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The massively obese patients had an increased risk of cancer and complications from therapy.
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Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.
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Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.
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Temsirolimus-induced glomerulopathy.
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We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.
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We treated 21 patients with stage D prostatic adenocarcinoma who had had unsuccessful hormonal therapy with a combination of 600 mg. per M.2 per day estramustine phosphate (Estracyt) and 15 mg. per M.2 per day prednimustine (Stereocyt, Leo 1031) in daily oral doses.
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Primary spontaneous coronary artery dissection is a rare condition but one that must be considered when young people, especially post partum women, present an acute ischaemic syndrome.
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Here we describe another case of VOD occurring after LT, but in which the causative role was played by azathioprine.
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Severe methotrexate toxicity occurred in two of these patients.
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A patient with disseminated herpes zoster developed a syndrome of inappropriate antidiuretic hormone and profound hyponatremia secondary to the administration of adenine arabinoside.
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Fourteen days after discontinuation of G-CSF therapy his monocyte counts returned to normal levels and a marrow aspirate showed a reduction in blast cells.
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Fatal intracerebral hemorrhage during dental treatment.
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The clinical and hemodynamic characteristics of the patients were as follows.
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Drug induced myopia associated with treatment for gynecological problems.
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Psychosis was stable with flupentixol monotherapy.
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BACKGROUND: Interferon beta has become standard therapy for reducing relapse frequency in relapsing/remitting Multiple Sclerosis (RRMS).
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Further work-up led to the diagnosis of anterior spinal artery syndrome.
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An objective causality assessment indicated a probable relationship between clotting abnormality and warfarin administration, although the degree of elevation of the INR was unusual in the light of the daily warfarin dose and duration of its exposure.
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During a period of 4 years, the boy was examined six times with electroretinography.
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Because of its favorable tolerability profile it appears to be a preferred alternative, especially in NSAID-sensitive patients.
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The main outcome measured was intraocular pressure (IOP) in mm Hg.
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It seems that trigeminal manipulation during dental treatment as well as increased serum levels of induced epinephrine mainly by stress and pain, and the small amounts absorbed from the site of local anesthesia might produce abrupt elevation of blood pressure, subsequent increase in cerebral blood flow and severe, even fatal intracerebral hemorrhage.
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Philadelphia chromosome-positive acute lymphoblastic leukemia secondary to chemoradiotherapy for Ewing sarcoma.
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She was induced into CR by ALL-directed chemotherapy and then maintained with IFN-alpha2b together with weekly rotational chemotherapy.
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Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as "retinoic acid syndrome." This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.
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However, 4 days later the ocular pressure of the first patient increased to 22 mmHg, which led to suspension of the drug.
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Inhibitory effects of various drugs on dual asthmatic responses in wheat flour-sensitive subjects.
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Hemorrhagic stroke following elective cesarean delivery.
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CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections are the major side effects of fludarabine phosphate therapy.
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The in vitro susceptibility assay showed that the clinical isolate was resistant to foscarnet, moderately resistant to ganciclovir, but sensitive to cidofovir.
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Bromocriptine-induced schizophrenia.
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A case is reported in which posterior synechiae to the manufacturer's trademark on the surface of a Shearing intraocular lens were noted ten days after the implantation of the lens.
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BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.
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Autopsy revealed no pathologic findings in the heart or in the extra- or intracranial arteries.
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No change in thrombus size was seen on a followup echocardiogram after 4 days.
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Chronic viral infection relapsed after the suspension of the IFN-alpha therapy.
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The second had acute cystitis and was treated by sulphonamide and the third developed myopia coincident with metronidazole treatment for trichomonas vaginalis.
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The interaction of these factors are analyzed in this report.
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The boy is now 14 months off tuberculostatic treatment and 8 months off AML therapy.
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These re-calculations revealed unexpectedly high doses in the range 79 to 82 Gy (cumulative external and brachytherapy dose) at the level of the optic nerves, which explained the observed radiation injury.
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Normalisation of phenytoin levels was associated with return of euthyroidism.
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We report the use of pamidronate for acute, severe hypercalcemia secondary to iatrogenic vitamin D poisoning.
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Additionally, clinically effective doses of conventional antipsychotics can actually aggravate negative symptoms through the development of extrapyramidal symptoms (EPS).
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Patients treated with L-asparaginase may present with hemorrhagic and thrombotic cerebrovascular events.
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Their attenuation density values were appreciably less than that of calcium and they enhanced slightly with contrast.
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We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects.
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The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.
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CONCLUSION: All doctors need to be aware of the need to review the indications for gabapentin use during periods of acute illness, especially with regard to renal impairment.
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The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment.
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We conclude that vincristine and actinomycin D were the cause of this rare from of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.
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A case of cataract development in a patient with atopic dermatitis is presented.
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(3) A 61-year-old woman with active refractory Wegener's granulomatosis who developed respiratory insufficiency due to aspergillus and pseudomonas pneumonia.
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To our knowledge, this is the first such description of this phenomenon in the literature.
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A case is presented, in which the extrapyramidal side effects of depot pipotiazine lasted well over 6 months, and possibly the therapeutic effect for almost 12 months following the last injection.
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This patient may have been at increased risk for this interaction secondary to his age and history of alcohol abuse.
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Decompression sickness and arterial air embolism which follow exposure to raised environmental pressures of compressed air are usually adequately treated by accepted recompression procedures of relatively short durations.
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Although this can be coincidental, it can also suggest that the basis of a thrombus may dissolve first with any, including oral, anticoagulation.
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In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.
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All abnormalities were transient, with recovery a few days after foscarnet withdrawal.
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The patient's headache resolved with diltiazem therapy and she was able to complete capecitabine and radiation therapy without further adverse events.
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Maximum improvement may not be reached before 8 weeks.
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The affected interlobular artery included concentric intimal thickening and thrombosis in the lumen.
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Development of essential thrombocythemia in a patient treated with interferon alfa and pentostatin for hairy cell leukemia.
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CASE REPORT: We describe here a case of a 60 year old female that experienced a relapse of symptomatic hyperlactatemia after being switched from stavudine to zidovudine and how the case was managed at the Infectious Diseases Institute, Kampala, Uganda.
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Death occurred 4 to 16 weeks later.
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DISCUSSION: Phenolphthalein is the active ingredient in several over-the-counter laxative preparations and has only rarely been reported to cause TEN.
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There was no reaction to the antibiotics.
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These mutations were not present in samples obtained during the primary CMV infection.
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Macrodantin: a cautionary tale.
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We describe the effect of multiple cycles of 5-fluorouracil administration in a patient receiving warfarin therapy.
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Three children completely recovered; one patient relapsed and died.
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This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.
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A 21-year-old woman presented with a 1-month history of whitish bubbling of the palms after brief exposure to water.
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Many past cases of SMON have occurred in Japan but since 1975 no new cases have been reported.
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A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.
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An emergency tracheostomy was life saving.
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A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.
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Report of a case.
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The mare subsequently delivered a healthy foal.
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Parents were thoroughly questioned but we could not find out a new traumatic head event.
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Clinic records were reviewed to extract clinical and laboratory data.
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A 35-year-old woman presented with neurotoxicity correlated to an i.v. regimen of 5-fluorouracil as episodes of acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum.
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Metabolic acidosis induced by cetrimide-chlorhexidine solution in hydatid cyst surgery.
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Hypertonic sodium bicarbonate is recognized as effective therapy for hypotension and arrhythmias.
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Over the last five years three new classes have been released.
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Based on this report and previous case reports, caution is advised when concurrent warfarin and 5-fluorouracil are prescribed.
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Two patients with Parkinson's disease with pedunculopontine nucleus (PPN) stimulation for gait impairments reported "trembling vision" during the setting of the electrical parameters, although there was no clinically observable abnormal eye movement.
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Efficacy, cost, toxicity, and duration of treatment determine a treatment protocol.
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All patients were in a group with an expected mortality rate of 90-100%, based on previous studies.
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Three patients (APML = 1 and ALL = 2) are still alive and disease-free.
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Anti-platelet therapy with clopidogrel has been shown to reduce both acute and chronic events in patients with NSTE ACS, including patients undergoing PCI.
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Uveitis associated with rifabutin therapy: a clinical alert.
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Herein, we report a patient treated preoperatively with multiple psychiatric medications who developed serotonin syndrome (SS) during the perioperative period.
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The average length of clinical follow-up was 6 months (range 1-13 months).
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In this group, four men were seen with osteonecrosis.
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Pseudomembranous colitis readily occurs in at least certain population groups receiving trimethoprim-sulfamethoxazole.
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Mitomycin C-related hemolytic uremic syndrome in cancer patients.
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We suggest that nicotinic acid was the cause of his liver disease, that this case is of particular note because of the rather short period of therapy before the onset of liver injury and the severity of the hepatic failure, and that the probable increased use of nicotinic acid for serum cholesterol control makes it especially important for physicians and their patients to be alert to the signs of hepatotoxicity.
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Side effects such as acute renal failure, hyperkalemia, gastritis, gastrointestinal bleeding, and asthmatic exacerbation, although rare, have been previously reported.
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Laboratory data showed hypernatremia with increased plasma osmolality and metabolic hyperchloremic acidosis.
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