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We advise careful monitoring of water-electrolytic balance during sibutramine therapy.
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BACKGROUND: Medical therapy for thrombosed valve in pregnancy has become an acceptable alternative to surgery, especially in hemodynamically compromised patients.
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It seems that the favorable outcome of the potentially fatal pneumonia observed in this patient might be related to early diagnosis, and prompt administration of ganciclovir and standard high-dose immunoglobulins.
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Corticosteroids were stopped, and systemic trimethoprim-sulfamethoxazole and topical tobramycin, colistin, chloramphenicol and sulfisoxazole were given.
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Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).
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A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.
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These microorganisms are recognized as the cause of devastating soft tissue infections, such as cellulitis, myositis, and gas gangrene.
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Benign intracranial hypertension should be sought in any young woman complaining of headache during treatment with tetracycline.
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Complete regression of iatrogenic Kaposi's sarcoma due to corticosteroid treatment in a patient with tubercular pericarditis.
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Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.
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Following overdose either agent can affect the central nervous and cardiovascular systems, inducing arrhythmias, conduction disturbances and hypotension.
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Because of the potential severity of this interaction, close monitoring of INR and warfarin dosage adjustment is recommended in patients receiving warfarin along with levamisole and 5-FU.
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We report two cases that developed acute myeloid leukaemia (AML) during tamoxifen therapy for breast cancer.
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Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.
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We found that patients with serotonin syndrome most often (74.3%) presented within 24 hours of medication initiation, overdose, or change in dosage.
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One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol.
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This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis.
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STUDY DESIGN: Case report.
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The strong position taken against narcotic use in Cope's Early Diagnosis of the Acute Abdomen is probably the reason for the perpetuation of the myth of avoiding narcotics for pain relief in patients with undiagnosed acute abdominal conditions.
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Their use in women who are pregnant is not without risk to the fetus.
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Seven patients presented with refractory bleeding and 1 was diagnosed with severe coagulopathy unresponsive to the conventional treatment.
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Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.
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ACE-inhibitors-induced metabolic acidosis in a child with nephrotic syndrome.
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We describe a novel approach to this rare and complicated problem and provide a review of the literature on the subject.
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Video game epilepsy.
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However, in 1993, a clinical study involving 400 patients on the Thai-Burmese border revealed cardiac effects of antimalarial treatment with halofantrine, including one sudden death after the treatment.
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While not life threatening, it can have a severe disruptive effect on the quality of life.
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This case suggests that disopyramide should be used with caution in patients with bifascicular block patterns on ECG.
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DISCUSSION: These findings suggest that paramyxovirus infection had contributed to the development of DIHS in this patient and that there is a need to seek evidence of other viral infections in some cases of DIHS, especially those without herpes virus reactivation/infection.
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When additional indicators of treatment outcome are considered, such as cognitive and occupational and social functioning, it is clear that the overall outcome for schizophrenia is far from satisfactory.
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DESIGN: Interventional case reports.
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Development of hairy cell leukemia in a patient after cardiac transplantation.
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Described here are 2 patients who developed thrombotic microangiopathy of the kidneys after receiving high cumulative doses of the new anticancer drug gemcitabine.
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In addition, the response to a corticotropin stimulation test was abnormal, an indication of suppression of the adrenal glands.
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CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.
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Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir.
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In the third child, the tics ceased after CBZ discontinuation.
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Pentazocine-induced fibrous myopathy and localized neuropathy.
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Cotton-wool spots were found in six patients, retinal hemorrhages in four, and branch retinal vein occlusion in one (one eye).
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Fatty diarrhea occurred after chemotherapy, probably owing to gland destruction by lymphomatous infiltration.
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In November of 2000, the Food and Drug Administration (FDA) requested a voluntary recall of the product from all manufacturers.
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An objective causality assessment suggests that the JHR in our patient was probably related to penicillin.
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The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.
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She was treated with neoadjuvant chemotherapy and developed an accelerated SSc syndrome with pericarditis and cardiac tamponade, with lethal results.
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Panic attacks occurred for the first time in a patient suffering from delusional depression during treatment with a combination of an antidepressant and a neuroleptic.
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The kidney function returned to normal within 1 week.
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We report a 53-year-old-man who developed rippling muscle disease (RMD) 2 months after starting simvastatin therapy for hypercholesterolemia.
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Epidural steroid therapy is a commonly applied "conservative" therapy, but it is not inherently benign.
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The abscess aspirate grew mixed organisms including Kluyvera cryocrescens.
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Seizures associated with ofloxacin therapy.
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This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue.
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Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.
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Infectious complications of this therapeutic regime in severe UC are known but to our knowledge a recurrent sepsis complicating this therapy even after cessation of CyA has not been reported in the literature so far.
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Complications occurring after manual pumping of the reservoir are rare.
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The possible inter-relationship of the cholestatis, central retinal vein thrombosis and immunosuppression are discussed.
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The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients.
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Patients with severe disease and taking combination MTX and corticosteroids are at greatest risk.
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A 78-year-old man with a long history of major depression responded well to a course of ECT but relapsed before maintenance treatments could be started.
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Recently, problems have arisen regarding infection with P. aeruginosa, which produces metallo-beta-lactamase (MBL) and is resistant to virtually all beta-lactams.
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An 8-year-old boy was found to be hypertensive on routine exam (144/88).
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NCSE, an epileptic disorder in which typical convulsive activity is absent, has previously been reported in only 4 patients receiving ifosfamide.
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When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.
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Seizures in patients receiving concomitant antimuscarinics and acetylcholinesterase inhibitor.
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The renovascular hypertension in this patient was treated successfully by renal autotransplantation.
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Pain was reduced in severity by day 29 and completely resolved once tacrolimus was discontinued on day 42.
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This report describes iatrogenic left main thrombosis treated by operative thrombectomy and coronary artery bypass grafting.
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As it was so effective in these eyes with resistant CMO, a larger study is warranted to evaluate this form of therapy.
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The case demonstrates features of leukostasis which are peculiar to the 'retinoic acid syndrome'.
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Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome.
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We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.
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Plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide were measured using high-performance liquid chromatography.
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Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.
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The clinical setting and diagnostic evaluation suggest multiple mechanisms for the hypersensitivity response.
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Etanercept is being tried in patients with congestive heart failure, where TNF-a seems to be increased.
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HDR in young children should be restricted to controlled clinical trials until long-term morbidity and efficacy results are obtained from pilot studies.
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The patient was taking oral corticosteroids for underlying systemic lupus symptoms, and had classic signs and symptoms of peritonitis.
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The diagnosis was based on the rapid onset of renal failure, presence of eosinophilia, skin rash, and characteristic renal biopsy finding, following the administration of ampicillin.
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BACKGROUND: Magnetocardiography and M-mode fetal echocardiography are non-invasive techniques capable of identifying fetal arrhythmias.
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Renal biopsy demonstrated minimal glomerular changes with fusion of podocytes, tubular necrosis with regeneration of tubular epithelial cells, interstitial edema with focal interstitial fibrosis, and interstitial infiltration with neutrophils, eosinophils, plasma cells and mononuclear cells.
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Thiotepa and its main metabolite tepa, ultrafilterable platinum, cyclophosphamide and its activated metabolite 4-hydroxycyclophosphamide were determined.
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We postulate that pulmonary GVHD and pulmonary infection including aspergillosis played an important role in the occurrence of both PVOD and HUS in our patient.
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The infant improved clinically under intravenous hydration therapy, nevertheless lithium serum levels increased again and we did not know for certain if our clinical instinct or the actual figures were correct.
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The possibility can be raised that M-CSF accelerated the underlying renal disease in this case through enhancing macrophage accumulation into the glomerulus, leading to the development of nephrotic syndrome.
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The cases, as compared with the controls, less frequently showed lipodystrophy (4.4 vs. 65.2%, P<0.001) and hypertriglyceridemia (8.8 vs. 56.5%, P<0.005), whereas the prevalence of subjects with hypercholesterolemia was similar in the two groups (30 and 39.1%, respectively).
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Acquired methemoglobinemia: a rare but serious complication.
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CONCLUSION: Long-term treatment with rifabutin may have a reversible and previously undescribed side-effect on retinal function.
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We report a case of amiodarone-induced thyrotoxicosis of protracted duration, unresponsive to conventional thionamide therapy, with therapy limited by severe adverse drug reactions.
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She had been taking nabumetone for 6 months, but had discontinued the agent 2 weeks before admission due to progressive edema.
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The patient was then treated with gemcitabine and irinotecan.
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Indinavir-associated nephrolithiasis and chronic interstitial nephritis were the only possible causes identified in this patient.
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We describe a case that involves fracture of a stent deployed to nominal pressure.
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Calcimimetics are a new class of drugs approved in the European Community and the United States by the Food and Drug Administration that were designed to suppress parathyroid hormone (PTH) levels with a simultaneous reduction in serum calcium and phosphorus levels, and calcium phosphorus product (Ca x P).
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Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective.
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It has a significant effect in relieving motor and vocal tics and in mood and behavior disturbances of children, adolescents, and adults with TS.
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Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.
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In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon.
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Further treatment with intravenous ACV led to VZV DNA becoming undetectable in whole blood, a result not achieved with oral valacyclovir.
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CONCLUSION: In patients presenting with pelvic masses and a history of IUD placement, actinomycotic infection should be considered and diagnosis attempted by imaging guided needle biopsy.
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Seizures in the neonatal period generally respond well to anticonvulsant therapy, but exposure to anticonvulsant medication during the first few months of life may have a detrimental influence on growth and development.
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Although porphyria cutanea tarda may be familial, it is more often sporadic in occurrence, and has been associated with excess alcohol ingestion, estrogen administration, iron overload, and several environmental hepatotoxins.
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