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By day 8 the patient was comatose, with minimal signs of brain activity and little hope for recovery; on day 12 he died.
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Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.
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RESULTS: After a single PDT treatment, visual acuity increased from 20/50 to 20/20.
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Malignant lymphoma involving the penis following malignant pleural mesothelioma.
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Acute adrenal insufficiency after large-dose glucocorticoids for spinal cord injury.
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The cervical sympathetic chain is composed of superior, middle, intermediate, and inferior cervical ganglia.
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CT showed deep RIF extending from the vocal cords to the carina, with laryngotracheal compression but without cancer recurrence.
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The first FAB infusion (320 mg) was started 11 h after drug ingestion.
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An epidural blood patch was performed and enoxaparin was prescribed for 6 months.
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BACKGROUND: Vicks VapoRub (VVR) [Proctor and Gamble; Cincinnati, OH] is often used to relieve symptoms of chest congestion.
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This is probably the first case report of motile Enterococcus infection of the central nervous system.
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Uses and safety of acyclovir in pregnancy.
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There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.
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We report of a 32-year-old man who showed dystonic symptoms within few days after liver transplantation (LT).
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The second patient developed both autoimmune thyroid disease and a refractory pre-patellar bursitis after 50 months of IFN-beta therapy.
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Four years after achieving CR, she developed complicated life-threatening pulmonary infections with methicillin-resistant Staphylococcus epidermidis and Aspergillus niger during outpatient care.
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A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive pleuropulmonary abnormalities during the latter therapy.
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Drug-induced lymphocyte transformation test before desensitization was negative with a stimulation index of 130%.
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There are few published reports that discuss oral burns in children.
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A paradoxical ocular effect of brimonidine.
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Small cell carcinoma of the lung is the tumor most commonly associated with ectopic ACTH production and hypercortisolism.
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A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman.
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OBJECTIVE: To report the first five cases of amphotericin B overdose with secondary cardiac complications in a pediatric population.
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Pseudoephedrine-induced hemorrhage associated with a cerebral vascular malformation.
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WE is attributable to thiamine (vitamin B1) deficiency.
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This is of concern, particularly in a context of increasing use of immunosuppressive drugs in UC.
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A diagnosis of acute transverse myelitis was made and the patient was treated with IV methylprednisolone and IV immunoglobulin.
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A thorough examination at the hospital gave no evidence of underlying diseases that could explain the reaction.
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A 7 year-old Turkish boy presented with a euthyroid goiter, which was noted during evaluation of familial Mediterranean fever.
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Familiarity with these hair practices will aid in the accurate diagnosis, prevention, and proper management of this problem.
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Up to now, however, its healing effect on bronchiectasis has never been demonstrated.
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HCV RNA was positive in serum, and chronic HCV infection was detected by liver biopsy.
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Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.
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Confidence and conditional confidence levels for the preferred decision are derived from gaussian theory, and the mutual information index that identifies probabilistically important tree variables is provided.
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Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.
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During IFN therapy, he had normal aminotransferase levels and no detectable HCV RNA, a condition that persists to the present.
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Ileal ulcers and cytomegalovirus infection in a case of Churg-Strauss syndrome.
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In the other 2 patients, hyperintense lesions in the periventricular white matter were transient and no neurologic sequelae ensued.
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It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome.
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The patient's isolate was susceptible in vitro.
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Acute INH neurotoxicity was not suspected on the first admission; however, when readmitted 4 weeks later with another seizure, the diagnosis of acute INH neurotoxicity was made.
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CONCLUSION: With anti-tuberculous treatment, renal functions and visual disturbances were improved in a patient with miliary tuberculosis.
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His dibucaine number was 21, and the Michaelis constant was 5.5 times that of normal sera.
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Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy.
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We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents.
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There were no complications of persistent bacteremia despite placement of the stent-graft device at the site of primary infection, reinfection, delayed rupture, paraplegia, distal emboli, or surgical conversion.
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According to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of her acute pancreatitis.
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She did not experience any reactions.
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Treatment with heparin may be of help in situations where there is a delay in elimination of the underlying cause.
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We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.
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We describe nine patients with cardioembolic stroke who experienced clinical deterioration associated with computed tomography-documented hemorrhagic transformation.
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Aggressive suppletion with intravenous potassium and bicarbonate combined with potassium-sparing diuretics and ACE inhibitors resulted in complete restoration of the serum potassium and resolution of the neurological symptoms.
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There was resolution of the inflammation; however, bullous keratopathy was subsequently noted in the cornea.
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After the most recent surgery, he suffered transient cauda equina symptoms.
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BACKGROUND: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy.
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Statistical significant risk factors for the developing of visual disturbances were found to be the ingested quantity of methanol, the latent period, acidosis and serum methanol concentration on admission.
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We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B.
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A review of the literature showed no previous description of this pattern in benzodiazepine coma.
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We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.
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Upon review of the literature, this appears to be the first documented case of drug-induced photosensitisation in the cat.
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Metformin is described as a glucose-lowering agent for treatment of type 2 diabetes mellitus and as antiobesity drug, though results achieved with this last indication are not conclusive.
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Although this G-CSF-driven leucocytosis was alarming it did not appear to have adversely affected the patient's prognosis.
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We discuss a patient with a history of a positive tuberculin skin test, who presented with severe, recalcitrant palmoplantar pustular psoriasis with psoriatic arthritis whose symptoms did not resolve with monotherapy of etanercept (Enbrel) or efalizumab (Raptiva) alone, but did respond to a combination of both biologics.
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Each was analyzed to determine a mechanism of the hypersensitivity reaction and subsequent management outcomes.
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The lesions were lichenoid in appearance and this was confirmed histologically.
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Apparently, the subacromial injection penetrated the anterior half of the supraspinatus tendon, causing a transient effect and signal change.
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BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.
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However, a method to differentiate the neuromuscular block induced by magnesium from that induced by curariform nondepolarizing muscle relaxant in the clinical setting has never been reported.
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We recommend that bisphosphonates be used with caution in patients with myeloma and renal impairment, that vitamin D deficiency be corrected prior to treatment (to reduce the risk of hypocalcaemia) and that serum calcium and renal function be monitored during treatment.
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Bone marrow aspiration revealed cell maturation arrest.
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Here, we present an angiosarcoma of the neck occurring after curative chemoradiation.
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Circadian rhythm of white blood cells during clozapine treatment.
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We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimodipine.
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CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.
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The patient was not obese.
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It is usually a consequence of direct extension from an underlying bony lesion, in the setting of multiple myeloma.
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Neurologic disturbances (ataxia and prostration) were significant clinical findings.
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We report three cases of ophthalmic problems that were treated with a short course of oral corticosteroids and which resulted in the development of hyperosmolar hyperglycemic nonketotic coma.
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An unusual patient with post-transfusion purpura is described who had a rapidly rising platelet count with high dose steroid treatment in the presence of an increasing anti-PlA1 antibody titre.
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Three patients with major depression superimposed on chronic dysthymia were treated with phenelzine.
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Interventional pain management is an evolving field, with a primary focus on the safety of the patient.
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CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.
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The authors report the first case of bucillamine-induced giant mammary hyperplasia.
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The respiratory rate improved within 5 to 10 minutes of methylene blue administration and continued over a period of 2 hours.
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The fourth patient showed RLS symptoms that were initially caused by a 20-mg daily olanzapine dosage and were later mitigated when olanzapine was reduced and ropinirole was administered.
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We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication.
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The patient recovered clinically and, in less than 4 weeks, her serum bilirubin and aminotransferases returned to normal levels.
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A report on two cases.
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This case highlights the importance of muscle biopsy in HIV infected patients whose myopathy persists despite withdrawal of antiretroviral therapy and the need for thorough investigation of non-specific symptoms in HIV infected patients who are receiving antiretroviral therapy.
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The patient attained a final height of 160.8 cm, which was appropriate for her target height.
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PATIENTS: Three patients developed a reproductive endocrine disorder during treatment with valproate.
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A 50-year-old woman with migraine was admitted to hospital shortly after having abruptly developed hemiparesis.
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At 29 months of age, she developed diarrhea with bulky stools and weight loss.
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We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.
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Acute pulmonary reactions to nitrofurantoin are an uncommon side effect of therapy and can cause minor or life-threatening pulmonary dysfunction.
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Effect of a GnRH analogue (leuprolide) on benign prostatic hypertrophy.
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Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine: case report and review.
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One male patient with bilateral DME was treated by intravitreal pegaptanib in his right eye every 6 weeks for 6 months (five injections) and followed for 42 months.
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This case describes a 52-year-old white woman who developed a spontaneous nasal septal perforation after given the antiangiogenic drug, bevacizumab, for metastatic ovarian cancer treatment.
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The relative etiologic significance of the stress of status asthmaticus, administration of theophylline, or corticosteroids is open to question.
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