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RESULTS: Replacing valproate with lamotrigine resulted in a decrease in serum testosterone concentrations in all 3 women.
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Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.
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Whitish papules on the palm.
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Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects.
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A case report is presented of an antenatally diagnosed fetal goiter induced by antithyroid medications.
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Numerous oral complications have been documented as a consequence of chemotherapy for the treatment of cancer.
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Addition of over-the-counter medications, herbal products, vitamins, or dietary changes was denied.
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Intravenous ganciclovir was started and continued for 3 weeks.
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L-T4 stimulated lymphocyte transformation in this patient.
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The presentation can be varied depending on severity.
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Sequential therapeutic trials with intraarterial 5-fluorouracil, intraarterial adriamycin, and intravenous 1,3 bis[2-chloroethyl]-1-nitrosourea (BCNU) were unsuccesful.
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Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate, prednisone, and asparaginase.
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This drug has been used for treatment of human malaria since 1984, and to date clinical trials have involved about 3.4 million patients in more than 30 countries (personal communication).
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A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.
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The tumor subsequently spread to involve skin of the forearm and arm.
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We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.
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A drug interaction between zafirlukast and theophylline.
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The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.
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Emergence of Philadelphia positive chronic myeloid leukaemia during treatment with hydroxyurea for Philadelphia negative essential thrombocythaemia.
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Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.
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Photodynamic therapy and intravitreal triamcinolone were used in an 84-year-old man with choroidal neovascularization in the left eye.
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Serologic HIV was negative and HHV8 viremia was under the limit of quantitation of the assay.
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CONCLUSION: These new targeted agents result in unique cutaneous toxicities.
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GCV-resistance during VCV-prophylaxis was rare after renal transplantation.
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Development of nephrotic syndrome in a patient with acute myeloblastic leukemia after treatment with macrophage-colony-stimulating factor.
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Side effects were managed by temporary discontinuation of gold until side effects resolved and resumption of treatment using usually 50% lower dosage.
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Type B lactic acidosis, a rare but often fatal disorder, has been reported in 21 AIDS patients on antiretroviral therapy (ART).
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The subsequent conditioning regimen included busulfan 16 mg/kg, Ara-C 12 g/m2 and melphalan 140 mg/m2.
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Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report.
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Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.
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This patient's ectropion and facial eczema may have been confounded by ocular rosacea.
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We studied this drug in a continuous ambulatory peritoneal dialysis (CAPD) and immunocompromised patient.
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Diagnosis of sclerosing glomerulonephritis occurred in this patient during anastrozole use, suggesting a newly defined side effect of anastrozole.
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The patient's high CMV-DNA viral load became undetectable on leflunomide and foscarnet, but the patient, who had severe graft-versus-host disease (GVHD) of the liver, expired with progressive liver failure and other complications.
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The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.
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Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding.
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We do not know why these differences occur.
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There are few aids to diagnosis but once it is known that the patient has been on practolol the surgical and pathological findings are pathognomonic.
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The morphologic findings of group 1 biopsies were those of autoimmune hepatitis in all 4 patients.
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Atypical facial pain or neuralgia and lower-half headache are confusing terms and should be discarded.
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Selective serotonin reuptake inhibitors and benzodiazepines appear to be the most common pharmacologic treatment approaches.
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First, he received salazosulphapyridine (SASP) as treatment for the UC.
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He was transfused with 3 units of packed red blood cells.
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In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity, even at lower doses, which resulted in two drug-related deaths.
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Corneal calcifications are presumably related to longer-lasting phosphate application.
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Insulin-induced lipoatrophy in type I diabetes.
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But when corticosteroid eyedrops were added, there was a recurrence of the keratitis.
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This case illustrates that distortion-product otoacoustic emissions (DPOAEs) may be an appropriate cross-check measure to supplement and confirm pediatric behavioral data.
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Subphrenic abscess secondary to Actinomycosis meyeri and Klebsiella ozaenae following laparoscopic cholecystectomy.
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Further research into the mechanism of IFN related cutaneous side effects is needed.
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A patient with complex regional pain syndrome type I of the left upper extremity was scheduled for left stellate ganglion block with the anterior paratracheal approach under fluoroscopy.
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The patient had a long history of constipation with daily use of mineral oil.
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A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.
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Clinical features suggested that the lesion was an ischemic infarct, and this was confirmed by an MRI scan.
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Patient 2, a 24-month-old girl, was asymptomatic during the first days after the accident; subsequently, she started to cough and developed fever, dyspnea and chest pain.
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Multiple syncopal episodes started to occur during thalidomide treatment, and a Holter electrocardiogram showed multiple abnormalities, with an episode of sustained ventricular tachycardia.
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Posterior leukoencephalopathy syndromes have been reported with hypertension, and immunosuppressive and chemotherapy agents.
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CBC revealed pancytopenia.
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DISCUSSION: Toxic epidermal necrolysis is an infrequent, yet often fatal, severe, systemic, cutaneous disease most often the result of an adverse drug reaction.
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Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.
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Special attention should be paid to symptoms of pulmonary thromboembolism in patients after spinal surgery.
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Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.
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METHODS: 33-year old man with bilateral nonrhegmatogenous retinal detachment, misdiagnosed as uveitis, iatrogenically treated with systemic corticosteroids.
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Acute respiratory failure precipitated by a carbonic anhydrase inhibitor.
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CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.
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Traditionally, charcoal haemoperfusion is used to remove the drug.
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A case of gouty arthritis following percutaneous radiofrequency ablation for hepatocellular carcinoma.
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Recently lamivudine has been reported to be effective in suppressing the replication of HBV under such conditions.
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Administration of cation-exchange resin such as sodium polystyrene sulphonate (Kayexalate) is effective in lowering plasma potassium, although complications following oral or rectal administration are reported in newborns.
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Pipotiazine palmitate, a long acting drug, indeed: a case report.
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Miconazole a new antifungal agent was used with dramatic response.
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There are few references of allergic reaction to this hormone.
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The patient underwent a total hysterectomy and bilateral salpingo-oophorectomy with multiple omental biopsies.
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Methotrexate may rarely provoke serositis, even with low doses and after just a few weeks of therapy.
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Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.
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Although hypophosphatemia induced by aluminum-containing antacids is rare, treatment of peptic ulcer disease with a combination of two aluminum-containing agents may increase the risk of clinically significant hypophosphatemia.
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Acute gastrointestinal bleeding following aortic valve replacement in a patient with Heyde's sindrome.
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A 52-year-old, white female developed low-grade fever, cough, and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis.
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The present report is of a 67-year-old woman presenting with bulky cervicothoracic RIF who, 10 years previously, had received radiochemotherapy for a small cell thyroid carcinoma to a dose of 50 Gy, with severe acute side-effects.
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Its pharmacological manipulation invariably impacts at multiple molecular sites.
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In all cases, seizures were controlled by withdrawal of phenytoin and reduction of drug levels.
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The administration of "sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.
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We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.
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The symptoms disappeared with clemastine and betametasone treatment.
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1 previously untreated patient with plasma-cell leukaemia and 8 patients with myeloma (4 previously untreated) were treated with high-dose melphalan 100-140 mg/m2 iv.
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She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.
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Emergent operative re-exploration confirmed these findings; large, swollen paraspinal muscles, a functioning drain, and no hematoma were found.
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One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity.
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Paradoxical ventricular tachycardia and fibrillation after intravenous bretylium therapy.
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A case of Erythema Multiforme Bullosum in patient of lepromatous leprosy with pulmonary tuberculosis due to Rifampicin is described.
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The purpose of this study was to evaluate the neuroprotective effect of MB in these patients and to review the literature.
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We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).
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Thyrotropin-producing pituitary adenoma associated with Graves' disease.
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Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia.
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Nystatin was ineffective.
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We describe two such cases manifesting at different times during the course of primary hypothyroidism.
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A mini-review of the literature based on a MEDLINE search follows.
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TMJ symptoms improved after the first bilateral intra-articular infliximab injections but even more so after the second injections.
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Drugs are a major cause of this disease, and the list of culprits is continually expanding.
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Five days after beginning continuous ambulatory peritoneal dialysis (CAPD) he developed an eosinophilic peritonitis (EP).
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