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Context: The film opens with an animated prologue revealing the origins of leprechauns, stating that they were summoned by a king to protect his gold from those who would try to steal it. After the death of the king the Leprechauns returned to their places of origin, all except one (Warwick Davis) who remained in the mortal world and through the ages slowly became corrupted and obsessed with the treasure he still guarded. In the present Father Jacob (Willie C. Carpenter) is chased through the construction site of the youth center he had planned on building by the Leprechaun, whose gold Jacob had taken to fund the building project. Using four-leaf clover laced holy water Jacob manages to banish the Leprechaun, summoning demonic hands which drag him underground, but soon after drops dead of injuries inflicted by the Leprechaun during the fight.One year later two down on their luck friends Emily Woodrow (Tangi Miller) and Lisa Duncan (Sherrie Jackson) have their fortune told when the clairvoyant Esmeralda (Donzaleigh Abernathy) who warns them that they will attain great wealth soon, but it must be denied as it will come at a great price and summon a terrible evil. While having a barbecue at the abandoned youth center construction site with Lisa, their stoner friend Jamie Davis (Page Kennedy) and her ex-boyfriend turned drug dealer Rory Jackson (Laz Alonso) Emily falls through a hole and discovers the Leprechaun's gold in an old tunnel where it was hidden by Father Jacob. Splitting up the gold (which is produced in a never ending amount by the chest it was contained in) evenly the quartet of friends use it to fulfill their fantasies, unaware that by taking the gold they have released the Leprechaun, who begins stalking the group (killing a guest who takes one of his coins at a party held by Jamie, prompting the police to temporarily arrest him). At the salon where Emily works the Leprechaun sneaks in and, after killing a regular customer, Doria, on the massage table by breaking her neck, attacks Emily, who barely escapes and warns Rory and the recently released Jamie, who rush to get to Lisa's. In her house Lisa is attacked by the Leprechaun and manages to fight him off for a short while, but is killed when the Leprechaun claws her in the stomach, with her friends finding her body moments later.While Emily and Jamie want to return the gold Rory does not and takes off with it; shortly after realizing Rory is gone Emily is attacked and chased outside by the Leprechaun, but is saved when Rory has a change of heart and comes back for her. Searching for Rory the Leprechaun stops by his house and kills Rory's profligate girlfriend Chanel (Keesha Sharp) by tearing out her upper jaw, reclaiming the gold she used to make a tooth while Rory and Emily are stopped and harassed by Officers Thompson (Beau Billingslea) and Whitaker (Chris Murray). After the Leprechaun appears and kills the two officers Emily and Rory escape and regroup with Jamie, only to be confronted by a machine gun wielding group of Rory's drug dealing rivals, led by Watson (Shiek Mahmud-Bey) and Cedric (Sticky Fingaz). Planning on executing Rory for infringing on their territory Watson and his gang are all disposed of by the Leprechaun, (who kills Watson and Cedric while the other two members run off) while Emily, Rory and Jamie drive off in Watson's car (which the Leprechaun latches to the bottom of for a short while) and go looking for help from Esmeralda.Advised to use four-leaf clovers against the Leprechaun by Esmeralda, Rory laces the hollow-point bullets of his gun with clovers Jamie finds in the marijuana Rory had earlier sold him. When the Leprechaun arrives Rory shoots him several times with the clover bullets, only for his gun to jam before he can finish the Leprechaun off. Rory and Emily are given the chance to run with the gold when the Leprechaun is distracted by Jamie and Esmeralda (the latter dying in a magical duel with the Leprechaun). Followed to the roof of the building Rory tries fighting the Leprechaun and is knocked out, though before the Leprechaun can kill him
Question: Who was it that did not want to return the gold to the Leprechaun? | [
"rory"
] | task469-59f9165d813048dda142d232d38d2602 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Brian Rowsom (born October 23, 1965) is a retired American professional basketball player who was selected by the Indiana Pacers in the 2nd round (34th overall) of the 1987 NBA Draft.
Question: What team did Brian Rowsom play for? | [
"indiana pacers"
] | task469-9cb4b0b53a92451f8ffc059c16aced55 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Winchester Model 68 was a single-shot, bolt-action .22 caliber rimfire rifle sold from 1934 to 1945 by Winchester Repeating Arms Company.
Question: The Winchester Model 68 was produced by whom? | [
"winchester repeating arms company"
] | task469-27ff8f2f749b490e9689d501534efcd8 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: MS Viking Cinderella is a cruiseferry built in 1989 at Wartsila Marine Perno Shipyard in Turku, Finland, as MS Cinderella for SF Line, one of the owners of the Viking Line consortium.
Question: Which corporation created MS Viking Cinderella? | [
"wärtsilä marine"
] | task469-c5d43e87a62948269b0d7f365dc09311 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Lydia Potechina (5 September 1883 -- 7 April 1934) was a Russian actress.
Question: What was the date of birth of Lydia Potechina? | [
"5 september 1883"
] | task469-8b3c63737caa4ffb97279bf81b89b62d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Lysine 1423 of neurofibromin (neurofibromatosis type I gene product [NF1]) plays a crucial role in the function of NF1. Mutations of this lysine were detected in samples from a neurofibromatosis patient as well as from cancer patients. To further understand the significance of this residue, we have mutated it to all possible amino acids. Functional assays using yeast ira complementation have revealed that lysine is the only amino acid that produced functional NF1. Quantitative analyses of different mutant proteins have suggested that their GTPase-activating protein (GAP) activity is drastically reduced as a result of a decrease in their Ras affinity. Such a requirement for a specific residue is not observed in the case of other conserved residues within the GAP-related domain. We also report that another residue, phenylalanine 1434, plays an important role in NF1 function. This was first indicated by the finding that defective NF1s due to an alteration of lysine 1423 to other amino acids can be rescued by a second site intragenic mutation at residue 1434. The mutation partially restored GAP activity in the lysine mutant. When the mutation phenylalanine 1434 to serine was introduced into a wild-type NF1 protein, the resulting protein acquired the ability to suppress activated phenotypes of RAS2Val-19 cells. This suppression, however, does not involve Ras interaction, since the phenylalanine mutant does not stimulate the intrinsic GTPase activity of RAS2Val-19 protein and does not have an increased affinity for Ras proteins.
Question: Which is the gene mutated in type 1 neurofibromatosis? | [
"nf1"
] | task469-696b41a3ea5a4c3d9c96e4119493c1eb | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: During mitosis, Promyelocytic leukemia nuclear bodies (PML NBs) change dramatically in morphology and composition, but little is known about function of PML in mitosis. Here, we show that PML is phosphorylated at T409 (PML p409) in a mitosis-specific manner. More importantly, PML p409 contributes to maintain the duration of pro-metaphase and regulates spindle checkpoint. Deficient PML p409 caused a shortening of pro-metaphase and challenged the nocodazole-triggered mitotic arrest. T409A mutation led to a higher frequency of misaligned chromosomes on metaphase plate, and subsequently death in late mitosis. In addition, inhibition of PML p409 repressed growth of tumor cells, suggesting that PML p409 is a potential target for cancer therapy. Collectively, our study demonstrated an important phosphorylated site of PML, which contributed to explore the role of PML in mitosis.
Question: What is the effect of nocodazole cell treatment? | [
"mitotic arrest"
] | task469-75fb2a51eb90466782136b08a4be1ac4 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: From a human point of view, natural resources can be classified as either renewable or nonrenewable. Renewable resources are natural resources that are remade by natural processes as quickly as people use them. Examples of renewable resources include sunlight and wind. They are in no danger of being used up. Metals and some other minerals are considered renewable as well because they are not destroyed when they are used. Instead, they can be recycled and used over and over again. Living things are also renewable resources. They can reproduce to replace themselves. However, living things can be over-used or misused to the point of extinction. For example, over-fishing has caused some of the best fishing spots in the ocean to be nearly depleted, threatening entire fish species with extinction. To be truly renewable, living things must be used wisely. They must be used in a way that meets the needs of the present generation but also preserves them for future generations. Using resources in this way is called sustainable use. Nonrenewable resources are natural resources that cant be remade or else take too long to remake to keep up with human use. Examples of nonrenewable resources are coal, oil, and natural gas, all of which are fossil fuels. Fossil fuels form from the remains of plants and animals over hundreds of millions of years. We are using them up far faster than they can be replaced. At current rates of use, oil and natural gas will be used up in just a few decades, and coal will be used up in a couple of centuries. Uranium is another nonrenewable resource. It is used to produce nuclear power. Uranium is a naturally occurring chemical element that cant be remade. It will run out sooner or later if nuclear energy continues to be used. Soil is a very important natural resource. Plants need soil to grow, and plants are the basis of terrestrial ecosystems. Theoretically, soil can be remade. However, it takes millions of years for soil to form, so from a human point of view, it is a nonrenewable resource. Soil can be misused and eroded (see Figure 25.9). It must be used wisely to preserve it for the future. This means taking steps to avoid soil erosion and contamination of soil by toxins such as oil spills. Some of the resources we depend on the most are energy resources. Whether its powering our lights and computers, heating our homes, or providing energy for cars and other vehicles, its hard to imagine what our lives would be like without a constant supply of energy. Fossil fuels and nuclear energy are nonrenewable energy resources. People worldwide depend far more on these energy sources than any others. Figure 25.10 shows the worldwide consumption of energy sources by type in 2010. Nonrenewable energy sources accounted for 83 percent of the total energy used. Fossil fuels and the uranium needed for nuclear power will soon be used up if we continue to consume them at these rates. Using fossil fuels and nuclear energy creates other problems as well. The burning of fossil fuels releases carbon dioxide into the atmosphere. This is one of the major greenhouse gases causing global climate change. Nuclear power creates another set of problems, including the disposal of radioactive waste. Switching to renewable energy sources solves many of the problems associated with nonrenewable energy. While it may be expensive to develop renewable energy sources, they are clearly the way of the future. Figure 25.11 represents three different renewable energy sources: solar, wind, and biomass energy. The three types are described below. You can watch Bill Nyes introduction to renewable energy resources in this video: MEDIA Click image to the left or use the URL below. URL: Solar energy is energy provided by sunlight. Solar cells can turn sunlight into electricity. The energy in sunlight is virtually limitless and free and creates no pollution to use. Wind energy is energy provided by the blowing wind. Wind turbines, like those in Figure 25.11, can turn wind energy into electricity. The wind blows because of differences in heating of Earths atmosphere by the sun. There will never be a shortage of wind. Biomass energy is energy provided by burning
Question: If natural gas continues to be used at current rates, it will be used up in a few | [
"decades."
] | task469-8837ce79d4584279abe27b36f60ae746 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: A rocket is propelled into space by particles flying out of one end at high speed (see Figure 1.1). A rocket in space moves like a skater holding the fire extinguisher. Fuel is ignited in a chamber, which causes an explosion of gases. The explosion creates pressure that forces the gases out of the rocket. As these gases rush out the end, the rocket moves in the opposite direction, as predicted by Newtons Third Law of Motion. The reaction force of the gases on the rocket pushes the rocket forward. The force pushing the rocket is called thrust. Nothing would get into space without being thrust upward by a rocket. One of the first uses of rockets in space was to launch satellites. A satellite is an object that orbits a larger object. An orbit is a circular or elliptical path around an object. The Moon was Earths first satellite, but now many human- made "artificial satellites" orbit the planet. Thousands of artificial satellites have been put into orbit around Earth (Figure 1.2). We have even put satellites into orbit around the Moon, the Sun, Venus, Mars, Jupiter, and Saturn. There are four main types of satellites. Imaging satellites take pictures of Earths surface for military or scientific purposes. Imaging satellites study the Moon and other planets. Communications satellites receive and send signals for telephone, television, or other types of communica- tions. Navigational satellites are used for navigation systems, such as the Global Positioning System (GPS). The International Space Station, the largest artificial satellite, is designed for humans to live in space while conducting scientific research. Humans have a presence in space at the International Space Station (ISS) (pictured in Figure 1.3). Modern space stations are constructed piece by piece to create a modular system. The primary purpose of the ISS is scientific research, especially in medicine, biology, and physics. Craft designed for human spaceflight, like the Apollo missions, were very successful, but were also very expensive, could not carry much cargo, and could be used only once. To outfit the ISS, NASA needed a space vehicle that was reusable and able to carry large pieces of equipment, such as satellites, space telescopes, or sections of a space station. The resulting spacecraft was a space shuttle, shown in (Figure 1.4). Satellites operate with solar panels for energy. A photograph of the International Space Station was taken from the space shuttle Atlantis in June 2007. Construction of the station was completed in 2011, but new pieces and experiments continue to be added. A space shuttle has three main parts. The part you are probably most familiar with is the orbiter, with wings like an airplane. When a space shuttle launches, the orbiter is attached to a huge fuel tank that contains liquid fuel. On the sides of the fuel tank are two large "booster rockets." All of this is needed to get the orbiter out of Earths atmosphere. Once in space, the orbiter can be used to release equipment (such as a satellite or supplies for the International Space Station), to repair existing equipment such as the Hubble Space Telescope, or to do experiments directly on board the orbiter. When the mission is complete, the orbiter re-enters Earths atmosphere and flies back to Earth more like a glider than an airplane. The Space Shuttle program did 135 missions between 1981 and 2011, when the remaining shuttles were retired. The ISS is now serviced by Russian Soyuz spacecraft. Atlantis on the launch pad in 2006. Since 1981, the space shuttle has been the United States primary vehicle for carrying people and large equipment into space.
Question: the main purpose of the international space station is | [
"scientific research."
] | task469-1e925405754e41f487c360058274ad8f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Kanslikajen (Swedish: ''Chancellery Quay'') is a quay in Gamla stan, the old town of Stockholm, Sweden, leading west along the southern shore of the canal Stallkanalen from Stallbron and Mynttorget to Vasabron.
Question: Which is the body of water by Kanslikajen? | [
"stallkanalen"
] | task469-8b60c0eb0a62469eb80378d252cbc194 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Darwins theory of evolution by natural selection contains two major ideas: One idea is that evolution happens. Evolution is a change in the inherited traits of organisms over time. Living things have changed as descendants diverged from common ancestors in the past. The other idea is that evolution occurs by natural selection. Natural selection is the process in which living things with beneficial traits produce more offspring. As a result, their traits increase in the population over time. How did Darwin come up with the theory of evolution by natural selection? A major influence was an amazing scientific expedition he took on a ship called the Beagle. Darwin was only 22 years old when the ship set sail. The trip lasted for almost five years and circled the globe. Figure 7.2 shows the route the ship took. It set off from Plymouth, England in 1831. It wouldnt return to Plymouth until 1836. Imagine setting out for such an incredible adventure at age 22, and youll understand why the trip had such a big influence on Darwin. Darwins job on the voyage was to observe and collect specimens whenever the ship went ashore. This included plants, animals, rocks, and fossils. Darwin loved nature, so the job was ideal for him. During the long voyage, he made many observations that helped him form his theory of evolution. Some of his most important observations were made on the Galpagos Islands. The 16 Galpagos Islands lie 966 kilometers (about 600 miles) off the west coast of South America. (You can see their location on the map in Figure 7.2.) Some of the animals Darwin observed on the islands were giant tortoises and birds called finches. Watch this video for an excellent introduction to Darwin, his voyage, and the Galpagos: The Galpagos Islands are still famous for their giant tortoises. These gentle giants are found almost nowhere else in the world. Darwin was amazed by their huge size. He was also struck by the variety of shapes of their shells. You can see two examples in Figure 7.3. Each island had tortoises with a different shell shape. The local people even could tell which island a tortoise came from based on the shape of its shell. Darwin wondered how each island came to have its own type of tortoise. He found out that tortoises with dome- shaped shells lived on islands where the plants they ate were abundant and easy to reach. Tortoises with saddle- shaped shells, in contrast, lived on islands that were drier. On those islands, food was often scarce. The saddle shape of their shells allowed tortoises on those islands to reach up and graze on vegetation high above them. This made sense, but how had it happened? Darwin also observed that each of the Galpagos Islands had its own species of finches. The finches on different islands had beaks that differed in size and shape. You can see four examples in Figure 7.4. Darwin investigated further. He found that the different beaks seemed to suit the birds for the food available on their island. For example, finch number 1 in Figure 7.4 used its large, strong beak to crack open and eat big, tough seeds. Finch number 4 had a long, pointed beak that was ideal for eating insects. This seemed reasonable, but how had it come about? Besides his observations on the Beagle, other influences helped Darwin develop his theory of evolution by natural selection. These included his knowledge of plant and animal breeding and the ideas of other scientists. Darwin knew that people could breed plants and animals to have useful traits. By selecting which individuals were allowed to reproduce, they could change an organisms traits over several generations. Darwin called this type of change in organisms artificial selection. You can see an example in Figure 7.5. Keeping and breeding pigeons was a popular hobby in Darwins day. Both types of pigeons in the bottom row were bred from the common rock pigeon at the top of the figure. There were three other scientists in particular that influenced Darwin. Their names are Lamarck, Lyell, and Malthus. All three were somewhat older than Darwin, and he was familiar with their writings. Jean Baptiste Lamarck was a French naturalist
Question: ___scientist who proposed the theory of evolution by natural selection | [
"darwin"
] | task469-772b513415b64d3ca849b3ed0a906d76 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: A rock under enough stress will fracture. There may or may not be movement along the fracture. If there is no movement on either side of a fracture, the fracture is called a joint. The rocks below show horizontal and vertical jointing. These joints formed when the confining stress was removed from the rocks as shown in (Figure If the blocks of rock on one or both sides of a fracture move, the fracture is called a fault (Figure 1.2). Stresses along faults cause rocks to break and move suddenly. The energy released is an earthquake. How do you know theres a fault in this rock? Try to line up the same type of rock on either side of the lines that cut across them. One side moved relative to the other side, so you know the lines are a fault. Slip is the distance rocks move along a fault. Slip can be up or down the fault plane. Slip is relative, because there is usually no way to know whether both sides moved or only one. Faults lie at an angle to the horizontal surface of the Earth. That angle is called the faults dip. The dip defines which of two basic types a fault is. If the faults dip is inclined relative to the horizontal, the fault is a dip-slip fault (Figure 1.3). There are two types of dip-slip faults. In a normal fault, the hanging wall drops down relative to the footwall. In a reverse fault, the footwall drops down relative to the hanging wall. This diagram illustrates the two types of dip-slip faults: normal faults and reverse faults. Imagine miners extracting a re- source along a fault. The hanging wall is where miners would have hung their lanterns. The footwall is where they would have walked. A thrust fault is a type of reverse fault in which the fault plane angle is nearly horizontal. Rocks can slip many miles along thrust faults (Figure 1.4). At Chief Mountain in Montana, the upper rocks at the Lewis Overthrust are more than 1 billion years older than the lower rocks. How could this happen? Normal faults can be huge. They are responsible for uplifting mountain ranges in regions experiencing tensional stress. A strike-slip fault is a dip-slip fault in which the dip of the fault plane is vertical. Strike-slip faults result from shear stresses. Imagine placing one foot on either side of a strike-slip fault. One block moves toward you. If that block moves toward your right foot, the fault is a right-lateral strike-slip fault; if that block moves toward your left foot, the fault is a left-lateral strike-slip fault (Figure 1.5). Californias San Andreas Fault is the worlds most famous strike-slip fault. It is a right-lateral strike slip fault (See opening image). People sometimes say that California will fall into the ocean someday, which is not true. Strike-slip faults. Click image to the left or use the URL below. URL:
Question: this type of reverse fault has a plane angle that is nearly horizontal. | [
"thrust fault"
] | task469-00521082e03a48e49dc19257d1878905 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Villa Saraceno has been dated to the 1540s, which makes it one of Andrea Palladio's earlier works.
Question: Who created Villa Saraceno? | [
"andrea palladio"
] | task469-b00874270b884551862766f781f1c1b0 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Theatre of Tragedy was a Norwegian band from Stavanger, active between 1993 and 2010.
Question: What city is the band Theatre of Tragedy from? | [
"stavanger"
] | task469-8e8e8ccb8e0348e5afcdcde5cf361ff8 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The 1974 Norfolk mid-air collision happened on 9 August 1974 at Fordham Fen, Norfolk, England when a Royal Air Force McDonnell-Douglas Phantom FGR2 of 41 Squadron collided with a Piper Pawnee crop spraying aircraft.
Question: The point in time of 1974 Norfolk mid-air collision was when? | [
"9 august 1974"
] | task469-24c8b34ad80447f690bbe695e4d75da8 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Seahawks began their 2008 campaign on the road against the Buffalo Bills. In the first quarter, Seattle trailed early as Bills RB Marshawn Lynch got a 21-yard TD run. In the second quarter, the Seahawks continued to struggle as WR/PR Roscoe Parrish returned a punt 63 yards for a touchdown. Seattle responded with QB Matt Hasselbeck completing a 20-yard TD pass to WR Nate Burleson. Buffalo closed out the half with kicker Rian Lindell getting a 35-yard and a 38-yard field goal. In the third quarter, the Seahawks replied with kicker Olindo Mare nailing a 45-yard field goal. However, the Bills pulled a trick play on Seattle. Appearing to go for a 32-yard field goal, Buffalo's holder (punter Brian Moorman) instead threw a 19-yard TD pass to DE Ryan Denney. The Bills pulled away with QB Trent Edwards completing a 30-yard TD pass to TE Robert Royal.
Question: Did more field goals occur in the first or second half of the game? | [
"first"
] | task469-947b1e1952ab45a58c78a1320bd37af9 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Ayalon River (Hebrew: , Nahal Ayalon; Nahr el-Barideh or Wadi Musrara in Arabic) is a perennial stream in Israel, originating in the Judean Hills and discharging into the Yarkon River in the area of Tel Aviv.
Question: What river does Ayalon River form a part of? | [
"yarkon river"
] | task469-1b7063d409054d17bee5c8140160c24d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Sunda Kelapa (Sundanese: Sunda Kalapa) is the old port of Jakarta located on the estuarine of Ciliwung River.
Question: Which is the body of water by Sunda Kelapa? | [
"ciliwung river"
] | task469-de761bcb8d6040d49622d385ef710721 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Carbon is a very important element to living things. As the second most common element in the human body, we know that human life without carbon would not be possible. Protein, carbohydrates, and fats are all part of the body and all contain carbon. When your body breaks down food to produce energy, you break down protein, carbohydrates, and fat, and you breathe out carbon dioxide. Carbon occurs in many forms on Earth. The element moves through organisms and then returns to the environment. When all this happens in balance, the ecosystem remains in balance too. The short term cycling of carbon begins with carbon dioxide (CO2 ) in the atmosphere. Through photosynthesis, the inorganic carbon in carbon dioxide plus water and energy from sunlight is transformed into organic carbon (food) with oxygen given off as a waste product. The chemical equation for photosynthesis is: Plants and animals engage in the reverse of photosynthesis, which is respiration. In respiration, animals use oxygen to convert the organic carbon in sugar into food energy they can use. Plants also go through respiration and consume some of the sugars they produce. The chemical reaction for respiration is: C6 H12 O6 + 6 O2 6 CO2 + 6 H2 O + useable energy Photosynthesis and respiration are a gas exchange process. In photosynthesis, CO2 is converted to O2 ; in respiration, O2 is converted to CO2 . Remember that plants do not create energy. They change the energy from sunlight into chemical energy that plants and animals can use as food (Figure 1.1). Places in the ecosystem that store carbon are reservoirs. Places that supply and remove carbon are carbon sources and carbon sinks, respectively. If more carbon is provided than stored, the place is a carbon source. If more carbon dioxide is absorbed than is emitted, the reservoir is a carbon sink. What are some examples of carbon sources and sinks? Carbon sinks are reservoirs where carbon is stored. Healthy living forests and the oceans act as carbon sinks. Carbon sources are reservoirs from which carbon can enter the environment. The mantle is a source of carbon from volcanic gases. A reservoir can change from a sink to a source and vice versa. A forest is a sink, but when the forest burns it becomes a source. The amount of time that carbon stays, on average, in a reservoir is the residence time of carbon in that reservoir. Remember that the amount of CO2 in the atmosphere is very low. This means that a small increase or decrease in the atmospheric CO2 can have a large effect. By measuring the composition of air bubbles trapped in glacial ice, scientists can learn the amount of atmospheric CO2 at times in the past. Of particular interest is the time just before the Industrial Revolution, when society began to use fossil fuels. That value is thought to be the natural content of CO2 for this time period; that number was 280 parts per million (ppm). By 1958, when scientists began to directly measure CO2 content from the atmosphere at Mauna Loa volcano in the Pacific Ocean, the amount was 316 ppm (Figure 1.2). In 2014, the atmospheric CO2 content had risen to around 400 ppm. The amount of CO2 in the atmosphere has been measured at Mauna Loa Obser- vatory since 1958. The blue line shows yearly averaged CO2 . The red line shows seasonal variations in CO2 . This is an increase in atmospheric CO2 of 40% since the before the Industrial Revolution. About 65% of that increase has occurred since the first CO2 measurements were made on Mauna Loa Volcano, Hawaii, in 1958. Humans have changed the natural balance of the carbon cycle because we use coal, oil, and natural gas to supply our energy demands. Fossil fuels are a sink for CO2 when they form, but they are a source for CO2 when they are burned. The equation for combustion of propane, which is a simple hydrocarbon looks like this: The equation shows that when propane burns, it uses oxygen and produces carbon dioxide and water. So when a car burns a tank of gas, the amount of CO2 in the atmosphere increases just a little. Added over
Question: this is an example of a carbon source. | [
"volcano"
] | task469-16130f3ed71e44f8af529f18712a8782 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In the opening scene, private detective Sam Grunion (Groucho Marx) explains to the viewers that he has been searching for the extremely valuable Royal Romanoff diamonds for eleven years, and his investigation leads him to a troupe of struggling performers, led by Mike Johnson (Paul Valentine), who are trying to put on a musical revue called 'Love Happy'.Grunion notes that the impoverished young dancers would starve were it not for the sweet, silent Harpo (Harpo Marx), at Herbert & Herbert, a gourmet food shop that also trafficks in stolen diamonds. Harpo kindly helps ladies with their shopping bags, all the while pilfering their groceries and stuffing them in the pockets of his long trench coat. When the elegant Madame Egelichi (Ilona Massey) arrives, store manager Lefty Throckmorton (Melville Cooper) tells her that "the sardines" have come in. Harpo sneaks into the basement and watches as Lefty lovingly unpacks a sardine can marked with a Maltese cross, and swipes the can from Lefty's pocket, replacing it with an unmarked one. Madame Egelichi, who has gone through eight husbands in three months in her quest for the Romanoff diamonds, is furious when Lefty produces the wrong can. When Lefty remembers seeing Harpo in the basement, she orders him to call the police and offer a $1,000 reward for his capture.At the theater, meanwhile, unemployed entertainer Faustino the Great (Chico Marx) asks Mike for a job as a mind-reader, and when Faustino's clever improvisation stops the show's backer, Mr. Lyons (Leon Belasco), from repossessing the scenery, Mike gratefully hires him. Harpo, who is secretly in love with dancer Maggie Phillips (Vera-Ellen), Mike's girl friend, gives her the sardine can, and she says she will eat them tomorrow. A policeman sees Harpo inside the theater and brings him to Madame Egelichi, who turns Harpo over to her henchmen, Alphonse (Raymond Burr) and Hannibal (Bruce Gordon) Zoto. After three days of interrogation, Harpo still refuses to talk, and when he is left alone, he calls Faustino at the theater, using the bike horn he carries in his pocket to communicate. Madame Egelichi listens on the extension as Faustino declares that there are plenty of sardines at the theater, and she goes there at once.Meanwhile, Mike has just finished telling the troupe that they do not have enough money to open when Madame Egelichi arrives and offers to finance the show. Mike cancels his plans to take Maggie out for her birthday so that he and his new backer can discuss the arrangements. In the alley outside the theater, Harpo, having escaped from Madame Egelichi's suite, finds the diamonds in the sardine can which had been set out for a cat, and puts them in his pocket. When he finds Maggie crying in her dressing room, Harpo takes her to Central Park, where he plays the harp for her and gives her the diamonds as a birthday gift.On the opening night of the show, Grunion is visited by an agent of the Romanoff family, who threatens to kill him if he does not produce the diamonds in an hour. At the theater, Lefty and the Zoto brothers spy through a window as Maggie puts on the diamond necklace, but Mike asks her not to wear it, promising to buy her an engagement ring instead. As they kiss, Maggie removes the necklace and drops it on the piano strings. The curtain goes up, and when Harpo sees Lefty and the Zoto brothers menacing Maggie, he distracts them with a piece of costume jewelry and leads them up to the roof.Meanwhile, on stage, Faustino plays the piano, and when he strikes the keys forcefully, the diamond necklace flies into the air, drawing the attention of Madame Egelichi, who is watching from the audience. Faustino pockets the diamonds, then rushes to the roof to help Harpo. Madame Egelichi shows up with a gun and demands the necklace, but Faustino gives her the fake diamonds. After tying up Lefty and the Zotos and recovering the real diamonds, Harpo encounters Grunion, who has been hiding on the roof. Harpo drops the diamonds in Grunion
Question: Who does Mike cancel plans with? | [
"maggie"
] | task469-163ea0931b5e4adbb3510ecb1debe861 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Cotinguiba Esporte Clube play their home games at Estadio Lourival Baptista, nicknamed Batistao.
Question: Which is the stadium of Cotinguiba Esporte Clube? | [
"batistão"
] | task469-b6a3b5a5f6b248cf85647b08fca5b7fb | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Harley-Davidson, Inc. (H-D), or Harley, is an American motorcycle manufacturer, founded in Milwaukee, Wisconsin in 1903.
Question: The product of Harley-Davidson is what? | [
"motorcycle"
] | task469-a4f4013991994bc8b23014131bec3dd9 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Gora Rudnaya mine is one of the largest gold mines in Russia and in the world.
Question: What product does Gora Rudnaya mine make? | [
"gold"
] | task469-b4b86c0c3f89460082be252b88e4d789 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Raytown Branch of Mid-Continent Public Library is offering the following activities for the month of March. The library is located at 6131 Raytown Road. All activities are free, but registration is required. Tax Help for Seniors 10 a.m. Mondays and Wednesdays. AARP Tax-Aide representatives will be at the Library to assist seniors with medium to low incomes with tax questions and free tax return preparation. Time listed indicates starting time. Teen Games 2 p.m. March 2. Challenge yourself, challenge your friends. Movie Classics For adults, 2 p.m. March 4. Join us for an afternoon of nostalgia as we watch classic films. Call to see what's showing. KC Zoomobile Africa, for ages 5 and older, 11 a.m. March 5. Join the Kansas City Zoo for an African adventure. We will share African culture as well as show you an animal or two. Come with us to learn something new about Africa. Kids at the Library For ages 6 and older, 11 a.m. March 12. Discover, create, and play. Explore big ideas in a new way. Chess Free Play For ages 6 and older, 1 p.m. March 12. Play chess, learn the basics, brush up on your chess skills, challenge other players at Free Chess Play at the library. The Raytown Branch, in cooperation with the Raytown High School Chess Team coaches, will be hosting chess on the second Saturday of the month from 1 to 3 p.m. Chess boards and chess pieces will be provided. Eggstravaganza Noon March 26. Join us for story time with Mayor Mike McDonough, as we take part in Raytown's Easter festivities. After the stories, the Easter Bunny will escort the children across the street for an Easter egg hunt.
Question: Which activity is more likely to develop imagination and creativity? | [
"kids at the library."
] | task469-df0fa8397c254c79b988c9c2ba8c5d24 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: 3sat began broadcasting on 1 December 1984.
Question: What year did 3sat start? | [
"1 december 1984"
] | task469-72fe733b5c3943ab825920c43ba2ee75 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Elections to the European Parliament were held in France on 13 June 2004.
Question: What is the full date that Elections to the European Parliament crashed on? | [
"13 june 2004"
] | task469-ff4b0ca411614cc686d70658ed53aed5 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Ruling Voice is a 1931 American Pre Code gangster drama directed by Rowland V. Lee, starring Walter Huston, Loretta Young and Doris Kenyon.
Question: In which The Ruling Voice a 1909 american silent drama film directed by? | [
"rowland v. lee"
] | task469-1c2963d542a245cbb0c75c61d97f7395 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Trying to avoid a five-game losing streak, the Broncos went home for a Week 12 Interconference Duel against the New York Giants. In the first quarter the Broncos got on the board with kicker Matt Prater making a 26-yard field goal and then a 32-yard field goal in the second quarter. The Broncos kept on top with RB Knowshon Moreno making a 1-yard touchdown run. After that Matt Prater made a 47-yard field goal to end the half. In the third quarter the Giants replied with kicker Lawrence Tynes nailing a 39 then a 52-yard field goal. In the fourth quarter Denver increased their lead with QB Kyle Orton making a 17-yard touchdown pass to WR Brandon Stokley, and Prater making a 24-yard field goal.
Question: What was the last score type of the first half? | [
"field goal"
] | task469-9ca9d99ada704c9aacd60ce367a87e0f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Imatinib is one of the most recent medications used for the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST). It is an orally administered protein-tyrosine kinase inhibitor, an enzyme which is produced by BCR-ABL fusion which results from translocation of 9:22 chromosome (Philadelphia chromosome). Imatinib blocks proliferation and induces apoptosis of BCR-ABL-expression in CML. Many side effects produced by imatinib have been documented but its induction of hepatotoxcity has been rarely reported. Only a few cases so far have been reported in the literature and almost all were in females. We describe another case of hepatotoxicity due to imatinib in a 17-year old female with clinical, laboratory and histopathological changes. The case described here suggests that imatinib may also induce immune hepatitis, in some patients.
Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)? | [
"bcr-abl"
] | task469-142dc9320fa44fe7af88a96ef9a77969 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The National American Woman Suffrage Association (NAWSA) was formed on February 18, 1890 to work for women's suffrage in the United States.
Question: What is year of inception of National American Woman Suffrage Association? | [
"1890"
] | task469-267c56ba55ac469e88ce00fd6481c5a3 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Set in the Australian outback in the 1880s, the movie follows the series of events following the horrific rape and murder of the Hopkins family, allegedly committed by the infamous Burns brothers gang.The film opens in a brothel during a violent gunfight between the police and Charlie Burns' (Guy Pearce) gang, which ends with the deaths of all of the gang members except for Charlie and his younger brother Mikey. Captain Stanley (Ray Winstone) proposes to Charlie: he and Mikey can go free of the crimes they have committed if Charlie kills his older brother, Arthur (Danny Huston). Arthur is a mercurial psychopath who has become something of a legend and is so vicious that the Aboriginal tribes refer to him as "The Dog Man" and both the police and the Aboriginals refuse to go near his camp. Captain Stanley muses that perhaps the bounty hunters will kill Arthur in time and then states his intention to civilize the harsh Australian wilderness by bringing Arthur to justice and using Mikey as leverage. Charlie has nine days to find and kill Arthur, or else Mikey will be hanged from the gallows on Christmas Day.We discover why Captain Stanley is intent on taming Australia: he has been forced to move there with his delicate wife, Martha Stanley (Emily Watson), and apparently wants to make it an appropriate place for them to live. The Stanleys were also friends of the Hopkins family, leading Martha to have nightmares about her dead friends and the unborn child one of them is revealed to have carried. Word spreads of Stanley's deal with Charlie, primarily from Stanley's corrupt subordinate, Sergeant Lawrence (Robert Morgan), causing disgust among the townspeople.Shortly thereafter, Eden Fletcher (David Wenham), for whom Captain Stanley works, orders that Mikey be given one hundred lashes as punishment for the rape and murder of the Hopkins family. Stanley is aghast at this, not only because he believes that Mikey is innocent and the flogging will surely kill him, but because it would also break his deal with Charlie and thus put him and his wife in grave danger. Stanley sends Sergeant Lawrence away with tracker Jacko (David Gulpillil) and other men to "investigate" the reported slaying of Dan O'Riley by a group of Aborigines. Captain Stanley attempts to defend Mikey by gunpoint from the bloodthirsty townspeople, but is overruled once Martha arrives, insisting on revenge for her dead friends. Mikey is then brutally flogged, and horrifically wounded. The formerly excited townspeople slowly become disgusted and Martha faints at the ghastly display. After 40 lashes, Mikey has collapsed and the whip is soaked with blood. Captain Stanley grabs the whip and throws it at Fletcher, staining his face and suit with blood, who in turn fires Stanley.Meanwhile, Charlie rides a great distance in search of Arthur, drinking and apparently reflecting on what he will do. Along the way, he encounters an inebriated old man named Jellon Lamb (John Hurt). In the course of conversation, Charlie realizes that Lamb is a bounty hunter in pursuit of the Burns brothers and knocks him out. Later on, after sleeping on a rock bed, Charlie awakes and, before he can gather what's going on, is speared in the chest by a group of Aboriginal men standing over him. Seconds later a gunshot is heard and the head of the man who threw the spear explodes. Charlie then passes out.Charlie wakes up in the camp of his brother Arthur, which is located in caves among desolate mountains. Arthur's gang consists of Samuel Stoat (Tom Budge), who shot the Aboriginal man who had speared Charlie; a woman named Queenie (Leah Purcell) who tends to Charlie's wound; and a muscular Aboriginal man called Two-Bob (Tom E. Lewis). As he recovers from his wounds, Charlie has several opportunities to kill his brother, but does not. Not too far away from Arthur's camp, Sergeant Lawrence and his men have found and butchered a group of Aborigines. Arthur and Two-Bob find Lawrence's group while they sleep, ostensibly to get a horse for Charlie, and proceed to kill Jacko and Sergeant Lawrence. Before Arthur stomps Lawrence
Question: What is Arthur referred to as by the Aborigines? | [
"the dog man"
] | task469-f81046538fe34daeb16ab1a4eddcb769 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Proteins of the Notch family are cell surface receptors that transduce signals between neighbouring cells. The Notch signalling pathway is highly evolutionarily conserved and critical for cell fate determination during embryonic development, including many aspects of vascular development. The interaction of Notch receptors with ligands leads to cleavage of the Notch intracellular domain (NICD) which then translocates to the nucleus and activates the transcription factor CBF1/JBP-Jkappa, regulating downstream gene expression. To date four Notch receptors have been found in mammals. Of these, Notch3 is predominantly expressed in adult arterial smooth muscle cells in human. NOTCH3 gene mutations cause the autosomal dominant condition, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoecephelopathy (CADASIL), an inherited early stroke syndrome leading to dementia due to systemic vascular degeneration. This suggests that Notch3 plays a critical role in maintaining the phenotypic stability of vascular smooth muscle cells (VSMCs). Recent publications indicate that Notch3 is involved in vascular injury and is a determinant of VSMC survival, but its exact function is unknown. The molecular mechanisms underlying CADASIL pathology are therefore intriguing. Investigation of CADASIL mutant Notch3 shows that the majority of mutations do not change CBF1/JBP-Jkappa mediated classic Notch activation, so the pathological consequences of NOTCH3 mutations in CADASIL patients can not be simply explained by loss- or gain-of-function in the classic Notch signalling pathway. This suggests that a novel Notch3-mediated signalling pathway may be present in VSMCs, or cross-regulation of Notch3 to other signalling pathway(s) may play a critical role on VSMCs survival. Alternatively, the mutant Notch3 may gain a novel or toxic function in VSMCs. This review will focus on recent findings of Notch3 in vascular development and in regulating the VSMC behaviour and phenotype, and will use findings on investigating the molecular pathology of the single gene disorder CADASIL to understand the function of Notch3 in VSMCs.
Question: Which gene is involved in CADASIL? | [
"notch3 gene"
] | task469-101a78cb3e6c4dcd8033cef9a8aa248f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Human apolipoprotein E (apoE) is a 299-amino-acid protein with a molecular weight of 34 kDa. The difference between the apoE3 and apoE4 isoforms is a single residue substitution involving a Cys-Arg replacement at residue 112. ApoE4 is positively associated with atherosclerosis and late-onset and sporadic Alzheimer's disease (AD). ApoE4 and its C-terminal truncated fragments have been found in the senile plaques and neurofibrillary tangles in the brain of AD patients. However, detail structural information regarding isoform and domain interaction remains poorly understood. We prepared full-length, N-, and C-terminal truncated apoE3 and apoE4 proteins and studied their structural variation. Sedimentation velocity and continuous size distribution analysis using analytical ultracentrifugation revealed apoE3(72-299) as consisting of a major species with a sedimentation coefficient of 5.9. ApoE4(72-299) showed a wider and more complicated species distribution. Both apoE3 and E4 N-terminal domain (1-191) existed with monomers as the major component together with some tetramer. The oligomerization and aggregation of apoE protein increased when the C-terminal domain (192-271) was incorporated. The structural influence of the C-terminal domain on apoE is to assist self-association with no significant isoform preference. Circular dichroism and fluorescence studies demonstrated that apoE4(72-299) possessed a more alpha-helical structure with more hydrophobic residue exposure. The structural variation of the N-terminal truncated apoE3 and apoE4 protein provides useful information that helps to explain the greater aggregation of the apoE4 isoform and thus has implication for the involvement of apoE4 in AD.
Question: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease? | [
"apoe4 isoform",
"apolipoprotein e4 isoform"
] | task469-27388352f325400aa730361ede2305b4 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Joaquim Silva (born January 13, 1961) is a retired long-distance runner from Portugal, who won the 1994 edition of the Vienna Marathon.
Question: What is Joaquim Silva's country of citizenship? | [
"portugal"
] | task469-ec855281085949e995615db45cfa9274 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The James Bay mine is one of the largest lithium mines in Canada.
Question: What product does James Bay mine make? | [
"lithium"
] | task469-644e7edb171f465e8688de90da51e183 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Caste War of Yucatan was a conflict that lasted from 1847 to 1901. It began with the revolt of native Maya people led by Maya chiefs Jacinto Pat and Cecilio Chi, against the population of European descent called "Yucatecos", who had political and economic control. A lengthy war ensued between the Yucateco forces in the north-west of the Yucatan and the independent Maya in the south-east. It officially ended with the occupation of the Maya capital of Chan Santa Cruz by the Mexican army in 1901, although skirmishes with villages and small settlements that refused to acknowledge Mexican control continued for over another decade. Adam Jones wrote: "This ferocious race war featured genocidal atrocities on both sides, with up to 200,000 killed." Because of the conflict, on November 24, 1902, Yucatan had a second territorial division when Porfirio Diaz decreed the creation of the Federal Territory of Quintana Roo, with capital in the port of Payo Obispo . In little more than half a century, Yucatan lost more than two thirds of its original territory.
Question: Who had control of the area after 1901? | [
"mexican army"
] | task469-e07c9b521bd44b05a4ba67733bb47ff2 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Patriots clinched their fourth straight AFC East title with a close road win. After a scoreless first quarter, the Jaguars responded to a Gostkowski field goal with a Maurice Jones-Drew touchdown run. The Patriots challenged the play, as Jones-Drew appeared to fall down at the line of scrimmage, but the ruling on the field was upheld. New England came back before the halftime to retake the lead at 10-7 on a Dillon one-yard touchdown run. The Patriots maintained their lead as the teams traded touchdowns in the second half, including another touchdown by Jones-Drew. A David Garrard fumble with 1:55 left in the fourth quarter, recovered by safety Rodney Harrison, sealed the Patriots' 11th win of the season.
Question: Which team scored first in the game? | [
"patriots"
] | task469-b3f1e5a513704cc09718c0b57627e265 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Plunkett finished the game with 16 out of 25 pass completions for 172 yards and a touchdown. Theismann threw for more yards than Plunkett (243), but was just 16 out of 35 and was intercepted twice. He was also sacked six times. Branch was the top receiver of the game with six receptions for 94 yards and a touchdown. Guy punted seven times for 299 yards (42.7 average), with 244 net yards (34.8 average) and planted five of his seven punts inside the 20. Martin recorded a sack, a pass deflection, and a fumble recovery. Riggins, who had rushed for over 100 yards in his last six postseason games, was held to 64 yards and a touchdown on 26 carries, with his longest gain being just 8 yards. Brown was their top receiver with three receptions for 93 yards. Tight end Clint Didier caught five passes for 65 yards. Garrett recorded 100 yards on kickoff returns, and one reception for 17 yards. Part of both of Allens touchdown runs were cutbacks, which, according to New York Daily News writer Larry Fox, burned an overpursuing Redskins defense.
Question: Who had more yards per reception on average, Clint Didier or Brown? | [
"brown"
] | task469-0a5c8d137fc141268fb89f84c38cc7e2 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Minors with a stated age <18 years unaccompanied by a responsible adult form an increasing part of refugees to Europe. They are older than other asylum-seeking children and many come from countries with a high tuberculosis (TB) incidence. During the 2015 refugee crisis, 35,369 of 162,877 refugees (22%) seeking asylum in Sweden were unaccompanied minors, which gave us the opportunity to study their burden of TB infection and disease. Of the unaccompanied minors seeking asylum in Sweden during 2015, 2936 (8.3%) were allocated to northern Stockholm. Of these, 2422 were from countries with an incidence of TB exceeding 100/10 Of those screened, 349 had a positive test and were referred to the northern paediatric TB clinic at Astrid Lindgren Children's Hospital. Of these, 16 had TB disease and 278 latent tuberculosis infection (LTBI), while we considered 53 uninfected. In addition, eight sought medical attention with symptomatic TB outside the screening system. Cohort rates were 6.8% of LTBI and 0.5% of TB in minors from Afghanistan and 26-32% of LTBI and 3.4-3.5% of TB among those from Eritrea, Ethiopia or Somalia. We conclude that TB infection and disease is common among asylum-seeking unaccompanied minors, especially among those from the Horn of Africa.
Question: The Mantoux test detects what latent infection/disease? | [
"tuberculosis"
] | task469-a8ba1b48246d4aefa43ba6422a023698 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The nervous system controls sensing, feeling, and thinking. It also controls movement and just about every other body function. Thats why problems with the nervous system can affect the entire body. Diseases of the nervous system include brain and spinal cord infections. Other problems of the nervous system range from very serious diseases, such as tumors, to less serious problems, such as tension headaches. Some of these diseases are present at birth. Others begin during childhood or adulthood. When you think of infections, you probably think of an ear infection or strep throat. You probably dont think of a brain or spinal cord infection. But bacteria and viruses can infect these organs as well as other parts of the body. Infections of the brain and spinal cord are not very common. But when they happen, they can be very serious. Thats why its important to know their symptoms. Encephalitis is a brain infection ( Figure 1.1). If you have encephalitis, you are likely to have a fever and headache or feel drowsy and confused. The disease is most often caused by viruses. The immune system tries to fight off a brain infection, just as it tries to fight off other infections. But sometimes this can do more harm than good. The immune systems response may cause swelling in the brain. With no room to expand, the brain pushes against the skull. This may injure the brain and even cause death. Medicines can help fight some viral infections of the brain, but not all infections. Meningitis is an infection of the membranes that cover the brain and spinal cord. If you have meningitis, you are likely to have a fever and a headache. Another telltale symptom is a stiff neck. Meningitis can be caused by viruses or bacteria. Viral meningitis often clears up on its own after a few days. Bacterial meningitis is much more serious ( Figure 1.2). It may cause brain damage and death. People with bacterial meningitis need emergency medical treatment. They are usually given antibiotics to kill the bacteria. A vaccine to prevent meningitis recently became available. It can be given to children as young as two years old. Many doctors recommend that children receive the vaccine no later than age 12 or 13, or before they begin high school. A condition called Reyes syndrome can occur in young people that take aspirin when they have a viral infection. The syndrome causes swelling of the brain and may be fatal. Fortunately, Reyes syndrome is very rare. The best way to prevent it is by not taking aspirin when you have a viral infection. Products like cold medicines often contain aspirin. So, read labels carefully when taking any medicines ( Figure 1.3). Since 1988, the U.S. Food and Drug Ad- ministration has required that all aspirin and aspirin-containing products carry a warning about Reyes syndrome. Like other parts of the body, the nervous system may develop tumors. A tumor is a mass of cells that grows out of control. A tumor in the brain may press on normal brain tissues. This can cause headaches, difficulty speaking, or other problems, depending on where the tumor is located. Pressure from a tumor can even cause permanent brain damage. In many cases, brain tumors can be removed with surgery. In other cases, tumors cant be removed without damaging the brain even more. In those cases, other types of treatments may be needed. Cerebral palsy is a disease caused by injury to the developing brain. The injury occurs before, during, or shortly after birth. Cerebral palsy is more common in babies that have a low weight at birth. But the cause of the brain injury is not often known. The disease usually affects the parts of the brain that control body movements. Symptoms range from weak muscles in mild cases to trouble walking and talking in more severe cases. There is no known cure for cerebral palsy. Epilepsy is a disease that causes seizures. A seizure is a period of lost consciousness that may include violent muscle contractions. It is caused by abnormal electrical activity in the brain. The cause of epilepsy may be an infection, a brain injury, or a tumor
Question: which nervous system disease causes seizures? | [
"epilepsy"
] | task469-dcb08da9ce1d4e3d85cdfa14974f32ba | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Centrioles are essential for the formation of cilia and flagella. They also form the core of the centrosome, which organizes microtubule arrays important for cell shape, polarity, motility and division. Here, we have used super-resolution 3D-structured illumination microscopy to analyse the spatial relationship of 18 centriole and pericentriolar matrix (PCM) components of human centrosomes at different cell cycle stages. During mitosis, PCM proteins formed extended networks with interspersed -Tubulin. During interphase, most proteins were arranged at specific distances from the walls of centrioles, resulting in ring staining, often with discernible density masses. Through use of site-specific antibodies, we found the C-terminus of Cep152 to be closer to centrioles than the N-terminus, illustrating the power of 3D-SIM to study protein disposition. Appendage proteins showed rings with multiple density masses, and the number of these masses was strongly reduced during mitosis. At the proximal end of centrioles, Sas-6 formed a dot at the site of daughter centriole assembly, consistent with its role in cartwheel formation. Plk4 and STIL co-localized with Sas-6, but Cep135 was associated mostly with mother centrioles. Remarkably, Plk4 formed a dot on the surface of the mother centriole before Sas-6 staining became detectable, indicating that Plk4 constitutes an early marker for the site of nascent centriole formation. Our study provides novel insights into the architecture of human centrosomes and illustrates the power of super-resolution microscopy in revealing the relative localization of centriole and PCM proteins in unprecedented detail.
Question: Where in the cell do we find the protein Cep135? | [
"centrosome"
] | task469-79478651b84a4ae59ceb9d4fd6bb01bd | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Duke's Cut was completed by the Duke of Marlborough in 1789 to link the new canal with the River Thames; and, in 1796, the Oxford Canal company built its own link to the Thames, at Isis Lock.
Question: By which body of water is Oxford located? | [
"river thames"
] | task469-62d25fdf62104fb1a6cfc6326e47c39c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The scene opens with Ellen (Sharon Stone) riding across the prairie toward a town, when an idiot digging multiple holes looking for his gold, shoots at her. She falls off her horse and knocks him out as he checks to see if she is dead. After chaining him to his wagon, she continues into town. A large, single elimination gun fighting tournament is about to begin and she is looking for revenge on the man ( Herod/Gene Hackman) who killed her father. She arrives at the bar/hotel. Ace Hanlon shows off his deck of cards with an ace for every man he has killed. Soon, the saloon comes to life as Scars who just got out of jail, comes back to settle a score. He makes a move on Ellen, and she tells him to take a bath. Scars gets angry and kicks the blind boy's peddling wagon, as he was talking to Ellen. Later at the drafting of the tournament, the saloon owner is to sign up 16 gunfighters. Among them are The Kid (Leonardo DiCaprio), Sgt. Cantrell (Kieth David), Cort, the marksman and odds on favorite (Russell Crowe) though he was signed up against his will. Cort was an outlaw who became a preacher and built a mission. Since he was one of Herod's partners in crime, Herod now wants Cort dead. Also in the contest is Ace Hanlon ( Lance Herrickson), A Swedish Champ. and of course Herod. Anyone can challenge anyone, and each fighter must accept the first challenge. Ellen is challenged by the idiot who was digging for his lost gold. But up first was the Kid and he quickly shot the Swede and the winner is the last standing.The Swede was shot twice and then threw his gun down. Also winning, were Stg. Cantrell, Scars, and Eugene the scumbag. Herod has challenged Ace(because he thinks Ace was hired to kill him) and one of Herod's men challenged Cort. After Rusty, another of Herod's men has beaten Cort up as he was chained to a fountain in the middle of the village. Herod has Cort released so that he can go to the Kid's gun store. Herod gives Cort the cheapest gun in the place. The Kid also has told everyone that Herod was his father. Herod denies that and rubs it in the Kid's face. Then Cort went out to a fight that he refused to be in. But when the clock stuck, only one bullet was fired. Herod's man fell to the ground. Many claimed to be the fastest gun in town, like the Kid, Herod, and Ace, but all knew that Cort was the fastest. Next, Ace is bragging and doing gun tricks. It is time for he and Herod to face each other. Herod proves that Ace has been lying about all of his kills. The clock strikes and Herod blows Ace's right thumb off. Then he shoots Ace's left hand. Then after mocking Ace some more, Herod's shoots him in the chest. Then Ellen wins her first fight with Cort's help. The next day, Herod invites Stg. Cantrel to his home. He tells the Sgt, that he knows that he was the hired hand and not Ace. The Sgt. does not tell him much and the challenge has been issued. Later, Herod changes the rules and now all fights are to the death. Herod takes down Cantrell, and then scolds the crowd for hiring him. Meantime, Eugene the scum bag is heard upstairs molesting a girl. He comes downstairs and brags about it. Ellen attacks him from behind and the two scream at each other until the challenge is made. though it is pouring outside, The two come out firing and Eugene gets his manhood shot off. The rules have changed and the winner is the last alive. Ellen couldn't finish him off, so she returned to the bar. Eugene comes in and shoots her glass. Then Ellen empties her gun into him.Though Herod tells the Kid to quit, that he has proven his point, the Kid stays in and takes
Question: The lady's father was strung up by whose men? | [
"herod"
] | task469-8a75e6e8621e4e57bd3509d37423aa67 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Romano-Ward long-QT Syndrome (LQTS) is an autosomal dominant inherited trait characterized by prolonged QT interval on ECG, life-threatening arrhythmias, syncope, and sudden death in affected individuals. A gene responsible for this disorder has been shown to be linked to the Harvey ras-1 locus (H-ras-1) DNA marker on the short arm of chromosome 11 (11p) in 7 families. The purpose of this study was to determine, by analyzing 23 families with LQTS for linkage to chromosome 11p, whether evidence exists for more than one gene causing LQTS (ie, locus heterogeneity). Twenty-three families (262 family members) were clinically evaluated using medical histories, ECGs, and Holter recordings. Each corrected QT interval (QTc) were determined using Bazett's formula. Blood for DNA extraction and cell line immortalization was obtained after informed consent. Southern blotting and polymerase chain reaction were performed, and linkage analysis carried out using the LINKAGE computer program (v 5.03). Genetic heterogeneity was determined using the HOMOG 2 (v 2.51) computer program. Twenty-three families were studied for evidence of linkage to chromosome 11p using the H-ras-1 locus probe pTBB-2 and multiple flanking markers, including tyrosine hydroxylase (TH). Two-point linkage analysis using pTBB-2 and TH markers was consistent with linkage in 15 of 23 families, with the maximum single-family LOD score of +3.038 occurring at theta = 0. However, 8 of 23 families had negative LOD scores, with the values in 4 families being less than -2 at theta = 0, consistent with exclusion of linkage. Analysis with the HOMOG program was consistent with genetic heterogeneity (P < .0001). Multipoint linkage data using pTBB-2 and TH were also examined for evidence of heterogeneity. HOMOG analysis of multipoint LOD scores from 100 cM surrounding the H-ras-1 locus also supported heterogeneity (P < .001). In the 23 families with LQTS analyzed for linkage to the H-ras-1 locus on chromosome 11p15.5, 15 of 23 families had LOD scores consistent with linkage. The remaining 8 of 23 families had negative LOD scores, 4 of which were definitively excluded from linkage. Thus, genetic heterogeneity is definitively (P < .001) demonstrated for this disorder.
Question: What is the mode of inheritance of Romano Ward long QT syndrome? | [
"autosomal dominant"
] | task469-cba86ce05a204a68b482e37ac0b18c9f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Slovak National Uprising (Slovak: Slovenske narodne povstanie, abbreviated SNP) or 1944 Uprising was an armed insurrection organized by the Slovak resistance movement during World War II. It was launched on 29 August 1944 from Banska Bystrica in an attempt to resist German troops that had occupied Slovak territory and to overthrow the collaborationist government of Jozef Tiso.
Question: What year did Slovak National Uprising start? | [
"29 august 1944"
] | task469-81feddead1bb465eba2f564852b230d7 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: ''Calling Hong Kong'' was the second single by Orange County pop punk band Supernova, released on 7'' by Goldenrod Records in 1993.
Question: Which singer-songwriter is Calling Hong Kong the fifth studio album of? | [
"supernova"
] | task469-1bca9a0571b1499dbb5fa65ce15f4bd8 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: There were 22,000 households of which 37.1% had children under the age of 18 living with them, 48.3% were Marriage living together, 12.7% had a female householder with no husband present, 5.1% had a male householder with no wife present, and 33.9% were non-families. 26.7% of all households were made up of individuals and 7.5% had someone living alone who was 65 years of age or older. The average household size was 2.70 and the average family size was 3.24.
Question: Which group for households is smaller: average family size or average household size? | [
"average household size"
] | task469-f5ce0f11336c48aa90cedaf615a41e8f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The film opens as Alice Melbourne and Judson Ellis arrive at a California Municipal Airport by taxi. Alighting from the cab they tip the driver generously, bribing him to not say anything to anyone about them. Alice and Judson check the departure sign for The Silver Queen, heading for Panama City, Panama, and seem excited and anxious.Also waiting for the same flight is Peggy Nolan, to whom a delivery of expensive flowers is made with a card thanking her for some favor. Peggy disdainfully tosses the card in the trash and gives the flowers to a woman selling cheap gardenias.Soon after, the flight gets ready to leave and we are introduced to Professor and Mrs. Spengler, an elderly couple, and Joe, the flight's co-pilot, who is immediately attracted to Alice. Mrs. Spengler is a domineering woman, but her husband seems content to be bossed around like a child.As they wait on the tarmac near the 'plane a car drives up and a well dressed man emerges with a young boy and another man. The boy is Tommy and he is being sent away with "Uncle" Pete until his father -- a mobster -- can follow later.As the passengers board, Bill, the pilot, receives word that they will be transporting an anarchist back to Panama, but he assures the group there is nothing to worry about since the man will be in custody during the flight. The prisoner is Vasquez, and is being accompanied by a bounty hunter named Crimp.After Larry the steward helps everyone get settled, the flight departs with its twelve souls aboard. Bill and Joe discuss plans for the layover and Joe indicates he has an interest in Alice. He goes back to the passenger compartment where beds have been made up and people are turning in for the night -- except for Crimp who plans to stay up and make sure Vasquez doesn't "go for a walk" -- thus cheating the hangman and himself out of $5,000.Pete tucks his young charge in for the night and helps him say his prayers (something Pete is unfamiliar with). Peggy comes up to the cockpit to visit with Bill, whose rudeness finally makes it clear that he wants nothing to do with her. When Alice rings for the steward, Joe takes the call and makes a play for her.Next morning the 'plane arrives for a refueling stop in Mexico and the passengers have breakfast. Joe continues to pursue Alice, under the assumption that she is Judson's secretary. Peggy makes another stab at getting Bill to warm to her and is rebuffed again. Then Pete tells her that her help isn't needed when she tries to get Tommy to drink his milk. Peggy's been "marked" as a loose woman by her fellow travelers who want nothing to do with her.Before boarding the 'plane a reporter confronts Judson and Alice and Joe learns that she is engaged to her "boss" and they are eloping.As the flight continues and heads into stormy weather the Professor discusses the methods by which a South American tribe of headhunters practice their craft. The conversation is interrupted by a news bulletin which recounts how Tommy's father has been killed. Peggy again tries to help with Tommy, saying "he needs a woman." But Pete is still being judgemental and answers "he needs a lady." Mrs. Spengler intervenes and comforts Tommy.As the storm they are flying through gets rougher, the passengers strap themselves into their seats and Crimp insists the pilots turn back. As the 'plane rocks back and forth a couple of metal cylinders break loose and crash through the back door. Tommy comes perilously close to going out the door when Llarry saves him and hands him to Pete. Just then the 'plane dips sharply and Larry is tossed out the door to his death. As Joe and Bill try to steady the 'plane Crimp tries to force them to turn back by waving his gun at them. In the struggle the gun goes off and is picked up by Vasquez.With a damaged engine the Silver Queen crashes, and all eleven on board survive. The next morning Joe and Bill admit to the professor that they were blown off
Question: who are all struggle to repair the damaged airliner? | [
"bill and joe"
] | task469-e3637ada049e46b1b0e0c1c9edeaf792 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Arnold of Selenhofen (c. 1095/1100 -- 24 June 1160) was the archbishop of Mainz from 1153 to his assassination in the benedictine abbey St. Jakob, where he took shelter from the raging crowd.
Question: Was the death of Arnold of Selenhofen an accident or suicide? | [
"assassination"
] | task469-74a07867a06144aaad8dc6173aedc37f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Mahjong, that favorite pastime of "old folks" in Shanghai, is finding a new audience among younger players, and many university students are becoming mad about this traditional Chinese game. Students at Fudan University have even formed a Mahjong club. This resurgence of the game, however, is not without its critics. Some people still associate the game with gambling and for many years Mahjong was banned in China. One critic, surnamed Meng, was quoted as saying, "Mahjong is a bad custom that will distract students from studies." But Yu Guangyuan, former vice-president of the Chinese Academy of Social Sciences , says Mahjong is a "healthy, scientific, friendly mind game." Mr. Yu's opinion seems to be shared by the majority of Chinese. They see the game as an activity that requires great concentration and intellectual skill. They also see the game as an important part of Chinese culture and a pastime that brings family and friends closer together. This Spring Festival many families will no doubt spend hours around the Mahjong table getting reacquainted with each other. For them, playing Mahjong is a way of spending quality family time. No one knows who invented Mahjong. Some say it was Confucius, others say the current form of the game was developed right here in Shanghai in the late19th century. It is certainly because of Shanghai that the game enjoys its worldwide popularity. It was brought to America in the 1920s and has since spread throughout Europe and other parts of Asia. There is now a World Championship of Mahjong which is held every year. This year's championship was held in Chongqing and attracted players from America, Europe and Russia, as well as students from Peking University, Tshinghua University and Nankai University. There was no prize money, but the players delighted in using their wits and their understanding of statistics and probability theory to defeat their clever opponents. Of course, Mahjong doesn't have to always be that intense. For young people it can be a way to relax and to socialize, a chance to get away from their computers and talk to other people face to face. So, this Spring Festival, why not get out the "old folks" tiles: it's good to be mad about Mahjong!
Question: What is the best title of the passage? | [
"mad about mahjong"
] | task469-293acb97ec04471bbb220c8e88c2fd5f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: To elucidate the phenotype, genotype, and MRI findings of Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and mutation carriers. The authors studied 40 members of nine unrelated Korean CADASIL families. After genetic analysis of Notch3, clinical and MRI findings were correlated in 27 mutation carriers. Notch3 mutation sites were C174R (one family, n = 3), R133C (one family, n = 3), R587C (one family, n = 1), R544C (two families, n = 5), and R75P (four families, n = 15). The clinical features were typical of CADASIL, but the frequency of migraine in the Korean population appears low. MRI abnormalities were found in 54% of the mutant carriers, the most common being white matter hyperintensities. The prevalence of lacunes and microbleeds increased with patient age. Anterior temporal areas were less often involved in subjects with R75P mutations than in those where mutations occurred in other sites (p = 0.02). Gradient echo imaging identified microbleedings in 33% of mutation carriers (64% of those with abnormal MRI), whereas diffusion-weighted MRI showed abnormal findings in only one patient. Neurologic disability was related to the number of lacunar infarcts and the lesion volume of white matter hyperintensities (p < 0.001) whereas MMSE score was related to the number of lacunar infarcts (p < 0.005). Although Korean cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) mutation carriers show similar clinical and MRI findings, these abnormalities appear less frequently than in other populations. Relatively frequent microbleedings on gradient echo imaging suggest that treatment should be individualized according to MRI findings. The novel mutation of R75P, not involving a cysteine residue, is related to less frequent involvement of the anterior temporal area, thus broadening the spectrum of CADASIL.
Question: Which amino acid residue appears mutated in most of the cases reported with cadasil syndrome? | [
"cysteine"
] | task469-08fdca310e7249ef836f28811fa26ca5 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: On July 24, 2017, Gasol re-signed with the Spurs. On December 20, 2017, he had 20 points and a season-high 17 rebounds in a 93-91 win over the Portland Trail Blazers. On December 23, 2017, he recorded his 10th career triple-double with 14 points, 11 rebounds and a season-high 10 assists in a 108-99 win over the Sacramento Kings. On December 26, 2017, in a 109-97 win over the Brooklyn Nets, Gasol collected his 10,817th rebound, moving him past Jack Sikma for 30th in league history. On January 26, 2018, in a 97-78 loss to the Philadelphia 76ers, Gasol became the 34th player in NBA history to play 40,000 career minutes. On March 25, 2018, he had 22 points on 10-of-15 shooting and grabbed 13 rebounds in a 106-103 loss to the Milwaukee Bucks.
Question: Did Gasol's team score more points against the Brooklyn Nets or the Milwaukee Bucks? | [
"brooklyn nets"
] | task469-c93f907f5c5040478efb075970bbe80f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Ian Syster and his two-month-old son drowned in December 2004 in Keimoes following a car accident.
Question: What was the cause of death of Ian Syster? | [
"accident"
] | task469-51dde85f5d7e450780eae230eb4b4850 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Opening narrationAn explanation that our knowledge of Venus is very incomplete and only by imagination can we glimpse the planet, but the producers of the film believe the heroic Soviet people will see the planet with their own eyes.Opening sceneThree soviet spaceships CCCP Sirius Vega and Capella approach Venus after completing a 200 million kilometer journey. Suddenly before anyone can react Capella is destroyed with all hands by a stray meteor. The crew of the Sirius are devastated by the news, and reflect on how close they came only to die within sight of their destination. A message received from Earth advises that a replacement for Capella is launching soon and will reach Venus in 4 monthsAlexi ( ) one of the crew from Sirius doesnt want to wait and suggests they modify the robot glider on Vega, so. Venus needs to be seen by human eyes. He explains if anything happens he will not call for help. His life is his, to do with as he desires.Mr Kern (Georgi Tejkh) On board Vega must have the final say on the launch. Rather than use the glider he recommends landing the two ships rather than wait for the spare ship from Earth, but first he has to check the figures for the safety margins. To do this he activates the ships robot JohnThe robot proposes a different plane. Three crew members go down in the glider, three more go down in the Sirius, leaving Vega in orbit manned by Masha (Kyunna Ignatova) Masha feels cheated by the plan but realizes it is the only way the mission can succeed As they plan to land a strange red light is seen through the cloud cover. They decide to try and land close to that position. It is decided the glider will go down first, and try and identify a good landing place. Sirius will followThe glider finds a location but as it drops the beacon to mark the spot for Sirius it is blown off course and heads for a dangerous landing in a swampy region. From orbit Sirius cant re-establish contact. Unsure what may have happened Sirius decides to land at the beacon and try and find the crew of the gliderThe Sirius lands successfully and begins testing the environment to see if they can go outside. Using an external microphone they listen to the sounds of Venus. At one point they hear what sounds like a womans voice singing. Understanding that little can be accomplished from the ship they decide to outside and explore. As Alexi explores away from the ship he is attacked by some strange tentacle creature. The other crew dont realize the danger and continue to check instruments for signs of the glider. They discover two distinct signals. One they suspect is the glider, and one that is moving should be JohnFinally the others realize Alexis situation and rescuing him from the plant like creature. The creature responds by first releasing Alexi then encloses itself in a protective shellIn the meantime Masha has confirmed the other crew is alive and has pin-pointed their location, approximately 32 kilometers away. The fact John is active proves crew members must have survived because hed been disassembled for the flight downAt the other landing site Kern, working with the partially completed robot search for parts of the robot to complete the job of assembly. One of the other crew is firing ant strange reptilian creatures that keep attacking Meanwhile the crew of Sirius have gotten their rover working and set off to help the crew of Vega. On the way they see a brontosaurs and stop to take a blood sample from the slow moving creature. While doing this, Masha confirms that the Vegas crew is moving towards the Sirius location.The crew from the Vega begin to feel ill and fevered, they are concerned that the rips in their suit may have allowed them to get sick from Venusians germs. The crews of the Sirius reach the shore of a large body of water and decide to cross it rather than go around. As they prepare to submerge they hear the same strange womans voice. Pausing to investigate, they find nothing and press onBack with the Vega crew they have been caught in a rain storm and John cautions that he may soon malfunction because of the water. Schebra (Yuri Sarantsev) Is
Question: Allan and Ivan leave who in orbit? | [
"masha"
] | task469-56377ea6b0b445e18eafab2cacb47e2b | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: A Fate Totally Worse than Death is a spoof horror novel for young adults by Paul Fleischman, published in 1995, in which a badly behaved clique of high school girls get their comeuppance.
Question: What year was A Fate Totally Worse than Death made? | [
"1995"
] | task469-c0fb2c40f01a44cd9d2dcd8dcec40699 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Since 2011, the mayor of Kvalsund is Ragnar Olsen, who represents the Labour Party.
Question: Who was in charge of Kvalsund? | [
"ragnar olsen"
] | task469-0271cb8e51c045d2b598fef4356aef53 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Men in Black are a secret law-enforcement agency that is responsible for policing the extraterrestrial life hidden on Earth, as well as protecting the world from any aliens who attempt to destroy/invade the planet.The film begins on LunarMax, a MiB prison situated on the moon. A one-armed criminal, a Boglodite named Boris the Animal, stages a jailbreak (along the way killing Obadiah Price, a fellow inmate he'd made a deal with). His intention is to rewrite history, with Agent K, the one who arrested and imprisoned him, being a major factor in his plan...On Earth, Agent K and his partner Agent J cover up an arrival of an alien spacecraft, and hear of the prison break. At a Chinese restaurant thats a local haunt for aliens, Agent K discovers Boris (who had previously gone to see Obadiah's son Jeffrey) and the two fight, with J joining in. K is upset that the alien he should have killed is out loose again; he deems it his own affair and forbids J to help him, suspending him. A puzzled J checks up on Boris: he appeared in 1969 to stop the prevention of the ArcNet Shield, a device that K deployed to protect the world from harm (but which killed off the Boglodites, as they can only survive by feeding off worlds). He managed to kill on 15 July 1969 an alien named Roman the Fabulous and on the following day... at this point O cuts him off and tells him not to investigate any further. That night, as K waits for Boris with a gun in his hand, he suddenly vanishes...The next morning, J discovers that he has a new partner, the liberated Agent AA, and that K has been dead for forty years (having been killed by Boris the Animal on 16th July 1969). O notices he is suffering from headaches and craves chocolate milk, which she explains are symptoms of time-fracture (aka the crime of interfering with history, which Obadiah Price was imprisoned for). At this point a Boglodite armada appears; J learns that there was nothing to hold them at bay, with no K to deploy the ArcNet. He theorizes that Boris went back in time to 1969 to kill K, thus changing history to what it was, and proposes to follow him; he heads to Jeffrey Price, who had provided Boris a time-jump device, and gets another one from him, and activates it by jumping off the Chrysler Building just as the Boglodites begin their assault...J arrives in 15 July 1969, with the intention to catch Boris as he is about to murder Roman the Fabulous. However, he is delayed from navigating the era of 1969 (most notably by an altercation with two racist cops), and gets there too late to stop Romans murder by 1969 Boris. He encounters 1969 Agent K, who subdues him and brings him to MiB headquarters. J tells K nothing, but when threatened with getting his memory erased he tells K part of the truth: he came from the future in pursuit of another time-traveler whos trying to change history.K and J follow a trail of clues to Andy Warhols Factory complex, where Warhol is revealed to be MiB Agent W. He notifies them of Griffin, an Arcanian being who has the ability to foresee all timelines and futures; Griffins planet was destroyed by the Boglodites, so he came to live on Earth and brought with him a device which will prevent the Boglodites from consuming the Earth. 1969 Boris arrives at the Factory in search of Griffin, who makes a quick exit with Boris in fast pursuit (to Js displeasure, although K doesnt seem to get too worried).J and K eventually track down Griffin at Shea Stadium, where he is foreseeing the future victory for the Mets baseball team. 1969 Boris appears and captures Griffin, but J and K are able to rescue Griffin, although Boris gets away. Griffin gives them the ArcNet and explains it can only work in zero gravity: K gets the idea to head to Cape Canaveral on 16th July 1969 (the day the Apollo 11 ship launched)
Question: What is needed to protect the Earth from the Boglodite invasion? | [
"arcnet"
] | task469-4b89f753a66e40e68de6c119f7c55b00 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: From the outside, the skin looks plain and simple, as you can see in Figure 16.5. But at a cellular level, theres nothing plain or simple about it. A single square inch of skin contains about 20 blood vessels, hundreds of sweat glands, and more than a thousand nerve endings. It also contains tens of thousands of pigment-producing cells. Clearly, there is much more to skin than meets the eye! For a dramatic introduction to the skin, watch this video: MEDIA Click image to the left or use the URL below. URL: The skin is only about 2 mm thick, or about as thick as the cover of a book. Although it is very thin, it consists of two distinct layers, called the epidermis and the dermis. You can see both layers and some of their structures in Figure 16.6. Refer to the figure as you read about the epidermis and dermis below. The epidermis is the outer layer of skin. It consists almost entirely of epithelial cells. There are no blood vessels, nerve endings, or glands in this skin layer. Nonetheless, this layer of skin is very active. It is constantly being renewed. How does this happen? 1. The cells at the bottom of the epidermis are always dividing by mitosis to form new cells. 2. The new cells gradually move up through the epidermis toward the surface of the body. As they move, they produce the tough, fibrous protein called keratin. 3. By the time the cells reach the surface, they have filled with keratin and died. On the surface, the dead cells form a protective, waterproof layer. 4. Dead cells are gradually shed from the surface of the epidermis. As they are shed, they are replaced by other dead cells that move up from below. The epidermis also contains cells called melanocytes. You can see a melanocyte in Figure 16.7. Melanocytes produce melanin. Melanin is a brown pigment that gives skin much of its color. Everyones skin has about the same number of melanocytes per square inch. However, the melanocytes of people with darker skin produce more melanin. The amount of melanin that is produced depends partly on your genes and partly on how much ultraviolet light strikes your skin. The more light you get, the more melanin your melanocytes produce. This explains why skin tans when its exposed to sunlight. The dermis is the inner layer of skin. It is made of tough connective tissue. The dermis is attached to the epidermis by fibers made of the protein collagen. The dermis is where most skin structures are located. Look again at Figure pain, pressure, and temperature. If you cut your skin and it bleeds, the cut has penetrated the dermis and damaged a blood vessel. The cut probably hurts as well because of the nerve endings in this skin layer. The dermis also contains hair follicles and two types of glands. You can see some of these structures in Figure 16.8. Hair follicles are structures where hairs originate. Each hair grows out of a follicle, passes up through the epidermis, and extends above the skin surface. Sebaceous glands are commonly called oil glands. They produce an oily substance called sebum. Sebum is secreted into hair follicles. Then it makes its way along the hair shaft to the surface of the skin. Sebum waterproofs the hair and skin and helps prevent them from drying out. Sweat glands produce the salty fluid known as sweat. Sweat contains excess water, salts, and other waste products. Each sweat gland has a duct that passes through the epidermis. Sweat travels from the gland through the duct and out through a pore on the surface of the skin. You couldnt survive without your skin. It has many important functions. In several ways, it helps maintain homeostasis. The main function of the skin is controlling what enters and leaves the body. It prevents the loss of too much water from the body. It also prevents bacteria and other microorganisms from entering the body. Melanin in the epidermis absorbs ultraviolet light. This prevents the light from reaching and damaging the dermis. The skin helps maintain a constant body temperature. It
Question: The outer layer of the skin contains | [
"melanocytes."
] | task469-25e5b4f95f054ae69592f34d85a0cae8 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Van Gogh Museum's Wheatfield with Crows was painted in July 1890, in the last weeks of van Gogh's life.
Question: What is the name of the place where Wheatfield with Crows can be found? | [
"van gogh museum"
] | task469-79167673de73480bbf4adec441b74779 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The limited availability of effective drugs causes difficulties in the management of multidrug-resistant tuberculosis (MDR-TB) and novel therapeutic agents are needed. Delamanid , a new nitro-hydro-imidazooxazole derivative, inhibits mycolic acid synthesis. This review covers the efficacy and safety of delamanid for MDR-TB. This paper reviews the pharmacological profile of delamanid and the results of clinical trials evaluating its efficacy for treating MDR-TB in combination with other anti-TB drugs. The drug's safety and tolerability profiles are also considered. Delamanid showed potent activity against drug-susceptible and -resistant Mycobacterium tuberculosis in both in vitro and in vivo studies. In clinical trials, the drug showed significant early bactericidal activity in pulmonary TB patients, and increased culture conversion after 2 months of treatment in combination with an optimized background regimen in MDR-TB patients. In addition, decreased mortality was observed in MDR-TB patients who received > 6 months of delamanid treatment. The drug was generally tolerable, but QT prolongation should be monitored carefully using electrocardiograms and potassium levels. Therefore, delamanid could be used as part of an appropriate combination regimen for pulmonary MDR-TB in adult patients when an effective treatment regimen cannot otherwise be composed for reasons of resistance or tolerability.
Question: Which disease can be treated with Delamanid? | [
"tuberculosis"
] | task469-c604f49ad84a4247bcc36cbc314e30dd | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Uranus (YOOR-uh-nuhs) is named for the Greek god of the sky. From Earth, Uranus is so faint that it was unnoticed by ancient observers. William Herschel first discovered the planet in 1781. Although Uranus is very large, it is extremely far away, about 2.8 billion km (1.8 billion mi) from the Sun. Light from the Sun takes about 2 hours and 40 minutes to reach Uranus. Uranus orbits the Sun once about every 84 Earth years. Uranus has a mass about 14 times the mass of Earth, but it is much less dense than Earth. Gravity at the surface of Uranus is weaker than on Earths surface, so if you were at the top of the clouds on Uranus, you would weigh about 10% less than what you weigh on Earth. Like Jupiter and Saturn, Uranus is composed mainly of hydrogen and helium, with an outer gas layer that gives way to liquid on the inside. Uranus has a higher percentage of icy materials, such as water, ammonia (NH3 ), and methane (CH4 ), than Jupiter and Saturn. When sunlight reflects off Uranus, clouds of methane filter out red light, giving the planet a blue-green color. There are bands of clouds in the atmosphere of Uranus, but they are hard to see in normal light, so the planet looks like a plain blue ball. Most of the planets in the solar system rotate on their axes in the same direction that they move around the Sun. Uranus, though, is tilted on its side, so its axis is almost parallel to its orbit. In other words, it rotates like a top that was turned so that it was spinning parallel to the floor. Scientists think that Uranus was probably knocked over by a collision with another planet-sized object billions of years ago. Uranus has a faint system of rings (Figure 1.1). The rings circle the planets equator, but because Uranus is tilted on its side, the rings are almost perpendicular to the planets orbit. This image from the Hubble Space Tele- scope shows the faint rings of Uranus. The planet is tilted on its side, so the rings are nearly vertical. Uranus has 27 known moons and all but a few of them are named for characters from the plays of William Shakespeare. The five biggest moons of Uranus Miranda, Ariel, Umbriel, Titania, and Oberon are shown in Figure 1.2. These Voyager 2 photos have been resized to show the relative sizes of the five main moons of Uranus. Click image to the left or use the URL below. URL:
Question: who first discovered uranus? | [
"william herschel"
] | task469-17e129eee0fb49c1a45ddefa7a0f4695 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: An old farmer lived on a farm with his young grandson. Each morning Grandpa was up early to read his Bhagavat Geeta. His grandson wanted to be just like him and tried to imitate him in every way he could. One day the grandson asked, "Grandpa! I try to read the Bhagavat Geeta just like you but I don't understand it, What good does reading the Bhagavat Geeta do?" The Grandfather quietly turned from putting coal in the stove and replied, "Take this coal basket down to the river and bring me back a basket of water." The boy did as he was told, but all the water leaked out before he got back to the house. The grandfather laughed and said, "You'll have to move a little faster next time," and sent him back to the river with the basket to try again. This time the boy ran faster, but again the same took place. He told his grandfather that it was impossible to carry water with a basket. The old man said, " You're just not trying hard enough," So the boy again dipped the basket into the river and ran hard, but when he reached his grandfather the basket was again empty. he said, "See Grandpa, it's useless!" "So you think it is useless?" The old man said, "Look at the basket." The boy looked at the basket and for the first time realized that the basket was different. It had been transformed from a dirty old coal basket into a clean one inside and outside. "You might not understand or remember everything, but when you read it, you will be changed, inside and out. That is the work of Krishna in our lives."
Question: What would the grandson like to do in the future? | [
"to read the bhagavat geeta."
] | task469-ae003563795c44f79aa638eb138cc241 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: September 1939. Mrs. Kay Miniver (Greer Garson) and her family live a comfortable life at a house called 'Starlings' in Belham, a fictional village outside London, England. The house has a large garden, with a private landing stage on the River Thames at which is moored a motorboat belonging to her devoted husband Clem (Walter Pidgeon), a successful architect. They have three children: the youngsters Toby and Judy (Christopher Severn and Clare Sandars) and an older son Vin (Richard Ney) at university. They have live-in staff: Gladys the housemaid (Brenda Forbes) and Ada the cook (Marie De Becker).As World War II looms, Vin comes down from university and meets Carol Beldon (Teresa Wright), granddaughter of Lady Beldon (Dame May Whitty) from nearby Beldon Hall. Despite initial disagreements (mainly contrasting Vin's idealistic attitude to class differences with Carol's practical altruism) they fall in love. Vin proposes to Carol in front of his family at home after his younger brother prods him to give a less romantic but more honest proposal.Several months later, as the war comes closer to home with the bombing of Great Brittan, Vin feels he must "do his bit" and enlists in the Royal Air Force, qualifying as a fighter pilot. He is posted to a base near to his parents' home and is able to signal his safe return from operations to his parents by cutting his engines briefly as he flies over the house. Together with other boat owners, Clem volunteers to take his motorboat to assist in the May-June 1940 Dunkirk evacuation.Early one morning, Kay unable to sleep as Clem is still away, wanders down to the landing stage. She is startled to discover a wounded German pilot (Helmut Dantine) hiding in her garden and he holds her at gunpoint. Demanding food and a coat, the pilot maniacally asserts that the Third Reich will mercilessly overcome its enemies. She feeds him, calmly disarms him and then calls the police. Soon after, Clem returns home, exhausted, from Dunkirk.Lady Beldon visits Kay to try and convince her to talk Vin out of marrying Carol on account of her granddaughter's comparative youth. Lady Beldon is unsuccessful and admits defeat when Kay reminds her that she, too, was young when she married her late husband. Lady Beldon concedes defeat and realises that she would be foolish to try and stop the marriage. Vin and Carol are married; Carol has now also become Mrs Miniver, and they return from their honeymoon in Scotland. A key theme is that she knows he is likely to be killed in action, but the short love will fill her life. Later, Kay and her family take refuge in their Anderson shelter in the garden during an air raid, and attempt to keep their minds off the frightening bombing by reading Alice's Adventures in Wonderland, which Clem refers to as a "lovely story" as they barely survive a bomb destroys parts of the house. They take the damage with nonchalance.At the annual village flower show, Lady Beldon silently disregards the judges' decision that her rose is the winner, instead announcing the entry of the local stationmaster, Mr. Ballard (Henry Travers), named the "Mrs. Miniver" rose, as the winner, with her own rose taking second prize. As air raid sirens sound and the villagers take refuge in the cellars of Beldon Hall, Kay and Carol drive Vin to join his squadron. On their journey home they witness fighter planes in a 'dogfight'. For safety, Kay stops the car and they see the German plane crash. Kay realises Carol has been wounded by shots from the plane and takes her back to 'Starlings'. She dies a few minutes after they reach home. Kay is devastated. When Vin returns from battle, he already knows the terrible news. Unexpectedly he is the survivor, and she the one who gives her life for England.The villagers assemble at the badly damaged church where their vicar (Henry Wilcoxon) affirms their determination in a powerful sermon:"We in this quiet corner of England have suffered the loss of friends very dear to us, some
Question: Where did Vin and Carol have their honeymoon? | [
"scotland"
] | task469-7ee13dc02c234062b095bb648b84fcc2 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Chronic myeloid leukemia (CML) is characterized by formation of a BCR-ABL fusion gene, usually as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 and 22. Recently the development of new fluorescence in-situ hybridization (FISH) techniques has allowed identification of unexpected deletions of the reciprocal translocation product, the derivative chromosome 9, in 10% to 15% of patients with CML. These deletions are large, span the translocation breakpoint, and occur at the same time as the Ph translocation. Such deletions therefore give rise to previously unsuspected molecular heterogeneity from the very beginning of this disease, and there is mounting evidence for similar deletions associated with other translocations. Several studies have demonstrated that CML patients who carry derivative chromosome 9 deletions exhibit a more rapid progression to blast crisis and a shorter survival. Deletion status is independent of, and more powerful than, the Sokal and Hasford/European prognostic scoring systems. The poor prognosis associated with deletions is seen in patients treated with hydroxyurea or interferon, and preliminary evidence suggests that patients with deletions may also have a worse outcome than nondeleted patients following stem cell transplantation or treatment with imatinib. Poor outcome cannot be attributed to loss of the reciprocal ABL-BCR fusion gene expression alone, and is likely to reflect loss of one or more critical genes within the deleted region. The molecular heterogeneity associated with the Philadelphia translocation provides a new paradigm with potential relevance to all malignancies associated with reciprocal chromosomal translocations and/or fusion gene formation.
Question: Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation? | [
"the bcr/abl gene fusion",
"abl/bcr fusion"
] | task469-e399c979ec2840cab1229c8a3f684a6c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In an endothermic reaction, it takes more energy to break bonds in the reactants than is released when new bonds form in the products. The word "endothermic" literally means "taking in heat." A constant input of energy, often in the form of heat, is needed in an endothermic reaction. Not enough energy is released when products form to break more bonds in the reactants. Additional energy is needed to keep the reaction going. The general equation for an endothermic reaction is: Reactants + Energy ! Products In many endothermic reactions, heat is absorbed from the surroundings. As a result, the temperature drops. The drop in temperature may be great enough to cause liquid products to freeze. Thats what happens in the endothermic reaction at this URL: One of the most important endothermic reactions is photosynthesis. In this reaction, plants synthesize glucose (C6 H12 O6 ) from carbon dioxide (CO2 ) and water (H2 O). They also release oxygen (O2 ). The energy for photo- synthesis comes from light (see Figure 8.12). Without light energy, photosynthesis cannot occur. The chemical equation for photosynthesis is: 6CO2 + 6H2 O ! C6 H12 O6 + 6O2 In an exothermic reaction, it takes less energy to break bonds in the reactants than is released when new bonds form in the products. The word "exothermic" literally means "turning out heat." Energy, often in the form of heat, is released as an exothermic reaction occurs. The general equation for an exothermic reaction is: Reactants ! Products + Energy If the energy is released as heat, an exothermic reaction results in a rise in temperature. Thats what happens in the exothermic reaction at the URL below. Combustion reactions are examples of exothermic reactions. When substances burn, they usually give off energy as heat and light. Look at the big bonfire in Figure 8.13. You can see the light energy it is giving off. If you were standing near the fire, you would also feel its heat. Whether a reaction absorbs energy or releases energy, there is no overall change in the amount of energy. Energy cannot be created or destroyed. This is the law of conservation of energy. Energy can change form for example, from electricity to light but the same amount of energy always remains. If energy cannot be destroyed, what happens to the energy that is absorbed in an endothermic reaction? The energy is stored in the chemical bonds of the products. This form of energy is called chemical energy. In an endothermic reaction, the products have more stored chemical energy than the reactants. In an exothermic reaction, the opposite is true. The products have less stored chemical energy than the reactants. The excess energy in the reactants is released to the surroundings when the reaction occurs. The graphs in Figure 8.14 show the chemical energy of reactants and products in each type of reaction. All chemical reactions, even exothermic reactions, need a certain amount of energy to get started. This energy is called activation energy. For example, activation energy is needed to start a car. Turning the key causes a spark that activates the burning of gasoline in the engine. The combustion of gas wont occur without the spark of energy to begin the reaction. Why is activation energy needed? A reaction wont occur unless atoms or molecules of reactants come together. This happens only if the particles are moving, and movement takes energy. Often, reactants have to overcome forces that push them apart. This takes energy as well. Still more energy is needed to start breaking bonds in reactants. The graphs in Figure 8.15 show the changes in energy in endothermic and exothermic reactions. Both reactions need the same amount of activation energy in order to begin. You have probably used activation energy to start a chemical reaction. For example, if youve ever used a match to light a campfire, then you provided the activation energy needed to start a combustion reaction. Combustion is exothermic. Once a fire starts to burn, it releases enough energy to activate the next reaction, and the next, and so on. However, wood will not burst
Question: energy needed to start a reaction | [
"activation energy"
] | task469-13be619d636b45f98731a26124b37e5a | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Born in Brognard, France, in the department of Doubs near Montbeliard, Pierre Widmer was raised in a Mennonite family.
Question: Where did Pierre Widmer live when he died? | [
"montbéliard"
] | task469-3cb29711dca443bbbe423bd2cccfc318 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Spleen tyrosine kinase (Syk), a key mediator of immunoreceptor signaling in inflammatory cells, is essential for immune complex-mediated signal transduction initiated by activated receptors for immunoglobulin G. In collagen-induced arthritis, R788/R406, a novel and potent small molecule Syk inhibitor suppressed clinical arthritis, bone erosions, pannus formation, and synovitis. Serum anti-collagen type II antibody levels were unaltered, while the half-life of exogenous antibody was extended when co-administered with R406. Expression of the targeted kinase (Syk) in synovial tissue correlated with the joint level of inflammatory cell infiltrates and was virtually undetectable in treated rats. Syk inhibition suppressed synovial cytokines and cartilage oligomeric matrix protein (COMP) in serum, suggesting a sensitive and reliable biomarker for R406 activity. These results highlight the role of activating Fcgamma receptors in inflammatory synovitis and suggest that interruption of the signaling cascade with a novel Syk inhibitor may be a useful addition to immunosuppressive disease-modifying anti-rheumatic drugs currently used in the treatment of human autoimmune diseases such as rheumatoid arthritis.
Question: Which enzyme is inhibited by a drug fostamatinib? | [
"spleen tyrosine kinase"
] | task469-3139185564094ad78a77c43a87113896 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Kolding Stadion, nicknamed rneborgen by the local team's fanclub after Kolding FC's impressive home record of the 2005 autumn-season (just one loss).
Question: What team uses Kolding Stadion? | [
"kolding fc"
] | task469-66c6bc58347c4eae8db77ec8cb63efda | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Spanish policy evolved to make peace with the Chichimecas had four components: negotiation of peace agreements, welcoming conversion, instead of forcing conversion to Catholicism with missionaries, encouraging native allies to settle the frontier to serve as examples and role models, and providing food, other commodities, and tools to potentially hostile natives. This established the pattern of Spanish policy for assimilating natives on their northern frontier. The principal components of the policy of purchase for peace would continue for nearly three centuries and would not be as successful, as later threats from hostile natives such as Apaches and Comanches would demonstrate and as Spaniards would still value any means to riches and break treaties with natives. After the Chichimeca War, the Purchase for Peace Program gradually corrupted. Many Spanish Loyalist resented the defeat. The Spanish loyalist attempted enslavement for mining and agricultural labor, enforced harsh working conditions to the lower social classes, and implemented extremely oppressive political and economic systems against the native and mestizo populations of Mexico. The Catholic Church sustained the Mexican Inquisition torturing and killing hundreds of people who did not convert to Catholicism. The Mexican Inquisition was first abolished by decree in 1812. However, political tensions and chaos led to something of its return between 1813 and 1820. It was abolished in 1820. This societal tension during this period contributed to the initiation of the Mexican War of Independence; which started in 1810 and ended in 1821.
Question: Which happened first, the Mexican War of Independence, or the decree to abolish the Mexican Inquisition? | [
"mexican war of independence"
] | task469-2e7a0506be994da385cdc32f23718984 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Lacus Oblivionis (latin for ''Lake of Forgetfulness'') is a small lunar mare on the surface of the Moon.
Question: The astronomical body that Lacus Oblivionis is on is what? | [
"moon"
] | task469-213a061d94304ce2a4650b116794b215 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Chiang Wei-shui (February 8, 1891--August 5, 1931) was a founder of the Taiwanese Cultural Association and the Taiwanese People's Party.
Question: The birth date of Chiang Wei-shui is what? | [
"1891"
] | task469-33743e41b57246d0a75f46b97b5c7bbd | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Recurrent syncope, malignant ventricular arrhythmias, and sudden death are complications of the long QT syndrome (LQTS). Two well-known syndromes with long QT intervals are known. The Jervell and Lange-Nielsen syndrome (JLNS) is characterized by prolongation of the QT interval, deafness, and autosomal-recessive inheritance, and the Romano-Ward syndrome is characterized by a prolonged QT interval, autosomal-dominant inheritance, and no deafness. In the present study assessment was performed of the diagnostic importance of the ventricular derepolarization parameters, clinical features, and prevalence of JLNS among 132 children with congenital hearing loss (CHL). In the CHL group the mean QT, QTc, JT, and JTc intervals and the dispersion values (QT-d, JT-d, QTc-d, and JTc-d) were significantly longer than those of control subjects (n = 96) (P < 0.05). Patients with CHL and JLNS (n = 5) had significantly longer mean values of QT, QTc, JT, and JTc intervals and dispersion values than those of CHL without JLNS (n = 127) and control subjects (P < 0.05). The results suggest that assessment of ventricular derepolarization parameters in children with CHL will be helpful in the early detection of JLNS because infants with CHL cannot accurately describe the symptoms of syncope.
Question: What is the mode of inheritance of Romano Ward long QT syndrome? | [
"autosomal dominant",
"autosomal-dominant"
] | task469-b99f283a1a8d4c1891563650d1177497 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Tsunami are deadly ocean waves from the sharp jolt of an undersea earthquake. Less frequently, these waves can be generated by other shocks to the sea, like a meteorite impact. Fortunately, few undersea earthquakes, and even fewer meteorite impacts, generate tsunami. Tsunami waves have small wave heights relative to their long wavelengths, so they are usually unnoticed at sea. When traveling up a slope onto a shoreline, the wave is pushed upward. As with wind waves, the speed of the bottom of the wave is slowed by friction. This causes the wavelength to decrease and the wave to become unstable. These factors can create an enormous and deadly wave. Landslides, meteorite impacts, or any other jolt to ocean water may form a tsunami. Tsunami can travel at speeds of 800 kilometers per hour (500 miles per hour). Since tsunami are long-wavelength waves, a long time can pass between crests or troughs. Any part of the wave can make landfall first. In 1755 in Lisbon, Portugal, a tsunami trough hit land first. A large offshore earthquake did a great deal of damage on land. People rushed out to the open space of the shore. Once there, they discovered that the water was flowing seaward fast and some of them went out to observe. What do you think happened next? The people on the open beach drowned when the crest of the wave came up the beach. Large tsunami in the Indian Ocean and more recently Japan have killed hundreds of thousands of people in recent years. The west coast is vulnerable to tsunami since it sits on the Pacific Ring of Fire. Scientists are trying to learn everything they can about predicting tsunamis before a massive one strikes a little closer to home. Although most places around the Indian Ocean did not have warning systems in 2005, there is a tsunami warning system in that region now. Tsunami warning systems have been placed in most locations where tsunami are possible. Click image to the left or use the URL below. URL:
Question: tsunami can travel at speeds of | [
"800 kilometers per hour"
] | task469-64a370ebfe9b4379bf31d9c4d4278819 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Set in the Australian outback in the 1880s, the movie follows the series of events following the horrific rape and murder of the Hopkins family, allegedly committed by the infamous Burns brothers gang.The film opens in a brothel during a violent gunfight between the police and Charlie Burns' (Guy Pearce) gang, which ends with the deaths of all of the gang members except for Charlie and his younger brother Mikey. Captain Stanley (Ray Winstone) proposes to Charlie: he and Mikey can go free of the crimes they have committed if Charlie kills his older brother, Arthur (Danny Huston). Arthur is a mercurial psychopath who has become something of a legend and is so vicious that the Aboriginal tribes refer to him as "The Dog Man" and both the police and the Aboriginals refuse to go near his camp. Captain Stanley muses that perhaps the bounty hunters will kill Arthur in time and then states his intention to civilize the harsh Australian wilderness by bringing Arthur to justice and using Mikey as leverage. Charlie has nine days to find and kill Arthur, or else Mikey will be hanged from the gallows on Christmas Day.We discover why Captain Stanley is intent on taming Australia: he has been forced to move there with his delicate wife, Martha Stanley (Emily Watson), and apparently wants to make it an appropriate place for them to live. The Stanleys were also friends of the Hopkins family, leading Martha to have nightmares about her dead friends and the unborn child one of them is revealed to have carried. Word spreads of Stanley's deal with Charlie, primarily from Stanley's corrupt subordinate, Sergeant Lawrence (Robert Morgan), causing disgust among the townspeople.Shortly thereafter, Eden Fletcher (David Wenham), for whom Captain Stanley works, orders that Mikey be given one hundred lashes as punishment for the rape and murder of the Hopkins family. Stanley is aghast at this, not only because he believes that Mikey is innocent and the flogging will surely kill him, but because it would also break his deal with Charlie and thus put him and his wife in grave danger. Stanley sends Sergeant Lawrence away with tracker Jacko (David Gulpillil) and other men to "investigate" the reported slaying of Dan O'Riley by a group of Aborigines. Captain Stanley attempts to defend Mikey by gunpoint from the bloodthirsty townspeople, but is overruled once Martha arrives, insisting on revenge for her dead friends. Mikey is then brutally flogged, and horrifically wounded. The formerly excited townspeople slowly become disgusted and Martha faints at the ghastly display. After 40 lashes, Mikey has collapsed and the whip is soaked with blood. Captain Stanley grabs the whip and throws it at Fletcher, staining his face and suit with blood, who in turn fires Stanley.Meanwhile, Charlie rides a great distance in search of Arthur, drinking and apparently reflecting on what he will do. Along the way, he encounters an inebriated old man named Jellon Lamb (John Hurt). In the course of conversation, Charlie realizes that Lamb is a bounty hunter in pursuit of the Burns brothers and knocks him out. Later on, after sleeping on a rock bed, Charlie awakes and, before he can gather what's going on, is speared in the chest by a group of Aboriginal men standing over him. Seconds later a gunshot is heard and the head of the man who threw the spear explodes. Charlie then passes out.Charlie wakes up in the camp of his brother Arthur, which is located in caves among desolate mountains. Arthur's gang consists of Samuel Stoat (Tom Budge), who shot the Aboriginal man who had speared Charlie; a woman named Queenie (Leah Purcell) who tends to Charlie's wound; and a muscular Aboriginal man called Two-Bob (Tom E. Lewis). As he recovers from his wounds, Charlie has several opportunities to kill his brother, but does not. Not too far away from Arthur's camp, Sergeant Lawrence and his men have found and butchered a group of Aborigines. Arthur and Two-Bob find Lawrence's group while they sleep, ostensibly to get a horse for Charlie, and proceed to kill Jacko and Sergeant Lawrence. Before Arthur stomps Lawrence
Question: What does Captain Stanley throw at Fletcher leaving bloodstains? | [
"the whip"
] | task469-2e1b791d27614670a9296be31cf9cacd | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The 2012 Michoacan murder of photographers concerns two Mexican freelance photographers, Arturo Barajas Lopez (1966? - 19 August 2012) and Jose Antonio Aguilar Mota (1986? - 19 August 2012), who were kidnapped on 16 August 2012 and found murdered in Ecuandureo, Michoacan, Mexico.
Question: The point in time of 2012 Michoacan murder of photographers was when? | [
"19 august 2012"
] | task469-d9b533a926e34dfa8e80c2845c81dc77 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The genetic information of the cell, or DNA, is stored in the nucleus. During mitosis, two nuclei (plural for nucleus) must form, so that one nucleus can be in each of the new cells after the cell divides. In order to create two genetically identical nuclei, DNA inside of the nucleus must be copied or replicated. This occurs during the S phase of the cell cycle. During mitosis, the copied DNA is divided into two complete sets, so that after cytokinesis, each cell has a complete set of genetic instructions. To begin mitosis, the DNA in the nucleus wraps around proteins to form chromosomes. Each organism has a unique number of chromosomes. In human cells, our DNA is divided up into 23 pairs of chromosomes. Replicated DNA forms a chromosome made from two identical sister chromatids, forming an "X" shaped molecule ( Figure 1.1). The two chromatids are held together on the chromosome by the centromere. The centromere is also where spindle fiber microtubules attach during mitosis. The spindles separate sister chromatids from each other. During mitosis, the two sister chromatids must be divided. This is a precise process that has four individual phases to it. After the sister chromatids separate, each separate chromatid is now known as a chromosome. Each resulting chromosome is made of DNA from just one chromatid. So, each chromosome after this separation is made of "1/2 of the X." Through this process, each daughter cell receives one copy of each chromosome. The four phases of mitosis are prophase, metaphase, anaphase and telophase ( Figure 1.2). 1. Prophase: The chromatin, which is unwound DNA, condenses forming chromosomes. The DNA becomes so tightly wound that you can see them under a microscope. The membrane around the nucleus, called the nuclear envelope, disappears. Spindles also form and attach to chromosomes to help them move. 2. Metaphase: The chromosomes line up in the center, or the equator, of the cell. The chromosomes line up in a row, one on top of the next. 3. Anaphase: The two sister chromatids of each chromosome separate as the spindles pull the chromatids apart, resulting in two sets of identical chromosomes. 4. Telophase: The spindle dissolves and nuclear envelopes form around the chromosomes in both cells. An overview of the cell cycle and mito- sis: during prophase the chromosomes condense, during metaphase the chromo- somes line up, during anaphase the sister chromatids are pulled to opposite sides of the cell, and during telophase the nuclear envelope forms. This is a representation of dividing plant cells. Cell division in plant cells differs slightly from animal cells as a cell wall must form. Note that most of the cells are in interphase. Can you find examples of the different stages of mitosis?
Question: when do spindles form and attach to chromosomes? | [
"prophase"
] | task469-1fb35a55a0ff46ca889cef6d90a0b843 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: We all love festivals. But since culture develops differently in many places, some festivals are, to us, very strange. Let's take a look at some unique festivals around the world. Cheese Rolling Festival (England) The festival started in the 15thcentury in May. When a round cheese is rolled, competitors run down the hill and try to catch it before it reaches the bottom. As the cheese can reach speeds of up to 112 km/h, it's rare that someone catches the cheese. First to the bottom wins the cheese. But running down a very steep hill behind a cheese can be dangerous. Eight people were injured in 1992. Roswell UFO festival (New Mexico, US) The Roswell UFO festival celebrates the anniversary of the "Roswell Incident", when a UFO was said to have crashed nearby. Every year in July, experts, authors, researches and lecturers come to discuss the incident. The celebration also includes an alien parade, an alien costume contest, and an alien hot air balloon ride. Hemingway Days (Florida, US) This festival has normal stuff (,) like short-story readings and exhibits about the author. But the highlight of the festival is definitely the Hemingway look alike contest. Imagine walking into a bar and being greeted by 20 middle-aged men who all look alike: stocky with thick white beards. The festival takes place in mid-July every year.
Question: Which festival takes place in mid-July every year? | [
"hemingway days."
] | task469-8635f686d0ad48c4b2c888befe9023ec | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The general Chinese history texts on the Ming Dynasty, including the Mingdai Shi and the Mingshi, briefly mention Cao Qin's failed coup of 1461. Cao Qin's coup and the events leading up to it were covered in Gao Dai's Hong you lu of 1573, Jiao Hong's Guochao Xianzheng lu of 1594-1616, the Huang Ming shi gai of 1632 and the Mingshi jishi benmo of 1658. Li Xian also wrote about Cao Jixiang's career in his "Cao Jixiang zhi bian," featured in the Huang Ming mingchen jingji lu that was edited by Huang Xun in 1551.
Question: What happened first: Cao Qin's failed coup or Gao Dai's Hong you lu? | [
"cao qin's failed coup"
] | task469-7bf4b254e6eb4992b160c7635abcc5de | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: An alloy is a mixture of a metal with one or more other elements. The other elements may be metals, nonmetals, or both. An alloy is formed by melting a metal and dissolving the other elements in it. The molten solution is then allowed to cool and harden. Alloys generally have more useful properties than pure metals. Several examples of alloys are described and pictured below. If you have braces on your teeth, you might even have this alloy in your mouth! Click image to the left or use the URL below. URL: Most metal objects are made of alloys rather than pure metals. Objects made of four different alloys are shown in the Figure 1.1. Brass saxophone: Brass is an alloy of copper and zinc. It is softer than bronze and easier to shape. Its also very shiny. Notice the curved pieces in this shiny brass saxophone. Brass is used for shap- ing many other curved objects, such as doorknobs and plumbing fixtures. Stain- less steel sink: Stainless steel is a type of steel that contains nickel and chromium in addition to carbon and iron. It is shiny, strong, and resistant to rusting. This makes it useful for sinks, eating utensils, and other objects that are exposed to wa- ter. "Gold" bracelet: Pure gold is relatively soft, so it is rarely used for jewelry. Most "gold" jewelry is actually made of an alloy of gold, copper and silver. Bronze statue: Bronze was the first alloy ever made. The earliest bronze dates back many thou- sands of years. Bronze is a mixture of copper and tin. Both copper and tin are relatively soft metals, but mixed together in bronze they are much harder. Bronze has been used for statues, coins, and other objects. Q: Sterling silver is an alloy that is used to make fine jewelry. What elements do you think sterling silver contains? What properties might sterling silver have that make it more useful than pure silver? A: Most sterling silver is about 93 percent silver and about 7 percent copper. Sterling silver is harder and stronger than pure silver, while retaining the malleability and luster of pure silver.
Question: the first alloy ever made was | [
"bronze."
] | task469-fb1de0a07a724fd79ff78555c1a9bb23 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Fear plays no part in this latest problem."I'm not afraid I'll lose my children.I won't lose my children. We live together, and nothing, nothing," she repeats, her voice rising when speaking to John's lawyer, "will stop me from being with my children. A law? Yeah, right. Don't disturb me when it comes to my children. You are never going to win. If John wants to see them, I cannot stop him. He's their father--I want them to see him! However, his visit in his present condition will disturb the children's stable life." John, who has spent much of his time in California, recently, has only hired a house for himself in Pennsylvania, according to his lawyer. "If he'd like to stick to a regular life, I'd be more than happy to do that," Jane says. "The best thing for any child of a divorced parent is a stable life. I want nothing more than for him to set up a stable life for himself, so that he can be part of making our children's lives more stable. " While matters of money and care won't be settled for weeks, Jane hardly puts her life on hold. Last week the ABC network announced that Jane would return with her own show, Twist of Jane, in which she gives advice to other moms.Jane and her eight children will also return to ABC in a series of Jane Plus 8 specials showing them on various adventures.It's a rest for Jane, who insists that she needs her new,busy life to provide for her family."I have to lead such a life, and I'm thankful that I've built it to the top where now I can support my children."she says. And whether a bellicose dance judge or a bellicose former wife, Jane plans to keep on facing attacks on her. "Some people try to knock me down--only to make me more fierce,more protective,more determined to do better,"she says."Go ahead, take me on. This will just make me stronger."
Question: Which word can best describe Jane? | [
"determined."
] | task469-c70009a7c2b5499ca8ac55ed18cb01e4 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: After periods with Shamrock Rovers, Shelbourne and University College Dublin A.F.C., O Snodaigh was a squad member of the successful Bray Wanderers side that won the 1989-90 FAI Cup in at Lansdowne Road with a 3-0 victory against St Francis, lost in the European Cup Winners Cup tie against Trabzonspor, and finished runners-up in the 1990-91 League of Ireland First Division. That same year he was a central member of Wanderers reserve side that finished runners-up in the League of Ireland B Division. He won the B team player of the year award in 1990 and was a member of the first team that lost the LFA President's Cup final 3-1 against Dundalk. In time he left Bray and became a member of Leinster Senior League side Pegasus where, over a seven-year period, he was a member of their FAI Intermediate Cup winning team in 1992 against Bluebell United, top scorer in 1996/7, selected for the Leinster Senior League selection team in 1992, was captain of the side that got relegated from the senior division in 1997 following a defeat away to Bluebell and played in every position for the side except goalkeeper.
Question: Which team won the European Winners Cup, Trabzonspor or the Bray Wanderers? | [
"trabzonspor"
] | task469-353ccfec6d1a4b43b4be14a48610275b | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Freshwater below Earths surface is called groundwater. The water infiltrates, or seeps down into, the ground from the surface. How does this happen? And where does the water go? Water infiltrates the ground because soil and rock are porous. Between the grains are pores, or tiny holes. Since water can move through this rock it is permeable. Eventually, the water reaches a layer of rock that is not porous and so is impermeable. Water stops moving downward when it reaches this layer of rock. Look at the diagram in Figure 13.11. It shows two layers of porous rock. The top layer is not saturated; it is not full of water. The next layer is saturated. The water in this layer has nowhere else to go. It cannot seep any deeper into the ground because the rock below it is impermeable. The top of the saturated rock layer in Figure 13.11 is called the water table. The water table isnt like a real table. It doesnt remain firmly in one place. Instead, it rises or falls, depending on how much water seeps down from the surface. The water table is higher when there is a lot of rain and lower when the weather is dry. An underground layer of rock that is saturated with groundwater is called an aquifer. A diagram of an aquifer is shown in Figure 13.12. Aquifers are generally found in porous rock, such as sandstone. Water infiltrates the aquifer from the surface. The water that enters the aquifer is called recharge. Most land areas have aquifers beneath them. Many aquifers are used by people for freshwater. The closer to the surface an aquifer is, the easier it is to get the water. However, an aquifer close to the surface is also more likely to become polluted. Pollutants can seep down through porous rock in recharge water. An aquifer that is used by people may not be recharged as quickly as its water is removed. The water table may lower and the aquifer may even run dry. If this happens, the ground above the aquifer may sink. This is likely to damage any homes or other structures built above the aquifer. One of the biggest aquifers in the world is the Ogallala aquifer. As you can see from Figure 13.13, this aquifer lies beneath parts of eight U.S. states. It covers a total area of 451,000 square kilometers (174,000 square miles). In some places, it is less than a meter deep. In other places, it is hundreds of meters deep. The Ogallala aquifer is an important source of freshwater in the American Midwest. This is a major farming area, and much of the water is used to irrigate crops. The water in this aquifer is being used up ten times faster than it is recharged. If this continues, what might happen to the Ogallala aquifer? The top of an aquifer may be high enough in some places to meet the surface of the ground. This often happens on a slope. The water flows out of the ground and creates a spring. A spring may be just a tiny trickle, or it may be a big gush of water. One of the largest springs in the world is Big Spring in Missouri, seen in Figure 13.14. Water flowing out of the ground at a spring may flow downhill and enter a stream. Thats what happens to the water that flows out of Big Spring in Missouri. If the water from a spring cant flow downhill, it may spread out to form a pond or lake instead. Lake George in New York State, which is pictured in Figure 13.15, is a spring-fed lake. The lake basin was carved by a glacier. Some springs have water that contains minerals. Groundwater dissolves minerals out of the rock as it seeps through the pores. The water in some springs is hot because it is heated by hot magma. Many hot springs are also mineral springs. Thats because hot water can dissolve more minerals than cold water. Grand Prismatic Spring, shown in Figure 13.16, is a hot mineral spring. Dissolved minerals give its water a bright blue color. The edge of the spring is
Question: Water in a spring comes from a | [
"layer of rock."
] | task469-a6127b9a7a5b481caff13bca158b69b5 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Arnaud Berquin (September 1747 -- 21 December 1791) was a French children's author.
Question: What is the language of Arnaud Berquin? | [
"french"
] | task469-e40e547a2a544cc585dc60e5bb788c1a | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Double homeobox 4 (DUX4) is a candidate disease gene for facioscapulohumeral dystrophy (FSHD), one of the most common muscular dystrophies characterized by progressive skeletal muscle degeneration. Despite great strides in understanding precise genetics of FSHD, the molecular pathophysiology of the disease remains unclear. One of the major limitations has been the availability of appropriate molecular tools to study DUX4 protein. In the present study, we report the development of five new monoclonal antibodies targeted against the N- and C-termini of human DUX4, and characterize their reactivity using Western blot and immunofluorescence staining. Additionally, we show that expression of the canonical full coding DUX4 induces cell death in human primary muscle cells, whereas the expression of a shorter splice form of DUX4 results in no such toxicity. Immunostaining with these new antibodies reveals a differential effect of two DUX4 isoforms on human muscle cells. These antibodies will provide an excellent tool for investigating the role of DUX4 in FSHD pathogenesis.
Question: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4? | [
"fshd",
"facioscapulohumeral dystrophy"
] | task469-eb0948b2cbc74164b1cc315b406ecab7 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: American video game designer Roger Dearly (Jeff Daniels) lives with his pet dalmatian, Pongo, in London. One day, Pongo sets his eyes on a beautiful female dalmatian named Perdita. After a frantic chase through the streets and into St. James's Park, Roger and Pongo discover that Perdita likes Pongo. Her owner, Anita Campbell-Green (Joely Richardson), falls in love with Roger when they meet. After they both end up falling into the lake as a result of their dogs, they return to Roger's home, and Anita accepts his proposal. They get married along with Perdita and Pongo. Anita works as a fashion designer at the House of de Vil. Her boss, the pampered and very glamorous Cruella de Vil (Glenn Close) has a deep passion for fur, going so far as to have a taxidermist, Mr. Skinner, skin a white tiger at the London Zoo to make into a rug for her. Anita, inspired by her dalmatian, designs a coat made with spotted fur. Cruella is intrigued by the idea of making garments out of actual dalmatians and finds it amusing that it would seem as if she was wearing Anita's dog. Anita soon discovers that Perdita is pregnant, and is then informed that she is too, much to her shock. Some time later, Cruella visits their home, and expresses contempt upon meeting Roger. Her initial disgust at them having a baby turns to excitement when she finds out Perdita is expecting too. Several weeks later, she returns when a litter of 15 puppies are born and offers Roger and Anita 7,500 for them, but they refuse. She dismisses Anita and vows revenge against her and Roger. She has her henchmen, Jasper and Horace (Hugh Laurie and Mark Williams) break into their home and steal the puppies while Roger and Anita are gone for a walk at the park taking Pongo and Perdita with them. Along with 84 others that were previously stolen, they deliver them to her ancient country estate, De Vil Mansion. She also hires Mr. Skinner to kill and skin them to create her coat. With the family devastated at the loss of their puppies, Pongo uses the Twilight bark to carry the message via the dogs and animals of London, while Roger and Anita notify the Metropolitan Police Service. A dog who had witnessed the stolen puppies follows Jasper and Horace to the mansion, and finds all of them inside before helping them escape under the duo's noses. They make their way to a nearby farm, where they are later joined by Pongo and Perdita. Cruella arrives at the mansion and soon discovers what has happened. Furious, she decides to carry out the job herself, whilst Jasper and Horace attempt to search for them also. After several mishaps, Jasper and Horace discover nearby police on the hunt for Cruella and her henchmen and hand themselves in, joining Mr. Skinner who was beaten earlier while trying to kill Lucky, who had been left behind. Meanwhile, Cruella tracks the puppies to the farm where they are hiding and tries to retrieve them. However, they outwit her and cause her to fall into a vat of molasses and get thrown through a window into a pigpen. Shortly after, the fleeing dalmatians (including Lucky) are found and sent home via the Suffolk Constabulary, while those looking for Cruella arrive at the farm to arrest her. In the police van, she belittles Jasper, Horace, and Skinner for their incompetence before they are sprayed by a skunk which she had mistaken for her bag. Pongo, Perdita, and their puppies are reunited with Roger and Anita. After being informed that the remaining 84 puppies have no home to go to since they have not been claimed, they decide to adopt them, bringing the total to 101. Roger designs a successful video game featuring dalmatian puppies as the protagonists and Cruella as the villain, and they move to the English countryside with their millions.
Question: Who plays Roger? | [
"jeff daniels"
] | task469-fbb390dfd27046c5a59e1853da3380a3 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Variant histone H2AZ-containing nucleosomes are involved in the regulation of gene expression. In Saccharomyces cerevisiae, chromatin deposition of histone H2AZ is mediated by the fourteen-subunit SWR1 complex, which catalyzes ATP-dependent exchange of nucleosomal histone H2A for H2AZ. Previous work defined the role of seven SWR1 subunits (Swr1 ATPase, Swc2, Swc3, Arp6, Swc5, Yaf9, and Swc6) in maintaining complex integrity and H2AZ histone replacement activity. Here we examined the function of three additional SWR1 subunits, bromodomain containing Bdf1, actin-related protein Arp4 and Swc7, by analyzing affinity-purified mutant SWR1 complexes. We observed that depletion of Arp4 (arp4-td) substantially impaired the association of Bdf1, Yaf9, and Swc4. In contrast, loss of either Bdf1 or Swc7 had minimal effects on overall complex integrity. Furthermore, the basic H2AZ histone replacement activity of SWR1 in vitro required Arp4, but not Bdf1 or Swc7. Thus, three out of fourteen SWR1 subunits, Bdf1, Swc7, and previously noted Swc3, appear to have roles auxiliary to the basic histone replacement activity. The N-terminal region of the Swr1 ATPase subunit is necessary and sufficient to direct association of Bdf1 and Swc7, as well as Arp4, Act1, Yaf9 and Swc4. This same region contains an additional H2AZ-H2B specific binding site, distinct from the previously identified Swc2 subunit. These findings suggest that one SWR1 enzyme might be capable of binding two H2AZ-H2B dimers, and provide further insight on the hierarchy and interdependency of molecular interactions within the SWR1 complex.
Question: Which protein mediates the replacement of H2A by H2A.Z in the yeast Saccharomyces cerevisiae? | [
"swr1"
] | task469-e41ec2dabe274f6594b2d29df4e2cebd | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Caretaker Cabinet of Panagiotis Pikrammenos was sworn in on May 17, 2012 when an inconclusive election on May 6, 2012 resulted in a hung parliament.
Question: What year did Caretaker Cabinet of Panagiotis Pikrammenos end? | [
"2012"
] | task469-d8056d06096540b183924396d932c313 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Stu Shepard (Colin Farrell) is an arrogant New York City publicist who is contemplating cheating on his wife Kelly (Radha Mitchell). He calls Pam (Katie Holmes), a young actress, from a phone booth on a side street. When a delivery man (Dell Yount) tries to deliver a free pizza to the booth, Stu rudely dismisses him. After the phone call with Pam, the phone rings and Stu answers it. The caller (voice of Kiefer Sutherland), says that Stu should have accepted the pizza as it would have "kept his strength up for what comes next". He warns Stu not to leave the booth. Stu, again dismissive, is skeptical toward the mystery caller. The caller says that he will say 'hi' to Kelly for him, then hangs up, leaving Stu visibly concerned.The unseen man calls back and reveals that he had previously setup two other dishonest individuals in a similar situation, where he gave them a chance to redeem themselves but since both refused he had to kill them. One was a pedophile, and the other was a business executive who used inside information to cash in his stock options before the company share price collapsed (and refused the caller's request to share the proceeds with regular investors who got burned on that stock). The caller tells Stu that he must tell Kelly and Pam the truth: that he is cheating. The man calls Pam, puts Stu on speakerphone, and he tells her that Stu is married and does not want anything with Pam except to sleep with her. He then tells Stu to call his wife and tell her the truth, or else he will. Angrily, Stu does so.Before he has a chance to tell Kelly the truth, Stu is distracted by three prostitutes who want to use the phone. The prostitutes become hostile due to Stu's refusal to leave the booth, and they start banging against the glass. Stu becomes agitated and finally hangs up on his wife and yells at the prostitutes to leave him alone. As the three girls leave, the man calls and warns Stu that if he hangs up again, he will shoot him. Stu does not believe him but is convinced when the man cocks his rifle. Stu gets scared, warning him that if he shoots, the cops will arrive. However, the sniper proves him to be wrong by shooting a toy robot next to the booth without anyone noticing. The caller continues to mock Stu's faith that the caller is not capable.The situation escalates further when the prostitutes and their pimp, Leon (John Enos III), approach the booth and demand that Stu leave. Terrified that he will be shot, Stu refuses. The impasse between Stu and Leon escalates to the point of Leon breaking into the booth with a bat and attacking Stu. The sniper tells Stu he can help him and Stu says "yes". Leon is shot in the back by the sniper, horrifying the prostitutes, who accuse Stu.The police arrive and Stu is instantly the suspect. He doubts that they will find any evidence to suggest his guilt to the murder, but later finds out the sniper has planted a gun in the phone booth's roof, on top of the light panel that could be used as evidence in Leon's murder. Captain Ed Ramey (Forest Whitaker) arrives tries to negotiate with Stu to exit the booth but he says he cannot get off the call and he is talking to his "psychiatrist". Multiple news vans arrive, and reporters begin filming the situation, putting pressure on the police to deal with the situation without appearing trigger-happy. The caller continues to taunt Stu by telling him to take hold of the planted gun, or he would "Blow him (Ramey) Away!" but Stu refuses, knowing the police will likely shoot him.Kelly arrives at the scene and the sniper makes Stu confess to her about his infidelity, which Stu does. The man asks Stu to choose between Pam and Kelly, threatening to kill one of them to eliminate further temptation. The unseen caller tells Stu that there are policemen right now trying
Question: Who does the caller demand Stu tell the truth to? | [
"his wife, kelly"
] | task469-979c7a9a9dba4c97b364ff3967f11973 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Duavee, an oral contraceptive; riociguat (Adempas) for two types of pulmonary hypertension; and macitentan (Opsumit) for pulmonary arterial hypertension.
Question: What is generic name of drug Adempas? | [
"riociguat"
] | task469-1ac1eaa90f974cf793975c472b63f8b8 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Restless leg syndrome (RLS) and periodic limb movement disorder (PLMD) are considered to be a continuum of a neurological sleep disorder associated with abnormal iron metabolism or deficiency. I describe a case of RLS and PLMD in a cystic fibrosis patient with iron deficiency from chronic hemoptysis. This is the first case that reports RLS and PLMD manifesting from iron deficiency caused by chronic hemoptysis in advanced cystic fibrosis lung disease.
Question: Which deficiency is the cause of restless leg syndrome? | [
"iron"
] | task469-55a38c0430f74e9d801992dd5bc1a066 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Lake Forest High School Clubs Environmental Club Club members are provided opportunities to realize their goals of environmental service. The majority of projects are student-initiated. Last year's activities included: the LFHS Courtyard Garden upkeep, Bike to School Day with free cocoa and snacks, an "eat local" 100-mile dinner, recycling solutions for LFHS, beach cleanup through the Great Lakes Alliance, and Earth Week celebrations. Meetings: First Friday of the month in Room 5 at 7:00 a.m. Advisor: Ms Mary Beth Nawor, _ Peer Tutoring Students volunteer to help fellow students in improving their academic and organizational skills. Students tutor LFHS and middle school students on an individually scheduled basis. LFHS tutors must have proficiency in the academic area in which they wish to tutor, but middle school tutors only need general academic proficiency. Meetings: All tutoring is done on an individually scheduled basis. Advisor: Ms Kathy O'Hara, _ Young Idea Young Idea is LFHS's art and literary magazine. Students of all ages who love writing and art are encouraged to become part of the staff of this award-winning magazine. Young Idea encourages all students to submit art and literature works to the magazine, whether they are a part of the staff or not. From September to February, Young Idea meets on Thursdays after school in the Public Room to discuss the pieces that have been submitted to the magazine and provide feedback for the authors. Meetings: See above explanation. Advisor: Ms Debbie Zare, _ Scout Buddies Scout Buddies is a friendship club which helps build friendship among individuals with and without disabilities. Club members participate in a variety of social activities both within the school and in the community. Activities include organizing holiday parties in the school, bowling, going to the movies, and eating out in local restaurants. Meetings: Monthly meeting dates vary, but in Room 134. Advisor: Ms Donna Lovitsch, _
Question: Which club provides help for students poor in study? | [
"peer tutoring."
] | task469-3bec9f8de6234a0d80a6adfdfe542e27 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The film opens as Alice Melbourne and Judson Ellis arrive at a California Municipal Airport by taxi. Alighting from the cab they tip the driver generously, bribing him to not say anything to anyone about them. Alice and Judson check the departure sign for The Silver Queen, heading for Panama City, Panama, and seem excited and anxious.Also waiting for the same flight is Peggy Nolan, to whom a delivery of expensive flowers is made with a card thanking her for some favor. Peggy disdainfully tosses the card in the trash and gives the flowers to a woman selling cheap gardenias.Soon after, the flight gets ready to leave and we are introduced to Professor and Mrs. Spengler, an elderly couple, and Joe, the flight's co-pilot, who is immediately attracted to Alice. Mrs. Spengler is a domineering woman, but her husband seems content to be bossed around like a child.As they wait on the tarmac near the 'plane a car drives up and a well dressed man emerges with a young boy and another man. The boy is Tommy and he is being sent away with "Uncle" Pete until his father -- a mobster -- can follow later.As the passengers board, Bill, the pilot, receives word that they will be transporting an anarchist back to Panama, but he assures the group there is nothing to worry about since the man will be in custody during the flight. The prisoner is Vasquez, and is being accompanied by a bounty hunter named Crimp.After Larry the steward helps everyone get settled, the flight departs with its twelve souls aboard. Bill and Joe discuss plans for the layover and Joe indicates he has an interest in Alice. He goes back to the passenger compartment where beds have been made up and people are turning in for the night -- except for Crimp who plans to stay up and make sure Vasquez doesn't "go for a walk" -- thus cheating the hangman and himself out of $5,000.Pete tucks his young charge in for the night and helps him say his prayers (something Pete is unfamiliar with). Peggy comes up to the cockpit to visit with Bill, whose rudeness finally makes it clear that he wants nothing to do with her. When Alice rings for the steward, Joe takes the call and makes a play for her.Next morning the 'plane arrives for a refueling stop in Mexico and the passengers have breakfast. Joe continues to pursue Alice, under the assumption that she is Judson's secretary. Peggy makes another stab at getting Bill to warm to her and is rebuffed again. Then Pete tells her that her help isn't needed when she tries to get Tommy to drink his milk. Peggy's been "marked" as a loose woman by her fellow travelers who want nothing to do with her.Before boarding the 'plane a reporter confronts Judson and Alice and Joe learns that she is engaged to her "boss" and they are eloping.As the flight continues and heads into stormy weather the Professor discusses the methods by which a South American tribe of headhunters practice their craft. The conversation is interrupted by a news bulletin which recounts how Tommy's father has been killed. Peggy again tries to help with Tommy, saying "he needs a woman." But Pete is still being judgemental and answers "he needs a lady." Mrs. Spengler intervenes and comforts Tommy.As the storm they are flying through gets rougher, the passengers strap themselves into their seats and Crimp insists the pilots turn back. As the 'plane rocks back and forth a couple of metal cylinders break loose and crash through the back door. Tommy comes perilously close to going out the door when Llarry saves him and hands him to Pete. Just then the 'plane dips sharply and Larry is tossed out the door to his death. As Joe and Bill try to steady the 'plane Crimp tries to force them to turn back by waving his gun at them. In the struggle the gun goes off and is picked up by Vasquez.With a damaged engine the Silver Queen crashes, and all eleven on board survive. The next morning Joe and Bill admit to the professor that they were blown off
Question: Who patches the airliner's oil leak? | [
"bill and joe"
] | task469-476ee4ab9cc044a7b05c20e0200d5f9c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Scientists have been aware for many years of genetic programs that get activated under stress and produce genetic variants in cells that escape non-proliferating conditions. These programs are well conserved in all organisms and expand our view of evolution. They mediate genome instability, create diversity in antibody formation, expand metabolism and increase fitness of pathogens within host environments. Error-prone DNA replication and repair are genetic variability-causing agents that get stimulated by the onset of cellular stresses. Embedded in these programs is the ability to limit mutagenesis to defined genomic regions and times, ensuring integrity of most of the genome. Recent evidence suggests that factors involved in RNA polymerase (RNAP) processivity or transcriptional derepression contribute to the generation of stress-induced mutations. In Bacillus subtilis, transcription-associated mutagenesis has been shown to be independent of recombination-dependent repair and, in some cases, of the Y DNA polymerases. Central to stationary-phase mutagenesis in B. subtilis is the requirement for Mfd, transcription coupling repair factor, which suggests a novel mechanism from those described in other model systems.
Question: In which phase of cell cycle does stress-induced transcription-associated mutagenesis (TAM) occur? | [
"stationary-phase",
"stationary phase"
] | task469-8d9305f507be4fefaacf3e8699006b7d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The officials of a city unveil a new statue, only to find The Tramp sleeping on it. They shoo him away and he wanders the streets, destitute and homeless, and is soon tormented by two newsboys. He happens upon a beautiful Flower Girl (Virginia Cherrill), not realizing at first that she is blind, and buys a flower. Just when she is about to give him his change, a man gets into a nearby luxury car and is driven away, making her think that the Tramp has departed. The Tramp tiptoes away. That evening, the Tramp runs into a drunken Millionaire (Harry Myers) who is attempting suicide on the waterfront. (It is later mentioned that his wife has sent for her bags.) The Tramp eventually convinces The Millionaire he should live. He takes the Tramp back to his mansion and gives him a change of clothes. They go out for a night on the town, where the Tramp inadvertently causes much havoc. Early the next morning, they return to the mansion and encounter the Flower Girl en route to her vending spot. The Tramp asks The Millionaire for some money, which he uses to buy all the girl's flowers and then drives her home in the Millionaire's Rolls-Royce.After he leaves, the Flower Girl tells her Grandmother (Florence Lee) about her wealthy acquaintance. When the Tramp returns to the mansion, the Millionaire has sobered and does not remember him, so has the butler order him out. Later that day, the Millionaire meets the Tramp again while intoxicated, and invites him home for a lavish party. The next morning, having sobered again and planning to leave for a cruise, the Millionaire again has the Tramp tossed out.Returning to the Flower Girl's apartment, the Tramp spies her being attended by a doctor. Deciding to take a job to earn money for her, he becomes a street sweeper. Meanwhile, the Grandmother receives a notice that she and the girl will be evicted if they cannot pay their back rent by the next day, but hides it. The Tramp visits the girl on his lunch break, and sees a newspaper story about a Viennese doctor who has devised an operation that cures blindness. He then finds the eviction notice and reads it aloud at the girl's request. He reassures her that he will pay the rent. But he returns to work late and is fired.As he is walking away, a boxer persuades him to stage a fake fight, promising to split the $50 prize money. Just before the bout, however, the man receives a telegram warning him that the police are after him. He flees, leaving the Tramp a no-nonsense replacement opponent. Despite a valiant effort, the Tramp is knocked out.Some time later, he meets the drunken Millionaire who has just returned from Europe. The Millionaire takes him to the mansion and after he hears the girl's plight, gives the Tramp $1,000. Unbeknownst to the Millionaire and the Tramp, two burglars were hiding in the house when they entered. Upon hearing about the cash, they knock out the millionaire and take the rest of his money. The Tramp telephones for the police, but the robbers flee before they arrive, and the butler assumes he stole the money. The Millionaire cannot remember the Tramp or giving him the $1,000. The Tramp narrowly escapes and gives the money to the girl saying he will be going away for a while. Later, he is arrested in front of the newsboys who taunted him earlier, and jailed.Months later, the Tramp is released. Searching for the girl, he returns to her customary street corner but does not find her. With her sight restored, the girl has opened up a flourishing flower shop with her Grandmother. When a rich customer comes into the shop, the girl briefly wonders if he is her mysterious benefactor. But when he leaves with no acknowledgement, she realizes again she is wrong. While retrieving a flower from the gutter outside the shop, the Tramp is again tormented by the two newsboys. As he turns to leave, he finds himself staring at the girl
Question: How many burglars were hiding in the house? | [
"two"
] | task469-183a169859a54e85849f78727286a79c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: There are many things you can do to protect yourself before, during, and after an earthquake. Have an engineer evaluate the house for structural integrity. Make sure the separate pieces floor, walls, roof, and foundation are all well-attached to each other. Bracket or brace brick chimneys to the roof. Be sure that heavy objects are not stored in high places. Secure water heaters all around and at the top and bottom. Bolt heavy furniture onto walls with bolts, screws, or strap hinges. Replace halogen and incandescent light bulbs with fluorescent bulbs to lessen fire risk. Check to see that gas lines are made of flexible material so that they do not rupture. Any equipment that uses gas should be well secured. Everyone in the household should know how to shut off the gas line. Prepare an earthquake kit with three days supply of water and food, a radio, and batteries. Place flashlights all over the house and in the glove box of your car. Keep several fire extinguishers around the house to fight small fires. Be sure to have a first aid kit. Everyone should know basic first aid and CPR. Plan in advance how you will evacuate and where you will go. Do not plan on driving, as roadways will likely be damaged. If you are in a building, get beneath a sturdy table, cover your head, and hold on. Stay away from windows, mirrors, and large furniture. If the building is structurally unsound, get outside as fast as possible. If you are outside, run to an open area away from buildings and power lines that may fall. If you are in a car, stay in the car and stay away from structures that might collapse, such as overpasses, bridges, or buildings. Be aware that aftershocks are likely. Avoid dangerous areas like hillsides that may experience a landslide. Turn off water and power to your home. Use your phone only if there is an emergency. Many people will be trying to get through to emergency services. Be prepared to wait for help or instructions. Assist others as necessary. Click image to the left or use the URL below. URL:
Question: which of these needs to be done after an earthquake? | [
"turn off water and power to your home."
] | task469-6a41d70168924654a12e0f9f55266ca3 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Vanoxerine has been in clinical trials for Parkinsonism, depression and cocaine addiction but lacked efficacy. Although a potent blocker of hERG, it produced no serious adverse events. We attributed the unexpected result to offsetting Multiple Ion Channel Effects (MICE). Vanoxerine's effects were strongly frequency-dependent and we repositioned it for treatment of atrial fibrillation and flutter. Vanoxerine terminated AF/AFL in an animal model and a dose-ranging clinical trial. Reversion to normal rhythm was associated with QT prolongation yet absent proarrhythmia markers for Torsade de Pointes (TdP). To understand the QT/TdP discordance, we used quantitative profiling and compared vanoxerine with dofetilide, a selective hERG-blocking torsadogen used for intractable AF, verapamil, a non-torsadogenic MICE comparator and bepridil, a torsadogenic MICE comparator. At clinically relevant concentrations, verapamil blocked hCav1.2 and hERG, as did vanoxerine and bepridil both of which also blocked hNav1.5. In acute experiments and simulations, dofetilide produced early after depolarizations (EADs) and arrhythmias, whereas verapamil, vanoxerine and bepridil produced no proarrhythmia markers. Of the MICE drugs only bepridil inhibited hERG trafficking following overnight exposure. The results are consistent with the emphasis on MICE of the CiPA assay. Additionally we propose that trafficking inhibition of hERG be added to CiPA.
Question: What alternate indication has Vanoxerine been repositioned for? | [
"atrial fibrillation and flutter"
] | task469-46dcb2fc8ce84f54850c50e4a6175376 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Problems can occur with red blood cells, white blood cells, platelets, and other parts of the blood. Many blood disorders are genetic, meaning they are inherited from a parent. Some blood diseases are caused by not getting enough of a certain nutrient, while others are cancers of the blood. Anemia is a disease that occurs when there is not enough hemoglobin in the blood to carry oxygen to body cells. Hemoglobin is the blood protein that normally carries oxygen from the lungs to the tissues. Anemia leads to a lack of oxygen in organs. Anemia is usually caused by one of the following: A loss of blood from a bleeding wound or a slow leak of blood. The destruction of red blood cells. A lack of red blood cell production. Anemia may not have any symptoms. Some people with anemia feel weak or tired in general or during exercise. They also may have poor concentration. People with more severe anemia often get short of breath during times of activity. Iron-deficiency anemia is the most common type of anemia. It occurs when the body does not receive enough iron. Since there is not enough iron, hemoglobin, which needs iron to bind oxygen, cannot function properly. In the United States, 20% of all women of childbearing age have iron-deficiency anemia, compared with only 2% of adult men. The most common cause of iron-deficiency anemia in young women is blood lost during menstruation. Iron deficiency anemia can be avoided by getting the recommended amount of iron in ones diet. Anemia is often treated or prevented by taking iron supplements. Boys and girls between the ages of 9 and 13 should get 9 mg of iron every day. Girls between the ages of 14 and 18 should get 15 mg of iron every day. Boys between the ages of 14 and 18 should get 11 mg of iron every day. Pregnant women need the most iron27 mg daily. Good sources of iron include shellfish, such as clams and oysters. Red meats, such as beef, are also a good source of iron. Non-animal sources of iron include seeds, nuts, and legumes. Breakfast cereals often have iron added to them in a process called fortification. Some good sources of iron are listed below ( Table 1.1). Eating vitamin C along with iron-containing food increases the amount of iron that the body can absorb. Food Canned clams, drained, 3 oz. Fortified dry cereals, about 1 oz. Roasted pumpkin and squash seeds, 1 oz. Cooked lentils, 12 cup Cooked fresh spinach, 21 cup Cooked ground beef, 3 oz. Cooked sirloin beef, 3 oz. Milligrams (mg) of Iron 23.8 1.8 to 21.1 4.2 3.3 3.2 2.2 2.0 Sickle-cell anemia is a blood disease that is caused by an abnormally shaped hemoglobin protein in red blood cells. Many of the red blood cells of a person with sickle-cell anemia are long and curved (sickle-shaped) ( Figure 1.1). The long, sickle shape of the cells can cause them to get stuck in narrow blood vessels. This clotting means that oxygen cannot reach the cells. People with sickle-cell anemia are most often well but can occasionally have painful attacks. The disease is not curable, but it can be treated with medicines. The red blood cells of a person with sickle-cell anemia (left) are long and pointed, rather than straight, like normal cells (right). The abnormal cells cannot carry oxygen properly and can get stuck in capillaries. Blood cancers affect the production and function of your blood cells. Most of these cancers start in your bone marrow where blood is produced. In most blood cancers, the normal production of blood cells is replaced by uncontrolled growth of an abnormal type of blood cell. These abnormal blood cells are cancerous cells, and prevent your blood from performing many of its functions, like fighting off infections or preventing serious bleeding. Leukemia is a cancer of the blood or bone marrow. It is characterized by an abnormal production of blood cells, usually white blood cells. Lymphoma is a cancer of a type of white blood cell called
Question: which food is the best source of iron? | [
"shellfish"
] | task469-3830e81bd7c746a9ae6901fb491e9d39 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Pollution that enters water at just one point is called point source pollution. For example, chemicals from a factory might empty into a stream through a pipe or set of pipes (see Figure 21.9). Pollution that enters in many places is called non-point source pollution. This means that the pollution is from multiple sources. With non-point source pollution, runoff may carry the pollution into a body of water. Which type of pollution do you think is harder to control? There are three main sources of water pollution: 1. Agriculture. 2. Industry. 3. Municipal, or community, sources. Huge amounts of chemicals, such as fertilizers and pesticides, are applied to farm fields (see Figure 21.10). Some of the chemicals are picked up by rainwater. Runoff then carries the chemicals to nearby rivers or lakes. Dissolved fertilizer causes too much growth of water plants and algae. This can lead to dead zones where nothing can live in lakes and at the mouths of rivers. Some of the chemicals can infiltrate into groundwater. The contaminated water comes up in water wells. If people drink the polluted water, they may get sick. Waste from livestock can also pollute water. The waste contains bacteria and other organisms that cause disease. In fact, more than 40 human diseases can be caused by water polluted with animal waste. Many farms in the U.S. have thousands of animals. These farms produce millions of gallons of waste. The waste is stored in huge lagoons, like the one in Figure 21.11. Unfortunately, many leaks from these lagoons have occurred. Two examples are described below. In North Carolina, 25 million gallons of hog manure spilled into a nearby river. The contaminated water killed Factories and power plants may pollute water with harmful substances. Many industries produce toxic chemicals. Some of the worst are arsenic, lead, and mercury. Nuclear power plants produce radioactive chemicals. They cause cancer and other serious health problems. Oil tanks and pipelines can leak. Leaks may not be noticed until a lot of oil has soaked into the ground. The oil may pollute groundwater so it is no longer fit to drink. Municipal refers to the community. Households and businesses in a community are also responsible for polluting the water supply. For example: People apply chemicals to their lawns. The chemicals may be picked up by rainwater. The contaminated runoff enters storm sewers and ends up in nearby rivers or lakes. Underground septic tanks can develop leaks. This lets household sewage seep into groundwater. Municipal sewage treatment plants dump treated wastewater into rivers or lakes. Sometimes the wastewater is not treated enough and contains bacteria or toxic chemicals. The oceans are vast. You might think they are too big to be harmed by pollution. But thats not the case. Ocean water is becoming seriously polluted. The oceans are most polluted along coasts. Why do you think thats the case? Of course, its because most pollution enters the oceans from the land. Runoff and rivers carry the majority of pollution into the ocean. Many cities dump their wastewater directly into coastal waters. In some parts of the world, raw sewage and trash may be thrown into the water (see Figure 21.12). Coastal water may become so polluted that people get sick if they swim in it or eat seafood from it. The polluted water may also kill fish and other ocean life. Oil spills are another source of ocean pollution. To get at oil buried beneath the seafloor, oil rigs are built in the oceans. These rigs pump oil from beneath the ocean floor. Huge ocean tankers carry oil around the world. If something goes wrong with a rig on a tanker, millions of barrels of oil may end up in the water. The oil may coat and kill ocean animals. Some of the oil will wash ashore. This oil may destroy coastal wetlands and ruin beaches. Figure 21.13 shows an oil spill on a beach. The oil washed ashore after a deadly oil rig explosion in the Gulf of Mexico in 2010. Thermal pollution is pollution that raises the temperature of water. This is caused by power plants and factories that
Question: major cause of water pollution | [
"agriculture"
] | task469-fb69f05f2e4f48b9a8cc80e5eac141b8 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: After an inquest held in a nearby hotel, Florence Maybrick was charged with his murder and stood trial at St George's Hall, Liverpool, before Justice James Fitzjames Stephen, where she was convicted and sentenced to death.
Question: Which crime Florence Maybrick is considered to have commited? | [
"murder"
] | task469-5bbfec9b365d40168ee0f60f467a292c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The U.S. Census for 2010 reported 332,199 households in Indianapolis, with an average household size of 2.42 and an average family size of 3.08. Of the total households, 59.3% were family households, with 28.2% of these including the familys own children under the age of 18; 36.5% were husband-wife families; 17.2% had a female householder (with no husband present) and 5.6% had a male householder (with no wife present). The remaining 40.7% were non-family households. , 32% of the non-family households included individuals living alone, 8.3% of these households included individuals age 65 years of age or older.
Question: Which group from the census is smaller: family households or husband-wife families? | [
"husband-wife families"
] | task469-4b02ca788a494b4c8ee43d2042369140 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
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