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This report demonstrates that PET scintigraphy might be a helpful tool in the early diagnosis of drug-induced pulmonary toxicity.
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Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.
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A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.
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A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity.
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Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.
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Both tacrolimus and nefazodone are metabolized by the cytochrome P450 (CYP) 3A4 system.
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Dapsone, a synthetic sulfone with chemical similarities to sulfapyridine, has been used for a number of years to treat leprosy and dermatitis herpetiformis.
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Statin-associated myasthenia gravis: report of 4 cases and review of the literature.
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Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.
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OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.
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The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.
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Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system.
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She had been treated with AZ, 500 mg per every day for eleven days for the treatment of glaucoma.
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The patient was treated with surgery and combined cytotoxic chemotherapy.
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BACKGROUND: Radiation recall pneumonitis describes a very rare reaction in a previously irradiated area of pulmonary tissue after application of pharmacological agents.
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It is harder to evaluate the benefit of a new technology in the face of noncomparable previous technologies.
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With serious cases, however, conventional treatment may not allow sufficient time at depth for the complete resolution of manifestations because of the need to avoid pulmonary oxygen toxicity which is associated with a prolonged period of breathing compressed air.
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He is well at 9 months follow-up.
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METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.
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A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.
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No systemic antibiotics would be given.
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The PSG reports of four other adult groups were also reviewed: periodic limb movement (PLM) disorder (n = 28); sleep terror/sleepwalking (ST/SW) (n = 54); rapid eye movement (REM) sleep behavior disorder (RBD) (n = 70); patients with clinically unremarkable sleep during two consecutive PSG studies (n = 30).
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The liver biopsy showed extensive ground-glass hepatocytes and thin septum-like fibrosis that formed portal-to-portal linkage.
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We recommend that clinicians monitor patients for signs and symptoms of pancreatitis, including abdominal pain, during treatment with tigecycline.
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CASE: We present here the case of a patient with protein S deficiency, who has used COCs together with anticoagulatory therapy (Phenprocoumon) after suffering from deep venous thromboses for 4 years.
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Jaundice was the presenting symptom in all three.
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CONCLUSIONS: Bosentan may significantly decrease the anticoagulant properties of warfarin.
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Ziprasidone is an atypical antipsychotic drug that is believed to have a low propensity for inducing extrapyramidal symptoms, including tardive dyskinesia (TD).
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Of those 18 patients who completed a full course of therapy, seven (39%) experienced a relapse; five of these were cured of their infection with a second course of antimicrobial therapy, which usually included higher doses of intravenous penicillin.
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Theophylline intoxication following viloxazine induced decrease in clearance.
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Pre-diabetic immune markers were repeatedly negative, and no diabetes has developed after four years of follow-up.
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In clinical practice, serum level monitoring of anticonvulsant drugs is usually adequate.
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Many surgeons are reluctant to use these devices because of the costs and the potential risks of inserting metallic or plastic elements into a septic joint.
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Despite the patient's abnormal baseline kidney function, the very high doses of lifoAmB were well tolerated and did not result in additional renal toxicity.
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The evolution is fairly stereotypical and is marked by a regression of the lesions following a dose reduction or curtailment of interferon.
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Herein we report a severe adverse reaction to adalimumab in a 25-year-old female patient.
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However, in some patients, pericardial inflammation resolves without progressing to chronic constrictive pericarditis.
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Thus, the effect of antidiabetic agents on cardiovascular health and safety must be considered when selecting the most appropriate therapy.
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At time of writing, there was no evidence of any increase in CK, myoglobin, or other markers of rhabdomyolysis.
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Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559).
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Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding.
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BACKGROUND: Drug-induced hypersensitivity syndrome (DIHS) is characterized by a severe multiorgan hypersensitivity reaction that usually appears after prolonged exposure to certain drugs and may be related to reactivation of herpes viruses.
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Atrial fibrillation was induced by diltiazem in two patients and verapamil induced syncope in one patient.
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The case reports are followed by a brief review of the literature on differential diagnoses, risk factors, early signs and treatment data.
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CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.
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We report the use of pamidronate for acute, severe hypercalcemia secondary to iatrogenic vitamin D poisoning.
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Over a 36-hour period, insulin was progressively decreased and finally stopped because of the rapid fall and normalization of blood glucose concentration.
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We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.
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The case is reported of a 45-year-old woman who was being treated for chronic back and right leg pain with intrathecal morphine administered via a subcutaneous continuous-infusion device.
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A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.
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Glaucoma secondary to epithelial downgrowth and 5-fluorouracil.
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We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.
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A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes.
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The effect of the methylprednisolone (MP) pulse therapy on renal function was examined in 15 patients with renal or collagen disease.
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We describe two patients with profound hypothalamic-pituitary-adrenal axis suppression resulting from the unregulated use of super potent topical corticosteroids.
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Development of Peyronie's disease during long-term colchicine treatment.
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Hepatic infarction caused by an embolus from an atherosclerotic lesion--a case report.
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We report a patient with psoriasis and HCL who was treated for 1 week with continuous intravenous infusion of 2-CdA for recurring HCL.
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2. Prior to the advent of chemotherapy, this complication was not observed in large series of patients with lymphoproliferative disorders and multiple myeloma.
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Early diagnosis and medical treatment alone can result in resolution of corneal infiltrates due to acanthamoebae.
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There were no other neurological abnormalities and more particularly, no seizures or myocloni were observed.
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After 14 days of therapy, he was taken to the emergency department with a 3-day history of fever, headache, and neck pain.
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We describe a 64-year-old man with diabetes, chronic kidney disease, and anemia who was treated consecutively with epoetin alfa and darbepoetin alfa and experienced a temporal reduction in A1C level to a nadir of 4.4%.
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A patient in our hospital had ventriculitis caused by coagulase-negative staphylococci, and under neuroendoscopy we obtained clear findings of granular ependymitis.
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OBJECTIVES: The primary aim of this article is to critically review the clinical features and comorbidities, epidemiology, pathophysiology, and treatment of impulse control disorder (ICD) associated with Parkinson disease (PD).
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She was uncommunicative and unable to follow commands.
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The treatment improved the childrens' clinical condition prior to surgery and facilitated tumor removal, resulting in partial regression of the tumor.
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Tissue distribution of olanzapine in a postmortem case.
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After the second infliximab infusion, he was found to have a severe transient neutropenia (0.5 x 10(9)/L).
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A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.
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All cases presented within the first 10 postoperative days and improved with 1 month of cessation of cyclosporin (CyA), although halting, monotonous speech was evident to some degree in all five for up to 1 year.
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We describe herein the first two cases of Plesiomonas shigelloides continuous ambulatory peritoneal dialysis-related peritonitis.
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A case report.
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Long-term prophylaxis with TMP/SMX is necessary to prevent the relapse of nocardia.
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Suddenly, the infant presented inconsolable crying, and then she appeared pale, hypothermic, and irritable.
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Guidelines for the safe use of hexoprenaline in preterm labour are suggested.
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The immediate and short-term TKI side effects are well known, but the long-term side effects have not yet been clearly identified.
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In ten cases (4.3%), radiology showed damage to the alveolar interstitium typical of inflammatory forms, whereas in the remaining three (1.3%) it depicted nodular opacities, which required differentiation between lung metastases and septic emboli.
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John's wort, in addition to several prescription medications.
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Severe histological osteomalacia developed in a woman with Crohn's disease 2 years after ileal resection and the start of cholestyramine therapy.
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Sustained hypothyroidism induced by recombinant alpha interferon in patients with chronic hepatitis C.
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Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.
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Median platelet nadir counts for all patients was 14.5 x 10(9))/L (range 1-24).
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The thrombolytic therapy, together with heparin prophylaxis, was successfully administered in the hematology ward without the need for intensive care support (i.e. mechanical ventilation).
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Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.
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METHODS AND RESULTS: Skin prick tests were positive to cloxacillin in case 1 and negative in case 2.
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A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency who developed a syringotropic hypersensitivity reaction after 9 months of therapy with infliximab and leflunomide is described.
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The nature of the process was not recognized initially, and the patient was treated with intravenous antibiotics.
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The clinical, biochemical, and pathological picture was similar to Reye's syndrome.
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We report a case of biopsy-proven BO after bone marrow transplantation in a child who, after failed corticosteroid therapy, was treated with infliximab, a monoclonal antibody with binding specificity for human tumor necrosis factor-alpha.
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A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.
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Failure to thrive is also a frequent side effect of treatment.
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Other cases have been reported in the literature, in one of which assisted ventilation was required.
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He had a permanent pacemaker inserted 4 years previously for Mobitz type II AV block detected on stress electrocardiogram, which developed 1 month after initiation of lopinavir/ritonavir.
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However, cyclosporine dependency is associated with the risk of nephrotoxicity.
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Pathognomonic signs of CIN were present.
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CONCLUSION: Our data suggest an association between cGVHD and post-HSCT MN.
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A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.
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DESIGN: Retrospective case review.
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Alertness returned over the 24 hr following by the discontinuation of BH-AC and intravenous administration of diphenylhydantoin, although she complained of intermittent headaches and visual disturbance.
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