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Multiple retinal infiltrates, placoid subretinal lesions, and ground-glass opacity of the retina with hyperemic optic discs were observed in both patients.
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Delayed-onset multifocal polymicrobial keratitis after laser in situ keratomileusis.
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A woman, aged 39 years, presented with a localized, painful, pustular eruption of the neck, scalp, and finger of five years' duration.
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Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug.
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Renal biopsy showed acute interstitial nephritis with eosinophilic cells.
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The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.
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Chromosomal analysis showed some abnormalities.
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Procarbazine is a chemotherapy methylating agent that has been used in combination with other drugs, perhaps most successfully in the treatment of Hodgkin's disease.
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Interventional pain physicians have considerable interest in identifying techniques which avoid these complications.
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After 2 months, she developed a severe depressive syndrome which lead to suicidal ideation.
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Our case report highlights the need to remain alert for unusual manifestations of syphilis in immunosuppressed patients.
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The association of phenothiazine overdose and respiratory distress syndrome merits consideration.
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Bisphosphonates, cancer, and osteonecrosis--a single practice experience.
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When she came to the emergency room her sodium concentration was 127 mmol/L.
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BACKGROUND: Cytomegalovirus (CMV) associated with thrombotic microangiopathy (TMA) in transplant patients has not been extensively described.
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It carries a well-known risk of neutropenia and agranulocytosis, which necessitates the immediate discontinuation of clozapine.
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However, its specific role in our patient remains uncertain.
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Adalimumab may be effective for the treatment of PPP.
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Bronchospasm induced by cardiopulmonary bypass.
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Because of their self-limiting nature, the importance of avoiding unnecessary and potentially deleterious antithyroid treatment is emphasised.
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It also illustrates the need for continued clinical evaluation of patients with metastatic prostate cancer, even in the face of PSA response.
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OBJECTIVE: To report a case of a diffuse papular eruption following treatment of psoriasis with methotrexate injections.
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In the case of SSTIs, alternative treatment of these infections should be considered, especially when the bacterial pathogen is unknown.
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Frequent blood monitoring in search for any pronounced or sustained drop in red, white or platelet count, even within normal range could serve as a warning sign for myelotoxicity.
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The cases described suggest the need for caution when considering tricyclic pharmacotherapy in juveniles with severe depressive disease.
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Polymerase chain reaction (PCR) detected CMV-DNA in the aqueous humor in his affected eye, and we started administration of ganciclovir.
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A pharmacokinetic interaction between the selective serotonin reuptake inhibitor citalopram and a tricyclic antidepressant, clomipramine, was noted in a patient treated for major depression and obsessive-compulsive disorder.
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Two other patients who did not receive prochlorperazine, developed retinal problems which later improved, one after only 15 g of desferrioxamine.
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Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient.
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We report what is to the best of our knowledge the first case of multifocal osteomyelitis following disseminated infection in a patient after haematopoietic stem cell transplantation.
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Efficacy and safety of Etanercept, high-dose intravenous gammaglobulin and plasmapheresis combined therapy for lupus diffuse proliferative nephritis complicating pregnancy.
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We report three patients, all of whom had preexisting diabetic dyslipidemia, who showed a profound reduction in plasma HDL cholesterol and apolipoprotein AI levels soon after the initiation of rosiglitazone therapy.
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Mucopurulent conjunctivitis and exposure keratitis developed in several patients and spontaneous corneal perforation developed in one.
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Treatment with naloxone resulted in rapid reversal of signs without sequelae.
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With the increased use of neoadjuvant chemotherapy, it is important to recognize previously undescribed mammographic findings secondary to this therapeutic approach.
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Trigeminal trophic syndrome with features of oral CMV disease.
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He was initially treated with intravenous fluids and opiate analgesia.
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Culture was positive for Staphylococcus haemolyticus.
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In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.
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CASE REPORT: A 64-year-old man was evaluated for chronic low-back pain after multiple spine surgeries.
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During that time,weight issues and diabetes status were not addressed.
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Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as "red man syndrome" and anaphylaxis.
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Systemic venous thrombosis after recombinant factor VIIa in the control of bleeding after cardiac surgery.
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Verapamil is widely used for the termination of paroxysmal supraventricular tachycardia (PSVT) with little proarrhythmic effect.
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Ezetimibe is a lipid-lowering agent that inhibits the intestinal absorption of cholesterol and other related phytosterols.
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An unusual case of Lafora body disease.
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The most likely cause of such hyponatremic episode is vinblastine.
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Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis.
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Leuconostoc bacteremia after liver transplantation: another cause of vancomycin resistant gram-positive infection.
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The underlying mechanism as well as the treatment of hypokalaemia and hyperchloraemic metabolic acidosis after ureterosigmoidostomy are briefly discussed.
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The first patient, a 9-year-old girl, had severe panuveitis complicated by traction retinal detachment, eventually requiring vitrectomy.
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The 5 patients had severe renovascular disease which might thus represent a significant risk factor in the development of captopril-induced acute renal failure.
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A less well known phenomenon is paradoxical seizures.
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Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.
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Rarely, liver synthetic function is sufficiently severe to warrant liver transplantation.
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Three patients with life-threatening manifestations of systemic lupus erythematosus (SLE), unresponsive to conventional high-dose corticosteroid and/or immunosuppressive therapy were treated with intravenous polyspecific IgG (IVIG).
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Trichiasis associated with prostaglandin analog use.
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Patients were assessed weekly during CAP-XRT and q 3 weeks during CAP alone.
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The 2 cases were remarkably similar in terms of the offending substance, quantity consumed, and subsequent reaction.
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Recombinant Factor VIIa (FVIIa) can be used to reverse coagulopathy in patients on coumadin who sustain a traumatic injury.
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Propranolol-related bronchospasm in patients without history of asthma.
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Culture of a CT guided needle aspiration revealed Francisella tularensis.
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The diagnosis of multiple myeloma was made in two white men, aged 55 and 59 years.
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METHODS: A patient who developed dramatic, permanent vision loss after a 9-month course of treatment with ethambutol and isoniazid for pulmonary tuberculosis is presented.
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L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia.
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Management of a large organized intraatrial catheter-tip thrombus in a child with acquired immunodeficiency syndrome using escalating tissue plasminogen activator infusions.
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The patient's INR had been stable and within therapeutic range (goal 2.0-3.0) for the previous 3 months with warfarin 27.5 mg/wk, but became subtherapeutic after 10 days of bosentan therapy.
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Although it is very rare, careful monitoring and readiness for the occurrence of such a potentially lethal situation with necessary medications may prevent a fatal outcome.
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Several days were required for the aPTT to decrease after stopping the argatroban infusion.
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Reversible posterior leukoencephalopathy syndrome (RPLS) is a syndrome manifested by headache, nausea, vomiting, seizures, cortical blindness, and visual disturbances.
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In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient.
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The remaining deaths were non-MTX related, but all 5 autopsies showed some degree of cirrhosis.
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The pulmonary symptoms recurred after discontinuing corticosteroids, five months after amiodarone was stopped, and were associated with a persistent amiodarone level.
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A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.
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Subsequent use of pamidronate was associated with milder inflammation in the same eye that eventually resolved with continued monthly infusions, indicating the possibility of immunologic tolerance.
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The symptoms returned and worsened over the next 4 days, and she returned to the emergency room stuporous.
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CONCLUSION: Psychiatric illness should not rule out the possibility of interferon-based therapy, but it calls for close integration of psychiatric and medical care and individualized decision-making based on the biological and psychosocial circumstances of each case.
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After the patient discontinued the use of the glucocorticoid eyedrops, his cushingoid features gradually faded, and his blood pressure and serum glucose levels normalized.
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Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.
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Fifteen days later, blood tests showed CK 1327 IU/L and myoglobin 324 U/L; therefore, the drug was discontinued.
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Actinic prurigo and solar urticaria are uncommon chronic idiopathic photodermatoses in the United Kingdom.
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This case illustrates the need for close ECG monitoring during ritodrine treatment when clinical symptoms arise.
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Chemotherapy schedules including alkylating agents were administered for 1 year, resulting in subsequent remission of the lymphoma.
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There has been no literature which reports a case of interstitial lung disease associated with sorafenib.
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BACKGROUND: Hepatitis C (HCV) infection is a major cause of liver disease, cirrhosis, and hepatocellular carcinoma.
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Two of our patients developed septic shock and deteriorated whereas one patient improved and recovered completely.
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Patients who develop these reactions whilst receiving GSTM can be successfully changed to aurothioglucose.
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Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.
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Early diagnosis and appropriate treatment with intensive topical corticosteroids is essential to successfully manage this post-crosslinking complication.
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Rituximab (chimeric anti-CD20 IgG1 monoclonal antibody) is effective in the treatment of relapsed/refractory low-grade lymphomas of B-cell origin as well as in diffuse large B-cell lymphoma.
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However, the use of lithium should be avoided with any patient who is purging, since it may exacerbate the loss of intracellular potassium, thereby increasing the risk of cardiac toxicity.
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Risk factors include previous episodes, dehydration, agitation, polypharmacy, and the rate and route of neuroleptic administration.
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We report 3 cases in whom aspirin was indicated for secondary prophylaxis of myocardial infarction but in whom a remote history of an untoward reaction to it prevented its initial use.
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Peritonitis remains a significant cause of morbidity in ESRD patients undergoing continuous ambulatory peritoneal dialysis (CAPD).
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The possible role of both chemotherapy and the immunodeficiency associated to angioimmunoblastic lymphadenopathy in the pathogenesis of the leukemia is discussed.
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Its major side effect of anaemia limits its use in some patients.
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The patient began her prescribed radiation therapy and 5-fluorouracil radio-sensitizing chemotherapy.
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This therapeutic strategy resulted in normalization of the elevated EBV-DNA titers and disappearance of the monoclonal B cell populations.
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Spectral domain optical coherence tomography and angiographic findings in central serous chorioretinopathy complicated by bilateral nonrhegmatogenous retinal detachment associated with systemic corticosteroids.
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A literature search conducted to determine the mechanism behind the antagonism of this overdose showed that promethazine interacts with receptors in the central nervous system.
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