range of temperatures. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=39068075992&p=1pl&v=1&x=s9tSrEITwL3rwfEi9cWT-w |
10.1098/rsif.2012.0838 | Biology_easy_358 | "This experiment shows the maximum adhesive force a frog can take," says Thomas Endlein, a biologist at the University of Glasgow, UK, who led the study. | Maintaining a shallow angle of the pulling force vector to the substrate can be achieved by adopting a sprawled posture, placing the adhesive pads as far away from the body as possible. | The easiest way to peel tape away from a surface is by pulling one corner away at the largest possible angle from the sticking surface; pulling the tape at a shallow angle makes it virtually impossible to get unstuck. "This experiment shows the maximum adhesive force a frog can take," says Thomas Endlein, a biologist at the University of Glasgow, UK, who led the study. "But usually frogs would avoid overhanging surfaces to avoid such difficult sprawling positions." | by increasing the angle of the leg to the substrate) would facilitate detachment by allowing peeling. Maintaining a shallow angle of the pulling force vector to the substrate can be achieved by adopting a sprawled posture, placing the adhesive pads as far away from the body as possible. These large inward forces help to ensure that the angle of the pulling force vector towards the substrate remains small. | [1] | Biology | train | 1 | news | http://www.scientificamerican.com/article.cfm?id=frogs-cling-to-and-peel-from-surfaces-just-like-adhesive-tape |
10.1111/gcb.13276 | Biology_easy_359 | "We want this index to be used to predict how corals might react to future bleaching events. | 5 -regression continues to decrease for higher taxa below 0.02, but is no longer significant). | "Using very large data sets, we have teased out valuable information that will help researchers identify global trends and learn about individual corals," says coauthor Vadim Backman, professor of biomedical engineering. "We want this index to be used to predict how corals might react to future bleaching events. The index will be available online, so that data on corals can be added as they become available, making the tool even more robust. | Maximal R 2 (0.33) was observed for sites with two taxa, and it monotonically decreased to 0.057 as the number of taxa per site increased to 44 (P < 0.01, Fig. 5 -regression continues to decrease for higher taxa below 0.02, but is no longer significant). Therefore, the effect of extrinsic factors on BRI j is negligibly small, P ext < 6%. | [1] | Biology | train | 1 | news | http://www.futurity.org/coral-reefs-climate-change-1138362/ |
10.1186/s40168-015-0071-z | Biology_easy_360 | "This work significantly advances our efforts to decipher how human milk amazingly orchestrates colonization of the infant gut by helpful bacteria, which then protects and guides intestinal development in the early stages of life. | In non-secretors, the average amount of sialylation was 23.4% ± 5.7%, which is significantly higher than the amounts of sialylation found in secretors, which averaged 18.2% ± 4.8% (p < 0.0001). | The researchers said that understanding the mechanism behind the observed secretor/non-secretor differences may prove critical to compensating for it in situations where the infants are vulnerable, such as by providing carefully chosen pre- or probiotics. "This work significantly advances our efforts to decipher how human milk amazingly orchestrates colonization of the infant gut by helpful bacteria, which then protects and guides intestinal development in the early stages of life. Understanding this incredible sequence of events will provide examples for how to repair this process where it has been disrupted, such as in premature infants or colicky babies," Mills said. | Although the total oligosaccharide abundance and the relative amount of total (including 2′ and 3′) fucosylation were comparable among averaged data from the two phenotypes, the relative abundances of non-fucosylated neutral and sialylated structures differed. In non-secretors, the average amount of sialylation was 23.4% ± 5.7%, which is significantly higher than the amounts of sialylation found in secretors, which averaged 18.2% ± 4.8% (p < 0.0001). Conversely, non-secretor milk had lower relative amounts of non-fucosylated neutral structures than secretor milk, with 21.3% ± 8.8% and 25.4% ± 7.3%, respectively (p = 0.023). | [1] | Biology | train | 1 | news | http://www.sciencedaily.com/releases/2015/04/150409143035.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1093/pcp/pct167 | Biology_easy_361 | "Isolating the genes that determine susceptibility could lead to developing immunities for different varietals and other crop plants and may contribute to general scientific knowledge of the grapevine, which has not been studied to the extent of other plants." | 4) . | Gassmann says this research will open the door for discussing techniques to breed more resistant grapevines in the future. "The grapevine could be bred to prevent susceptibility and to keep the character of the wine intact," Gassmann said. "Isolating the genes that determine susceptibility could lead to developing immunities for different varietals and other crop plants and may contribute to general scientific knowledge of the grapevine, which has not been studied to the extent of other plants." | Average currents in VvNPF3.2-injected oocytes at pH 5.0 were not significantly different from the control when 10 mM amino acids (P > 0.05) or dipeptides (P > 0.1-0.4) were applied (Fig. 4) . However, 10 mM HNO 3 incited currents in these batches of oocytes that were highly significantly different from uninjected control oocytes (P < 0.0001), indicating that VvNPF3.2 selectively transports nitrate. | [1] | Biology | train | 1 | news | http://www.sciencedaily.com/releases/2014/04/140430133139.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1016/j.cell.2013.08.004 | Biology_easy_362 | "It would appear that SIK1 plays a common role in our circadian clocks found throughout our body, and works as a hand-brake on our ability to shift our biorhythms and adjust to new time zones, whether these are real or artificial, such as those produced during shift work schedules." | The same regulatory processes that induce Per1 also induce Sik1. | We also showed this effect in both peripheral tissues as well as in the clock in the brain. "It would appear that SIK1 plays a common role in our circadian clocks found throughout our body, and works as a hand-brake on our ability to shift our biorhythms and adjust to new time zones, whether these are real or artificial, such as those produced during shift work schedules." Kevin Flanagan
"Having such a hand-brake on the circadian clock systems makes sense so as to prevent excessive responses to environmental change, and that it is only in our modern 24-hour society, with Thomas Edison's light bulbs, Nikola Tesla's electricity and jet airplanes, that we begin to realize our biological limitations," Duffield said. | An appreciation of the role of CRTC1-SIK1 regulation in these noncircadian pathways very much supports our interpretation of how this signaling pathway functions within the molecular clock. The same regulatory processes that induce Per1 also induce Sik1. In contrast to these kinases, SIK1 does not target the core clock proteins to control their degradation; rather, it attenuates the induction of clock genes in response to entraining stimuli, functioning as a negative-feedback mechanism to deactivate the molecular pathways that are activated following a phase-shifting stimulus. | [1] | Biology | train | 1 | news | http://www.healthcanal.com/disorders-conditions/sleep/42436-researchers-identify-new-drug-target-for-treating-jet-lag-and-shift-work-disorders.html |
10.1534/genetics.116.197285 | Biology_easy_364 | / no comments
LAWRENCE -- Rest easy, folks. | Lower cleavage rates only slightly decrease establishment probabilities (Fig. | / no comments
LAWRENCE -- Rest easy, folks. So natural selection favors individuals lacking modified genes and purges a given genetic alteration within a population within a few generations. "By doing that they spread through a population much more quickly." | However, this effect becomes significant only when resistance costs are codominant, not when they are recessive (SI Fig. Lower cleavage rates only slightly decrease establishment probabilities (Fig. This is because for a slower driver it will take longer until resistance alleles from the SGV experience their fitness advantage, increasing their chances of being lost to drift and/or selection in the meantime. | [1] | Biology | train | 1 | news | http://healthmedicinet.com/news/research-shows-nature-can-beat-back-scientific-tinkering-with-genes-of-entire-species/ |
10.1126/sciadv.aau1291 | Biology_easy_366 | The device has only been tested on mice so far, but the results look promising. | As shown in Fig. | The device has only been tested on mice so far, but the results look promising. It regulates brain activity much like a pacemaker regulates heart rhythm by sending its own signals regardless of what the rest of the brain might be doing. The implant is not without risks, since it requires invasive, risky brain surgery. | This illustrates the importance of choosing the appropriate drug of interest and effectively rules out the small current stimulus (average, <35 nA) associated with the FIP operation as the primary therapeutic mechanism. As shown in Fig. 4 , in the absence of additional GABA delivery, the second 4AP injection induced a series of intense SLEs. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34950349292&p=1pl&v=1&x=ffMz4n5n4XLtDMruPZnsFg |
10.1016/j.cell.2016.09.056 | Biology_easy_367 | The wager paid off, and the researchers got their first full look at a tetraspanin--including some unique and unexpected features. | Our molecular dynamics simulations suggest that CD81 may exist in both closed and open conformations and that the equilibrium between closed and open conformations may be shifted toward the closed state when cholesterol is bound. | Others shrugged, figuring the transmembrane portion wasn't important but merely served as an anchor for the outer segment. The wager paid off, and the researchers got their first full look at a tetraspanin--including some unique and unexpected features. "Brandon's perseverance and biochemical skills and Andrew's determination and deep knowledge of membrane protein structural biology made it possible," said Blacklow. | Our results reveal that CD81 binds cholesterol and that E219 is an important residue in the binding pocket, offering a potential mechanism for how tetraspanins might detect cholesterol or other membrane lipids (whereas CD81 and tspan10 both possess a polar residue in this position, most other tetraspanins have a polar residue one helical turn earlier, with other cholesterol-interacting residues highly conserved throughout evolution). Our molecular dynamics simulations suggest that CD81 may exist in both closed and open conformations and that the equilibrium between closed and open conformations may be shifted toward the closed state when cholesterol is bound. Modulation of tetraspanin conformation in response to differences in cholesterol concentration could explain how tetraspanins regulate the subcellular localization of their partner proteins D117 K116 D117 K201 D196 TM3 TM3 TM4 TM4 EC2 EC2 EC2 EC2 TM1 TM2 TM3 TM4 F58 F126 6 6 6 6 6 6 6 6 6 6 6 6 6 E EC2 | [1] | Biology | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/Ay74vlkGcfw/ |
10.1186/s40168-015-0071-z | Biology_easy_370 | And they were right. | Conversely, non-secretor milk had lower relative amounts of non-fucosylated neutral structures than secretor milk, with 21.3% ± 8.8% and 25.4% ± 7.3%, respectively (p = 0.023). | So those women make much less of the special sugar. And they were right. The study only included 44 women, but it was still telling. | In non-secretors, the average amount of sialylation was 23.4% ± 5.7%, which is significantly higher than the amounts of sialylation found in secretors, which averaged 18.2% ± 4.8% (p < 0.0001). Conversely, non-secretor milk had lower relative amounts of non-fucosylated neutral structures than secretor milk, with 21.3% ± 8.8% and 25.4% ± 7.3%, respectively (p = 0.023). No obvious differences between secretor and non-secretor groups were found (Tables 2 and 3 ). | [1] | Biology | train | 1 | news | http://medcitynews.com/2015/04/one-gene-mother-can-affect-bacteria-babys-gut/ |
10.1038/s41467-018-05229-x | Biology_easy_371 | This is due to the system's extremely high optical nonlinearity, which occurs when Wannier-Stark localization sets in. | In Fig. | Under the extreme conditions of the experiment, a bright red glow can be seen to emanate from the gallium arsenide crystal used as a semiconductor. This is due to the system's extremely high optical nonlinearity, which occurs when Wannier-Stark localization sets in. The system remains stable as long as the rubber band is as strong as the repulsion is. | Under these conditions, a clear temporal modulation of differential absorption manifests itself in horizontally oriented differential transmission patterns with twice the periodicity of the biasing transients that are visible in Fig. In Fig. For E < 100 kV/cm, Franz-Keldysh signatures similar to the ones found experimentally in Fig. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34670950732&p=1pl&v=1&x=x3oAuC5eU9X8uvPYQct7_A |
10.1038/s41467-019-09863-x | Biology_easy_372 | Sto metaxu, khores opos e Norbegia, o Kanadas kai e Souedia einai 25-34% pio plousies ap' o,ti tha etan khoris tis pio megales pagkosmies thermokrasies. | The SAF emulator models the global SAF as a function of the GMST (Methods), reproducing the nearly monotonic decline driven largely by the Arctic sea ice and land snow components. | Eno e omada tou Yumashev kataskeuase tis mellontikes sunthekes tes klimatikes allages, mia melete pou demosieuteke prosphata sto Proceedings of the National Academy of Sciences ektima ten pagkosmia oikonomike zemia pou ekhei ede proklethei. Sto metaxu, khores opos e Norbegia, o Kanadas kai e Souedia einai 25-34% pio plousies ap' o,ti tha etan khoris tis pio megales pagkosmies thermokrasies. E omada upologise auta ta noumera exetazontas makrokhronia thermokrasia kai metreseis AEP se 165 khores, gia na doun an uperkhe skhese anamesa sten oikonomike anaptuxe kai tis diakumanseis tes thermokrasias. | In contrast, the SAF for the rest of the world stays nearly constant until high GMST anomalies. The SAF emulator models the global SAF as a function of the GMST (Methods), reproducing the nearly monotonic decline driven largely by the Arctic sea ice and land snow components. 2 ), which is implicitly included in the 2 × CO 2 ECS parameter (Methods), the SAF emulator accounts for the difference between the nonlinear SAF and its constant legacy value. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=39093010673&p=1pl&v=1&x=sZM4NVw7ruP2hKMrRk-2DA |
10.1098/rsos.180695 | Biology_easy_377 | "We'll become less capable of coping with climate change." | Based purely on its indoor temperature and humidity, you would be unlikely to discern whether a house from our dataset was in Wyoming or Mississippi. | We could also be adapting to the cozy indoor climates where we spend most of our time, speculates Gilligan. And while the inside of a house may be similar to an African savannah, the house will probably stay more constant than any real outdoor climate. "We'll become less capable of coping with climate change." | They do so to such an extent that indoor climate is no longer well correlated to outdoor climate (table 1) . Based purely on its indoor temperature and humidity, you would be unlikely to discern whether a house from our dataset was in Wyoming or Mississippi. Of the two climatic variables, we considered, indoor humidity was more strongly correlated with outdoor conditions than was the case for temperature, but this correlation was weak. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=38798635240&p=1pl&v=1&x=dKEYUvmyKXnUNRgeE2st1A |
10.1038/s41590-018-0068-4 | Biology_easy_378 | These results suggest that TLR8 acts as a key switch for protective immune responses. | (Fig. | Moreover, the scientists also found that patients carrying an activating TLR8 gene variant responded better to a live vaccine against tuberculosis, which resulted in improved protection against disease. These results suggest that TLR8 acts as a key switch for protective immune responses. "These results may enable us to develop new vaccines that will combine the safety of modern subunit vaccines with the high efficacy of live vaccines." | Recognition of bacterial viability is conserved in porcine APCs. (Fig. Secretion of IL-6 was induced similarly by live and dead EC and ST (Fig. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=33723683656&p=1pl&v=1&x=R9OQAdHcxos4adubuX4cGg |
10.1038/s41467-019-09863-x | Biology_easy_379 | <<Ta euremata mas sterizoun ten anagke gia pio energa metra periorismou gia na parameinei e auxese tes pagkosmias thermokrasias kato apo 2 bathmous Kelsiou>>, delose o Yumashev. | Such assessments could provide a more complete understanding of the socio-economic risks from climate change that in turn can help guide policymakers towards prudent decisions on emissions reduction targets. | VICE Video: Oi Ellenes pou Pisteuoun oti e Ge Einai Epipede
Parakoloutheste ola ta binteo tou VICE, meso tes neas selidas VICE Video Greece sto Facebook. <<Ta euremata mas sterizoun ten anagke gia pio energa metra periorismou gia na parameinei e auxese tes pagkosmias thermokrasias kato apo 2 bathmous Kelsiou>>, delose o Yumashev. Tetoia metra perilambanoun ten ektetamene epharmoge ananeosimon energeion opos e eliake energeia. | The methodology introduced in this paper could be used to quantitatively assess the economic and climate policy implications of the other tipping elements in the Earth's climate system, including the Greenland and West Antarctic ice sheets, Amazon rainforest, boreal forest, Sahel and ENSO 13 . Such assessments could provide a more complete understanding of the socio-economic risks from climate change that in turn can help guide policymakers towards prudent decisions on emissions reduction targets. The imaginary Zero Emissions scenario in which all global emissions stop in the base year 2020 characterises the effect of the historic emissions on the PCF and SAF. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=39093010673&p=1pl&v=1&x=sZM4NVw7ruP2hKMrRk-2DA |
10.1016/j.neuron.2014.05.028 | Biology_easy_382 | The finding may accelerate the development of treatments for preventing PTSD (post-traumatic stress disorder). | Using double fluorescent in situ hybridization (FISH), we show that Tac2 gene expression is mostly not colocalized with PKCd or Enk and is expressed primarily within the CeM (Figures 2A-2F ). | Potential drug target for PTSD prevention
The dark smudge on the left side shows that the gene Tac2 is robustly activated after fear learning in the central amygdala. The finding may accelerate the development of treatments for preventing PTSD (post-traumatic stress disorder). "PTSD is unique among psychiatric disorders in that we know when it starts - at the time of the trauma. | Of note, Enk mRNA levels are increased after FC in the CeL (Petrovich et al., 2000) . Using double fluorescent in situ hybridization (FISH), we show that Tac2 gene expression is mostly not colocalized with PKCd or Enk and is expressed primarily within the CeM (Figures 2A-2F ). Thus, given the lack of colocalization and regional and functional specificity of these cell populations, we have uncovered a subdivision-specific cell population that may be involved in the consolidation of fear memory. | [1] | Biology | train | 1 | news | http://www.healthcanal.com/mental-health-behavior/52580-potential-drug-target-for-ptsd-prevention.html |
10.1038/s41467-018-08038-4 | Biology_easy_383 | "This could fundamentally improve our understanding of how these small biological systems function. | All-in-all, these results show that, at this acoustic frequency, the noise equivalent pressure of the sensor is within 9% of the noise floor introduced by thermal collisions of gas molecules with the sensing element. | "We'll soon have the ability to listen to the sound emitted by living bacteria and cells," she said. "This could fundamentally improve our understanding of how these small biological systems function. "A deeper understanding of these biological systems may lead to new treatments, so we're looking forward to seeing what future applications emerge." | The gas damping noise power therefore dominates by a factor of γ gas / γ~7.4. All-in-all, these results show that, at this acoustic frequency, the noise equivalent pressure of the sensor is within 9% of the noise floor introduced by thermal collisions of gas molecules with the sensing element. This gas damping noise floor is fundamental, in that it cannot be eliminated without removing the gas through which the acoustic wave itself propagates. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=38265192014&p=1pl&v=1&x=jM9LqTh2dU9LfWHNQwm_FQ |
10.1534/genetics.116.197285 | Biology_easy_386 | The KU researcher said by tying the mutation for shorter lifespan, or resistance to dengue fever in mosquitoes, for example, to one of these selfish genetic elements that can drive through populations, scientists found a way to overcome fitness cost. | We also limited our study to resistance at the target site, even though trans resistance might be common. | "By doing that they spread through a population much more quickly." The KU researcher said by tying the mutation for shorter lifespan, or resistance to dengue fever in mosquitoes, for example, to one of these selfish genetic elements that can drive through populations, scientists found a way to overcome fitness cost. "It's compensated for by the Mendelian cheating going on, so you can spread it through a population. | Furthermore, resistance alleles may be created if homology-directed repair inserts the driver construct, but introduces errors that prevent it from driving. We also limited our study to resistance at the target site, even though trans resistance might be common. CGD hosts may harbor natural variation for Cas9 expression levels or may produce peptides or RNA that silences the CRISPR machinery 30 . | [1] | Biology | train | 1 | news | http://healthmedicinet.com/news/research-shows-nature-can-beat-back-scientific-tinkering-with-genes-of-entire-species/ |
10.1086/693564 | Biology_easy_387 | The Virginia-based nonprofit group claimed the auction raised $182,500 for its conservation programs. | We make the simplifying assumption that mites on vertebrates are relatively well studied (given that thousands of species have already been described). | The Virginia-based nonprofit group claimed the auction raised $182,500 for its conservation programs. The most valuable animal turned out to be a wormlike amphibian from Panama, which drew a winning bid of $25,000 from a British sustainable building materials company called EnviroBuild. With more than 27,000 species at risk of extinction, auctioning off naming rights seems like a fairly harmless way to increase public awareness and raise much-needed funding for conservation efforts. | 1998; ; specifically these four studies respectively estimated ratios of beetle species to mite species of 4∶7, 38∶36, 51∶36, and 30∶33 for a mean ratio across studies of 1.13 or a combined ratio, based on species and not separate studies, of 123∶112 or 0.91). We make the simplifying assumption that mites on vertebrates are relatively well studied (given that thousands of species have already been described). Moreover, even if each bird and mammal species had an average of 30 unique mite species (almost certainly an overestimate; Walter and Proctor 2013), the impact on overall mite diversity would be limited relative to estimated mite diversity overall (e.g., 10,000 bird + 5000 mammal species × 30 mites per species = 450,000 mite species). | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=38981580573&p=1pl&v=1&x=Y8hj7JQLdrpGIg7lpFM9kg |
10.1111/1365-2656.12871 | Biology_easy_390 | "The effect of RHDV disease virus on rabbits is enhanced by previous infection with MYXV virus. | We believe that future research avenues should include investigating disease transmission dynamics at finer temporal scales to test the importance of heterogeneity in modes of RHDV transmissions and doses of infection on the mortality rates of rabbits susceptible to RHDV. | It is no longer a case of which disease is a better control agent, because their effectiveness is intrinsically linked." "The effect of RHDV disease virus on rabbits is enhanced by previous infection with MYXV virus. Survival rates were lowest for rabbits which survived MYXV infection and then were exposed to RHDV disease," says Dr Fordham from the University's Environment Institute. | This argument could partly explain recent on-ground observations of increased survival (i.e., less infection-induced mortality) and abundance of South Australian rabbit populations and in silico evidence of rabbits escaping infection in some years . We believe that future research avenues should include investigating disease transmission dynamics at finer temporal scales to test the importance of heterogeneity in modes of RHDV transmissions and doses of infection on the mortality rates of rabbits susceptible to RHDV. Our analysis was restricted by practical limits to relatively long time intervals (ca. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34506942217&p=1pl&v=1&x=OCP5j07SbNKK_Tx7JPH1Dw |
10.1038/s41467-018-04906-1 | Biology_easy_391 | Not only that, the technology could also potentially allow smartphone manufacturers to extend the fingerprint sensor's coverage on a larger portion of a smartphone display. | Both R s and T decrease as their area fraction increases, as shown in Supplementary Fig. | "Furthermore, this fingerprint sensor array can be integrated with all transparent forms of tactile pressure sensors and skin temperature sensors, to enable the detection of a finger pressing on the display." Not only that, the technology could also potentially allow smartphone manufacturers to extend the fingerprint sensor's coverage on a larger portion of a smartphone display. In theory, this means that user's won't have to worry about where they have to place their finger when they try to unlock their phones. | The area fraction of the AgNF and AgNW networks, which can be controlled by the electrospinning duration, determines R s and T of the transparent AgNF-AgNW hybrid electrode. Both R s and T decrease as their area fraction increases, as shown in Supplementary Fig. Figure 2c presents R s of the resulting AgNF-AgNW hybrid network as a function of its T in the visible light range (wavelength: 550 nm). | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34467889819&p=1pl&v=1&x=bwlU4e1aRXgMmGqDDaSdMA |
10.1098/rsos.171474 | Biology_easy_392 | The draft is currently awaiting revision by parliament's speaker. | Finally, in this study, we draw general inferences about gaming effects in a general way across the population as a whole. | "The committee is concerned about the obsession over these electronic games that ignite violence among children and youth. The draft is currently awaiting revision by parliament's speaker. In one incident in November, a youngster reportedly killed his friend with a shotgun in Erbil province while recreating a PUBG scene. | To this end, field or natural experiments using multi-wave random-intercepts cross-lagged panel modelling should follow the present work to provide an expanded test of the effects of violent gaming on human behaviour. Finally, in this study, we draw general inferences about gaming effects in a general way across the population as a whole. It might be the case that specific cohorts of people sharing background factors associated with technology use such as carer educational attainment or material deprivations are more or less likely to be influenced by their experiences with virtual environments . | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=39008420426&p=1pl&v=1&x=Y9M61MqnjfzY0SC9noiwvw |
10.1016/j.mito.2018.08.001 | Biology_easy_393 | A concussion sustained before an earlier concussion has completely resolved typically results in more severe symptoms and prolonged recovery, even if the second impact is less than the first. | Disruption of cellular communication, and the associated increase in cell-autonomous and paracrine signaling by metabokines during the CDR is tightly associated with either a disruption in normal parasympathetic tone from the VVC, or end-organ resistance to cholinergic signals. | The molecular features of this process are universal," said Naviaux, who also directs the Mitochondrial and Metabolic Disease Center at UC San Diego. A concussion sustained before an earlier concussion has completely resolved typically results in more severe symptoms and prolonged recovery, even if the second impact is less than the first. When the abnormal ATP signaling was silenced, the treated boys in the trial displayed dramatically improved communication and social behaviors. | When the CDR is chronically activated, the coordination between the two limbs of the vagus is disrupted. Disruption of cellular communication, and the associated increase in cell-autonomous and paracrine signaling by metabokines during the CDR is tightly associated with either a disruption in normal parasympathetic tone from the VVC, or end-organ resistance to cholinergic signals. Substages of the CDR occur during the transition between a fully active ventral vagus complex in health, its rapid inhibition by CDR1, and its gradual return in CDR3. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=37036494336&p=1pl&v=1&x=fSLbjdg9pAN1rFXsEu2RGA |
10.1016/j.cell.2018.06.045 | Biology_easy_394 | Only small amounts of blood, just a few drops from each baby, are needed to analyse all the white blood cells and hundreds of proteins circulating in the blood. | These data reveal drastic changes across immune components after birth, following a stereotypic pattern shared by all children, but not predictable from cord blood measurements. | "We saw drastic changes in the babies' immune system between each sampling, which shows that it is highly dynamic early in life." Only small amounts of blood, just a few drops from each baby, are needed to analyse all the white blood cells and hundreds of proteins circulating in the blood. The researchers were also able to show that the babies who had abnormal development of the gut flora during the first weeks also demonstrated a disorder of the immune system. | Human systems immunology analyses have now revealed not only large interindividual variation in immune cells and in protein composition but also a stability of phenotypes within individuals over the course of weeks to months , and even a few years (Shen-Orr et al., 2016) . These data reveal drastic changes across immune components after birth, following a stereotypic pattern shared by all children, but not predictable from cord blood measurements. The cell and protein changes occurring imply interactions with microbes as important, and, in a subset of children with gut bacterial dysbiosis, stereotypic immune system development is hampered. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34901466233&p=1pl&v=1&x=3s65PefAzHVGUtcPhREU_Q |
10.1038/s41589-018-0155-8 | Biology_easy_395 | "This is a good example of how the study of a rare genetic disease can reveal a pathway that plays a key role in human biology," says study co-senior author Benjamin Cravatt, professor and chair of the Department of Chemical Physiology at Scripps Research. | 4a and Supplementary Fig. | It also indicates that ABHD12 may be a useful target for drugs that boost the immune system -- for example against cancers and viruses that normally persist by shutting down people's immune defenses. "This is a good example of how the study of a rare genetic disease can reveal a pathway that plays a key role in human biology," says study co-senior author Benjamin Cravatt, professor and chair of the Department of Chemical Physiology at Scripps Research. The team found that in adult mice, reducing ABHD12 activity with the inhibitor led to a rise in lyso-PS in immune cells called macrophages, as well as in brain tissue. | Maximal lyso-PS and 20:4 PS elevations were observed at 30 mg/kg of DO264, which matched the dose at which full ABHD12 inhibition was observed ( Fig. 4a and Supplementary Fig. Time-course studies revealed that the lyso-PS changes caused by DO264 were detectable by 4 h and were maximal at 24 h post dosing ( Fig. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=37814264274&p=1pl&v=1&x=fV_-TrzPs9X1ZtNnkmq4RQ |
10.1373/clinchem.2012.187617 | Biology_easy_396 | One of his eyeballs swelled slightly and his telomeres, special caps on the ends of his DNA strands, also experienced long-term shortening upon return to Earth -- both are phenomena seen generally among space station astronauts. | Manipulation of the gut microbiota may be an important therapeutic strategy to regulate energy balance in individuals who are obese, diabetic, or have a diagnosis of metabolic syndrome. | His cognitive speed and accuracy declined, persisting through six months after he landed. One of his eyeballs swelled slightly and his telomeres, special caps on the ends of his DNA strands, also experienced long-term shortening upon return to Earth -- both are phenomena seen generally among space station astronauts. Overall, NASA views this study as good news so far for their plans of crewed missions to Mars. | These data support a pivotal role for the gut microbiome in the pathogenesis of obesity and obesity-related disorders. Manipulation of the gut microbiota may be an important therapeutic strategy to regulate energy balance in individuals who are obese, diabetic, or have a diagnosis of metabolic syndrome. analyzed bacterial 16S rRNA gene sequences from the cecal microbiota and reported that ob/ob mice had 50% fewer Bacteroidetes and correspondingly more Firmicutes than their lean littermates and this difference was unrelated to differences in food consumption. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=38972928248&p=1pl&v=1&x=ysfCh3UQ1PqOUUs0UQwPzg |
10.1038/nrg2703 | Biology_easy_397 | "It's remarkable that something so random actually ends up working," Jones said. | Lampreys have two VLR genes: VLRA and VLRB . | It just takes one grain to fertilize the female part of a plant, so casting fate to the wind isn't a bad strategy. "It's remarkable that something so random actually ends up working," Jones said. Animals in that environment evolved with pollen all around them. | The majority of variable residues in the VLR are located on the concave surface, which suggests that this surface is involved in antigen binding . Lampreys have two VLR genes: VLRA and VLRB . Both seem to be expressed exclusively in lymphoid cells, and they usually exhibit allelic exclusion. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34307692391&p=1pl&v=1&x=mm-osFSBw9YRNm7JQuxdew |
10.1038/s41467-018-04906-1 | Biology_easy_398 | The researchers believe that their fingerprint sensor is more secure and it even satisfies FBI standards. | In addition, R s of the AgNF-AgNW hybrid electrode decreased further to~0.012 ± 0.0008 Ω/sq with T of 24.11% by increasing their densities. | In theory, this means that user's won't have to worry about where they have to place their finger when they try to unlock their phones. The researchers believe that their fingerprint sensor is more secure and it even satisfies FBI standards. The researchers also claim that the new technology improves current scanning methods by up to 17 percent. | This optoelectronic property was superior to that of other transparent conducting materials, such as ITO (R s >~50 Ω/sq), networks of metal nanowires (R s >~20 Ω/sq), or chemical vapor depositionsynthesized graphene (R s >~100 Ω/sq for undoped cases). In addition, R s of the AgNF-AgNW hybrid electrode decreased further to~0.012 ± 0.0008 Ω/sq with T of 24.11% by increasing their densities. AgNF-AgNW hybrid networks can be photolithographically patterned using wet etching without any significant increase in the resistance, compared to the cases where only singular components of AgNWs or AgNFs were used with no hybrid structure (Fig. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34467889819&p=1pl&v=1&x=bwlU4e1aRXgMmGqDDaSdMA |
10.1002/emmm.201302567 | Biology_easy_399 | Type IV SMA patients have 4 or more copies of the SMN2 gene and don't experience effects of the disease until adulthood. | Compared with neonatal administration, this procedure elicited late-onset motor phenotypes. | People who have 2-3 copies (Type II SMA) make more protein and survive longer, but can never walk. Type IV SMA patients have 4 or more copies of the SMN2 gene and don't experience effects of the disease until adulthood. The flaw in the protein's production is understood. | Here, we have shown that a single injection of an exonskipping ASO into the cerebral ventricles phenocopies adultonset SMA. Compared with neonatal administration, this procedure elicited late-onset motor phenotypes. In adult mice with Smn-null background, the SMN levels required for normal CNS function correspond to an SMN2 copy number less than two, suggesting that only moderate SMN levels are necessary for therapy in adult-onset SMA. | [1] | Biology | train | 1 | news | http://www.healthcanal.com/medical-breakthroughs/42722-first-animal-model-of-adult-onset-sma-sheds-light-on-disease-progression-and-treatment.html |
10.1038/s41467-018-05664-w | Biology_easy_400 | The group also demonstrated a two-qubit holonomic gate to show universality by manipulating the electron-nucleus entanglement. | We also demonstrate a two-qubit holonomic gate to show universality by manipulating the electron−nucleus entanglement. | This method facilitated fast and precise geometric gates at a temperature below 10 K, and the gate fidelity was limited by radiative relaxation," says the corresponding author Hideo Kosaka, Professor, Yokohama National University. The group also demonstrated a two-qubit holonomic gate to show universality by manipulating the electron-nucleus entanglement. The scheme renders a purely holonomic gate without requiring an energy gap, which would have induced dynamic phase interference to degrade the gate fidelity, and thus enables precise and fast control over long-lived quantum memories, for realizing quantum repeaters interfacing between universal quantum computers and secure communication networks. | We also demonstrate a two-qubit holonomic gate to show universality by manipulating the electron−nucleus entanglement. The universal holonomic gates enable fast and fault-tolerant manipulation for realising quantum repeaters interfacing between universal quantum computers and secure communication networks. However, these experiments required microwaves 20 or light waves 24 in two frequencies differing by the energy gap for manipulating the nondegenerate subspace, leading to the degradation of gate fidelity due to the unwanted interference of the dynamic phase. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=34803186941&p=1pl&v=1&x=lE49IeUHg9oYX2lVpw-cqg |
10.1038/s41467-018-02954-1 | Biology_easy_401 | "Embracing such new adaptation pathways will present considerable national scale challenges to planning, development goals and land tenure systems," they said. | Embracing such new adaptation pathways will present considerable national-scale challenges to planning, development goals and land tenure systems. | The study's authors said island nations needed to find creative solutions to adapt to climate change that take into account their homeland's evolving geography. "Embracing such new adaptation pathways will present considerable national scale challenges to planning, development goals and land tenure systems," they said. "However, as the data on island change shows there is time (decades) to confront these challenges." | Not least at issue here is the requirement for significant and continued economic investment, including the development of opportunities for appropriate economic growth and sustained adaptive capacity. Embracing such new adaptation pathways will present considerable national-scale challenges to planning, development goals and land tenure systems. However, as the data on island change show there is time (decades) to confront these challenges, which could engender more thoughtful support from international agencies. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=33251661889&p=1pl&v=1&x=lr0IkZYklRRn8uy2Q7kKrA |
10.1073/pnas.1219361110 | Biology_easy_402 | Female mate choice could have driven the evolution of larger penises in humans." | Our results support the hypothesis that female mate choice could have driven the evolution of larger penises in humans. | And at a certain point in either direction, as witnessed by the 31-year-old virgin, human genitalia can get out of hand. Female mate choice could have driven the evolution of larger penises in humans." "If you picture a bell curve [of penis size], you've got the 95 percent that are normal, and then you have 2.5 percent that are way too big and 2.5 percent that are way too small," Brown explains. | Surprisingly, larger penis size and greater height had almost equivalent positive effects on male attractiveness. Our results support the hypothesis that female mate choice could have driven the evolution of larger penises in humans. More broadly, our results show that precopulatory sexual selection can play a role in the evolution of genital traits. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=34102449597&p=1pl&v=1&x=jQNreBADNzC6cPm_zJjKMA |
10.1083/jcb.201710132 | Biology_easy_403 | "Overall, we think that increased expression of Munc13-4, combined with elevated calcium levels, drives enhanced exosome release by highly aggressive cancer cells, and that Munc13-4 is a potential target for therapeutic intervention," Martin says. | We propose that the increased expression of Munc13-4 in cancer cells after epithelial-to-mesenchymal transition combined with increased Ca 2+ uptake drives enhanced exosome release by highly aggressive cancer cells, and that Munc13-4 is a potential target for therapeutic intervention. | This helps the cancer cells disperse around the body to form secondary metastatic tumors. When Martin and colleagues depleted Munc13-4, they reduced the release of MT1-MMP-containing exosomes from breast cancer cells and inhibited the cells' ability to degrade the extracellular matrix. "Overall, we think that increased expression of Munc13-4, combined with elevated calcium levels, drives enhanced exosome release by highly aggressive cancer cells, and that Munc13-4 is a potential target for therapeutic intervention," Martin says. | This Ca 2+ -, Munc13-4-, and Rab11dependent pathway generated secretion-competent MVBs for basal and Ca 2+ -stimulated CD63 + exosome release. We propose that the increased expression of Munc13-4 in cancer cells after epithelial-to-mesenchymal transition combined with increased Ca 2+ uptake drives enhanced exosome release by highly aggressive cancer cells, and that Munc13-4 is a potential target for therapeutic intervention. The acute (30-min) elevation of intracellular Ca 2+ with ionomycin treatment enhanced CD63 + , CD9 + , and ALIX + exosome release by approximately fivefold in control MDA-MB-231 cells (Fig. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=34362583588&p=1pl&v=1&x=F6YnUwN2LwoCB0GEaW5i4g |
10.1038/s41467-018-04632-8 | Biology_easy_404 | "Our network-centric approach," the researchers wrote, "has exciting potential applicability on diverse intra- and inter-species interactomes, including human protein-protein interaction networks, in efforts to unravel host-pathogen contact points, while fostering the design of targeted therapeutic strategies." | Our network-centric approach has exciting potential applicability on diverse intra-and inter-species interactomes including human PPI networks in efforts to unravel host-pathogen contact points, while fostering the design of targeted therapeutic strategies. | When the internal portions of the cell-surface proteins were tested for interactions with effector proteins from the bacterial pathogen Pseudomonas syringae, the researchers were able to identify seven previously unknown effector targets, a discovery rate of 40 percent. The researchers made mutants of the seven effector targets and found that all of the newly identified targets showed changes in pathogen growth on Arabidopsis plant leaves when mutated. "Our network-centric approach," the researchers wrote, "has exciting potential applicability on diverse intra- and inter-species interactomes, including human protein-protein interaction networks, in efforts to unravel host-pathogen contact points, while fostering the design of targeted therapeutic strategies." | The detailed curation of our Arabidopsis phenotypic dataset can be useful to the scientific community for additional genome-to-phenome studies. Our network-centric approach has exciting potential applicability on diverse intra-and inter-species interactomes including human PPI networks in efforts to unravel host-pathogen contact points, while fostering the design of targeted therapeutic strategies. Therefore, R=(r ij )=[D−A+J]−1. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=34300512407&p=1pl&v=1&x=WKaXG41IVkVX1fiEnqIJcA |
10.1038/ng.3611 | Biology_easy_405 | "This is despite climate change and anthropogenic transformations of local flora and fauna, including changes in agricultural practices, which might have favored the introduction of landraces from other regions that were better adapted to the changing agricultural environment." | This is despite climate change and anthropogenic transformations of local flora and fauna, including changes in agricultural practices , which might have favored the introduction of landraces from other regions that were better adapted to the changing agricultural environment. | "Despite hybridization events between wild and domesticated barleys over the last six millennia, the overall picture is that the genomes of extant Levantine landraces have remained remarkably similar to how they were 6,000 years ago," the scientists explained. "This is despite climate change and anthropogenic transformations of local flora and fauna, including changes in agricultural practices, which might have favored the introduction of landraces from other regions that were better adapted to the changing agricultural environment." "Although we found no indications of major lineage turnovers in the barley crop from the Southern Levant, the eventful history of this region makes it likely that the farmers who grew cereals there several millennia ago are not the ancestors of those who tend the present-day landraces. | Despite hybridization events between wild and domesticated barleys over the last six millennia, the overall picture is that the genomes of extant Levantine landraces have remained remarkably similar to how they were 6,000 years ago. This is despite climate change and anthropogenic transformations of local flora and fauna, including changes in agricultural practices , which might have favored the introduction of landraces from other regions that were better adapted to the changing agricultural environment. Although we found no indications of major lineage turnovers in the barley crop from the Southern Levant (as have, for example, been observed in Near Eastern pig populations 3 ), the eventful history of this region makes it likely that the farmers who grew cereals there several millennia ago are not the ancestors of those who tend the present-day landraces . | [5] | Biology | train | 5 | news | http://feedproxy.google.com/~r/BreakingScienceNews/~3/bVR0QLo50zk/genome-ancient-barley-04034.html |
10.1093/molbev/msw148 | Biology_easy_406 | "These changes are particularly common among dipsadine and colubrine 'higher' snakes." | These changes are particularly common among dipsadine and colubrine "higher" snakes. | However, the team also discovered that the genes have undergone a great amount of evolution, including many changes to the wavelengths of light that the pigments are sensitive to, in order to suit the diversity of lifestyles that snakes have evolved. "These changes are particularly common among dipsadine and colubrine 'higher' snakes." Most snakes examined in the new study are sensitive to UV light, which likely allows them to see well in low light conditions. | These changes are particularly common among dipsadine and colubrine "higher" snakes. All three opsin genes are inferred to be under purifying selection, though dN/dS varies with respect to some lineages, ecologies, and retinal anatomy. Positive selection was inferred at multiple sites in all three opsins, these being concentrated in transmembrane domains and thus likely to have a substantial effect on spectral tuning and other aspects of opsin function. | [5] | Biology | train | 5 | news | http://feedproxy.google.com/~r/BreakingScienceNews/~3/8T9Gokbc0GQ/snake-vision-04206.html |
10.1016/j.bpj.2013.12.017 | Biology_easy_407 | Activation of the immune response is strongest at the center of the rash and clears most, but not all, of the bacteria from the center within about one week; however, bacteria at the edge of the rash continue to spread outward, further activating the immune response away from the edge. | Activation of the innate immune response is strongest at the center of the rash and clears most, but not all, of the bacteria from the center within~1 week. | The model reveals that in these cases, the rash begins as a small and uniform rash. Activation of the immune response is strongest at the center of the rash and clears most, but not all, of the bacteria from the center within about one week; however, bacteria at the edge of the rash continue to spread outward, further activating the immune response away from the edge. Therefore, the rash grows, but the center becomes less inflamed. | 2 g shows a radial slice through a simulated central erythema and shows how the spirochete and macrophage populations change as the rash progresses. Activation of the innate immune response is strongest at the center of the rash and clears most, but not all, of the bacteria from the center within~1 week. Therefore, the rash grows, but the center becomes less inflamed. | [5] | Biology | train | 5 | news | http://www.sciencedaily.com/releases/2014/02/140204123611.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1038/s41467-018-06358-z | Biology_easy_408 | The higher the warming level is, the larger the increase of the burned area is. | The higher the warming level is, the larger is the increase of burned area, ranging from~40% to~100% across the scenarios. | The higher the warming level is, the larger the increase of the burned area is. "These results support the statement of the Paris Agreement (2015) that reports that limiting the temperature increase to 1.5oC would "significantly reduce the risks and impacts of climate change," says the researcher. These fires caused economic and ecological losses, and even human casualties. | In any case, the burned area is robustly projected to increase. The higher the warming level is, the larger is the increase of burned area, ranging from~40% to~100% across the scenarios. Our results indicate that significant benefits would be obtained if warming were limited to well below 2°C. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=37276271626&p=1pl&v=1&x=sVJ0ymJxyzXrlv2GI0KJ4A |
10.1016/j.ajpath.2015.01.024 | Biology_easy_409 | "Importantly, we found necrotizing myelitis and degeneration in the spinal cord, neurodegeneration in the dorsal root ganglia, and demyelination in the nerve roots only when lymphocytic inflammatory lesions were also observed in both the central nervous system and peripheral nervous system," stated Dr. Philipp. | Importantly, we found necrotizing myelitis and degeneration in the spinal cord, neurodegeneration in the DRG, and demyelination in the nerve roots only when lymphocytic inflammatory lesions were also observed in both the CNS and PNS. | Analyses of the differences in the mechanisms of action of both drugs may provide a blueprint for the development of new adjuvant treatments for LNB. "Importantly, we found necrotizing myelitis and degeneration in the spinal cord, neurodegeneration in the dorsal root ganglia, and demyelination in the nerve roots only when lymphocytic inflammatory lesions were also observed in both the central nervous system and peripheral nervous system," stated Dr. Philipp. "Our results suggest that ongoing cytokine activation in the nervous system can contribute to the persistent symptoms of fatigue, pain, and cognitive dysfunction that patients sometimes experience despite having been treated for Lyme disease." | An association between changes in the latency of F-wave frequency, abnormal temporal dispersion, nerve conduction slowing, and the presence of demyelinating neuropathy or axonal damage was documented in several inflammatory demyelinating peripheral neuropathic disorders, including Guillain-Barré syndrome, and LNB. Importantly, we found necrotizing myelitis and degeneration in the spinal cord, neurodegeneration in the DRG, and demyelination in the nerve roots only when lymphocytic inflammatory lesions were also observed in both the CNS and PNS. Ongoing cytokine activation in the nervous system could contribute to the persistent symptoms of fatigue, pain, and cognitive dysfunction that patients sometimes experience despite having been treated for Lyme disease. | [5] | Biology | train | 5 | news | http://www.sciencedaily.com/releases/2015/04/150416084338.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1098/rspb.2018.1807 | Biology_easy_410 | "Each founding event, in fact, was achieved by a subpopulation carrying only a portion of the ancestral population's genetic diversity," the researchers suggest. | Each founding event, in fact, was achieved by a subpopulation carrying only a portion of the ancestral population's genetic diversity. | Instead, the random process of genetic drift meant that as human populations expanded further away from Africa and founded new continents, diversity in birth canals reduced as genetic diversity lessened. "Each founding event, in fact, was achieved by a subpopulation carrying only a portion of the ancestral population's genetic diversity," the researchers suggest. "The signature of these serial founding events is evident in modern populations' genetic variation, whereby genetic diversity decreases with increasing distance from Africa." | The combination of a small founding population size and a quick dispersal meant that a series of genetic bottlenecks accompanied the colonization of new areas of the world. Each founding event, in fact, was achieved by a subpopulation carrying only a portion of the ancestral population's genetic diversity. The signature of these serial founding events is evident in modern populations' genetic variation, whereby genetic diversity decreases with increasing distance from Africa (and number of founding events in the population's history) . | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=37491381304&p=1pl&v=1&x=J_qeWS5Av3SgZGjpwhwr5A |
10.2337/db14-1225 | Biology_easy_411 | aEURoeWe conclude that AMPK-STAT3 axis plays a pivotal role in regulating monocyte-to-macrophage differentiation and that AMPK activators by decreasing STAT3 phosphorylation through increased AMPK activity inhibit monocyte-to-macrophage differentiation,aEUR the authors write. | We conclude that the AMPK-STAT3 axis plays a pivotal role in regulating monocyte-to-macrophage differentiation and that by decreasing STAT3 phosphorylation through increased AMPK activity, AMPK activators inhibit monocyte-tomacrophage differentiation. | Increased AMPK activation with metformin and AICAR decreased STAT3 phosphorylation, causing inhibition of the differentiation of monocytes to macrophages. mice, metformin attenuated Ang-II-induced atheromatous plaque formation and aortic aneurysm, partly by decreasing infiltration of monocytes. aEURoeWe conclude that AMPK-STAT3 axis plays a pivotal role in regulating monocyte-to-macrophage differentiation and that AMPK activators by decreasing STAT3 phosphorylation through increased AMPK activity inhibit monocyte-to-macrophage differentiation,aEUR the authors write. | Metformin attenuated Ang-II-induced atheromatous plaque formation and aortic aneurysm in ApoE 2/2 mice partly by reducing monocyte infiltration. We conclude that the AMPK-STAT3 axis plays a pivotal role in regulating monocyte-to-macrophage differentiation and that by decreasing STAT3 phosphorylation through increased AMPK activity, AMPK activators inhibit monocyte-tomacrophage differentiation. AMPK activity was dose and time dependently downregulated during phorbol myristate acetate (PMA)-induced monocyteto-macrophage differentiation, which was accompanied by an upregulation of proinflammatory cytokine production. | [5] | Biology | train | 5 | news | http://healthmedicinet.com/news/metformins-potential-role-in-atherosclerosis-explored/ |
10.1038/emi.2013.60 | Biology_easy_412 | According to the paper, the towns and villages that constituted research sites for the study are likely similar to hundreds or even thousands of sites throughout Asia, where humans live alongside macaques accustomed to their presence. | The towns and villages that constituted research sites for our study are likely similar to hundreds or even thousands of sites throughout Asia, where humans live alongside synanthropic macaques. | Jones-Engel said long-term surveillance is needed in the areas where humans and primates come into contact since it's unlikely that SIV/HIV will be the last primate virus to emerge into the human population. According to the paper, the towns and villages that constituted research sites for the study are likely similar to hundreds or even thousands of sites throughout Asia, where humans live alongside macaques accustomed to their presence. The research team found that zoonotic transmission of SFV occurred most commonly through bites. | Human/NHP interface in Asia differs from that in Africa The data presented here expand our knowledge of cross-species transmission of SFV in Asia. The towns and villages that constituted research sites for our study are likely similar to hundreds or even thousands of sites throughout Asia, where humans live alongside synanthropic macaques. [1] [2] [] In contrast to Africa, where bushmeat hunting and habitat degradation threaten to deplete NHP populations over the next decades, 4, 5 some synanthropic primate populations in Asia have actually thrived, and continue to be sustainable, in spite of the pressures presented by increasing human populations. | [5] | Biology | train | 5 | news | http://www.sciencedaily.com/releases/2013/09/130904105343.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1038/s41467-019-08895-7 | Biology_easy_413 | "These observations are compelling, as circulating myo-miRs are not only a bio-marker, but also a functional constituent of the intricate crosstalk between the ischemic heart and the remote bone marrow organ." | These observations are compelling, as circulating myo-miRs are not only a bio-marker, but also a functional constituent of the intricate crosstalk between ischemic heart and the remote BM organ. | "Our work reveals that exosomes released from the ischemic heart are in fact mediating the systemic response of bone marrow progenitor cells to the site of injury," the researchers reported. "These observations are compelling, as circulating myo-miRs are not only a bio-marker, but also a functional constituent of the intricate crosstalk between the ischemic heart and the remote bone marrow organ." "Because of the critical role of bone marrow progenitor cells in the ischemic tissue repair," they said, "the mechanism identified in this study could be an important component of the physiological response to ischemic injury and thus could be leveraged for treatment of ischemic heart disease." | Our work reveals that exosomes released from the ischemic heart are in fact mediating the systemic response of BM PCs to the site of injury. These observations are compelling, as circulating myo-miRs are not only a bio-marker, but also a functional constituent of the intricate crosstalk between ischemic heart and the remote BM organ. In this study we found exosomes mediate transfer of myo-miRs to BM. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=38754070826&p=1pl&v=1&x=PCjC6TW6cIdpBWUFKRqAIA |
10.1093/conphys/cot032 | Biology_easy_414 | Dr Knapp says, "The biological effects of altered biochemical concentrations may not be manifested over a short time period, but could have deleterious effects on long-term fitness and population stability." | The biological effects of altered biochemical concentrations may not be manifested over a short time period, but could have deleterious impacts on long-term fitness and population stability. | Similarly, the higher uric acid levels in male and female iguanas could be the result of animal protein, such as ground beef, being fed to iguanas by tourists. Dr Knapp says, "The biological effects of altered biochemical concentrations may not be manifested over a short time period, but could have deleterious effects on long-term fitness and population stability." While the researchers acknowledge that increased population density as a result of tourist-feeding can be beneficial for endangered species, they warn that unnaturally high densities and excessive reliance on tourists for food may prove problematic if food supplementation is discontinued for any reason. | We stress the importance of this intra-specific comparison instead of solely evaluating published references. The biological effects of altered biochemical concentrations may not be manifested over a short time period, but could have deleterious impacts on long-term fitness and population stability. For example, food provisioning of garden birds can have important downstream consequences, such as smaller relative yolk mass in larger eggs and reduced yolk carotenoid concentrations in early breeders . | [5] | Biology | train | 5 | news | http://www.sciencedaily.com/releases/2013/12/131205220120.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1098/rspb.2014.0161 | Biology_easy_415 | "This conflicts with the basic tenet that science neither rejects nor accepts anything without examining the evidence. | This conflicts with the basic tenet that science neither rejects nor accepts anything without examining the evidence. | The study's authors are willing to give cryptozoologists their day in the sun. "This conflicts with the basic tenet that science neither rejects nor accepts anything without examining the evidence. At first pass, this justification seems to open up a world of fascinating research. | Two Himalayan samples, one from Ladakh, India, the other from Bhutan, had their closest genetic affinity with a Palaeolithic polar bear, Ursus maritimus. This conflicts with the basic tenet that science neither rejects nor accepts anything without examining the evidence. , after analysis of a Nepalese sample, confirmed Captain Haddock's suspicions that the yeti was an ungulate [7] . | [5] | Biology | train | 5 | news | http://www.thedailybeast.com/articles/2014/07/03/sorry-bigfoot-truthers-yetis-aren-t-real.html |
10.1126/sciadv.aar8534 | Biology_easy_416 | "Animal feed imports have increased 49 times, total ammonia and GHG emissions to the atmosphere doubled, and nitrogen losses to watercourses tripled," he adds. | In the same period, animal feed imports have increased 49 times, total ammonia and GHG emissions to the atmosphere doubled, and nitrogen losses to watercourses tripled. | "However, the costs of livestock transition are also large," says Lin Ma, the paper's corresponding author, also at the CAS institute. "Animal feed imports have increased 49 times, total ammonia and GHG emissions to the atmosphere doubled, and nitrogen losses to watercourses tripled," he adds. "This new transition must be induced by government, processing industry, consumers and retailers," stresses Ma. | Production of animal source protein increased 4.9 times, nitrogen use efficiency at herd level tripled, and average feed use and GHG emissions per gram protein produced decreased by a factor of 2 between 1980 and 2010. In the same period, animal feed imports have increased 49 times, total ammonia and GHG emissions to the atmosphere doubled, and nitrogen losses to watercourses tripled. Forecasts for 2050, using the Shared Socio-economic Pathways scenarios, indicate major further changes in livestock production and impacts. | [5] | Biology | train | 5 | news | http://www.seeddaily.com/reports/Chinas_livestock_revolution_demands_new_transition_999.html |
10.1038/nbt.2488 | Biology_easy_417 | Recon 2 will facilitate many future biomedical studies and is freely available here. | Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/. | "The results provide a framework that will lead to a better understanding of how an individual's lifestyle, such as diet, or a particular drug they may require is likely to affect them according to their specific genetic characteristics," he added. "The model takes us an important step closer to what is termed 'personalized medicine', where treatments are tailored according to the patient's genetic information." Recon 2 will facilitate many future biomedical studies and is freely available here. | Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/. r e s o u r c e of interest to the community of researchers focused on the systems biology of metabolism of a target organism. | [5] | Biology | train | 5 | news | http://www.redorbit.com/news/health/1112795467/recon-metabolism-map-created-by-researchers-030413/ |
10.1016/j.cell.2018.05.009 | Biology_easy_418 | "Buffering against acidification or inhibiting lactic acid production fully rescues circadian oscillation." | Buffering against acidification or inhibiting lactic acid production fully rescues circadian oscillation. | "Unexpectedly, we uncover a profound disruption of the circadian clock and diurnal transcriptome when hypoxic cells are permitted to acidify to recapitulate the tumor microenvironment," the article states. "Buffering against acidification or inhibiting lactic acid production fully rescues circadian oscillation." The study's authors, led by Chi Van Dang, M.D., Ph.D., scientific director of the Ludwig Institute for Cancer Research, conclude that acid produced during the cellular metabolic response to hypoxia suppresses the circadian clock through diminished translation of clock constituents. | Unexpectedly, we uncover a profound disruption of the circadian clock and diurnal transcriptome when hypoxic cells are permitted to acidify to recapitulate the tumor microenvironment. Buffering against acidification or inhibiting lactic acid production fully rescues circadian oscillation. We find that acid drives peripheral redistribution of normally perinuclear lysosomes away from perinuclear RHEB, thereby inhibiting the activity of lysosome-bound mTOR. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=34189804817&p=1pl&v=1&x=xIGbl9v-d2xQx6UL7EdZ5Q |
10.1098/rspb.2017.1219 | Biology_easy_419 | It includes most of the giant species of titanosaurs and represents the major increase in body mass in the history of Titanosauria. | This clade includes most of the giant species of titanosaurs and represents the major increase in body mass in the history of Titanosauria. | The team's analysis also revealed the presence of a previously unrecognized diverse lineage of Patagonian titanosaurs. It includes most of the giant species of titanosaurs and represents the major increase in body mass in the history of Titanosauria. "The phylogenetic study we performed indicates that most of the giant titanosaurs known in Patagonia belong to a single lineage," Dr. Pol said. | Its inclusion in an extended phylogenetic analysis and the optimization of body mass reveals the presence of an endemic clade of giant titanosaurs inhabited Patagonia between the Albian and the Santonian. This clade includes most of the giant species of titanosaurs and represents the major increase in body mass in the history of Titanosauria. In addition to their taxonomic diversity (approx. | [5] | Biology | train | 5 | news | http://feedproxy.google.com/~r/BreakingScienceNews/~3/mZxcd1LOqx8/patagotitan-mayorum-05121.html |
10.1038/ncomms4406 | Biology_easy_420 | However, the small absorption overlap with the solar spectrum limits the photocurrent generation in fullerene acceptors, and their deep energy level for electron conduction limits the open-circuit voltage. | However, the small absorption overlap with the solar spectrum limits the photocurrent generation in fullerene acceptors. | Secondly, high short-circuit currents were achieved by developing a multilayer device structure of three active semiconductor layers with complementary absorption spectra, and an efficient exciton harvesting mechanism. However, the small absorption overlap with the solar spectrum limits the photocurrent generation in fullerene acceptors, and their deep energy level for electron conduction limits the open-circuit voltage. Imec implemented two fullerene-free materials as acceptor, increasing open-circuit voltages compared to OPV cells with fullerene acceptors. | These results confirm that multilayer cascade structures are a promising alternative to conventional donor-fullerene organic solar cells. However, the small absorption overlap with the solar spectrum limits the photocurrent generation in fullerene acceptors. 17) , which is comparable to the best bilayer SubPc/C 60 cells reported in the literature 19 . | [5] | Biology | train | 5 | news | http://www.nanowerk.com/nanotechnology_news/newsid=34710.php |
10.1038/s41467-018-06124-1 | Biology_easy_421 | The process is suitable for the synthesis of free standing GaPO 4 nanosheets. | The developed printing process is also suitable for the synthesis of free standing GaPO 4 nanosheets. | APPLICATIONS
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The new process is simple, scalable, low-temperature and cost effective, significantly expanding the range of materials available to industry at such scales and quality. The process is suitable for the synthesis of free standing GaPO 4 nanosheets. The low temperature synthesis method is compatible with a variety of electronic device fabrication procedures, providing a route for the development of future 2D piezoelectric materials. | The unit cell thick nanosheets present a large effective out-of-plane piezoelectric coefficient of 7.5 ± 0.8 pm V −1 . The developed printing process is also suitable for the synthesis of free standing GaPO 4 nanosheets. The low temperature synthesis method is compatible with a variety of electronic device fabrication procedures, providing a route for the development of future 2D piezoelectric materials. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=37024124114&p=1pl&v=1&x=lMlK1R0_PaYXwsSegEUkBA |
10.1111/1755-0998.12987 | Biology_easy_422 | Because the concentration of eDNA in stream water results from both the amount of DNA shed by fish and the flow of water, the product of eDNA concentration and streamflow can be used to calculate absolute quantities of eDNA, Levi said. | Because the concentration of eDNA in streamwater results from both the amount of DNA shed by organisms and the flow of water, the product of eDNA concentration and streamflow (measured in units of water volume per time) can be used to calculate absolute quantities of eDNA per unit time. | "This is a major first step for more informed salmon management decisions because it opens up the possibility to affordably monitor many more streams than the few that are currently monitored." Because the concentration of eDNA in stream water results from both the amount of DNA shed by fish and the flow of water, the product of eDNA concentration and streamflow can be used to calculate absolute quantities of eDNA, Levi said. The counts derived from eDNA were remarkably similar both for returning adult salmon and out-migrating juveniles" Levi said. | than simply accumulating as fish enter a watershed, eDNA concentrations might spike up and down as a pulse of fish swims past a sampling point, with the size of the spike correlated with fish number and/or biomass. Because the concentration of eDNA in streamwater results from both the amount of DNA shed by organisms and the flow of water, the product of eDNA concentration and streamflow (measured in units of water volume per time) can be used to calculate absolute quantities of eDNA per unit time. If, for instance, juveniles rear sufficiently far upstream, the signal of their eDNA should be weak or undetectable, eliminating a source of noise that would prevent the robust enumeration of adult salmon entering lower stream reaches with eDNA. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=38147506572&p=1pl&v=1&x=poM5RDff3I6ZMJ5l_Scmkg |
10.1098/rspb.2015.1014 | Biology_easy_423 | "Our discovery of this elastic tongue micropump could inspire applications, and the study of flow, in elastic-walled tubes in both biological and artificial systems," the scientists concluded. | Our discovery of this elastic tongue micropump could inspire applications, and the study of flow, in elastic-walled (flexible) tubes in both biological and artificial systems. | That energy subsequently facilitates the pumping of more nectar. "Our discovery of this elastic tongue micropump could inspire applications, and the study of flow, in elastic-walled tubes in both biological and artificial systems," the scientists concluded. _____
Alejandro Rico-Guevara et al. | The new explanation of the mechanics of nectar uptake we provide here suggests that physical constraints are the main determinants of the relationship between pollinator type and nectar concentration, and can guide us through alternative hypotheses of hummingbird-flower coevolution. Our discovery of this elastic tongue micropump could inspire applications, and the study of flow, in elastic-walled (flexible) tubes in both biological and artificial systems. B 282: 20151014 entrance with respect to the nectar chamber. | [5] | Biology | train | 5 | news | http://www.sci-news.com/biology/science-hummingbird-tongue-micropump-03146.html |
10.7717/peerj.19 | Biology_easy_425 | Teller found that the sleight happened so quickly he himself did not realize he had loaded the cup. | In fact, Teller found that the sleight happened so quickly he himself did not realize he had loaded the transparent cup. | The falling ball was so compelling that it drew his own attention away from his other hand, which was deftly and secretly loading a second ball under the glass. Teller found that the sleight happened so quickly he himself did not realize he had loaded the cup. He surmised he missed it because the falling ball captured his attention. | The falling ball was so compelling that it even drew his own attention away from his other hand, which was deftly and automatically loading a second ball under the glass (he was so well practiced that he no longer needed to consciously control his hands). In fact, Teller found that the sleight happened so quickly he himself did not realize he had loaded the transparent cup. Teller further realized that all of this took place despite the fact that he should have been able to see the secret ball as it was loaded under the cup. | [5] | Biology | train | 5 | news | http://www.insidescience.org/content/ancient-magical-illusion-even-more-effective-magicians-may-realize/935 |
10.1126/sciadv.aaq0883 | Biology_easy_426 | "We do not deny that large flows of asylum seekers into Europe pose many political challenges both within host countries and with respect to the European coordination of national policies. | We do not deny that large flows of asylum seekers into Europe pose many political challenges both within host countries and with respect to the European coordination of national policies. | "Our results suggest that the alleged migrant crisis currently experienced by Europe is not likely to provoke an economic crisis but might rather be an economic opportunity," the researchers concluded. "We do not deny that large flows of asylum seekers into Europe pose many political challenges both within host countries and with respect to the European coordination of national policies. However, these political challenges may be more easily addressed if the cliche that international migration is associated with economic burden can be dispelled." | Year 1 rather be an economic opportunity. We do not deny that large flows of asylum seekers into Europe pose many political challenges both within host countries and with respect to the European coordination of national policies. However, these political challenges may be more easily addressed if the cliché that international migration is associated with economic "burden" can be dispelled. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=34353922261&p=1pl&v=1&x=HWJQ-179iZnBFBu4vGwVbw |
10.1098/rsbl.2013.0120 | Biology_easy_427 | Further studies will build on this research to assess how widespread behavioural inheritance is for personality traits across other species. | Further studies are needed to assess how widespread this mode of inheritance is for personality traits across species. | Although this study considers personality inheritance in zebra finches, it raises questions about the inheritance of personality in other species, including humans. The results of this study indicate that non-genetic transmission of behaviour can play an important role in shaping animal personality. Further studies will build on this research to assess how widespread behavioural inheritance is for personality traits across other species. | population density) vary predictably and stably across generations but not so long that genetically determined behaviours predominate. Our study provides evidence that personality traits can be nongenetically inherited, via behavioural transmission, in zebra finches. Further studies are needed to assess how widespread this mode of inheritance is for personality traits across species. | [5] | Biology | train | 5 | news | http://www.sciencedaily.com/releases/2013/06/130605090524.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1126/science.aan2329 | Biology_easy_428 | "This discovery supports colonial nesting behavior and potential nesting site fidelity in the Pterosauria." | This discovery supports colonial nesting behavior and potential nesting site fidelity in the Pterosauria. | "The geological context, including at least four levels with embryos and eggs, indicates that this deposit was formed by a rare combination of events, with storms acting on a nesting ground," researchers reported in their study. "This discovery supports colonial nesting behavior and potential nesting site fidelity in the Pterosauria." ''The work is a crucial advance in understanding pterosaur reproduction,'' said Charles Deeming, from the University of Lincoln. | The geological context, including at least four levels with embryos and eggs, indicates that this deposit was formed by a rare combination of events, with storms acting on a nesting ground. This discovery supports colonial nesting behavior and potential nesting site fidelity in the Pterosauria. The specimens can be attributed to Hamipterus tianshanensis, the sole species in this bonebed. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=32659471801&p=1pl&v=1&x=O3ePTt4rZsKTDZMm6Zr1VA |
10.1016/j.nutres.2019.03.004 | Biology_easy_429 | RNA sequencing expression profiling revealed that expression of 456 identified genes was significantly changed in the tumor due to walnut consumption. | RNA sequencing expression profiling revealed that expression of 456 identified genes was significantly changed in the tumor due to walnut consumption. | Pathological studies confirmed that lumps were breast cancer in all women who remained in the trial. RNA sequencing expression profiling revealed that expression of 456 identified genes was significantly changed in the tumor due to walnut consumption. Ingenuity Pathway Analysis showed activation of pathways that promote apoptosis and cell adhesion and inhibition of pathways that promote cell proliferation and migration. | Pathological studies confirmed that lumps were breast cancer in all women who remained in the trial. RNA sequencing expression profiling revealed that expression of 456 identified genes was significantly changed in the tumor due to walnut consumption. Ingenuity Pathway Analysis showed activation of pathways that promote apoptosis and cell adhesion, and inhibition of pathways that promote cell proliferation and migration. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=38864633495&p=1pl&v=1&x=9kb1spTs1kP4Fpl1LuDBvQ |
10.1002/stem.2883 | Biology_easy_431 | "Overall, our study affirms that light-responsive retinal organoids derived from carefully selected and differentiation efficient iPSC lines can be generated at a scale needed for pharmacology and drug screening purposes." | Together our data indicate that light responsive retinal organoids derived from carefully selected and differentiation efficient iPSC lines can be generated at the scale needed for pharmacology and drug screening purposes. | "Seeding density and nutrient availability seemed to have had the most dominant effect on retinal organoid formation. "Overall, our study affirms that light-responsive retinal organoids derived from carefully selected and differentiation efficient iPSC lines can be generated at a scale needed for pharmacology and drug screening purposes." By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices. | We tested the response of iPSC-derived retinal organoids to Moxifloxacin and showed that similarly to in vivo adult mouse retina, the primary affected cell types were photoreceptors. Together our data indicate that light responsive retinal organoids derived from carefully selected and differentiation efficient iPSC lines can be generated at the scale needed for pharmacology and drug screening purposes. Hallam and colleagues show herein that generation of retinal organoids from human iPSC is efficient, reliable and scalable. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=34736794934&p=1pl&v=1&x=kDwuobeOawEn0gntPOc4ng |
10.1128/jb.01589-14 | Biology_easy_432 | The results reinforce the notion that survival after high doses of ionizing radiation does not depend on a single mechanism or process, but instead is multifaceted. | The results reinforced the notion that survival after high doses of ionizing radiation does not depend on a single mechanism or process, but instead is multifaceted. | The 46 genes did not result from the mutations created under high radiation levels, but rather genes that exist in the normal, wild-type E. coli. The results reinforce the notion that survival after high doses of ionizing radiation does not depend on a single mechanism or process, but instead is multifaceted. "We established a role for genes involved in processes as diverse as central metabolism and the synthesis and maintenance of the cell wall in radiation survival," says Cox. | Forty-six genes were identified, most of which become essential upon heavy IR exposure. The results reinforced the notion that survival after high doses of ionizing radiation does not depend on a single mechanism or process, but instead is multifaceted. However, contributions by genes involved in cell wall structure/function, cell division, and intermediary metabolism were also evident. | [5] | Biology | train | 5 | news | http://www.sciencedaily.com/releases/2014/07/140721123825.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1038/s41467-019-09945-w | Biology_easy_433 | Yield increase is therefore shown to be more effective in reducing land use when combined with land use regulation and consumption changes. | Yield increase is therefore shown to be more effective in reducing land use when combined with land-use regulation and consumption changes. | The study adds an extra level of understanding to how the different options above interact, and how best to combine them. Yield increase is therefore shown to be more effective in reducing land use when combined with land use regulation and consumption changes. The researchers say that the study is an important milestone for the research community as it will help to elaborate more consistent quantitative scenarios across studies, and ease the comparability of results for policy guidance on all major sustainability challenges related to land use, including climate change impact and mitigation, biodiversity, and food security. | Furthermore, this study adds an analysis of interactions between factors: an increase in agricultural efficiency can reduce demand for cropland but can also trigger higher demand. Yield increase is therefore shown to be more effective in reducing land use when combined with land-use regulation and consumption changes. Consumption changes, better land management, and increased agricultural productivity therefore appear robust and effective measures to reduce the demand for agricultural land, in particular when bundled together. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=39240053352&p=1pl&v=1&x=b5ez99X_WY5QWY7Dbe1_4g |
10.1038/s41556-019-0333-2 | Biology_easy_434 | Our pathway-inhibition paradigm thus opens an avenue for generating mammalian pluripotent stem cells, and EPSCs present a unique cellular platform for translational research in biotechnology and regenerative medicine." | Our pathway-inhibition paradigm thus opens an avenue for generating mammalian pluripotent stem cells, and EPSCs present a unique cellular platform for translational research in biotechnology and regenerative medicine. | Importantly, trophoblast stem-cell-like cells can be generated from both human and porcine EPSCs. Our pathway-inhibition paradigm thus opens an avenue for generating mammalian pluripotent stem cells, and EPSCs present a unique cellular platform for translational research in biotechnology and regenerative medicine." The study is the first time scientists have been able to derive stem cells from early pig embryos, noted the scientists. | Importantly, trophoblast stem-cell-like cells can be generated from both human and porcine EPSCs. Our pathway-inhibition paradigm thus opens an avenue for generating mammalian pluripotent stem cells, and EPSCs present a unique cellular platform for translational research in biotechnology and regenerative medicine. Our results demonstrate that porcine EPSCs could be established and, importantly, that similar culture conditions permit derivation of human EPSCs. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=39384948574&p=1pl&v=1&x=kJohdbe65Giukna_tHVVgg |
10.1186/s12974-019-1453-0 | Biology_easy_435 | Nonetheless, the immune response is deeply tied to the development of pathology, and with advancing technologies, we are able to more fully dissect the complexity of this response and the effector cells that carry it out. | Nonetheless, the immune response is deeply tied to the development of pathology, and with advancing technologies, we are able to more fully dissect the complexity of this response and the effector cells that carry it out. | These peripheral immune cells can aid in amyloid b clearance or modulate microglia responses, depending on the cell type. Nonetheless, the immune response is deeply tied to the development of pathology, and with advancing technologies, we are able to more fully dissect the complexity of this response and the effector cells that carry it out. Our knowledge of how microglia and peripheral immune cells interact has proved invaluable in understanding how this delicate balance goes awry in disease. | Treatment of amyloidogenic murine models with pioglitazone, a direct agonist of PPARγ, reduces amyloid β 1-42 deposits in the hippocampus . Nonetheless, the immune response is deeply tied to the development of pathology, and with advancing technologies, we are able to more fully dissect the complexity of this response and the effector cells that carry it out. Our knowledge of how microglia and peripheral immune cells interact has proved invaluable in understanding how this delicate balance goes awry in disease. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=38978630439&p=1pl&v=1&x=9aaycFjKC6olbnBiXp14ng |
10.1126/sciadv.1501675 | Biology_easy_436 | "This suggests that if future habitat loss is prevented, the tiger recovery in some range states will accelerate. | This suggests that if future habitat loss is prevented, the tiger recovery now underway in some range states will accelerate. | "Most encouraging was that loss was less than expected in the 51 tiger reserves," wrote the authors in the paper. "This suggests that if future habitat loss is prevented, the tiger recovery in some range states will accelerate. In these promising locales of enhanced protection, a doubling of the tiger population could be attainable by 2022." | Most encouraging was that loss was less than expected in the 51 tiger reserves that serve as source sites in the priority landscapes. This suggests that if future habitat loss is prevented, the tiger recovery now underway in some range states will accelerate. In these promising locales of enhanced protection, a doubling of the tiger population could be attainable by 2022. | [5] | Biology | train | 5 | news | http://www.redorbit.com/news/science/1113413447/could-tiger-populations-recover-these-scientists-say-yes-040316/ |
10.1016/j.vaccine.2014.05.010 | Biology_easy_437 | This finding is consistent with the fact that the spleen is amongst the most important organs for filtering out foreign agents and is the main organ for antigen presentation in teleost fish. | This finding is consistent with the fact that the spleen is amongst the most important organs for filtering out foreign agents and is the main organ for antigen presentation in teleost fish . | This finding is consistent with the fact that the spleen is amongst the most important organs for filtering out foreign agents and is the main organ for antigen presentation in teleost fish. The level of protection observed in the fish treated with NLc liposomes, regardless of the administration route, suggests the potential utility of these liposomes as a broad-spectrum tool for immunological protection of fish. Furthermore, the fact that the mixture of free immunostimulants did not offer protection in any of the infection models underscores the importance of encapsulating in liposomes to ensure optimal activation of the immune system. | injection clearly indicated that the spleen was the main organ in which the liposomes had accumulated. This finding is consistent with the fact that the spleen is amongst the most important organs for filtering out foreign agents and is the main organ for antigen presentation in teleost fish . Furthermore, with NLc liposomes were also challenged with PAO1 one month after immunostimulation. | [5] | Biology | train | 5 | news | http://www.nanowerk.com/nanotechnology-news/newsid=36056.php |
10.1021/cb4008953 | Biology_easy_438 | "This highlights the potential for devising new antimalarial therapies that exploit inherent weaknesses in a key resistance mechanism of P. falciparum," they state. | This highlights the potential for devising new antimalarial therapies that exploit inherent weaknesses in a key resistance mechanism of P. falciparum. | This resensitizes the parasites to chloroquine, and appears to block the normal function of the resistance protein, killing the parasite. "This highlights the potential for devising new antimalarial therapies that exploit inherent weaknesses in a key resistance mechanism of P. falciparum," they state. | Moreover, the additional parasiticidal effect exerted by 1 and 6 in the drug-resistant parasites was attributable, at least in part, to their ability to inhibit PfCRT CQR . This highlights the potential for devising new antimalarial therapies that exploit inherent weaknesses in a key resistance mechanism of P. falciparum. This phenomenon is thought to be due to an increase in the efflux of the drug from the DV, a decrease in its uptake into the DV, or a combination of both. | [5] | Biology | train | 5 | news | http://www.sciencedaily.com/releases/2014/01/140115122211.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1016/j.cub.2014.10.014 | Biology_easy_440 | 'In my opinion, the more subtle perspective we offer could have important implications for decision-making in both the boardroom and the classroom. | The more subtle perspective we offer could have important implications for decision making in both the boardroom and the classroom. | 'It shows the positive side of social dominance.' 'In my opinion, the more subtle perspective we offer could have important implications for decision-making in both the boardroom and the classroom. For example if you are trying to help a leader to learn something new it may be important to consider whether they are socially or aggressively dominant, and whether they will best learn via a social or individual route.' | This paper presents the first study of dominance and social learning in humans and challenges the lay stereotype in which all dominant individuals ignore others' views . The more subtle perspective we offer could have important implications for decision making in both the boardroom and the classroom. In experiment 1, adult participants (n = 33; age mean = 27.88, SEM = 1.39; 19 males, 14 females; Table S1 available have demonstrated that individuals who score high in either SD or AD, on the scales we employed, have strong beliefs about the importance of individual accountability and self-report high levels of self-esteem, authoritarianism, and self-sufficiency . | [5] | Biology | train | 5 | news | http://www.sciencedaily.com/releases/2014/11/141120123051.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1038/s41467-018-04863-9 | Biology_easy_441 | PRMT5 pharmacological inhibition, CRISPR-cas9 targeting, or genetic ablation decrease p53-dependent survival and impair differentiation without affecting proliferation. | PRMT5 pharmacological inhibition, CRISPR/cas9 targeting, or genetic ablation decrease p53-dependent survival and impair differentiation without affecting proliferation. | PRMT5 pharmacological inhibition, CRISPR-cas9 targeting, or genetic ablation decrease p53-dependent survival and impair differentiation without affecting proliferation. Conditional ablation of Prmt5 in progenitors results in hypomyelination, reduced survival, and differentiation. "Data obtained using purified histones further validate the results obtained in mice and in cultured oligodendrocyte progenitors. | PRMT5 pharmacological inhibition, CRISPR/cas9 targeting, or genetic ablation decrease p53-dependent survival and impair differentiation without affecting proliferation. Conditional ablation of Prmt5 in progenitors results in hypomyelination, reduced survival and differentiation. Decreased histone H4R3 symmetric methylation is followed by increased nuclear acetylation of H4K5, and is rescued by pharmacological inhibition of histone acetyltransferases. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=34581587669&p=1pl&v=1&x=ItNrPiAOfGTQKOiU8pm4UA |
10.1093/icesjms/fsw166 | Biology_easy_442 | "Our findings provide evidence that temperate marine reserves can deliver fisheries and conservation benefits, but they also highlight the importance of investigating multi-species interactions, as the recovery of some species can have knock-on effects on others," says Bryce Beukers-Stewart, a lecturer in the University of York's environment department and supervisor of the study. | Our findings provide evidence that temperate marine reserves can deliver fisheries and conservation benefits, and highlight the importance of investigating multispecies interactions, as the recovery of some species can have knock-on effects on others. | This could be due to the relatively small size of the Lamlash Bay reserve, showing that larger reserves are needed to allow marine ecosystems to recover more naturally. "Our findings provide evidence that temperate marine reserves can deliver fisheries and conservation benefits, but they also highlight the importance of investigating multi-species interactions, as the recovery of some species can have knock-on effects on others," says Bryce Beukers-Stewart, a lecturer in the University of York's environment department and supervisor of the study. However, our research within Lamlash Bay has shown that a wide range of species and habitats can benefit from protection. | Interestingly, catches of adult lobsters were inversely correlated with those of juvenile lobsters, brown crabs, and velvet crabs, which may be evidence of competitive displacement and/or predation. Our findings provide evidence that temperate marine reserves can deliver fisheries and conservation benefits, and highlight the importance of investigating multispecies interactions, as the recovery of some species can have knock-on effects on others. If populations are to benefit from the protection afforded by MPAs, it is necessary that a number of individuals spend a substantial part of their lives within their boundaries . | [5] | Biology | train | 5 | news | http://www.futurity.org/marine-reserve-lobsters-1261382-2/ |
10.1007/s00125-016-4065-6 | Biology_easy_443 | The patients in the intensive-therapy group survived for a median of eight years longer than the conventional-therapy group patients. | The patients in the intensivetherapy group survived for a median of 7.9 years longer than the conventional-therapy group patients. | Longer lives
At the follow-up 21 years after the initiation of the study, 38 intensive-therapy patients versus 55 conventional-therapy patients had died (meaning the original intensively treated patients were 45 percent less likely to die). The patients in the intensive-therapy group survived for a median of eight years longer than the conventional-therapy group patients. Importantly, median time before first cardiovascular event after randomization was also eight years longer in the original intensive-therapy group meaning that the additional eight years of life is likely to correspond to the extra eight years free of new cardiovascular complications. | Results Thirty-eight intensive-therapy patients vs 55 conventional-therapy patients died during follow-up (HR 0.55 [95% CI 0.36, 0.83], p = 0.005). The patients in the intensivetherapy group survived for a median of 7.9 years longer than the conventional-therapy group patients. Median time before first cardiovascular event after randomisation was 8.1 years longer in the intensive-therapy group (p = 0.001). | [5] | Biology | train | 5 | news | http://www.futurity.org/diabetes-microalbuminura-1245772-2/ |
10.1098/rsbl.2017.0299 | Biology_easy_445 | The research suggests, in contrast to expectations, "the rapid global range expansion of true frogs was not associated with increased net-diversification." | Interestingly, and in striking contrast to expectations, the rapid global range expansion of true frogs was not associated with increased net diversification. | Not so for "true frogs," the research indicates. The research suggests, in contrast to expectations, "the rapid global range expansion of true frogs was not associated with increased net-diversification." "We found a distinct pattern. | We detected no shifts in extinction rates, nor signatures of mass extinction (electronic supplementary material, figure S3 ). Interestingly, and in striking contrast to expectations, the rapid global range expansion of true frogs was not associated with increased net diversification. On the contrary, diversification rates either decreased or remained unchanged, even as remarkable, circumglobal range expansion via dispersal and colonization of novel regions occurred. | [5] | Biology | train | 5 | news | http://www.futurity.org/true-frogs-evolution-1546132/ |
10.1016/j.devcel.2014.11.012 | Biology_easy_446 | The researchers also found that senescent cells were present only for a short time during tissue repair, in contrast to the persistent presence of senescent cells in aged or chronically damaged tissues. | Notably, senescent cells were present only transiently during tissue repair, in contrast to the persistent presence of senescent cells in aged or chronically damaged tissues. | "It rescued delayed wound closure and allowed the mice to heal normally." The researchers also found that senescent cells were present only for a short time during tissue repair, in contrast to the persistent presence of senescent cells in aged or chronically damaged tissues. Moreover, they say the fact that PDGF-AA was activated very early upon senescence induction in cell culture suggests the time-dependent regulation of secretory factors might, in part, explain the beneficial vs. deleterious effects of senescent cells. | In contrast to the well-documented deleterious effects of senescent cells and the SASP, the results presented here unambiguously demonstrate a positive role for senescent cells and the SASP in tissue repair. Notably, senescent cells were present only transiently during tissue repair, in contrast to the persistent presence of senescent cells in aged or chronically damaged tissues. Moreover, PDGF-A was induced very early upon senescence induction in cell culture, suggesting the time-dependent regulation of SASP factors might in part explain the beneficial versus deleterious effects of senescent cells. | [5] | Biology | train | 5 | news | http://www.sciencedaily.com/releases/2014/12/141211124526.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1073/pnas.1220333110 | Biology_easy_447 | The authors write: "In addition to conserving important species, maintaining ecosystem multifunctionality will require diverse landscape mosaics of diverse communities." | Thus, in addition to conserving important species, maintaining ecosystem multifunctionality will require diverse landscape mosaics of diverse communities. | "A mix of meadows, young forest, old forest and shrub lands, for example, might provide more benefits than a landscape of continuous young forest, even if that young forest itself has high biodiversity," Zavaleta said. The authors write: "In addition to conserving important species, maintaining ecosystem multifunctionality will require diverse landscape mosaics of diverse communities." "What's new here," Zavaleta says, "is reminding us that it's not just important to protect a diversity of species but also important to protect the mosaic of habitat patches in a landscape." | Higher β diversity also reduced the variability in multifunctionality. Thus, in addition to conserving important species, maintaining ecosystem multifunctionality will require diverse landscape mosaics of diverse communities. The effects of individual species (3-5) and α diversity (6) also become stronger as more functions are considered simultaneously (ecosystem multifunctionality). | [5] | Biology | train | 5 | news | http://www.sciencedaily.com/releases/2013/06/130607160335.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1038/s41556-018-0178-0 | Biology_easy_449 | "We showed that BAP1 inhibits tumor development partly through SLC7A11 and ferroptosis and that cancer-associated BAP1 mutants lose their abilities to repress SLC7A11 and to promote ferroptosis," said Gan. | Furthermore, we show that BAP1 inhibits tumour development partly through SLC7A11 and ferroptosis, and that cancer-associated BAP1 mutants lose their abilities to repress SLC7A11 and to promote ferroptosis. | They also discovered that BAP1 promotes ferroptosis by mediating repression of a cystine 'transporter' called SLC7A11. "We showed that BAP1 inhibits tumor development partly through SLC7A11 and ferroptosis and that cancer-associated BAP1 mutants lose their abilities to repress SLC7A11 and to promote ferroptosis," said Gan. "Together, our results uncover a previously unappreciated mechanism coupling ferroptosis to tumor suppression." | Here, integrated transcriptomic, epigenomic and cancer genomic analyses link BAP1 to metabolismrelated biological processes, and identify cystine transporter SLC7A11 as a key BAP1 target gene in human cancers. Furthermore, we show that BAP1 inhibits tumour development partly through SLC7A11 and ferroptosis, and that cancer-associated BAP1 mutants lose their abilities to repress SLC7A11 and to promote ferroptosis. Together, our results uncover a previously unappreciated epigenetic mechanism coupling ferroptosis to tumour suppression. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=37064060364&p=1pl&v=1&x=a2fTxH3Rplcv8Uzwlz6SoQ |
10.1038/s41467-018-05774-5 | Biology_easy_450 | The variation of the composition of the oxides allows tailoring the Li-storage properties of the active material. | The variation of the composition of the oxides allows tailoring the Li-storage properties of the active material. | In this study, to our knowledge for the first time, it is shown that high entropy oxides are very promising materials for reversible electrochemical energy storage. The variation of the composition of the oxides allows tailoring the Li-storage properties of the active material. The incorporation of different elements into HEO offers a modular approach for the systematic design of the electrode material. | In this study, to our knowledge for the first time, it is shown that high entropy oxides are very promising materials for reversible electrochemical energy storage. The variation of the composition of the oxides allows tailoring the Li-storage properties of the active material. The incorporation of different elements into HEO offers a modular approach for the systematic design of the electrode material. | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=37351463959&p=1pl&v=1&x=BzCmGEWEgoP1VMlqm7np_g |
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