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Context: The effect of levodopa (L-dopa), alone or in combination with a peripheral decarboxylase inhibitor (PDI), on plasma levels of aromatic-L-amino acid decarboxylase (ALAAD, = dopa decarboxylase), L-dopa, 3-O-methyl-dopa (3-OMD), dopamine (DA), noradrenaline, adrenaline and dopamine beta-hydroxylase has been studied. In healthy subjects and in patients with parkinsonism plasma ALAAD level fell after administration of L-dopa + benserazide, but returned to previous levels within 90 min. In a cross-sectional study blood was obtained, 2 h after dosing, from 104 patients with idiopathic parkinsonism, divided into four groups: no L-dopa treatment (group 1), L-dopa alone (group 2), L-dopa + benserazide (Madopar) (group 3) and L-dopa + carbidopa (Sinemet) (group 4). Plasma ALAAD, which was normal in groups 1 and 2, was increased 3-fold in groups 3 and 4, indicating that there was induction of ALAAD by the co-administration of PDI. Despite this induction of ALAAD, in groups 3 and 4, with half the daily L-dopa dose compared with group 2, plasma L-dopa and 3-OMD levels were 5 times higher, while plasma DA levels were not different. The DA/L-dopa ratio was decreased 5-fold in group 2 and 16-fold in groups 3 and 4 as compared with group 1. Neither 3-OMD levels nor 3-OMD/L-dopa ratios correlated with the occurrence of on-off fluctuations. In a longitudinal study of three patients started on Madopar treatment the induction of plasma ALAAD was found to occur gradually over 3-4 weeks. Further detailed pharmacokinetic studies in plasma and cerebrospinal fluid are required in order to elucidate whether the ALAAD induction by PDI may be related to the loss of clinical efficacy of combination therapy in some patients and how it is related to end-of-dose deterioration and on-off phenomena.
Question: Which drug is benserazide usually co-administered with? | [
"l-dopa"
] | task469-00d7bbdd08c44331a3763294e6021f7c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Most sedimentary rocks form from sediments. Sediments are small pieces of other rocks, like pebbles, sand, silt, and clay. Sedimentary rocks may include fossils. Fossils are materials left behind by once-living organisms. Fossils can be pieces of the organism, like bones. They can also be traces of the organism, like footprints. Most often, sediments settle out of water (Figure 4.13). For example, rivers carry lots of sediment. Where the water slows, it dumps these sediments along its banks, into lakes and the ocean. When sediments settle out of water, they form horizontal layers. A layer of sediment is deposited. Then the next layer is deposited on top of that layer. So each layer in a sedimentary rock is younger than the layer under it. It is older than the layer over it. Sediments are deposited in many different types of environments. Beaches and deserts collect large deposits of sand. Sediments also continuously wind up at the bottom of the ocean and in lakes, ponds, rivers, marshes, and swamps. Avalanches produce large piles of sediment. The environment where the sediments are deposited determines the type of sedimentary rock that can form. Sedimentary rocks form in two ways. Particles may be cemented together. Chemicals may precipitate. Over time, deposited sediments may harden into rock. First, the sediments are compacted. That is, they are squeezed together by the weight of sediments on top of them. Next, the sediments are cemented together. Minerals fill in the spaces between the loose sediment particles. These cementing minerals come from the water that moves through the sediments. These types of sedimentary rocks are called clastic rocks. Clastic rocks are rock fragments that are compacted and cemented together. Clastic sedimentary rocks are grouped by the size of the sediment they contain. Conglomerate and breccia are made of individual stones that have been cemented together. In conglomerate, the stones are rounded. In breccia, the stones are angular. Sandstone is made of sand-sized particles. Siltstone is made of smaller particles. Silt is smaller than sand but larger than clay. Shale has the smallest grain size. Shale is made mostly of clay-sized particles and hardened mud. Chemical sedimentary rocks form when crystals precipitate out from a liquid. The mineral halite, also called rock salt, forms this way. You can make halite! Leave a shallow dish of salt water out in the Sun. As the water evaporates, salt crystals form in the dish. There are other chemical sedimentary rocks, like gypsum. Table 4.1 shows some common types of sedimentary rocks and the types of sediments that make them up. Picture Rock Name Conglomerate Type of Sedimentary Rock Clastic Breccia Clastic Sandstone Clastic Siltstone Clastic Limestone Bioclastic Coal Organic Picture Rock Name Rock Salt Type of Sedimentary Rock Chemical precipitate
Question: When sediments settle out of water, they form | [
"horizontal layers."
] | task469-bfa6ab1fcb274b108c859481c4179e98 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Energy levels (also called electron shells) are fixed distances from the nucleus of an atom where electrons may be found. Electrons are tiny, negatively charged particles in an atom that move around the positive nucleus at the center. Energy levels are a little like the steps of a staircase. You can stand on one step or another but not in between the steps. The same goes for electrons. They can occupy one energy level or another but not the space between energy levels. The model in the Figure 1.1 shows the first four energy levels of an atom. Electrons in energy level I (also called energy level K) have the least amount of energy. As you go farther from the nucleus, electrons at higher levels have more energy, and their energy increases by a fixed, discrete amount. Electrons can jump from a lower to the next higher energy level if they absorb this amount of energy. Conversely, if electrons jump from a higher to a lower energy level, they give off energy, often in the form of light. This explains the fireworks pictured above. When the fireworks explode, electrons gain energy and jump to higher energy levels. When they jump back to their original energy levels, they release the energy as light. Different atoms have different arrangements of electrons, so they give off light of different colors. Q: In the atomic model Figure 1.1, where would you find electrons that have the most energy? A: Electrons with the most energy would be found in energy level IV. The smallest atoms are hydrogen atoms. They have just one electron orbiting the nucleus. That one electron is in the first energy level. Bigger atoms have more electrons. Electrons are always added to the lowest energy level first until it has the maximum number of electrons possible. Then electrons are added to the next higher energy level until that level is full, and so on. How many electrons can a given energy level hold? The maximum numbers of electrons possible for the first four energy levels are shown in the Figure 1.1. For example, energy level I can hold a maximum of two electrons, and energy level II can hold a maximum of eight electrons. The maximum number depends on the number of orbitals at a given energy level. An orbital is a volume of space within an atom where an electron is most likely to be found. As you can see by the images in the Figure 1.2, some orbitals are shaped like spheres (S orbitals) and some are shaped like dumbbells (P orbitals). There are other types of orbitals as well. Regardless of its shape, each orbital can hold a maximum of two electrons. Energy level I has just one orbital, so two electrons will fill this energy level. Energy level II has four orbitals, so it takes eight electrons to fill this energy level. Q: Energy level III can hold a maximum of 18 electrons. How many orbitals does this energy level have? A: At two electrons per orbital, this energy level must have nine orbitals. Electrons in the outermost energy level of an atom have a special significance. These electrons are called valence electrons, and they determine many of the properties of an atom. An atom is most stable if its outermost energy level contains as many electrons as it can hold. For example, helium has two electrons, both in the first energy level. This energy level can hold only two electrons, so heliums only energy level is full. This makes helium a very stable element. In other words, its atoms are unlikely to react with other atoms. Consider the elements fluorine and lithium, modeled in the Figure 1.3. Fluorine has seven of eight possible electrons in its outermost energy level, which is energy level II. It would be more stable if it had one more electron because this would fill its outermost energy level. Lithium, on the other hand, has just one of eight possible electrons in its outermost energy level (also energy level II). It would be more stable if it had one less electron because it would have a full outer energy level (now energy level I). Both fluorine and lithium are
Question: any atom is most stable when its outermost energy level contains | [
"as many electrons as it can hold."
] | task469-e139439b7cc34271a49d6d78ac789c62 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: On 15 December 2015, Andreze, Beaupreau, La Chapelle-du-Genet, Geste, Jallais, La Jubaudiere, Le Pin-en-Mauges, La Poiteviniere, Saint-Philbert-en-Mauges and Villedieu-la-Blouere merged becoming one commune called Beaupreau-en-Mauges.
Question: Which replaced the Villedieu-la-Blouere? | [
"beaupréau-en-mauges"
] | task469-fdcd76f9cb4746a3b58d91fb0d821eaa | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Set on the campus of a small New England college, the film focuses on the volatile relationship of a middle-aged couple: associate history professor George (Richard Burton) and his hard-drinking wife Martha (Elizabeth Taylor), the daughter of the college president.It's 2:00 a.m. on a Sunday morning, and they have returned from one of her father's gatherings. Martha announces she has invited a young couple--Nick (George Segal), a young, good-looking, newly appointed instructor, and his mousey wife Honey (Sandy Dennis)--to join them for late-night drinks. George is disturbed because she did so without consulting him first, prompting Martha to launch into the first of many loud and lengthy tirades during which she taunts and criticizes him. Knowing his wife is drunk and quite lewd, he asks her to behave herself when they arrive, and when the doorbell rings, he warns her to refrain from mentioning their child to their company.Overhearing Martha's crude retort as the door opens, Nick and Honey immediately feel ill at ease and quickly find themselves caught in the middle of a verbal war zone when their efforts to engage in small talk set off a volley of insults between their hosts. Martha begins to flirt lewdly with Nick while his meek wife tries to pretend she is unaware of what is happening.While Martha is showing Honey where the bathroom is, George tests Nick's verbal sparring skills, but the young man is no match for his host. Realizing he and his wife are becoming embroiled in the middle of marital warfare, he suggests they depart, but George cajoles him into staying.Upon returning to the living room alone, Honey innocently mentions to George she was unaware he and Martha had a son on the verge of celebrating his 16th birthday. Martha reappears in a new outfit--form-fitting slacks and a revealing blouse--and when her husband makes a snide remark about the ensemble, she begins to demean his abilities as a teacher, then escalates her seduction of Nick, complimenting him on the body he developed as both a quarterback and an intercollegiate state boxing champion while criticizing George's paunch. She informs their guests about a past incident when George refused to engage in a friendly outdoor boxing match with his father-in-law and Martha put on a pair of gloves and punched him in the jaw, knocking him into the bushes. As she relates the story, George aims a shotgun at the back of her head, causing Honey to scream. He pulls the trigger, which releases an umbrella, while he tells his wife she's dead.Honey again raises the subject of George and Martha's son, prompting the couple to engage in a conversation Martha quickly tries to end without success. To counterattack George's relentless comments about the boy, she tells their guests her husband is unsure the child is his own, although he most assuredly is. They argue about the color of the boy's eyes until George threatens to expose the truth about the boy. Furious, Martha accuses him of being a failure whose youthful, idealistic plans for the future slowly deteriorated as he came to realize he wasn't aggressive enough to follow in his father-in-law's footsteps, leaving her stuck with a flop. George cuts the diatribe short by spinning Honey around and mockingly singing, "Who's afraid of Virginia Woolf?", a joke the shrewed Martha had made herself during the party earlier that evening.Inebriated and on the verge of throwing up from George's spinning, Honey rushes from the room. Martha goes to the kitchen to make coffee, and George and Nick go outside. The younger man confesses he was attracted to Honey more for her family's money than passion, and married her only because she mistakenly believed she was pregnant. George describes his own marriage as one of never-ending accommodation and adjustment, then admits he considers Nick a threat. George also tells a story about a boy he grew up with. This boy had accidentally killed his mother. Years later, George claims the boy was driving with his father. He swerved to "miss a porcupine" in the road,
Question: Who does Martha taunt? | [
"george"
] | task469-a42523b1dee64462976acfe925fc9a53 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Panthers went into the fourth quarter with a 17-3 lead over the Chiefs but things changed when Cairo Santos kicked a field goal, and Eric Berry had a pick six. Santos makes another field goal, tying the game at 17. In the Panthers' last possession of the game, the ball was stripped out of Kelvin Benjamin's hands and Kansas City gets the ball back. Santos makes the game-winning field goal for the Chiefs, and the Panthers fall to 3-6.
Question: Which team came out on top? | [
"the chiefs"
] | task469-8bf55cc4e3b94bffb954ee69220030db | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In The Future, a beautiful astronomatrix named Barbarella (Jane Fonda) floats through the galaxy in her spaceship, the Alpha-7. Suddenly she receives an urgent call on her monitor from none other than the President of Earth (Claude Dauphin). He informs her that a young scientist named Durand-Durand went missing sometime during a mission to the North Star and is believed to have landed somewhere in the Tau Ceti star system. Not much is known about this region of space-- the President worries that Durand's invention, the positronic ray, may fall into the hands of a primitive culture; beings who might seek to use this technology as a weapon and launch an intergalactic war. Since the Earth, free of all conflict for centuries, lacks military and police personnel, the President tasks Barbarella with a mission to find the scientist. He teleports her some weapons and a device that will signal the presence of Durand-Durand. The latter has a "tonguebox" incorporated in its design which can translate any language.Barbarella spends most of the journey to Tau Ceti in suspended animation. She awakens just in time to lose control of her spacecraft and crash land on Planet 16, which her spaceship informs her contains an atmosphere similar to Earth's. She changes into a new outfit to explore the arctic terrain. The first humanoids she meets are a pair of twin girls-- they jabber to her excitedly in a language she can't understand. Before she can adjust her tonguebox, one of them knocks Barbarella unconscious with a piece of ice. The girls then pull the dazed explorer along in their sled, which is attached to a manta ray-like creature that glides across the ice.The girls arrive with Barbarella at the wreck of another craft where several other sets of twin children are sheltered and indigo-blue bunny rabbits abound. Barbarella recognizes the wreck as the Alpha-1, former spaceship of Durand-Durand. The children tie Barbarella to a post and bring out several mechanical dolls that walk towards her. It soon becomes apparent that the dolls all have sharp metal teeth and hinged jaws. They bite Barbarella while the children giggle gleefully, amused by their game.Suddenly a man appears with several armored guards. He cracks a whip and captures the children in a net, then unties Barbarella. Once she gets her tonguebox working, she's able to understand him when he explains that he is a Catchman named Mark Hand (Ugo Tognazzi) and that all children are sent away to the forests of Weir "until they've reached a serviceable age," at which point he captures them and brings them back to civilization. He offers Barbarella a ride back to her spaceship. When she asks how she can repay him, he tells her that he'd like to make love to her. Back on Earth, when people want to bond, erotically, they each take an exultation transference pill and press their palms against one another's. Barbarella is prepared to do this with the Catchman, but he's not interested in all that, he tells Barbarella that he wants to have sex on the bed in his snowship. She reluctantly agrees to do it the old-fashioned way, but soon discovers that she finds the experience quite enjoyable. The Catchman gives her a fur and repairs her spaceship, only when she tries to fly off, the ship's computer informs her that it's been repaired in reverse. She crashes back into the planet and quickly activates the ship's terra-screws so that she can tunnel through the planet's core.She surfaces in the Labyrinth, amongst strange creatures including an "ornithanthrope," or angel, named Pygar (John Phillip Law), who was blinded in the city of Sogo. Pygar takes Barbarella to visit Professor Ping (Marcel Marceau) who explains that Pygar is aerodynamically sound, but lacks the morale to fly. Pygar, Professor Ping and all of the other unfortunates who roam the Labyrinth were imprisoned there by order of the Great Tyrant. They are not evil enough to be allowed to live in Sogo, the City of Night. Pygar takes Barbarella to his nest where they have sex. This restores Pygar's will to fly and Barbarella
Question: What does Durand Durand use to decimate the rebels? | [
"positronic ray"
] | task469-9705fefe914e46de992f2aec9634f574 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The spin-off movie focuses on Matt Stifler (Tad Hilgenbrinck), the younger brother of Steve Stifler from the previous American Pie films. Matt is eager to enter the family business of making porno films, so he can prove to his older brother that he is "up to the standards of the Stifmeister." Stifler and his friends play a prank on the band students during the seniors' graduation ceremony by spraying pepper spray on the mouthpieces of the band's instruments. Matt narrowly escapes getting caught and stows the can of pepper spray in his front pocket, which subsequently leaks onto his genitals. The band members begin to play "Pomp and Circumstance", only to become too irritated by the pepper spray to continue. During the commotion, one of the students trips and pulls down the back curtain, which reveals Matt, who is washing his pepper-spray-soaked genitals in a drinking fountain, in front of the whole school.The band leader Elyse Houston (Arielle Kebbel) demands that Stifler be punished for ruining their performance, stating that he always gets away with his pranks because he is the school's star football player. The school's guidance counselor Chuck Sherman ("The Sherminator") (played by Chris Owen from the original American Pie films) decides that a worthwhile punishment would be for Stifler to attend band camp, in the hopes that he would make friends with the "bandies" and not follow in the footsteps of his much-hated brother.When first arriving, Matt is very disrespectful to the rules and also everyone at Tall Oaks and gets his band group in trouble. He is sent to the office of Noah Levenstein (Jim's father) (Eugene Levy), who works as the camp MACRO (Morale and Conflict Resolution Officer; he's filling in for Michelle as she is now pregnant), recommends that he try to fit in and earn the band's trust, which is the last thing that Matt wants to do. However, a phone call from a friend, who says that earning their trust will get him better footage for his video, inspires Matt to be much more respectful and humble towards the band.Matt finds out that his dorky roommate Ernie Kapolwitz (Jason Earles) has an extensive knowledge of spy cameras and technology, so Matt agrees to let him help with the filming, making his first friend at Tall Oaks. As Matt "is earning the band's trust" he gets into a big confrontation with their rival band leader, Brandon Van der Camp (Matt Barr), and even goes as far as to accept a duel challenge made by him, having no idea what a "duel" is.It turns out that a duel is the two performers showing off their music skills, with Brandon playing the snare drum, and Matt playing the triangle. Throughout the majority of the competition it seems that Brandon is the heavy favourite; during Brandon's second round of performing, Matt walks away humiliated. As Brandon is about to be declared the official winner, Matt comes back playing the bagpipes to the tune of 'Play That Funky Music' showing that he is actually a decent player, surprising everyone, including Elyse, who is pleasantly surprised by Matt's performance.As Matt is still recording the various happenings at the camp, he gradually becomes friends with some of the band members from his school. He gains some respect from Ernie after Matt sets him up on a date with tattooed bandmate Chloe (Crystle Lightning). Matt starts falling for Elyse, who is revealed to have been a friend of Matt's in 8th grade but had a falling out after Matt started hanging around with Steve and his friends and acting like The Stifmeister. Matt is eventually caught with his movies, and his once-friends want nothing more to do with him.After another talk with Jim's Dad, Matt comes to realize that his brother is not as great or cool as he once thought and that following in his footsteps is not a good idea, so he deletes all the videos he recorded at band camp. He even enlists the help of the band to help Elyse get the band scholarship that Stifler
Question: Who was disqualified for plagiarism? | [
"brandon"
] | task469-859f00f5140b4302bbb5ce828895029a | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Coming off their bye week, the Lions played a Week 5 Black and Blue Division duel at home with the Chicago Bears. In the first quarter, Detroit trailed early as Bears kicker Robbie Gould got a 37-yard field goal. In the second quarter, the Lions continued to trail as QB Kyle Orton completed a 9-yard TD pass to RB Matt Forte and a 12-yard TD pass to WR/KR Devin Hester. In the third quarter, Chicago continued its domination as Forte got a 1-yard TD run, and CB Charles Tillman returned an interception 26 yards for a touchdown. Afterwards, Detroit got its only score of the game as rookie RB Kevin Smith scored on a 12-yard TD run. In the fourth quarter, the Bears sealed the win when Gould nailed a 45-yard field goal.
Question: Who threw the only passing touchdown of the game? | [
"kyle orton"
] | task469-a213f6b2f7a646fe96c07ca4a5c0f50f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: To investigate the clinicopathologic features of focal cortical dysplasia (FCD) in patients with refractory epilepsy. The clinical, radiologic and pathologic features of 38 cases of FCD receiving surgical treatment in 2005 were reviewed retrospectively. The mean age of disease onset was 9.2 years. The disease lasted for 11.9 years on average and often presented as complex partial seizure. Radiologic examination revealed hippocampal sclerosis, or abnormal signals in the grey matter in 21 cases. According to Palmini's classification system, the following pathologic subgroups were identified: FCD type IA (3/38), FCD type IB (20/38), FCD type IIA (5/38) and FCD type IIB (5/38). The remaining 5 cases were classified as mild cortical dysplasia. Topographically, FCD type II was often seen in the extratemporal region (8/10), predominantly in the frontal lobe (5/8). Dual pathology was identified only in cases with FCD type IB. Immunohistochemical study showed that the giant neurons, immature neurons and dysmorphic neurons were strongly positive for NeuN. A small number of balloon cells expressed nestin. FCD is a common cause of refractory epilepsy. FCD type IB is the predominant pathologic subtype. Associated hippocampal sclerosis is sometimes seen. Clinicopathologic differences between FCD type I and FCD type II are observed.
Question: Which disorder is rated by Palmini classification? | [
"focal cortical dysplasia"
] | task469-a1c2e5338ac54be4935478c873c7e63b | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Wayne's World 2, while retaining Wayne Campbell, Garth Algar, and Wayne's girlfriend Cassandra Wong, has a much more serious tone and outcome than the first Wayne's World movie. The movie opens with Wayne explaining that the course of the 'past year,' in this case the year between the two movies, has seen a lot of changes in his life. Although he still hosts his television show Wayne's World, he now lives in an apartment building which was once a doll factory. He is very proud of the fact that Cassandra's carrer is taking off and they are still very involved with each other, but talks about how people are telling him he needs to find focus in his life and 'grow up.' In a dream, Wayne sees singer Jim Morrison, who tells Wayne to put on a music festival in Aurora, Illinois. The festival itself makes Wayne go through the process of booking bands and getting permits for the event, although the event itself isn't truly the core to the story. The festival takes a back seat to Wayne's romance with Cassandra, who he comes to acknowledge he truly loves and wonders about their future together. Wayne, about half way through the film, has to prove himself to Mister Wong, Cassandra's father. In a satire of classic Kung Fu movies, Wayne and Mister Wong battle each other while dubbing themselves. Wayne proves himself to be a worthy warrior, but does not earn the complete respect of Mister Wong. Cassandra's carrer now centers around her producer, Bobby Kahn, played by actor Christpher Walken. Wayne is suspiscious of Cassandra and Bobby's relationship together, as it becomes obvious to Wayne that it sees that where ever Cassandra is Bobby is also. Wayne spies on Cassandra and later confronts her about what he witnessed, causing her to punch him in the face and seeminly ending their relationship. Wayne struggles with this throughout the rest of the movie, wanting to make peace with Cassandra and win her back. Wayne later discovers that Cassandra is about to be wed to Bobby, forcing Wayne to abandon his post on the day of his festival to stop the wedding and pronounce his love for Cassandra. At the very last minute, he interupts the wedding ceremony of Cassandra and Bobby, where he then discovers that Mister Wong had set up the wedding to gain his green card. Wayne and Cassandra then return to Wayne's music festival where she performs and Aerosmith arrives shortly thereafter. The movie ends immediately after the festival, leaving the viewer to believe that Wayne has finally 'grown up' into an 'adult' now that he has not only confirmed his love for Cassandra but managed to organize and run a music festival without forgetting what it means to 'have fun.' Garth becomes involved with a seemingly older woman in Wayne's World 2, who he later discovers is married and hisentiore relatinship with the woman was a sham to get back at her husband, who she wants dead. Garth's character hasn't seem to have grown or changed much from the first Wayne's World movie, however by the end of Wayne's World 2 it appears as if he has matured emotionally to where Wayne's character was at the end of the first Wayne's World movie, although his character and his problems never appear to have found resolution by the end of Wayne's World 2.
Question: What do Wayne Campbell and Garth Algar call their concert? | [
"music festival"
] | task469-01821e07710649ac8869cdfaa2fd9934 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Five teens from Sarasota, Florida, are making music from garbage. The Garbage-Men band's instruments are made from recycled objects. The guitars are boxes. A horn is made from pipes. The keyboard is formed from old bottles. The band started about two years ago. Jack Berry decided to make a playable, homemade guitar. After some trial-and-error, he ended up building it from a cereal box, a yardstick and toothpicks. After Jack showed his creation to his friend Ollie Gray, Ollie had the idea to form a band using other homemade instruments as a way to promote recycling. "We want to show people there is more to recycling than throwing things away in the bin ," Jack, 16, said, "You can actually reuse materials." Ollie, 15, plays drums made from trash cans. Evan Tucker, 15 (bass guitar); Harrison Paparatto, 15 (horns and violin); and Austin Siegel, 15, (keyboard), round out the band. The Garbage-Men plays at local events around Sarasota, including festivals, farmer's markets and community fundraisers. Typically, the teens will set up on the street and perform popular songs from the 1960s, including classic Beatles tunes and people's favorite "Wipe Out," by The Surfaris. In between sets, they talk about recycling the offer tips for how to help the environment. while they perform, Jack's little brother Trent, 11, gives out flyers about recycling and helps sell the band's CD and other merchandise. The band donates the money from sales to charity. They have raised more than $2,500 for Heifer International. The organization gives farm animals, seeds and agricultural training to people in poor countries to help end poverty and hunger. The band--all tenth graders--tries to play a gig for America's Got Talent. The teens hope to eventually take their show on the road by touring in other states. "Music is a really good way to get a good message across to people because it's really accessible," Jack says. Their instruments may be garbage, but their message isn't.
Question: Who first had the idea to organize the Garbage-Men band? | [
"ollie gray"
] | task469-f1e15bc5e07e45f693be19c8282c98ed | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Succession is now regulated by laws passed by the National Diet. The current law excludes women from the succession. A change to this law had been considered until Princess Kiko gave birth to a son. Until the birth of Prince Hisahito, son of Prince Akishino, on September 6, 2006, there was a potential succession problem, since Prince Akishino was the only male child to be born into the imperial family since 1965. Following the birth of Princess Aiko, there was public debate about amending the current Imperial Household Law to allow women to succeed to the throne. In January 2005, Prime Minister Junichiro Koizumi appointed a special panel composed of judges, university professors, and civil servants to study changes to the Imperial Household Law and to make recommendations to the government. The panel dealing with the succession issue recommended on October 25, 2005, amending the law to allow females of the male line of imperial descent to ascend the Japanese throne. On January 20, 2006, Prime Minister Junichiro Koizumi devoted part of his annual keynote speech to the controversy, pledging to submit a bill allowing women to ascend the throne to ensure that the succession continues in the future in a stable manner. Shortly after the announcement that Princess Kiko was pregnant with her third child, Koizumi suspended such plans. Her son, Prince Hisahito, is the third in line to the throne under the current law of succession. On January 3, 2007, Prime Minister Shinzo Abe announced that he would drop the proposal to alter the Imperial Household Law.
Question: Who was born first, Prince Hisahito or Prince Akishino? | [
"prince hisahito",
"prince akishino"
] | task469-65a5be4682b44e55b5c9f496293bccfc | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Internet will overtake radio in 2008 and become the world's fourth-largest advertising medium, a year earlier than forecast. Global spending on Internet advertising increased from 18.7 billion U.S. dollars in 2005 to 24.9 billion dollars last year, according to Zenith Optimedia, the media-buying agency. The Middle East and Asia are driving a boom in global advertising spending. Zenith predicted _ of 7.7% in spending in Asia in the run-up to the 2008 Olympic Games in Beijing. In the Middle East and Eastern Europe, advertising spending is growing faster than in North America and Western Europe, which are "maturing rapidly" as advertising markets, Zenith said. Advertising spending in the Middle East increased by 22.4% between 2005 and 2006, compared with growth of 5.2% in America and 4 per cent in Western Europe. Zenith attributed the huge percentage share in the Middle East to the growth in local economies and high oil prices. In addition to the Olympics, the U.S. presidential election and the European football championship in Austria and Switzerland next year will be the biggest contributors to overall growth during the next two years. However, Zenith noted, the market should brace itself for a fall in revenues after those big events end.
Question: Which has enjoyed the fastest growth of advertising spending in the last year? | [
"the middle east."
] | task469-2802d4f0400647299de35db1b9eeb3e3 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: School leaders from around the country gathered at the White House on November 19 for"Connected to the Future," a conference about digital technology in education.Connected is the Obama Government's five-year plan to support the growth of digital learning in schools.This growth includes equipping America's schools with high-speed broadband Internet . At the conference,President Barack Obama said the U.S.Department of Education is taking steps to help educators and school districts as they change to digital learning.The department created new guidelines to help schools work to improve their technological infrastructure .The guidelines are also designed to help schools choose the right digital devices and set up policies for their proper use. "We have to do more to offer our children a world-class education,"Obama told the crowd of school leaders."We have to improve our education level if we are going to make sure that every child in America can go as far as their dreams and talents will take them." According to Cecilia Muoz,director of the Domestic Policy Council,less than 40% of public schools in America have high-speed Internet access in their classrooms.She believes that Connected will make America a leader in using technology to educate students. Muoz mentioned the Mooresville school district as a success story.Mooresville provides each student in grades 3 through 12 with a device,and uses a mostly digital subject.Muoz said Mooresville now ranks third in test scores and second in graduation rates in the state. At the end of the president's speech,1,200 school leaders attending the event signed the Future Ready District Pledge on their iPads.It promises the education leaders to help develop a culture of learning through technology at their schools,and to support teachers and students in using technology. "Every child deserves a chance at a world-class education,"Obama added."That's what makes our nation great."
Question: Who will take charge of putting the plan into practice? | [
"the u.s.department of education."
] | task469-cac1f0859cdf436cb6a02afe6283711c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Eta Telescopii ( Tel, Telescopii), also known as HD 181296 or HR 7329, is a star in the southern constellation of Telescopium.
Question: What is the name of the constellation which Eta Telescopii belongs? | [
"telescopium"
] | task469-a049f2c7b98443b4b29409d1af0a9308 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Rob Larter graduated from the University of Birmingham with a PhD in Geological Sciences in 1991.
Question: What college did Rob Larter go to? | [
"university of birmingham"
] | task469-8f24ebc120164849ab40b8ec7d0cf7ba | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: A cell is the smallest structural and functional unit of an organism. Some organisms, like bacteria, consist of only one cell. Big organisms, like humans, consist of trillions of cells. Compare a human to a banana. On the outside, they look very different, but if you look close enough youll see that their cells are actually very similar. Most cells are so small that you cannot see them without the help of a microscope. It was not until 1665 that English scientist Robert Hooke invented a basic light microscope and observed cells for the first time, by looking at a piece of cork. You may use light microscopes in the classroom. You can use a light microscope to see cells ( Figure 1.1). But many structures in the cell are too small to see with a light microscope. So, what do you do if you want to see the tiny structures inside of cells? In the 1950s, scientists developed more powerful microscopes. A light microscope sends a beam of light through a specimen, or the object you are studying. A more powerful microscope, called an electron microscope, passes a beam of electrons through the specimen. Sending electrons through a cell allows us to see its smallest parts, even the parts inside the cell ( Figure 1.2). Without electron microscopes, we would not know what the inside of a cell looked like. The outline of onion cells are visible under a light microscope. In 1858, after using microscopes much better than Hookes first microscope, Rudolf Virchow developed the hypoth- esis that cells only come from other cells. For example, bacteria, which are single-celled organisms, divide in half (after they grow some) to make new bacteria. In the same way, your body makes new cells by dividing the cells you already have. In all cases, cells only come from cells that have existed before. This idea led to the development of one of the most important theories in biology, the cell theory. Cell theory states that: 1. All organisms are composed of cells. 2. Cells are alive and the basic living units of organization in all organisms. 3. All cells come from other cells. As with other scientific theories, many hundreds, if not thousands, of experiments support the cell theory. Since Virchow created the theory, no evidence has ever been identified to contradict it. Although cells share many of the same features and structures, they also can be very different ( Figure 1.3). Each cell in your body is designed for a specific task. In other words, the cells function is partly based on the cells structure. For example: Red blood cells are shaped with a pocket that traps oxygen and brings it to other body cells. Nerve cells are long and stringy in order to form a line of communication with other nerve cells, like a wire. Because of this shape, they can quickly send signals, such as the feeling of touching a hot stove, to your brain. Skin cells are flat and fit tightly together to protect your body. As you can see, cells are shaped in ways that help them do their jobs. Multicellular (many-celled) organisms have many types of specialized cells in their bodies. Red blood cells (left) are specialized to carry oxygen in the blood. Neurons (cen- ter ) are shaped to conduct electrical im- pulses to many other nerve cells. These epidermal cells (right) make up the skin of plants. Note how the cells fit tightly together. While cells are the basic units of an organism, groups of cells can perform a job together. These cells are called specialized because they have a special job. Specialized cells can be organized into tissues. For example, your liver cells are organized into liver tissue. Your liver tissue is further organized into an organ, your liver. Organs are formed from two or more specialized tissues working together to perform a job. All organs, from your heart to your liver, are made up of an organized group of tissues. These organs are part of a larger system, the organ systems. For example, your brain works
Question: who developed the idea that all cells come from other cells? | [
"rudolf virchow"
] | task469-05e8a6fb951f42f2b8807bc44ff9627d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Over the next year, however, the Polish forces were subject to attrition, as the Sejm again refused to raise taxes and pay the army, resulting in mass desertions of unpaid soldiery. The Polish problems were further aggravated by the incompetent leadership of hetman Micha Kazimierz Pac, who obstructed Sobieski's leadership, while the Ottomans continued to receive reinforcements. Nonetheless in 1674 the Commonwealth resumed the offensive, taking advantage of a new Muscovy-Ottoman conflict that year, and the Polish-Ottoman war remained undecided.:275 Sobieski's force of 6,000 defeated 20,000 Turks and Tatars under Ibrahim Shyshman in the battle of Lwow in August 1675.:653 Even after the Battle of Trembowla, the Sejm still refused his pleas for more funds and a larger army.:653 In 1676, after Sobieski's 16,000 withstood the two-week siege of Zurawno, by 100,000 men under Ibrahim Pasha, a new peace treaty was signed, the Treaty of Zurawno.:655 The peace treaty partially reversing those from Buczacz: the Ottomans kept approximately two thirds of the territories they gained in 1672, and the Commonwealth no longer was obliged to pay any kind of tribute to the Empire; a large number of Polish prisoners were released by the Ottomans.
Question: Which happened first, the siege of A"urawno or the Treaty of A"urawno? | [
"siege of żurawno"
] | task469-2090986c0d194da3bed5da05a2bc15b0 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Wavelength is one way of measuring the size of waves. It is the distance between two corresponding points on adjacent waves, and it is usually measured in meters. How it is measured is a little different for transverse and longitudinal waves. In a transverse wave, particles of the medium vibrate up and down at right angles to the direction that the wave travels. The wavelength of a transverse wave can be measured as the distance between two adjacent crests, or high points, as shown in the Figure 1.1. In a longitudinal wave, particles of matter vibrate back and forth in the same direction that the wave travels. The wavelength of a longitudinal wave can be measured as the distance between two adjacent compressions, as shown in the Figure 1.2. Compressions are the places where particles of the medium crowd close together as the energy of the wave passes through. The wavelength of a wave is related to the waves energy. Short-wavelength waves have more energy than long- wavelength waves of the same amplitude. (Amplitude is a measure of how far particles of the medium move up and down or back and forth when a wave passes through them.) You can see examples of transverse waves with shorter and longer wavelengths in the Figure 1.3. A: Violet light has the greatest energy because it has the shortest wavelength.
Question: which color of visible light has the most energy? | [
"violet"
] | task469-c2fa26c73d7b41c78ced555a28db0861 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Hoping to break their current losing streak the Cardinals flew to Arrowhead Stadium for an interconference duel with the Chiefs. The Cardinals scored with kicker Jay Feely hitting a 36-yard field goal, but they fell behind with QB Matt Cassel completing a 1-yard TD pass to WR Dwayne Bowe. This was followed by RB Thomas Jones getting a 1 and a 3-yard TD run. The Cardinals responded with Feely making a 29-yard field goal, but they struggled further with kicker Ryan Succop getting a 23-yard field goal, followed by Cassel throwing a 38-yard TD pass to Bowe. The Cardinals cut the lead with QB Derek Anderson completing a 3-yard TD pass to WR Larry Fitzgerald.
Question: How many yards was the longest field goal? | [
"36-yard"
] | task469-45e8bfa1e8ec4f4f9a2c8c049b8a6ae5 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Lecudina tuzetae is a parasitic protozoan (Gregarine, Apicomplexa) living in the intestine of a marine polychaete annelid, Nereis diversicolor. Using electron and fluorescence microscopy, we have characterized the dynamic changes in microtubule organization during the sexual phase of the life cycle. The gametocyst excreted from the host worm into seawater consists of two (one male and one female) gamonts in which cortical microtubule arrays are discernible. Each gamont undergoes multiple nuclear divisions without cytokinesis, resulting in the formation of large multinucleate haploid cells. After cellularization, approximately 1000 individual gametes are produced from each gamont within 24 h. Female gametes are spherical and contain interphase cytoplasmic microtubule arrays emanating from a gamma-tubulin-containing site. In male gametes, both interphase microtubules and a flagellum with "6 + 0" axonemal microtubules extend from the same microtubule-organizing site. At the beginning of spore formation, each zygote secretes a wall to form a sporocyst. Following meiotic and mitotic divisions, each sporocyst gives rise to eight haploid cells that ultimately differentiate into sporozoites. The ovoid shaped sporocyst is asymmetric and forms at least two distinctive microtubule arrays: spindle microtubules and microtubule bundles originating from the protruding apical end corresponding to the dehiscence pole of the sporocyst. Because antibodies raised against mammalian centrosome components, such as gamma-tubulin, pericentrin, Cep135, and mitosis-specific phosphoproteins, react strongly with the microtubule-nucleating sites of Lecudina, this protozoan is likely to share common centrosomal antigens with higher eukaryotes.
Question: Where in the cell do we find the protein Cep135? | [
"centrosome"
] | task469-df70277ccf7f442c8d585b6688ec2a63 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: To describe your location wherever you are on Earths surface, you could use a coordinate system. For example, you could say that you are at 1234 Main Street, Springfield, Ohio. Or you could use a point of reference. If you want to meet up with a friend, you could tell him the distance and direction you are from the reference point. An example is, I am at the corner of Maple Street and Main Street, about two blocks north of your apartment. When studying Earths surface, scientists must be able to pinpoint a feature they are interested in. Scientists and others have a system to describe the location of any feature. Usually they use latitude and longitude as a coordinate system. Lines of latitude and longitude form a grid. The grid is centered on a reference point. You will learn about this type of grid when we discuss maps later in this chapter. When an object is moving, it is not enough to describe its location. We also need to know direction. Direction is important for describing moving objects. For example, a wind blows a storm over your school. Where is that storm coming from? Where is it going? The most common way to describe direction is by using a compass. A compass is a device with a floating needle (Figure 2.1). The needle is a small magnet that aligns itself with the Earths magnetic field. The compass needle always points to magnetic north. If you have a compass and you find north, you can then know any other direction. See the directions, such as east, south, west, etc., on a compass rose. A compass needle lines up with Earths magnetic north pole. This is different from Earths geographic north pole, or true north. The geographic north pole is the top of the imaginary axis around which Earth rotates. The geographic north pole is much like the spindle of a spinning top. The location of the geographic north pole does not change. However, the magnetic north pole shifts in location over time. Depending on where you live, you can correct for the difference between the two poles when you use a map and a compass (Figure 2.2). Some maps have a double compass rose. This allows users to make the corrections between magnetic north and true north. An example is a nautical chart that boaters use to chart their positions at sea (Figure 2.3). As you know, the surface of Earth is not flat. Some places are high and some places are low. For example, mountain ranges like the Sierra Nevada in California or the Andes in South America are high above the surrounding areas. We can describe the topography of a region by measuring the height or depth of that feature relative to sea level (Figure mountains, while others are more like small hills! Relief, or terrain, includes all the landforms of a region. A topographic map shows the height, or elevation, of features in an area. This includes mountains, craters, valleys, and rivers. For example, Figure 2.5 shows the San Francisco Peaks in northern Arizona. Features on the map include mountains, hills and lava flows. You can recognize these features from the differences in elevation. We will talk about some different landforms in the next section. If you take away the water in the oceans (Figure 2.6), Earth looks really different. You see that the surface has two main features: continents and ocean basins. Continents are large land areas. Ocean basins extend from the edges of continents to the ocean floor and into deep trenches. Continents are much older than ocean basins. Some rocks on the continents are billions of years old. Ocean basins are only millions of years old at their oldest. Because the continents are so old, a lot has happened to them! As we view the land around us we see landforms. Landforms are physical features on Earths surface. Landforms are introduced in this section but will be discussed more in later chapters. Constructive forces cause landforms to grow. Lava flowing into the ocean can build land outward. A volcano can be a constructive force. Destructive forces may blow landforms
Question: device with a magnetic needle that is used to find the magnetic north pole | [
"compass"
] | task469-0cabb73bdda3453f805d7933a2f95855 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Women-initiated HIV-prevention products are urgently needed. To address this need, a trial was conducted to assess the safety and pharmacokinetics of a silicone elastomer matrix vaginal ring containing 25 mg of the antiretroviral drug dapivirine when used continuously for 28 consecutive days. A double-blind, randomized, placebo-controlled trial was conducted in 16 healthy, HIV-negative women, 18-40 years of age, who were randomized 1:1 to use either the active or matching placebo ring for 28 days. Participants were followed during and for 28 days after ring use for safety and pharmacokinetic evaluations. The dapivirine vaginal ring was safe and well tolerated with no differences in safety endpoints between the active and placebo ring. The concentration-time plots of dapivirine in vaginal fluid were indicative of a sustained release of dapivirine over the 28 days of use. Dapivirine vaginal fluid concentrations were highest near the ring, followed by the cervix and introitus (mean Cmax of 80, 67 and 31 g/g, respectively). Vaginal fluid concentrations of dapivirine on the day of ring removal (day 28) at all three collection sites exceeded by more than 3900-fold the IC99 for dapivirine in a tissue explant infection model. Plasma dapivirine concentrations were low (< 1 ng/ml) and remained well below those observed at the maximum tolerated dose for oral treatment (mean Cmax of 2286 ng/ml). The dapivirine vaginal ring has a safety and pharmacokinetic profile that supports its use as a sustained-release topical microbicide for HIV-1 prevention in women.
Question: Which infection can be prevented with Dapivirine? | [
"hiv"
] | task469-c4ef293e21b744949ba97a84b799a5c8 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Coming off their home win over the Rams, the Bengals flew to Bill Walsh Field at Monster Park for a Saturday night interconference duel with the San Francisco 49ers. After a scoreless first quarter, Cincinnati trailed early in the second quarter as 49ers QB Shaun Hill got a 3-yard TD run. Afterwards, the Bengals would take the lead as kicker Shayne Graham managed to get a 24-yard field goal, while QB Carson Palmer completed a 52-yard TD pass to WR Chris Henry. San Francisco would end the half with Hill completing a 17-yard TD pass to TE Vernon Davis. In the third quarter, the 49ers increased their lead with kicker Joe Nedney getting a 29-yard and a 38-yard field goal. In the fourth quarter, Cincinnati tried to respond as Graham kicked a 35-yard field goal. However, the 49ers' defense held on for the win. With the loss, the Bengals fell to 5-9, securing Head Coach Marvin Lewis' first losing season with Cincinnati.
Question: What was the longest scoring play of the game? | [
"52-yard td pass"
] | task469-5e5cfc159cc843899eb9f526e6f4c159 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The 49ers would trail 20-13 with less than a minute to go. Blaine Gabbert would run in a game-tying 44 yard touchdown to tie the game at 20. The Bears appeared to have the game won when they went down the field after a decent kick return by Deonte Thompson for 74 yards. Robbie Gould came out to attempt a game-winning 36 yard field goal, but the kick was wide left, resulting in overtime. In the overtime period, Gabbert would throw the game-winning 71-yard touchdown pass to Torrey Smith to win the game for San Francisco. This was San Francisco's first win in Chicago since the 1989 NFC Championship Game.
Question: Which team won the game? | [
"san francisco"
] | task469-8ca9ad163a214040a03be03fc936d633 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Penguin Group Ordinary People Change The World! Penguin Group and TFK have partnered together to help teachers show their students how they can make the world a better place. Building the encouraging lives of historic figures including Amelia Earhart, Rosa Parks, Abraham Lincoln and Albert Einstein, this attractive program takes a look at the real life stories of ordinary young people who grew up to become extraordinary adults! Download the classroom poster, student worksheets and teacher's guide provided below. Classroom Poster : You can be a Hero, too. Classroom Poster Teachers Guide : Ordinary People Series Teacher's Guide Student Worksheet : Who's Your Hero? Worksheet Student Worksheet : Hero Matchup Worksheet PGA Junior League Golf It Takes a Team! TIME For Kids and PGA Junior League Golf have developed a program all about using teamwork to reach goals. Download this poster to get your students involved in the power and fun of teamwork and cooperation. Encourage your class to go to timeforkids.com/teampoll and take the poll! Classroom Poster : It Takes a Team! International Fund for Animal Welfare(IFAW) Cats, Dogs, & Us TIME for Kids has partnered with IFAW to present an educational animal awareness program called Cats, Dogs, & Us. This project is sure to attract and engage students with discussion starters, in-class activity ideas, a video viewing guide, and many other in-depth and fun resources. Preview IFAW's Cats, Dogs, & Us video at [Link] Classroom Poster : Cats, Dogs, & Us Classroom Poster Classroom Poster / Teachers Guide : Cats, Dogs, & Us Teachers Guide Full View Teachers Guide : Cats, Dogs, & Us Teachers Guide Pages Special Olympics Special Olympics Project UNIFY(r) in TIME and Special Olympics have teamed up to promote understanding of people's differences in the classroom, school and community. Special Olympics Project UNIFY(r) is an education-based project that uses sports and education programs to activate young people to develop communities where all youth are agents of change-promoting respect, dignity and support for people with mental disabilities. TFK Extra : in TIME Project UNIFY(r) Student Guide Teachers Guide : in TIME Project UNIFY(r) Teachers Guide
Question: Who are the materials mainly intended for? | [
"teachers."
] | task469-3a1f49b2197c41499323e966b1e64275 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Manhunters appear in DC Universe Online, voiced by David Jennison.
Question: What is the fictional universe that Manhunters belong to? | [
"dc universe"
] | task469-f97f9809828d45918225f7edca92d569 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Between 1952 and 1989 the university was named Bolesaw Bierut University of Wrocaw (Polish: Uniwersytet Wrocawski im. Bolesawa Bieruta) after Bolesaw Bierut, President of the Republic of Poland (1947--52).
Question: Whom is University of Wrocaw named after? | [
"bolesław bierut"
] | task469-6ac2c8c558454e5db4d2959ea738bcf1 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The military aspect of the war began with the Armistice of Mudros. The military operations of the Greco-Turkish war can be roughly divided into three main phases: the first phase, spanning the period from May 1919 to October 1920, encompassed the Greek Landings in Asia Minor and their consolidation along the Aegean Coast. The second phase lasted from October 1920 to August 1921, and was characterised by Greek offensive operations. The third and final phase lasted until August 1922, when the strategic initiative was held by the Turkish Army.
Question: What was the shortest phase of the war? | [
"the second phase"
] | task469-0bd614fa52874407bd86c9faa69c083d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: A dash of style with loads of attitude and a hunger to reach the stars, Lafangey Parindey is about a group of youngsters living in the backstreets of Mumbai. It is an unusual love story of Nandu (Neil Nitin Mukesh) and Pinky (Deepika Padukone) whose path to love is paved by friendship, grit and hope.He is wild. He is born to fight. He is One-Shot Nandu. For the raw, champion street fighter, one-shot is literally what it takes. Absolutely wild, fierce, and hungry to win, this fighter takes boxing to a new level by knocking down his opponents BLINDFOLDED. Needless to say, One-Shot lives life on his own terms and is a local hero amongst his friends. But all that soon changes, when he meets Pinky Palkar.She is blind. She is born to fly. She is Pinky Palkar. A unique girl, a powerhouse of talent! On one hand she works at a regular, boring 9-to-5 job at a mall but on the other hand, she is a kickass dancer on skates! Strong headed, talented and fiercely ambitious these traits make up Pinky Palkar's deadly personality. Her life's ambition is only one to rise above all the 'losers' living in her locality and carve a niche for herself. She will use her talent to show the others that she can win in life. There is only one, tiny, obstacle She is blind.Lafangey Parindey. Two different personalities. Two different lives. Destined to meet.Set in the grungy streets of Mumbai, Lafangey Parindey is an unusual, edgy love story about the never say die spirit even when your last chip is down. It is an intriguing journey of a blindfolded street fighter and a blind dancer who, along with four friends, set out to achieve the impossible.Born wild, will one-shot Nandu ever learn to love? Born to fly, will Pinky Palkar ever learn to see?
Question: Who plays One-Shot-Nandu? | [
"neil nitin mukesh"
] | task469-4ed258e0994549f88fc8b2188f16b091 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Newspaper columnist John Klein (Richard Gere) and his wife Mary (Debra Messing) are involved in an accident when Mary swerves to avoid a black, flying figure. John survives the crash unscathed, but Mary is hospitalized. After Mary dies of an unrelated brain tumor, John discovers mysterious drawings of the creature that she had created prior to the night of the accident. Two years later, John becomes lost in West Virginia and inexplicably finds himself in Point Pleasant, hundreds of miles off his route. Driving in the middle of the night, his car breaks down; and he walks to a nearby house to get help. The owner, Gordon Smallwood (Will Patton), reacts violently to John's appearance and holds him at gunpoint. Local police officer Connie Mills (Laura Linney) defuses the situation while Gordon explains that this is the third consecutive night John has knocked on his door asking to use a phone, much to John's confusion. John stays at a local motel and considers how he ended up so far from his original destination. Officer Mills mentions to John that many strange things have been occurring in the past few weeks and that people report seeing a large winged creature like a giant moth with red eyes. She also tells John about a strange dream she had, in which the words "Wake up, Number 37" were spoken to her. While conversing with Gordon one day, it is revealed to John that he had heard voices from his sink telling him that, in Denver, "99 will die". While discussing the day's events at a local diner, John notices that the news is showing a story on an airplane crash in Denver that killed all 99 passengers aboard. The next night, Gordon frantically explains that he had met the voices in his head, a being named Indrid Cold Later that night, Gordon calls John and says that he is standing with a character named Indrid Cold. While John keeps Cold on the line, Officer Mills checks on Gordon. Cold answers John's questions, convincing him that he is a supernatural being. This episode starts a string of supernatural calls to John's motel room. One tells him that there will be a great tragedy on the Ohio River. Later, John receives a call from Gordon and rushes to his home to check on him. He finds Gordon outside, dead from exposure. John becomes obsessed with the being, dubbed Mothman. He meets an expert on the subject, Alexander Leek (Alan Bates), who explains its nature and discourages John from becoming further involved. However, when John learns the governor (Murphy Dunne) plans to tour a chemical plant located on the Ohio River the following day, he becomes convinced the tragedy will occur there. Officer Mills and the governor ignore his warnings, and nothing happens during the tour. Soon afterwards, John receives a mysterious message that instructs him to await a call from his deceased wife Mary back in Georgetown, and he returns home. On Christmas Eve, Officer Mills calls and convinces him to ignore the phone call from "Mary", return to Point Pleasant, and join her. Though anguished, John agrees. As John reaches the Silver Bridge, a malfunctioning traffic light causes traffic congestion. As John walks onto the bridge to investigate, the bolts and supports of the bridge strain. The bridge comes apart, and John realizes that the prophesied tragedy on the Ohio River was about the bridge. As the bridge collapses, Officer Mills's car falls into the water. John jumps in after her and pulls her from the river and up to safety. As the two sit on the back of an ambulance, they see that 36 people have been killed, making Connie the "number 37" from her dream. The epilogue displays a series of graphics that state the cause of the bridge collapse was never fully determined. It also states that, although the Mothman has been sighted in other parts of the world, it was never seen again in Point Pleasant.
Question: What does Mary die of? | [
"of an unrelated brain tumor"
] | task469-a720f59d88334ab8b0234d1c00157eb2 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: As of the census of 2000, there were 445,342 people, 169,162 households, and 114,015 families residing in the county. The population density was 615 people per square mile (238/km). There were 178,913 housing units at an average density of 247 per square mile (95/km). The racial makeup of the county was 82.19% Race (United States Census), 1.15% Race (United States Census) or Race (United States Census), 0.65% Race (United States Census), 6.68% Race (United States Census), 0.30% Race (United States Census), 5.86% from Race (United States Census), and 3.17% from two or more races. 11.17% of the population were Race (United States Census) or Race (United States Census) of any race. 17.2% were of German American, 9.9% English American, 8.2% Irish American, and 6.7% Americans ancestry. 81.7% spoke only English at home, while 9.6% spoke Spanish and 1.2% Vietnamese.
Question: Did more people consider themselves of English ancestry or Irish ancestry? | [
"9.9% english american,",
"english"
] | task469-a7259c66bd844f12ae8152b175fe73a2 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Coming off their win over the Browns, the Bears stayed at home for a Week 9 duel with the Arizona Cardinals. Chicago would trail early in the first quarter as Cardinals quarterback Kurt Warner hooked up with wide receiver Larry Fitzgerald on an 11-yard touchdown pass. The Bears would answer as quarterback Jay Cutler competed a 33-yard touchdown pass to tight end Greg Olsen, but Arizona came right back as Warner hooked up with tight end Ben Patrick on a 6-yard touchdown pass. Chicago would find themselves in a huge deficit in the second quarter as Warner completed a 17-yard touchdown pass to Fitzpatrick and a 15-yard touchdown pass to tight end Anthony Becht, followed by kicker Neil Rackers nailing a 43-yard field goal. The Cardinals would add onto their lead as Rackers booted a 30-yard field goal in the third quarter. The Bears tried to rally in the fourth quarter as Cutler connected with Olsen on a 3-yard and a 20-yard touchdown pass, but Arizona pulled away with Warner completing a 4-yard touchdown pass to wide receiver Steve Breaston.
Question: Who threw the longest touchdown pass? | [
"jay cutler"
] | task469-5f3e1eeea30248c5946b627017b1d114 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: As of the 2010 United States Census, there were 1,951,269 people, 715,365 households, and 467,916 families residing in the county. The population density was . There were 840,343 housing units at an average density of . The racial makeup of the county was 60.9% white, 10.5% black or African American, 8.7% Asian, 0.7% Pacific islander, 0.7% American Indian, 13.5% from other races, and 5.1% from two or more races. Those of Hispanic or Latino origin made up 29.1% of the population. In terms of ancestry, 11.7% were Germans, 9.1% were Irish people, 7.6% were English people, 6.3% were Italians, and 2.7% were Americans.
Question: Which ancestry group made up most of the population? | [
"germans"
] | task469-e73bb62fa6c84b0c84212e8d72751ef3 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Facioscapulohumeral Disease (FSHD) is a dominantly inherited progressive myopathy associated with aberrant production of the transcription factor, Double Homeobox Protein 4 (DUX4). The expression of DUX4 depends on an open chromatin conformation of the D4Z4 macrosatellite array and a specific haplotype on chromosome 4. Even when these requirements are met, DUX4 transcripts and protein are only detectable in a subset of cells indicating that additional constraints govern DUX4 production. Since the direction of transcription, along with the production of non-coding antisense transcripts is an important regulatory feature of other macrosatellite repeats, we developed constructs that contain the non-coding region of a single D4Z4 unit flanked by genes that report transcriptional activity in the sense and antisense directions. We found that D4Z4 contains two promoters that initiate sense and antisense transcription within the array, and that antisense transcription predominates. Transcriptional start sites for the antisense transcripts, as well as D4Z4 regions that regulate the balance of sense and antisense transcripts were identified. We show that the choice of transcriptional direction is reversible but not mutually exclusive, since sense and antisense reporter activity was often present in the same cell and simultaneously upregulated during myotube formation. Similarly, levels of endogenous sense and antisense D4Z4 transcripts were upregulated in FSHD myotubes. These studies offer insight into the autonomous distribution of muscle weakness that is characteristic of FSHD.
Question: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4? | [
"fshd",
"facioscapulohumeral dystrophy"
] | task469-9f0112e93c004239be18f18ad19b3568 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In 2000, the label moved from Brussels to London and was renamed PIAS Recordings.
Question: What city is the band PIAS Recordings from? | [
"brussels"
] | task469-4e652bc236d14516a8ffd67347b7d29a | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: "People are ruder today because they are rushed and more 'time poor' than ever before, " says Patsy Rowe, " Manners have fallen off the radar . " Due to our strong attraction to electronic equipment it is a wonder more people don't wake up each morning and greet the singing birds with a complaint about the noise. Here are some examples of rudeness. Some people prefer to do almost everything over the internet. To them, dealing with an actual human is like an evolutionary step backward. It feels very slow because humans don, t work at 4G speeds. When you have dinner with friends, you will often notice someone paying more attention to his mobile phone. We have programmed ourselves to think that every new message brings life-changing news, so taking calls and checking our texts are more important than talking to the people we are with. What is worse, some people even tend to send anonymous rude messages by email. However, rudeness is never acceptable, Don, t assume it is OK to be rude if the person you, re in touch with won, t recognize you. If you have something awful to say, have the courage to face the person and say it, write a letter or email and sign it, or forget it. Upsetting people with unsigned messages is cruel and disgusting. We shouldn't blame technology for our shortcomings. Technology is here to help us, but we should not allow it to take over our lives. An important step is acknowledging our shortcomings. People spend a lot of time pointing out bad manners but it would be even more help if we'd publicly acknowledge good manners when we see them.
Question: The author thinks sending unsigned awful messages is | [
"disgusting"
] | task469-2f096786da964902bfe3f83214817a8d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The film opens in the middle of the night as the Sherwood robbers run through the forest. The robbers run through Nottingham and put their horses into a stable. Lady Marion (Cate Blanchett), wife of Sir Robert Loxley, rouses her servants and demands that they open the gates. Taking an arrow and setting it aflame, she shoots it at the feet of one of the robbers and tells them that she can see them. After they leave, she realizes that the seeds and grain of Nottingham were stolen and that they won't have anything to plant come spring.Robin Longstride (Russell Crowe) leads his men through the forest back to their own camp. When he fought in the Crusades, Robin was only an archer. As English troops lead an assault on a French stronghold, Robin and his men fight valiantly alongside King Richard the Lionheart (Danny Huston). A young archer attempts to plant a bomb bag on the portcullis but gets stuck. Robin races to him and rescues him before the French can kill him. Robin then retreats to safety before igniting the gate. The English troops attack the breach.Back in England, Richard's younger brother, Prince John (Oscar Isaac), is cheating on his wife Isabel (Jessica Raine) with Isabella (Lea Seydoux), the niece of the French king. John's mother Eleanor of Aquitaine (Eileen Atkins) walks in, passing his wife, who is standing sadly outside the room. John asks his mother to leave but she tells him that his behavior has given the king of France the excuse he needs to invade. She tells him to go to his wife, but he responds that his wife is barren. John expresses his desire to divorce his wife and marry the French girl since he anticipates becoming king upon Richard's death.Robin sets up a memory game where he hides a pea under three cups. Most people fall for it, but Little John (Kevin Durand) is determined to beat the game. When Robin offers three choices, Little John accuses him of hiding the pea in his hand while turning all of the cups. However, removing all three cups reveals that the pea was in the center cup all the time. Little John attacks Robin and they fight it out until they're interrupted by the king's arrival. When the king asks who started the fight, Robin says that it was his fault. The king talks to Robin and asks if he is honest enough to tell him his thoughts on the Crusade. The king wonders whether God would be pleased; Robin says no. The slaughter of the Muslims in their last battle made Robin feel that God did not approve of their actions and that they had acted like barbarians. Robin and his men are put in the stocks and Robin swears that he is done fighting and will return home once released.In nearby woods, Sir Godfrey (Mark Strong) visits King Philip (Jonathan Zaccai) of France. Philip notes that Sir Godfrey is of French and English heritage and asks where his allegiance lies. Godfrey pledges his allegiance to King Philip and Philip requests that Godfrey kill King Richard the Lionheart so that Philip may attack England under the leadership of the inept John. Sir Godfrey agrees.Meanwhile, King Richard leads his men in battle with the French. Upon breaching the perimeter, an archer shoots King Richard through the neck. As he dies, his men call for a doctor but can only comfort his passing with wine. His knights gather the crown and prepare to depart for the boats back to England. The young man Robin saved sees the incident and runs back to the stocks to free Robin and his friends. They grab their equipment and flee the camp as quickly as possible.Sir Robert Loxley (Douglas Hodge) is leading the knights of King Richard through the forest when Sir Godfrey's men attack and kill most of the knights. Loxley is skewered by a spear and left to die slowly. Godfrey asks about King Richard and is surprised to hear that the king was killed in battle. Loxley tells them that the king's crown is in a bag on the king's horse. Godfrey's men attempt to
Question: What is the name of the brown bear in the movie? | [
"little john",
"bhavana"
] | task469-01e86abc6dee4b41a7ae79f011d5ea03 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In May 1918, a conservative-monarchist Senate was formed by J. K. Paasikivi, and the Senate asked the German troops to remain in Finland. 3 March 1918 Treaty of Brest-Litovsk and 7 March German-Finnish agreements bound White Finland to the German Empire's sphere of influence. General Mannerheim resigned his post on 25 May after disagreements with the Senate about German hegemony over Finland, and about his planned attack on Petrograd to repulse the Bolsheviks and capture Russian Karelia. The Germans opposed these plans due to their peace treaties with Lenin. The Civil War weakened the Finnish Parliament; it became a Rump Parliament that included only three socialist representatives. On 9 October 1918, under pressure from Germany, the Senate and Parliament elected a German prince, Friedrich Karl, the brother-in-law of German Emperor William II, to become the King of Finland. The German leadership was able to utilise the breakdown of Russia for the geopolitical benefit of the German Empire in Fennoscandia also. The Civil War and the aftermath diminished independence of Finland, compared to the status it had held at the turn of the year 1917-1918. The economic condition of Finland deteriorated drastically from 1918; recovery to pre-conflict levels was achieved only in 1925. The most acute crisis was in food supply, already deficient in 1917, though large-scale starvation had been avoided that year. The Civil War caused marked starvation in southern Finland. Late in 1918, Finnish politician Rudolf Holsti appealed for relief to Herbert Hoover, the American chairman of the Committee for Relief in Belgium. Hoover arranged for the delivery of food shipments and persuaded the Allies to relax their blockade of the Baltic Sea, which had obstructed food supplies to Finland, and to allow food into the country.
Question: Which happened first, the Treaty of Brest-Litovsk or the German-Finnish agreements? | [
"treaty of brest-litovsk"
] | task469-218e4d74de0e474aaaa9bcb8cfc1a648 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Hubble measured the distances to galaxies. He also studied the motions of galaxies. In doing these things, Hubble noticed a relationship. This is now called Hubbles Law: The farther away a galaxy is, the faster it is moving away from us. There was only one conclusion he could draw from this. The universe is expanding! Figure 26.15 shows a simple diagram of the expanding universe. Imagine a balloon covered with tiny dots. When you blow up the balloon, the rubber stretches. The dots slowly move away from each other as the space between them increases. In an expanding universe, the space between galaxies is expanding. We see this as the other galaxies moving away from us. We also see that galaxies farther away from us move away faster than nearby galaxies. About 13.7 billion years ago, the entire universe was packed together. Everything was squeezed into a tiny volume. Then there was an enormous explosion. After this big bang, the universe expanded rapidly (Figure 26.16). All of the matter and energy in the universe has been expanding ever since. Scientists have evidence this is how the universe formed. One piece of evidence is that we see galaxies moving away from us. If they are moving apart, they must once have been together. Also, there is energy left over from this explosion throughout the universe. The theory for the origin of the universe is called the Big Bang Theory. In the first few moments after the Big Bang, the universe was extremely hot and dense. As the universe expanded, it became less dense. It began to cool. First protons, neutrons, and electrons formed. From these particles came hydrogen. Nuclear fusion created helium atoms. Some parts of the universe had matter that was densely packed. Enormous clumps of matter were held together by gravity. Eventually this material became the gas clouds, stars, galaxies, and other structures that we see in the universe today. We see many objects out in space that emit light. This matter is contained in stars, and the stars are contained in galaxies. Scientists think that stars and galaxies make up only a small part of the matter in the universe. The rest of the matter is called dark matter. Dark matter doesnt emit light, so we cant see it. We know it is there because it affects the motion of objects around it. For example, astronomers measure how spiral galaxies rotate. The outside edges of a galaxy rotate at the same speed as parts closer to the center. This can only be explained if there is a lot more matter in the galaxy than we can see. What is dark matter? Actually, we dont really know. Dark matter could just be ordinary matter, like what makes up Earth. The universe could contain lots of objects that dont have enough mass to glow on their own. There might just be a lot of black holes. Another possibility is that the universe contains a lot of matter that is different from anything we know. If it doesnt interact much with ordinary matter, it would be very difficult or impossible to detect directly. Most scientists who study dark matter think it is a combination. Ordinary matter is part of it. That is mixed with some kind of matter that we havent discovered yet. Most scientists think that ordinary matter is less than half of the total matter in the universe. We know that the universe is expanding. Astronomers have wondered if it is expanding fast enough to escape the pull of gravity. Would the universe just expand forever? If it could not escape the pull of gravity, would it someday start to contract? This means it would eventually get squeezed together in a big crunch. This is the opposite of the Big Bang. Scientists may now have an answer. Recently, astronomers have discovered that the universe is expanding even faster than before. What is causing the expansion to accelerate? One hypothesis is that there is energy out in the universe that we cant see. Astronomers call this dark energy. We know even less about dark energy than we know about dark matter. Some scientists think that dark energy makes up
Question: all the matter and energy that exists and all of space and time | [
"universe"
] | task469-ea78efee9e134823b0f8774e36aa33b6 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Here are some books published this year. The following introductions of these books may help you choose a book to your own taste. Life Simplified If you are looking for a book that will transform your life for good, Life Simplified is that book. If you are looking for a guide to inspire and lead you back to your inherent self, Life simplified will act as your compass. Life Simplified provides readers with a carefully mapped approach to create life changes. The reader will develop a sense of personal pride in their progress as each chapter is completed, motivating them further. The book is an absolute must read if you would like an uncomplicated method in positively improving your life. Building the Best You How can you become the person you've always dreamed of being? Personal transformation begins when you take stock of where you are and what you are doing right now...and work to change it. All you have to do is to answer some basic questions and take five minutes of "focus time" daily to get there. You are responding to questions like "What am I grateful for today?", "What challenged me?" and "How can I overcome that challenge?" The Gifts of Imperfection In this latest book, the writer Brown emphasizes that above all other ingredients of living an emotionally healthy life is the importance of loving ourselves. The point is to embrace life and oneself with all the imperfections, releasing the stress of overdoing and overworking. Brown offers exercises for readers to understand their own emotions and begin to develop the kind of resilience needed to refuse unrealistic expectations of others and ourselves. The Strengths Book You are remarkable. But do you always realize it? Realize your strengths and you will be realizing the best of you. Do you want to be confident, successful, and sustainably happy? Do you want to achieve your goals and enjoy better relationships? The Strengths Book reveals the sixty strengths that make us who we are. If you are a manager, a parent, a career changer, or even just you, remarkable as you are, The Strengths Book is for you. Discover your strengths--what you do best and love to do--and transform your life by realizing the best of you.
Question: Which book doesn't involve the topic of change? | [
"the gifts of imperfection."
] | task469-26daf35a7c3d417c9db96c9e342de66f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Crcavac is a village in the municipality of Leskovac, Serbia.
Question: In which country would you find Crcavac? | [
"serbia"
] | task469-8b07aad7de204dccb0b526042b3e83c7 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Autosomal dominant facioscapulohumeral muscular dystrophy (FSHD) has an unusual pathogenic mechanism. FSHD is caused by deletion of a subset of D4Z4 macrosatellite repeat units in the subtelomere of chromosome 4q. Recent studies provide compelling evidence that a retrotransposed gene in the D4Z4 repeat, DUX4, is expressed in the human germline and then epigenetically silenced in somatic tissues. In FSHD, the combination of inefficient chromatin silencing of the D4Z4 repeat and polymorphisms on the FSHD-permissive alleles that stabilize the DUX4 mRNAs emanating from the repeat result in inappropriate DUX4 protein expression in muscle cells. FSHD is thereby the first example of a human disease caused by the inefficient repression of a retrogene in a macrosatellite repeat array.
Question: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4? | [
"fshd",
"facioscapulohumeral dystrophy"
] | task469-d54bd92c129b443fa88189b82fb08c74 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Jeanne Deckers (17 October 1933 -- 29 March 1985), aka Jeannine Deckers, better known as Sur Sourire (''Sister Smile'', often credited as The Singing Nun in English-speaking countries), was a Belgian singer-songwriter and initially a member of the Dominican Order in Belgium as Sister Luc-Gabrielle.
Question: To which religious order did The Singing Nun belong? | [
"dominican order"
] | task469-e84c06e4159a40a69b495b937c24e39f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: DNA damage is preferentially repaired in the transcribed strand of many active genes. Although the concept of DNA repair coupled with transcription has been widely accepted, its mechanisms remain elusive. We recently reported that in Chinese hamster ovary cells while ultraviolet light-induced cyclobutane pyrimidine dimers (CPDs) are preferentially repaired in the transcribed strand of dihydrofolate reductase gene, CPDs are efficiently repaired in both strands of adenine phosphoribosyltransferase (APRT) locus, in either a transcribed or nontranscribed APRT gene (1). These results suggested that the transcription dependence of repair may depend on genomic context. To test this hypothesis, we constructed transfectant cell lines containing a single, actively transcribed APRT gene, integrated at different genomic sites. Mapping of CPD repair in the integrated APRT genes in three transfectant cell lines revealed two distinct repair patterns, either preferential repair of CPDs in the transcribed strand or very poor repair in both strands. Similar kinetics of micrococcal nuclease digestion were seen for all three transfectant APRT gene domains and endogenous APRT locus. Our results suggest that both the efficiency and strand-specificity of repair of an actively transcribed gene are profoundly affected by genomic context but do not reflect changes in first order nucleosomal structure.
Question: Which gene strand is targeted by transcription-coupled repair (TCR)? | [
"the transcribed strand"
] | task469-afaa29627fcb459389c12e57d7b28786 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: With the avalanche of biological sequences generated in the post-genomic age, one of the most challenging problems in computational biology is how to effectively formulate the sequence of a biological sample (such as DNA, RNA or protein) with a discrete model or a vector that can effectively reflect its sequence pattern information or capture its key features concerned. Although several web servers and stand-alone tools were developed to address this problem, all these tools, however, can only handle one type of samples. Furthermore, the number of their built-in properties is limited, and hence it is often difficult for users to formulate the biological sequences according to their desired features or properties. In this article, with a much larger number of built-in properties, we are to propose a much more flexible web server called Pse-in-One ([Link] which can, through its 28 different modes, generate nearly all the possible feature vectors for DNA, RNA and protein sequences. Particularly, it can also generate those feature vectors with the properties defined by users themselves. These feature vectors can be easily combined with machine-learning algorithms to develop computational predictors and analysis methods for various tasks in bioinformatics and system biology. It is anticipated that the Pse-in-One web server will become a very useful tool in computational proteomics, genomics, as well as biological sequence analysis. Moreover, to maximize users' convenience, its stand-alone version can also be downloaded from [Link] and directly run on Windows, Linux, Unix and Mac OS.
Question: Which server is used for generating modes of pseudo components of DNA, RNA and protein sequences? | [
"pse-in-one"
] | task469-cb7842e001af4955bdf9e11c5e588863 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Stress is the force applied to an object. In geology, stress is the force per unit area that is placed on a rock. Four types of stresses act on materials. A deeply buried rock is pushed down by the weight of all the material above it. Since the rock cannot move, it cannot deform. This is called confining stress. Compression squeezes rocks together, causing rocks to fold or fracture (break) (Figure 1.1). Compression is the most common stress at convergent plate boundaries. Stress caused these rocks to fracture. Rocks that are pulled apart are under tension. Rocks under tension lengthen or break apart. Tension is the major type of stress at divergent plate boundaries. When forces are parallel but moving in opposite directions, the stress is called shear (Figure 1.2). Shear stress is the most common stress at transform plate boundaries. Shearing in rocks. The white quartz vein has been elongated by shear. When stress causes a material to change shape, it has undergone strain or deformation. Deformed rocks are common in geologically active areas. A rocks response to stress depends on the rock type, the surrounding temperature, the pressure conditions the rock is under, the length of time the rock is under stress, and the type of stress. Rocks have three possible responses to increasing stress (illustrated in Figure 1.3): elastic deformation: the rock returns to its original shape when the stress is removed. plastic deformation: the rock does not return to its original shape when the stress is removed. fracture: the rock breaks. Under what conditions do you think a rock is more likely to fracture? Is it more likely to break deep within Earths crust or at the surface? What if the stress applied is sharp rather than gradual? At the Earths surface, rocks usually break quite quickly, but deeper in the crust, where temperatures and pressures are higher, rocks are more likely to deform plastically. Sudden stress, such as a hit with a hammer, is more likely to make a rock break. Stress applied over time often leads to plastic deformation. Click image to the left or use the URL below. URL:
Question: force per unit area that is placed on an object. | [
"stress"
] | task469-122abedc032e442eaa0ce2a90842e3cd | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Salil Shetty (born 3 February 1961) is an Indian human rights activist who currently serves as Secretary General of the human rights organization Amnesty International (2010--present).
Question: What is Salil Shetty's place of employment? | [
"amnesty international"
] | task469-5a58f840d79a49a598e1e864295c6d6d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: BACKGROUND Fractionated plasma separation and absorption (FPSA) is an extracorporeal liver support method that detoxifies accumulated toxins. There are limited data of its use in the treatment of Amanita phalloides intoxication. The objective of this study was to investigate whether FPSA before liver transplantation improves patients' short-term post liver transplantation survival in Amanita phalloides poisoning. MATERIAL AND METHODS The study population consisted of ten patients who had liver transplantation (LT) due to acute liver failure (ALF) caused by Amanita phalloides poisoning. Six patients were treated with FPSA before liver transplantation. All the patients who were started on FPSA were also placed on the liver transplantation list according to emergent liver transplantation criteria. RESULTS Patients treated with FPSA were in a more severe clinical condition presenting in higher mean MELD, total bilirubin, INR and ammonia along with more frequent hypoglycemia and hepatic encephalopathy grade 3/4. FPSA group had longer mean waiting time on the recipient list (3.5 vs. 1.25 days) but inferior thirty-day survival rate (16.5% vs. 100%). CONCLUSIONS When conservative medical modalities are ineffective, the only treatment for Amanita phalloides poisoning is a liver transplant. Although FPSA treated patients had inferior post-LT survival, FPSA was found to prolong the pre surgical waiting time for critically ill patients, consequently giving a chance of life-saving procedure.
Question: Which mushroom is poisonous, Amanita phalloides or Agaricus Bisporus | [
"amanita phalloides"
] | task469-ae0e8f0f1c5f47bd855018296b4f53de | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Infections generally occur in intravenous drug abuse (IVDA) patients, most commonly affecting the spine and proximal joints. Numerous serious musculoskeletal complications of IVDA may involve the upper extremity, however. Soft-tissue complications in the upper extremity of IVDA patients include cellulitis, ulceration, abscess, pyomyositis, septic bursitis, tenosynovitis, and necrotizing fasciitis. Foreign bodies in soft tissue due to needle fragments are common findings. Primary bone and joint IVDA complications include osteomyelitis (acute and chronic) and septic arthritis. Other IVDA complications in the upper extremity affecting blood vessels and lymphatics include hematoma, arterial aneurysm and pseudoaneurysm, thrombosis, thrombophlebitis, "puffy hand" syndrome, and lymphadenopathy. These complications usually present as urgent issues requiring prompt and accurate evaluation in the acute setting. Diagnostic imaging not only aids in making the correct diagnosis but also permits precise definition of the location and extent of these abnormalities. We review the imaging findings and illustrate a wide range of disabling and even life-threatening complications affecting the upper extremity of IVDA patients that require early diagnosis for optimal outcome.
Question: What causes "Puffy hand syndrome"? | [
"intravenous drug abuse"
] | task469-8ae65161a390457fa04e36c6fdd29805 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: SAN FRANCISCO--The "Reading Wizard", an 11 - year - old - boy, whose offer to read to children without being paid at a local library was refused by libraries, will get to read to younger kids after all. Mayor Willie Brown last Wednesday ordered San Francisco Public Library officials to allow John O'Connor to read to preschool children to get them interested in books and stop them from watching television and video games. "I didn't expect this kind of attention. " John said, "It's just shocking." John has chosen his first book, "The King's Giraffe", and made up fliers inviting neighborhood children, aged from three to six, to the Presidio Branch every Wednesday afternoon. He planned to call himself the "Reading Wizard" and wear a special hat, fake glasses and a black coat. But his idea was refused - on the phone, in person and finally with a letter from Toni Bernardi, the chief of the library's children and youth services. Using terms like "age appropriate material" ,she wrote that only library workers are allowed to read to children. John then went to a member of the city board of supervisors , who advised him to write letters to the library officials. "Our libraries are supposed to turn kids on, not to turn them off." Brown said he enjoyed "the creative idea, the sense of civic duty and the caring for others that John clearly showed us."
Question: Who is the "Reading Wizard"? | [
"john o'connor."
] | task469-758dc343a53b4a8e9e45bcd2fac6990b | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The history of the atom begins around 450 B.C. with a Greek philosopher named Democritus (see Figure 5.7). Democritus wondered what would happen if you cut a piece of matter, such as an apple, into smaller and smaller pieces. He thought that a point would be reached where matter could not be cut into still smaller pieces. He called these "uncuttable" pieces atomos. This is where the modern term atom comes from. Democritus was an important philosopher. However, he was less influential than the Greek philosopher Aristotle, who lived about 100 years after Democritus. Aristotle rejected Democrituss idea of atoms. In fact, Aristotle thought Around 1800, a British chemist named John Dalton revived Democrituss early ideas about the atom. Dalton is pictured in Figure 5.8. He made a living by teaching and just did research in his spare time. Nonetheless, from his research results, he developed one of the most important theories in science. Dalton did many experiments that provided evidence for atoms. For example, he studied the pressure of gases. He concluded that gases must consist of tiny particles in constant motion. Dalton also researched the properties of compounds. He showed that a compound always consists of the same elements in the same ratio. On the other hand, different compounds always consist of different elements or ratios. This can happen, Dalton reasoned, only if elements are made of tiny particles that can combine in an endless variety of ways. From his research, Dalton developed a theory of the atom. You can learn more about Dalton and his research by watching the video at this URL: (9:03). MEDIA Click image to the left or use the URL below. URL: The atomic theory Dalton developed consists of three ideas: All substances are made of atoms. Atoms are the smallest particles of matter. They cannot be divided into smaller particles. They also cannot be created or destroyed. All atoms of the same element are alike and have the same mass. Atoms of different elements are different and have different masses. Atoms join together to form compounds. A given compound always consists of the same kinds of atoms in the same ratio. Daltons theory was soon widely accepted. Most of it is still accepted today. The only part that is no longer accepted is his idea that atoms are the smallest particles. Scientists now know that atoms consist of even smaller particles. Dalton incorrectly thought that atoms are tiny solid particles of matter. He used solid wooden balls to model them. The sketch in the Figure 5.9 shows how Daltons model atoms looked. He made holes in the balls so they could be joined together with hooks. In this way, the balls could be used to model compounds. When later scientists discovered subatomic particles (particles smaller than the atom itself), they realized that Daltons models were too simple. They didnt show that atoms consist of even smaller particles. Models including these smaller particles were later developed. The next major advance in the history of the atom was the discovery of electrons. These were the first subatomic particles to be identified. They were discovered in 1897 by a British physicist named J. J. Thomson. You can learn more about Thomson and his discovery at this online exhibit: . Thomson was interested in electricity. He did experiments in which he passed an electric current through a vacuum tube. The experiments are described in Figure 5.10. Thomsons experiments showed that an electric current consists of flowing, negatively charged particles. Why was this discovery important? Many scientists of Thomsons time thought that electric current consists of rays, like rays of light, and that it is positive rather than negative. Thomsons experiments also showed that the negative particles are all alike and smaller than atoms. Thomson concluded that the negative particles couldnt be fundamental units of matter because they are all alike. Instead, they must be parts of atoms. The negative particles were later named electrons. Thomson knew that atoms are neutral in electric charge. So how could atoms contain negative particles? Thomson thought that the rest of the atom must be positive to cancel out the negative charge. He said that an atom is like
Question: Which statement is part of Daltons atomic theory? | [
"all substances are made of atoms."
] | task469-d5031ff9ed4c4f628dea5e12713fbefa | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Browns traveled to Indianapolis to take on an Andrew Luck-led Colts offense. The Colts were able to score in the first quarter as Andrew Luck ran for a 3-yard touchdown making the score 7-0 for the only score of the game. The Browns responded in the 2nd quarter coming within a point when Brandon Weeden found Greg Little on a 14-yard pass (with a failed PAT) making the score 7-6. Then, Luck ran for another touchdown this time from 5 yards out to make the score 14-6 at halftime. The Browns came within a point again in the 3rd quarter as Weeden found Josh Gordon on a 33-yard pass making the score 14-13 but the Colts wrapped things up with Adam Vinatieri's 38-yard field goal followed by a scoreless 4th quarter making the final score 17-13 as the Browns' road record at this point of the season was 0-4 while their record overall was 1-6.
Question: Which team scored more points in the first half? | [
"colts"
] | task469-154935b8b1954997943d14f7995109e9 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Jean-Francois Lyotard (French: ( fswa ljta); 10 August 1924 -- 21 April 1998) was a French philosopher, sociologist, and literary theorist.
Question: What is the language of Jean-Francois Lyotard? | [
"french"
] | task469-87bf5f8e85e4469a956ccce4c408631c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Eukaryotic cells have many specific functions, so it can be said that a cell is like a factory. A factory has many machines and people, and each has a specific role. Just like a factory, the cell is made up of many different parts. Each part has a special role. The different parts of the cell are called organelles, which means "small organs." All organelles are found in eukaryotic cells. Prokaryotic cells are "simpler" than eukaryotic cells. Though prokaryotic cells still have many functions, they are not as specialized as eukaryotic cells, lacking membrane-bound organelles. Thus, most organelles are not found in prokaryotic cells. Below are the main organelles found in eukaryotic cells ( Figure 1.1): 1. The nucleus of a cell is like a safe containing the factorys trade secrets. The nucleus contains the genetic material (DNA), the information needed to build thousands of proteins. 2. The mitochondria are the powerhouses of the cell. Mitochondria are the organelles where cellular energy is produced, providing the energy needed to power chemical reactions. This process, known as cellular respiration, produces energy is in the form of ATP (adenosine triphosphate). Cells that use a lot of energy may have thousands of mitochondria. 3. Vesicles are small membrane bound sacs that transport materials around the cell and to the cell membrane. 4. The vacuoles are like storage centers. Plant cells have larger vacuoles than animal cells. Plants store water and nutrients in their large central vacuoles. 5. Lysosomes are like the recycling trucks that carry waste away from the factory. Lysosomes have digestive enzymes that break down old molecules into parts that can be recycled. 6. In both eukaryotes and prokaryotes, ribosomes are the non-membrane bound organelles where proteins are made. Ribosomes are like the machines in the factory that produce the factorys main product. Proteins are the main product of the cell. 7. Some ribosomes can be found on folded membranes called the endoplasmic reticulum (ER), others float freely in the cytoplasm. If the ER is covered with ribosomes, it looks bumpy like sandpaper, and is called the rough endoplasmic reticulum. If the ER does not contain ribosomes, it is smooth and called the smooth endoplasmic reticulum. Many proteins are made on the ribosomes on the rough ER. These proteins immedi- ately enter the ER, where they are modified, packaged into vesicles and sent to the Golgi apparatus. Lipids are made in the smooth ER. 8. The Golgi apparatus works like a mail room. The Golgi apparatus receives proteins from the rough ER and puts "shipping addresses" on them. The Golgi then packages the proteins into vesicles and sends them to the right place in the cell or to the cell membrane. Some of these proteins are secreted from the cell (they exit the cell); others are placed into the cell membrane. Also, the cytoskeleton gives the cell its shape, and the flagella helps the cell to move. Prokaryotic cells may also have flagella.
Question: which organelle houses the dna, the genetic material of the cell? | [
"the nucleus"
] | task469-a6b0e60e58854cd2a282ec0ccb34f9cb | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Roland Teichmann (born April 19, 1970 in Salzburg, Austria) is the director of the Austrian Film Institute.
Question: Which country does Roland Teichmann belong to? | [
"austria"
] | task469-420fe4bcae814d1290227bcb7edf45ec | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Mohammad Reza Tahmasebi (born 21 March 1976) is an Iranian retired Football player who currently coaches Paykan of the Iran Pro League.
Question: Where was Mohammad Reza Tahmasebi from? | [
"iran"
] | task469-5403885566fa4d7a9ac15184406ac06c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Have you ever been to the ocean or eaten seafood? If you have, then youve probably encountered members of Phylum Mollusca. In addition to snails, mollusks include squids, slugs, scallops, and clams. You can see a clam in Figure 12.15. There are more than 100,000 known species of mollusks. Some mollusks are nearly microscopic. The largest mollusk, the colossal squid, may be as long as a school bus and weigh over half a ton! Watch this short video to see an amazing diversity of mollusks: . MEDIA Click image to the left or use the URL below. URL: Mollusks have a true coelom and complete digestive system. They also have circulatory and excretory systems. They have a heart that pumps blood, and organs that filter out wastes from the blood. You can see some other traits of mollusks in the garden snail in Figure 12.16. Like the snail, many other mollusks have a hard outer shell. It is secreted by special tissue called mantle on the outer surface of the body. The shell covers the top of the body and encloses the internal organs. Most mollusks have a distinct head region. The head may have tentacles for sensing the environment and grasping food. Mollusks generally have a muscular foot, which may be used for walking or other purposes. A unique feature of mollusks is the radula. This is a feeding organ with teeth made of chitin. It is located in front of the mouth in the head region. It can be used to scrape algae off rocks or drill holes in the shells of prey. You can see the radula of the sea slug in Figure 12.17. Mollusks reproduce sexually. Most species have separate male and female sexes. Fertilization may be internal or external, depending on the species. Fertilized eggs develop into larvae. There may be one or more larval stages. Each one is different from the adult stage. Mollusks live in most terrestrial, freshwater, and marine habitats. However, the majority of species live in the ocean. They can be found in both shallow and deep water and from tropical to polar latitudes. They have a variety of ways of getting food. Some are free-living heterotrophs. Others are internal parasites. Mollusks are also eaten by many other organisms, including humans. Annelids are segmented worms in Phylum Annelida. There are about 15,000 species of annelids. They range in length from less than a millimeter to more than 3 meters. To learn more about the amazing diversity and adaptations of annelids, watch this excellent video: [Link] MEDIA Click image to the left or use the URL below. URL: Annelids are divided into many repeating segments. The earthworm in Figure 12.18 is an annelid. You can clearly see its many segments. Segmentation of annelids is highly adaptive. Each segment has its own nerve and muscle tissues. This allows the animal to move very efficiently. Some segments can also be specialized to carry out particular functions. They may have special structures on them. For example, they might have tentacles for sensing or feeding, paddles for swimming, or suckers for clinging to surfaces. Annelids have a large coelom. They also have several organ systems. These include a: circulatory system; excretory system; complete digestive system; and nervous system, with a brain and sensory organs. Most annelids can reproduce both asexually and sexually. Asexual reproduction may occur by budding or fission. Sexual reproduction varies by species. Some species go through a larval stage before developing into adults. Other species grow to adult size without going through a larval stage. Annelids live in a diversity of freshwater, salt-water, and terrestrial habitats. They vary in what they eat and how they get their food. Some annelids, such as earthworms, eat soil and extract organic material from it. Annelids called leeches are either predators or parasites. Some leeches capture and eat other invertebrates. Others feed off the blood of vertebrate hosts. Annelids called polychaete worms live on the ocean floor. They may be filter feeders, predators, or scavengers. The amazing feather duster worm in Figure 12.19 is a polychaete that has a fan-like crown of
Question: ___special tissue on the outer surface of a mollusk that secretes a shell | [
"mantle"
] | task469-e4cc118595cb4a6aa30343e7c1db56d5 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Clay gets up from his trailer at the beach and drives to Mr. Jimmy's lush house, where he mows the lawn.Mr. Jimmy has a visit from David, who is concerned about his health. He then goes out to chat with Clay, his new gardener, and invites him to swim in the pool after he is done working. Clay says he needs to do another lawn later.An academic named Edmund Kay comes to visit Mr. Jimmy, and expresses his deep enthusiasm for his films. Jimmy takes him out back to the pool, and recalls his youth in London, and then his movement into movies and on to Hollywood.Mr. Jimmy becomes bored with Kay's questions, and suggests that Kay begin removing clothing in exchange for his answers. Kay begins disrobing to each of Jimmy's tales about homosexuals in Hollywood and making Frankenstein.Jimmy then gets lightheaded and needs Kay's help to get inside and lie down. His maid Hanna scolds him for chasing boys after just returning from the hospital.Jimmy goes to a doctor who explains that he had a stroke which has left his brain somewhat impaired.Jimmy sees Clay working out in the garden and invites him to talk over iced tea in his painting studio. Jimmy tells him he directed the first two Frankenstein movies, and they talk about his paintings. Jimmy tells Clay he has an expressive head and asks him to model for pay; Clay agrees.Clay arrives at Jimmy's house and Hanna asks if he is going to hurt him. Clay is confused, and she withdraws the question. Clay sits down in the studio to model for Jimmy, who asks him to remove his shirt, even though he only plans to draw his face. Jimmy begins to draw, telling Clay of a memory he has about eating fat drippings as a poor child. He explains how different he was from his family, more talented, more intelligent.Clay goes to a bar and boasts that a famous director is drawing him. Betty the bartender, whom Clay has slept with, turns on The Bride of Frankenstein on TV; meanwhile, Jimmy watches at home with Hanna. The others at the bar criticize the film for not being scary. Clay seems to understand the monster's feelings of loneliness.Flashback: Jimmy directs the performers on the set of Bride of Frankenstein.Clay and Betty talk outside the bar, and he gets upset that she does not want to sleep with him again.Clay calls his parents from a payphone but does not want to talk much.Jimmy dreams that Clay is Dr. Frankenstein, replacing his brain and electrifying him.Hanna tells Clay that Jimmy would like him to have lunch. The two talk as she cooks, and Hanna tells him he should be married. Hanna tells Clay that Jimmy commits unspeakable sins of the flesh, buggery. She is surprised that Clay did not know.Jimmy and Clay have a rather fancy lunch. Jimmy tells Clay that he had hoped Bride of Frankenstein would be seen as a comedy. Jimmy asks Clay to pose for an hour after lunch, and he declines. Jimmy explains that he had a "husband" named David, and Clay asks about his homosexuality. They smoke cigars, and Clay agrees to pose.During the sitting, Jimmy talks about how he made the successful Show Boat and then tried to make his WWI masterpiece The Road Back but the studio butchered it. He says he always wanted to go back to movies, but that was the end. He also broke up with David thereafter. Jimmy begins to describe how he used to have many male models, all naked, which upsets Clay so much he gets mad and storms out.Clay goes to Betty's bar but she is not there. He finds another woman and has sex with her in the parking lot.Clay returns to Jimmy's house and says he will sit for him again if he eases up on the locker room talk. Jimmy is curious that Clay has never known any gay men before, not even when he was in the Marines. Jimmy recalls a young soldier from WWI he mentored in the trenches, then becomes quite upset, looking at Clay intensely
Question: Who is befriend with handsome gardener and former Marine? | [
"jimmy",
"whale"
] | task469-941dbc49ac484d159281967bf888eede | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Come for Dinner by Leslie Revsin Make every meal a feast and every moment with loved ones an occasion with Come for Dinner. Revsin, the former owner and chef of Manhattan's Restaurant Leslie, offers a collection of over 150 recipes designed for small get-togethers of friends and family. There are various ethnic dishes that draw from Asia,the Mediterranean, Latin cultures and more. Revsin believes cooking at home provides the opportunity to connect with friends and family on a good level. Retro Beach Bash by Linda Everett Grab your beach blanket and your surfboard -- it's time for a beach party! With more than 100 recipes for beach picnics and barbecues, Retro Beach Bash, is the beach lover's companion for fun in the sun. Half information and half cookbook, you can browse the pages that are filled with beach fun tips and advice. The second half of this book is a cookbook, complete with delicious picnic and grilled foods to satisfy every taste on the beach. Entertaining Edibles by Sidney Escowitz You've seen them decorating plates at restaurants, admired them at weddings, and expressed great surprise at the chefs who designed them -- and now you can produce them at home. Sidney shares lots of practical tips that will give your finished food sculptures a professional look and send you on your way towards creating your own original works of food art. Recipes from a Tapas Bar by Olivier Said If you're a fan of Spanish Tapas bars, this book is a must-have for your library. Even if you don't cook, you'll still want this book if you're a fan of Tapas bars, only for the lively discussions of the cheeses of Spain along with other Spanish wines and spirits.
Question: Who can tell you how to make the works of food art? | [
"sidney escowitz."
] | task469-aacf48b3701c4bb9ae8e674f02741534 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: When once-wealthy string magnate Rudolf Smuntz (William Hickey) dies, he leaves his outdated string factory and a run-down mansion to his two sons, Lars (Lee Evans) and Ernie (Nathan Lane). When Lars refuses a proposal by representatives from the large Zeppco conglomerate to purchase their string factory, his wife April (Vicki Lewis) throws him out. Meanwhile, Ernie serves Mayor McKrinkle (Cliff Emmich) at his restaurant in anticipation of becoming a famous chef for serving such a high-profile guest. However, the mayor is poisoned by a cockroach (which came from Rudolf's old box of Cuban cigars that Ernie took for himself) and suffers two heart attacks, with the latter fatal. As a result, Ernie's restaurant is closed down by the Board of Health. Finding blueprints of the mansion that they decide to live in, Ernie and Lars discover that it is a lost masterpiece designed by famous architect Charles Lyle LaRue. LaRue collector Alexander Falko (Maury Chaykin) makes a proposal, but Ernie refuses under the belief they can make a larger profit by restoration and auction. However, the brothers have already realized that the house has one stubborn occupant: a tiny and treacherous mouse. When a single mousetrap proved to be useless against the mouse, Ernie and Lars cover the entire kitchen floor with a number of mousetraps, but end up trapped in the kitchen when the door is locked. The mouse slips through the maze of traps with ease and drops a cherry, setting off the mousetraps in a dominoes effect. The brothers attempt to kill the mouse with a vacuum cleaner, but are covered with sewage. The brothers purchase a monstrous cat named "Catzilla" to deal with the mouse. Catzilla chases the mouse throughout the house while destroying everything, but gets tricked onto the house's dumbwaiter as the mouse sends him on a one-way trip down to his demise. They then hire an eccentric exterminator named Caesar (Christopher Walken) to handle the mouse, though he is severely injured and hospitalized. Later, Ernie chases the mouse up a chimney and gets stuck, and Lars attempts to light a match while the mouse starts a gas leak, creating an explosion that blasts Ernie out of the chimney and into the lake. Ernie takes a shotgun to fire at the mouse, accidentally shooting a compressed can of pesticide that Caesar left behind, making a large hole. After the two recover, Lars throws an orange at Ernie, but accidentally knocks the mouse unconscious. Unable to finish him off, they instead seal the mouse in a box and mail him to Fidel Castro in Cuba. The brothers reconcile again and finish renovating the house. When the night of the auction arrives, Lars discovers the mouse's box in the snow returned due to insufficient postage and with a big hole gnawed through it. Lars and Ernie panic upon seeing the mouse return, but attempt to maintain their composure as the auction continues. The mouse also devours Rudolf's "lucky string," which he gave to the brothers before his death, making their vendetta even more personal. The brothers desperately attempt to flush out the mouse by feeding a hose into the wall. As the auction reaches a record $25 million bid, the house rapidly floods through the walls and the floors, causing everyone to be washed out of the house as it promptly collapses. The brothers' only consolation is the fact that the mouse must finally be dead as their father's "lucky string" is found in the wreckage. With nowhere else to go, the brothers return to the factory and fall asleep, with only a single chunk of cheese for food. Having followed them, the mouse restarts and feeds the cheese into the machinery inventing the world's first string cheese, which inspires Ernie and Lars. Ernie and Lars end their war with the mouse and have successfully rebuilt the factory as a novelty string cheese company. Lars has begun a relationship with one of the two sisters Hilde, and Ernie puts his culinary skill to work in developing new cheese flavors with the mouse as his personal taste-tester.
Question: Who has owns a famous restaurant? | [
"ernie"
] | task469-9df0d456a60e495d8905c655b9af79f2 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Dele Adeleye and Sani Kaita- through a statement on their official website, FC Tavria, Dele Adeleye, in the Nigeria squad for two live-wire games against Madagascar on Sunday, comes from Donetsk Metallurg, where he scored three goals in 26 appearances from central defense.
Question: What is Dele Adeleye's country of original? | [
"nigeria"
] | task469-c01a2de18fae49a69ec34f2ea0be1c63 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Hoping to rebound from a tough loss to the Patriots, the Bills would play their Week 2 home opener in an interconference duel with the Tampa Bay Buccaneers. This would be the first time that Buffalo ever hosted Tampa Bay in a regular season game, having played a preseason game with each other in 1977. In the first quarter, the Bills came out firing as quarterback Trent Edwards completed a 32-yard touchdown pass to wide receiver Lee Evans, safety Donte Whitner returning an interception 76 yards for a touchdown and kicker Rian Lindell making a 31-yard field goal. The Buccaneers would get on the board in the second quarter as quarterback Byron Leftwich completed a 42-yard touchdown pass to tight end Kellen Winslow, while Buffalo replied with Lindell getting a 43-yard field goal. Tampa Bay would close out the half as Leftwich completed an 8-yard touchdown pass to running back Carnell "Cadillac" Williams. After a scoreless third quarter, the Bills began to pull away as Lindell got a 43-yard field goal and Edwards completed a 43-yard touchdown pass to wide receiver Terrell Owens. The Buccaneers tried to rally as Leftwich completed a 6-yard touchdown pass to tight end Jerramy Stevens (with a failed two-point conversion), yet Buffalo closed out the game with Lindell nailing a 20-yard field goal. With the win, the Bills improved to 1-1.
Question: Who threw the second longest touchdown pass? | [
"leftwich"
] | task469-b8987bc532fa40cd8386ff5a1ef64e67 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: General Sir Alfred Dudley Ward GCB, KBE, DSO (27 January 1905--28 December 1991), was a senior officer of the British Army who saw service during World War II and later became Governor of Gibraltar.
Question: What branch was Alfred Dudley Ward part of? | [
"british army"
] | task469-4ef8264f83fc496c86da4b5ecc0207ca | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The plot is 24 hours in the life of a glamorous fashion photographer named Thomas (David Hemmings), inspired by the life of an actual "Swinging London" photographer, David Bailey.In the opening scene, Thomas wakes up after spending the night at a doss house where he has taken pictures for a book of art photos. He is late for a photo shoot with Veruschka von Lehndorff (playing herself) at his studio, which in turn makes him late for a shoot with other models later in the morning. He grows bored and walks off, leaving the models and production staff in the lurch. As he leaves the studio, two teenage girls who are aspiring models, a blond (Jane Birkin) and a dark-haired brunette (Gillian Hills) ask to speak with him, but the photographer drives off to look at an antiques shop.Wandering into Maryon Park, he takes photos of two lovers making out. The woman (Vanessa Redgrave) is furious at being photographed and demands that Thomas hand over the film, but he refuses. When she walks away to rejoin her boyfriend, he is gone and she runs away with Thomas taking photos of her as she runs.Thomas then meets his agent for lunch, and notices a man following him and looking into his car. Back at his studio, the mysterious woman from the park arrives asking for the film, but he refuses. The woman introduces herself as 'Jane' and tries to seduce Thomas by removing her top to entice him to hand over the film and negatives. Thomas agrees without going any further, but he deliberately hands Jane a different roll. She in turn writes down a telephone number to give to him.After Jane leaves, Thomas begins work on developing his photos that he took that day. His many enlargements of the black and white film are grainy but he finds something strange. In the Maryon Park photos, Thomas notices a figure hiding in the bushes near Jane and her boyfriend and upon enlarging them in a series of 'blow-up' shots, sees that it is a man with a gun (the same man he saw following him earlier). In the shots where Jane is running away with her back to the camera, Thomas also notices something on the ground in the distance. The blow-up shots of the blurred figure on the ground that Jane is running to appears to be a body in the grass. Thomas gets the feeling that he just witnessed the before and afterwards of a murder.Thomas is disturbed by a knock on the door, but it is only the two girls again, with whom he has a group-sex romp in his studio and falls asleep. Awakening, he finds they hope he will photograph them but he tells them to leave, saying, "Tomorrow! Tomorrow!"As evening falls, Thomas goes back to the park to investigate and finds a dead body (Jane's dead lover), but he has not brought his camera and is scared off by a twig breaking, as if being stepped on by someone unseen watching him. Thomas returns to his studio to find that someone (possibly Jane and her gunman accomplice) has broken into his place and all the negatives and prints from the park are gone except for one large, very grainy blowup showing the body (which proves nothing). He tries to call the phone number Jane gave him, but learns from the operator that the number does not exist.After driving into town, Thomas sees Jane walking alone on a sidewalk and he pulls his car over and follows her on foot into a night club where The Yardbirds, featuring both Jimmy Page and Jeff Beck on guitar, are seen playing. Thomas moves to confront Jane, but she sees him and runs. Thomas loses her on the crowded street.Thomas then goes to a drug-drenched party in a house on the Thames near central London. He finds a strung-out Veruschka, who had told him that she was going to Paris, and when confronted, she says she is in Paris. Thomas then meets his agent Ron (Peter Bowles), whom he wants to bring to the park
Question: what did the photographer not bring with him? | [
"his camera."
] | task469-30a3c104106b45e592acbd136263e735 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Harvey Shine (Dustin Hoffman) works as a jingle writer for television commercials in Manhattan, a job not in keeping with his one-time aspiration to be a jazz composer and pianist. We see him at work and he is very good at what he does. However, his boss does not seem impressed with his latest output. As Harvey departs for London to attend his daughter Susan's wedding, his boss actually suggests that he spend more time there than he had originally planned. Harvey declines, making the point that he needs to be back for an upcoming pitch to an old client. His boss insists that it is being done by other musicians, and that Harvey's latest work was his last chance to keep his job.On the plane, Harvey tries to chat up a fellow passenger, but she is having none of it. He is left sitting there with egg on his face and we come to regard him as even more of a loser.Meanwhile, we witness the mildly strained relationship between Kate Walker (Emma Thompson), a single Londoner, and her mother, whose husband left years earlier. Kate tries to reassure her mother that despite being single, she may yet find a man. Further, Kate tells her mom to quit worrying about the new Polish neighbor who has moved in next door and seems to be stacking a lot of firewood.Upon arrival at Heathrow Airport in London, Harvey encounters Kate at her job collecting statistics from passengers as they pass through the terminals. She attempts to question him about his reasons for visiting the UK. Tired and anxious to get to his hotel, Harvey brusquely dismisses her when she approaches him to ask questions.Harvey heads for the hotel to check in and discovers that he is the first one to arrive. Upon calling his daughter to double check where everyone else is when they were all supposed to be staying together, he learns that his ex-wife Jean actually rented a house to accommodate family and friends from the States and he is the only one at the hotel.After a brief nap, he showers and hurriedly dresses. On the way to the rehearsal dinner in the taxi cab, he realizes the anti-shoplifting device is still attached to the sleeve of his jacket. And to make matter worse, he has worn a white suit (thinking this was requested) while all the other men wore black. During the meal, it becomes increasingly clear Harvey is considered a mere guest and the role of father of the bride has been delegated to Jean's husband Brian. To add insult to injury, Brian stands to give the toast, and recollects the vacation they all spent in Rome, and his stepson-in-law-to-be embraces him and calls him Dad. Just before leaving back to his hotel, when Harvey tells Susan (with whom he has shared a strained relationship since his divorce) that he will be attending the ceremony but not the subsequent reception because he needs to return to the States for an important meeting, she informs him she has asked Brian to give her away.Meanwhile, Kate is set up on a blind date by a well meaning co-worker that does not go well. When she returns to the table after taking yet another call from her mother, she discovers her younger date has invited some of his younger friends to join them. Feeling unwanted and excluded from the conversation, she eventually excuses herself and goes home. As it turns out, Kate's increasingly neurotic mother seems convinced that her Polish neighbor is some kind of murderer because she sees him toting strange looking, lumpy packages into a shed in the back yard.The following morning Harvey attends Susan's wedding, but heavy traffic delays his arrival back to Heathrow, and he misses his plane. When he calls his boss Marvin in NYC to inform him he will be returning a day later than planned and that he will try to get there as soon as possible, he is told that he is fired.In his glum mood, Harvey makes his way to the airport bar and starts slugging down scotch, determined to drown his sorrows. Kate is sitting in the lounge reading
Question: Who does he run into at the airport bar? | [
"kate"
] | task469-7b8b9d760ce544d0aabd8fcedc30016e | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: ''Let's Get Excited'' is the third single (second in Brazil) from Alesha Dixon's second album, The Alesha Show, released by Asylum Records.
Question: What label was responsible for Let's Get Excited? | [
"asylum records"
] | task469-e2552b6ce6a54f3db07886969c52d813 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The scene opens with Ellen (Sharon Stone) riding across the prairie toward a town, when an idiot digging multiple holes looking for his gold, shoots at her. She falls off her horse and knocks him out as he checks to see if she is dead. After chaining him to his wagon, she continues into town. A large, single elimination gun fighting tournament is about to begin and she is looking for revenge on the man ( Herod/Gene Hackman) who killed her father. She arrives at the bar/hotel. Ace Hanlon shows off his deck of cards with an ace for every man he has killed. Soon, the saloon comes to life as Scars who just got out of jail, comes back to settle a score. He makes a move on Ellen, and she tells him to take a bath. Scars gets angry and kicks the blind boy's peddling wagon, as he was talking to Ellen. Later at the drafting of the tournament, the saloon owner is to sign up 16 gunfighters. Among them are The Kid (Leonardo DiCaprio), Sgt. Cantrell (Kieth David), Cort, the marksman and odds on favorite (Russell Crowe) though he was signed up against his will. Cort was an outlaw who became a preacher and built a mission. Since he was one of Herod's partners in crime, Herod now wants Cort dead. Also in the contest is Ace Hanlon ( Lance Herrickson), A Swedish Champ. and of course Herod. Anyone can challenge anyone, and each fighter must accept the first challenge. Ellen is challenged by the idiot who was digging for his lost gold. But up first was the Kid and he quickly shot the Swede and the winner is the last standing.The Swede was shot twice and then threw his gun down. Also winning, were Stg. Cantrell, Scars, and Eugene the scumbag. Herod has challenged Ace(because he thinks Ace was hired to kill him) and one of Herod's men challenged Cort. After Rusty, another of Herod's men has beaten Cort up as he was chained to a fountain in the middle of the village. Herod has Cort released so that he can go to the Kid's gun store. Herod gives Cort the cheapest gun in the place. The Kid also has told everyone that Herod was his father. Herod denies that and rubs it in the Kid's face. Then Cort went out to a fight that he refused to be in. But when the clock stuck, only one bullet was fired. Herod's man fell to the ground. Many claimed to be the fastest gun in town, like the Kid, Herod, and Ace, but all knew that Cort was the fastest. Next, Ace is bragging and doing gun tricks. It is time for he and Herod to face each other. Herod proves that Ace has been lying about all of his kills. The clock strikes and Herod blows Ace's right thumb off. Then he shoots Ace's left hand. Then after mocking Ace some more, Herod's shoots him in the chest. Then Ellen wins her first fight with Cort's help. The next day, Herod invites Stg. Cantrel to his home. He tells the Sgt, that he knows that he was the hired hand and not Ace. The Sgt. does not tell him much and the challenge has been issued. Later, Herod changes the rules and now all fights are to the death. Herod takes down Cantrell, and then scolds the crowd for hiring him. Meantime, Eugene the scum bag is heard upstairs molesting a girl. He comes downstairs and brags about it. Ellen attacks him from behind and the two scream at each other until the challenge is made. though it is pouring outside, The two come out firing and Eugene gets his manhood shot off. The rules have changed and the winner is the last alive. Ellen couldn't finish him off, so she returned to the bar. Eugene comes in and shoots her glass. Then Ellen empties her gun into him.Though Herod tells the Kid to quit, that he has proven his point, the Kid stays in and takes
Question: Who is Redemption's ruthless mayor and former outlaw? | [
"herod"
] | task469-99c8a81785ec48c29bb0792b70fcde55 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Many genetic disorders are caused by mutations in one or a few genes. Others are caused by chromosomal mutations. Some human genetic disorders are X-linked or Y-linked, which means the faulty gene is carried on these sex chromosomes. Other genetic disorders are carried on one of the other 22 pairs of chromosomes; these chromosomes are known as autosomes or autosomal (non-sex) chromosomes. Some genetic disorders are due to new mutations, others can be inherited from your parents. Some genetic disorders are caused by recessive alleles of a single gene on an autosome. An example of autosomal recessive genetic disorders are Tay-Sachs disease and cystic fibrosis. Children with cystic fibrosis have excessively thick mucus in their lungs, which makes it difficult for them to breathe. The inheritance of this recessive allele is the same as any other recessive allele, so a Punnett square can be used to predict the probability that two carriers of the disease will have a child with cystic fibrosis. Recall that carriers have the recessive allele for a trait but do not express the trait. What are the possible genotypes of the offspring in the following table ( Table 1.1)? What are the possible phenotypes? F FF (normal) Ff (carrier) F f f Ff (carrier) ff (affected) According to this Punnett square, two parents that are carriers (Ff ) of the cystic fibrosis gene have a 25% chance of having a child with cystic fibrosis (ff ). The affected child must inherit two recessive alleles. The carrier parents are not affected. Tay-Sachs disease is a severe genetic disorder in which affected children do not live to adulthood, so the gene is not passed from an affected individual. Carriers of the Tay-Sachs gene are not affected. How does a child become affected with Tay-Sachs? Huntingtons disease is an example of an autosomal dominant disorder. This means that if the dominant allele is present, then the person will express the disease. A child only has to inherit one dominant allele to have the disease. The disease causes the brains cells to break down, leading to muscle spasms and personality changes. Unlike most other genetic disorders, the symptoms usually do not become apparent until middle age. You can use a simple Punnett square to predict the inheritance of a dominant autosomal disorder, like Huntingtons disease. If one parent has Huntingtons disease, what is the chance of passing it on to the children? If you draw the Punnett square, you will find that there is a 50 percent chance of the disorder being passed on to the children.
Question: for a child to have cystic fibrosis, the child had to | [
"inherit two recessive alleles."
] | task469-17422480c6c84e75bc011ce16db89870 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: A sexually transmitted infection (STI) is a disease that spreads mainly through sexual contact. STIs are caused by pathogens that enter the body through the reproductive organs. Many STIs also spread through body fluids such as blood. For example, a shared tattoo needle is one way that some STIs can spread. Some STIs can also spread from a mother to her infant during birth. STIs are more common in teens and young adults than in older people. One reason is that young people are more likely to engage in risky behaviors. They also may not know how STIs spread. Instead, they may believe myths about STIs, like those in Table 22.1. Knowing the facts is important to prevent the spread of STIs. Myth If you are sexually active with just one person, then you cant get STIs. If you dont have any symptoms, then you dont have an STI. Getting STIs is no big deal, because they can be cured with medicines. Fact The only sure way to avoid getting STIs is to practice abstinence from sexual activity. Many STIs do not cause symptoms, especially in fe- males. Only some STIs can be cured with medicines; others cannot be cured. A number of STIs are caused by bacteria. Bacterial STIs can usually be cured with antibiotics. However, some people with bacterial STIs may not have symptoms so they fail to get treatment. Left untreated, these infections may damage reproductive organs and lead to an inability to have children. Three bacterial STIs are chlamydia, gonorrhea, and syphilis. Chlamydia is the most common bacterial STI in the U.S. Females are more likely to develop it than males. Symptoms may include burning during urination and a discharge from the vagina or penis. Gonorrhea is another common bacterial STI. Symptoms may include painful urination and a discharge from the vagina or penis. Syphilis is a very serious STI but somewhat less common than chlamydia or gonorrhea. It usually begins with a small sore on the genitals. This is followed a few months later by a rash and flu-like symptoms. If syphilis isnt treated, it can eventually damage the heart, brain, and other organs and even cause death. Several STIs are caused by viruses. Viral STIs cant be cured with antibiotics. Other drugs may help control the symptoms of viral STIs, but the infections usually last for life. Three viral STIs are genital warts, genital herpes, and AIDS. Genital herpes is a common STI caused by a herpes virus. The virus causes painful blisters on the penis or near the vaginal opening. The blisters generally go away on their own, but they may return repeatedly throughout life. There is no cure for genital herpes, but medicines can help prevent or shorten outbreaks. Acquired Immunodeficiency Syndrome (AIDS) is caused by human immunodeficiency virus (HIV). HIV destroys lymphocytes that normally fight infections. AIDS develops if the number of lymphocytes drops to a very low level. People with AIDS come down with diseasessuch as certain rare cancersthat almost never occur in people with a healthy immune system. Medicines can delay the progression of an HIV infection and may prevent AIDS from developing. Genital warts is an STI caused by human papilloma virus (HPV), which is pictured in Figure 22.15. This is one of the most common STIs in U.S. teens. Genital warts cant be cured, but a vaccine can prevent most HPV infections. The vaccine is recommended for boys and girls starting at 11 or 12 years of age. Its important to prevent HPV infections because they may lead to cancer later in life. Other reproductive system disorders include injuries and noninfectious diseases. These are different in males and females. Most common disorders of the male reproductive system involve the testes. They include injuries and cancer. Injuries to the testes are very common. In teens, such injuries occur most often while playing sports. Injuries to the testes are likely to be very painful and cause bruising and swelling. However, they generally subside fairly quickly. Cancer of the testes is most common in males aged 15 to 35. It occurs when cells in the testes grow out of control and form a tumor. If found early
Question: In which of the following age groups are STIs most common? | [
"teens and young adults"
] | task469-dcf5b529c68644d2b9227a4eb94f0bcd | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Rigel Pharmaceuticals Inc is developing fostamatinib, a prodrug of the spleen tyrosine kinase (Syk) inhibitor R-406, for the potential treatment of autoimmune diseases such as rheumatoid arthritis (RA), idiopathic thrombocytopenic purpura (ITP) and B-cell lymphomas. Syk is a key mediator of Fc and B-cell receptor signaling in inflammatory cells, such as B-cells, mast cells, macrophages and neutrophils. Preclinical studies of R-406 or fostamatinib demonstrated a significant reduction in major inflammatory mediators such as TNFalpha, IL-1, IL-6 and IL-18, leading to reduced inflammation and bone degradation in models of RA. In a phase II clinical trial, fostamatinib treatment effectively improved American College of Rheumatology response rates in patients with RA. Preclinical studies and phase II trials also suggested the potential of using fostamatinib for the treatment of ITP and B-cell lymphomas, by increasing platelet counts and inducing response rates, respectively. Fostamatinib is orally bioavailable and was well tolerated in phase I and II trials, with the most common side effect being gastrointestinal symptoms. At the time of publication, phase II trials for fostamatinib were ongoing in patients with RA, ITP and B-cell lymphomas. The Syk inhibitor appears to be a promising therapeutic for immunological diseases, but further data are required to establish the efficacy and long-term safety of the drug in humans.
Question: Which enzyme is inhibited by a drug fostamatinib? | [
"spleen tyrosine kinase"
] | task469-0e8063cfc12a432792c1d3c56dcb9277 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Televisions were among the most talked about items at the 2013 International Consumer Electronics Show last week in Las Vegas, Nevada. Some employed the most advanced technology ever. Some of the TVs used a new technology called Organic Light Emitting Diodes, or OLED. They were thinner, lighter, offered better color1 and were brighter than traditional LEDs. Smart TVs this year were smarter. Many offered technology that let users have a more personalized experience. One such TV from the electronics company TCL uses sensors and voice recognition to determine who is watching. It then offers programming based on the specific user. Another TV from Panasonic offers a similar personalized user experience. In addition to television technology, size also played a major part in CES 2013. Televisions varied in size from big to bigger, with at least two companies -- Samsung and HiSense -- exhibiting TVs measuring 110 inches. The yearly Consumer Electronics Show is the biggest technology trade show in North America and one of the biggest in the world. Gary Shapiro is president and CEO of the Consumer Electronics Association, the group that organizes CES. He gave one of the keynote speeches on opening day. "Now you know that CES is more than a trade show. It's a gathering of the brightest minds and the top leaders from many industries and those seeking a glimpse into the future." That glimpse into the future included a look at digital health and fitness devices, which were also big at CES 2013. There were devices that track your activity and others that measure blood pressure, heart rate and weight. There was even a fork that tells you when you are eating too fast. Cars, smart-phones, tablet computers and PCs also made news. And a 27-inch table computer drew quite a bit of attention. CEA President Gary Shapiro says there was much to see but not nearly enough time to see it all. "You cannot see the show in the four days that you have. We have over 3200 different industries showing over 20,000 new products. It's ly incredible."
Question: At the 2013 CES, which item drew the most attention? | [
"televisions."
] | task469-e1ea0bf834604ceab05a40c6b76e6dbc | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Buoyancy is the ability of a fluid to exert an upward force on any object placed in the fluid. This upward force is called buoyant force. What explains buoyant force? Recall from the earlier lesson "Pressure of Fluids" that a fluid exerts pressure in all directions but the pressure is greater at greater depth. Therefore, the fluid below an object exerts greater force on the object than the fluid above the object. This is illustrated in Figure 15.12. Buoyant force explains why objects may float in water. No doubt youve noticed, however, that some objects do not float in water. If buoyant force applies to all objects in fluids, why do some objects sink instead of float? The answer has to do with their weight. Weight is a measure of the force of gravity pulling down on an object. Buoyant force pushes up on an object. Weight and buoyant force together determine whether an object sinks or floats. This is illustrated in Figure 15.13. If an objects weight is the same as the buoyant force acting on the object, then the object floats. This is the example on the left in Figure 15.13. If an objects weight is greater than the buoyant force acting on the object, then the object sinks. This is the example on the right in Figure 15.13. Because of buoyant force, objects seem lighter in water. You may have noticed this when you went swimming and could easily pick up a friend or sibling under the water. Some of the persons weight was countered by the buoyant force of the water. Density, or the amount of mass in a given volume, is also related to buoyancy. Thats because density affects weight. A given volume of a denser substance is heavier than the same volume of a less dense substance. For example, ice is less dense than liquid water. This explains why ice cubes float in a glass of water. This and other examples of density and buoyant force are illustrated in Figure 15.14 and in the video at this URL: MEDIA Click image to the left or use the URL below. URL: Did you ever notice that when you get into a bathtub of water the level of the water rises? More than 2200 years ago, a Greek mathematician named Archimedes noticed the same thing. He observed that both a body and the water in a tub cant occupy the same space at the same time. As a result, some of the water is displaced, or moved out of the way. How much water is displaced? Archimedes determined that the volume of displaced water equals the volume of the submerged object. So more water is displaced by a bigger body than a smaller one. What does displacement have to do with buoyant force? Everything! Archimedes discovered that the buoyant force acting on an object in a fluid equals the weight of the fluid displaced by the object. This is known as Archimedes law (or Archimedes Principle). Archimedes law explains why some objects float in fluids even though they are very heavy. Remember the oil tanker that opened this chapter? It is extremely heavy, yet it stays afloat. If a steel ball with the same weight as the ship were put into water, it would sink to the bottom (see Figure 15.15). Thats because the volume of water displaced by the steel ball weighs less than the ball. As a result, the buoyant force is not as great as the force of gravity acting on the ball. The design of the ships hull, on the other hand, causes it to displace much more water than the ball. In fact, the weight of the displaced water is greater than the weight of the ship, so the buoyant force is greater than the force of gravity acting on the ship. As a result, the ship floats. You can check your understanding of Archimedes law by doing the brainteaser at this URL: . For an entertaining video presentation of Archimedes law, go to this URL: [Link]
Question: force that causes an object to float on a fluid | [
"buoyant force"
] | task469-ad53821f8b304c01bc4333a8f3085f55 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The 49ers would trail 20-13 with less than a minute to go. Blaine Gabbert would run in a game-tying 44 yard touchdown to tie the game at 20. The Bears appeared to have the game won when they went down the field after a decent kick return by Deonte Thompson for 74 yards. Robbie Gould came out to attempt a game-winning 36 yard field goal, but the kick was wide left, resulting in overtime. In the overtime period, Gabbert would throw the game-winning 71-yard touchdown pass to Torrey Smith to win the game for San Francisco. This was San Francisco's first win in Chicago since the 1989 NFC Championship Game.
Question: Who threw the longest touchdown pass in overtime? | [
"gabbert"
] | task469-fcc9d818c256407386926af26bbe4e2b | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Jaccard index, also known as the Jaccard similarity coefficient (originally coined coefficient de communaute by Paul Jaccard), is a statistic used for comparing the similarity and diversity of sample sets.
Question: Who made Jaccard index known? | [
"paul jaccard"
] | task469-98e56521e08b4c3e9f98e5832b9f4428 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: San Francisco kept Detroit in the game with missed opportunities, then made just enough plays for a rare two-game winning streak and its first road win. RB Frank Gore set a franchise record with 148 yards rushing in the first half and scored on a 61-yard run before leaving with a concussion. San Francisco led 13-3 at halftime after scoring on three of its first four drives, wishing it had a bigger lead after out gaining Detroit 247-102 yards and recovering a fumble without giving up a turnover. The 49ers had chances to go ahead big in the third quarter because Detroit had two turnovers on its first three plays, but they came away with only a field goal and a 13-point lead. Gore then caught a 7-yard pass, wobbled off the field and didn't return. QB Alex Smith's fumble midway through the third quarter set up a score that helped the Lions get back in the game. The 49ers drove down the field to set up K Joe Nedney's fourth field goal, a key score because it made Detroit go for a TD instead of kicking a tying field goal late in the game. S Keith Lewis intercepted QB Jon Kitna's pass at the 49ers' 2 with 2 minutes left and San Francisco now 4-5 picked up the one first down it needed to seal the game, winning consecutive games for the second time since 2003. RB Frank Gore finished with career-high 159 yards rushing and San Francisco's QB Alex Smith was 14 of 20 for 136 yards with a fumble. WR Arnaz Battle caught six passes for 55 yards, and converted a third-and-4 on the final drive to allow the 49ers to run out the clock. The 49ers' defense again came up huge, allowing only 273 total offensive yards and forcing 4 turnovers. LB Brandon Moore was yet again the story, leading the team with 9 tackles, 2 sacks and forcing 2 turnovers. With the win, the 49ers advanced to 4-5.
Question: Which player had a touchdown before halftime? | [
"frank gore"
] | task469-896662b58159491dba7c88dd859b3380 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Phthiriasis palpebrarum is an infestation of the eyelashes caused by the louse Pthirus pubis (Linnaeus, 1758). We report a case of phthiriasis palpebrarum in a 6-year-old girl, which was initially misdiagnosed as allergic blepharoconjunctivitis. Parasites and their nits were found adhering to the eyelashes and eyelids of her right eye as well as scalp hairs. No abnormality was found in the left eye. The histopathology exam revealed the presence of adults and eggs of Pthirus pubis. We mechanically removed all the eyelashes of the right eye at their base, with lice and nits. The scalp was shaved and washed with phenothrin shampoo. No recurrence was found during 3 months of follow-up. Removal of the eyelashes, cutting of scalp hairs, and phenothrin shampoo may be effective in treating phthiriasis palpebrarum. In cases of blepharoconjunctivitis, eyelids and eyelashes should be carefully examined by slit lamp to avoid misdiagnosis.
Question: What is the cause of Phthiriasis Palpebrarum? | [
"pthirus pubis"
] | task469-5bd255760d2743a88c778f42beb3661b | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In 1991, the governments of the U.S. and China are on the verge of a major trade agreement, with the President of the United States due to visit China to seal the deal. The CIA learns that its asset Tom Bishop (Brad Pitt) has been captured trying to free a Briton, Elizabeth Hadley (Catherine McCormack), from a People's Liberation Army prison in Su Chou near Shanghai, China. Bishop is being questioned under torture and will be executed in 24 hours unless the U.S. government claims him. If the CIA claims Bishop as an agent, they risk jeopardizing the trade agreement. Exacerbating Bishop's situation is the fact that he was operating without permission from the Agency. Attempting to deal quickly with the situation, CIA executives call in Nathan Muir (Robert Redford), an aging mid-level case officer on his last day before retirement and the man who recruited Bishop. Although they tell Muir they simply need him to act as a "stop gap" to fill in some holes in their background files, the officials are hoping he will give them the pretext they need to justify letting Bishop die. The CIA executives are unaware that Muir had been tipped off about Bishop's capture prior to arriving at the CIA's headquarters, by fellow CIA veteran Harry Duncan (David Hemmings), for whom Bishop had been working an operation in Hong Kong before going rogue. Muir first attempts to save Bishop by leaking the story to CNN through a contact in Hong Kong, believing that public pressure would force the CIA to rescue Bishop. The tactic only stalls them, however, and is stymied when a phone call to the U.S. Federal Communications Commission from CIA Deputy Director Charles Harker (Stephen Dillane) results in CNN retracting the story. During the debriefing, Muir describes how he recruited Bishop for an operation when Bishop was a U.S. Marine scout sniper during the Vietnam War. Muir also discusses their 1976 tour of duty in Berlin, Germany, where Bishop was tasked with procuring East German assets, with Muir commanding, as well as Bishop's spy work in Beirut, Lebanon in 1985 during the War of the Camps, the latter being the last time the two saw each other. During the mission in Lebanon, Bishop met Hadley, and the two began developing romantic feelings for each other. However, it is revealed that Hadley was involved in a bombing of the Chinese embassy in Britain, causing her to flee the country. Fearing that Bishop's feelings for Hadley might compromise his cover and the mission, Muir tips off the Chinese to Hadley's location in return for freeing an arrested U.S. diplomat. Chinese agents kidnap Hadley, and Bishop cuts all ties to Muir when he discovers his involvement. After learning Hadley was the target of Bishop's rescue attempt, Muir finally realizes that he has greatly underestimated Bishop's feelings for her. Running out of time, Muir secretly creates a forged urgent operational directive from the CIA director to commence Operation Dinner Out, a rescue mission to be spearheaded by Commander Wiley's (Dale Dye) U.S. Navy SEAL team, for which Bishop had laid the groundwork as a "Plan B" for his own rescue attempt. Using US$282,000 of his life savings and a misappropriated file on Chinese coastline satellite imagery, Muir enlists Duncan's help in bribing a Chinese energy official to cut power to the prison for 30 minutes, during which time the SEAL rescue team retrieves Bishop and Hadley. Bishop, who is rescued at the end of the film 15 minutes before his scheduled execution, realizes Muir was behind his rescue when he recognizes the name of the plan to rescue him, Operation Dinner Out: a reference to a birthday gift that Bishop gave Muir while they were in Lebanon. When the CIA officials are belatedly informed of the rescue, Muir has already left the building and is seen driving off into the countryside.
Question: Who arranged the kidnapping? | [
"chinese agents"
] | task469-2f0449e0af3440178b02610e7f75f454 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: James Sangala (born 20 August 1986) is a Malawian international footballer who plays for Angolan club side Primeiro de Agosto, as a defender.
Question: At what position on the field did James Sangala play football? | [
"defender"
] | task469-9a7196088ebc466d84a7b6ade82d69f1 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: American Girl It's packed with the things that matter most to girls: party plans, games, crafts and girl-to-girl advice. American Girlis an appealing, age-appropriate teen magazine that allows young girls to be themselves. The magazine features fun contests, puzzles, giggles, and more! Stories, creative games, cool contests and great sports tips for girls aged 7-11 are available in each issue ofAmerican Girl magazine. Issues per year: 6 Cover price: $ 27.95 Sale price: $22.95 Ladybug Beautiful, colorful, and delightful to read, each issue is filled with charming read-aloud stories, games for memory and skill building, songs, poems, and activities for beginning readers. Parents can visit our online Parents Companion that recommends additional activities, crafts, and books. Issues per year: 9 Cover price: $44.50 Sale price: $33.95 Cicada A monthly magazine for teenagers and young adults aged 14 and up. It offers high-quality fiction and poetry dealing with the issue of growing up, leaving the joys and pains of childhood behind, and becoming an adult. Cicadamagazine also encourages its teen readers to submit their own writing for publication. It's so inspiring and humorous that you will not be able to put it down. Issues per year: 6 Cover price: $51.00 Sale price: $33.95 Sorts Illustrated for Kids It covers sports kids like. Featuring interviews with sports heroes, entertaining comics, breathtaking action photos, tips from the pros , news items of recent notes, games, puzzles, cartoons, fiction, advice from athletes, etc.Sports Illustrated for Kidsis a magazine for children aged 8 and up. Issues per year: 12 Cover price: $47.88 Sale price: $ 24.95
Question: Which of the four magazines is the most suitable for a 4-year-old child? | [
"ladybug."
] | task469-2fbc1022ea474286988e222eb73b1f16 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In 1982, in New Jersey, Gracie (Mary Ashleigh Green) is in a school playground where one boy is bullying another. She steps in and beats up the bully to help the victim, a boy she likes. But instead of being grateful, he feels humiliated at being rescued "by a girl," and gets angry at her. She promptly punches him in the nose and then sulks alone in the playground. Fast-forward to the present day, and Gracie Hart (Sandra Bullock) is an FBI Special Agent. In the middle of an operation against Russian mobsters, the target starts to choke on some food, and Gracie disobeys her superior's command in order to prevent the target from choking. As a result, a member of her squad gets shot, and she is reprimanded by being reassigned to a desk job. Soon afterwards, the bureau learns that there has been a bomb threat against the 75th annual Miss United States beauty pageant in San Antonio, Texas, which the bureau determines came from the notorious domestic terrorist known as "The Citizen". Gracie's partner, Special Agent Eric Matthews (Benjamin Bratt), is chosen to lead the mission to prevent the attack. Despite Eric's position as a lead agent in charge, it is apparent that Gracie is the more capable agent, as Eric is unsure of how to proceed and takes credit for Gracie's suggestions. One of Gracie's suggestions is to put an agent undercover at the pageant. Gracie's male colleagues then proceed to have a bit of fun running the digital images of female and male agents through a website meant for children to play dress up with their dolls. Despite the immature and chauvinistic actions of the agents, Eric recognizes that Gracie is the female FBI agent best qualified for the undercover job. Beauty pageant coach Victor Melling (Michael Caine), whose reputation was ruined after his last contestant criticized his methods, teaches the tomboyish Gracie how to dress, walk, and act like a contestant. She is not used to such behavior, however, and sees the pageant and its participants as "antifeminist ". Eventually though Victor and Gracie come to respect each other's strengths. Representing New Jersey as "Gracie Lou Freebush", Gracie impresses the audience by playing the glass harp and demonstrating self-defense techniques during the talent competition. She also unexpectedly becomes friends with the other contestants, in particular Miss Rhode Island, Cheryl Frasier (Heather Burns) Several suspects emerge, including the corrupt competition director and former pageant winner Kathy Morningside (Candice Bergen); her unpleasant assistant Frank Tobin (Steve Monroe); the veteran pageant MC Stan Fields (William Shatner) who, like Kathy, is being replaced with a younger person; and last but not least Cheryl, who appears to have a history as a radical animal rights activist. While Gracie takes Cheryl and some of the other girls out partying, in an attempt to seek out more information about Cheryl's past through "girl talk", The Citizen is arrested elsewhere on an unrelated charge. After hearing what some of the other contestants said about Kathy Morningside's past (she won the pageant only after the original winner "mysteriously" contracted food poisoning), Gracie begins to suspect her, and is worried about the safety of the girls. Her boss thinks that her suspicions are groundless and that the pageant is out of danger now that the Citizen has been arrested. He calls off the mission. Gracie opts to turn in her badge and gun and continue the investigation alone. Eric initially fails to support Gracie and is about to return to the bureau when he figures out that Gracie's suspicions must be correct, and returns to help her. In the final round of the pageant, Gracie earns 1st Runner up while Cheryl becomes Miss United States. Gracie realizes that Kathy Morningside and Frank Tobin unknown to anyone (except Victor) is Kathy's son impersonated "The Citizen" and made the threat. Because she was going to be fired after the pageant was over, Kathy and her son were planning to murder the newly crowned pageant winner on stage by putting an explosive device in her
Question: Where does Gracie Hart sulk? | [
"the playground"
] | task469-698647c9ad8f4def90ce68ac570f9105 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Egyptian Peasant is a book by Henry Habib Ayrout about the life of the Egyptian peasant (fellah).
Question: Who was the writer of The Egyptian Peasant? | [
"henry habib ayrout"
] | task469-2f540d17520a443288f2856775438b61 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Coming off their last-second victory over the Bengals, the Broncos would play their Week 2 home opener against the Cleveland Browns. In the first quarter, Denver would trail early as Browns kicker Phil Dawson got a 22-yard field goal. Afterwards, the Broncos took the lead as quarterback Kyle Orton completed a 2-yard touchdown pass to tight end Tony Scheffler. Cleveland would creep close as Dawson made a 47-yard field goal, but Denver would answer as kicker Matt Prater got a 23-yard field goal in the second quarter and a 38-yard field goal in the third quarter. In the fourth, the Broncos pulled away as fullback Peyton Hillis got a 2-yard touchdown run and running back Correll Buckhalter got a 45-yard touchdown run.
Question: Which player kicked the second most longest field goal? | [
"matt prater"
] | task469-10e5e32fe73d4c659b5b6cf174682c76 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The RTS,S/AS01(E) candidate malaria vaccine is being developed for immunisation of infants in Africa through the expanded programme on immunisation (EPI). 8 month follow-up data have been reported for safety and immunogenicity of RTS,S/AS01(E) when integrated into the EPI. We report extended follow-up to 19 months, including efficacy results. We did a randomised, open-label, phase 2 trial of safety and efficacy of the RTS,S/AS01(E) candidate malaria vaccine given with EPI vaccines between April 30, 2007, and Oct 7, 2009, in Ghana, Tanzania, and Gabon. Eligible children were 6-10 weeks of age at first vaccination, without serious acute or chronic illness. All children received the EPI diphtheria, tetanus, pertussis (inactivated whole-cell), and hepatitis-B vaccines, Haemophilus influenzae type b vaccine, and oral polio vaccine at study months 0, 1, and 2, and measles vaccine and yellow fever vaccines at study month 7. Participants were randomly assigned (1:1:1) to receive three doses of RTS,S/AS01(E) at 6, 10, and 14 weeks (0, 1, 2 month schedule) or at 6 weeks, 10 weeks, and 9 months (0, 2, 7 month schedule) or placebo. Randomisation was according to a predefined block list with a computer-generated randomisation code. Detection of serious adverse events and malaria was by passive case detection. Antibodies against Plasmodium falciparum circumsporozoite protein and HBsAg were monitored for 19 months. This study is registered with ClinicalTrials.gov, number NCT00436007. 511 children were enrolled. Serious adverse events occurred in 57 participants in the RTS,S/AS01(E) 0, 1, 2 month group (34%, 95% CI 27-41), 47 in the 0, 1, 7 month group (28%, 21-35), and 49 (29%, 22-36) in the control group; none were judged to be related to study vaccination. At month 19, anticircumsporozoite immune responses were significantly higher in the RTS,S/AS01(E) groups than in the control group. Vaccine efficacy for the 0, 1, 2 month schedule (2 weeks after dose three to month 19, site-adjusted according-to-protocol analysis) was 53% (95% CI 26-70; p=00012) against first malaria episodes and 59% (36-74; p=00001) against all malaria episodes. For the entire study period, (total vaccinated cohort) vaccine efficacy against all malaria episodes was higher with the 0, 1, 2 month schedule (57%, 95% CI 33-73; p=00002) than with the 0, 1, 7 month schedule (32% CI 16-45; p=00003). 1 year after dose three, vaccine efficacy against first malaria episodes was similar for both schedules (0, 1, 2 month group, 616% [95% CI 356-771], p<0001; 0, 1, 7 month group, 638% [404-780], p<0001, according-to-protocol cohort). Vaccine efficacy was consistent with the target put forward by the WHO-sponsored malaria vaccine technology roadmap for a first-generation malaria vaccine. The 0, 1, 2 month vaccine schedule has been selected for phase 3 candidate vaccine assessment. Program for Appropriate Technology in Health Malaria Vaccine Initiative; GlaxoSmithKline Biologicals.
Question: RTS S AS01 vaccine was developed to prevent which disease? | [
"malaria"
] | task469-9fa1d2cb47594f4e85113d31af9f6de4 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: DNA and RNA are nucleic acids. DNA stores genetic information. RNA helps build proteins. Proteins, in turn, determine the structure and function of all your cells. Proteins consist of chains of amino acids. A proteins structure and function depends on the sequence of its amino acids. Instructions for this sequence are encoded in DNA. In eukaryotic cells, chromosomes are contained within the nucleus. But proteins are made in the cytoplasm at structures called ribosomes. How do the instructions in DNA reach the ribosomes in the cytoplasm? RNA is needed for this task. RNA stands for ribonucleic acid. RNA is smaller than DNA. It can squeeze through pores in the membrane that encloses the nucleus. It copies instructions in DNA and carries them to a ribosome in the cytoplasm. Then it helps build the protein. RNA is not only smaller than DNA. It differs from DNA in other ways as well. It consists of one nucleotide chain rather than two chains as in DNA. It also contains the nitrogen base uracil (U) instead of thymine (T). In addition, it contains the sugar ribose instead of deoxyribose. You can see these differences in Figure 5.16. There are three different types of RNA. All three types are needed to make proteins. Messenger RNA (mRNA) copies genetic instructions from DNA in the nucleus. Then it carries the instructions to a ribosome in the cytoplasm. Ribosomal RNA (rRNA) helps form a ribosome. This is where the protein is made. Transfer RNA (tRNA) brings amino acids to the ribosome. The amino acids are then joined together to make the protein. How is the information for making proteins encoded in DNA? The answer is the genetic code. The genetic code is based on the sequence of nitrogen bases in DNA. The four bases make up the letters of the code. Groups of three bases each make up code words. These three-letter code words are called codons. Each codon stands for one amino acid or else for a start or stop signal. There are 20 amino acids that make up proteins. With three bases per codon, there are 64 possible codons. This is more than enough to code for the 20 amino acids plus start and stop signals. You can see how to translate the genetic code in Figure 5.17. Start at the center of the chart for the first base of each three-base codon. Then work your way out from the center for the second and third bases. Find the codon AUG in Figure 5.17. It codes for the amino acid methionine. It also codes for the start signal. After an AUG start codon, the next three letters are read as the second codon. The next three letters after that are read as the third codon, and so on. You can see how this works in Figure 5.18. The figure shows the bases in a molecule The genetic code has three other important characteristics. The genetic code is the same in all living things. This shows that all organisms are related by descent from a common ancestor. Each codon codes for just one amino acid (or start or stop). This is necessary so the correct amino acid is always selected. Most amino acids are encoded by more than one codon. This is helpful. It reduces the risk of the wrong amino acid being selected if there is a mistake in the code. The process in which proteins are made is called protein synthesis. It occurs in two main steps. The steps are transcription and translation. Watch this video for a good introduction to both steps of protein synthesis: [Link] MEDIA Click image to the left or use the URL below. URL: Transcription is the first step in protein synthesis. It takes place in the nucleus. During transcription, a strand of DNA is copied to make a strand of mRNA. How does this happen? It occurs by the following steps, as shown in Figure 5.19. 1. An enzyme binds to the DNA. It signals the DNA to unwind. 2. After the DNA unwinds, the enzyme can read the bases in one of the DNA strands. 3. Using this strand of DNA as
Question: _____type of RNA that copies DNA in the nucleus | [
"mrna"
] | task469-3aeaaadbee8b43aeb0b2d27684acd3a6 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Energy travels through space or material. This is obvious when you stand near a fire and feel its warmth or when you pick up the handle of a metal pot even though the handle is not sitting directly on the hot stove. Invisible energy waves can travel through air, glass, and even the vacuum of outer space. These waves have electrical and magnetic properties, so they are called electromagnetic waves. The transfer of energy from one object to another through electromagnetic waves is known as radiation. Different wavelengths of energy create different types of electromagnetic waves (Figure 1.1). The wavelengths humans can see are known as visible light. When viewed together, all of the wavelengths of visible light appear white. But a prism or water droplets can break the white light into different wavelengths so that separate colors appear (Figure 1.2). What objects can you think of that radiate visible light? Two include the Sun and a light bulb. The longest wavelengths of visible light appear red. Infrared wavelengths are longer than visible red. Snakes can see infrared energy. We feel infrared energy as heat. Wavelengths that are shorter than violet are called ultraviolet. Can you think of some objects that appear to radiate visible light, but actually do not? The Moon and the planets do not emit light of their own; they reflect the light of the Sun. Reflection is when light (or another wave) bounces back from a surface. Albedo is a measure of how well a surface reflects light. A surface with high albedo reflects a large percentage of light. A snow field has high albedo. One important fact to remember is that energy cannot be created or destroyed it can only be changed from one form to another. This is such a fundamental fact of nature that it is a law: the law of conservation of energy. In photosynthesis, for example, plants convert solar energy into chemical energy that they can use. They do not create new energy. When energy is transformed, some nearly always becomes heat. Heat transfers between materials easily, from warmer objects to cooler ones. If no more heat is added, eventually all of a material will reach the same temperature.
Question: this breaks up light into different wavelengths, separating light into different colors. | [
"prism"
] | task469-45778655f7d94af39f025359c0ebc049 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The film Calvary is a parable of the betrayal of the Irish people by the Irish Catholic Church.Context for the story: The Irish Catholic Church which was a pillar of, and defined Ireland's soul has been revealed to have consciously and methodically covered up institutional atrocities perpetrated by themselves.Set in rural Ireland, the film begins in a confessional where Father James Lavelle (Brendan Gleeson) is taking confession. The voice on the other side speaks, "I was seven the first time I tasted semen". "Certainly a startling opening line", Father James replies. The voice asks if he's being ironic. Father James takes a more serious tone. The voice tells him that he was molested both orally and anally by a priest when he was seven and he bled a lot. Father James asks if he would like to report the priest. The voice says that the priest died a long time ago and that it didn't matter. "Killing a bad priest isn't a big deal, but if you kill a good priest, people take notice". The voice says he's going to kill Father James in seven days on the beach.James lives a very simple life. He sleeps in a small room with a bed and his only two possessions are his crucifix and his dog. He takes walks on the beach and interacts with the town people. On the beach, he sees his altar server is drawing a landscape. In it there are two figures. James asks who they are and the boy says he doesn't know, but he has been having a lot of dreams about ghosts lately.After mass, Father James is speaking with Father Leary (David Wilmot) who is gossiping about the townsfolk, sharing information he's heard in confession and making racially inappropriate comments about Simon (Isaach De Bankole) the only black man in the town. Father James doesn't say a word about the threat on his life.James' daughter Fiona (Kelly Reilly) comes to town to lay low after a botched suicide attempt. The townsfolk didn't know it was possible for a Catholic priest to have a daughter. James explains that he became a priest after his wife died. The locals in the pub try to flirt with Fiona, but she has no interest. James does not drink. Its not because he doesn't like alcohol. Its because he likes it too much.Later in the day, James visits with Veronica Brennan (Orla ORourke) who was wearing sunglasses during mass to cover up her black eye. She says her husband did it. So James goes to meet her husband, the local butcher Jack Brennan (Chris O'Dowd) and confronts him. Jack is surprised, but good natured about the whole thing. He dismisses his wife by saying she's probably bi-polar. He says it wasn't him, but it might have been her boyfriend Simon. James questions the infidelity, but Jack explains that it works for them. They each do their own thing. James meets with Simon, who takes offense to the charge and passively threatens James and tells him to mind his own business.James spends time with an elderly man known only as The Writer (M. Emmet Walsh) who asks for a Walther PPK, James Bonds favorite gun and the gun Hitler used to kill himself. The Writer explains that he doesn't want to get old and feeble. He'd rather just take his own life when the time is right.James meets with the local Bishop and tells him about the threat during the confession. He also reveals that he knows who the man is and believes the threat is real. The Bishop says that because the man didn't ask for repentance and there was the threat of a law being broken, James would not violate and church law in speaking with the police.James goes to speak with his friend Inspector Stanton (Gary Lydon), who seems to be spending some time with a male prostitute named Leo (Owen Sharpe). Leo keeps making lewd advances on James and offers to have sex with him in his vestments because he knows that's what priests like. Eventually Leo leaves and
Question: Whom does Fiona makes peace with? | [
"she makes peace with james.",
"jack"
] | task469-52add92098ae463b94a93aa53d59813e | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Sotos syndrome is an overgrowth syndrome with characteristic facial gestalt and mental retardation of variable severity. Haploinsufficiency of the NSD1 gene has been implicated as the major cause of Sotos syndrome, with a predominance of microdeletions reported in Japanese patients. This study was conducted to investigate into the spectrum of NSD1 gene mutations in southern Chinese patients with Sotos syndrome. Thirty-six Chinese patients with Sotos syndrome and two patients with Weaver syndrome were subject to molecular testing. NSD1 gene mutations were detected in 26 (72%) Sotos patients. Microdeletion was found in only 3 patients, while the other 23 had point mutations (6 frameshift, 8 nonsense, 2 spice site, and 7 missense). Of these, 19 mutations were never reported. NSD1 gene mutations were not found in the two patients with Weaver syndrome. Most cases of Sotos syndrome are caused by NSD1 gene defects, but the spectrum of mutations is different from that of Japanese patients. Genotype-phenotype correlation showed that patients with microdeletions might be more prone to congenital heart disease but less likely to have somatic overgrowth. The two patients with Weaver syndrome were not found to have NSD1 gene mutations, but the number was too small for any conclusion to be drawn.
Question: Which gene is responsible for the development of Sotos syndrome? | [
"nsd1 gene"
] | task469-b5c31d9c218e47d283d82024042e56bb | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Redskins scored the first points of the game when Shaun Suisham kicked a 31-yard field goal in the second quarter. On the last play of the 1st half, Trent Green threw a 1-yard pass to Justin Peelle to claim the lead. The Redskins started the third quarter with Clinton Portis running for a 19-yard touchdown. Miami later answered with a field goal to tie the game. In the 4th quarter, both teams scored a field goal and the game went into overtime. Washington won the coin toss. They ran the ball down to Miami's 22-yardline, and Shaun Suisham made a game-winning 39-yard field goal. Clinton Portis finished the game with 17 carries, 98 yards, and a touchdown. The Redskins lost right tackle Jon Jansen for the year when he fractured his ankle in the second quarter. GameBook
Question: Which team won the coin toss? | [
"the redskins"
] | task469-b59f48afdc9f462390b0d7e533a0151b | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The earth is not the only body that travels around the sun. With it are eight other planets, fellow members of the sun's family. Two of them, Mercury and Venus, are nearer while the other six, namely Mars, Jupiter, Saturn, Uranus, Neptune and Pluto, also in their given order from the sun, are farther from the sun than the earth is. The farther they are, the longer trips they make around the sun. People noticed long ago that these traveling bodies moved around in the sky in definite paths. It is a force called gravity that holds them in their paths. We know that every little bit of matter in the universe pulls upon every other bit of matter. The pull between two bodies is proportional to the product of their masses. Because the sun is so large the pull between the sun and the planets are thus great. If it were not for this pull, the planets would fly off into space. In the same way there exists a pull between the earth and the moon, which keeps the moon traveling in its orbit around our planet, the earth. Gravity holds you to its surface, and pulls back to it the ball which you throw into the air. Of course the ball also pulls on the larger earth but the earth is so much larger that the pull is not noticed. Now remember that large bodies exert a greater pull than smaller ones which contain less material. But each object in the universe, no matter how small, pulls on all other objects to some degree.
Question: Which two planets make the longest trips around the sun among all the planets in the solar system? | [
"neptune and pluto."
] | task469-2a5d9ea3f5534fa9a392a954337b346e | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The major protein constituent of Lewy bodies (LBs), the pathological hallmark of Parkinson disease and dementia with Lewy bodies, is considered to be alpha-synuclein, but other proteins, in particular the microtubule-associated protein tau, have been implicated in the pathogenesis of LBs. Tau is the major structural component of neurofibrillary tangles (NFTs). Both direct immunochemical studies of partially purified LBs and indirect immunohistochemical studies have suggested that LBs may contain tau, but most of these studies were based upon a single tau antibody, and immunologic cross-reactivity was not completely excluded. To gain insight into the relation between tau and alpha-synuclein in LBs, double immunostaining was performed in Lewy body cases with a rabbit polyclonal antibody to alpha-synuclein and a panel of monoclonal antibodies to phospho- and nonphospho-tau epitopes (Alz50, CP9, CP13, PG5, TG3, PHFI) that spanned the length of the tau molecule. Tau-immunoreactive LBs were present in the medulla in 80% of the cases, irrespective of Braak stage. All tau antibodies recognized at least some LBs, arguing against nonspecific antibody cross-reactivity. In most lesions the tau immunostaining was present at the periphery of the LB. The phospho-tau antibody, TG3, detected more LBs than any of the other tau antibodies. The proportion of LBs with tau immunoreactivity was greatest in neurons vulnerable to NETs, such as those in the locus ceruleus and basal nucleus of Meynert, and least in neurons resistant to NFTs, such as the dorsal motor nucleus of the vagus in the medulla. The present results suggest that tau may coaggregate with alpha-synuclein in LBs, especially in neuronal populations vulnerable to both NFTs and LBs.
Question: Which is the primary protein component of Lewy bodies? | [
"αsyn",
"α-synuclein",
"alpha-synuclein"
] | task469-b21a941b2e9f4b8d9e164985b3e1f2c5 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Set in the Australian outback in the 1880s, the movie follows the series of events following the horrific rape and murder of the Hopkins family, allegedly committed by the infamous Burns brothers gang.The film opens in a brothel during a violent gunfight between the police and Charlie Burns' (Guy Pearce) gang, which ends with the deaths of all of the gang members except for Charlie and his younger brother Mikey. Captain Stanley (Ray Winstone) proposes to Charlie: he and Mikey can go free of the crimes they have committed if Charlie kills his older brother, Arthur (Danny Huston). Arthur is a mercurial psychopath who has become something of a legend and is so vicious that the Aboriginal tribes refer to him as "The Dog Man" and both the police and the Aboriginals refuse to go near his camp. Captain Stanley muses that perhaps the bounty hunters will kill Arthur in time and then states his intention to civilize the harsh Australian wilderness by bringing Arthur to justice and using Mikey as leverage. Charlie has nine days to find and kill Arthur, or else Mikey will be hanged from the gallows on Christmas Day.We discover why Captain Stanley is intent on taming Australia: he has been forced to move there with his delicate wife, Martha Stanley (Emily Watson), and apparently wants to make it an appropriate place for them to live. The Stanleys were also friends of the Hopkins family, leading Martha to have nightmares about her dead friends and the unborn child one of them is revealed to have carried. Word spreads of Stanley's deal with Charlie, primarily from Stanley's corrupt subordinate, Sergeant Lawrence (Robert Morgan), causing disgust among the townspeople.Shortly thereafter, Eden Fletcher (David Wenham), for whom Captain Stanley works, orders that Mikey be given one hundred lashes as punishment for the rape and murder of the Hopkins family. Stanley is aghast at this, not only because he believes that Mikey is innocent and the flogging will surely kill him, but because it would also break his deal with Charlie and thus put him and his wife in grave danger. Stanley sends Sergeant Lawrence away with tracker Jacko (David Gulpillil) and other men to "investigate" the reported slaying of Dan O'Riley by a group of Aborigines. Captain Stanley attempts to defend Mikey by gunpoint from the bloodthirsty townspeople, but is overruled once Martha arrives, insisting on revenge for her dead friends. Mikey is then brutally flogged, and horrifically wounded. The formerly excited townspeople slowly become disgusted and Martha faints at the ghastly display. After 40 lashes, Mikey has collapsed and the whip is soaked with blood. Captain Stanley grabs the whip and throws it at Fletcher, staining his face and suit with blood, who in turn fires Stanley.Meanwhile, Charlie rides a great distance in search of Arthur, drinking and apparently reflecting on what he will do. Along the way, he encounters an inebriated old man named Jellon Lamb (John Hurt). In the course of conversation, Charlie realizes that Lamb is a bounty hunter in pursuit of the Burns brothers and knocks him out. Later on, after sleeping on a rock bed, Charlie awakes and, before he can gather what's going on, is speared in the chest by a group of Aboriginal men standing over him. Seconds later a gunshot is heard and the head of the man who threw the spear explodes. Charlie then passes out.Charlie wakes up in the camp of his brother Arthur, which is located in caves among desolate mountains. Arthur's gang consists of Samuel Stoat (Tom Budge), who shot the Aboriginal man who had speared Charlie; a woman named Queenie (Leah Purcell) who tends to Charlie's wound; and a muscular Aboriginal man called Two-Bob (Tom E. Lewis). As he recovers from his wounds, Charlie has several opportunities to kill his brother, but does not. Not too far away from Arthur's camp, Sergeant Lawrence and his men have found and butchered a group of Aborigines. Arthur and Two-Bob find Lawrence's group while they sleep, ostensibly to get a horse for Charlie, and proceed to kill Jacko and Sergeant Lawrence. Before Arthur stomps Lawrence
Question: Who is a bounty hunter? | [
"lamb"
] | task469-172387fbe13341eeb037771937b5732f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Born in Belfast, Northern Ireland, the son of Thomas Megahey (a minister) and Beatrice (nee Walton), Leslie Megahey was educated at King Edward VI School in Lichfield.
Question: Which college or university is related with Leslie Megahey? | [
"king edward vi school"
] | task469-41761264a6fe4ce9ab5013169cf55fdd | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Scores of people queued up to use a cash machine after it started giving out double the money requested. The cash machine, outside a Sainsbury's store in Barham Road, Hull, attracted a big crowd of people hoping to take advantage of the fault, on Tuesday night. Police officers were eventually sent in to guard the machine and prevent anymore money from being withdrawn. The fault is thought to have affected cash machines at supermarkets across the city. It is not yet known whether the customers will have to repay the cash or how much money was taken out. A spokeswoman for Humberside Police said, "Officers were sent to the cash machine to prevent anyone else from withdrawing anymore money. We have also tried to make contact with the owners of the machine." The spokeswoman said those who benefited from the fault could be traced and could face theft charges, but investigations would only take place if the operator made a complaint. The cash machine is owned by a company called Payzone, a spokesman later confirmed. He said the fault was due to the machine being filled with notes of the wrong denomination . An investigation is underway into the incident and the machine had been taken out of service, he added. The Payzone spokesman said, "The transit company which is contracted to service this ATM has filled it up with the wrong denomination of notes, meaning it is paying out double what it should have. " He could not say how much money had been taken out of the machine, or whether it would have to be paid back. It was understood that a number of cash machines in Hull owned by other companies had also been affected by this problem, he added.
Question: Who caused the cash machine not to work properly? | [
"the transit company."
] | task469-11b6f4d47d894550b2a5bcae368362dc | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Activation of the non-phagocytic superoxide-producing NADPH oxidase Nox1, complexed with p22(phox) at the membrane, requires its regulatory soluble proteins Noxo1 and Noxa1. However, the role of the small GTPase Rac remained to be clarified. Here we show that Rac directly participates in Nox1 activation via interacting with Noxa1. Electropermeabilized HeLa cells, ectopically expressing Nox1, Noxo1, and Noxa1, produce superoxide in a GTP-dependent manner, which is abrogated by expression of a mutant Noxa1(R103E), defective in Rac binding. Superoxide production in Nox1-expressing HeLa and Caco-2 cells is decreased by depletion or sequestration of Rac; on the other hand, it is enhanced by expression of the constitutively active Rac1(Q61L), but not by that of a mutant Rac1 with the A27K substitution, deficient in binding to Noxa1. We also demonstrate that Nox1 activation requires membrane recruitment of Noxa1, which is normally mediated via Noxa1 binding to Noxo1, a protein tethered to the Nox1 partner p22(phox): the Noxa1-Noxo1 and Noxo1-p22(phox) interactions are both essential for Nox1 activity. Rac likely facilitates the membrane localization of Noxa1: although Noxa1(W436R), defective in Noxo1 binding, neither associates with the membrane nor activates Nox1, the effects of the W436R substitution are restored by expression of Rac1(Q61L). The Rac-Noxa1 interaction also serves at a step different from the Noxa1 localization, because the binding-defective Noxa1(R103E), albeit targeted to the membrane, does not support superoxide production by Nox1. Furthermore, a mutant Noxa1 carrying the substitution of Ala for Val-205 in the activation domain, which is expected to undergo a conformational change upon Rac binding, fully localizes to the membrane but fails to activate Nox1.
Question: Which NADPH oxidase family member requires interaction with NOXO1 for function? | [
"nadph oxidase 1",
"nicotinamide adenine dinucleotide phosphate-oxidase 1",
"nox1"
] | task469-b19dfb857ec0423680ccc9c2a49c69ef | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Lynd was one of two children born to the renowned sociologists Robert Staughton Lynd and Helen Lynd, who authored the groundbreaking ''Middletown'' studies of Muncie, Indiana, in the late 1920s and '30s.
Question: Which lady Staughton Lynd was born to? | [
"helen lynd"
] | task469-fdbee81e41434ee6984a43547353ed3e | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: An ionic bond is the force of attraction that holds together positive and negative ions. It forms when atoms of a metallic element give up electrons to atoms of a nonmetallic element. Figure 7.3 shows how this happens. In row 1 of Figure 7.3, an atom of sodium donates an electron to an atom of chlorine (Cl). By losing an electron, the sodium atom becomes a sodium ion. It now has one less electron than protons, giving it a charge of +1. Positive ions such as sodium are given the same name as the element. The chemical symbol has a plus sign to distinguish the ion from an atom of the element. The symbol for a sodium ion is Na+ . By gaining an electron, the chlorine atom becomes a chloride ion. It now has one more electron than protons, giving it a charge of -1. Negative ions are named by adding the suffix ide to the first part of the element name. The symbol for chloride is Cl . Sodium and chloride ions have equal but opposite charges. Opposites attract, so sodium and chloride ions attract each other. They cling together in a strong ionic bond. You can see this in row 2 of Figure 7.3. Brackets separate the ions in the diagram to show that the ions in the compound do not share electrons. You can see animations of sodium chloride forming at these URLs: [Link]~acarpi/NSC/salt.htm Ionic bonds form only between metals and nonmetals. Metals "want" to give up electrons, and nonmetals "want" to gain electrons. Find sodium (Na) in Figure 7.4. Sodium is an alkali metal in group 1. Like other group 1 elements, it has just one valence electron. If sodium loses that one electron, it will have a full outer energy level. Now find fluorine (F) in Figure 7.4. Fluorine is a halogen in group 17. It has seven valence electrons. If fluorine gains one electron, it will have a full outer energy level. After sodium gives up its valence electron to fluorine, both atoms have a more stable arrangement of electrons. It takes energy to remove valence electrons from an atom. The force of attraction between the negative electrons and positive nucleus must be overcome. The amount of energy needed depends on the element. Less energy is needed to remove just one or a few electrons than many. This explains why sodium and other alkali metals form positive ions so easily. Less energy is also needed to remove electrons from larger atoms in the same group. For example, in group 1, it takes less energy to remove an electron from francium (Fr) at the bottom of the group than from lithium (Li) at the top of the group (see Figure 7.4). In bigger atoms, valence electrons are farther from the nucleus. As a result, the force of attraction between the electrons and nucleus is weaker. What happens when an atom gains an electron and becomes a negative ion? Energy is released. Halogens release the most energy when they form ions. As a result, they are very reactive. Ionic compounds contain ions of metals and nonmetals held together by ionic bonds. Ionic compounds do not form molecules. Instead, many positive and negative ions bond together to form a structure called a crystal. You can see an example of a crystal in Figure 7.5. It shows the ionic compound sodium chloride. Positive sodium ions (Na+ ) alternate with negative chloride ions (Cl ). The oppositely charged ions are strongly attracted to each other. Helpful Hints Naming Ionic Compounds Ionic compounds are named for their positive and negative ions. The name of the positive The crystal structure of ionic compounds is strong and rigid. It takes a lot of energy to break all those strong ionic bonds. As a result, ionic compounds are solids with high melting and boiling points (see Table 7.2). The rigid crystals are brittle and more likely to break than bend when struck. As a result, ionic crystals tend to shatter. You can learn more about the properties of ionic compounds by watching the video at this URL: MEDIA Click image to the left or use the URL below. URL:
Question: example of an alkali metal | [
"sodium"
] | task469-e3aa34d69953456d9c688b6aa03a0af7 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Chaperone-mediated autophagy (CMA) is a selective autophagy-lysosome protein degradation pathway. The role of CMA in normal neuronal functions and in neural disease pathogenesis remains unclear, in part because there is no available method to monitor CMA activity at the single-cell level. We sought to establish a single-cell monitoring method by visualizing translocation of CMA substrates from the cytosol to lysosomes using the HaloTag (HT) system. GAPDH, a CMA substrate, was fused to HT (GAPDH-HT); this protein accumulated in the lysosomes of HeLa cells and cultured cerebellar Purkinje cells (PCs) after labeling with fluorescent dye-conjugated HT ligand. Lysosomal accumulation was enhanced by treatments that activate CMA and prevented by siRNA-mediated knockdown of LAMP2A, a lysosomal receptor for CMA, and by treatments that inactivate CMA. These results suggest that lysosomal accumulation of GAPDH-HT reflects CMA activity. Using this method, we revealed that mutant PKC, which causes spinocerebellar ataxia type 14, decreased CMA activity in cultured PCs. In the present study, we established a novel fluorescent-based method to evaluate CMA activity in a single neuron. This novel method should be useful and valuable for evaluating the role of CMA in various neuronal functions and neural disease pathogenesis.
Question: Which is the receptor for substrates of Chaperone Mediated Autophagy? | [
"lamp2a",
"lysosome-associated membrane protein 2 isoform a"
] | task469-ad5c1f497db44941a37624995063bbdd | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: (Because the film has a very complicated plot and features many characters, the events will be told mostly in chronological order to render the plot clearer, rather than strictly adhering to the order we see in the film.)General Sternwood has two daughters: the elder one is Vivian (Lauren Bacall) and the younger one is Carmen, who is a carefree, childish and problematic young woman.General Sternwood has a man named Sean Regan working for him. With the help of Sean, the general has made a man named Joe Brody leave Carmen alone, by giving him 5.000 Dollars.Carmen loves Sean but Sean loves the wife of a man named Eddie Mars, so he refuses Carmens advances. One day, Carmen kills Sean when she is drunk because of her unrequited love. Eddie hides Seans body. He then makes up the story that Sean and his wife have run away together and nobody sees Sean after that day. To support this story, he actually makes his own wife go away and start living in a remote place. Even the general doesnt know Seans whereabouts and wonders why he has left all of a sudden. Eddie then proceeds to blackmail Vivian for Carmens murder. As a way of eliciting money from Vivian, Eddie makes her win big money at his gambling house with cheats, and then he takes all the money from her.Carmens troublesome adventures are not over, though. A man named Arthur Gwynn Geiger blackmails General Sternwood to take the gambling debts of Carmen. The general hires Philip Marlowe (Humphrey Bogart) to get rid of Geigers blackmail. Vivian talks to Marlowe, thinking that her father has actually hired him to find Sean Regan. Afraid that Carmen may get into trouble, she tries to take words from Marlowes mouth about his inquiry. But she learns that her father has not actually hired Marlowe about Sean.Marlowe goes to Geigers so-called antique books shop and sees a woman named Agnes, who makes it impossible for him to talk to Geiger. Then Marlowe waits at the bookshop across the street until the evening and follows Geiger and his right arm Carol Lundgren to Geigers house. Before Marlowe gets in the house, however, important things happen. Owen Taylor, driver for the Sternwoods, is in love with Carmen. He goes to Geigers house with her and kills Geiger for her. A secret camera, however, takes Carmens photo just at the moment of the murder. Owen then takes the film from the hidden camera, gets in the car and goes away. Joe Brody, also present that night, follows Owen, takes the film from him to blackmail Carmen, (and most probably) kills Owen and pushes his car in the water.When Marlowe gets in Geigers house, he sees Carmen with the dead body of Gaiger lying on the ground. Marlowe takes Carmen home and tells Vivian to say that Carmen has been home all night if asked by anyone. When he goes back to Geigers house, he sees that his dead body has been taken away.Later, Owens dead body is found in the car in the water. He has been killed before falling into the water. Marlowe learns from Vivian that Owen was interested in Carmen. Vivian then tells Marlowe that somebody is blackmailing her for Carmens photo taken at the night of Geigers murder. The blackmailer, who wants 5.000 Dollars, is actually Agnes. It is Joe Brody that makes her blackmail Vivian. Vivian tells Marlowe that she can take the money from Eddie.When Marlowe meets with Carmen once again at Geigers house, she tells him that it was Joe who took her photo that night. Eddie comes along and tries to scare Marlowe out of his inquiries.Later, Marlowe finds Joe Brody and questions him about Geiger. Agnes and Vivian are also at his house. Carmen comes along with a gun and threatens to kill Joe if he doesnt give her the photo. Carmen takes the photo and she leaves with Vivian. Then the doorbell rings again and somebody kills Joe, then escapes. Marlowe catches the man, who turns out to be Carol (Geigers right arm), who thinks that it was Joe who killed Geiger. Marlowe and Carol then go to
Question: Who was at Geiger's house when Marlowe returned to Geiger's house? | [
"carmen"
] | task469-6b7ca3cdd78c4fc3997c25a89f98346e | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
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