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Context: zfhz1b is the causative gene for Mowat-Wilson syndrome, in which patients demonstrate developmental delay and Hirschsprung disease, as well as other anomalies. We identified a patient with Mowat-Wilson syndrome who also developed cholestasis and histopathologic features consistent with biliary atresia, suggesting that mutations involving zfhz1b may lead to biliary developmental anomalies or injury to the biliary tract. We used the zebrafish model system to determine whether zfhx1b has a role in vertebrate biliary development. Using zebrafish we determined that zfhx1b was expressed in the developing liver during biliary growth and remodeling, and that morpholino antisense oligonucleotide-mediated knockdown of zfhx1b led to defects in biliary development. These findings were associated with decreased expression of vhnf1, a transcription factor known to be important in biliary development in zebrafish and in mammals. Our studies underscore the importance of genetic contributions in the etiology of infantile hepatobiliary disorders, including biliary atresia.
Question: Which gene is responsible for the development of the Mowat-Wilson syndrome?
|
[
"zeb2",
"zfhx1b",
"sip-1"
] |
task469-9261a0997a744c749c5192431f13c8dc
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The mouth and stomach are just two of the organs of the digestive system. Other digestive system organs are the esophagus, small intestine, and large intestine. Below, you can see that the digestive organs form a long tube ( Figure 1.1). In adults, this tube is about 30 feet long! At one end of the tube is the mouth. At the other end is the anus. Food enters the mouth and then passes through the rest of the digestive system. Food waste leaves the body through the anus. The organs of the digestive system are lined with muscles. The muscles contract, or tighten, to push food through the system ( Figure 1.2). The muscles contract in waves. The waves pass through the digestive system like waves through a slinky. This movement of muscle contractions is called peristalsis. Without peristalsis, food would not be able to move through the digestive system. Peristalsis is an involuntary process, which means that it occurs without your conscious control. The liver, gallbladder, and pancreas are also organs of the digestive system ( Figure 1.1). Food does not pass through these three organs. However, these organs are important for digestion. They secrete or store enzymes or other chemicals that are needed to help digest food chemically. The mouth is the first organ that food enters. But digestion may start even before you put the first bite of food into your mouth. Just seeing or smelling food can cause the release of saliva and digestive enzymes in your mouth. This diagram shows how muscles push food through the digestive system. Muscle contractions travel through the system in waves, pushing the food ahead of them. This is called peristalsis. Once you start eating, saliva wets the food, which makes it easier to break up and swallow. Digestive enzymes, including the enzyme amylase, start breaking down starches into sugars. Your tongue helps mix the food with the saliva and enzymes. Your teeth also help digest food. Your front teeth are sharp. They cut and tear food when you bite into it. Your back teeth are broad and flat. They grind food into smaller pieces when you chew. Chewing is part of mechanical digestion. Your tongue pushes the food to the back of your mouth so you can swallow it. When you swallow, the lump of chewed food passes down your throat to your esophagus. The esophagus is a narrow tube that carries food from the throat to the stomach. Food moves through the esophagus because of peristalsis. At the lower end of the esophagus, a circular muscle controls the opening to the stomach. The muscle relaxes to let food pass into the stomach. Then the muscle contracts again to prevent food from passing back into the esophagus. Some people think that gravity moves food through the esophagus. If that were true, food would move through the esophagus only when you are sitting or standing upright. In fact, because of peristalsis, food can move through the esophagus no matter what position you are ineven upside down! Just dont try to swallow food when you are upside downyou could choke! The stomach is a sac-like organ at the end of the esophagus. It has thick muscular walls. The muscles contract and relax. This moves the food around and helps break it into smaller pieces. Mixing the food around with the enzyme pepsin and other chemicals helps digest proteins. Water, salt, and simple sugars can be absorbed into the blood from the stomach. Most other substances are broken down further in the small intestine before they are absorbed. The stomach stores food until the small intestine is ready to receive it. A circular muscle controls the opening between the stomach and small intestine. When the small intestine is empty, the muscle relaxes. This lets food pass from the stomach into the small intestine. The small intestine a is narrow tube that starts at the stomach and ends at the large intestine ( Figure 1.1). In adults, the small intestine is about 23 feet long. Chemical digestion takes place in the first part of the small intestine. Many enzymes and other chemicals are secreted here. The small intestine is also where most nutrients are absorbed into the blood.
Question: what is the first step in the digestive process?
|
[
"the release of saliva and digestive enzymes in your mouth"
] |
task469-10e6acc0d4314907a7dbac647f2b4f92
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: In The Future, a beautiful astronomatrix named Barbarella (Jane Fonda) floats through the galaxy in her spaceship, the Alpha-7. Suddenly she receives an urgent call on her monitor from none other than the President of Earth (Claude Dauphin). He informs her that a young scientist named Durand-Durand went missing sometime during a mission to the North Star and is believed to have landed somewhere in the Tau Ceti star system. Not much is known about this region of space-- the President worries that Durand's invention, the positronic ray, may fall into the hands of a primitive culture; beings who might seek to use this technology as a weapon and launch an intergalactic war. Since the Earth, free of all conflict for centuries, lacks military and police personnel, the President tasks Barbarella with a mission to find the scientist. He teleports her some weapons and a device that will signal the presence of Durand-Durand. The latter has a "tonguebox" incorporated in its design which can translate any language.Barbarella spends most of the journey to Tau Ceti in suspended animation. She awakens just in time to lose control of her spacecraft and crash land on Planet 16, which her spaceship informs her contains an atmosphere similar to Earth's. She changes into a new outfit to explore the arctic terrain. The first humanoids she meets are a pair of twin girls-- they jabber to her excitedly in a language she can't understand. Before she can adjust her tonguebox, one of them knocks Barbarella unconscious with a piece of ice. The girls then pull the dazed explorer along in their sled, which is attached to a manta ray-like creature that glides across the ice.The girls arrive with Barbarella at the wreck of another craft where several other sets of twin children are sheltered and indigo-blue bunny rabbits abound. Barbarella recognizes the wreck as the Alpha-1, former spaceship of Durand-Durand. The children tie Barbarella to a post and bring out several mechanical dolls that walk towards her. It soon becomes apparent that the dolls all have sharp metal teeth and hinged jaws. They bite Barbarella while the children giggle gleefully, amused by their game.Suddenly a man appears with several armored guards. He cracks a whip and captures the children in a net, then unties Barbarella. Once she gets her tonguebox working, she's able to understand him when he explains that he is a Catchman named Mark Hand (Ugo Tognazzi) and that all children are sent away to the forests of Weir "until they've reached a serviceable age," at which point he captures them and brings them back to civilization. He offers Barbarella a ride back to her spaceship. When she asks how she can repay him, he tells her that he'd like to make love to her. Back on Earth, when people want to bond, erotically, they each take an exultation transference pill and press their palms against one another's. Barbarella is prepared to do this with the Catchman, but he's not interested in all that, he tells Barbarella that he wants to have sex on the bed in his snowship. She reluctantly agrees to do it the old-fashioned way, but soon discovers that she finds the experience quite enjoyable. The Catchman gives her a fur and repairs her spaceship, only when she tries to fly off, the ship's computer informs her that it's been repaired in reverse. She crashes back into the planet and quickly activates the ship's terra-screws so that she can tunnel through the planet's core.She surfaces in the Labyrinth, amongst strange creatures including an "ornithanthrope," or angel, named Pygar (John Phillip Law), who was blinded in the city of Sogo. Pygar takes Barbarella to visit Professor Ping (Marcel Marceau) who explains that Pygar is aerodynamically sound, but lacks the morale to fly. Pygar, Professor Ping and all of the other unfortunates who roam the Labyrinth were imprisoned there by order of the Great Tyrant. They are not evil enough to be allowed to live in Sogo, the City of Night. Pygar takes Barbarella to his nest where they have sex. This restores Pygar's will to fly and Barbarella
Question: Who offered to repair the ship?
|
[
"the catchman",
"professor ping"
] |
task469-647d0ed2d07345b5a3ea6c134e5fd29b
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The major cause of outdoor air pollution is the burning of fossil fuels. Fossil fuels are burned in power plants, factories, motor vehicles, and home heating systems. Ranching and using chemicals such as fertilizers also cause outdoor air pollution. Erosion of soil in farm fields, mining activities, and construction sites adds dust particles to the air as well. Some specific outdoor air pollutants are described in Table 25.1. Air Pollutant Sulfur oxides Nitrogen oxides Carbon monoxide Carbon dioxide Particles (dust, smoke) Mercury Smog Ground-level ozone Source coal burning motor vehicle exhaust motor vehicle exhaust all fossil fuel burning wood and coal burning coal burning coal burning motor vehicle exhaust Problem acid rain acid rain poisoning global climate change respiratory problems nerve poisoning respiratory problems respiratory problems Outdoor air pollution causes serious human health problems. For example, pollutants in the air are major contributors to respiratory and cardiovascular diseases. Air pollution may trigger asthma attacks and heart attacks in people with underlying health problems. In fact, more people die each year from air pollution than automobile accidents. Air pollution may also cause acid rain. This is rain that is more acidic (has a lower pH) than normal rain. Acids form in the atmosphere when nitrogen and sulfur oxides mix with water in air. Nitrogen and sulfur oxides come mainly from motor vehicle exhaust and coal burning. If acid rain falls into lakes, it lowers the pH of the water and may kill aquatic organisms. If it falls on the ground, it may damage soil and soil organisms. If it falls on plants, it may make them sick or even kill them. Acid rain also damages stone buildings, bridges, and statues, like the one in Figure 25.1. Another major problem caused by air pollution is global climate change. Gases such as carbon dioxide from the burning of fossil fuels increase the greenhouse effect and raise Earths temperature. The greenhouse effect is a natural feature of Earths atmosphere. It occurs when certain gases in the atmosphere, including carbon dioxide, radiate the suns heat back down to Earths surface. Figure 25.2 shows how this happens. Without greenhouse gases in the atmosphere, the heat would escape into space. The natural greenhouse effect of Earths atmosphere keeps the planets temperature within a range that can support life. The rise in greenhouse gases due to human actions is too much of a good thing. It increases the greenhouse effect and causes Earths average temperature to rise. Rising global temperatures, in turn, are melting polar ice caps and glaciers. Figure 25.3 shows how much smaller the Arctic ice cap was in 2012 than it was in 1984. With more liquid water on Earths surface, sea levels are rising. Adding more heat energy to Earths atmosphere also causes more extreme weather and changes in precipitation patterns. Global warming is already causing food and water shortages and species extinctions. These problems will only grow worse unless steps are taken to curb greenhouse gases and global climate change. You may be able to avoid some of the health effects of outdoor air pollution by staying indoors on high-pollution days. However, some indoor air is just as polluted as outdoor air. One source of indoor air pollution is radon gas. Radon is a radioactive gas that may seep into buildings from rocks underground. Exposure to radon gas may cause lung cancer. Another potential poison in indoor air is carbon monoxide. It may be released by faulty or poorly vented furnaces or other fuel-burning appliances. Indoor furniture, carpets, and paints may release toxic compounds into the air as well. Other possible sources of indoor air pollution include dust, mold, and pet dander. Its easier to control the quality of indoor air than outdoor air. Steps home owners can take to improve indoor air quality include: keeping the home clean so it is as free as possible from dust, mold, and pet dander. choosing indoor furniture, flooring, and paints that are low in toxic compounds such as VOCs (volatile organic compounds). making sure that fuel-burning appliances are working correctly and venting properly. installing carbon monoxide alarms like the one in Figure 25.4 at every level of the home.
Question: __main gas that is causing global climate change
|
[
"carbon dioxide"
] |
task469-8389880e5ec94662ab7d7bb13a142ae7
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Hyposmocoma menehune is a species of moth of the Cosmopterigidae family.
Question: Is Hyposmocoma menehune a genus or species?
|
[
"species"
] |
task469-043adfcf77aa4eb6ac56ae48f9863c86
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Biotic and abiotic factors determine the population size of a species in an ecosystem. What are some important biotic factors? Biotic factors include the amount of food that is available to that species and the number of organisms that also use that food source. What are some important abiotic factors? Space, water, and climate all help determine a species population. When does a population grow? A population grows when the number of births is greater than the number of deaths. When does a population shrink? When deaths exceed births. What causes a population to grow? For a population to grow there must be ample resources and no major problems. What causes a population to shrink? A population can shrink either because of biotic or abiotic limits. An increase in predators, the emergence of a new disease, or the loss of habitat are just three possible problems that will decrease a population. A population may also shrink if it grows too large for the resources required to support it. When the number of births equals the number of deaths, the population is at its carrying capacity for that habitat. In a population at its carrying capacity, there are as many organisms of that species as the habitat can support. The carrying capacity depends on biotic and abiotic factors. If these factors improve, the carrying capacity increases. If the factors become less plentiful, the carrying capacity drops. If resources are being used faster than they are being replenished, then the species has exceeded its carrying capacity. If this occurs, the population will then decrease in size. Every stable population has one or more factors that limit its growth. A limiting factor determines the carrying capacity for a species. A limiting factor can be any biotic or abiotic factor: nutrient, space, and water availability are examples (Figure 1.1). The size of a population is tied to its limiting factor. What happens if a limiting factor increases a lot? Is it still a limiting factor? If a limiting factor increases a lot, another factor will most likely become the new limiting factor. This may be a bit confusing, so lets look at an example of limiting factors. Say you want to make as many chocolate chip cookies as you can with the ingredients you have on hand. It turns out that you have plenty of flour and other ingredients, but only two eggs. You can make only one batch of cookies, because eggs are the limiting factor. But then your neighbor comes over with a dozen eggs. Now you have enough eggs for seven batches of cookies, but only two pounds of butter. You can make four batches of cookies, with butter as the limiting factor. If you get more butter, some other ingredient will be limiting. Species ordinarily produce more offspring than their habitat can support (Figure 1.2). If conditions improve, more young survive and the population grows. If conditions worsen, or if too many young are born, there is competition between individuals. As in any competition, there are some winners and some losers. Those individuals that survive to fill the available spots in the niche are those that are the most fit for their habitat. Click image to the left or use the URL below. URL: A frog in frog spawn. An animal produces many more offspring than will survive.
Question: if a pack of coyotes enters a region, the carrying capacity for bunnies will likely
|
[
"decrease."
] |
task469-9e6464a41ac642d382368424c604711e
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Protective protein/cathepsin A (PPCA) has a serine carboxypeptidase activity of unknown physiological function. We now demonstrate that this protease activity triggers the degradation of the lysosome-associated membrane protein type 2a (lamp2a), a receptor for chaperone-mediated autophagy (CMA). Degradation of lamp2a is important because its level in the lysosomal membrane is a rate-limiting step of CMA. Cells defective in PPCA show reduced rates of lamp2a degradation, higher levels of lamp2a and higher rates of CMA. Restoration of PPCA protease activity increases rates of lamp2a degradation, reduces levels of lysosomal lamp2a and reduces rates of CMA. PPCA associates with lamp2a on the lysosomal membrane and cleaves lamp2a near the boundary between the luminal and transmembrane domains. In addition to the well-studied role of PPCA in targeting and protecting two lysosomal glycosidases, we have defined a role for the proteolytic activity of this multifunctional protein.
Question: Which is the receptor for substrates of Chaperone Mediated Autophagy?
|
[
"lamp2a",
"lysosome-associated membrane protein 2 isoform a"
] |
task469-f0ead170de7542958c4ba53f53d3c10c
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The film opens on October 30, 1988, nearly ten years after Michael Myers's last murderous rampage in Haddonfield, Illinois. An ambulance from Smith's Grove, IL makes its way along the road in a thunderstorm toward the Ridgemont Federal Sanitarium, where Michael, who has been in a coma since then, has been incarcerated. After the apprehensive transfer crew is seen off by medical chief of staff Dr. Hoffman, the ambulance makes its way up the driveway in the storm and back out onto the highway toward Smith's Grove. While in the ambulance, he hears that eight-year-old Jamie Lloyd, his niece and the daughter of Laurie Strode, his first target, is residing in Haddonfield. He immediately grabs and repeatedly bashes a hospital attendant's head against the wall of the ambulance and stabs his finger right into his skull. The other attendant, trapped by the ambulance's locked doors, can only watch helplessly. Soon after, the film introduces Jamie, who has been adopted by the Carruthers family and is still mourning the loss of her mother. Laurie supposedly died in a car accident eleven months earlier. Her older foster sister Rachel comes into her room and consoles her, telling her that she will love her just as much as her mother did. Rachel sends Jamie off to bed and exits the room. Jamie kneels down next to the bed and says her prayers when suddenly, lightning and thunder crash outside, startling her. The door creaks open and as Jamie gets up to close it, the reflection of Michael, donned in his classic white mask and black coveralls, appears in the mirror. Jamie returns to her bed and instantly, Michael's hand reaches out from under the bed and grabs her by the leg. Jamie struggles, gets loose, and runs to her closet. Opening the door, a second Michael appears in front of her, raising his knife. Jamie screams again, attracting the attention of her foster mother, Darlene, who rushes into the room. She finds Jamie, shaking on the floor of her closet, traumatized after what was only a horrific nightmare.Dr. Loomis angrily marches into Hoffman's office the next day, berating him about the transfer of Michael Myers. Hoffman explains that it was mandated by federal law; as he does, he is interrupted by a phone call informing him of an accident involving the ambulance that was carrying Michael Myers. Immediately Loomis smells trouble, and the two men drive to the site of the accident. The state police have secured the scene; the ambulance is upside-down in a river with blood on both the outside & interior. One trooper tells Hoffman it was likely an accident, but Loomis does not believe it. Despite Hoffman's admonishments, Loomis wades into the river & walks round to the ambulance's rear. Inside is a scene of horror; blood is sprayed all over the walls & floor of the ambulance. Immediately, Loomis heads toward Haddonfield, certain that Michael Myers is headed there. Meanwhile, at a gas station, a mechanic works beneath a car, calling for someone to hand him a wrench. When he hears no response, he slides out. There is Michael, raising a long, sharp pole in the air. He thrusts it down into the mechanic's stomach, killing him instantly. Loomis soon after arrives at the gas station and finds the mechanic's body, hanging by a chain from the roof. He also finds several other bodies and immediately sees Michael, standing against the back wall. Loomis shoots at him, but Michael disappears. Loomis scurries out to the exterior of the gas station, barely catching Michael driving away in a truck. Just after, the entire gas station explodes. Loomis survives after crouching behind a nearby barrel.Meanwhile, Jamie is coming home from school to see several kids coming upon her, taunting her that she has no mother. Jamie runs from the scene, crying. At home, Rachel plans to go out for Halloween with her boyfriend, Brady, but her parents refuse and force her to take Jamie trick-or-treating. Rachel protests and Jamie overhears, upset at the fact that Rachel
Question: Where do Jamie and Dr. Loomis take shelter while running from Michael?
|
[
"in the school",
"school"
] |
task469-c75882f735144344a0c8f29d40b881ff
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The Steelers' ninth game was an AFC duel with the Patriots. The Steelers trailed early as QB Tom Brady made a 19-yard TD pass to TE Rob Gronkowski. This was followed by kicker Shayne Graham getting a 31-yard field goal. The Steelers responded in the second quarter with kicker Jeff Reed nailing a 22-yard field goal. The Steelers struggled further when Brady threw another TD pass to Gronkowski, this one from 9yards out. That was followed by Brady's scramble 3yards to the endzone for a touchdown (With a failed PAT as the kick went wide-right). The Steelers scored first in the 4th quarter when QB Ben Roethlisberger completed a 6-yard TD pass to WR Emmanuel Sanders. The Steelers looked to create another scoring drive, but it came to a halt when Roethlisberger's pass was intercepted by SS James Sanders and returned 32yards for a touchdown (With a failed 2-point conversion). The Steelers tried to cut the lead with a Roethlisberger 15-yard TD pass to WR Mike Wallace, but the Patriots replied with Brady getting a 25-yard TD pass to Gronkowski. Again the Steelers tried to get closer when Roethlisberger completed a 33-yard TD pass to Wallace, but the Patriots put the game away after Graham hit a 36-yard field goal.
Question: Who scored first
|
[
"patriots"
] |
task469-c27a04a08e794d64baabaf4ac31e9c22
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Wendy Craig (born 20 June 1934) is an English actress who is best known for her appearances in the sitcoms Not in Front of the Children, Butterflies, ...
Question: What is the birth date of Wendy Craig?
|
[
"20 june 1934"
] |
task469-a173d29961634282ac16c2339ee8b2f1
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: My grandmother often said to me, "You can count the number of your true friends on the fingers of one hand." For a long time I thought this was true. However, I've now discovered my grandmother was only half right. Maybe we do only make a few "best" friends in our lifetime, but those aren't the only people that we can call friends. There are many different types. Let me tell you about a few of them. One type of friends is the type I call the "football mom friend". My neighbor Sally is a good example. We both have kids who play football in a football club, and someone has to take them to practice and pick them up. Sally and I and two other mothers take turns to do this. We meet sometimes and have tea and talk about what our kids are doing, but those are the only times that we meet each other. I enjoy being with these women, but we don't do anything else together. Another type is called the "hobby friend". That's the person you share an interest or a hobby with. Michael and Cater, who are brothers, are a good example of this type. We're all in a bird watching club. Every few weekends the members of the club go on a trip to watch different kinds of birds. There's nothing romantic about my relationship with Michael and Cater, of course. We just share interest in birds. Then there's the "other half of the couple" type of friends. Jim is married to Rose, a friend that I've known since college. When Rose married Jim, I realized that I would have to be Jim's friend if I want to continue to be Rose's. Jim and I don't share so many interests, but we do have a friendly relationship.
Question: Many people are mentioned in this passage. Who is the writer's true friend?
|
[
"rose."
] |
task469-5925eb9cd4f943b8ae83a86da0a15973
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Carbon is a very important element to living things. As the second most common element in the human body, we know that human life without carbon would not be possible. Protein, carbohydrates, and fats are all part of the body and all contain carbon. When your body breaks down food to produce energy, you break down protein, carbohydrates, and fat, and you breathe out carbon dioxide. Carbon occurs in many forms on Earth. The element moves through organisms and then returns to the environment. When all this happens in balance, the ecosystem remains in balance too. The short term cycling of carbon begins with carbon dioxide (CO2 ) in the atmosphere. Through photosynthesis, the inorganic carbon in carbon dioxide plus water and energy from sunlight is transformed into organic carbon (food) with oxygen given off as a waste product. The chemical equation for photosynthesis is: Plants and animals engage in the reverse of photosynthesis, which is respiration. In respiration, animals use oxygen to convert the organic carbon in sugar into food energy they can use. Plants also go through respiration and consume some of the sugars they produce. The chemical reaction for respiration is: C6 H12 O6 + 6 O2 6 CO2 + 6 H2 O + useable energy Photosynthesis and respiration are a gas exchange process. In photosynthesis, CO2 is converted to O2 ; in respiration, O2 is converted to CO2 . Remember that plants do not create energy. They change the energy from sunlight into chemical energy that plants and animals can use as food (Figure 1.1). Places in the ecosystem that store carbon are reservoirs. Places that supply and remove carbon are carbon sources and carbon sinks, respectively. If more carbon is provided than stored, the place is a carbon source. If more carbon dioxide is absorbed than is emitted, the reservoir is a carbon sink. What are some examples of carbon sources and sinks? Carbon sinks are reservoirs where carbon is stored. Healthy living forests and the oceans act as carbon sinks. Carbon sources are reservoirs from which carbon can enter the environment. The mantle is a source of carbon from volcanic gases. A reservoir can change from a sink to a source and vice versa. A forest is a sink, but when the forest burns it becomes a source. The amount of time that carbon stays, on average, in a reservoir is the residence time of carbon in that reservoir. Remember that the amount of CO2 in the atmosphere is very low. This means that a small increase or decrease in the atmospheric CO2 can have a large effect. By measuring the composition of air bubbles trapped in glacial ice, scientists can learn the amount of atmospheric CO2 at times in the past. Of particular interest is the time just before the Industrial Revolution, when society began to use fossil fuels. That value is thought to be the natural content of CO2 for this time period; that number was 280 parts per million (ppm). By 1958, when scientists began to directly measure CO2 content from the atmosphere at Mauna Loa volcano in the Pacific Ocean, the amount was 316 ppm (Figure 1.2). In 2014, the atmospheric CO2 content had risen to around 400 ppm. The amount of CO2 in the atmosphere has been measured at Mauna Loa Obser- vatory since 1958. The blue line shows yearly averaged CO2 . The red line shows seasonal variations in CO2 . This is an increase in atmospheric CO2 of 40% since the before the Industrial Revolution. About 65% of that increase has occurred since the first CO2 measurements were made on Mauna Loa Volcano, Hawaii, in 1958. Humans have changed the natural balance of the carbon cycle because we use coal, oil, and natural gas to supply our energy demands. Fossil fuels are a sink for CO2 when they form, but they are a source for CO2 when they are burned. The equation for combustion of propane, which is a simple hydrocarbon looks like this: The equation shows that when propane burns, it uses oxygen and produces carbon dioxide and water. So when a car burns a tank of gas, the amount of CO2 in the atmosphere increases just a little. Added over
Question: in photosynthesis, plants change this into chemical energy that plants and animals can use as food.
|
[
"sunlight"
] |
task469-1f67d4b6a252487982492567086ba131
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Hoping to rebound from a divisional home loss to the Eagles, the Cowboys flew to Bank of America Stadium for a Week 16 Saturday night duel with the Carolina Panthers. In the first quarter, Dallas shot first with QB Tony Romo completing a 10-yard TD pass to WR Terrell Owens for the only score of the period. In the second quarter, the 'Boys continued their assault as RB Marion Barber got a 5-yard TD run. The Panthers would get on the board with QB Matt Moore completing an 11-yard TD pass to WR Steve Smith. The Cowboys end the half with rookie kicker Nick Folk getting a 42-yard field goal. In the third quarter, Carolina started to try a comeback as kicker John Kasay getting a 37-yard field goal for the only score of the period. In the fourth quarter, Dallas would respond with Folk kicking a 23-yard field goal. The Panthers tried to rally as Kasay nailing a 25-yard field goal, yet the 'Boys were able to hold off every possible attempt. With the win, the Cowboys improved to 13-2 and clinched homefield through NFC Playoffs with Green Bay's loss to Chicago on Sunday. Terrell Owens (5 receptions for 48 yards and 1 touchdown) left the game in the second quarter with a high left ankle sprain.
Question: Which player kicked both the longest and shortest field goals?
|
[
"nick folk"
] |
task469-3fc9205e25104722b655032ecf5c114c
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Idarucizumab is a humanized monoclonal antibody fragment for reversal of the anticoagulant effects of dabigatran. This drug can be used for patients who need emergency surgery or invasive procedures, as well as those with life-threatening or uncontrolled bleeding.
Question: Which drug can be reversed with idarucizumab?
|
[
"dabigatran"
] |
task469-85aca2226a83485a8a304b92267914af
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: As the movie opens, we see a guy climbing along the underside of an outcropping from a tall mountain peak. He turns out to be Gabe Walker, a ranger with Rocky Mountain Rescue. (Yes, that makes him "Ranger Walker," and he is addressed as such several times during the course of the movie.) He is in communication with his co-worker and girlfriend, Jessie, who is on a chopper piloted by an older co-worker, Frank. The three are mounting a rescue of yet another co-worker, Hal Tucker, and his girlfriend Sarah, who is on her first climb. Hal and Sarah made it to the top of the mountain, but Hal has aggravated an old knee injury and can't make it back down.Gabe makes it to the top of the peak where Hal and Sarah are. The chopper drops Gabe a cable, which he secures, while the chopper lands on a nearby peak. All is set for the three to shuttle across the cable to where the chopper is. There is a lot of light-hearted banter as this is a routine operation that they all (except Sarah) do all the time. Hal goes first, and as he is crossing, Gabe asks Sarah how Hal persuaded her to accompany him on this escapade. She replies laconically, "He told me it's better than sex."Hal makes it across and now it's Sarah's turn. She is a little frightened at the thought of hanging from a cable 4,000 feet above the ground, but the fact that Hal crossed without incident is reassuring. Halfway across her equipment fails and suddenly she is hanging by a strap and unable to reach and grab onto the cable. Gabe quickly crosses to her and grabs her arm just as the strap breaks free. But they are unable to keep their grip on each other, and Sarah falls 4,000 feet to her death. This is by far the most dramatic and gripping scene in the movie and some viewers will be haunted by it for weeks afterwards. But really, except for providing some background for the interpersonal dynamics among the remaining characters, it has nothing to do with the plot of the rest of the movie.Fast forward eight months, and we pick up two different plot lines that will converge later. At the U.S. Treasury office in Denver, Treasury Agent Travers is preparing to leave on a flight with several large containers of printed currency totaling $100,000,000. His boss introduces FBI Agent Matheson, who is being transferred and is bumming a ride on the flight. Gabe, meanwhile, drives up to Jessie's (and formerly his) house. He had left after Sarah's funeral because he felt he had to get away, and has been working in Denver. He wants Jessie to come to Denver with him, but she won't. She leaves for work, leaving Gabe to get his stuff from the house and load it into his vehicle.On the plane, Matheson looks out his window and sees another plane flying next to them. He quickly and correctly sizes up the situation, informs the other two Treasury agents that Travers intends to hijack the plane, and pulls his gun on Travers. The other two agents dutifully pull their guns on Matheson, as does Travers. Travers shoots the other two agents, then shoots Matheson. In the cockpit, the co-pilot comments about the gunfire, and the pilot shoots him. The two planes move into position and run a cable between them. Travers transfers over, then the pilot sends the containers.But Matheson isn't dead. He manages to shoot the pilot, shoot the cable in enough places that it detaches from both planes and the containers fall to the ground, and shoot the other plane enough times that it crashes in the mountains, before his own plane explodes from explosives previously set by Travers. Kristel, the pilot of the other plane, radios for help, reaches Jessie, Hal, and Frank, tells them they are hikers who got lost in a snowstorm, and asks them to send a chopper. But they can't send a chopper because of the storm, so Hal sets off to
Question: Who does Jessie convince to help Hal locate the climbers?
|
[
"sarah",
"gabe"
] |
task469-6bdd82a9c67b48dc991b371260cb5ae6
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Peroxiredoxin 2 (Prx2), a thiol-dependent peroxidase, is the third most abundant protein in the erythrocyte, and its absence in knock-out mice gives rise to hemolytic anemia. We have found that in human erythrocytes, Prx2 was extremely sensitive to oxidation by H(2)O(2), as dimerization was observed after exposure of 5 x 10(6) cells/mL to 0.5 muM H(2)O(2). In contrast to Prx2 in Jurkat T lymphocytes, Prx2 was resistant to overoxidation (oxidation of the cysteine thiol to a sulfinic/sulfonic acid) in erythrocytes. Reduction of dimerized Prx2 in the erythrocyte occurred very slowly, with reversal occurring gradually over a 20-minute period. Very low thioredoxin reductase activity was detected in hemolysates. We postulate that this limits the rate of Prx2 regeneration, and this inefficiency in recycling prevents the overoxidation of Prx2. We also found that Prx2 was oxidized by endogenously generated H(2)O(2), which was mainly derived from hemoglobin autoxidation. Our results demonstrate that in the erythrocyte Prx2 is extremely efficient at scavenging H(2)O(2) noncatalytically. Although it does not act as a classical antioxidant enzyme, its high concentration and substrate sensitivity enable it to handle low H(2)O(2) concentrations efficiently. These unique redox properties may account for its nonredundant role in erythrocyte defense against oxidative stress.
Question: What type of enzyme is peroxiredoxin 2 (PRDX2)?
|
[
"antioxidant"
] |
task469-ed598a119e9b40b7ac4d285776deddf8
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: It's time to be water efficient! As populations increase across Australia and the rest of the world, demand for water will also increase. If we don't reduce each individual's demand for water (both directly and through embodied water) the water situation will become dire. It is obvious that we cannot increase demands for water much more without detrimental effects to the environment, society and the economy. It's all too easy to blame someone else for the water situation -"if 70% of water is used for agriculture then that's what we should target" - but it's not that easy. We all depend on the food and resources that agriculture provides, and while there are definitely opportunities to increase water efficiency on the farm, the solution will take more than that. We each share responsibility for the sustainable management of our water resources, which means using less water at home, in the workplace, at school, on holidays, on the farm, ... everyone, everywhere, every time. It's time to become water efficient! This involves reassessing our relationship with water, and learning to use it more sparingly. On the most basic level, it requires a behavioural change, and assigning a value to water that truly reflects its worth. We can also unlock economic benefits of being water efficient. There are many real world examples given in the case studies on this site. Everybody has a responsibility to save water, if future generations are to enjoy a similar standard of living to the one we enjoy now. In fact, many of the impacts associated with water use are likely to have an effect on our own lives! www.savewater.com.au has been designed to help you respond to the challenge to become water efficient. It acts as a central repository for relevant information and further advice, so that you can actually achieve significant savings. It also showcases those companies with products that will assist you in your goal.
Question: What is the main idea of this passage?
|
[
"it's time to be water efficient."
] |
task469-029a181f65794082b88153e94743aaf9
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The Rams started their season on the road against the Lions. The Rams drew first blood in the first quarter with a 48-yard field goal from Greg Zuerlein to take a 3-0 lead for the only score of that quarter. The Lions then took a 7-3 lead with Joique Bell's 1-yard run for a touchdown in the 2nd quarter. The Rams responded with a 29-yard field goal from Zuerlein as they came up within a point 7-6 before on the Lions' next possession, Matthew Stafford was picked off by Cortland Finnegan and it was returned 31 yards for a touchdown as the Rams retook the lead 13-7. The Lions then responded with Jason Hanson kicking a 41-yard field goal to shorten the Rams' lead to 13-10 at halftime. After the break, the Lions scored first with Jason Hanson kicking a 45-yard field goal to tie the game 13-13 for the only score of the 3rd quarter. However, the Rams moved back into the lead in the 4th quarter with Brandon Gibson's 23-yard catch from Sam Bradford to make it 20-13. The Lions tied the game back up with Kevin Smith running for a touchdown from 5 yards out to tie the game 20-20. The Rams then retook the lead with Greg Zuerlein kicking a 46-yard field goal to make the score 23-20. On their last possession, the Lions moved down the field and Matthew Stafford found Kevin Smith on a 5-yard touchdown pass to make the final score 27-23 as the Rams began their season 0-1.
Question: Who threw the longest touchdown pass?
|
[
"sam bradford"
] |
task469-bc391f97730c4b6ba8fda8434280dacd
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Did you ever make a secret code? One way to make a code is to represent each letter of the alphabet by a different number. Then you can send a coded message by writing words as strings of digits. This is similar to how information is encoded using an electric current. The voltage of the current is changed rapidly and repeatedly to encode a message, called an electronic signal. There are two different types of electronic signals: analog signals and digital signals. Both are illustrated in Figure 23.20. A digital signal consists of pulses of voltage, created by repeatedly switching the current off and on. This type of signal encodes information as a string of 0s (current off) and 1s (current on). This is called a binary ("two-digit") code. DVDs, for example, encode sounds and pictures as digital signals. An analog signal consists of continuously changing voltage in a circuit. For example, microphones encode sounds as analog signals. Electronic components are the parts used in electronic devices such as computers. The components transmit and change electric current. They are made of materials called semiconductors. A semiconductor is a solid crystalusually consisting mainly of siliconthat can conduct current better than an electric insulator but not as well as an electric conductor. Very small amounts of other elements, such as boron or phosphorus, are added to the silicon so it can conduct current. A semiconductor is illustrated in Figure 23.21. There are two different types of semiconductors: n-type and p-type. An n-type semiconductor consists of silicon and an element such as phosphorus that gives the silicon crystal extra electrons. An n-type semiconductor is like the negative terminal in a chemical cell. A p-type semiconductor consists of silicon and an element such as boron that gives the silicon positively charged holes where electrons are missing. A p-type semiconductor is like the positive terminal in a chemical cell. Electronic components contain many semiconductors. Types of components include diodes, transistors, and inte- grated circuits. Each type is described in Table 23.2. Electronic Component Diode Transistor Integrated Circuit (Microchip) Description A diode consists of a p-type and an n-type semicon- ductor placed side by side. When a diode is connected by leads to a source of voltage, electrons flow from the n-type to the p-type semiconductor. This is the only direction that electrons can flow in a diode. This makes a diode useful for changing alternating current to direct current. A transistor consists of three semiconductors, either p- n-p or n-p-n. Current cant flow through a transistor unless a small amount of current is applied to the center semiconductor (through the base). Then a much larger current can flow through the transistor from end to end (from collector to emitter). This means that a transmitter can be used as a switch, with pulses of a small current turning a larger current on and off. A transistor can also be used to increase the amount of current flowing through a circuit. You can learn more about transistors and how they work at this URL: http An integrated circuitalso called a microchipis a tiny, flat piece of silicon that consists of layers of elec- tronic components such as transistors. An integrated circuit as small as a fingernail can contain millions of electronic components. Current flows extremely rapidly in an integrated circuit because it doesnt have far to travel. You can learn how microprocessors are made at this URL: Many of the devices you commonly use are electronic. Electronic devices include computers, mobile phones, TV remotes, DVD and CD players, game systems, MP3 players, and digital cameras. All of these devices use electric current to encode, analyze, or transmit information. Consider the computer as an example of an electronic device. A computer contains microchips with millions of tiny electronic components. Information is encoded as 0s and 1s and transmitted as electrical pulses. One digit (either 0 or 1) is called a bit, which stands for "binary digit." Each group of eight digits is called a byte. A gigabyte is a billion bytes that
Question: tiny flat piece of silicon that contains layers of many electronic components
|
[
"integrated circuit"
] |
task469-3fec74127f4941979e691a0b67098a3a
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Branko Cvetkovic (born 5 March 1984) is a Serbian professional basketball player for Tadamon Zouk of the Lebanese Basketball League.
Question: Which sport does/did Branko Cvetkovic play?
|
[
"basketball"
] |
task469-2d20fee35fee4ed99339c580ebfb29fd
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The Capitol Skyline Hotel is a hotel located near the United States Capitol in Capitol Hill, Washington, D.C. Designed by Morris Lapidus, the hotel opened in November 1962 as the Skyline Inn, and was once part of the Best Western chain.
Question: Who was the architect or designer of Capitol Skyline Hotel?
|
[
"morris lapidus"
] |
task469-2b0515c394014bbb9400361036674964
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Autosomal-recessive hereditary spastic paraplegias (AR-HSP) consist of a genetically diverse group of neurodegenerative diseases characterised by pyramidal tracts dysfunction. The causative genes for many types of AR-HSP remain elusive. We tried to identify the gene mutation for AR-HSP with cerebellar ataxia and neuropathy. This study included two patients in a Japanese family with their parents who are first cousins. Neurological examination and gene analysis were conducted in the two patients and two normal family members. We undertook genome-wide linkage analysis employing single nucleotide polymorphism arrays using the two patients' DNAs and exome sequencing using one patient's sample. We detected a homozygous missense mutation (c.4189T>G, p.F1397V) in the lysosomal trafficking regulator (LYST) gene, which is described as the causative gene for Chediak-Higashi syndrome (CHS). CHS is a rare autosomal-recessive syndrome characterised by hypopigmentation, severe immune deficiency, a bleeding tendency and progressive neurological dysfunction. This mutation was co-segregated with the disease in the family and was located at well-conserved amino acid. This LYST mutation was not found in 200 Japanese control DNAs. Microscopic observation of peripheral blood in the two patients disclosed large peroxidase-positive granules in both patients' granulocytes, although they had no symptoms of immune deficiency or bleeding tendency. We diagnosed these patients as having adult CHS presenting spastic paraplegia with cerebellar ataxia and neuropathy. The clinical spectrum of CHS is broader than previously recognised. Adult CHS must be considered in the differential diagnosis of AR-HSP.
Question: Which mutated gene causes the ChediakHigashi Syndrome?
|
[
"lysosomal trafficking regulator gene",
"lyst gene"
] |
task469-8aa9dab1b6ec4312b35b601c451e3bec
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Baghdad, in 2004, three soldiers of an Army bomb-disposal unit are investigating a report of an improvised explosive device (IED). They use a sophisticated robot drone to examine the device, which consists of several undetonated artillery shells wired together and hidden under plastic/fabric sheets. The unit, led by Sgt. Thompson, decides that they can detonate the IED using plastic explosives that they'll activate from a safe distance. Thompson also says that the explosion won't cause very much property damage and should result in no loss of life.A small cart is affixed to the back of the robot, which is then sent back into the blast zone. Before it can reach the IED, the trailer loses a wheel. Thompson dresses in a bulky bomb suit and walks down to the trailer. He picks it up and carries it to the IED, rigging it properly. As he walks back, his partners, Sgt. Sanborn and Specialist Eldridge, scan the immediate area for anyone they consider suspicious or who may be in the blast zone. When Thompson is about 25 meters from the bomb, but still in the kill zone, Eldridge notices a man running a butcher shop who is using a cellular phone. Eldridge yells to Sanborn and the specialist begins to run toward the man, ordering him to drop his phone. Sanborn tells Eldridge to shoot the man, who presses a sequence of numbers on the phone. The bomb detonates with Thompson still in the kill zone. The overpressure from the bomb kills Thompson despite the bomb suit; a large splash of blood hits the inside of the clear visor on his helmet.Thompson's body is packed into a coffin for shipment home, Sanborn supervises the procedure. He looks over Thompson's possessions for a few moments before the coffin is sealed. Back at the base, Eldridge is sitting in the rec room when the base psychologist, Lt. Col. Cambridge walks in and asks Eldridge how he's feeling (in the wake of Thompson's death). Eldridge is still clearly upset over the incident; he dry fires his rifle several times, suggesting that if he'd shot the man with the cell phone, Thompson might still be alive.A new leader for the team, Sgt. William James, arrives at the base. Sanborn meets him at his housing unit, where James is taking the plywood covers off his windows. When Sanborn suggests that James keep them on because of mortar shrapnel, James tells him that they won't be any good anyway if a mortar shell crashes in through the unit's roof.The next day the team responds to a report of another IED on a narrow street in the city. After the initial investigation, where they link up with the Army platoon that reported the bomb, James is dressed up in a suit similar to the one Thompson wore previously. As James approaches the bomb site, he tosses a smoke grenade, which agitates Sanborn, who can't see James to instruct him further. James also is uncommunicative with his team members, another factor that Sanborn does not appreciate. James finds an artillery shell buried under a small pile of trash. He disarms it easily, and then notices a secondary wire leading away from it. He uncovers the cable and finds it connects to a junction of six more cables. When James pulls on the junction connector, six more shells are uncovered. Another cable leads to a nearby building. James disarms the six new shells; as he does, he notices a man quickly leaving the building, presumably the bomber. James flashes one of the small detonators from one of the shells and smiles at the man, who vanishes from sight. Back at their Humvee, Sanborn tells James that he needs to communicate more during operations and not treat his duty as if it's a solo act. James brushes his teammate off. James does the same later when he and Sanborn talk while grooming themselves for another day's work in the latrine.The team is again called out for another bomb threat. This time, the bomb is in a car parked in front of a United Nations building. When the building is evacuated, James dons
Question: Who do the enemy snipers kill?
|
[
"british team leader",
"james",
"three of the mercenaries",
"not in excerpt"
] |
task469-3d43674a8e81445f82a249cf3c14fafc
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The film is concerned chiefly with four topics: Chemno, where mobile gas vans were first used by Germans to exterminate Jews; the death camps of Treblinka and Auschwitz-Birkenau; and the Warsaw Ghetto, with testimonies from survivors, witnesses, and perpetrators. The sections on Treblinka include testimony from Abraham Bomba, who survived as a barber;[5] Richard Glazar, an inmate; and Franz Suchomel, an SS officer who worked at the camp, who reveals intricate details of the camp's gas chamber. Bomba breaks down while describing how a barber friend of his came across his wife and sister while cutting hair in an anteroom of the gas chamber. Suchomel states he did not know about extermination at Treblinka until he arrived there. This section includes Henryk Gawkowski, who said he drove one of the transport trains while intoxicated with vodka. Gawkowski's photograph appears on the poster used for the film's marketing campaign. Testimonies on Auschwitz are provided by Rudolf Vrba, who escaped from the camp before the end of the war; and Filip Muller, who worked in an incinerator burning the bodies from the gassings. Muller recounts what prisoners said to him, and describes the experience of personally going into the gas chamber: bodies were piled up by the doors 'like stones'. He breaks down as he recalls the prisoners starting to sing while being forced into the gas chamber. Accounts include some from local villagers, who witnessed trains heading daily to the camp and returning empty; they quickly guessed the fate of those on board. Lanzmann also interviews bystanders. He asks whether they knew what was going on in the death camps. Their answers reveal that they did but they justified their inaction by the fear of death. Two survivors of Chemno are interviewed: Simon Srebnik, who was forced to sing military songs to entertain the Nazis; and Mordechai Podchlebnik. Lanzmann also has a secretly filmed interview with Franz Schalling, a German security guard, who describes the workings of Chemno. Walter Stier, a former Nazi bureaucrat, describes the workings of the railways. Stier insists he was too busy managing railroad traffic to notice his trains were transporting Jews to their deaths. The Warsaw ghetto is described by Jan Karski, who worked for the Polish government-in-exile and Franz Grassler, a Nazi administrator who liaised with Jewish leaders. A Christian, Karski snuck into the Warsaw ghetto and escaped to England to try to convince the Allied governments to intervene more strongly on behalf of the Jews, but failed to do so. Memories from Jewish survivors of the Warsaw Ghetto uprising conclude the documentary. Lanzmann also interviews Holocaust historian Raul Hilberg, who discusses the historical significance of Nazi propaganda against the European Jews, and the Nazi development of the Final Solution. The complete text of the film was published in 1985. The man in the poster[edit] During his trip to Poland in July 1978, Lanzmann's crew filmed his conversations with an elderly Polish man by the name of Henryk Gawkowski, who, some 35 years earlier, had worked on the locomotives pulling Holocaust trains to Treblinka during World War II.[6] The photograph used for the film poster shows Gawkoski on a locomotive to Treblinka, but there was no reconstruction of events from his youth: the type of locomotives used in 1943 were different, as was the landscape. The female translator insists on calling him the train's operator (or conductor in Polish); nevertheless, Gawkowski informed that he only shoveled coal into the engine's firebox, and that two German officers were always on every train. What happened to the victims, Gawkowski said, was not his fault, adding emphatically that if he had the opportunity, he would have been the first to slash Hitler's throat.[6]
Question: What were some of director Claude Lanzmann's interviews of his subjects filmed in?
|
[
"holocaust"
] |
task469-db639e319db84ee9ba341674925a3ea4
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Elena Wexler-Kreindler (15 October 1931 -- August 2002) was a Romanian mathematician.
Question: The date of birth of Elena Wexler-Kreindler is?
|
[
"15 october 1931"
] |
task469-f11cb96be45847bb803e30db80a027c4
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: To identify the origin and study the morphology of small supernumerary marker chromosome (sSMC) in Turner syndrome with 45, X/46, X, + mar karyotype. Using the conventional chromosome G-banding technique, 10 cases of Turner syndrome with 45, X/46, X, + mar chromosome karyotype were obtained, dual-color fluorescence in situ hybridization was applied to study the origin and morphology of the sSMC. In the 10 cases of Turner syndrome with 45, X/46, X, + mar karyotype, the sSMC of 7 cases was derived from X chromosome [sSMC(X)], the sSMC of 2 cases was derived from Y chromosome [sSMC(Y)] and the remaining 1 case was derived from the autosome. There were 4 cases of ring(r) chromosomes and 3 of centric minutes (min) in the 7 sSMC (X) cases. In the 2 sSMC(Y), one case was dicentric (dic) and the other was centric minute (min). The sSMC originated from the autosome was a centric minute (min). The origin of sSMC of Turner syndrome with 45, X/46, X, + mar karyotype was almost all from sex chromosomes, and rarely from autosomes. sSMC can exist as isodicentric, ring, or centric minute. The molecular cytogenetic features of the sSMC can provide useful information for genetic counseling, prenatal diagnosis and treatment of the Turner syndrome patients with a 45, X/46, X, + mar karyotype.
Question: What chromosome is affected in Turner's syndrome?
|
[
"x"
] |
task469-47c684ee2efc42efb19ea114d8ec9514
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Ice is an example of solid matter. A solid is matter that has a fixed volume and a fixed shape. Figure 4.3 shows examples of matter that are usually solids under Earth conditions. In the figure, salt and cellulose are examples of crystalline solids. The particles of crystalline solids are arranged in a regular repeating pattern. The steaks and candle wax are examples of amorphous ("shapeless") solids. Their particles have no definite pattern. Ocean water is an example of a liquid. A liquid is matter that has a fixed volume but not a fixed shape. Instead, a liquid takes the shape of its container. If the volume of a liquid is less than the volume of its container, the top surface will be exposed to the air, like the oil in the bottles in Figure 4.4. Two interesting properties of liquids are surface tension and viscosity. Surface tension is a force that pulls particles at the exposed surface of a liquid toward other liquid particles. Surface tension explains why water forms droplets, like those in Figure 4.5. Viscosity is a liquids resistance to flowing. Thicker liquids are more viscous than thinner liquids. For example, the honey in Figure 4.5 is more viscous than the vinegar. You can learn more about surface tension and viscosity at these URLs: [Link] [Link] (1:40) MEDIA Click image to the left or use the URL below. URL: Water vapor is an example of a gas. A gas is matter that has neither a fixed volume nor a fixed shape. Instead, a gas takes both the volume and the shape of its container. It spreads out to take up all available space. You can see an example in Figure 4.6. Youre probably less familiar with plasmas than with solids, liquids, and gases. Yet, most of the universe consists of plasma. Plasma is a state of matter that resembles a gas but has certain properties that a gas does not have. Like a gas, plasma lacks a fixed volume and shape. Unlike a gas, plasma can conduct electricity and respond to magnetism. Thats because plasma contains charged particles called ions. This gives plasma other interesting properties. For example, it glows with light. Where can you find plasmas? Two examples are shown in Figure 4.7. The sun and other stars consist of plasma. Plasmas are also found naturally in lightning and the polar auroras (northern and southern lights). Artificial plasmas are found in fluorescent lights, plasma TV screens, and plasma balls like the one that opened this chapter. You can learn more about plasmas at this URL: (2:58). MEDIA Click image to the left or use the URL below. URL: Why do different states of matter have different properties? Its because of differences in energy at the level of atoms and molecules, the tiny particles that make up matter. Energy is defined as the ability to cause changes in matter. You can change energy from one form to another when you lift your arm or take a step. In each case, energy is used to move matter you. The energy of moving matter is called kinetic energy. The particles that make up matter are also constantly moving. They have kinetic energy. The theory that all matter consists of constantly moving particles is called the kinetic theory of matter. You can learn more about it at the URL below. Particles of matter of the same substance, such as the same element, are attracted to one another. The force of attraction tends to pull the particles closer together. The particles need a lot of kinetic energy to overcome the force of attraction and move apart. Its like a tug of war between opposing forces. The kinetic energy of individual particles is on one side, and the force of attraction between different particles is on the other side. The outcome of the "war" depends on the state of matter. This is illustrated in Figure 4.8 and in the animation at this URL: [Link] In solids, particles dont have enough kinetic energy to overcome the force of attraction between them. The particles are packed closely together and cannot move around. All they can do
Question: Which state of matter has particles with the least energy?
|
[
"solid"
] |
task469-a91a00fe54b8421d988d8d54725a7748
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: A novel approach to design selective spleen tyrosine kinase (Syk) inhibitors is described. Inhibition of spleen tyrosine kinase has attracted much attention as a mechanism for the treatment of autoimmune diseases such as asthma, rheumatoid arthritis, and SLE. Fostamatinib, a Syk inhibitor that successfully completed phase II clinical trials, also exhibits some undesirable side effects. More selective Syk inhibitors could offer safer, alternative treatments. Through a systematic evaluation of the kinome, we identified Pro455 and Asn457 in the Syk ATP binding site as a rare combination among sequence aligned kinases and hypothesized that optimizing the interaction between them and a Syk inhibitor molecule would impart high selectivity for Syk over other kinases. We report the structure-guided identification of three series of selective spleen tyrosine kinase inhibitors that support our hypothesis and offer useful guidance to other researchers in the field.
Question: Which enzyme is inhibited by a drug fostamatinib?
|
[
"spleen tyrosine kinase"
] |
task469-96c0df89df9944419d23cb887c30df5f
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Chronic liver injury can result in fibrosis that may progress over years to end-stage liver disease. The most effective anti-fibrotic therapy is treatment of the underlying disease, however when not possible, interventions to reverse or slow fibrosis progression are needed. The aim of this study was to study the safety and tolerability of simtuzumab, a monoclonal antibody directed against lysyl oxidase-like 2 (LOXL2) enzyme, in subjects with hepatitis C virus (HCV), human immunodeficiency virus (HIV), or HCV-HIV co-infection and advanced liver disease. Eighteen subjects with advanced liver fibrosis received simtuzumab 700 mg intravenously every 2 weeks for 22 weeks. Transjugular liver biopsies were performed during screening and at the end of treatment to measure hepatic venous pressure gradient (HVPG) and to stage fibrosis. Treatment was well-tolerated with no discontinuations due to adverse events. No significant changes were seen in HVPG or liver biopsy fibrosis score after treatment. Exploratory transcriptional and protein profiling using paired pre- and post-treatment liver biopsy and serum samples suggested up-regulation of TGF-3 and IL-10 pathways with treatment. In this open-label, pilot clinical trial, simtuzumab treatment was well-tolerated in HCV- and HIV-infected subjects with advanced liver disease. Putative modulation of TGF-3 and IL-10 pathways during simtuzumab treatment merits investigation in future trials.
Question: What is the drug target for Simtuzumab?
|
[
"loxl2"
] |
task469-90c7b7ccdcfa48b4966a9d930b245639
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The Spiritual Exercises of Ignatius of Loyola (Latin original: Exercitia spiritualia) (composed 1522--1524) are a set of Christian meditations, prayers and mental exercises, written by Saint Ignatius of Loyola, a 16th-century Spanish priest, theologian, and founder of the Society of Jesus (Jesuits).
Question: What group was Spiritual Exercises of Ignatius of Loyola a member of?
|
[
"society of jesus"
] |
task469-85eab4f7992f4e81804286191ad7e1f7
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: An earthquake is sudden ground movement caused by the sudden release of energy stored in rocks. Earthquakes happen when so much stress builds up in the rocks that the rocks rupture. The energy is transmitted by seismic waves. Earthquakes can be so small they go completely unnoticed, or so large that it can take years for a region to recover. The description of how earthquakes occur is called elastic rebound theory (Figure 1.1). Elastic rebound theory. Stresses build on both sides of a fault, causing the rocks to deform plastically (Time 2). When the stresses become too great, the rocks break and end up in a different location (Time 3). This releases the built up energy and creates an earthquake. Click image to the left or use the URL below. URL: In an earthquake, the initial point where the rocks rupture in the crust is called the focus. The epicenter is the point on the land surface that is directly above the focus (Figure 1.2). In the vertical cross section of crust, there are two features labeled - the focus and the epicenter, which is directly above the focus. Click image to the left or use the URL below. URL:
Question: when an earthquake happens, we say that its __________ was located 100 miles northwest of san francisco.
|
[
"epicenter"
] |
task469-6d3a6927667245088931fa5d7e66d656
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Starting lineups: HOUSTON - OFFENSE: QB Matt Schaub, LT Duane Brown, LG Wade Smith, C Chris Myers, RG Mike Brisiel, RT Eric Winston, WR Andre Johnson, RB Arian Foster, FB Vonta Leach, TE Joel Dreessen, WR Kevin Walter.Hoping to snap a four-game losing streak the Texans played on home ground for an AFC South rivalry match against the Titans. The Texans took control throughout the game as QB Matt Schaub got a 1-yard TD pass to TE Joel Dreessen, followed by his 2-yard TD pass to WR Andre Johnson. The lead was increased when kicker Neil Rackers hit a 35 and a 33-yard field goal. With the easy win, the Texans improved to 5-6. However, Johnson was ejected following a fight with Titans CB Cortland Finnegan, who was also ejected.
Question: Who kicked the longest field goal?
|
[
"neil rackers"
] |
task469-df0dfbab66db4c1ab54ca7fabf8841c3
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: This categorises Stahlgewitter in amongst other more historical Rock Against Communism groups such as the English band Skrewdriver which played a lending role in the formation of RAC and the fellow German band Landser who are now deemed a ''criminal gang organisation'' in Germany.
Question: What is the city of origin of Stahlgewitter?
|
[
"germany"
] |
task469-ff82ffcdaeee4d63a99650e5792f3ccc
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Intravenous immunoglobulin (IVIG) has shown limited promise so far in human clinical studies on Alzheimer's disease (AD), yet overwhelmingly positive preclinical work in animals and human brain cultures support the notion that the therapy remains potentially efficacious. Here, we elaborate on IVIG neuropreservation by demonstrating that IVIG protects human primary neurons against oxidative stress in vitro and that IVIG preserves antioxidant defense mechanisms in vivo. Based on these results, we propose the following translational impact: If the dosage and treatment conditions are adequately optimized, then IVIG treatment could play a significant role in preventing and/or delaying the progression of neurodegenerative diseases, such as AD. We suggest that IVIG warrants further investigation to fully exploit its potential as an anti-oxidant, neuroprotective and synapto-protecting agent.
Question: What is the administration route of IVIG in Alzheimer's disease patients?
|
[
"intravenous"
] |
task469-7b4fb17166494e00ab141ff2bbc4bddb
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: William I of Hauteville (before 1010 -- 1046), known as William Iron Arm, was a Norman adventurer who was the founder of the fortunes of the Hauteville family.
Question: What family lineage was William Iron Arm part of?
|
[
"hauteville family"
] |
task469-528d1b49f066414ab307ef1f89da843b
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The female reproductive organs include the vagina, uterus, fallopian tubes, and ovaries ( Figure 1.1). The breasts are not shown in this figure. They are not considered reproductive organs, even though they are involved in reproduction. They contain mammary glands that give milk to feed a baby. The milk leaves the breast through the nipple when the baby sucks on it. The vagina is a cylinder-shaped organ found inside of the female body. One end of the vagina opens at the outside of the body. The other end joins with the uterus. During sexual intercourse, sperm may be released into the vagina. If this occurs, the sperm will move through the vagina and into the uterus. During birth, a baby passes from the uterus to the vagina to leave the body. The uterus is a hollow organ with muscular walls. The part that connects the vagina with the uterus is called the cervix. The uterus is where a baby develops until birth. The walls of the uterus grow bigger as the baby grows. The muscular walls of the uterus push the baby out during birth. This drawing shows the organs of the female reproductive system. It shows the organs from the side. Find each organ in the drawing as you read about it in the text. The two ovaries are small, oval organs on either side of the uterus. Each ovary contains thousands of eggs, with about 1-2 million immature eggs present at birth and 40,000 immature eggs present at puberty, as most of the eggs die off. The eggs do not fully develop until a female has gone through puberty. About once a month, on average one egg completes development and is released by the ovary. The ovaries also secrete estrogen, the main female sex hormone. The two fallopian tubes are narrow tubes that open off from the uterus. Each tube reaches for one of the ovaries, but the tubes are not attached to the ovaries. The end of each fallopian tube by the ovary has fingers ( Figure 1.1). They sweep an egg into the fallopian tube. Then the egg passes through the fallopian tube to the uterus. If an egg is to be fertilized, this will occur in the fallopian tube. A fertilized egg then implants into the wall of the uterus, where it begins to develop. An unfertilized egg will flow through the uterus and be excreted from the body.
Question: where does a baby develop until birth?
|
[
"the uterus"
] |
task469-99ad380e86ef4602aceee22a02475cf2
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Huntley Gordon died in Van Nuys, California and was interred in the Forest Lawn Memorial Park Cemetery in Glendale, California.
Question: What is the place of burial for Huntley Gordon?
|
[
"forest lawn memorial park"
] |
task469-80ef32a64729422b8d68f5f07ada893c
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: People should listen to music for no more than one hour a day to protect their hearing, the World Health Organization (WHO) suggests. It says 1.1 billion teenagers and young adults are at risk of permanently damaging their hearing by listening to "too much, too loudly". It said audio devices , concerts and bars were causing a "serious threat". WHO figures show 43 million people aged 12-35 have hearing loss and the number is increasing. In that age group, the WHO said, half of the people in rich and middle-income countries were exposed to unsafe sound levels from personal audio devices. Meanwhile 40% were exposed to damaging levels of sound from clubs and bars. The proportion of US teenagers with hearing loss went from 3.5% in 1994 to 5.3% in 2006. "What we're trying to do is raise awareness of the problem that is not talked about enough, but has the potential to do a lot of damage that can be easily prevented," said Dr Etienne Krug, the WHO's director for injury prevention. The full report argued: "While it is important to keep the volume down, limiting the use of personal audio devices to less than one hour a day would do much to reduce noise exposure." Dr Krug said: "That's a rough recommendation, it is not by the minute, to give an idea to those spending 10 hours a day listening to an mp3-player. But even an hour can be too much if the volume is too loud."
Question: How many people aged 12-35 were most likely to suffer from hearing loss according to WHO?
|
[
"40%."
] |
task469-0728ee931b2d404fa4da726c9c6ae5a3
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: When once-wealthy string magnate Rudolf Smuntz (William Hickey) dies, he leaves his outdated string factory and a run-down mansion to his two sons, Lars (Lee Evans) and Ernie (Nathan Lane). When Lars refuses a proposal by representatives from the large Zeppco conglomerate to purchase their string factory, his wife April (Vicki Lewis) throws him out. Meanwhile, Ernie serves Mayor McKrinkle (Cliff Emmich) at his restaurant in anticipation of becoming a famous chef for serving such a high-profile guest. However, the mayor is poisoned by a cockroach (which came from Rudolf's old box of Cuban cigars that Ernie took for himself) and suffers two heart attacks, with the latter fatal. As a result, Ernie's restaurant is closed down by the Board of Health. Finding blueprints of the mansion that they decide to live in, Ernie and Lars discover that it is a lost masterpiece designed by famous architect Charles Lyle LaRue. LaRue collector Alexander Falko (Maury Chaykin) makes a proposal, but Ernie refuses under the belief they can make a larger profit by restoration and auction. However, the brothers have already realized that the house has one stubborn occupant: a tiny and treacherous mouse. When a single mousetrap proved to be useless against the mouse, Ernie and Lars cover the entire kitchen floor with a number of mousetraps, but end up trapped in the kitchen when the door is locked. The mouse slips through the maze of traps with ease and drops a cherry, setting off the mousetraps in a dominoes effect. The brothers attempt to kill the mouse with a vacuum cleaner, but are covered with sewage. The brothers purchase a monstrous cat named "Catzilla" to deal with the mouse. Catzilla chases the mouse throughout the house while destroying everything, but gets tricked onto the house's dumbwaiter as the mouse sends him on a one-way trip down to his demise. They then hire an eccentric exterminator named Caesar (Christopher Walken) to handle the mouse, though he is severely injured and hospitalized. Later, Ernie chases the mouse up a chimney and gets stuck, and Lars attempts to light a match while the mouse starts a gas leak, creating an explosion that blasts Ernie out of the chimney and into the lake. Ernie takes a shotgun to fire at the mouse, accidentally shooting a compressed can of pesticide that Caesar left behind, making a large hole. After the two recover, Lars throws an orange at Ernie, but accidentally knocks the mouse unconscious. Unable to finish him off, they instead seal the mouse in a box and mail him to Fidel Castro in Cuba. The brothers reconcile again and finish renovating the house. When the night of the auction arrives, Lars discovers the mouse's box in the snow returned due to insufficient postage and with a big hole gnawed through it. Lars and Ernie panic upon seeing the mouse return, but attempt to maintain their composure as the auction continues. The mouse also devours Rudolf's "lucky string," which he gave to the brothers before his death, making their vendetta even more personal. The brothers desperately attempt to flush out the mouse by feeding a hose into the wall. As the auction reaches a record $25 million bid, the house rapidly floods through the walls and the floors, causing everyone to be washed out of the house as it promptly collapses. The brothers' only consolation is the fact that the mouse must finally be dead as their father's "lucky string" is found in the wreckage. With nowhere else to go, the brothers return to the factory and fall asleep, with only a single chunk of cheese for food. Having followed them, the mouse restarts and feeds the cheese into the machinery inventing the world's first string cheese, which inspires Ernie and Lars. Ernie and Lars end their war with the mouse and have successfully rebuilt the factory as a novelty string cheese company. Lars has begun a relationship with one of the two sisters Hilde, and Ernie puts his culinary skill to work in developing new cheese flavors with the mouse as his personal taste-tester.
Question: Who does Ernie accidentally kill?
|
[
"the mayor"
] |
task469-5cd56e752c7d492aa1b4d3a4d95d62a5
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The film explores adolescent issues through the minds of three friends and their reactions after a boy named Rudy Carges (Conor Donovan) is killed in a tree house set on fire by local bullies Jeff and Kenny, who carelessly didn't find out he was inside until too late. The boy's twin brother Jacob, a boy with a huge birthmark (also played by Donovan), decides to seek revenge against the bullies. Leonard (Jesse Camacho) who's overweight, survives the tree house fire but loses his sense of taste and smell. Thanks to the fire, this prompts Leonard to go on a diet, which isn't welcomed by his obese family. The boys' female friend Malee (Zoe Weizenbaum) tries to befriend an adult named Gus (Jeremy Renner), a grief-stricken patient of her therapist mother, Carla (Annabella Sciorra). Jacob's family falls apart after the death of his brother. But shortly after, his parents adopt a boy named Keith Gardner. Meanwhile, Malee begins to have a crush on Gus and changes the song for her recital to one Gus liked, just for him. As time goes by, she sees Gus as her "soul mate". She sneaks into his house one night to find him grieving. Afraid to confront him, Malee steals his gun and leaves. She gives it to Jacob the following day. Jacob frequently visits Jeff and Kenny, who are serving time in a juvenile hall. Jacob initially threatens them, until eventually Jeff commits suicide. Jacob befriends Kenny, soon learning he has an early release and is illegally moving to New Mexico. Meanwhile, Leonard's father decides to take his sisters to Florida instead of Leonard (who would usually go). Leonard decides to force his mother to lose weight by trapping her in the cellar. They both end up in the hospital after a gas leak in their home. Next, Jacob and Kenny agree that Jacob can go with him to New Mexico. Malee visits Gus and removes her clothes in an attempt to seduce him. Instead, Gus calls Malee's mother to come and pick her up. The next day, Gus explains to therapist Carla about the last fire he ever fought (which involved killing an injured little girl, upon the girl's request), claiming that Malee wanted him to take her pain away, as he was aware of her growing crush on him. Meanwhile, Jacob's mother tells him that Keith Gardner wasn't adopted to replace Rudy, and that she wants Kenny dead, which reminds Jacob of his planned revenge. The night of escape for Jacob finally comes and he meets up with Kenny. Jacob insists on going through a construction site which he says is a secret route. Once there, Jacob points Gus's gun at Kenny, and tells him "you killed him" before shooting him dead. Jacob buries the body and leaves. He returns in the daytime, and sees Gus spreading cement above Kenny's grave. Malee begins visiting her estranged father and Leonard's family finally starts eating healthily. The movie ends with Jacob's mother smiling at him from inside the house.
Question: Who does Rudy want to meet in the treehouse?
|
[
"leonard"
] |
task469-c4983a83076b417e8dc076b6ce1224b6
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancers are associated with increased sensitivity of these cancers to drugs that inhibit EGFR kinase activity such as gefitinib and erlotinib. Responses to TK inhibitors in the absence of EGFR gene mutation for BAC patients have not been reported. A case of a patient with BAC refractory to chemotherapy who responded to gefitinib in the absence of EGFR gene mutations is reported. Tyrosine kinase inhibitors may have a role in BAC in the absence of EGFR gene mutations. Additional studies on other molecular alterations of the EGFR family members are needed to better predict response to these agents.
Question: Mutations in which gene determine response to both erlotinib and gefitinib?
|
[
"epidermal growth factor receptor (egfr) gene"
] |
task469-15b35d7301d54e4987278e4be65d56fa
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The Chargers' fourteenth game was an interconference duel with the 49ers which was played on Thursday Night. The Chargers took a quick lead with QB Philip Rivers throwing a 58-yard TD pass to WR Vincent Jackson. The lead was extended in the second quarter by kicker Nate Kaeding nailing a 25-yard field goal, followed by Rivers finding Jackson on an 11-yard touchdown pass. The Chargers continued to dominate with FB Mike Tolbert getting a 1-yard TD run, followed by Rivers connecting to Jackson on a 48-yard TD pass, then with Kaeding hitting a 39-yard field goal. The 49ers made their only score of the game with RB Brian Westbrook getting a 1-yard TD run. This game was also a blowout and San Diego improved to 8-6.
Question: How many yards was the longest touchdown pass?
|
[
"58-yard"
] |
task469-cacaa3805c6b4920bed7ed5ded2da586
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Like water and carbon, nitrogen is also repeatedly recycled through the biosphere. This process is called the nitrogen cycle. Nitrogen is one of the most common elements in living organisms. It is important for creating both proteins and nucleic acids, like DNA. The air that we breathe is mostly nitrogen gas (N2 ), but, unfortunately, animals and plants cannot use the nitrogen when it is a gas. In fact, plants often die from a lack of nitrogen even through they are surrounded by plenty of nitrogen gas. Nitrogen gas (N2 ) has two nitrogen atoms connected by a very strong triple bond. Most plants and animals cannot use the nitrogen in nitrogen gas because they cannot break that triple bond. In order for plants to make use of nitrogen, it must be transformed into molecules they can use. This can be accomplished several different ways ( Figure 1.1). Lightning: When lightening strikes, nitrogen gas is transformed into nitrate (NO3 ) that plants can use. Nitrogen fixation: Special nitrogen-fixing bacteria can also transform nitrogen gas into useful forms. These bacteria live in the roots of plants in the pea family. They turn the nitrogen gas into ammonium (NH4 + ) (a process called ammonification). In water environments, bacteria in the water can also fix nitrogen gas into ammonium. Ammonium can be used by aquatic plants as a source of nitrogen. Nitrogen also is released to the environment by decaying organisms or decaying wastes. These wastes release nitrogen in the form of ammonium. Ammonium in the soil can be turned into nitrate by a two-step process completed by two different types of bacteria. In the form of nitrate, nitrogen can be used by plants through the process of assimilation. It is then passed along to animals when they eat the plants. Turning nitrate back into nitrogen gas, the process of denitrification, happens through the work of denitrifying bacteria. These bacteria often live in swamps and lakes. They take in the nitrate and release it back to the atmosphere as nitrogen gas. Just like the carbon cycle, human activities impact the nitrogen cycle. These human activities include the burning of fossil fuels, which release nitrogen oxide gasses into the atmosphere. Releasing nitrogen oxide back into the atmosphere leads to problems like acid rain.
Question: the initial step of producing a nitrogen containing compound from nitrogen in the soil is
|
[
"ammonification."
] |
task469-b6b014dda96a418d93c3e9d239c6a765
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Chronic myeloid leukaemia (CML) is a genetically associated malignancy of haematopoietic stem cells, characterized by a t(9;22) translocation that forms the Philadelphia chromosome and creates a novel fusion gene, BCR-ABL. Treatment with molecular-targeted therapy is usually initiated with imatinib, an inhibitor of BCR-ABL tyrosine kinase. Imatinib resistance is, however, observed in some CML patients, especially in those with advanced disease. Through computerized literature searches, a systematic analysis was conducted to examine the efficacy and benefits of dasatinib therapy for imatinib resistant or intolerant CML patients in the chronic phase (CP), accelerated phase (AP) and fatal blast crisis phase (BC). In terms of major haematological and cytogenetic responses, this meta-analysis showed no significant differences in dasatinib treatment between myeloid BC-CML and lymphoid BC-CML patients with imatinib resistance or intolerance. Dasatinib therapy was, however, significantly more effective in improving major haematological and cytogenetic responses for CP-CML patients than for AP-CML patients with imatinib resistance or intolerance.
Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
|
[
"bcr-abl"
] |
task469-38c7f2ab0e1d458991162b767f294699
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: To understand what satellites can do, lets look at an example. One of the deadliest hurricanes in United States history hit Galveston, Texas in 1900. The storm was first spotted at sea on Monday, August 27th , 1900. It was a tropical storm when it hit Cuba on September 3rd . By September 8th , it had intensified to a hurricane over the Gulf of Mexico. It came ashore at Galveston (Figure 2.34). Because there was not advanced warning, more than 8000 people lost their lives. Today, we have satellites with many different types of instruments that orbit the Earth. With these satellites, satellites can see hurricanes form at sea. They can follow hurricanes as they move from far out in the oceans to shore. Weather forecasters can warn people who live along the coasts. These advanced warning give people time to prepare for the storm. They can find a safe place or even evacuate the area, which helps save lives. Satellites orbit high above the Earth in several ways. Different orbits are important for viewing different things about the planet. A satellite in a geostationary orbit flies above the planet at a distance of 36,000 km. It takes 24 hours to complete one orbit. The satellite and the Earth both complete one rotation in 24 hours. This means that the satellite stays over the same spot. Weather satellites use this type of orbit to observe changing weather conditions over a region. Communications satellites, like satellite TV, use this type of orbit to keep communications going full time. Another useful orbit is the polar orbit (Figure 2.35). The satellite orbits at a distance of several hundred kilometers. It makes one complete orbit around the Earth from the North Pole to the South Pole about every 90 minutes. In this same amount of time, the Earth rotates only slightly underneath the satellite. So in less than a day, the satellite can see the entire surface of the Earth. Some weather satellites use a polar orbit to see how the weather is changing globally. Also, some satellites that observe the land and oceans use a polar orbit. The National Aeronautics and Space Administration (NASA) has launched a fleet of satellites to study the Earth (Figure 2.36). The satellites are operated by several government agencies, including NASA, the National Oceano- graphic and Atmospheric Administration (NOAA), and the United States Geological Survey (USGS). By using different types of scientific instruments, satellites make many kinds of measurements of the Earth. Some satellites measure the temperatures of the land and oceans. Some record amounts of gases in the atmosphere, such as water vapor and carbon dioxide. Some measure their height above the oceans very precisely. From this information, they can measure sea level. Some measure the ability of the surface to reflect various colors of light. This information tells us about plant life. Some examples of the images from these types of satellites are shown in Figure 2.37. In order to locate your position on a map, you must know your latitude and your longitude. But you need several instruments to measure latitude and longitude. What if you could do the same thing with only one instrument? Satellites can also help you locate your position on the Earths surface. By 1993, the United States military had launched 24 satellites to help soldiers locate their positions on battlefields. This system of satellites was called the Global Positioning System (GPS). Later, the United States government allowed the public to use this system. Heres how it works. You must have a GPS receiver to use the system (Figure 2.38). You can buy many types of these in stores. The Prior to the late 20th and early 21st centuries, mapmakers sent people out in the field to determine the boundaries and locations for various features for maps. State or county borders were used to mark geological features. Today, people in the field use GPS receivers to mark the locations of features. Map-makers also use various satellite images and computers to draw maps. Computers are able to break apart the fine details of a satellite image, store the pieces of information, and put them back together to make a map.
Question: type of orbit that allows a satellite to see all of Earths surface in less than a day
|
[
"polar orbit"
] |
task469-28a1fa15e04f4ea68550ad0f87c09f9e
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: In week 11 following their bye-week, the Lions hosted the Jacksonville Jaguars. The Jaguars opened the scoring in the first quarter via a 27-yard field goal from Jason Myers. The Lions' first score came in the second quarter on a 55-yard punt return from Andre Roberts, but the extra point try by Matt Prater was partially blocked and failed. The Jaguars responded with a three-yard touchdown pass from Blake Bortles to Allen Robinson, but the conversion attempt by Myers also failed. The Lions then scored on a 27-yard field goal from Matt Prater, which tied the score at 9-9 at halftime. The Lions took the lead in the third quarter via a 39-yard interception return from Rafael Bush. The Jaguars responded with 10 points in the third quarter via a 52-yard field goal from Myers, and a three-yard touchdown pass from Bortles to Marqise Lee, giving them a 19-16 lead. The Lions, trailing for the ninth straight game when entering the fourth quarter, would score the final 10 points of the game. The Lions offense scored its first and only touchdown on a one-yard run from Eric Ebron, and Matt Prater added a 43-yard field goal with 22 seconds left in the game. On the final drive for the Jaguars, Tavon Wilson intercepted a pass from Bortles, sealing the Lions 26-19 victory. The Lions became the first team in NFL history to have its first ten games of a season all decided by seven or fewer points.
Question: Who scored first?
|
[
"jaguars"
] |
task469-8e707f475fe348e1ba506b0dc45938f7
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Academy-bus driver Jang Kyung-chul happens upon Jang Joo-yun one snowy night and offers to help fix her flat tire. Kyung-chul kills her and scatters her body parts. When a boy discovers one of Joo-yun's ears, the police are called in under the command of Section Chief Oh and Squad Chief Jang, the latter of whom is the father of Joo-yun. Kim Soo-hyun, a secret service agent of the National Intelligence Service (NIS) and Joo-yun's fiance, vows to track down and take vengeance on Joo-yun's murderer. Jang supplies Soo-hyun with a list of four suspects, including Kyung-chul. Searching Kyung-chul's home, Soo-hyun finds jewelry and underwear taken from (apparently) numerous victims. The discovery of Joo-yun's engagement ring proves that Kyung-chul is the killer. Soo-hyun puts a tracking device on the academy bus, following then attacking Kyung-chul while he is sexually assaulting his latest victimone of the schoolgirls he was transporting home. Beating him unconscious, Soo-hyun places an NIS transmitter inside Kyung-chul, allowing him to track him on radar and listen to his conversations. Waking up, Kyung-chul flags down a taxi. During the ride, Kyung-chul realizes that the two men in the cab are thugs looking to rob and possibly kill him; he stabs both men to death. After finding the real taxi driver in the trunk, Kyung-chul disposes of all three bodies before going to a medical center, where he attempts to sexually assault a nurse Han Song-yi. Soo-hyun intervenes and slashes Kyung-chul's Achilles tendon before letting him go again. Kyung-chul goes to the home of his friend Tae-joo, a cannibalistic murderer. After explaining his situation, Tae-joo remarks that whoever is after him must have some relation to one of his victims. Soo-hyun arrives, proceeding to incapacitate both murderers along with Tae-joo's girlfriend Se-jung. The next day, both Tae-joo and Se-jung are found by the police and sent to a hospital. A trusted subordinate of Soo-hyun's ensures he and Kyung-chul are sent to a private medical area away from the police. The barely conscious Kyung-chul hears them talk about the transmitter inside him. Soo-hyun dumps Kyung-chul, intending to continue stalking him. Kyung-chul taunts him over the transmitter, now knowing who he is. Kyung-chul brutally assaults a store owner, forcing Soo-hyun to rush to the aid of the victim. Kyung-chul uses this time to defecate out the transmitter and place it inside a taxi driver he viciously assaults. Soo-hyun interrogates Tae-joo and learns that Kyung-chul is going after Joo-yun's father Jang and sister Jang Se-yun. Soo-hyun arrives too late to stop Kyung-chul, who blinds Jang with a dumbbell and mutilates Se-yun. He abducts Kyung-chul before he can turn himself over to the police. Soo-hyun tortures him physically and mentally before setting up a guillotine above Kyung-chul's head that is soon activated when his parents and son arrive to visit and open the door to the room he is in. Placing a transmitter nearby, Soo-hyun's hears the death of Kyung-chul and his family's reaction to his decapitated corpse. Alternating between sobbing and fits of laughter, Soo-hyun suffers a mental breakdown while walking away from the house.
Question: Who is Kyung-chul?
|
[
"academy bus driver",
"academy-bus driver"
] |
task469-e49219c4c6894d659f7a16f093c5ee42
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Waking Ned (titled Waking Ned Devine in North America) is a 1998 comedy film by English writer and director Kirk Jones.
Question: Which is the publication date of Waking Ned?
|
[
"1998"
] |
task469-abc7eae7f13f427cbc3b241900238bb4
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Trying to snap a three-game losing streak, the 49ers flew to Giants Stadium for a Week 7 brawl with the New York Giants. With QB Alex Smith still recovering from a shoulder injury, back-up Trent Dilfer once again got the start. In the first quarter, the Niners trailed early as Giants QB Eli Manning hooked up with WR Amani Toomer on a 4-yard TD pass (with a missed PAT) for the only score of the period. In the second quarter, San Francisco took the lead with Dilfer completing a 17-yard TD pass to WR Arnaz Battle. However, New York responded with RB Brandon Jacobs getting a 5-yard TD run, while kicker Lawrence Tynes nailed field goals of 29 and 39 yards. In the third quarter, things got worse for the Niners as Giants DE Osi Umenyiora sacked Dilfer, causing a fumble, picked up the loose ball, and ran 75 yards for a touchdown. San Francisco would manage to get a safety as FB Moran Norris blocked a punt, which went out of bounds in the endzone. In the fourth quarter, New York sealed its win with Manning completing a 2-yard TD pass to TE Jeremy Shockey. The Niners ended its day with Dilfer completing a 1-yard TD pass to WR Darrell Jackson (with a failed 2-point conversion).
Question: Which receiver had the longest touchdown reception of the game?
|
[
"arnaz battle"
] |
task469-6c181cd943a24920bb8b21a3bcf6a978
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Gino Coutinho (born 5 August 1982) is a Dutch footballer, who plays as a goalkeeper for AZ in the Dutch Eredivisie.
Question: What position does Gino Coutinho play on the field?
|
[
"goalkeeper"
] |
task469-6c3158bfa90d42efb06addc85ba3d1f2
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Coming off their special teams woes in 2010, the Chargers allowed a 103-yard opening kickoff return to Percy Harvin to start the season. Kicker Nate Kaeding suffered a season-ending injury on the play, and punter Mike Scifres assumed place kicking responsibilities for the game. The Chargers outscored the Vikings 10-0 in the fourth quarter to come back and win the game, 24-17. Fullback Mike Tolbert scored three touchdowns, and Philip Rivers completed 33 of 48 passes for 335 yards and two touchdowns. He was also intercepted twice. Scifres kicked a 40-yard field goal, the first of his NFL career, and kicked three PATs. With the win, the Chargers started their season out 1-0.
Question: Which player scored the longest touchdown of the game?
|
[
"percy harvin"
] |
task469-1e03ac4451074a6ba1661f0a669109e1
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Sibton Abbey, an early Cistercian abbey located near Yoxford, Suffolk, was founded about 1150 by William de Chesney, High Sheriff of Norfolk and Suffolk.
Question: What group was Sibton Abbey a member of?
|
[
"cistercian"
] |
task469-3c1d5a3656204f0aa80d5159a1ceea56
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The Steelers' ninth game was an AFC duel with the Patriots. The Steelers trailed early as QB Tom Brady made a 19-yard TD pass to TE Rob Gronkowski. This was followed by kicker Shayne Graham getting a 31-yard field goal. The Steelers responded in the second quarter with kicker Jeff Reed nailing a 22-yard field goal. The Steelers struggled further when Brady threw another TD pass to Gronkowski, this one from 9yards out. That was followed by Brady's scramble 3yards to the endzone for a touchdown (With a failed PAT as the kick went wide-right). The Steelers scored first in the 4th quarter when QB Ben Roethlisberger completed a 6-yard TD pass to WR Emmanuel Sanders. The Steelers looked to create another scoring drive, but it came to a halt when Roethlisberger's pass was intercepted by SS James Sanders and returned 32yards for a touchdown (With a failed 2-point conversion). The Steelers tried to cut the lead with a Roethlisberger 15-yard TD pass to WR Mike Wallace, but the Patriots replied with Brady getting a 25-yard TD pass to Gronkowski. Again the Steelers tried to get closer when Roethlisberger completed a 33-yard TD pass to Wallace, but the Patriots put the game away after Graham hit a 36-yard field goal.
Question: Who threw the longest touchdown pass of the game?
|
[
"roethlisberger"
] |
task469-6e767ac3095242a9a25122e045157939
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: A Task Force was established by the International Restless Legs Syndrome Study Group (IRLSSG) to develop evidence-based and consensus-based recommendations for the long-term pharmacologic treatment of restless legs syndrome/Willis-Ekbom disease (RLS/WED). The Task Force reviewed the results of all studies of RLS/WED treatments with durations of 6 months or longer presented at meetings over the past 2 years, posted on Web sites of pharmaceutical companies, or published in peer-reviewed journals, asking the questions, "What is the efficacy of this treatment in patients with RLS/WED?" and "What is the safety of this treatment in patients with RLS/WED?" The Task Force developed guidelines based on their review of 61 papers meeting inclusion criteria, and using a modified evidence-grading scheme. Pregabalin has been established as effective for up to 1 year in treating RLS/WED (Level A evidence). Pramipexole, ropinirole, and rotigotine have been established as effective for up to 6 months in treating RLS/WED (Level A). The following drugs have been established as probably effective (Level B) in treating RLS/WED for durations ranging from 1 to 5 years: gabapentin enacarbil, pramipexole, and ropinirole (1 year); levodopa (2 years); and rotigotine (5 years). Because of associated safety concerns, pergolide and cabergoline should not be used in the treatment of RLS/WED unless the benefits clearly outweigh the risks. Other pharmacologic therapies have insufficient evidence to support their long-term use in treating RLS/WED. The IRLSSG Task Force also developed consensus-based strategies for the prevention and treatment of complications (such as augmentation, loss of efficacy, excessive daytime sleepiness, and impulse control disorders) that may develop with the long-term pharmacologic treatment of RLS/WED. The use of either a dopamine-receptor agonist or 2 calcium-channel ligand is recommended as the first-line treatment of RLS/WED for most patients, with the choice of agent dependent on the patient's severity of RLS/WED symptoms, cognitive status, history, and comorbid conditions.
Question: Willis-Ekbom disease is also known as?
|
[
"restless legs syndrome"
] |
task469-4543715d3d964432b02efbfe6b39b331
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Thomas Magnay (14 September 1876 -- 3 November 1949) was a Liberal Party politician in the United Kingdom, who joined the breakaway Liberal National faction and served as a Member of Parliament (MP) from 1931 to 1945.
Question: Which country's citizen was Thomas Magnay?
|
[
"united kingdom"
] |
task469-733bacb081504caabe26b532cba6d051
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: From the outside, the skin looks plain and simple, as you can see in Figure 16.5. But at a cellular level, theres nothing plain or simple about it. A single square inch of skin contains about 20 blood vessels, hundreds of sweat glands, and more than a thousand nerve endings. It also contains tens of thousands of pigment-producing cells. Clearly, there is much more to skin than meets the eye! For a dramatic introduction to the skin, watch this video: MEDIA Click image to the left or use the URL below. URL: The skin is only about 2 mm thick, or about as thick as the cover of a book. Although it is very thin, it consists of two distinct layers, called the epidermis and the dermis. You can see both layers and some of their structures in Figure 16.6. Refer to the figure as you read about the epidermis and dermis below. The epidermis is the outer layer of skin. It consists almost entirely of epithelial cells. There are no blood vessels, nerve endings, or glands in this skin layer. Nonetheless, this layer of skin is very active. It is constantly being renewed. How does this happen? 1. The cells at the bottom of the epidermis are always dividing by mitosis to form new cells. 2. The new cells gradually move up through the epidermis toward the surface of the body. As they move, they produce the tough, fibrous protein called keratin. 3. By the time the cells reach the surface, they have filled with keratin and died. On the surface, the dead cells form a protective, waterproof layer. 4. Dead cells are gradually shed from the surface of the epidermis. As they are shed, they are replaced by other dead cells that move up from below. The epidermis also contains cells called melanocytes. You can see a melanocyte in Figure 16.7. Melanocytes produce melanin. Melanin is a brown pigment that gives skin much of its color. Everyones skin has about the same number of melanocytes per square inch. However, the melanocytes of people with darker skin produce more melanin. The amount of melanin that is produced depends partly on your genes and partly on how much ultraviolet light strikes your skin. The more light you get, the more melanin your melanocytes produce. This explains why skin tans when its exposed to sunlight. The dermis is the inner layer of skin. It is made of tough connective tissue. The dermis is attached to the epidermis by fibers made of the protein collagen. The dermis is where most skin structures are located. Look again at Figure pain, pressure, and temperature. If you cut your skin and it bleeds, the cut has penetrated the dermis and damaged a blood vessel. The cut probably hurts as well because of the nerve endings in this skin layer. The dermis also contains hair follicles and two types of glands. You can see some of these structures in Figure 16.8. Hair follicles are structures where hairs originate. Each hair grows out of a follicle, passes up through the epidermis, and extends above the skin surface. Sebaceous glands are commonly called oil glands. They produce an oily substance called sebum. Sebum is secreted into hair follicles. Then it makes its way along the hair shaft to the surface of the skin. Sebum waterproofs the hair and skin and helps prevent them from drying out. Sweat glands produce the salty fluid known as sweat. Sweat contains excess water, salts, and other waste products. Each sweat gland has a duct that passes through the epidermis. Sweat travels from the gland through the duct and out through a pore on the surface of the skin. You couldnt survive without your skin. It has many important functions. In several ways, it helps maintain homeostasis. The main function of the skin is controlling what enters and leaves the body. It prevents the loss of too much water from the body. It also prevents bacteria and other microorganisms from entering the body. Melanin in the epidermis absorbs ultraviolet light. This prevents the light from reaching and damaging the dermis. The skin helps maintain a constant body temperature. It
Question: The dermis consists mainly of
|
[
"connective tissue."
] |
task469-6a04e675461d42be98b46d0d0ac80b6a
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: McLeod syndrome is a rare X-linked neuroacanthocytosis syndrome with hematologic, muscular, and neurologic manifestations. McLeod syndrome is caused by mutations in the XK gene whose product is expressed at the red blood cell (RBC) surface but whose function is currently unknown. A variety of XK mutations has been reported but no clear phenotype-genotype correlation has been found, especially for the point mutations affecting splicing sites. A man suspected of neuroacanthocytosis was evaluated by neurologic examination, electromyography, muscle biopsy, muscle computed tomography, and cerebral magnetic resonance imaging. The McLeod RBC phenotype was disclosed by blood smear and immunohematology analyses and then confirmed at the biochemical level by Western blot analysis. The responsible XK mutation was characterized at the mRNA level by reverse transcription-polymerase chain reaction (PCR), identified by genomic DNA sequencing, and verified by allele-specific PCR. A novel XK splice site mutation (IVS1-1G>A) has been identified in a McLeod patient who has developed hematologic, neuromuscular, and neurologic symptoms. This is the first reported example of a XK point mutation affecting the 3' acceptor splice site of Intron 1, and it was demonstrated that this mutation indeed induces aberrant splicing of XK RNA and lack of XK protein at the RBC membrane. The detailed characterization at the molecular biology level of this novel XK splice site mutation associated with the clinical description of the patient contributes to a better understanding of the phenotype-genotype correlation in the McLeod syndrome.
Question: Mutation of which gene is associated with McLeod syndrome?
|
[
"xk"
] |
task469-2cfe5f01915a488787921ef0aef7fa00
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The opening crawl reveals that Han Solo's friends are engaged in a mission to rescue the smuggler from Jabba the Hutt and that the Galactic Empire is building a new armored space station which is even larger and more powerful than the first Death Star.Near the forest moon of Endor the new Death Star is being constructed in orbit, and a command star destroyer arrives and launches a shuttle with a fighter escort -- a shuttle bearing the Dark Lord of the Sith. Fearing his arrival, the commander of the new Death Star informs Darth Vader (David Prowse, voice: James Earl Jones) that the station will be operational on schedule, but when Vader challenges this "optimistic" appraisal of the situation, the commander admits that he needs more men to accelerate construction. Darth Vader, however, informs the commander that the Emperor (Ian McDiarmid) will be arriving soon, and that he is most displeased with the commander's progress. Shaken, the commander commits to redoubling construction efforts. Vader, pleased, remarks, "the Emperor is not as forgiving as I am."Jedi Knight Luke Skywalker (Mark Hamill), Chewbacca (Peter Mayhew), Lando Calrissian (Billy Dee Williams), Princess Leia Organa (Carrie Fisher), C-3PO (Anthony Daniels), and R2-D2 (Kenny Baker) return to Tatooine to rescue Han Solo (who was encased in carbonite at the end of Star Wars: Episode V - The Empire Strikes Back) from the gangster Jabba the Hutt (voice: Larry Ward). Luke sends C-3PO and R2-D2 to Jabba's desert palace to deliver a message: In a hologram projected by R2, Luke offers to bargain with Jabba for Solo himself -- if Jabba does not, he will be destroyed. Jabba laughs at the message and refuses to give up his "favorite decoration:" Han, frozen in carbonite, hangs on a wall in Jabba's court. The two droids are sent to EV-9D9's workshop where C-3P0 is given the job of Jabba's translator and R2 will be a drink-server on Jabba's sail barge.Disguised as a bounty hunter named Boushh, Leia arrives in Jabba's court with Chewbacca in cuffs. She offers him to Jabba for a sizable bounty. After Leia dickers with Jabba over the amount and threatens him with a small thermal detonator, Jabba happily agrees to pay, impressed with the bounty hunter's nerve, and Chewbacca is imprisoned.That night, Leia sneaks into Jabba's court and frees Han from the carbonite. However, she and Solo are both captured by Jabba. Solo is imprisoned with Chewbacca and Jabba keeps Leia on display in a metal bikini and chains. Luke arrives with a final ultimatum to release Solo. Jabba again refuses and drops Luke through a trap door into a pit below his throne that houses the rancor, a fearsome beast that Jabba keeps for executions. As Leia watches in horror, she sees Lando Calrissian disguised as a palace guard. After a brief battle, Luke defeats the rancor, enraging Jabba, who declares that Luke, Solo and Chewbacca will be slowly consumed by the sarlacc -- a huge, shark-toothed, tentacled maw at the bottom of the Great Pit of Carkoon.The group is taken to the pit on Jabba's sail barge fleet and prepared for execution: Luke is the first, pushed out onto a thin plank over the pit. Luke gives R2 a short salute and a small object, Luke's new lightsaber, is launched into his hand. A battle erupts, with Luke steadily taking the fight to Jabba's men. During the battle, Leia strangles Jabba with the chain around her neck and with R2-D2's help escapes from her bonds. Solo accidentally knocks Boba Fett (Jeremy Bulloch) into the sarlacc pit. Lando is also thrown off one of the skiffs, hanging by a few cables until he's rescued from the sarlacc itself by Han and Chewbacca. Luke, having fought his way onto Jabba's sail barge, has the escaping Leia aim the deck cannon at the vehicle and sets it on automatic fire; the sail barge soon blows apart. Our heroes manage to escape before it explodes, retrieve R2 and C-3PO and zip off into the desert.
Question: Who leads the rebel fleet to the Death Star?
|
[
"lando calrissian"
] |
task469-eb1e94c54eb945808e78cf8d2ef02b14
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Alexander Military Law Academy (Russian: - ) (1867--1917) was an educational institution in Russian Empire that provided military law education for officers of Russian Army and Fleet.
Question: What year did Alexander Military Law Academy end?
|
[
"1917"
] |
task469-a30e4507ef554f88b4445e032982b14a
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Radioactive decay is the breakdown of unstable elements into stable elements. To understand this process, recall that the atoms of all elements contain the particles protons, neutrons, and electrons. An element is defined by the number of protons it contains. All atoms of a given element contain the same number of protons. The number of neutrons in an element may vary. Atoms of an element with different numbers of neutrons are called isotopes. Consider carbon as an example. Two isotopes of carbon are shown in Figure 11.15. Compare their protons and neutrons. Both contain 6 protons. But carbon-12 has 6 neutrons and carbon-14 has 8 neutrons. Almost all carbon atoms are carbon-12. This is a stable isotope of carbon. Only a tiny percentage of carbon atoms are carbon-14. Carbon-14 is unstable. Figure 11.16 shows carbon dioxide, which forms in the atmosphere from carbon-14 and oxygen. Neutrons in cosmic rays strike nitrogen atoms in the atmosphere. The nitrogen forms carbon- 14. Carbon in the atmosphere combines with oxygen to form carbon dioxide. Plants take in carbon dioxide during photosynthesis. In this way, carbon-14 enters food chains. Like other unstable isotopes, carbon-14 breaks down, or decays. For carbon-14 decay, each carbon-14 atom loses an alpha particle. It changes to a stable atom of nitrogen-14. This is illustrated in Figure 11.17. The decay of an unstable isotope to a stable element occurs at a constant rate. This rate is different for each isotope pair. The decay rate is measured in a unit called the half-life. The half-life is the time it takes for half of a given amount of an isotope to decay. For example, the half-life of carbon-14 is 5730 years. Imagine that you start out with 100 grams of carbon-14. In 5730 years, half of it decays. This leaves 50 grams of carbon-14. Over the next 5730 years, half of the remaining amount will decay. Now there are 25 grams of carbon-14. How many grams will there be in another 5730 years? Figure 11.18 graphs the rate of decay of carbon-14. The rate of decay of unstable isotopes can be used to estimate the absolute ages of fossils and rocks. This type of dating is called radiometric dating. The best-known method of radiometric dating is carbon-14 dating. A living thing takes in carbon-14 (along with stable carbon-12). As the carbon-14 decays, it is replaced with more carbon-14. After the organism dies, it stops taking in carbon. That includes carbon-14. The carbon-14 that is in its body continues to decay. So the organism contains less and less carbon-14 as time goes on. We can estimate the amount of carbon-14 that has decayed by measuring the amount of carbon-14 to carbon-12. We know how fast carbon-14 decays. With this information, we can tell how long ago the organism died. Carbon-14 has a relatively short half-life. It decays quickly compared to some other unstable isotopes. So carbon- 14 dating is useful for specimens younger than 50,000 years old. Thats a blink of an eye in geologic time. But radiocarbon dating is very useful for more recent events. One important use of radiocarbon is early human sites. Carbon-14 dating is also limited to the remains of once-living things. To date rocks, scientists use other radioactive isotopes. The isotopes in Table 11.1 are used to date igneous rocks. These isotopes have much longer half-lives than carbon- 14. Because they decay more slowly, they can be used to date much older specimens. Which of these isotopes could be used to date a rock that formed half a million years ago? Unstable Isotope Decays to At a Half-Life of (years) Potassium-40 Uranium-235 Uranium-238 Argon-40 Lead-207 Lead-206 1.3 billion 700 million 4.5 billion Dates Rocks Aged (years old) 100 thousand - 1 billion 1 million - 4.5 billion 1 million - 4.5 billion
Question: using radioactive decay to estimate the age of a fossil or rock
|
[
"radiometric dating"
] |
task469-d8cb8f5ee9844f3ab06f26bc2e101dc2
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Erythrasma is an uncommon vulvar infection, best diagnosed by its fluorescence under the Wood lamp. This report shows that despite a negative Wood lamp examination, the diagnosis can be made histologically. A 42-year-old woman was referred to our clinic with a persistent candidal infection. Evaluation included a Wood lamp examination, wet mount, and potassium hydroxide test of the affected skin, all of which were negative. A biopsy of the area demonstrated rods and filamentous organisms in the keratotic layer consistent with a Corynebacterium minutissimum infection. The patient was diagnosed as having erythrasma, and she responded to oral erythromycin. Persistent vulvar diseases may be caused by erythrasma despite a negative Wood lamp examination. The diagnosis can be made by biopsy of the lesion.
Question: Which bacteria causes erythrasma?
|
[
"corynebacterium minutissimum"
] |
task469-389ff4319d874aef97e04bdea70bb494
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The 19th Light Dragoons was a cavalry regiment of the British Army created in 1781 for service in British India.
Question: What branch was 19th Light Dragoons part of?
|
[
"british army"
] |
task469-6a2bf3967c0c433c8f645aa2b63667f6
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Rose Elliot (Irene Miracle), a poet living alone in New York City, discovers an ancient book called The Three Mothers. It tells of the existence of three evil sisters who rule the world with sorrow, tears, and darkness. The book, written by an architect named Varelli, reveals that the three dwell inside separate homes that had been specially designed and built for them by the architect in Rome, Freiburg, and New York. Rose suspects that she is living in one of the buildings and writes to her brother Mark (Leigh McCloskey), a music student in Rome, urging him to visit her. Using clues provided in Varelli's book as a guide, Rose searches the cellar of her building and discovers a hole in the floor which leads to a water-filled ballroom. After accidentally dropping her keys into the water, she enters the flooded room. Swimming under the surface, she sees a portrait bearing the words "Mater Tenebrarum" and is able to reclaim the keys. A putrid corpse suddenly rises from the depths, frightening her. She escapes, although a shadowy figure watches her leave the basement.In Rome, Mark attempts to read Rose's letter during class. He is distracted by the intense gaze of a beautiful student (Ania Pieroni). When the class ends she leaves suddenly; Mark follows, leaving the letter behind. His friend Sara (Eleonora Giorgi) picks up the letter, and eventually reads it. Horrified by the letter's contents, she takes a taxi to a library and locates a copy of The Three Mothers. While looking for an exit, Sara is attacked by a monstrous figure who recognizes the book. She throws the book to the ground and escapes. Later that night, she seeks the company of a neighbor named Carlo (Gabriele Lavia) and both are stabbed to death by a gloved killer. Mark discovers the bodies and two torn fragments from Rose's letter. After the police arrive, he walks out of Sara's apartment and sees a taxi slowly driving by. In it is the music student, staring at him intently once again.Mark telephones Rose but is unable to hear her clearly. He promises to visit just before the connection fails. Cut off, Rose sees two shadowy figures preparing to enter her apartment. She leaves through a back door, but is followed. In a decrepit room, she is grabbed from behind by a clawed assailant and brutally murdered.Upon arriving in New York, Mark meets some of the residents of Rose's building, including a nurse (Veronica Lazar) who is caring for the elderly Professor Arnold (Feodor Chaliapin, Jr.), a wheelchair-bound mute. Mark learns from the sickly Countess Elise (Daria Nicolodi) that Rose has disappeared. Elise explains how Rose had been acting strangely. After the two find blood on the carpet outside Rose's room, Mark follows the stains. He suddenly becomes ill and falls unconscious. Elise sees a black-robed figure dragging Mark away, but the figure suddenly stops and gives chase to Elise. She is attacked by dozens of cats, who bite and claw at her flesh. The hooded figure then stabs her to death. Mark staggers to the house's foyer where the nurse and caretaker (Alida Valli) put him to bed.The next day, Mark asks Kazanian (Sacha Pitoeff), the antique dealer who sold Rose the Three Mothers book, about Rose. However, the man provides no information. That night, Kazanian drowns several cats in a Central Park pond and accidentally falls into the water. Hundreds of rats from a nearby drain crawl all over him, gnawing his flesh. A hot dog vendor hears Kazanian's cries and rushes over. The man kills Kazanian with a knife.Carol, the caretaker, discovers the horribly mutilated corpse of Elise's butler (Leopoldo Mastelloni) in the Countess' apartment. Shocked, she drops a lit candle which starts a fire. Attempting to put out the flames, she becomes entangled in burning draperies and falls from a window to her death.Meanwhile, Mark uses a clue from Rose's letter to discover that beneath each floor is a secret
Question: Where does Rose live?
|
[
"new york"
] |
task469-f6702a8db2f54edb80fc028c7f2bbee8
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: In the opening scene, private detective Sam Grunion (Groucho Marx) explains to the viewers that he has been searching for the extremely valuable Royal Romanoff diamonds for eleven years, and his investigation leads him to a troupe of struggling performers, led by Mike Johnson (Paul Valentine), who are trying to put on a musical revue called 'Love Happy'.Grunion notes that the impoverished young dancers would starve were it not for the sweet, silent Harpo (Harpo Marx), at Herbert & Herbert, a gourmet food shop that also trafficks in stolen diamonds. Harpo kindly helps ladies with their shopping bags, all the while pilfering their groceries and stuffing them in the pockets of his long trench coat. When the elegant Madame Egelichi (Ilona Massey) arrives, store manager Lefty Throckmorton (Melville Cooper) tells her that "the sardines" have come in. Harpo sneaks into the basement and watches as Lefty lovingly unpacks a sardine can marked with a Maltese cross, and swipes the can from Lefty's pocket, replacing it with an unmarked one. Madame Egelichi, who has gone through eight husbands in three months in her quest for the Romanoff diamonds, is furious when Lefty produces the wrong can. When Lefty remembers seeing Harpo in the basement, she orders him to call the police and offer a $1,000 reward for his capture.At the theater, meanwhile, unemployed entertainer Faustino the Great (Chico Marx) asks Mike for a job as a mind-reader, and when Faustino's clever improvisation stops the show's backer, Mr. Lyons (Leon Belasco), from repossessing the scenery, Mike gratefully hires him. Harpo, who is secretly in love with dancer Maggie Phillips (Vera-Ellen), Mike's girl friend, gives her the sardine can, and she says she will eat them tomorrow. A policeman sees Harpo inside the theater and brings him to Madame Egelichi, who turns Harpo over to her henchmen, Alphonse (Raymond Burr) and Hannibal (Bruce Gordon) Zoto. After three days of interrogation, Harpo still refuses to talk, and when he is left alone, he calls Faustino at the theater, using the bike horn he carries in his pocket to communicate. Madame Egelichi listens on the extension as Faustino declares that there are plenty of sardines at the theater, and she goes there at once.Meanwhile, Mike has just finished telling the troupe that they do not have enough money to open when Madame Egelichi arrives and offers to finance the show. Mike cancels his plans to take Maggie out for her birthday so that he and his new backer can discuss the arrangements. In the alley outside the theater, Harpo, having escaped from Madame Egelichi's suite, finds the diamonds in the sardine can which had been set out for a cat, and puts them in his pocket. When he finds Maggie crying in her dressing room, Harpo takes her to Central Park, where he plays the harp for her and gives her the diamonds as a birthday gift.On the opening night of the show, Grunion is visited by an agent of the Romanoff family, who threatens to kill him if he does not produce the diamonds in an hour. At the theater, Lefty and the Zoto brothers spy through a window as Maggie puts on the diamond necklace, but Mike asks her not to wear it, promising to buy her an engagement ring instead. As they kiss, Maggie removes the necklace and drops it on the piano strings. The curtain goes up, and when Harpo sees Lefty and the Zoto brothers menacing Maggie, he distracts them with a piece of costume jewelry and leads them up to the roof.Meanwhile, on stage, Faustino plays the piano, and when he strikes the keys forcefully, the diamond necklace flies into the air, drawing the attention of Madame Egelichi, who is watching from the audience. Faustino pockets the diamonds, then rushes to the roof to help Harpo. Madame Egelichi shows up with a gun and demands the necklace, but Faustino gives her the fake diamonds. After tying up Lefty and the Zotos and recovering the real diamonds, Harpo encounters Grunion, who has been hiding on the roof. Harpo drops the diamonds in Grunion
Question: Who disappeared with the diamonds?
|
[
"harpo"
] |
task469-e3061eb680c744eda1efcb14ac503f75
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: 118401 LINEAR (provisional designation 1999 RE70) is an asteroid and main-belt comet (176P/LINEAR) that was discovered by the Lincoln Near-Earth Asteroid Research (LINEAR) 1-metre telescopes in Socorro, New Mexico on September 7, 1999.
Question: Who made 118401 LINEAR known?
|
[
"lincoln near-earth asteroid research"
] |
task469-53698015d936416da06c58fc3b53c42f
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Benny's Bathtub (Original title: Bennys badekar) is a 1971 Danish animated film directed by Jannik Hastrup and Flemming Quist Mller.
Question: The movie Benny's Bathtub was directed by whom?
|
[
"flemming quist møller"
] |
task469-285ca93f55dd41d9894c8dd6d555caf4
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The Parson and the Outlaw is a 1957 American western directed by Oliver Drake for Charles 'Buddy' Rogers Productions and distributed by Columbia Pictures.
Question: What is the name of the company which distributed The Parson and the Outlaw?
|
[
"columbia pictures"
] |
task469-a431dcc1a3dd4fbd90c12d80b50a07df
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Mowat-Wilson syndrome is a genetic condition characterized by a recognizable facial phenotype in addition to moderate to severe cognitive disability with severe speech impairment and variable multiple congenital anomalies. The anomalies may include Hirschsprung disease, heart defects, structural eye anomalies including microphthalmia, agenesis of the corpus callosum, and urogenital anomalies. Microcephaly, seizure disorder and constipation are common. All typical cases result from haploinsufficiency of the ZEB2 (also known as ZFHX1B or SIP-1) gene, with over 100 distinct mutations now described. Approximately 80% of patients have a nonsense or frameshift mutation detectable by sequencing, with the rest having gross deletions necessitating a dosage sensitive assay. Here we report on the results of comprehensive molecular testing for 27 patients testing positive for MWS. Twenty-one patients had a nonsense, frameshift, or splice site mutation identified by sequencing; 14 of which localized to exon 8 and 17 of which are novel. Six patients had deletions in the ZEB2 gene, including two novel partial gene deletions. This report, the first such analysis in North American patients, adds to the growing list of both novel pathogenic mutations associated with MWS, as well as other variants in the ZEB2 gene. In addition, we suggest an economical testing strategy.
Question: Which gene is responsible for the development of the Mowat-Wilson syndrome?
|
[
"zeb2",
"zfhx1b",
"sip-1"
] |
task469-65ab695bddd04bb2b6b8490aeb5a2d51
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Punarvasu) is a Nakshatra in Hindu astrology, which refers to the two brightest stars in the constellation of Gemini:
Question: What constellation does Punarvasu belong to?
|
[
"gemini"
] |
task469-92f3acb1c094491baf12d3df92065fd0
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The District of Keewatin was a territory of Canada and later an administrative district of the Northwest Territories.
Question: What was replaced District of Keewatin?
|
[
"northwest territories"
] |
task469-9b0daf82bd22431486b94c65a030935d
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: New Orleans narcotics detective Anthony Stowe (Jean-Claude Van Damme) is a heroin addict who is teetering on the edge of oblivion, and he couldn't care less.At the moment, Stowe is trying to bring down his former partner Gabriel Callahan (Stephen Rea), who has become a drug kingpin. Callahan is trying to, and slowly succeeding at, taking over the New Orleans underworld.Stowe botches a sting operation against Callahan, resulting in the death of fellow cop Maria Ronson (Rachel Grant), whose fiancee, fellow cop Van Huffel (Adam Leese), is furious at Stowe. Chief Mac Baylor (Gary Beadle) has a very blunt chat with Stowe about it. Stowe is approached by fellow cop Walter Curry (Trevor Cooper) to help his nephew beat a drug-dealing charge. Stowe instead turns him over to Baylor, who fires him. After barricading himself in the station bathroom, Walter confronts an unrepentant Stowe and condemns him for betraying his fellow officers.Later, Van Huffel berates Stowe for getting Maria killed. Stowe responds by attacking Van Huffel in front of several officers. Later, Stowe meets with his estranged wife Valerie (Selina Giles), who tells him that she's pregnant, but that he's not the father. Valerie, whose marriage with Stowe is on the rocks, has been seeing a man named Mark Rossini (Mark Dymond), the gym teacher at the school she is principle of. But he may not be the father either. Stowe brashly accuses Valerie of being impregnated by Callahan, and Valerie tells him she never wants to see him again.The only thing keeping Stowe from total collapse is his dogged pursuit of Callahan. But he drunkenly stumbles into an ambush masterminded by Callahan, and is shot in the head by Callahan's right-hand man Jimmy (Stephen Lord).Stowe undergoes emergency surgery, and ends up in a coma. Months later, he recovers to the point that he opens his eyes, and is transported to his and Valerie's house to recover properly.Seven months after getting shot, Stowe has recovered a lot, although he must learn to walk and speak again. He manages to survive an attempt on his life, by someone who appears to be a cop. He's recovered enough to try to get his job back, but that's the one thing that Chief Baylor doesn't want to give him. The coma has led to his decision to become a better man, and to right some wrongs. He reconciles with his wife, although awkwardly, and gives Walter a check for $40,000, part of his insurance money that compensated his time in a coma. Finally, he visits the grave of fellow police officer Serge (William Ash), who once saved Stowe's life but has been killed by an unknown attacker following another failed sting operation.Valerie packs up to move out of the house so she can live with Mark, but after realizing the change that Stowe has undergone, she later decides to leave Mark and come back home. Stowe is convinced by his friend Chad Mansen (Wes Robinson) not to let his wife go, and Stowe goes after her. They miss each other by a few minutes.Just after Valerie returns and meets Chad, some of Callahan's men show up. Jimmy kills Chad, and kidnaps Valerie. Stowe returns to the house, and finds Chad's body, along with Jimmy waiting for him.Van Damme promoting the film in 2007Jimmy takes Stowe to a warehouse where Callahan is waiting. Along the way, Stowe manages to overpower Jimmy and take his gun, but he finds that the odds against him are impossible- and Callahan has Valerie hostage. Van Huffel is revealed to be Callahan's mole on the police force, and the sting operation at the beginning of the film was a set-up. Walter suddenly arrives and saves Stowe. Together they kill all of Callahan's men, including Jimmy and Van Huffel, as Callahan tries to escape with Valerie to his helicopter. Just as Callahan is about to reach it, Stowe appears.In the European DVD ending, each fire a shot that kills the other. Valerie cries out
Question: Who does Jimmy take to the warehouse?
|
[
"stowe"
] |
task469-f94b0080a55649b78aed4d03344196e3
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Gaius Julius Alexander Berenicianus (Greek: , about 75 -- about 150) was a Cilician Prince and second-born son to King Gaius Julius Alexander and Queen Julia Iotapa of Cetis.
Question: Which woman was the sister of Gaius Julius Alexander Berenicianus?
|
[
"julia iotapa"
] |
task469-3a8c22c208cd4c608552dd390dac4437
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Imagine a huge bar magnet passing through Earths axis, as illustrated in Figure 24.10. This is a good representation of Earth as a magnet. Like a bar magnet, Earth has north and south magnetic poles and a magnetic field. Although a compass always points north, it doesnt point to Earths geographic north pole, which is located at 90 north latitude (see Figure 24.11). Instead, it points to Earths magnetic north pole, which is located at about 80 north latitude. Earths magnetic south pole is also located several degrees of latitude away from the geographic south pole. A compass pointer has north and south poles, and its north pole points to Earths magnetic north pole. Why does this happen if opposite poles attract? Why doesnt the compass needle point south instead? The answer may surprise you. Earths magnetic north pole is actually the south pole of magnet Earth! Its called the magnetic north pole to avoid confusion. Because its close to the geographic north pole, it would be confusing to call it the magnetic south pole. Like all magnets, Earth has a magnetic field. Earths magnetic field is called the magnetosphere. It is a huge region that extends outward from Earth for several thousand kilometers but is strongest at the poles. You can see the extent of the magnetosphere in Figure 24.12. For an animated version of the magnetosphere, watch the video at this URL: MEDIA Click image to the left or use the URL below. URL: Do you like to read science fiction? Science fiction writers are really creative. For example, an author might write about a time in the distant past when compasses pointed south instead of north. Actually, this idea isnt fictionits a fact! Earths magnetic poles have switched places repeatedly over the past hundreds of millions of years, each time reversing Earths magnetic field. This is illustrated in Figure 24.13. Scientists dont know for certain why magnetic reversals occur, but there is hard evidence showing that they have occurred. The evidence comes from rocks on the ocean floor. Look at Figure 24.14, which shows a ridge on the ocean floor. At the center of the ridge, hot magma pushes up through the crust and hardens into rock. Once the magma hardens, the alignment of magnetic domains in the rock is frozen in place forever. The newly hardened rock is then gradually pushed away from the ridge in both directions as more magma erupts and newer rock forms. Rock samples from many places on the ocean floor reveal that magnetic domains of rocks from different time periods are aligned in opposite directions. The evidence shows that Earths magnetic field reversed hundreds of times over the last 330 million years. The last reversal was less than a million years ago. What might happen if a magnetic reversal occurred in your lifetime? How might it affect you? You can learn more about Earths magnetic reversals at this URL: . The idea that Earth is a magnet is far from new. It was first proposed in 1600 by a British physician named William Gilbert. However, explaining why Earth acts like a magnet is a relatively recent discovery. It had to wait until the development of technologies such as seismographs, which detect and measure earthquake waves. Then scientists could learn about Earths inner structure (see Figure 24.15). They discovered that Earth has an inner and outer core and that the outer core consists of liquid metals, mainly iron and nickel. Scientists think that Earths magnetic field is generated by the movement of charged particles through the molten metals in the outer core. The particles move as Earth spins on its axis. The video at the URL below takes a closer look at how this occurs. MEDIA Click image to the left or use the URL below. URL: Earths magnetic field helps protect Earth and its organisms from harmful particles given off by the sun. Most of the particles are attracted to the north and south magnetic poles, where Earths magnetic field is strongest. This is also where relatively few organisms live. Another benefit of Earths magnetic field is its use for navigation. People use compasses to detect Earths magnetic north pole and tell direction. Many animals have natural "compasses" that work
Question: The idea that Earth is a magnet was first proposed in
|
[
"1600."
] |
task469-ea0ac6203d90482cb48d0fde2b832c8d
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The launch occurred at 17:00 UTC on 12 September 1967, and resulted in Kosmos 176's successful deployment into Low earth orbit.
Question: On what date did Kosmos 176 lift off?
|
[
"12 september 1967"
] |
task469-b37f9ae762da4683ba4b9085bb1a1b0c
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: It had been some time since Jack had seen the old man.Over the phone ,his mother told him,"Mr.Belser died last night ,The funeral is Wednesday."Memories flashed through his mind like an old newsreel as he sat quietly remembering his childhood days. When Jack was very young ,his father died.Mr Belser,who lived in the same neighborhood with them,spent as much time as he could to make sure Jack had a man's influence in his life.He spent a lot of time teachimg Jack he thought what was important in his following life.If Mr.Belser hadn' taught him how to weave,he wouldn't be in this business now.So he promised his mother he would attend Mr.Belser's funeral. "You'd better not drive your car.It's a long way."his mother warned him. Busy as he was,he kept his word.Though tired from the earliest flight,Jack tried his best to help.Mr.Belser's funeral was small because he had no children of his own and most of his s had passed away. The night before he had to return home,Jack and his mother stopped by to see the old house Mr.Belser once lived.Now it belonged to him.He bought the house from one of his s. The house was exactly as he remembered.Every step held memories.Every picture,every piece of furniture... Jadk stopped suddenly. The box on his desk was gone!He once asked the old man what was inside.He just smiled and said it was the most valuable thing to him,though it almost cost nothing to others.He figured that someone from the Belser family had taken it ."I will never know what was so valuable to him."Jack thought disappotntedly. Three days later returning home from work,Jack discovered a small package in his mailbox. The handwriting was difficult to read,but the return address caught his attention."Mr.Harold Belser"it read. Jack couldn't wait to open it .Inside lay the familiar small box.His heart racing,Jack unlocked the box.Inside he found a gold pocket watch with these words engraved:"Jack,Thanks for your time!Harold Belser." "The thing he valued most was my time."Jack held the watch before his chest,tears filling his eyes.
Question: What did Mr.Belser teach Jack when he aws young?
|
[
"how to weave."
] |
task469-0e4409a4bc0e42fd9a3d7e1c2a626ec8
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The film depicts a future in which human beings, known as "Oms" (a word play on the French-language word hommes, meaning men), have been brought by the giant Draags to the Draags' home planet, where they are kept as pets (with collars). The Draags are an alien race which is humanoid in shape but a hundred times larger than humans, with blue skin, fan-like earlobes and huge, protruding red eyes. The Draags also live much longer than human beings one Draag week equals a human year. Some Oms are domesticated as pets, but others run wild, and are periodically exterminated. The Draags' treatment of the Oms is ironically contrasted with their high level of technological and spiritual development.The story opens with a woman running, occasionally looking behind her as if pursued. An enormous hand descends and blocks her way. She runs back the way she came and finds her way blocked by another hand. It becomes apparent that she is being toyed with by entities that do not appreciate her fragility, and as she dies, the infant she has been carrying and attempting to protect begins to cry.The view changes to reveal the Draag children who have accidentally killed the woman; they leave quickly when an adult Draag and child approach. The child voices concern for the orphaned infant, and the two take the child to their home. Tiva (the Draag child) names the infant Terr (word play on "terrible", same spelling in French; also a homophone for the French "Terre", meaning Earth). Her father, whom the adult Terr voice-over explains is master Sinh, the Draag great Aedile, attaches a collar capable of physically dragging Terr back from mischief, and over the next several scenes, their relationships develop.Terr witnesses the parents seemingly ingesting food by inhaling it from a device. After changing Terr's costume as one would a doll's, Tiva uses makeup to give herself a more Om-like appearance. When Terr impishly trades dark pigment for light, Tiva blows some of the powder on him. Tiva uses a tiny indoor weather-maker to cause a small storm cloud to form over Terr and chase him around the dwelling. Tiva takes Terr for a walk, and then teaches him how, under certain circumstances, crystals will form on stationary objects, including standing bipeds. She also teaches him that whistling will shatter the crystals. Terr happens upon master Sinh as he and several compatriots are melding in a ritual, and it is revealed that many Draag children have Oms like Terr when they convene to watch their respective Oms interact.Tiva's education is supplied by the use of a headset that transmits knowledge directly into the brain of the user. Because she enjoys having Terr in her hand when she is having her "infos," Terr begins to acquire their knowledge.Meanwhile, at the seat of government, Draag Councilors discuss whether the regular extermination of the wild Oms is sufficient to keep their numbers at an acceptable level. It is revealed that Oms were first found on a planet that retained some evidence of structured life, but the images seem to reveal that Earth was in a post-apocalyptic state at the time.Terr decides to escape, and to take the headset with him. He does not get very far before Tiva realizes he is missing, and her mother tells her to use her bracelet to bring him back. Terr finds himself suddenly being dragged backward by the collar. Only the headset becoming entangled in plants allows a wild female Om to come to his rescue before he is choked by the collar or dragged all the way back.When Terr explains that the headset contains the knowledge of the Draags but he doesn't know where to go with it, his unnamed rescuer takes him to her tribe, who live in a tree in a walled park. When it is demonstrated that Terr can read Draag script, the leader (known only as "Mighty One") is willing to accept Terr into the tribe, but the Wizard is not, and demands a trial by combat to the death. Terr and the Wizard's champion have child
Question: What color are the Draags?
|
[
"blue"
] |
task469-745500cfade4446dbdf1367bf6e37910
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Bob and Doug McKenzie (Rick Moranis and Dave Thomas) are two dim-witted and unemployed "hosers" living in Toronto, Ontario who find themselves in a bind when they squander their father's beer money and then run out of beer. The brothers place a live mouse in a beer bottle in an attempt to blackmail the local beer store into giving them free Elsinore beer, but are told to take up the matter at the Elsinore brewery instead. After presenting the mouse to management at the brewery, the brothers are given jobs on the bottling line inspecting the bottles for mice. They take this opportunity to drink lots of free beer off the line; later, they present their parents with a van full of free Elsinore beer products as part of their payment with their new jobs.Meanwhile, the evil owner of the brewery, Brewmeister "B.M." Smith (Max von Sydow), is perfecting a secret plan to take over the world by placing a mind-control drug in Elsinore beer which, while rendering the consumer docile, also makes him or her attack others when stimulated by certain musical tones. Smith tests this adulterated beer on patients of the conveniently located Royal Canadian Institute for the Mentally Insane, which is connected by underground tunnels to the brewery. The effects of the tainted beer are demonstrated in an extended sequence during which the mental patients don armored Star Wars-style hockey garb and, after consuming the beer, respond to synthesizer music by variously playing hockey, skating together in sync, and brawling on the ice.It seems the former brewery owner John Elsinore has recently died under mysterious circumstances and his daughter, Pam (Lynne Griffin), having recently turned 21, has been given full control of the Elsinore brewery. Pam's incompetent uncle Claude (Paul Dooley), in the interim, had married her widowed mother and is reluctant to give up his recently-gained control of the brewery. The reason for this is further revealed to be that the bumbling Claude is collaborating with Brewmeister Smith, for whom he is a buffoonish toady, providing a cover for the Brewmeister's nefarious plans. Bob and Doug blunder into the midst of these plans when they rescue Pam from a malfunctioning security gate and both become fast friends with her.While exploring the massive brewery, Bob and Doug find a shuttered cafeteria containing an old Galactic Border Patrol video game that supernaturally reveals that Brewmeister Smith murdered John Elsinore and that Uncle Claude was deeply involved. Additionally, while poking around the brewery, Bob and Doug meet a one time hockey great, Jean "Rosie" LeRose (Angus MacInnes), whom Bob recognizes from the hockey card he has back home at his parents' house. Having suffered a career-ending nervous breakdown and fallen under Smith's control, Rosie gets locked up at the insane asylum but is determined to fight against the Brewmeister's plot for world domination.Eventually, Bob and Doug wander into Brewmeister's operations room while he is away, and Doug takes a record disk of John Elsinore's murder, believing that it is a New Wave bootleg record. Immediately afterward, Brewmeister and Claude shoot the brothers with tranquilizers. They then dress up in the brothers clothes where they are shown on security camera shooting tranquilizer darts at Pam and a friendly associate, named Henry Green, and put their unconcious bodies in kegs.When Bob and Doug wake up, they are back in their van, convinced that their suspicious discoveries were all just dreams, and they are instructed by Claude to deliver two kegs of beer (actually containing an unconscious Pam and her father's friend, Henry Green) to a party at the bottom of a big hill. However, the brakes have been modified to only allow two stops before giving out altogether.Nevertheless, as Bob and Doug drive, they soon get distracted and decide to stop off at their house to feed their dog. They also leave behind the incriminating record disk of Brewmeister and Claude's actions at their house. Having wasted one stop prior, they find themselves unable to stop the now-speeding vehicle and eventually wind up jumping off of the Toronto pier into Lake Ontario. Rosie arrives and tries to rescue Pam who
Question: What brand of free beer Bob and Doug McKenzie want?
|
[
"elsinore beer"
] |
task469-64aac0eae84e4ef4964cb0dc4d62ee64
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Sigurd Wallin was the son of the Swedish artist David Wallin (1876-1957) and his wife Elin Wallin (1884-1969), born Lundberg, Stockholm.
Question: What is Sigurd Wallin's father's name?
|
[
"david wallin"
] |
task469-3db46f1a924142f8bdcc5e9c1fd31f84
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: A personal journey into the heart of the Killing FieldsOne of the most harrowing and compelling personal documentaries of our time, ENEMIES OF THE PEOPLE exposes for the first time the truth about the Killing Fields and the Khmer Rouge who were behind Cambodias horrific genocide. More than simply an inquiry into Cambodias experience, however, ENEMIES OF THE PEOPLE is a profound meditation on the nature of good and evil, shedding light on the capacity of some people to do terrible things and for others to forgive them.Winner of a dozen top documentary festival awards, including a Special Jury Prize at Sundance and the Grand Jury Award at the Full Frame Documentary Festival, this is a riveting film that takes audiences as close to witnessing evil as they are ever likely to get. It is also a personal journey into the heart of darkness by journalist/filmmaker Thet Sambath, whose family was wiped out in the Killing Fields, but whose patience and discipline elicits unprecedented on-camera confessions from perpetrators at all levels of the Khmer Rouge hierarchy. This is investigative journalism of the highest order.In 1974, Thet Sambaths father became one of the nearly two million people who were murdered by the Khmer Rouge when he refused to give them his buffalo. Sambaths mother was forced to marry a Khmer Rouge militiaman and died in childbirth in 1976, while his eldest brother disappeared in 1977. Sambath himself escaped Cambodia at age 10 when the Khmer Rouge fell in 1979.Fast forward to 1998, and Sambath, now a journalist, got to know the children of some senior Khmer Rouge cadre and gradually earned their trust. Then, for a decade, he spent weekends visiting the home of the most senior surviving leader, Nuon Chea, aka Brother Number Two under Pol Pot. But he never used to say anything different from what he told Western journalists, says Sambath, I was low-ranking, I knew nothing, I am not a killer. Then one day he said to me Sambath, I trust you, you are the person I would like to tell my story to. Ask me what you want to know. For the next five years he told me the truth, as he saw it, including all the details of killing.Sambath also won the confidence of lower-level Khmer Rouge soldiers, now ordinary fathers and grandfathers, who demonstrated to him how they slit peoples throats. For these murderers, it was the first time they admitted what they had done. He taped their interactions and discussions about the killings, and together with British documentarian Rob Lemkin they created this landmark film.For Sambath, it has been an ongoing, lifelong personal journey to discover what was behind such horror; he neglected both his family and his own happiness in the search for truth with hope of reconciliation. ENEMIES OF THE PEOPLE is at once a cinematically beautiful, chillingly insightful, and deeply personal piece of documentary filmmaking.
Question: What regime was Nuon Chea unwilling to talk about in regards to his political career?
|
[
"khmer rouge"
] |
task469-ce77e36fef5a4012b9466d6c5c4b6ff2
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Simon Miller (Loren Dean) outwardly appears to be a geologist who must frequently take business trips, which has strained the relationship with his family, including his wife Meredith (Robyn Lively) and teenage children Sarah (Skyler Day) and Kevin (Drew Koles). When Simon suddenly goes missing, his family searches his office and discovers several passports, each with different aliases. They soon learn that Simon was in fact a spy who kept his true career secret from them. Simon mysteriously calls home and warns his family not to tell anyone about his disappearances, then abruptly hangs up. His family begins a search for Simon, which takes them to locations around the world. Sarah, an honor student, uses her foreign language skills to help, and Kevin uses his knowledge of technology.[1] They receive assistance from Amanda (Christine Baranski), another covert operative who initially appears to be a friend, but appears to have her own motives.[2]
Question: What do they find in Simon's office?
|
[
"several passports"
] |
task469-17a6342b9312434c847a15d562083c69
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: STS-115 launched from Pad 39-B at the Kennedy Space Center on 9 September 2006 at 11:14:55 EDT (15:14:55 UTC).
Question: What was the date STS-115 was launched?
|
[
"9 september 2006"
] |
task469-45522d912f1441a780f5601d1b79ffbd
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The film opens with narration over a silhouette of Hill House at night. The narrator, Dr. John Markway (Richard Johnson) tells us, "An evil old house, the kind some people call haunted is like an undiscovered country waiting to be explored. Hill House had stood for 90 years and might stand for 90 more. Silence lay steadily against the wood and stone of Hill House. Whatever walked there walked alone." Title and credits follow, then narration continues, "Scandal, murder, insanity, suicide: The history of Hill House was ideal. It had everything I wanted..." The house was built in New England by a man named Hugh Crain for his wife and young daughter. A horse and carriage accident took the life of the first Mrs. Crain (an uncredited Pamela Buckley) before she even saw the house. Hugh Crain (an uncredited Howard Lang) and young daughter, Abigail (an uncredited Janet Mansell) said a few words over the body, but Hugh was left an embittered man. Crain married again, and the second Mrs. Crain (an uncredited Freda Knorr) also died, falling down the main staircase. Hugh Crain left Abigail with a nurse (an uncredited Susan Richards) and went to England where he died in a drowning accident. Abigail kept the same nursery room her entire life. By the time she was eighty (an uncredited Amy Dalby) she was a bedridden invalid. Her nurse-companion (an uncredited Rosemary Dorken) was a local girl and, it is with this young companion the evil reputation of Hill House really begins. The old lady died while calling for help. The companion was trysting on the verandah with a farm hand. The companion inherited Hill House and occupied it for many years, but eventually hanged herself. The house then passed to a distant relative, named Mrs. Sanderson (Fay Compton).Markway visits Mrs. Sanderson where he convinces her to let him use the house for psychic research. He explains, "I shall occupy the house with a group of carefully selected assistants...I must have specially qualified help to take notes and document any evidence of the supernatural I may find." Eldridge Harper (Ronald Adam), Mrs. Sanderson's lawyer, voices his concern about publicity seekers and the propriety of having women in the house. Harper suggests to Mrs. Sanderson that her nephew, Luke, joins the doctor at Hill House, as he expects to inherit the property. Mrs. Sanderson asks point blank, "Exactly what do you and your assistants expect to find at Hill House?" Markway replies, "Maybe only a few loose floorboards, and maybe, I only say maybe, the key to another world."Dr. Markway, taking a leave of absence from his university professorship, finalizes his list of assistants. Only two end up accepting, Eleanor Lance and Theodora (no last name).Eleanor Lance (Julie Harris) is living with her sister. She is nearly broke and weary after looking after her invalid mother non-stop for eleven years. Mother is now dead, and she fights with her sister over just about everything. She begs to use the car, which is after all, half hers. Her brother-in-law, Bud Fredericks (an uncredited Paul Maxwell) tries to act as mediator between Eleanor and his wife, Carrie (Diane Clare). He is sympathetic to Eleanor's plight, but their daughter, Dora (an uncredited Verina Greenlaw) takes her cues from her mother, and taunts her Aunt Eleanor. On the vacation plan, Bud sides with Eleanor, "I think you should have a vacation, Nell." Carrie objects, but Eleanor is not to be deterred and she shows her family how she reacts when pushed to her breaking point. She is normally quiet and meek, but when pushed is loud and assertive.Nell decides to take the car and confronts the garage attendant (an uncredited Claude Jones) for the keys. She departs Boston along U.S. 50 and Route 238 to Hill House. We hear Nell thinking and she reveals she will never return to live with her sister. In fact, most of what we learn of Eleanor is hearing her thoughts.Eleanor
Question: What is the ghost's name?
|
[
"hugh crain",
"the ghost's name is hugh crain",
"nell"
] |
task469-a5065df16ae34a8b88d8ed600129b0ef
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Since the early 2000s, the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infections among the community of people lacking known healthcare risk factors has increased. This MRSA infection is referred to as community-associated MRSA (CA-MRSA) infection and is distinct from hospital-associated MRSA (HA-MRSA) infection, which occurs among people with known healthcare risk factors. Understanding the epidemiology of CA-MRSA infections is critical; however, this has not been investigated in detail in Japan. Our objective was to investigate the incidence of CA-MRSA infections in a regional hospital. We investigated CA-MRSA isolates and infections in a rural regional hospital by reviewing medical records of one year. Infections were classified as CA-MRSA if no established risk factors were identified. During 2008, 31 Staphylococcus aureus (S. aureus) isolates were detected in 29 unique patients, with 1 methicillin-sensitive S. aureus (MSSA) isolates obtained from 19 patients (66%) and MRSA obtained from 10 patients (34%). In the 10 patients with MRSA, the number of HA-MRSA and CA-MRSA cases were nine (32% of patients with S. aureus isolates) and one (3%), respectively. The patient with CA-MRSA was diagnosed with cellulitis due to CA-MRSA. All nine patients with HA-MRSA exhibited colonization. We observed a CA-MRSA case in a regional hospital in Japan, suggesting that incidence trends of CA-MRSA should be considered in future research and treatment.
Question: What is MRSA?
|
[
"mrsa",
"methicillin-resistant s. aureus"
] |
task469-d24f22d5c6bb4969bc7e4e5a14e7fc61
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Diamond-Blackfan anemia (DBA) features hypoplastic anemia and congenital malformations, largely caused by mutations in various ribosomal proteins. The aim of this study was to characterize the spectrum of genetic lesions causing DBA and identify genotypes that correlate with phenotypes of clinical significance. Seventy-four patients with DBA from across Canada were included. Nucleotide-level mutations or large deletions were identified in 10 ribosomal genes in 45 cases. The RPS19 mutation group was associated with higher requirement for chronic treatment for anemia than other DBA groups. Patients with RPS19 mutations, however, were more likely to maintain long-term corticosteroid response without requirement for further chronic transfusions. Conversely, patients with RPL11 mutations were less likely to need chronic treatment. Birth defects, including cardiac, skeletal, hand, cleft lip or palate and genitourinary malformations, also varied among the various genetic groups. Patients with RPS19 mutations had the fewest number of defects, while patients with RPL5 had the greatest number of birth defects. This is the first study to show differences between DBA genetic groups with regards to treatment. Previously unreported differences in the rate and types of birth defects were also identified. These data allow better patient counseling, a more personalized monitoring plan, and may also suggest differential functions of DBA genes on ribosome and extra-ribosomal functions.
Question: In which syndrome is the RPS19 gene most frequently mutated?
|
[
"dba",
"diamond-blackfan anemia"
] |
task469-1b3827cb02c845dd870ee1fc2d4ad4c8
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The study of rock strata is called stratigraphy. The laws of stratigraphy can help scientists understand Earths past. The laws of stratigraphy are usually credited to a geologist from Denmark named Nicolas Steno. He lived in the 1600s. The laws are illustrated in Figure 11.6. Refer to the figure as you read about the laws below. Superposition refers to the position of rock layers and their relative ages. Relative age means age in comparison with other rocks, either younger or older. The relative ages of rocks are important for understanding Earths history. New rock layers are always deposited on top of existing rock layers. Therefore, deeper layers must be older than layers closer to the surface. This is the law of superposition. You can see an example in Figure 11.7. Rock layers extend laterally, or out to the sides. They may cover very broad areas, especially if they formed at the bottom of ancient seas. Erosion may have worn away some of the rock, but layers on either side of eroded areas will still match up. Look at the Grand Canyon in Figure 11.8. Its a good example of lateral continuity. You can clearly see the same rock layers on opposite sides of the canyon. The matching rock layers were deposited at the same time, so they are the same age. Sediments were deposited in ancient seas in horizontal, or flat, layers. If sedimentary rock layers are tilted, they must have moved after they were deposited. Rock layers may have another rock cutting across them, like the igneous rock in Figure 11.9. Which rock is older? To determine this, we use the law of cross-cutting relationships. The cut rock layers are older than the rock that cuts across them. Geologists can learn a lot about Earths history by studying sedimentary rock layers. But in some places, theres a gap in time when no rock layers are present. A gap in the sequence of rock layers is called an unconformity. Look at the rock layers in Figure 11.10. They show a feature called Huttons unconformity. The unconformity was discovered by James Hutton in the 1700s. Hutton saw that the lower rock layers are very old. The upper layers are much younger. There are no layers in between the ancient and recent layers. Hutton thought that the intermediate rock layers eroded away before the more recent rock layers were deposited. Huttons discovery was a very important event in geology! Hutton determined that the rocks were deposited over time. Some were eroded away. Hutton knew that deposition and erosion are very slow. He realized that for both to occur would take an extremely long time. This made him realize that Earth must be much older than people thought. This was a really big discovery! It meant there was enough time for life to evolve gradually. When rock layers are in the same place, its easy to give them relative ages. But what if rock layers are far apart? What if they are on different continents? What evidence is used to match rock layers in different places? Some rock layers extend over a very wide area. They may be found on more than one continent or in more than one country. For example, the famous White Cliffs of Dover are on the coast of southeastern England. These distinctive rocks are matched by similar white cliffs in France, Belgium, Holland, Germany, and Denmark (see Figure 11.11). It is important that this chalk layer goes across the English Channel. The rock is so soft that the Channel Tunnel connecting England and France was carved into it! Like index fossils, key beds are used to match rock layers. A key bed is a thin layer of rock. The rock must be unique and widespread. For example, a key bed from around the time that the dinosaurs went extinct is very important. A thin layer of clay was deposited over much of Earths surface. The clay has large amount of the element iridium. Iridium is rare on Earth but common in asteroids. This unusual clay layer has been used to match rock up layers all over the world. It also led to the hypothesis that a giant asteroid struck Earth and caused the
Question: whether a rock is older or younger than other rocks
|
[
"relative age"
] |
task469-679a5e3f0bd6441587a22c00486fce7f
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Phosphorylation of cytoplasmic polyadenylation element binding protein (CPEB) regulates protein synthesis in hippocampal dendrites. CPEB binds the 3' untranslated region (UTR) of cytoplasmic mRNAs and, when phosphorylated, initiates mRNA polyadenylation and translation. We report that, of the protein kinases activated in the hippocampus during synaptic plasticity, calcium/calmodulin-dependent protein kinase II (CaMKII) robustly phosphorylated the regulatory site (threonine 171) in CPEB in vitro. In postsynaptic density fractions or hippocampal neurons, CPEB phosphorylation increased when CaMKII was activated. These increases in CPEB phosphorylation were attenuated by a specific peptide inhibitor of CaMKII and by the general CaM-kinase inhibitor KN-93. Inhibitors of protein phosphatase 1 increased basal CPEB phosphorylation in neurons; this was also attenuated by a CaM-kinase inhibitor. To determine whether CaM-kinase activity regulates CPEB-dependent mRNA translation, hippocampal neurons were transfected with luciferase fused to a 3' UTR containing CPE-binding elements. Depolarization of neurons stimulated synthesis of luciferase; this was abrogated by inhibitors of protein synthesis, mRNA polyadenylation, and CaMKII. These results demonstrate that CPEB phosphorylation and translation are regulated by CaMKII activity and provide a possible mechanism for how dendritic protein synthesis in the hippocampus may be stimulated during synaptic plasticity.
Question: Which kinase is inhibited by the small molecule KN-93?
|
[
"cam kinase ii",
"calcium/calmodulin-dependent protein kinase ii",
"camk2",
"the calcium/calmodulin-dependent protein kinase-ii"
] |
task469-a56c51f08579497b9b3e08044901fc60
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: In the opening scene, private detective Sam Grunion (Groucho Marx) explains to the viewers that he has been searching for the extremely valuable Royal Romanoff diamonds for eleven years, and his investigation leads him to a troupe of struggling performers, led by Mike Johnson (Paul Valentine), who are trying to put on a musical revue called 'Love Happy'.Grunion notes that the impoverished young dancers would starve were it not for the sweet, silent Harpo (Harpo Marx), at Herbert & Herbert, a gourmet food shop that also trafficks in stolen diamonds. Harpo kindly helps ladies with their shopping bags, all the while pilfering their groceries and stuffing them in the pockets of his long trench coat. When the elegant Madame Egelichi (Ilona Massey) arrives, store manager Lefty Throckmorton (Melville Cooper) tells her that "the sardines" have come in. Harpo sneaks into the basement and watches as Lefty lovingly unpacks a sardine can marked with a Maltese cross, and swipes the can from Lefty's pocket, replacing it with an unmarked one. Madame Egelichi, who has gone through eight husbands in three months in her quest for the Romanoff diamonds, is furious when Lefty produces the wrong can. When Lefty remembers seeing Harpo in the basement, she orders him to call the police and offer a $1,000 reward for his capture.At the theater, meanwhile, unemployed entertainer Faustino the Great (Chico Marx) asks Mike for a job as a mind-reader, and when Faustino's clever improvisation stops the show's backer, Mr. Lyons (Leon Belasco), from repossessing the scenery, Mike gratefully hires him. Harpo, who is secretly in love with dancer Maggie Phillips (Vera-Ellen), Mike's girl friend, gives her the sardine can, and she says she will eat them tomorrow. A policeman sees Harpo inside the theater and brings him to Madame Egelichi, who turns Harpo over to her henchmen, Alphonse (Raymond Burr) and Hannibal (Bruce Gordon) Zoto. After three days of interrogation, Harpo still refuses to talk, and when he is left alone, he calls Faustino at the theater, using the bike horn he carries in his pocket to communicate. Madame Egelichi listens on the extension as Faustino declares that there are plenty of sardines at the theater, and she goes there at once.Meanwhile, Mike has just finished telling the troupe that they do not have enough money to open when Madame Egelichi arrives and offers to finance the show. Mike cancels his plans to take Maggie out for her birthday so that he and his new backer can discuss the arrangements. In the alley outside the theater, Harpo, having escaped from Madame Egelichi's suite, finds the diamonds in the sardine can which had been set out for a cat, and puts them in his pocket. When he finds Maggie crying in her dressing room, Harpo takes her to Central Park, where he plays the harp for her and gives her the diamonds as a birthday gift.On the opening night of the show, Grunion is visited by an agent of the Romanoff family, who threatens to kill him if he does not produce the diamonds in an hour. At the theater, Lefty and the Zoto brothers spy through a window as Maggie puts on the diamond necklace, but Mike asks her not to wear it, promising to buy her an engagement ring instead. As they kiss, Maggie removes the necklace and drops it on the piano strings. The curtain goes up, and when Harpo sees Lefty and the Zoto brothers menacing Maggie, he distracts them with a piece of costume jewelry and leads them up to the roof.Meanwhile, on stage, Faustino plays the piano, and when he strikes the keys forcefully, the diamond necklace flies into the air, drawing the attention of Madame Egelichi, who is watching from the audience. Faustino pockets the diamonds, then rushes to the roof to help Harpo. Madame Egelichi shows up with a gun and demands the necklace, but Faustino gives her the fake diamonds. After tying up Lefty and the Zotos and recovering the real diamonds, Harpo encounters Grunion, who has been hiding on the roof. Harpo drops the diamonds in Grunion
Question: Who shows up and offers to finance the show?
|
[
"madame egelichi"
] |
task469-ca0fde07d75b49fcbd0521f6c6afd328
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Khivi (1506--1582) also referred to as Mata Khivi or Bibi Khivi was the wife of Guru Angad Dev, second Sikh guru.
Question: What is Khivi's spouse's name?
|
[
"guru angad dev"
] |
task469-fe832057317f449681ec633d65f66bc6
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The completeness of meningioma resection depends on the resection of dura mater invaded by the tumor. The pathological changes of the dura around the tumor can be interpreted by evaluating the dural tail sign (DTS) on MRI studies. The goal of this study was to clarify the pathological characteristics of the DTSs, propose a classification based on the histopathological and radiological correlation, and identify the invasive range of tumor cells in different types of DTS. The authors retrospectively reviewed 179 patients with convexity meningiomas who underwent Simpson Grade I resection. All patients underwent an enhanced MRI examination preoperatively. The convexity meningiomas were dichotomized into various subtypes in accordance with the 2007 WHO classification of tumors of the CNS, and the DTS was identified based on the Goldsher criteria. The range of resection of the involved dura was 3 cm from the base of the tumor, which corresponded with the length of DTS on MRI studies. Histopathological examination of dura at 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 cm from the base of the tumor was conducted, and the findings were correlated with the preoperative MRI appearance of the DTS. A total of 154 (86%) of 179 convexity meningiomas were classified into WHO Grade I subtype, including transitional (44 [28.6%] of 154), meningothelial (36 [23.4%] of 154), fibrous (23 [14.9%] of 154), psammomatous (22 [14.3%] of 154), secretory (10 [6.5%] of 154), and angiomatous (19 [12.3%] of 154). The other 25 (14%) were non-Grade I (WHO) tumors, including atypical (12 [48%] of 25), anaplastic (5 [20%] of 25), and papillary (8 [32%] of 25). The DTS was classified into 5 types: smooth (16 [8.9%] of 179), nodular (36 [20.1%] of 179), mixed (57 [31.8%] of 179), symmetrical multipolar (15 [8.4%] of 179), and asymmetrical multipolar (55 [30.7%] of 179). There was a significant difference in distribution of DTS type between Grade I and non-Grade I tumors (p = 0.004), whereas the difference was not significant among Grade I tumors (0.841) or among non-Grade I tumors (p = 0.818). All smooth-type DTSs were encountered in Grade I tumors, and the mixed DTS (52 [33.8%] of 154) was the most common type in these tumors. Nodular-type DTS was more commonly seen in non-Grade I tumors (12 [48%] of 25). Tumor invasion was found in 88.3% (158 of 179) of convexity meningiomas, of which the range of invasion in 82.3% (130 of 158) was within 2 cm and that in 94.9% (150 of 158) was within 2.5 cm. The incidence of invasion and the range invaded by tumor cells varied in different types of DTS, and differences were statistically significant (p < 0.001). Nodular-type DTS on MRI studies might be associated with non-Grade I tumors. The range of dural resection for convexity meningiomas should be 2.5 cm from the tumor base, and if this extent of resection is not feasible, the type of DTS should be considered. However, for skull base meningiomas, in which mostly Simpson Grade II resection is achieved, the use of this classification should be further validated. The classification of DTS enables the surgeon to predict preoperatively and then to achieve the optimal range of dural resection that might significantly reduce the recurrence rate of meningiomas.
Question: Simpson grading is used to describe resection of which brain tumor?
|
[
"meningioma"
] |
task469-44bd9645d044427882f4fcaf47328429
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Josef Steudel (21 July 1917 -- 4 May 2004) was a highly decorated Hauptmann in the Luftwaffe during World War II, and a recipient of the Knight's Cross of the Iron Cross.
Question: In what war did Josef Steudel fight?
|
[
"world war ii"
] |
task469-d5d9aa999eca41518dcd89b4ff55c4a0
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Leptoxis ampla is a vulnerable species according to the IUCN Red list.
Question: What is an ecological status of Leptoxis ampla?
|
[
"vulnerable"
] |
task469-adcba38deaba4114b604e3c6dd2014d9
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The Dolphins' eighth game was an AFC duel with the Ravens. The Dolphins trailed early after QB Joe Flacco completed a 32-yard TD pass to RB Willis McGahee. They replied with RB Ronnie Brown getting a 12-yard TD run. The Ravens got the lead back after kicker Billy Cundiff made a 26 and a 39-yard field goal. The Dolphins narrowed the lead with kicker Dan Carpenter nailing a 19-yard field goal. The Dolphins fell further behind after Flacco found WR Derrick Mason on a 12-yard TD pass. This was followed in the 4th quarter by Cundiff hitting a 20 and a 24-yard field goal.
Question: Who kicked the longest field goal?
|
[
"billy cundiff"
] |
task469-f2bd6d9f77ae453da77cf5fe008dfa14
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Petr Prajsler (born September 21, 1965 in Hradec Kralove, Czechoslovakia) is a retired Czech ice hockey defenceman who played in the National Hockey League for the Los Angeles Kings between 1987 to 1990 and the Boston Bruins in 1991.
Question: What team does Petr Prajsler belong to?
|
[
"los angeles kings"
] |
task469-23c0a491d78d4d3e8df05cab3bd99442
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Aud Alvr (27 November 1921 -- 11 June 2000) was a Norwegian politician for the Liberal Party.
Question: What party does Aud Alvr serve?
|
[
"liberal party"
] |
task469-2afa55d87384480f97896366b757ca03
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Brian Cohen is born in a stable next door to the one in which Jesus is born, which initially confuses the three wise men who come to praise the future King of the Jews. Brian grows up an idealistic young man who resents the continuing Roman occupation of Judea. While attending Jesus' Sermon on the Mount, Brian becomes infatuated with an attractive young rebel, Judith. His desire for her and hatred for the Romans lead him to join the "People's Front of Judea", one of many fractious and bickering independence movements, who spend more time fighting each other than the Romans. After several misadventures, and escaping from Pontius Pilate, Brian winds up in a line-up of would-be mystics and prophets who harangue the passing crowd in a plaza. Forced to come up with something plausible in order to blend in and keep the guards off his back, Brian repeats some of what he had heard Jesus say, and quickly attracts a small but intrigued audience. Once the guards have left, Brian tries to put the episode behind him, but he has unintentionally inspired a movement. He grows frantic when he finds that some people have started to follow him around, with even the slightest unusual occurrence being hailed as a miracle. Each of their responses ever growing in fervor and intensity making it harder and harder for him to get away from them. Yet because of the mob's excitement, they end up leaving Brian alone. After which he sees Judith is one who didn't leave, and they then spend the night together. In the morning, Brian, completely naked, opens the curtains to discover an enormous crowd outside his mother's house who proclaim him to be the Messiah. Brian's mother protests, "He's not the Messiah, he's a very naughty boy."; and, "There's no Messiah in here. There's a mess all right, but no Messiah." Yet all of her attempts at dispersing the crowd are rebuffed. Furthermore, once Brian addresses them, he also finds that he is unable to change their minds. His followers are completely committed to their beliefs in and of Brian's divinity. They immediately seize upon everything he says and does as points of doctrine. The hapless Brian finds no solace as people have even mobbed his mother's house. They fling their afflicted bodies at him demanding miracle cures and divine secrets. After sneaking out the back, Brian is then finally captured and scheduled to be crucified. Meanwhile, a huge crowd has assembled outside the palace. Pilate (together with the visiting Biggus Dickus) tries to quell the feeling of revolution by granting them the choice of one person to be pardoned. The crowd, however, shouts out names containing the letter "r", mocking Pilate's rhotacistic speech impediment. Eventually, Judith appears in the crowd and calls for the release of Brian, which the crowd echoes since the name also contains an "r". Pilate agrees to "welease Bwian". His order is eventually relayed to the guards, but in a scene that parodies the climax of the film Spartacus, various crucified people all claim to be "Brian of Nazareth" and the wrong man is released. Various other opportunities for a reprieve for Brian are denied as, one by one, his "allies" (including Judith and his mother) step forward to explain why they are leaving the "noble freedom fighter" hanging in the hot sun. Hope is renewed when a crack suicide squad from the "Judean People's Front" (not to be confused with the People's Front of Judea) come charging towards the Romans, but rather than fighting to release Brian or the other prisoners, they commit mass suicide as a political protest. Condemned to a long and painful death, Brian finds his spirits lifted by his fellow sufferers, who break into song with "Always Look on the Bright Side of Life."[6]
Question: Who does Brian's birth initially confuse?
|
[
"the three wise men"
] |
task469-edccd91e9c594533b25426ca4de7439e
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: What does population growth mean? You can probably guess that it means the number of individuals in a population is increasing. The population growth rate tells you how quickly a population is increasing or decreasing. What determines the population growth rate for a particular population? Population growth rate depends on birth rates and death rates, as well as migration. First, we will consider the effects of birth and death rates. You can predict the growth rate by using this simple equation: growth rate = birth rate death rate. If the birth rate is larger than the death rate, then the population grows. If the death rate is larger than the birth rate, what will happen to the population? The population size will decrease. If the birth and death rates are equal, then the population size will not change. Factors that affect population growth are: 1. 2. 3. 4. 5. 6. Age of organisms at first reproduction. How often an organism reproduces. The number of offspring of an organism. The presence or absence of parental care. How long an organism is able to reproduce. The death rate of offspring. For an ecosystem to be stable, populations in that system must be healthy, and that usually means reproducing as much as their environment allows. Do organisms reproduce yearly or every few years? Do organisms reproduce for much of their life, or just part of their life? Do organisms produce many offspring at once, or just a few, or even just one? Do many newborn organisms die, or do the majority survive? All these factors play a role in the growth of a population. Organisms can use different strategies to increase their reproduction rate. Altricial organisms are helpless at birth, and their parents give them a lot of care. This care is often seen in bird species. ( Figure 1.1). Altricial birds are usually born blind and without feathers. Compared to precocial organisms, altricial organisms have a longer period of development before they reach maturity. Precocial organisms, such as the geese shown below, can take care of themselves at birth and do not require help from their parents ( Figure 1.1). In order to reproduce as much as possible, altricial and precocial organisms must use very different strategies. (left) A hummingbird nest with young il- lustrates an altricial reproductive strategy, with a few small eggs, helpless young, and intensive parental care. (right) The Canada goose shows a precocial repro- ductive strategy. It lays a large number of large eggs, producing well-developed young. Migration is the movement of individual organisms into, or out of, a population. Migration affects population growth rate. There are two types of migration: 1. Immigration is the movement of individuals into a population from other areas. This increases the population size and growth rate. 2. Emigration is the movement of individuals out of a population. This decreases the population size and growth rate. The earlier growth rate equation can be modified to account for migration: growth rate = (birth rate + immigration rate) (death rate + emigration rate). One type of migration that you are probably familiar with is the migration of birds. Maybe you have heard that birds fly south for the winter. In the fall, birds fly thousands of miles to the south where it is warmer. In the spring, they return to their homes. ( Figure 1.2). Monarch butterflies also migrate from Mexico to the northern U.S. in the summer and back to Mexico in the winter. These types of migrations move entire populations from one location to another. A flock of barnacle geese fly in formation during the autumn migration. Population growth can be described with two models, based on the size of the population and necessary resources. These two types of growth are known as exponential growth and logistic growth. If a population is given unlimited amounts of resources, such as food and water, land if needed, moisture, oxygen, and other environmental factors, it will grow exponentially. Exponential growth occurs as a population grows larger, dramatically increasing the growth rate. This is shown as a "J-shaped" curve below
Question: if the death rate is larger than the birth rate, what will happen to the population?
|
[
"the population size will decrease."
] |
task469-7027d093845d4dc78c4ee7e4fb8a33e4
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Dorothee Bar (nee Mantel, born 19 April 1978 in Bamberg, Bavaria) is a German politician that has served as the National Deputy Secretary General of the Christian Social Union of Bavaria since 2009.
Question: From which political party is Dorothee Bar?
|
[
"christian social union of bavaria"
] |
task469-ef52a8d8dca54785b276864539463cb0
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Hamzeh Al Aitoni (Arabic: ) (born 16 January 1986 in Damascus, Syria) is a Syrian footballer who plays as a defender for Al-Nidal, which competes in the Syrian Premier League and is a member of the Syria national football team.
Question: In what capacity did Hamzeh Al Aitoni play football?
|
[
"defender"
] |
task469-d3dd52775e684e809fc559f13d6b13c5
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: Father's day Sunset Live Music Dinner Cruise Sunday, June 16th, 2013 6:30pm-8:30pm Join us abroad the 95' Dana Pride for our special Father's Day Dinner Cruise. Enjoy a unique evening of fun on the water, complete with live music by Mike O' Brien and a delicious barbecue dinner. Adult--$ 59 Kids (3-12)--$29 Two and under are Free LOCATION: Dana Point Harbor BOOK ONLINE OR CALL: 949-496-5794 Rancho Days Fiesta July 13, 2013 Celebration the history of Saddleback Valley, there will be children's activities including free crafts projects. Help make and taste homemade ice cream and butter, warm bread from the oven. Dip water and grind corn while learning about the early days of Orange County. Admission is $ 3 for children 3 to 12 years old and $4 for adults. LOCATION: Heritage Hill Historical Park INFORMATION: 949-923-2230 Annual Silverado Counter Fair and Art Festival October 5-6, 2013 The 42thAnnual Silverado Country Fair explores the wonders of the area's Old West rustic culture, great live music tasty food, handmade arts, crafts and family games under the oak-trees below Orange Country's famous Saddleback Mountain. Daytime adult admission: $4/ Kids under 12: only $2 Saturday Night Music Fest : $ 5 for everyone LOCATION: Silverado Community Center INFORMATION: 714-997-3968 Starr Ranch Sanctuary October 20-21, 2013 Audubon California's Starr Ranch Sanctuary invites you to our fall classes for adults. Join our wildlife biologist for two peaceful days at beautiful 4,000 acre Starr Ranch in southeast Orange County and experience nature hands-on as a wildlife researcher. Cost: $ 95 for those not camping (including dinner) $100 for those camping (dinner and breakfast provided) LOCATION: Starr Ranch Sanctuary RESERVATIONS OR INFORMATION: 949-858-0309
Question: Which event is the most suitable for one who wants to enjoy dinner in a boat with live music?
|
[
"father's day sunset live music dinner cruise."
] |
task469-1e01c7ea66fe476a90fc8ea2c6edb4cf
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
Context: The film begins in medias res, with the suspects getting caught and being interrogated. Then it flashes back to three years earlier and the film continues forward from there, interspersed with occasional bits from the interrogation. Three years before getting caught, Bridget Cardigan (Diane Keaton) lived a comfortable upper middle class life until her husband Don Cardigan (Ted Danson) was "downsized" from his position and sank into debt. The paycheck for Selina, the housecleaner, bounces again. Selina confronts Bridget and suggests she take a job as a janitor at the Federal Reserve Bank of Kansas City. On her first day on the job, Bridget hatches a scheme to steal worn-out dollar bills slated for destruction. For her team she chooses Nina (Queen Latifah), who works the dollar bill shredder, and Jackie (Katie Holmes), who takes bill carts from the Secret Service room to the shredding room. It takes some work to persuade Nina to join, but Jackie joins them quickly. The plan is that in the Secret Service room Bridget will switch a cart's official Master-brand lock with a near identical lock she purchased at Home Depot. Bridget will tell Jackie the cart number and give Nina the official lock. When Jackie gets the chosen cart, she dumps some bills from the cart into a trash can before taking the cart to Nina, who then uses Bridget's key to open it and restores the official lock, and then proceeds to shred the remaining bills. Meanwhile, Bridget, in the course of her janitorial duties, retrieves the dumped bills from the trash and splits them among Nina and Jackie in the women's restroom. Their first robbery is a success though the take is not as big as they had hoped. However, they're emboldened to do it repeatedly. Once Don and Bridget pay off their debt, Don suggests they stop before they get caught. Bridget rejects this idea and persuades Nina and Jackie to keep going. They almost get caught but they end up cutting in Barry (Roger Cross), one of the security guards, who is attracted to Nina. A Federal Bank Examiner shows up at a party at Bridget's house, and the next day Bridget sees him at work. The Examiner confronts Glover (Stephen Root), who is unwilling as a matter of professional pride to admit anyone has stolen a single bill out of his bank. Tipped off, that night Bridget and her accomplices begin trying to get rid of all the loot stashed in their houses, but the cops move in before all the evidence is destroyed. Bridget escapes but the others get caught. Bridget hires a tax attorney to defend them. The lawyer gets Bridget and all her accomplices off the hook for their crimes, because neither the law enforcement, nor the examiner can prove that the large stash of cash in their homes came from the Federal Reserve Bank. Technically, it isn't illegal to have a couple of hundred thousand dollars in cash lying around inside a private residence. However, they spent a large sum of that stolen cash to buy expensive objects and improvements on their houses, and did not pay the taxes for them because they couldn't justify the income. The IRS demands they pay their taxes, which turn out to be equal in amount to the money that still remains. Eight months later, Bridget reveals to Nina and Jackie that she had stashed away much of the stolen money in the basement of a friend's bar.
Question: Bridget stashed away the stolen money in the basement of what type of business?
|
[
"bar"
] |
task469-b64db1d51860402cb5739af2546ecb80
|
question_answering
|
[
"Wikipedia",
"News",
"Natural Science"
] |
mrqa
|
task469_mrqa_answer_generation
|
english
|
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