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These remained the only agents for the next 50 years.
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Subsequently, he developed symptoms typical of GHD and, after biochemical confirmation, GH replacement was commenced.
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Organ transplant recipients are generally considered to be at greater risk for developing malignant disorders because of prolonged immunosuppression for organ grafting, but acute leukemia is a rare complication after organ transplantation (0.2 -2.5%).
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Conversion of ischemic to hemorrhagic infarction has been shown to occur experimentally.
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Despite intensive supportive measures and specific therapeutic attempts, all three patients eventually died of septic shock.
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OBJECTIVE: To report a case of toxin-positive Clostridium difficile-induced colitis (CDIC) after use of clindamycin phosphate vaginal cream.
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Acrodermatitis enteropathica with SMON almost always has a high occurrence of visual impairment, but other sensory disturbances are slight or absent, while common adult SMON is just the opposite.
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Thrombolytic therapy in acute cerebral infarction complicating diagnostic cardiac catheterization.
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Pancytopenia is a rare complication of the thionamide therapy reported secondary to aplastic anemia, the bone marrow being invariably hypocellular.
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RESULTS: Microscopic examination of smears revealed Acanthamoeba cysts and non-nutrient agar showed a significant growth of Acanthamoeba.
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Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).
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The patient then received combined cataract and glaucoma surgery.
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Successful treatment of tardive and spontaneous dyskinesias with corticosteroids.
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The pacing system was removed in one patient 13 months postoperatively because of persistent pericarditis; one patient died of an unrelated cerebral hemorrhage 13 months postoperatively.
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However, whether or not the microgranulations were bacterial colonies, infection did not recur during a 2-year follow-up period.
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Its etiology has still not yet been fully resolved.
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The tolerance of sunitinib in the setting of dialysis can be challenging as these interventions can have synergistic side effects.
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Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.
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While still receiving the drug or shortly thereafter, two patients were found to have abnormal dark-adaptation curves, with elevations of either cone or rod thresholds, or both.
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We report 2 cases of severe, persistent erythema multiforme, treated with thalidomide, with complete disease suppression in both cases.
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Of the 16 patients, including the 1 reported here, only 3 displayed significant shortening of the agranulocytic period after treatment.
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He was successfully transplanted.
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We present the case of a patient who had undergone cholecystectomy previously, but in whom morphine given in the Emergency Department precipitated pain consistent with biliary colic; the pain resolved promptly after administration of naloxone.
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RESULTS: The treatment regimen resulted in two complete regressions, five partial responses, and one mixed response, and two patients did not respond to the treatment.
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Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non-Hodgkin's lymphoma.
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Sirolimus-associated hepatotoxicity in the kidney graft recipient.
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OBJECTIVE: To report a case of HIV-related lipodystrophy with a rapid onset of symptoms from epidural lipomatosis in the wake of protease inhibitor and steroid treatment.
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Timolol side effects and inadvertent overdosing.
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Reactivation of sarcoidosis during interferon therapy.
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A 15-month-old girl with rhinopharyngitis was treated with a nasal solution containing the imidazoline derivative naphazoline.
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We also provide a literature review regarding thionamide-induced ANCA-associated vasculitis.
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We present a 16 month-old previously healthy boy with refractory hypercalcemia due to an overdose of an over-the-counter vitamin supplement.
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A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.
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The pathogenesis of chemotherapy-associated thrombotic microangiopathy (C-TMA) has not been established.
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This report describes 2 generations of a family with symptoms of sensory overstimulation that exhibit a potassium sensitivity similar to that seen in hypokalemic periodic paralysis.
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Fungal arthritis and osteomyelitis are rare and documented mainly in immunocompromised or neutropenic patients.
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CASE REPORT: A case history of unanticipated radiation-induced bilateral optic neuropathy, 18 months after induction chemotherapy and radiation therapy for a locally advanced nasopharyngeal carcinoma, is presented.
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Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis.
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After recovery, the children tolerated continued chemotherapy without any decrease in the doses of drugs.
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Triad of severe abdominal pain, inappropriate antidiuretic hormone secretion, and disseminated varicella-zoster virus infection preceding cutaneous manifestations after hematopoietic stem cell transplantation: utility of PCR for early recognition and therapy.
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PATIENTS: Two infants and three children inpatients receiving amphotericin B.
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Anaphylaxis to calcitonin.
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The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.
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Use of somatostatin for complications occurring after liver transplantation.
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RESULTS: All three patients responded to risperidone and experienced no extrapyramidal side effects.
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Anterior ischemic optic neuropathy: a complication after extracorporal circulation.
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The proliferating cells were of T lineage and further typing demonstrated that they bore the OKT8 antigen.
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The second patient was a 4-day-old neonate with congenital precursor-B cell acute lymphoblastic leukemia who presented with spontaneous TLS complicated by renal dysfunction.
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An 18-year-old female with alpha-1 antitrypsin deficiency underwent living donor liver transplantation and presented 6 months later with a liver abscess.
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Platinum agents and secondary myeloid leukaemia: two cases treated only with platinum-based drugs.
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Close monitoring for the development of a deep thrombosis of the popliteal vein is required.
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During the three years of follow-up, both pulmonary sarcoidosis and hepatitis C have not recurred.
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Neurotoxicity of intrathecal administration of amphotericin B.
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Electrical stability was achieved and the patient was discharged on propranolol 400 mg/day.
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The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.
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Therefore, we recommend that regular examination for TD using the activation procedure should be performed in patients who use clozapine on a long-term basis.
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Finally, reserpine toxicity, in particular central nervous system (CNS) disturbances, was reported more frequently in patients also receiving barbiturates, suggesting additive CNS effects.
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Clinical trials of patients treated de novo, in first relapse, and with resistant disease have achieved a high rate of complete remission (CR).
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A review of the literature revealed that Paecilomyces species are an infrequent cause of disease in transplant patients, with skin and soft tissue infections being the most common presentation.
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The patient appeared to be homozygous for the dibucaine resistant gene, having only 15% of normal activity in his serum.
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Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.
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In the second patient, a mild augmentation of liver enzymes occurred, followed by normalization in a few days.
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The leukemic blasts were examined by morphological, immunohistochemical, cytogenetic, and molecular genetic analyses.
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The neurologic toxicity can vary from being mild to severe and prolonged.
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One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).
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The optimal treatment is not well defined.
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A significant feature of this group is its resistance to almost all presently available antibiotics including penicillin, the cephalosporins, and the aminoglycosides.
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The targeted therapy gefitinib was prescribed 2 years after diagnosis, producing a very good partial response.
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Transplant physicians should be aware of this unusual pathogen and the potential for both persistent line-related sepsis and possible septic arthritis.
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Atypical antipsychotic induced hypothermia is a rare adverse effect that may present with mild to severe symptoms.
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Leiomyosarcoma in urinary bladder after cyclophosphamide therapy for retinoblastoma and review of bladder sarcomas.
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Case report.
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We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.
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1. Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low-dose alprazolam treatment (mean 0.62 +/- 0.15 mg/day) compared with during the period of high-dose period (mean 1.08 +/- 0.28 mg/day).
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Patients whose trigeminal branches have been subjected to repeated surgical procedures and who have relentless unilateral face-jaw pain should be classified as having chronic traumatic trigeminal neuralgia.
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A percutaneous liver biopsy obtained from one of the patients showed ultrastructural abnormalities consistent with a toxic hepatitis and hepatic congestion.
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Nasogastric glutamine-supplemented tube feedings were well tolerated both in the hospital and at home.
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Furthermore, 8-hydroxy-deoxyguanosine (8-OH-dG) was prominently increased in mitochondrial and nuclear DNA.
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The patient died 5 months after MAHA was diagnosed.
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The presentation in humans appears similar to that in dogs where cardiac arrhythmias occurred at doses of 5-15 mg/kg.
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Attention should be directed towards prevention by the identification and immunisation of at risk patients prior to transplantation.
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In patients with cirrhosis, the metabolism of meperidine is decreased, leading to accumulation of the parent drug and possible CNS depressive effects similar to hepatic encephalopathy.
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The common systemic diseases that may give rise to gynecomastia were excluded.
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Extrapulmonary disseminated tuberculosis also involving bone and liver was eventually diagnosed and proven by means of specific polymerase chain reaction assay.
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We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).
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The Patient conceived 2 years after completing therapy and gave birth at term to a normal infant.
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This therapy was curtailed after three cycles because of nausea, asthenia, and neuropsychological deterioration.
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Over the course of 2 months, the wound healed with systemic antibiotics.
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In all cases, ACE-inhibitor therapy either predisposed the patient to or precipitated the acute event.
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A Meckel diverticulum is an embryonic remnant of the vitellointestinal duct.
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Recently, some studies have also reported association between patients with juvenile rheumatoid arthritis (JRA) treated with Methotrexate (MTX) and malignant lymphoma developing.
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Syncope induced by propranolol in hypertrophic cardiomyopathy.
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Further studies are necessary to evaluate whether the study of HLA antigens may be a very useful tool to detect the patients with a predisposition to develop autoimmune thyroiditis, in order to make a early diagnosis of thyroid disorders during the IFN-alpha treatment.
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The effects of proton pump inhibitors on the pharmacokinetics of atazanavir and amprenavir (administered as fosamprenavir) were rigorously evaluated in healthy volunteers in two studies, but formal studies in persons infected with human immunodeficiency virus (HIV) are lacking.
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CONCLUSIONS: The administration of prostaglandin E1 to neonates can cause gastric-outlet obstruction due to antral hyperplasia.
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Neuroleptic malignant syndrome due to atypical neuroleptics: three episodes in one patient.
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Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.
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After discontinuing those drugs, the ST segment elevation in leads V(1) and V(2) became reduced.
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Joint infections by mycobacteria are clinically indistinguishable from those caused by more common bacterial pathogens and, therefore, diagnosis is often delayed.
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We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.
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