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There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.
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Within 6 months of pranlukast withdrawal, anemia resolved and urinary sediment and renal function normalized.
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Acute erythroleukemia complicating prolonged chemotherapy for ovarian carcinoma.
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We report 2 cases of patients receiving sunitinib for metastatic renal cell carcinoma while undergoing dialysis.
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8. The leukemogenic potential in man of prolonged cytotoxic agents therapy, especially with alkylating agents, seems to be well established.
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Six months after the onset of type 1 diabetes mellitus, the patient continues to receive 40 units of insulin daily.
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The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.
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She made remarkable improvement and remains transfusion independent afterwards.
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After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.
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The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.
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The recent cloning of the FMF gene on the short arm of chromosome 16p, and the subsequent finding that its tissue expression is limited to granulocytes, has helped to explain the dramatic accumulation of neutrophils at the symptomatic serosal sites; the wild-type gene likely acts as an upregulator of an anti-inflammatory molecule or as a downregulator of a pro-inflammatory molecule.
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Three cases of unintentional overdose with simple analgesics are presented.
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Although this patient had multiple risk factors implicated in the development of invasive pulmonary aspergillosis, the infectious potential of inhaled marijuana must be recognized.
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An adolescent male developed acute pancreatitis and pseudocyst of the pancreas 16 weeks after cessation of intramuscular L-asparaginase.
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The association of CLL and acute leukemia is a rare event described in < 1% of CLL, the type of acute leukemia being either from the lymphoid or more often from the myeloid lineage.
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Awareness of this condition is important, because early recognition can prevent morbidity and lead to safe and effective treatment.
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After switching, 11 got better, 29 remained stable whereas seven got worse, according to the Global Improvement.
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Duodenal ulceration: a complication of tolazoline therapy.
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Its mode of anti-inflammatory actions in rheumatoid arthritis is not clearly understood, but modulation of neutrophil activity or inhibition of neutrophil inflammatory product formation or release appear to play a role.
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All but one patient were receiving tacrolimus monotherapy, excluding other drugs that might have been involved to cause the syndrome.
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Can magnesium sulfate therapy impact lactogenesis?
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The patient was successfully treated with intravenous pamidronate on his first admission and with hydrocortisone on the second.
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In March 1999, a 35-year-old woman had uneventful laser in situ keratomileusis in both eyes on the same day.
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The safety and tolerability profile of rFVIIa in bleeding neonates was also evaluated.
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Hepatopathy subsided after the cessation of carbamazepine and lynestrenol.
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Although the mechanism of this paradoxical phenomenon is not well understood, a defective local tissue immune response with gradually increasing maturity of the lesions during antituberculous therapy, which results in poor penetration of these drugs into the lesions, might be a possible explanation.
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A high percentage experienced good to excellent results.
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Moreover, the safety and efficacy of intracranial vertebral stenting should be further reevaluated by large-scale randomized trials.
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This study provides a review of the medical literature and presents the intralesional injection technique of 0.1% bleomycin into the wart tissue itself.
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Renal hypophosphatemia in this patient was caused by the erroneous intake of 1 g doxycycline.
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Although the movement disorder could not with certainty be attributed to trazodone alone, the drug at least acted as an eliciting agent.
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Benefit from this was limited and a course of intra-arterial urokinase was instituted.
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The prevention and treatment of de novo HBV infection after OLT is discussed.
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We describe an exceptional case of Candida tropicalis sepsis in a patient submitted to allogeneic BMT; the diagnosis was made on a peripheral blood smear, when the pt was neutropenic and only mildly febrile.
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After 12 months of treatment, molecular biology showed an important reduction in the peripheral blood of the fusion oncoprotein bcr-abl p210-b3a2.
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PURPOSE: Small-cell esophageal carcinoma (SCEC) is a rare disease for which standard therapy has not yet been established.
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She has been admitted with non-productive cough, dyspnoea and fever 11 months after the initiation of combination therapy.
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In 1996, the manufacturer began a direct-to-consumer advertising campaign, raising concerns of more exposed pregnancies.
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Histological studies confirmed the diagnosis of KS and documented its complete regression.
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Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures.
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Although high-dose methotrexate has been shown to be useful in the treatment of primary osteogenic sarcoma, the tumoricidal effects of therapy appear to have caused a fatal rise in intracranial pressure.
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Improvement in prothrombin time, activated partial thromboplastin time, and fibrinogen after rFVIIa administration was statistically significant, as compared with that observed after conventional treatment.
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We suspect that isotretinoin may complete for normal retinol binding sites on cell surfaces or transport molecules.
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She experienced cardiac arrest and died 72 hours after receiving chemotherapy.
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Extrahepatic cholestasis, viral hepatitis and autoimmune liver disorders were excluded.
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The results of these studies could also lead to significant modifications in recommendations for long-term maintenance therapy with cytotoxic agents.
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We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.
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Many new serotonergic antidepressants have been introduced over the past decade.
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This is a case report of fatal cryptococcal meningitis in a child with systemic lupus erythematosus being treated with prednisolone and azathioprine.
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PTLD appears to be different in its pathogenesis from that of PCNSL which occurs anew in the brain of these patients.
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Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.
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Oxygen potentiation of bleomycin-induced pulmonary toxicity is discussed.
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Furthermore, therapy with dantrolene has been demonstrated to be beneficial in the treatment of MH associated with diabetic coma.
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An intensive search revealed that this patient was receiving coumadin that was given by the mother.
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She was treated with fluid resuscitation, wound dressing, and antibiotics.
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Inhibition of cytochrome P450 seems to be an important mechanism.
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Ampicillin trihydrate aggravated the symptoms of two myasthenic patients.
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Calcium-channel blockers are useful for the treatment of hypertrophic cardiomyopathy (HCM), but, their adverse effects, especially, those of diltiazem, have not been of much concern.
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Best-corrected visual acuity was 20/50 O.D. and 20/60 O.S.
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At surgery, the diagnosis of focal nodular hyperplasia was established.
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We describe four patients with episodic bilateral vision impairment related exclusively to light exposure.
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However, two previous descriptions of interstitial nephritis related to treatment with TKIs, combined with this current report suggest that TKI therapy could be associated with this rare but life-threatening complication.
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Two patients developed acute cholangitis and 2 patients experienced skin phototoxicity.
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CONCLUSIONS: RPE tear is a complication that may occur following PDT in particular when the PDT is applied to an occult subfoveal CNV.
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Atypical necrotizing scleritis after strabismus surgery.
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She also had low-grade fever, intermittent chronic abdominal pain, weight loss, polyarthralgia, and conjunctivitis.
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The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.
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Putaminal infarct in methanol intoxication: case report and role of brain imaging studies.
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We used telmisartan to manage high blood pressure values in an HIV-positive patient with insulin-dependent diabetes.
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PURPOSE: To investigate the concentration-side effect relationship in a patient with severe acyclovir-induced neurotoxicity and to summarize the information available in the literature about central nervous system side effects due to acyclovir.
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Photosensitisation induced by clofazimine in a cat.
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However, the occurrence and management of akathisia induced by fluvoxamine have not been described.
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Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.
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We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.
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The temporal sequence suggests that the drug infusion initiated the lung injury.
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Clinical suspicion of ASPPC upon observation of these characteristic features is crucial for early diagnosis and treatment.
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Besides hysterectomy, the treatment options for adenomyosis have been limited.
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Treatment with high-dose intravenous IgG (HDIgG; a first-generation preparation) was ineffective, but a course of steroids resulted in a rapid increase in the the platelet count.
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Laparascopy proved useful in making the initial diagnosis, but may have contributed to the pathogenesis of the pulmonary process.
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Potential mechanisms involved in the occurrence of ischemic colitis in patients receiving tegaserod are also discussed.
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She refused surgery to remove the eye and orbital contents (exenteration), and was referred to palliative care.
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When clonazepam was reduced and discontinued, these behaviors significantly decreased from 3.1% of intervals (95% confidence band = 1.6% to 4.6%) to 0.1% of intervals (95% confidence band = 0% to 0.1%).
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Practical aspects of 3,4-diaminopyridine treatment of the Lambert-Eaton myasthenic syndrome.
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A pulmonary restrictive defect with a prominent decline of forced vital capacity (FVC) when the patient was on supine position was recorded.
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Ticlopidine-induced aplastic anemia (TIAA) is considered very uncommon.
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Prolongation of the prothrombin time owing to a transient reduction in factor VII activity is described in a 14-month-old child with organophosphate poisoning.
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Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil.
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All patients developed esophageal varices, 5 patients presented at least one bleeding episode and 2 required TIPS.
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OBJECTIVE: To describe a newly recognized adverse effect of imiquimod.
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Because treatment has focused mainly on supportive care and generally unsuccessful immunosuppression, children with BO experience significant morbidity and mortality.
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Exacerbated radiodermatitis and bilateral subdural hemorrhage after whole brain irradiation combined with epidermal growth factor receptor tyrosine kinase inhibitors for brain metastases in lung cancer.
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Akathisia appeared to be a common side effect of fluoxetine and generally responded well to treatment with the beta-adrenergic antagonist propranolol, dose reduction, or both.
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Transthoracic echocardiogram showed global hypokinesis with an ejection fraction (EF) of 5-10% prior to cardiac arrest, compared to baseline and following EF's of approximately 35%.
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Treatment of periodontal disease in a patient with Turner's syndrome.
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Systemic and topical antibiotics were administered and urgent surgical debridement and replacement of the LASIK flap was performed.
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Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature.
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Toxic epidermal necrolysis associated with interleukin-2.
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Massive subfascial hematoma after alteplase therapy for acute myocardial infarction.
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It is postulated that renal tubular damage secondary to the cumulative effects of repeated courses of aminoglycosides resulted in hypomagnesaemia, and we suggest screening for this problem by monitoring serum magnesium regularly in all patients with CF receiving multiple courses of aminoglycosides.
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Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.
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