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This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis.
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RESULTS: Ethambutol, and to a lesser extent isoniazid, are both implicated in the development of visually related side effects.
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A 40-year-old man had undergone instrumented posterior lumbar interbody fusion at the L5/S1 level approximately 1 year previously.
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Careful consideration must be made of the choice of environment in which intravenous loading is done (e.g., emergency department, intensive care unit), as dictated by patient parameters, nursing staff levels, and planned disposition.
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We report one case each of CAPD-related peritonitis caused by Aspergillus terreus and Mucor sp., which have previously been described in the literature once and twice, respectively.
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Two heroin addicts, aged 34 and 19 years, developed ballistic movements after intravenous heroin overdose.
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If it is used for diagnostic purposes, resuscitative equipment should be readily available.
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In these patients, long-acting octreotide may trigger serious hypoglycemia.
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Therapeutic options to treat this dangerous imbalance comprise calcium gluconate, insulin plus glucose, albuterol/salbutamol inhalation.
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5-Azacytidine and fetal hemoglobin.
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In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal.
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AIM: To report a patient with diabetic rubeosis who suffered from acute retinal ischemic change and stroke after intravitreal injection of bevacizumab.
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Possible risk of invasive pulmonary aspergillosis with marijuana use during chemotherapy for small cell lung cancer.
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Examination of the bronchoalveolar lavage fluid revealed an increased eosinophil count.
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Hepatitis C virus RNA was negative after 12 mo of treatment.
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Subsequent radiologic examination revealed rachitic bone and joint changes.
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Clearly, more effective therapies are needed for this rapidly lethal disease.
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The mechanism behind this observation may be similar to that of previously reported protease inhibitor-associated fat redistribution, but instead involving the adipose tissue of discrete uncommon benign tumors.
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We here report on two patients who received imatinib in the presence of increased bilirubin and/or cholestasis parameters.
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We suspect a possible cause-and-effect relationship, which has not previously been reported in the literature.
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The patient had received methotrexate alone for more than 10 years without any signs of severe liver damage.
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The VPA concentration following this dose escalation was 392 micromol/L, and the patient improved clinically.
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The first patient developed a histologically documented acute hepatitis and recovered after 3 weeks.
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During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.
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A 17-year-old anuric female patient with end-stage renal failure received a massive overdose of vancomycin and was treated with high-flux hemodiafiltration, as described in this report.
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Aminoglycoside-induced renal toxicity is well known and may manifest with nonoliguric renal failure or renal tubular dysfunction.
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A 74-year-old man with well-compensated systolic dysfunction and longstanding type 2 diabetes mellitus treated with glyburide began therapy with rosiglitazone 4 mg/day, which was increased to 8 mg/day after 1 month.
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He was admitted to the hospital for treatment after failing to improve on oral ciprofloxacin and inhaled tobramycin.
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A 57-year-old woman with end-stage renal disease presumed secondary to chronic glomerulonephritis underwent a living related renal allograft transplantation.
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Aortic transgraft hemorrhage is an unusual complication following thrombolytic therapy that can occur months to years after aortic surgery.
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A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.
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The clinical picture was characterized by visual hallucinations, agitation, anxiety, but no disorientation, and a severe cerebello-myoclonic syndrome with total inability to stand up and walk, which was fully reversible on discontinuing the medication.
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As emergency surgical intervention of thrombotic prosthetic cardiac valves is correlated with high mortality, fibrinolytic therapy has been recently recommended as a therapy with high efficacy and no severe side effects.
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Candida dubliniensis is an emerging fungal pathogen, especially in immunodeficient patients.
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Vancomycin administration led to a good outcome for this patient.
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In this case series, the course of mild to severe OHSS was evaluated in 19 intact twin pregnancies after IVF/ICSI.
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We present a case of an abscess in this site which was a complication of chemotherapy and was the result of haematogenous spread.
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He underwent uneventful cataract extraction surgery and intraocular lens implantation of the right eye.
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BACKGROUND: Platinum-based chemotherapy agents have been associated with potentially fatal acute immune-mediated hemolytic anemia.
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Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain.
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Two patients with RAS responded with a rise in haemoglobin concentration to > 130 g/l.
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Immunophenotyping these lesions revealed a dense LCA+, CD2+, CD3+, CD4+, CD5+, CD7+, CD45+, CD45RO+ T-cell infiltrate admixed with many factor XIIIa+ dendrocytes.
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He required intensive treatment and support for 13 days.
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We present a case of a newly acquired herpetic infection in the graft after penetrating keratoplasty.
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Review of the literature relating to methicillin-induced nephropathy suggests a hypersensitivity origin for this disorder, but immunologic and ultrastructural investigation to date has failed to elucidate pathogenesis.
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In order to develop optimal schedules for exogenous TPO administration it might be important to consider endogenous TPO response characteristics.
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Intravenous haloperidol is generally well tolerated, but multiform ventricular tachycardia has been reported.
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A rare case of advanced ovarian carcinoma who developed difficulty walking 25 days after treatment with weekly paclitaxel.
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Cerebral sinus thrombosis associated with acquired free protein S deficiency is very rare.
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Therapy was discontinued at a cumulative dose of adriamycin of 600 mg/m2.
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He underwent hospital admission, early intubation, intensive care for nine days and hospitalization for six weeks.
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Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.
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Proposed mechanisms include von Willebrand Factor abnormalities, decreased prostacyclin production, and immune complex formation.
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MEASUREMENTS AND MAIN RESULTS: A patient recovering from acute respiratory distress syndrome developed septic shock from Pseudomonas aeruginosa bacteremia while in the medical intensive care unit.
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RESULTS: Onset of symptoms of infection occurred after a mean of 20 days (range, 11 days-6 weeks) after LASIK or an enhancement procedure.
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The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.
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Clozapine was approved by the U.S.
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A striking feature of the neoplasms was cholestasis.
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Magnetic resonance spectra provided a noninvasive means of monitoring CNS response.
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The most-common ocular symptom is colored rings around lights.
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Intractable severe bleeding from his oral mucositis necessitated treatment with a continuous infusion of 8-ornithine-vasopressin for 8 days.
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Teamwork and skillful airway management prevented this patient's demise.
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She was treated with methylprednisolone (40 mg i.v. q6h), aminophylline (loading with 5 mg/kg and maintained with 0.6 mg/kg/hr i.v. drip), nebulized terbutaline sulphate (5 mg q6h), oral procaterol 12.5 micrograms bid, along with oxygen therapy.
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Tolerance of sunitinib in dialyzed patients with metastatic renal cell carcinoma.
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Disseminated fusariosis.
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Also, he developed similar signs and symptoms when he was administered tobramycin intravenously on one occasion at 5 1/2 years.
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This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.
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RESULTS: Two of three melanoma patients had objective responses.
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These measurements (720 before and 832 on therapy) suggested that both early and late dumping symptoms are causally related to the rate of glucose elevation and decline, rather than to glucose peak and nadir, respectively.
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PURPOSE: To illustrate the multiple causes of hypoxemia to be considered following cardiopulmonary bypass and how therapy given to improve oxygen delivery may have contributed to a decrease in arterial oxygen saturation to life-threatening levels.
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Case histories, including medication lists, liver biopsy and laboratory data were reviewed.
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This report describes a case of fatal haemolytic uraemic syndrome (HUS) developing in a child with acute lymphoblastic leukaemia (ALL) during induction chemotherapy.
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Gastric stump lymphoma after distal gastrectomy for benign peptic ulcer: Report of a case.
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Clonidine: a practical guide for usage in children.
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MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction.
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The patient developed occipital infarcts and was found to have extremely elevated levels of PPA in his blood and dialysis fluid.
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CASE SUMMARIES: In each case, the patients were treated over 5 years with lovastatin and developed rhabdomyolysis that coincided with the completion of a prescribed regimen of a newer macrolide antibiotic.
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Interaction between methotrexate and ciprofloxacin.
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In 6 dogs with multicentric lymphosarcoma, salmonellosis developed shortly after the start of anticancer chemotherapy.
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After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.
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Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased.
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Bilateral ear infections, central nervous system lymphoma and infection, or other drug-induced neuropathies were excluded as possible etiologies for the deafness.
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He was kept for observation, recovered well, and was discharged with prescriptions for prednisone and diphenhydramine hydrochloride.
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Treatment consisted of catecholamines and repetitive infusions of Ringer lactate.
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Again, the pneumonitis was fully reversible.
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It was concluded that potassium loss occurred by a non-renal (intestinal) route in phosphate-induced hypokalemia.
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Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy.
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It's much better now and I have more energy." Such comments justify our efforts on our patients' behalf.
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It has also been advocated as an intervention for diagnostic use to assess uncommon types of tachycardia.
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Although renal function showed gradual improvement after seven days of anuria, the recovery was slow and incomplete.
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Liposomal amphotericin B in drug-resistant visceral leishmaniasis.
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For the treatment of secondary hyperparathyroidism (HPTH-II) in dialysis patients and hypercalcemia in patients with parathyroid carcinoma.
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As a clinical entity atrioventricular (AV) block due to hypothyroidism is rare.
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Exceptionally long status and stupor increase the risk of medical complications.
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However, its clinical utility in CMV treatment has not been described previously.
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RESULTS: The patients sought treatment ten to 20 weeks (mean, 15 weeks) postoperatively.
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Given that psychiatric symptoms are not included in the manufacturer's lists of adverse drug reactions, the incidence may be significantly higher.
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A 33-year-old male presented with brown discolouration of the fingernails following the application of 4% hydroquinone in sorbolene cream and 0.1% tretinoin cream to the face intermittently for 9 months.
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Irinotecan is metabolized by carboxylesterase to form an active SN-38, which is further conjugated and detoxified by UDP-glucuronosyltransferase (UGT) to yield its beta-glucuronide.
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In such cases, conservative, nonsurgical measures, such as treatment with botulinum toxin, will provide excellent results.
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