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We describe a patient in whom noncardiogenic pulmonary edema developed during intrabiliary infusion of monooctanoin.
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Starting with the 8th hospital day, the thrombocyte count steadily increased from 410000/microl to a maximum of 1132000/microl on hospital day 16.
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Despite spontaneous revascularization of many of the lesions, subchrondral collapse caused symptomatic secondary degenerative arthritis in many joints.
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We report a case of fatal C. neoformans fungemia in a neutropenic patient with a history of chronic lymphocytic leukemia treated with alemtuzumab.
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The means whereby this agent might injure oseophageal mucosa are discussed.
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Although the patient had no symptoms 10 hours after intrathecal treatment, to prevent the possible neurotoxic effects of methotrexate, a cerebrospinal fluid exchange was performed.
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Two attempts at carboplatin desensitization were unsuccessful.
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The use of high potency topical steroids for the treatment of oral vesiculoerosive diseases seems to have been a contributing factor in two of these cases.
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Clinical use of oral contraceptives administered vaginally: a case report.
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Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.
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Pneumatosis intestinalis associated with immune-suppressive agents in a case of minimal change disease.
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It has been approved by the Food and Drug Administration for 24-h use.
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Two fatal cases of poisoning by paracetamol are described.
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A 2-month course of sucralfate and cimetidine was used and successfully produced symptomatic relief as well as complete normalization of the dysplastic changes.
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All seven patients who were given an oral formulation of cyclosporine tolerated it well after a reaction to the intravenous infusion.
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Hypokalemic sensory overstimulation.
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This article presents a case of an atypical localized cutaneous eruption with an unusual course and protracted resolution time associated with sorafenib therapy.
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These findings are consistent with recent in vitro literature, which implicate a series of neuroleptic medications with mitochondrial dysfunction.
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One month after cataract surgery in the right eye, the best-corrected visual acuity was right 6/6 (-1.25) and left 6/10 (-2.00/-0.50 x 100).
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Six weeks after admission, abscess material was grown on Mycoplasma culture medium yielding U. urealyticum in high titres.
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A 35-year-old woman presented with neurotoxicity correlated to an i.v. regimen of 5-fluorouracil as episodes of acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum.
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Granular parakeratosis.
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CNS angiitis in graft vs host disease.
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Such cases could prove an interesting locus for the investigation of both affective disorders and tardive dyskinesias.
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Patients with metastatic disease to the bone marrow are at risk of significant hematologic toxicity, if they undergo myelotoxic chemotherapy.
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Two patients received no further anticoagulation, and two received continuous heparin within 24 hr of implant to maintain activated clotting times of 140-150 sec.
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In this case report, we have described a patient with Crohn's disease who developed subfulminant hepatitis B after the fourth infusion of infliximab due to an unrecognized HBs-antigen carrier state.
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Monocomponent porcine insulin was injected into each quadrant of the pit.
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Although they had complex medical problems, the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy.
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In this complicated patient, who was resistant to oral warfarin and unable to receive subcutaneous low-molecular-weight heparin, therapeutic anticoagulation was achieved with intravenous warfarin.
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Danazol induced thrombocytopenia.
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In the present paper, we report four very elderly patients (80 years of age or older) with primary nephrotic syndrome.
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With the increasing use of Cyclosporine A in transplant patients, the incidence of herpes esophagitis may increase.
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Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.
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Amiodarone, a class III antiarrhythmic drug, is one of the most effective drugs used in the treatment of ventricular and paroxysmal supraventricular tachyarrhythmia.
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Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels.
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Azathioprine (AZA) is an immunosuppressant commonly used for organ transplantation and autoimmune diseases.
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This article is a guide to its usage in children and includes discussion of its indications, contraindications, pre-treatment laboratory studies, dosing and drug interactions.
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The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.
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A patient with acute esophageal variceal bleeding developed fatal rhabdomyolysis during treatment with a continuous intravenous infusion of vasopressin.
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Dissemination occurred under voriconazole.
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A second case involves a 21-year-old woman who substituted generic carbamazepine because of financial problems.
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These side effects include agranulocytosis, seizures, and cardiorespiratory symptoms.
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Although lymphomas are known to emerge in the setting of immunosuppressive therapy, it has not been well described or established for the newer biologic immune response modifiers.
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CONCLUSIONS: Intravenous therapy with the anti-CD20 antibody rituximab is a nontoxic and effective treatment for patients with primary cutaneous B-cell lymphoma.
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She achieved complete remission, but one year later had a relapse in her external auditory canal without leukemic cell in the bone marrow.
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In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.
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Despite an elevated "endogenous" Epo level, a greater than 1.5 g/dl increase in hemoglobin (Hb) concentration was observed in one patient with refractory anemia (RA), one patient with refractory anemia with excess of blasts (RAEB), and one patient with AA.
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Auditory damage may be reduced by changes in dose, drugs or methods of treatment.
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Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus.
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Although systemic nocardial infections traditionally have had a grave prognosis, through early diagnosis, surgical intervention, and the use of newer, safer and synergistically acting antimicrobials, the prognosis has improved.
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Biopsies of the iliac crest demonstrated the presence of severe osteomalacia and massive deposition of aluminum in the bone.
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After processing to reduce its toxicity, 'maqianzi' was used as a herbal remedy for rheumatism, musculoskeletal injuries and limb paralysis.
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Progressive pulmonary fibrosis complicating cyclophosphamide therapy.
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A magnetic resonance imaging scan obtained 7 weeks after the injection showed a full-thickness tear of the supraspinatus tendon.
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We report here a rare case of pleuropericarditis due to methotrexate.
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An additional feature peculiar to these 2 cases was the presence of unexplained extramedullary hematopoiesis.
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Also, we have reviewed selected features in eight patients who took overdoses of chloral hydrate who were admitted to an intensive care unit between 1981 and 1988.
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Six amino acid mutations were located in the 'a' determinant, including P120T, K122R, M133T, F134L, D144A and G145A.
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Light microscopy of a renal needle biopsy specimen showed interstitial lymphoid cell infiltration, but no marked changes of the glomeruli and no staining for immunoglobulin or complement.
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Marked improvement of psoriasis or arthropathy occurred in each case without side effects.
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It causes transient atrioventricular nodal block and thus ends paroxysmal supraventricular tachycardias that involve the atrioventricular node.
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Neurologic examination and brain magnetic resonance imaging (MRI) were normal, but interictal EEG showed left frontal epileptiform activity.
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Immediate diagnosis and treatment of the perforated appendicitis saved the life of the patient.
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Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment.
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We suggest that the sagittal sinus thrombosis in this patient was caused by acquired, transient free protein S deficiency.
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Cerebral toxoplasmosis - a late complication of allogeneic haematopoietic stem cell transplantation.
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Ifosfamide-associated neurotoxicity was noted within hours of drug administration and improved rapidly following hemodialysis.
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Blood sugar and A1c were finally stabilized one month after discontinuation of olanzapine (A1c,6.9%).
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Acute renal failure due to crystal deposition in the urinary tract was well described 30 to 40 years ago and is likely to resurface as a clinical entity if appropriate prophylactic measures are not taken.
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Its use in reproductive age women has become increasingly common in recent years, intensifying the risk of fetal exposure.
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MAIN OUTCOME MEASURES: Clinical signs and symptoms of ITB withdrawal of varying severity were assessed by vital signs (temperature, heart rate), physical examination (reflexes, tone, clonus), and patient report of symptoms (itching, nausea, headache, malaise).
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Review of the literature revealed 34 patients received chemotherapy and radiotherapy, 32 patients received chemotherapy alone, 1 patient had only surgery, and the radiation status of the remaining patient is unclear.
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CONCLUSION: A woman receiving enoxaparin every 12 hours developed signs and symptoms of hepatotoxicity after the second dose.
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These cases underscore the importance of careful examination of the retinal periphery before management of any presumed optic neuropathy with steroids.
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However, the proteinuria apparently became worse.
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The onset of symptoms after fluorescence in both cases is highly suggestive, although the pathogenetic mechanism is not clear.
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Risperidone is a frequently used member of a new class of atypical antipsychotics-the serotonin-dopamine antagonists (SDAs)-due to its comparatively high efficacy and low D2/5HT2 binding ratio, which results in a low incidence of extrapyramidal side effects including tardive dyskinesia (TD).
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Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?
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We describe a case of PRES in a patient with collapsing focal glomeruloesclerosis (collapsing FGS) with complete recovery after withdrawal of cyclosporine (CSA).
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However, during the treatment, he developed a pulmonary embolism.
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Close monitoring for toxicity and dosage manipulations might be required if such therapy is attempted.
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No other recognized causes of rhabdomyolysis were identified on retrospective review of the hospital course.
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The isolation of Kluyvera as a pathogen in transplant patients emphasizes that this commensal organism may be virulent in this patient population.
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As this was not seen in patients without Down's syndrome, we postulate that patients with trisomy 21 have bone marrow which is "at risk" for suppression, and, thus warrant close evaluation while on such medications.
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Report of four cases and comparison with autoimmune hepatitis.
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Chronic irritation of the gastric antral mucosa led to ulceration and formation of hyperplastic polyps.
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CONCLUSION: WE and thiamine deficiency should be considered in all patients with malabsorption, malnutrition, and malignancies.
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Although great advances have been made in the pharmacotherapy of schizophrenia, many patients are still not taking full advantage of the beneficial effects of antipsychotic drugs.
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One half hour following the ingestion of a possibly tainted antibiotic capsule, a 14 year-old female experienced acute onset of stiffness and weakness in her lower extremities.
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The extra care required may negate the financial advantages of the substitution.
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However, cough mixtures are a readily available source of opioids.
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Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.
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To our knowledge, this paper is the first to describe long-term experiences with patient reporting as part of a spontaneous reporting system.
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The failed graft obtained during the additional PKP was subjected to PCR analysis and histopathological examination.
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Clinicians and patients should be made aware of this possible complication of topical bimatoprost therapy.
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Future investigations evaluating the efficacy of adjunctive antibiotics for purulent SSTIs and monitoring the incidence of SJS/TEN in the era of CA-MRSA are necessary to reduce unnecessary use of sulfonamide drugs.
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Gynecomastia associated with theophylline.
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We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.
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Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis.
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