id
int64 0
4.51M
| text
stringlengths 1
10.1k
| doc_id
stringlengths 2
9
|
|---|---|---|
4,507,100 | Anti-photobleaching flower-like microgels as optical nanobiosensors with high selectivity at physiological conditions for continuous glucose monitoring. Optical glucose detection holds considerable promise for continuous in vivo glucose monitoring with wireless transdermal transmission and long-lasting activity. To construct a new class of optical glucose nanobiosensors with high sensitivity and selectivity at physiological conditions, the first generation of fluorescent poly(amido amine) (G1.0 PAMAM), serving as the optical code, was introduced into glucose-sensitive poly(N-isopropylacrylamide-(2-dimethylamino)ethyl methacrylate-3-acrylamidephenylboronic acid) copolymer microgels via a facile method. The fabricated microgels display the ability of adapting to the surrounding medium of different glucose concentrations over a clinically relevant range (0-20 mM) and convert biochemical signals into optical signals. As nanobiosensors, the G1.0 PAMAM functionalized microgels exhibit high selectivity for glucose over various kinds of potential primary interferents, such as lactate, human serum albumin and metal ions, in the physiologically important glucose concentration range. Compared to traditional fluorescent dyes and quantum dots, which are limited by photobleaching and toxicity, this microgel with remarkable anti-photobleaching property and low toxicity makes it possible to be used for long-term continuous glucose monitoring. Through in vivo investigations, it can be observed that G1.0 PAMAM functionalized microgels can achieve wireless transdermal detection, indicating that the fabricated microgels have potential applications as a new generation of nanobiosensors for the highly sensitive and minimally invasive continuous glucose monitoring. | 96979571 |
4,507,101 | Technique of wide transmission lines for reducing the impedance of S2 laser head in discharge We select the alloy and glass which match each other in expansion coefficient, which can prevent the corrosive sulfur vapor to make the electrodes and the tube wall, making the transverse discharge electrodes pass through the well sealed tube wall by technique of glass-to-metal high vacuum sealing under the condition of high temperature. The S2 discharge tube of wide transmission lines has been made. The inductance is reduced to 3% and the resistance to 28% compared with existent S2 discharge tube of single- axle transmission lines in the transmission lines. | 121301271 |
4,507,102 | Design Mix Formulation and Optimization of Metakaolin Based Alkali Activated Geopolymer Concrete with the Taguchi Method Concrete mix formulation is the science of deciding relative proportions of ingredients of concrete, to achieve desired properties in the most economical way. Formulation of concrete mix requires adequate knowledge of the properties of its constituents. Aluminosilicate materials have recently found applications in construction industry due to their unique and flexible properties. The metakaolin used for this study was the locally sourced kaolin calcined at 750oC. The alkali activating reagents include a fixed concentration of sodium silicate solution and sodium hydroxide solutions of three different concentrations. Strength development of metakaolin – based geopolymer concrete is quite different from that of ordinary Portland cement concrete due to differences in their constituents, hence, the need for special formulation, most especially when high strength is required. Taguchi method was adopted in this study to formulate mix proportion for high compressive strength of geopolymer concrete at ambient curing condition. Four parameters were selected that are more likely to influence the compressive strength of metakaolin – based geopolymer concrete, these include aggregate content, alkali – binder ratio, alkali reagent ratio and alkali reagent concentration. The effect of these parameters on the density, workability and compressive strength at 3, 7 and 28 days are determined. The result showed that an optimum mix obtained from a formulation formula (2.75SiO2 * Al2O3 * 0.55Na2O * 6.8H2O) produced a compressive strength of 62MPa at 28 days of open air curing. It was revealed that the molar concentration of the | 236764161 |
4,507,103 | alkali reagent (sodium hydroxide) should be kept within 10M range for an open air curing, the alkali reagents to binder ratio should be kept at 0.7 or less with no addition of water to achieve reasonable workability. Also, it has been observed that the bulk density of metakaolin – based geopolymer concrete that yielded substantial strength fall within 2250kg/m3 and 2350 kg/m3. | 236764161 |
4,507,104 | Recent Progress on Optical Frequency Conversion in Nonlinear Metasurfaces and Nanophotonics Frequency conversions, such as second harmonic generation (SHG), third harmonic generation (THG), high harmonic generation (HHG), and wave mixing, are typical processes in nonlinear optics, which have a wide range of applications in new light sources, bioimaging and sensing, quantum optics, and holography. To engineer and manipulate these nonlinear optical processes, metasurfaces and nanophotonic structures have been introduced, which have been successfully demonstrated as powerful tools to tailor the key features of light and excite the extraordinary phenomena in linear optics. In this review, we highlight the recent progress on frequency conversion in plasmonic metasurfaces, all-dielectric metasurfaces as well as other nanophotonic structures, ranging from SHG, THG to HHG and wave mixing. The origin of optical nonlinearity and its coupling with subwavelength resonators are discussed, which fundamentally determine the conversion efficiency and functionality. Finally, we summarize the challenges that nonlinear metasurfaces and nanophotonics now face and offer an outlook on further development and application potential. | 246989061 |
4,507,105 | Theory of Surface Ordering on Solutions of Rigid-Rod-Like Molecules This paper discusses the surface ordering and the adsorption phenomena of solutions of rigid-rod-like molecules. Here the focus on the planar adsorption of the rigid-rod-like molecules. We find that, for the attractive wall which preferentially adsorbs the rodlike molecules, the surface phase has two phase transitions when the bulk concentration is increased: One transition occurs when the adsorption amount jumps at a concentration O c where the surface phase changes from an isotropic to a nematic state while the bulk is still in an isotropic state. The other occurs when the adsorption isotherms have a kink at the bulk critical concentration O IN where the bulk phase changes from an isotropic to a nematic state. For the bulk concentration O c O IN ), both bulk and the surface phases are in isotropic (nematic) states. For various values of the axial ratio of the rigid-rod-like molecules and adsorption energy, we examine the adsorption isotherms, the surface tensions, and the surface phase transitions. We also discuss the surface transitions on repulsive walls | 95197111 |
4,507,106 | M3V: Multi-modal Multi-view Context Embedding for Repair Operator Prediction We address the problem of finding context embeddings for faulty locations to allow a learning-based APR tool to learn and predict the repair operators used at the faulty locations. We introduce M3V, a new multi-modal multi-view context embedding approach, which represents the context of a faulty location in two modalities: (1) texts that capture its signature in a natural language using the tree-LSTM model, and (2) graphs that capture its structure with two views, data and control dependences, using the GNN model. We then fuse these two modalities to learn a probabilistic classifier from correct code that, once given a faulty location, will produce a probabilistic distribution over a set of repair operators. We have evaluated M3V against the state-of-the-art context embedding approaches in repairing two common types of bugs in Java, null pointer exceptions (NPE) and index out of bounds (OOB). Trained and tested with 75673 code samples from 20 real-world projects, a learning-based APR tool can predict repair operators more effectively with our context embeddings in repairing NPE bugs, by achieving higher accuracies (11% – 41%) and higher F1 scores (16% – 143%). For OOB bugs, these improvements are 9% – 30% and 15% – 79%, respectively. | 247795611 |
4,507,107 | An Improved CPW-Fed Printed UWB Antenna With Controllable Band-notched Functions A newly designed printed slot antenna is presented that incorporates variable two band-notched functions for ultra-wideband (UWB) applications. The two band notches of this coplanar waveguide (CPW) fed antenna are achieved by an M-shaped slot (MSS) embedded in the radiating element and a C-shaped strip (CSS) close to ground plane, therefore two very narrow rejected properties in the wireless local area network (WLAN) band (5.15-5.825 GHz) and worldwide interoperability for microwave access (WiMAX) operation in the (3.3-3.7GHz) are obtained. The rectangular aperture is etched in the square ground plane. It has a determinative role in antenna’s impedance bandwidth (IBW) enhancement; moreover, by adjusting carefully it leads to wide IBW. Based on simulated results it covers the frequency range 2.4–12.9 GHz with VSWR ≤ 2, which corresponds to a fractional bandwidth of 137% excluding the rejected bands. Numerical and measured results are presented to understand its behavior. The volume of the proposed antenna is 25 × 25 × 0.8 mm3. | 13668611 |
4,507,108 | Clinical Factors Associated with Intracranial Complications after Pediatric Traumatic Head Injury: An Observational Study of Children Submitted to a Neurosurgical Referral Unit Background: Clinically validated guidelines for the management of head injury in children do not exist, and the treatment is often based upon adult management routines. In order to examine the safety of this procedure, an analysis of clinical factors associated with complications after pediatric head injury was attempted. Method: We performed a descriptive retrospective study, including patients who received any S06 diagnosis during treatment in the Neurointensive Care Unit at Lund University Hospital between 2002 and 2007. One hundred children were included during the 6 years. Results: During 6 years, 100 children with head injury needed neurointensive care or neurosurgery for their injury in southern Sweden. Traffic accidents (50%) were the main cause of head trauma, followed by falls (36%). Thirty-two percent of all children were injured in bicycle and motorcycle accidents. Both loss of consciousness and amnesia were absent in 23% of the children with intracranial injury. Seven children with intracranial injury, 6 of them requiring neurosurgery, were classed as having minimal head injury according to the Head Injury Severity Scale (HISS). Interesting differences in intracranial injuries between helmet users and nonusers were observed. Conclusion: Children with minimal head injuries (according to HISS) may develop intracranial complications and may even require neurosurgical intervention. Hence, the HISS classification, as well as other risk classifications based upon unconsciousness and amnesia, are unreliable in children. | 13156711 |
4,507,109 | [Hepatitis B virus-mediated effects on host expression of the proprotein convertase Furin]. OBJECTIVE To study the effects of hepatitis B virus (HBV) infection on the expression of Furin, an important proprotein convertase, in liver cells to provide insights towards its potential as a therapeutic target for improved antiviral efficacy. METHODS Furin expression was measured in human liver specimens (infected tissues from patients with chronic HBV hepatitis vs. normal tissues from healthy donors) and in hepatoma cell lines (HBV-infected HepG2.2.15 cells vs. uninfected parental cell lines HepG2) using quantitative real-time RT-PCR (for mRNA), western blotting and immunohistochemistry (for protein). RESULTS Compared to the uninfected tissues and cells, the HBV-infected tissue and cells showed down-regulated expression of furin at both the mRNA and protein levels. In particular, the HepG2.2.15 cells showed -50% less furin mRNA expression than the HepG2 cells and the difference was statistically significant (P less than 0.05). CONCLUSION HBV may suppress the host cell's expression of furin, possibly to benefit its survival and replication in the host cell. | 43607851 |
4,507,110 | Historical and Cultural Narratives: Confessions of a Diaspora Jew This article blends a complexity sensibility with narrative theory and especially Freeman’s notion of the narrative unconscious to bring into view our historical cultural situatedness and its influence on personal and psychoanalytic identity. Special attention is paid to trauma informed historical narratives that drastically reduce complexity and resort to simplistic and binary distinctions. Drawing from autobiographical memories, the author brings a dialogic interpretive lens to his own historical cultural narrative passed down to him as a postwar Diaspora Jew. We come to see that this narrative is soaked with the trauma of the Holocaust, creating a rigid narrative that ignores complexity, reduces the other to debasing stereotypes, and is closed off to dialogue. The author continues with his lifelong dialogic struggle to transform and maintain a historical cultural narrative that is more complex, more humane, and embodies a deep respect and responsibility for the other, a transformation inseparable from his psychoanalytic growth. The author concludes with a clinical vignette that serves as a sober reminder that the wounds of historical cultural trauma run very deep and that the narratives they spawn are never totally transformed. They remain an underground presence as slumbering ghosts, ready to surface at those moments when we feel frightened or vulnerable. | 143171201 |
4,507,111 | Biochemical and Genetic Evidence for Phospholipase C Activity in Mycobacterium ulcerans ABSTRACT This study reports the existence of phospholipase C and D enzymatic activities in Mycobacterium ulcerans cultures as determined by use of thin-layer chromatography to detect diglycerides in hydrolysates of radiolabeled phosphatidylcholine. M. ulcerans DNA sequences homologous to the genes encoding phospholipase C in Mycobacterium tuberculosis andPseudomonas aeruginosa were identified by sequence analysis and DNA-DNA hybridization. Whether or not the phospholipase C and D enzymes of M. ulcerans plays a role in the pathogenesis of the disease needs further investigation. | 97301 |
4,507,112 | Genetic Analysis Workshop 16: introduction to workshop summaries Genetic Analysis Workshop 16 (GAW16) was held on September 17–20, 2008 in St. Louis, Missouri. The focus of GAW16 was on methods and challenges in analysis of single‐nucleotide polymorphism data from genome‐wide scans. GAW16 attracted 221 participants from 12 countries. The 168 contributions were organized into 17 discussion groups of 6–17 papers each. Three data sets were available for analysis. Two of these were data from ongoing studies, generously provided by the investigators. The North American Rheumatoid Arthritis Consortium provided case‐control data on rheumatoid arthritis, and the Framingham Heart Study (FHS) made available information on cardiovascular risk factors for participants in three generations of pedigree data. The third data set included simulated phenotypes for participants in the FHS, using actual pedigree structures and genotypes. This volume includes a paper for each of the 17 discussion groups, summarizing their main findings. Genet. Epidemiol. 33 (Suppl. 1):S1–S7, 2009. © 2009 Wiley‐Liss, Inc. | 5360801 |
4,507,113 | [About the sexual hygiene of mental retarded boys, an exercise of the sexual pedagogic (author's transl)]. The sexual hygiene of mental retarded boys is examinated. In comparison with normal school boys is pointed out the necessity of sexual pedagogic education. The striking more numerous quote of balanitis in mental retarded boys is discussed with a critical review of Literature about the cleanness of the hands while miction of man, about the cleanness of the inferior abdomen, the cleanness of the pants and the hygiene of the toilet. The conclusion is drawn, that the cleaning of the foreskin has also to be observed by the mental retarded men, boys once a week and youths day by day. | 38111851 |
4,507,114 | Human-Agent interaction in the light of ontology sharing and large scale cooperation The htmlButler project aims at enhancing the human-agent interaction via the visual wrapper technology while preserving versatility. htmlButler will allow to an untrained user who has only the most basic Web knowledge to visually specify simple but useful wrappers and to a more techsavvy user to visually or otherwise specify more complex wrappers. htmlButler was started 2005/2 and is based on visual wrapping technology research carried out in the Lixto project since 2000. What is new in htmlButler is (a) that the application is entirely server based, the user accessing it through his or her standard browser, (b) that, because of the centralized wrapper configuration and processing, the knowledge about popular wrappers can be leveraged to facilitate the specification of wrappers for new users, and (c) that users can contribute narrow and precise ontologies that help the system in recognizing potential meaning in Web pages, thereby alleviating the complexity of future wrapper configurations | 14300901 |
4,507,115 | Transit Agency Strategies that Encourage Mixed Uses aroundStations Transit-oriented development (TOD) is a mixed-use residential or commercial area designed to maximize access to public transportation that often incorporates features to encourage transit ridership. Varied interests must be represented to implement TOD. Developers present concepts and financial backing, governments create guidelines or zoning that facilitates TOD, community stakeholders voice desires about their neighborhoods and transit agencies implement the transit improvement that serves as the initial catalyst. This research focuses specifically on the role of the transit agency in encouraging development proximate to transit and investigates selected transit authorities within the United States to determine what strategies and steps they are taking to facilitate proximate desirable development around their stations. | 107017651 |
4,507,116 | Pathology: a historical opportunity. The birth of the discipline of pathology in the modern conception of the term took place in Renaissance Italy. As Perez-Tamayo pointed out in his evocative biography of the "ten giants" of pathology,1 the beginning of pathology coincided with that of the most memorable cultural revolution in Western civilization. It was then and there that physicians began systematically to perform autopsies on the patients they had treated and to incorporate the results into the "final summary" they dutifully submitted to the patient's relatives. Thus, Bernardo Torni, a Florentine physician, wrote in or around 1490 to one of his illustrious patrons:2 "Magnificient Praetor: suffer from your misfortunes. It is sad indeed to lose your progeny, especially from a disease not yet clearly understood by physicians. However, believe that my having examined his organs at autopsy will be of great benefit to your other sons. Therefore, will now describe to you, as briefly as possible, our findings and conclusions, and will not hesitate to suggest some | 531701 |
4,507,117 | Spenser and Race: An Introduction ulture is not politically neutral. This is particularly true of the culture of the early modern period in which politics is engaged through poetic production. One need not be committed to the study of literature as a political project to recognize that poetry and culture are inherently political. David Norbrook suggested some time ago, “Certainly one should not deny the distinctions between poetry and other forms of discourse. But in the Renaissance these distinctions were by no means as absolute as they become in Romantic theory. . . . The issue is not so much why one should politicize poetry as why critics have for so long been trying to depoliticize it.” Edmund Spenser was invested in the use of poetry as a vehicle for the transmission of political ideas. His politics were deeply embedded in the English colonial project, and we have both argued elsewhere, “the politics and economics that ultimately produced settler colonialism, chattel slavery, the forced migration of peoples, and the development of the British empire animate . . . early English texts.” Spenser’s poetry and politics have different afterlives, and the ideologies that pass through his works adhere to us today. Our bodies themselves signify according to cultural history; understanding what and how they signify requires attending to the histories that have been overlaid on them.When we transmit the terms and relations that produced these histories, we are not simply failing to unravel them, we are, to some extent, reproducing them. Over the past thirty years, early | 233029451 |
4,507,118 | modern studies has been increasingly interested in the emergence of race as a category of identity, one that could variously demarcate groups of people along lines of lineage, nationality, | 233029451 |
4,507,119 | Children's Knowledge, Anticipatory Anxiety, Procedural Distress, and Recall of Esophagogastroduodenoscopy Background This study evaluates the relations among children's knowledge of esophagogastroduodenoscopy (EGD) and anticipatory anxiety, procedural distress, and the nature of postprocedural recall and evaluations. Methods One hundred patients, aged 8 to 17 years, completed self-report measures of knowledge and anxiety before EGD. Parents completed a self-report measure assessing how they prepared their children. Nurses and trained observers completed observational ratings of distress. Children's recall and evaluation of the procedure were assessed by self-report 1 hour after the procedure and by telephone that evening. Results Most children knew about the major components of EGD. Children with greater knowledge experienced less distress and reported that they would be less anxious and upset when undergoing future EGDs. Children with greater anticipatory anxiety exhibited more procedural distress. Children's distress varied by the phase of the procedure. Children who were more distressed during intravenous line insertion experienced greater distress during esophageal intubation and the endoscopic examination. Approximately 20% of patients reported at least some memory of the procedure even at the end of the day. Children with greater recall reported greater aversion and a more negative attitude toward future EGDs. Conclusions This study provides information about children's distress during EGD and the effects of conscious sedation on patients' memories and attitudes toward future procedures. The study indicates that preparation before EGD may reduce patient distress. | 22359201 |
4,507,120 | Product Market Uniqueness, Organizational Form and Stock Market Valuations We introduce a new framework for forming peer firm portfolios that can account for firm uniqueness and organizational form. Our new vocabulary-based peer firm portfolios explain much cross sectional dispersion in firm valuations and generate a direct measure of firm product market uniqueness. We find that firms have higher stock market valuations than their peers when their products are more unique. This result holds for conglomerate and focused single-segment organizational forms. Increased success in patenting, increased branding, and less venture capital financed entry into the firm's product space all contribute to the long-term maintenance of uniqueness and thus higher valuations. | 30599451 |
4,507,121 | An Investigation of the Accuracy and Reproducibility of 3D Printed Transparent Endodontic Blocks. Due to a broad spectrum of endodontic rotary instruments on the market and no standardised protocol for comparing their mechanical properties, it can be challenging for clinician to choose proper instruments. In vitro studies using resin blocks with artificial canals can offer many valuable information because of their uniformity compared to studies performed on extracted teeth. To improve precision and reproducibility of artificial canals, 3D printing was used in this study to manufacture endodontic test block samples. 20 commercially available endodontic blocks Endo-Training-Bloc-J by Dentsply Sirona were tested. The mean values of the measured parameters were used for a 3D CAD model of their replicas. 20 copies of the endodontic training blocks were printed from acrylic resin (VeroClear-RGD810, Stratasys, Eden Prairie, USA) using the 3D printer Objet30 Pro (Stratasys, Eden Prairie, USA). The key dimensions of the commercial blocks and the 3D printed blocks were measured under and compared using t - test and Levene's test for equality of variances. The profiles of the 3D printed artificial canals showed significantly lower dimensional variability when compared with the commercial blocks. 3D polyjet printing proved to be a precise and reproducible method for production of blocks for testing endodontic rotary instruments. | 254150051 |
4,507,122 | 201Tl myocardial SPECT and beta-endorphin levels in patients with suspected silent ischemia. Today silent myocardial ischemia (SMI) is a well-recognized phenomenon. However, in the absence of clinical signs suggesting coronary artery disease (CAD), a streamlined diagnostic approach for precise clarification has proved to be difficult. Sensitivity and specificity of ergometric results are rather poor in symptom-free patients. Thus the question arises, whether the necessity of coronary angiography can be established more precisely by 201Tl myocardial SPECT in these patients. Treadmill exercise according to the Bruce protocol, 201Tl myocardial SPECT and coronary angiography were performed in a total of 106 patients with suspected SMI. In group I (high probability of ischemia; n = 46), reversible defects detected by SPECT correlated well with significant stenoses and irreversible defects with subtotal stenoses or complete occlusions. SPECT sensitivity in the detection of ischemia was 91%, its specificity 96%. In group II (low probability of ischemia; n = 60), SPECT sensitivity was as high as in group I (94%) but due to a high number of false-positive results (e.g. cardiomyopathy) specificity was only 75%. However, SPECT was superior to exercise ECG (sensitivity 70%; specificity 56%) in the detection of SMI. In addition, beta-endorphin levels were determined in 180 healthy subjects, 37 patients with symptomatic CAD and in 34 patients with SMI before and during maximum exercise. Exercise values in patients with SMI were significantly higher than in healthy subjects or in patients with symptomatic CAD. | 25989201 |
4,507,123 | Hiring Secretaries over Time: The Benefit of Concurrent Employment We consider a stochastic online problem where $n$ applicants arrive over time, one per time step. Upon arrival of each applicant their cost per time step is revealed, and we have to fix the duration of employment, starting immediately. This decision is irrevocable, i.e., we can neither extend a contract nor dismiss a candidate once hired. In every time step, at least one candidate needs to be under contract, and our goal is to minimize the total hiring cost, which is the sum of the applicants' costs multiplied with their respective employment durations. We provide a competitive online algorithm for the case that the applicants' costs are drawn independently from a known distribution. Specifically, the algorithm achieves a competitive ratio of 2.965 for the case of uniform distributions. For this case, we give an analytical lower bound of 2 and a computational lower bound of 2.148. We then adapt our algorithm to stay competitive even in settings with one or more of the following restrictions: (i) at most two applicants can be hired concurrently; (ii) the distribution of the applicants' costs is unknown; (iii) the total number $n$ of time steps is unknown. On the other hand, we show that concurrent employment is a necessary feature of competitive algorithms by proving that no algorithm has a competitive ratio better than $\Omega(\sqrt{n} / \log n)$ if concurrent employment is forbidden. | 465001 |
4,507,124 | Recent Updates to the Advisory Committee On Immunization Practices Recommendations for Pneumococcal and Herpes Zoster Vaccination. Pneumococcal and herpes zoster - shingles - vaccination prevent a great deal of morbidity, particularly in elderly and immunocompromised hosts. Vaccination of children with conjugate pneumococcal vaccine in recent years has greatly reduced illness in older individuals as well. This article will review the historical and current recommendations for pneumococcal and herpes zoster vaccination and the rationale for changes at the level of the CDC's Advisory Committee on Immunization Practices. | 220976901 |
4,507,125 | Intravitreal Combination of Triamcinolone Acetonide and Bevacizumab (Kenacort-Avastin) in Diffuse Diabetic Macular Edema Purpose: To evaluate the effect of intravitreal injection of the combination of Triamcinolone Acetonide and Bevacizumab in patients with diabetic macular edema. Materials and Methods: Twenty seven eyes of 17 patients with diabetic macular edema were treated with an intravitreal injection of triamcinolone acetonide (2 mg) combined with bevacizumab (1.25 mg). Results: During the 6 months follow-up period 24 eyes (89%) had to repeat the treatment according to the monthly follow-up examination.The mean visual acuity and the central macular thickness improved significantly (P<0.05) throughout the follow-up period. Conclusion: Intravitreal combination of Triamcinolone Acetonide and Bevacizumab seems to be effective in improving visual acuity and macular edema in patients with diabetic maculopathy. | 11671401 |
4,507,126 | Complete chloroform dechlorination by organochlorine respiration and fermentation. Chloroform (CF, CHCl(3)) is a recalcitrant and toxic environmental pollutant. In this communication we report for the first time a microbial community capable of complete CF dechlorination by metabolic processes. Cultures derived from subsurface soil (3.5 m) could sustain complete dechlorination of CF at levels of least 360 µM at a rate of 40 µM per day. Scrutiny of CF dechlorination revealed two metabolic processes at work. First, CF was respired to dichloromethane (DCM, CH(2) Cl(2)), which was then fermented to acetate, hydrogen and carbon dioxide. Elevated hydrogen partial pressures were found to inhibit the fermentation process. Interspecies hydrogen transfer was observed in the form of methanogenesis and acetogenesis. This suggests that the dechlorination process required syntrophic partners to maintain low hydrogen partial pressures. (13)C-labelled DCM was employed to help elucidate the chemistry of the process and identify bacterial community members involved. CF respiring cultures, where emulsified vegetable oil was supplied as the electron donor and DCM fermenting cultures, where DCM was supplied as the sole organic carbon source were studied separately. Pyrosequencing of these cultures revealed Dehalobacter lineages as a predominant community member in both. Subsequent growth experiments confirmed that the proliferation of Dehalobacter was linked directly to both the dehalorespiration and dehalofermentation processes. | 30673551 |
4,507,127 | Model predictive assisting control of vehicle following task based on driver model A personalized driver assisting system that makes use of the driver's behavior model is developed. As a model of driving behavior, the Probability-weighted ARX (PrARX) model, a type of hybrid dynamical system models, is introduced. A PrARX model that describes the driver's vehicle-following skill on expressways is identified using a simple gradient descent algorithm from actual driving data collected on a driving simulator. The obtained PrARX model describes the driver's logical decision making as well as continuous maneuver in a uniform manner. Finally, the optimization of the braking assist is formulated as a mixed-integer linear programming (MILP) problem using the identified driver model, and computed online in the model predictive control framework. | 14080451 |
4,507,128 | The roles of recombination and selection in shaping genomic divergence in an incipient ecological species complex. Speciation genomic studies have revealed that genomes of diverging lineages are shaped jointly by the actions of gene flow and selection. These evolutionary forces acting in concert with processes such as recombination and genome features such as gene density shape a mosaic landscape of divergence. We investigated the roles of recombination and gene density in shaping the patterns of differentiation and divergence between the cyclically parthenogenetic ecological sister-taxa, Daphnia pulicaria and Daphnia pulex. First, we assembled a phased chromosome-scale genome assembly using trio-binning for D. pulicaria and constructed a genetic map using an F2-intercross panel to understand sex-specific recombination rate heterogeneity. Finally, we used a ddRADseq dataset with broad geographic sampling of D. pulicaria, D. pulex, and their hybrids to understand the patterns of genome-scale divergence and demographic parameters. Our study provides the first sex-specific estimates of recombination rates for a cyclical parthenogen, and unlike other eukaryotic species, we observed male-biased heterochiasmy in D. pulicaria, which may be related to this somewhat unique breeding mode. Additionally, regions of high gene density and recombination are generally more divergent than regions of suppressed recombination. Outlier analysis indicated that divergent genomic regions are likely driven by selection on D. pulicaria, the derived lineage colonizing a novel lake habitat. Together, our study supports a scenario of selection acting on genes related to local adaptation shaping genome-wide patterns of differentiation despite high local recombination rates in this species complex. Finally, we discuss the limitations of | 246530151 |
4,507,129 | our data in light of demographic uncertainty. | 246530151 |
4,507,130 | Research of Intelligent Dynamic Dispathcing System of High Speed and High Precision AGV : In order to improve the working efficiency of high speed and high precision AGV, the method of path planning in dispatching system is studied, and an improved Astar algorithm is proposed, which can reduce the number of inflection points needed in path planning. The weight ratio of AGV going straight and turning is raised. The improved algorithm is applied to AGV path planning, which improves the efficiency of the algorithm. Experimental results show that the efficiency of this algorithm is higher than that of traditional Astar algorithm in the application of specific enterprise projects. | 216680251 |
4,507,131 | Prevalence of Staphylococcal Enterotoxins in Ready-to-Eat Foods Sold in Istanbul. The aim of this study was to investigate the prevalence of staphylococcal enterotoxins (SEs) in ready-to-eat (RTE) foods sold in Istanbul, Turkey. A total of 5,241 samples were randomly collected from various caterers, hotels, and restaurants from 2014 to 2016. The samples were classified into four groups: (i) various cooked RTE meat and vegetable meals, (ii) various RTE salads, charcuterie, and cold appetizers, (iii) various cooked RTE bakery products (pasta, pastries, pizza, pita, ravioli, etc.), and (iv) any cooked RTE sweets and desserts (pudding, custard, cream, ashura, etc.). The samples were examined for the presence of SEs by 3M Tecra Staph Enterotoxin Visual Immunoassay method, which is a manual enzyme-linked immunosorbent assay method. Among all samples, only 1 (0.019%) RTE meal (vegetable meal with meat) was found to be contaminated with SEs, a good result in terms of staphylococcal food poisoning risk and public health. | 46767951 |
4,507,132 | Function and manipulation tool knowledge in apraxia: Knowing ‘what for’ but not ‘how’ Abstract Several accounts of the semantic system posit that function information plays a critical role in the representations of man-made objects. Alternative possibilities are that man-made objects such as tools are organized according to manner of manipulation, or that both function and manipulation information figure importantly and distinctly in man-made object representations. An agnosic patient, FB, reported by Sirigu et al. (Brain 1991; 114: 727-41) provides support for the latter view. FB was able to demonstrate how to manipulate objects whose function he did not recognize. We now report two severely apraxic patients whose performance, together with that of FBI indicates that function and manipulation information may doubly dissociate. On ‘declarative’ semantic tests not requiring gesture production, our subjects demonstrate severely impaired manipulation knowledge in the context of relatively intact (and, in one subject, perfectly unimpaired) function knowledge. The double dissociation provides further support for the notion that function and manipulation knowledge are critical and distinct features of the representations of manipulable man-made objects. | 143613751 |
4,507,133 | Efficient Bromination of Naphthalene Dianhydride and Microwave-Assisted Synthesis of Core-Brominated Naphthalene Diimides Abstract This article presents an efficient method for the synthesis of core-brominated naphthalene diimides (NDI) from naphthalene dianhydride (NDA). A procedure for monitoring the NDA bromination reaction by 1H NMR spectroscopy is described, allowing for optimization and greater consistency of this reaction. Furthermore, the subsequent bis-imidization reaction of the brominated NDA product has been significantly enhanced using microwave-assisted conditions, with recovery of pure product via simple filtration in excess of 90% of theoretical yield. This chemistry offers greatly improved methodology for obtaining core-substituted NDI compounds with high efficiency and good yields. GRAPHICAL ABSTRACT | 94851501 |
4,507,134 | Study on Control System of SCM Palletizing Robot Arm This paper studies the joint type palletizing robot arm, using MFC application platform designed a four-axis palletizing robot arm control software. Software in the paper we design has friendly interface, the operator through the input palletizing basic information, and then introduced with the steering gear control and DSP implementation of serial communication programming, and system hardware circuit was designed by palletizing robot arm control system simulation tests were conducted to verify system functions. | 108582251 |
4,507,135 | Results of Corrective Surgery for Alkaline Reflux Gastritis Reflux alkaline gastritis and esophagitis have been incriminated as a source of symptoms in achlorhydric patients after operation for duodenal ulcer. Documentation of such pathologic findings has increased due to widespread use of fiberoptic endoscopy. As reported in the literature, results of remedial operations have ranged from encouraging to excellent, and evaluations have been uniformly laudatory. Correlation of the extent of symptoms and of pathologic findings has been difficult, and our results have not been as good as those reported in the literature. During a six-year period, the diagnosis of bile reflux gastritis in 13 patients was based on a characteristic symptom complex, endoscopic appearance, and histopathologic confirmation. Either a Roux-en-Y gastrojejunostomy or a Tanner-Roux 19 was the corrective procedure. There was complete relief of symptoms in five patients (38%) and partial relief in four, but no apparent relief in four others. In at least three of the patients, chronic gastritis and/or esophagitis have persisted and have not improved despite biliary diversion. Tabulation of the results of 13 remedial operations for reflux alkaline gastritis disclosed that complete relief of symptoms was achieved in 50% of those who had the Roux-en-Y and in 20% of those who had the Tanner 19 procedure. Based on our findings, we recommend a cautious approach to the surgical management of alkaline gastritis. | 32473051 |
4,507,136 | THE ROLE OF PARENTAL INVOLVEMENT IMPACT ON CAREER DECISIONS MAKING AMONG SENIOR SECONDARY SCHOOL STUDENT IN SELECTED PROVINCE OF BHUTAN The present research was carried out to forecast the protagonist of parental involvement in the Career Decision making among students of Senior Secondary School. This study was basically descriptive method used to acquire important and accurate information. The main objectives were to analyze the inter-relationship between career decision making and perceived parental involvement of senior secondary school of Bhutan. And another objective was to study the role of perceived parental involvement on the relationship between career decisions making among students of senior secondary school. The investigator selected 300 senior secondary school students through convenient sampling technique. For the collection of data the investigator used Career Decision making scale, developed by Dr. Kirandeep Singh in 2014 and Parental Involvement tool developed by Dr. Vijayalaxmin Chouhan and Mrs. Gunjan Ganotra Arora in 2009. For the purpose of drawing out the results the investigator used statistical techniques like Coefficient of Correlation and Regression Analysis were used. The outcome showed that a significant negative relationship exists between Career Decision Making and Parental Involvement of senior secondary school students of Bhutan. Also, parental involvement plays a significant predictor role in the career decision making of school students. | 199250601 |
4,507,137 | Exploration of the Cause of the Low Intensity Aortic Component of the Second Sound in Nonhypotensive Patients with Poor Ventricular Performance SUMMARYThis investigation was undertaken to explore the cause of the diminished second sound (S2) that may occur in normotensive patients with poorly performing ventricles. Intraaortic sound and pressure were measured in 16 patients with angina; eight had normal ventricular performance (ejection fraction .60%) and eight had poor performance (ejection fraction < 50%). The amplitude of S, was lower in patients with poor ventricular performance as was negative dp/dt. Aortic pressure was com- parable in both groups. The ampitude of S2 was linearly related to the rate of change of the pressure gradient that developed across the aortic valve during diastole (r = 0.82). The latter also correlated with negative dp/dt (r = 0.82). These observations indicate that in patients with poor ventricular performance, isovolumic relaxation may be compromised. This would cause a reduction of the rate of development of the diastolic pressure gradient, which would result in a diminished S2. | 595301 |
4,507,138 | A General Description of an Information Disseminating Scheme and Its Automorphism We describe an information disseminating scheme on a processor network in a general form. An automorphism with respect to the information disseminating process on the network is introduced. Conditions for the existence of such an automorphism and the effect of the start round to the fault tolerance of the scheme are studied. あらまし プロセッサネットワーク上の情報散布方式を一般的に記述する。 ネットワーク上の情報散布過程 に対応した自己同型写豫を紹介する。 自己同型写像が存在する条件とスキームの耐故障性へのス タートラウンドの影響について議論する。 | 118295051 |
4,507,139 | The recruitment of volunteers into a community programme for older people: lessons learned The recruitment of sufficient volunteers is a key challenge that many non-profit organisations face. There remains a lack of research exploring the implementation of best practice processes to recruit appropriate volunteers into relevant programmes. This paper details the processes underpinning a volunteer recruitment strategy for a community-based programme, reflects on the outcomes of recruitment, and discusses key learnings and implications for practice to guide other researchers and non-profit stakeholders to effectively recruit young adult volunteers. | 235840701 |
4,507,140 | [Endovascular treatment for abdominal aortic aneurysm, a primary study]. OBJECTIVE To summarize the initial experience of endoluminal stent-grafting in the treatment of abdominal aortic aneurysm (AAA). METHODS Stent-graft of proper shape and size was selected according to the morphology of AAA and was inserted into the lumen of abdominal aortic aneurysm through femoral artery to reconstruct the blood flow under X-ray flouroscopy among 34 cases. Data on complications and morphological changes were obtained according to a strict follow-up plan. RESULTS The stent-grafting procedure was technically successful in all 34 patients. None of them required open repair. Five patients (14.7%) suffered from primary endoleaks after stent-graft deployment and 1 patient suffered from paraplegia and acute graft thrombosis. No other complications (kidney infarction, limbs and colon ischemia, etc) were found. The average follow-up time was 21 +/- 4.7 months. Perioperative death rate was 0% and total death rate was 3%. Two cases with primary endoleak developed into lasting endoleak during the follow-up period with a rate of late endoleak (> 30 days) of 11.7%. Secondary endoleak was found in 2 cases. One case with limb stent disconnection accepted secondary intervention. The mean max aneurysm diameter in cases without endoleak decreased significantly 6 months to 2 years after operation (P < 0.01). The aneurysm in two cases with secondary type I endoleak increased and one of them underwent secondary intraluminal treatment. CONCLUSION Endovascular technique is a reliable method of treating AAA with micro-trauma. Endoleak is the main complication of this technique. Follow-up is an important component of the treatment | 31866101 |
4,507,141 | plan. The aim of endoluminal repair is to completely neglect the aneurysmal lumen and prevent the aneurysm from increasing during follow-up. | 31866101 |
4,507,142 | Primary non-Hodgkin's lymphoma of the brain revisited. Primary cerebral non-Hodgkin's lymphoma of the brain are very rare neoplasms. The pertinent data describing these tumours have been gathered in retrospect and from reviews of postmortem materials. There has been increased interest in this disorder in recent years because of improved diagnostic capabilities. The computerized axial tomography and radiopharmaceutical uptake brain scintiscans are invaluable prebiopsy non-invasive investigative procedures. Brain biopsy and minimal tumour resection are nowadays the preferred modes of surgical treatment. Because more radical surgery and whole brain radiation have failed to control the high rate of systemic relapses, it is generally recommended that Chemotherapy should be incorporated into the primary treatment plan. High dose intravenous methotrexate has been shown to be effective in treatment of residual lymphoma and systemic recurrent tumours. | 37269351 |
4,507,143 | Experimental validation of Monte Carlo calculations with a voxelized Rando–Alderson phantom: a study on influence parameters The development and improvement of techniques for an accurate dose assessment in medical physics is an important task. In this study, we focus on the validation of Monte Carlo calculations, by comparing organ doses assessed experimentally with thermoluminescent detectors in the Rando–Alderson phantom with doses calculated for a voxelized model of the same phantom for some typical x-ray procedures. A detailed study has been performed to identify the key parameters that affect the determination of organ doses. Initially, TLD measurements were up to 65% higher than the calculated values. After the corrections made on TLD energy dependence, TLD angular dependence, material composition and field size and position, most differences between measurements and calculations are within 15%. For organs far away from the field the difference is about 30%. | 40768451 |
4,507,144 | Lymphocyte counts and the risk of COVID-19 in people with MS In their report of coronavirus disease 2019 (COVID19) among people with multiple sclerosis (MS), the Dutch MS Taskforce of the Netherlands Society of Neurology did not find an association between lymphocyte counts and the severity of the disease,1 which was similar to the findings of the Covisep registry study.2 Furthermore, people with MS taking diseasemodifying therapies (DMTs) that induce lymphopenia are not necessarily at risk of poorer outcomes from COVID-19.1–3 | 222834101 |
4,507,145 | Silence and Sacrifice: Family Stories of Care and the Limits of Love in Vietnam By Merav Shohet. Berkeley: University of California Press, 2021. 267 pp. ISBN: 9780520379381 (paper). 4 details the purge of the PKI’s stronghold in Surakarta by the Army Paracommando Regiment (RPKAD) under Colonel Sarwo Edhie in early October, which escalated the anti-communist propaganda campaign from rhetorical to murderous. “Both the incitement to kill and the precedent of the killings in Central Java created and atmosphere of war in the entire country” (p. 143). Chapters 5 and 6 examine the delay in the killings in Bali caused by the resistance of governor Sutedja and head of the region’s Territorial Command, Brigadier General Sjafiudin. By mid-December, traditional elites in the Indonesian National Party (Partai Nasional Indonesia), seeing an opportunity to liquidate their economic rivals in the PKI, successfully lobbied the Central Command in Jakarta to send RPKAD troops to override Sutedja and Sjafiudin’s resistance and commence the killings. Chapter 7 continues to build on Roosa’s analysis of “resisters” as a crucial addition to the “perpetrator, victim, and bystander” triadic paradigm of genocide studies (p. 151). A comparison of seemingly similar regions in South Sumatra and Riau showcases how successful resistance in Riau resulted in far fewer deaths than in South Sumatra. The chapter also expands upon the economic motivations examined in Bali to define the killings as not merely a political genocide, but a wholesale liquidation of organized labor. Buried Histories is a must-read for historians of modern Indonesia, scholars of genocide studies, and specialists | 248673601 |
4,507,146 | in the field of interrogational torture. But beyond that scholarly endeavor, within the pages of Buried Histories lie numerous heart-wrenching accounts of human suffering which could be appreciated by many outside of the academy. It is an emotionally devastating book which will likely play a pivotal role in Indonesia’s long road to reconciliation. | 248673601 |
4,507,147 | Contesting governance of indigenous forests in New Zealand: The case of the West Coast Forest Accord Abstract This paper uses the concept of ‘governance’ and the related notion of ‘multi-layered’ forest management decision making as an overarching framework for analysis of conflict between different stakeholder groups with contrasting perceptions about ‘appropriate’ use of indigenous forests in a New Zealand case study. In New Zealand, recent institutional reforms inspired by neo-liberal policy agendas have led to substantial conflicts between segments of society over the ‘appropriate’ governance of remnant indigenous forests. This study focuses on the West Coast Forest Accord (WCFA) as an illustration of the attempt to change governance structures of indigenous forest management by re-regulating the indigenous forest industry. It is argued that by seeking to accommodate multiple stakeholder interests, in particular industry, community and environmental groups, the WCFA was doomed to fail, as multiple, and often conflicting, stakeholder agendas focused on the goal of ‘sustainable management’ of indigenous forests could no longer be reconciled. Notwithstanding the shift in emphasis from government towards governance in the recent literature, the study findings confirm a continuing strong role by the state as an actor in the forestry sector in New Zealand. | 154467051 |
4,507,148 | Dynamic Experimental Investigation on the Fundamental Frequency of Liquid Storage Tanks under Seismic Excitations A large-scale earthquake simulation experiment about the unanchored cylindrical steel liquid storage model tanks has been completed. The fundamental frequency of the model tank with liquid inside was investigated based on the experimental data of the acceleration dynamic response. The seismic table test, the analysis methods are designed and conducted, and experimental results of the model tank were carefully measured. Furthermore, national design standard was used to calculate the fundamental frequency of the model tank system. The reasons for the existence of consistency and differences between the results obtained from experiments and national design standard were discussed. | 109414351 |
4,507,149 | Balancing Incident and Ambient Light for Illumination Compensation in Video Applications Hand-gesture interaction with a smart TV using a conventional camera under restricted ambient illumination is complicated by the varying incident illumination coming from the screen. In this paper, we propose a method for compensating for the poor ambient illumination in the scene captured by a smart TV camera by balancing it against this kind of incident illumination. The proposed framework models the variations in the ambient illumination as a factor of the varying incident illumination caused by the changing multimedia content displayed on the smart TV. Further, by estimating the average incident illumination and measuring its deviation during the scene transition, an illumination intensity correction factor is deduced, and thus ambient illumination is corrected iteratively. To validate the effectiveness of the proposed method, we benchmark it against multiple video sequences depicting the human gesture interaction with a smart device under both low-lighting (typically in the night) and natural-lighting conditions. Furthermore, experiments on such challenging video sequences have demonstrated improved accuracy and robustness of visual target trackers by preprocessing the sequence using our method. | 52191451 |
4,507,150 | Alleviating mortality associated with a vitamin E-selenium deficiency by dietary ascorbic acid. Adding ascorbic acid to a practical ration deficient in vitamin E and selenium for the growing duck substantially reduced associated mortality. The continued appearance of various myopathies but absence of vascular faults supported implication of a reduced de novo ascorbate synthesis as part of the syndrome. Presumably, alleviation of this induced secondary inadequacy with its more lethal pathology was the primary reason for the lower death rate. | 3637601 |
4,507,151 | Photo-Curing Schemes to Cure the Epoxy Resins and their Impacts on Curing Process Different schemes to photo-cure the epoxy resins are reviewed in this article. Photo curing of epoxy resin by UV-polymerization mechanism is one of the effective methods. “A light induced chemical practice to cure the dry composites i.e. coatings or films are the termed as photo curing”. The most important fact of photo curing is that it gives best performance, eco-friendly compatibility, and efficacy of processing. So, due to these facts, thermal curing is replaced by photo curing. Photo curing is applicable only for the films of definite thickness and colored composites. Epoxy resin and photo initiator were mixed together and then mixtures were cured through a curing reaction which was proceeded in the presence of infrared or ultraviolet light (UV-Light), or an electron beam. | 209430151 |
4,507,152 | Quantum-well memory device (QWMD) with extremely good charge retention We propose and demonstrate a new device that utilizes a quantum well (its dimensions determined by two self-limiting processes) as a floating gate. We show that fast programming and erasing can be achieved. Excellent charge retention (ten years) is obtained, for 2.7 nm thin tunneling oxide, at room temperature, and for 5 nm thin tunneling oxide even at elevated temperature. | 44051351 |
4,507,153 | THE ROLE OF GLUTAMINE SYNTHETASE IN THE INCORPORATION OF AMMONIUM IN SKELETONEMA COSTATUM (BACILLARIOPHYCEAE) 1 The Km for ammonia for glutamine synthetase and glutamate dehydrogenase was measured in enzyme extracts from Skeletonema costatum (Grev.) Cleve. At similar physiological pH and temperature the half‐saturation constant for glutamine synthetase was 29 μM, whereas for GDH it was 28mM. On the basis of relative enzymic activity, as well as substrate affinity, it is suggested that glutamine synthetase is the enzyme primarily responsible for the incorporation of ammonium into the amino acid pool, when extracellular nitrogen is at ecological concentrations. | 84226501 |
4,507,154 | Corrosion Behavior of Anodized 7B50 Aluminum Alloy in Different Atmospheric Environments The corrosion behavior and mechanism of 7B50 aluminum alloy anodized in sulfuric acid solution were studied through outdoor exposure tests in industry-marine and northern semirural atmospheric environments in Qingdao and Beijing, respectively, by means of morphological observation, weight-loss measurement, X-ray diffraction and electrochemical impendence spectroscopy (EIS). The results showed that the average corrosion rates of the anodized alloy decreased by 91.9% and 56.2% after one-year exposure in the industry-marine and northern semirural atmospheric environments, respectively, compared to the naked alloy. Thus the anodic treatment weakened corrosion and the effect was much better in the harsh environment. The high concentration of chloride ions in Qingdao played an important role in the destruction of the oxide films and in inducing the pitting corrosion. Due to the pitting on the grain boundaries and the microgalvanic corrosion among the grain boundary precipitates, precipitate-free zone and the matrix, the intergranular corrosion initiated and propagated throughout the sample. The sulfide in both atmospheres had a remarkable impact on the corrosion of 7B50 Al alloy, which aggravating surface and intergranular corrosion. The aggravation in Qingdao was much more serious. After exposure in Qingdao and Beijing, the anodized film remained an effective hindrance for aggressive ions penetrating to the matrix, and the barrier ability of the alloy in Beijing was better due to the intact double-layer structure of the film as well as the atmosphere’s low humidity and low chloride ion concentration. The rust layer formed on the naked alloy was loose and | 198359001 |
4,507,155 | cracked, which could not effectively obstruct the matrix corrosion. | 198359001 |
4,507,156 | DC image restoration for astronomical applications In astronomical imaging techniques, the relative level of the zero-frequency component of an image is usually unknown relative to all other components. This problem arises because the overall object brightness cannot easily be separated from background when viewing small, faint objects. This affects image interpretability and therefore is a problem that is ubiquitous in high-resolution astronomical imaging. Potential solutions to this problem include various interpolation techniques and image-constraint techniques. These approaches are described, and performance is evaluated with an optimal interpolator that accounts for sample density, signal-to-noise ratio, and the object's overall shape. Novel analytic expressions are obtained which provide insight into the limitations of any restoration approach, and practical means for achieving those limits. | 122953351 |
4,507,157 | Granulocytic sarcoma of the breast: a case report Granulocytic sarcoma (GS) known as myeloid sarcoma, chloroma, myeloblastoma, or extramedullary myeloid tumor is a neoplasm composed of immature myeloid cells. The common sites of this tumor involvement include bone, central nervous system, soft tissue, lymph nodes, and skin. The involvement of GS in breast tissue is very rare. The incidence of breast GS is 2/1,000,000 in adults. The affected people range in age from 16 to 72. The mean age is 31. Primary, isolate, or non-leukemic GS of breast is defined when bone marrow biopsy confirms the absence of other hematologic malignancy. We here report a case of granulocytic sarcoma of the left breast in a 33 year-old woman who presented with a breast mass. This case was initially diagnosed as diffuse lymphoma, large cell type on H&E histopathology. The tumor cells were, however, strongly positive for myeloperoxidase (MPO), CD117, CD34, and CD43 but negative for CD45, CD20, CD3, or cytokeratin. Although the clinical information such as complete blood count or aspiration biopsy of bone marrow tissue was absent, we finally diagnosed this case as GS by additional immunohistochemical study. Introduction Granulocytic sarcoma (GS) known as myeloid sarcoma, chloroma, myeloblastoma, or extramedullary myeloid tumor is a neoplasm composed of immature myeloid cells. [1][2][3][4] The common sites of this tumor involvement include bone, central nervous system, soft tissue, lymph nodes, and skin. [5][6][7] The involvement of GS in breast tissue is very rare. [1][3] The incidence of breast GS is 2/1,000,000 in adults. [8] The affected people range | 22354101 |
4,507,158 | in age from 16 to 72.The mean age is 31. The GS in breast presents with an infiltrative pattern which is similar to lymphoma or invasive lobular carcinoma. [1][9] Primary, isolate, or nonleukemic GS of breast is defined when bone marrow biopsy confirms the absence of other hematologic malignancy. [8] We here report a case of granulocytic sarcoma of the left breast in 33 years old woman who presented with a breast mass. This case was initially diagnosed as diffuse lymphoma, large cell type on H&E histopathology. Although the clinical information such as complete blood count or aspiration biopsy of bone marrow tissue was absent, we finally diagnosed this case as GS by additional immunohistochemical study. Case report The patient was 33 years old female presenting with a palpable mass in the left breast. No enlargement of axillary lymph nodes was found by the physical examination. She had neither nipple discharge nor skin lesion, and had no history of familial breast cancer. The breast mass was removed by mastectomy. We received the breast mass as a mastectomy specimen. It | 22354101 |
4,507,159 | Fatal necrotizing stomatitis due to Trichoderma longibrachiatum in a neutropenic patient with malignant lymphoma: a case report. Primary invasive mold infection of the oral cavity is a rare but serious complication in immunocompromised hosts. We report a case of fatal Trichoderma longibrachiatum stomatitis in a 66-year-old female patient with malignant lymphoma. The infection rapidly disseminated from the oral mucosa to the lungs during neutropenia. Despite intensive antifungal therapy with amphotericin B and itraconazole, there was a fatal progression of the condition. While Trichoderma species have been recognized to be pathogenic in profoundly immunosuppressed hosts, this is the first report of the primary oral focus causing a fatal infection. | 35795251 |
4,507,160 | SOX, Corporate Transparency, and the Cost of Debt We investigate the impact of the Sarbanes–Oxley (SOX) Act on the cost of debt through its effect on the reliability of financial reporting. Using Credit Default Swap (CDS) spreads and a structural CDS pricing model, we calibrate a firm-level corporate opacity parameter in the pre- and post-SOX periods. Our analysis shows that corporate opacity and the cost of debt decrease significantly after SOX. The median firm in our sample experiences an 18bp reduction on its five-year CDS spread as a result of lower opacity following SOX, amounting to total annual savings of $ 844million for the 252 firms in our sample. Furthermore, the reduction in opacity tends to be larger for firms that in the pre-SOX period have lower accrual quality, less conservative earnings, lower number of independent directors, lower S& P Transparency and Disclosure ratings, and are more likely to benefit from SOX-compliance according to Chhaochharia and Grinstein’s (2007) criteria. | 56248101 |
4,507,161 | How can OpenShift accelerate your Kubernetes adoption: a workshop exploring OpenShift features OpenShift is a Kubernetes distribution which comes with additional capabilities for developers and operators to make building and running cloud-native applications easier. This hands-on workshop walked the participants through the deployment of an application in an OpenShift cluster. Origin Community Distribution of OpenShift (referred to as OKD) is the Kubernetes distribution that powers OpenShift. With Minishift version 3.x, participants can use OKD to get some hands-on experience of OpenShift locally. In addition to managed Kubernetes clusters, IBM Cloud also offers managed OpenShift clusters which leverages a lot of the same infrastructure as the Kubernetes clusters. We also demonstrated how to deploy the application into a paid IBM Cloud OpenShift cluster. We highlighted the similarities and differences between tasks performed in Kubernetes and OpenShift to illustrate the value of using OpenShift. We compared Kubernetes and OpenShift through real example configuration, setup and deployment. | 213237751 |
4,507,162 | 1261-P: Is Glycemic Control Better in Adults with Type 1 Diabetes When Office Visits are Supplemented with Telehealth Visits? Objective: Since the COVID-pandemic began, instead of in-office care alone, many institutions implemented hybrid care (in-office + telemedicine) . It is not known if hybrid care is as effective as in-office visits in regards to achieving glycemic goals. Methods: Clinical characteristics of adults with type 1 diabetes (T1D) (age ≥40 years) were retrieved from electronic health records from two periods: in-office model before the pandemic (April 2019-March 2020) and hybrid-care model during the pandemic (September 20pril 2021) . Patients were stratified by age. Results: Overall, 1,820 patients were evaluated, 66% younger (40-64 years: mean age 52±7yrs, 52% female, 53% CGM users, 56% pump users) and 34% older (≥65 years: mean age 72±5yrs, 55% female, 53% CGM users, 38% pump users) . A1c using hybrid-care improved in both younger (7.8±1.2 vs. 7.6±1.2%; p=0.005) and older adults (7.6±0.9 vs. 7.4±1%; p=0.02) , compared to in-office care. Within the hybrid-care model period, poor glycemic control was associated with a higher number of hybrid visits, and more in-office missed appointments, while pump use was associated with lower A1c. Conclusion: Compared with in-office care, hybrid care was effective at maintaining glycemic control in both younger and older adults with T1D. Prospective studies are needed to understand the use of hybrid-care for the management of adults with T1D. E.Toschi: Consultant; Medtronic. A.Adam: None. C.Slyne: None. L.M.Laffel: Advisory Panel; Medtronic, Roche Diabetes Care, Consultant; Boehringer Ingelheim International GmbH, Dexcom, Inc., Dompé, Insulet Corporation, Janssen | 249249001 |
4,507,163 | Pharmaceuticals, Inc., Lilly Diabetes, Novo Nordisk, Provention Bio, Inc. M.Munshi: Consultant; Sanofi. | 249249001 |
4,507,164 | Theoretical study on the spin-state energy splittings and local spin in cationic [Re]-Cn-[Re] complexes. Total spin-state energy splittings are calculated for mono- and dications of the formula {[Re]-Cn-[Re]}z+ where [Re] = eta5-(C5Me5)Re(NO)(PPh3). Cn is an even-numbered carbon chain with n ranging from 4 to 20, and z is 1 or 2. These complexes are experimentally known, and their potential role as molecular electronic devices initiated this work. We have considered the different total spin states monocation/doublet, monocation/quartet, dication/singlet, and dication/triplet. Data obtained for two density functionals BP86 and B3LYP were compared to verify the internal consistency of the results. In both ionization states, the low-spin state is the ground state, but the spin-state splittings decrease as the chain gets longer. For the dications, the splitting reaches a nearly constant value of about 10 kJ/mol with BP86 and about 4 kJ/mol with B3LYP when there are at least 14 carbon atoms in the chain, whereas for the monocations, no constant value appears to be reached asymptotically, not even if 20 carbon atoms are in the chain. For monocations, the splittings range from 138 kJ/mol (n = 4) to 68 kJ/mol (n = 20) with BP86 and from 134 kJ/mol (n = 4) to 73 kJ/mol (n = 20) with B3LYP and are thus considerably higher than those of the dications. The spin-state splittings are qualitatively mirrored by the energy splitting between the highest-occupied molecular orbital with beta spin (HOMObeta) and the lowest-unoccupied molecular orbital with alpha spin (LUMOalpha) as obtained in the low-spin state. Furthermore, the HOMOalpha-LUMOalpha | 21529301 |
4,507,165 | gaps decrease as the carbon chain lengthens. In addition, the local distribution of the ŝz expectation value is analyzed for the monocation/doublet, the monocation/quartet, and the dication/triplet state using a modified Löwdin partitioning scheme. In the monocation/doublet and the dication/triplet state, the electron spin is distributed mainly on the metal centers and slightly delocalized onto the carbon chain. In the monocation/quartet state for chain lengths of more than 8 carbon atoms, the electron spin is mainly localized on selected atoms of the chain and not on the metal centers. In all cases, the spin delocalization onto the chain increases as the chain gets longer. | 21529301 |
4,507,166 | Transforming Governance: How National Policies and Organizations for Managing Disaster Recovery Evolved following the 4 September 2010 and 22 February 2011 Canterbury Earthquakes Large-scale disasters simultaneously deplete capital stock and services which then requires many complex rebuilding and societal activities to happen in a compressed time period; one of those is governance. Governments often create new institutions or adapt existing institutions to cope with the added demands. Over two years following the 4 September 2010 and 22 February 2011 Canterbury earthquakes, governance transformations have increasingly centralized recovery authority and operations at the national level. This may have helped to strengthen coordination among national agencies and expedite policy and decision making; but the effectiveness of coordination among multiple levels of government, capacity building at the local and regional levels, and public engagement and deliberation of key decisions are some areas where the transformations may not have been as effective. The Canterbury case offers many lessons for future disaster recovery management in New Zealand, the United States, and the world. | 110290901 |
4,507,167 | Newcastle disease virus suppresses angiogenesis in mammary adenocarcinoma models Cancer cells heavily utilise angiogenesis process to increase vascularisation for tumour mass growth and spread, so targeting this process is important to create an effective therapy. The AMHA1 strain of Newcastle disease virus (NDV) is an RNA virus with natural oncotropism. NDV induces direct tumour cytolysis, apoptosis, and immune stimulation. This work aimed to test NDV anti-angiogenic activity in a breast cancer model. To evaluate NDV’s antitumour effect in vivo, NDV was tested against mammary adenocarcinoma AN3 transplanted in syngeneic immunocompetent mice. In vivo antiangiogenic activity was evaluated by quantifying the blood vessels in treated and control tumour sections. In vitro experiments that exposed AMN3 mammary adenocarcinoma cells and Hep-2 laryngeal carcinoma cells to NDV at different time intervals were performed to identify the exact mechanism of anti-angiogenesis by using angiogenesis microarray slides. In vivo results showed significant tumour regression and significant decrease in blood vessel formation in treated tumour sections. The in vitro microarray analysis of 14 different angiogenesis factors revealed that NDV downregulated angiopoietin-1, angiopoietin-2, and epidermal growth factor in mammary adenocarcinoma cells. However, NDV elicited a different effect on Hep-2 as represented by the downregulation of inducible protein 10, intracellular adhesion molecule-1, and basic fibroblast growth factor beta in NDV-infected tumour cells. It was found out that microarray analysis results helped interpret the in vivo data. The results suggested that the NDV oncolytic strain reduced angiogenesis by interfering with angiogenesis factors that might reduce tumour cell proliferation, infiltration, and invasion. | 247367501 |
4,507,168 | Spatiotemporal stochastic resonance in an array of Schmitt triggers We report on stochastic resonance in an array of four unidirectionally coupled Schmitt triggers driven by global noise and a spatiotemporal modulation. By introducing phase shifts in the drives of these bistable electronic triggers we were able to control the amplification of the periodic input signal, which is a characteristic of stochastic resonance. For phase shifts allowing for periodic boundary conditions, we found array-enhanced stochastic resonance. Moreover, evidence for spatiotemporal stochastic multiresonance was obtained, where the array exhibits more than one maximum of amplification. We attribute these phenomena to a competition between the external drive and the coupling of an array element with its neighbor. | 119405851 |
4,507,169 | Classification of ADHD/normal participants using frequency features of ERP's Independent Components This study investigates the Event Related Potentials (ERP) obtained from Independent Components of EEG (ERPIC) while participants performed a sustained attention task. EEG signals were recorded from 50 adult participants including ADHD and normal subjects while performing Continuous Performance Test (CPT). Signals were recorded from 21 Ag/AgCl electrodes according to the international 10–20 standard. Independent Component Analysis (ICA) was used as the processing method. For ERP extraction, average of each group of signals which were time-locked to the onset of stimuli was calculated. Several frequency features were extracted from different ERPICs. High accuracy (92%) was achieved in classification of clinical and non-clinical participants using combination of two features in a K-Nearest Neighbors (KNN) classifier. Nine pairs of features resulted in such accuracy, while most of the best features are related to the power in γ band which is consistent with the previous studies. Regarding the ERP groups, most of the best features are related to wrong answered targets and to time block ERPICs. The results revealed a promising relation between clinical situation of the participants and some parameters of brain independent components which can be used for further evaluations of the sustained attention level. | 37041401 |
4,507,170 | Effect of Ground Fissures on Subsidence in Xi'an Metro Line 2 The subsidence value in fissure site and no fissure site respectively is calculated when ground water is pumped. The relationship between ground fissures and ground subsidence is determined by calculation and then the cause of land subsidence is concluded. This study can solve the problem of ground subsidence in the construction of south section of Xian metro line 2 and it offers theoretic basis of prevention and treatment. | 110391251 |
4,507,171 | Litter-size-dependent intrauterine growth restriction in sheep. Regulation of foetal development in sheep depends on interactions between the intrinsic capacity of the foetus for growth and the maternal environment. Lambs born in multi-foetus litters have relatively small placentae with fewer cotelydons, and lower birth weights. Litter-size-dependent intrauterine growth restriction (IUGR) is evident at mid gestation when metabolic needs of the conceptus are moderate, and overnutrition of ewes with multiple foetuses does not promote growth of their foetuses to the size of singletons. Those observations suggest that placental and conceptus growth in multi-foetus pregnancies is reprogrammed at mid gestation by an as yet undefined mechanism to attenuate foetal growth. This may protect the foetus from severe nutritional insult during late gestation, when its daily growth rate is at a maximum. In that way, lambs born in large litters with relatively lower birth weights may not experience the long-term physiological insults that can be observed in small lambs born to undernourished ewes. | 2344051 |
4,507,172 | Design and implementation of web server soft load balancing in small and medium-sized enterprise With the expansion of business scale, small and medium-sized enterprises began to use information platform to improve their management and competition ability, the server becomes the core factor which restricts the enterprise's infomationization construction. This paper puts forward a suitable design scheme for small and medium-sized enterprise web server soft load balancing, and proved it effective through experiment. | 62748901 |
4,507,173 | Underuse of aspirin for secondary prevention of vascular disease 0.2 0.5 2 5 Favours control Favours intervention numbers while undertaking the mandatory two years of supervised general practice work. By limiting places in this program the federal government has defined the number of people able to enter general practice in Australia. Accurate workforce data are notoriously difficult to obtain, but it would appear that there are about 1200 to 1300 medical practitioners entering the workforce in Australia each year (local graduates and overseas-trained graduates who successfully complete the AMC examination). It is likely that there will be shortages in many areas, and I see no justification for limiting general practice training places to 400 per year. Jones is rightly concerned about the effect of reducing the availability of general practitioners (GPs) in Australia. Competent GPs who have achieved standards such as those set by the Royal Australian College of General Practitioners' Fellowship examination have been shown to be the most cost-efficient providers of primary healthcare to the community.' Limiting access to these practitioners will mean that healthcare will be provided by other practitioners (eg, specialist physicians or nurse practitioners) at a significantly greater community cost. A short to medium term benefit, as has occurred with the flattening of the Medicare rebate increase curve since provider number and training place restrictions were imposed, will be reversed in the long term by a less cost-efficient primary healthcare system. Within the medical profession we should all be lobbying for the establishment of an appropriate number of general practice training | 44559051 |
4,507,174 | places around Australia. | 44559051 |
4,507,175 | Density control of poly(ethylene glycol) layer to regulate cellular attachment. A wide variety of cells usually integrate and respond to the microscale environment, such as soluble protein factors, extracellular matrix proteins, and contacts with neighboring cells. To gain insight into cellular microenvironment design, we investigated two-dimensional microarray formation of endothelial cells on a micropatterned poly(ethylene glycol) (PEG)-brushed surface, based on the relationship between PEG chain density and cellular attachment. The patterned substrates consisted of two regions: the PEG surface that acts as a cell-resistant layer and the exposed substrate surface that promotes protein or cell adsorption. A PEG-brushed layer was constructed on a gold substrate using PEG with a mercapto group at the end of the chain. The density of the PEG-brushed layer increased substantially with repetitive adsorption/rinse cycles of PEG on the gold substrate, allowing marked reduction of nonspecific protein adsorption. These repeated adsorption/rinse cycles were further regulated by using longer (5 kDa) and shorter (2 kDa) PEG to construct PEG layers with different chain density, and subsequent micropatterning was achieved by plasma etching through a micropatterned metal mask. The effects of PEG chain density on pattern formation of cell attachment were determined on micropatterning of endothelial cells. The results indicated that cell pattern formation was strongly dependent on the PEG chain density and on the extent of protein adsorption. Notably, a PEG chain density high enough to inhibit outgrowth of endothelial cells from the cell-adhering region in the horizontal direction could be obtained only by employing formation of a short filler layer of PEG | 6263561 |
4,507,176 | in the preconstructed longer PEG-brushed layer, which prevented nonspecific protein adsorption almost completely. In this way, a completely micropatterned array of endothelial cells with long-term viability was obtained. This clearly indicated the importance of a short underbrushed PEG layer in minimizing nonspecific protein adsorption for long-term maintenance of the active cell pattern. The strategy for cell patterning presented here can be employed in tissue engineering to study cell-cell and cell-surface interactions. It is also applicable for high-throughput screening and clinical diagnostics, as well as interfacing cellular and microfabricated components of biomedical microsystems. | 6263561 |
4,507,177 | Development of urban land grading information system based on component GIS The urban land grading information system can realize automatic and dynamic management on land grading. The technology of components geographic information system (ComGIS) stands on the current tide with GIS development. SuperMap Objects, which have been developed by SuperMap Corporation in Beijing and are composed of a series of ActiveX components, have strong GIS functional power. Firstly, the method and technology of urban land grading are discussed; secondly, the database design, structure and function, integration model and main techniques about the urban land information system are analyzed in detail; finally, the system realization is expounded for selecting Visual Basic as development environment and SuperMap Objects as ActiveX. The system based on ComGIS can enhance the work of land grading greatly. | 16424411 |
4,507,178 | A Model Driven Method to Design and Analyze Secure Architectures of Systems-of-Systems Context: Systems-of-Systems (SoS) is becoming the major paradigm for engineering next generation solutions such as smart cities, health-care and emergency response. However, SoS differentiating characteristics, such as emergent behavior, may introduce specific issues that make ensuring their security a critical challenge. Objective: the aim of this study is to investigate how Software Engineering approaches can be extended to model and analyze secure SoS solutions for discovering high impact cascading attacks at the architecture stage. Method: in order to achieve our objective, we followed the guidelines of Model Driven Engineering to propose a method, Systems-of-Systems Security (SoSSec), that comprises: (1) an architectural description language for modeling SoS and its vulnerabilities and (2) a MultiAgent System for security analysis of SoS architectures. | 3441461 |
4,507,179 | Encapsulation of active cytoskeletal protein networks in cell-sized liposomes. We demonstrate that cytoskeletal actin-myosin networks can be encapsulated with high efficiency in giant liposomes by hydration of lipids in an agarose hydrogel. The liposomes have cell-sized diameters of 10-20 μm and a uniform actin content. We show by measurements of membrane fluorescence intensity and bending rigidity that the majority of liposomes are unilamellar. We further demonstrate that the actin network can be specifically anchored to the membrane by biotin-streptavidin linkages. These protein-filled liposomes are useful model systems for quantitative studies of the physical mechanisms by which the cytoskeleton actively controls cell shape and mechanics. In a broader context, this new preparation method should be widely applicable to encapsulation of proteins and polymers, for instance, to create polymer-reinforced liposomes for drug delivery. | 12546611 |
4,507,180 | Transseptal puncture: Use of an angioplasty guidewire for enhanced safety During transseptal puncture, once the needle tip has successfully accessed the left atrium, advancement of the needle, dilator and sheath into the left atrium can risk left atrial free wall perforation, particularly if the interatrial septum is aneurysmal and tents far into the left atrial cavity during puncture. We have modified our transseptal technique such that once the left atrium is accessed with the needle tip, a 0.014″ angioplasty guidewire is advanced down the Brockenbrough needle. This is guided into the left upper pulmonary vein, and the needle, dilator and sheath advanced over this wire towards the left upper pulmonary vein. In this way, the risk of perforation of the left atrial free wall is negated. We have since used this technique in 30 cases without difficulties. © 2007 Wiley‐Liss, Inc. | 1498461 |
4,507,181 | Threshold Calibration in CLARIT Adaptive Filtering In this paper, we describe the system and methods used for the CLARITECH entries in the TREC–7 Filtering Track. Our main aim was to study algorithms, designs, and parameters for Adaptive Filtering, as this comes closest to actual applications. For efficiency's sake, however, we adapted a system largely geared towards retrieval and introduced a few critical new components. The first of these components, the delivery ratio mechanism, is used to obtain a profile threshold when no feedback has been received. A second method, which we call beta–gamma regulation, is used for threshold updating. It takes into account the number of judged documents processed by the system as well as an expected bias in optimal threshold calculation. Several parameters were determined empirically: apart from the parameters pertaining to the new components, we also experimented with different choices for the reference corpus, and different "chunk" sizes for processing news stories. Gradually increasing chunk sizes over "time" appears to help profile learning. Finally, we examined the effect of terminating underperforming queries over the AP90 corpus and found that the utility metric over AP88–AP89 was a good predictor. All of the above innovations contributed to the success of the CLARITECH system in the adaptive filtering track. | 3887661 |
4,507,182 | A radioimmunoassay for serum ferritin. We describe the development and evaluation of a serum ferritin radioimmunoassay, in which 125l-labeled ferritin and rabbit anti-ferritin antibody are used. Goat anti-rabbit gamma-globulin antibody, together with polyethylene glycol, is used as the separating reagent. The assay has a working range up to 500 mug of ferritin per litre, and a sample requirement of 75 mul of serum for assay at two dilutions. The assay requires 24 h. it has a sensitivity of 1.5 mug of ferritin per litre and a long-term precision (CV) of 13%. Reference intervals for a population of men were 18-330 mug/litre, with no marked age dependence, while those for a population of women older than 50 years were 18-200 mug/litre. Many apparently healthy women in the 20-50 year age group have much lower concentrations. Serum ferritin concentrations of less than 18 mug/litre are indicative of iron deficiency, defined as the absence of stainable iron in an aspirate of bone marrow. | 6778111 |
4,507,183 | ACUTE OCULAR INJURIES CAUSED BY 60-GHZ MILLIMETER-WAVE EXPOSURE The goal of this study was to examine the clinical course of 60-GHz millimeter-wave induced damages to the rabbit eye and to report experimental conditions that allow reproducible induction of these injuries. The eyes of pigmented rabbits (total number was 40) were irradiated with 60-GHz millimeter-waves using either a horn antenna or one of two lens antennas (6 and 9 mm diameter; ϕ6, ϕ9) Morphological changes were assessed by slit-lamp microscopy. Additional assessments included corneal fluorescein staining, iris fluorescein angiography, and lens epithelium light microscopy. Under the standardized eye-antenna positioning, the three antennas caused varying damages to the eyelids or eyeglobes. The most reproducible injuries without concurrent eyelid edema and corneal desiccation were achieved using the ϕ6 lens antenna: irradiation for 6 min led to an elevation of the corneal surface temperature (reaching 54.2 ± 0.9°C) plus corneal edema and epithelial cell loss. Furthermore, mitotic cells appeared in the pupillary area of the lens epithelium. Anterior uveitis also occurred resulting in acute miosis (from 6.6 ± 1.4 to 2.2 ± 1.4 mm), an increase in flares (from 6.7 ± 0.9 to 334.3 ± 130.8 photons per second), and iris vasodilation or vessel leakage. These findings indicate that the three types of millimeter-wave antennas can cause thermal injuries of varying types and levels. The thermal effects induced by millimeter-waves can apparently penetrate below the surface of the eye. | 5955361 |
4,507,184 | POEME: A Poetry Engine Powered by Your Movement The interactive movement installation, POEME: A Poetry Engine explores the relationship between bodily, mechanical and digital interpretations of movement. The installation grew out of our design of POEME, a mobile website that responds to movement with poetic verse. While the POEME website can be used virtually anywhere, the installation anchors the interaction to a tangible space. We reference the choreographed routines of mass transit by giving participants a virtual ticket which grants them entrance to a private performance space. The participant's movement is conveyed outside of the space in the form of measurements and poetic verse created from words that relate to mechanical theories of movement. In order to understand the relationship between these interpretations and the bodily movement that powers POEME, the audience must experience the interaction for themselves. POEME builds off prior work in body-centric, experiential design. In contrast to systems that seek to identify individual features of movement, we instead attempt to characterize and respond to whole kinesthetic experiences through poetic verse. | 10109561 |
4,507,185 | Molecular Aspect of Osteoporotic Fracture Healing Protein expression of growth factors involved in fracture healing and osteoporosis were investigated in ovariectomised (OVX) rat fracture model using histological and immunohistochemical analysis. The OVX model was confirmed by a significantly increased body weight and reduced bone density of the non-fracture hind limbs. The tissue morphology and the protein expression were assessed on the paraffin sections of the fracture callus at day 7, 14, 28 and 42 after fracture. Histology revealed a significantly higher ratio of fibrous tissue over bone or cartilage over bone in the fracture callus at day 28 and 42 in the OVX rats than in the normal rats. Immunohistochemical staining of IGF-I, IGF-IRα, MMP-1, TIMP-1 and 2 showed a different pattern between the OVX and the control groups. A down-regulation of IGF-I and TIMP-1 and an up-regulation of MMP-1 were observed in OVX rats, which may account in part for the delayed healing of the osteoporotic fracture and may affect extracellular matrix composition, an important determinant of callus strength. | 136817611 |
4,507,186 | Frailty and multimorbidity: a systematic review and meta-analysis. Background Multimorbidity and frailty are complex syndromes characteristics of ageing. We reviewed the literature, and provided pooled estimations of any evidence regarding a) the coexistence of frailty and multimorbidity, and b) their association. Methods We searched PubMed and Web of Science for relevant articles up to September 2017. Pooled estimates were obtained through random effect models and Mantel-Haenszel weighting. Homogeneity (I2), risk of bias and publication bias were assessed. PROSPERO registration: 57890. Results A total of 48 studies involving 78122 participants were selected, and 25 were included in one or more meta-analyses. Forty-five studies were cross-sectional and 3 longitudinal, with the majority of them including community-dwelling participants (n=35). Forty-three studies presented a moderate risk of bias, and 5 a low risk. Most of the articles defined multimorbidity as having two or more diseases and frailty according to the Cardiovascular Health Study criteria. In meta-analyses, the prevalence of multimorbidity in frail individual was 72% (95% Confidence Interval [95% CI] 63% to 81%; I2=91.3%) and the prevalence of frailty among multimorbid individuals was 16% (95% CI 12% to 21%; I2=96.5%). Multimorbidity was associated with frailty in pooled analyses (OR 2.27; 95% CI 1.97 to 2.62; I2 47.7%). The three longitudinal studies suggest a bidirectional association between multimorbidity and frailty. Conclusions Frailty and multimorbidity are two related conditions in older adults. Most frail individuals are also multimorbid but fewer multimorbid ones present also frailty. Our findings are not conclusive regarding the causal association between the two conditions. Further longitudinal and well-designed | 19189961 |
4,507,187 | studies may help to untangle the relationship between frailty and multimorbidity. | 19189961 |
4,507,188 | Biosurfactants as green stabilizers for the biological synthesis of nanoparticles Taking into consideration the needs of greener bioprocesses and novel enhancers for synthesis using microbial processes, biosurfactants, and/or biosurfactant producing microbes are emerging as an alternate source for the rapid synthesis of nanoparticles. A microemulsion technique using an oil-water-surfactant mixture was shown to be a promising approach for nanoparticle synthesis. Biosurfactants are natural surfactants derived from microbial origin composed mostly of sugar and fatty acid moieties, they have higher biodegradability, lower toxicity, and excellent biological activities. The biosurfactant mediated process and microbial synthesis of nanoparticles are now emerging as clean, nontoxic, and environmentally acceptable “green chemistry’’ procedures. The biosurfactant-mediated synthesis is superior to the methods of bacterial- or fungal-mediated nanoparticle synthesis, since biosurfactants reduce the formation of aggregates due to the electrostatic forces of attraction and facilitate a uniform morphology of the nanoparticles. In this review, we highlight the biosurfactant mediated synthesis of nanoparticles with relevant details including a greener bioprocess, sources of biosurfactants, and biological synthesized nanoparticles based on the available literature and laboratory findings. | 21937361 |
4,507,189 | State aid 2000–2010: The UK experience The importance of state aid rules as an instrument of regional policy diminished during the period from 2000 to 2010 because European enlargement reduced the number of areas eligible for higher levels of state aid. The Lisbon Agenda led to more emphasis on horizontal pan-European aid rules, including for small and medium-sized enterprises (SMEs), but it struggled to match the USA’s more liberal approach to subsidies. This article examines the UK experience of state aid in the light of the shifting policy agenda at European Union (EU) level, but focuses also on the implications of EU state aid rules for SMEs, in particular by comparing EU with US policy. | 154600761 |
4,507,190 | Identification of adenovirus 2 early genes required for induction of cellular DNA synthesis in resting hamster cells tsAF8 cells are temperature-sensitive (ts) mutants of BHK-21 cells that arrest at the nonpermissive temperature in the G1 phase of the cell cycle. When made quiescent by serum restriction, they can be stimulated to enter the S phase by 10% serum at 34 degrees C, but not at 40.6 degrees C. Infection by adenovirus type 2 or type 5 stimulates cellular DNA synthesis in tsAF8 cells at both 34 and 40.6 degrees C. Infection of these cells with deletion Ad5dl312, Ad5dl313, Ad2 delta p305, and Ad2+D1) and temperature-sensitive (H5ts125, H5ts36) mutants of adenovirus indicates that the expression of both early regions 1A and 2 is needed to induce quiescent tsAF8 cells to enter the S phase at the permissive temperature. This finding has been confirmed by microinjection of selected adenovirus DNA fragments into the nucleus of tsAF8 cells. In addition, we have shown that additional viral functions encoded by early regions 1B and 5 are required for the induction of cellular DNA synthesis at the nonpermissive temperature. | 754711 |
4,507,191 | High efficient Pd-based bimetallic alloyed catalyst for Electroless deposition of metallic copper The ECD have been considered critical process for PCB industry, yet the catalysts with high performance are of great importance in this process. In this work, PdCu bimetallic alloyed catalyst for Electroless copper deposition (ECD) were proposed by reducing the mixed metallic precursor with a simple hydrothermal method. The tunable Pd/Cu ratio plays key role of the morphologies and the electro-catalytic activity. The as-prepared PdCu catalysts Pd1Cu1.5 exhibits enhanced activity and high mass current density (about 576mA mgPd-1) as well as high efficiency of ECD. | 33687111 |
4,507,192 | A comparison of the changes in suprathreshold apparent contrast in acute and simulated optic neuritis. A thin PVC film was used as a diffusion filter together with glass lenses in order to induce a unilateral artificial contrast sensitivity depression in controls. These artificially depressed contrast sensitivity functions were made comparable to those assessed in patients during the recovery phase of their acute unilateral optic neuritis. A technique of subjective suprathreshold contrast matching was used to determine the suprathreshold apparent contrast in patients and controls with acute and simulated optic neuritis respectively. The results showed that differences in apparent contrast between the eyes is proportional to the discrepancy in threshold contrast for high and intermediate spatial frequencies in patients with optic neuritis. For low frequencies the apparent contrast difference was independent of threshold differences. Contrast vision of controls with simulated optic neuritis did not show this frequency dependency. There was also a discrepancy in visual acuity between the two groups. Generally the control with artificially depressed contrast sensitivity functions has a letter acuity value lower than that of the optic neuritis patient with a corresponding CSF depression. | 29670261 |
4,507,193 | Periodic Mesoporous Organosilicas Containing Interconnected [Si(CH2)]3 Rings A periodic mesoporous organosilica composed of interconnected three-ring [Si(CH2)]3 units built of three SiO2(CH2)2 tetrahedral subunits is reported. It represents the archetype of a previously unknown class of nanocomposite materials in which two bridging organic groups are bound to each silicon atom. It can be obtained with powder and oriented film morphologies. The nanocomposite is self-assembled from the cyclic three-ring silsesquioxane [(EtO)2Si(CH2)]3 precursor and a surfactant mesophase to give a well-ordered mesoporous framework. Low dielectric constants and good mechanical stability of the films were measured, making this material interesting for microelectronic applications. Methylene group reactivity of the three-ring precursor provides entry to a family of nanocomposites, exemplified by the synthesis and self-assembly of [(EtO)2Si(CHR)][(EtO)2Si(CH2)]2 (where R indicates iodine, bromine, or an ethyl group). | 45552311 |
4,507,194 | Finite elements and fast iterative solvers: with applications in incompressible fluid dynamics The efficient numerical treatment of incompressible fluid dynamics is a formidable challenge in computational mathematics. To develop an efficient treatment, one needs to understand the basic equations of fluid dynamics; i.e., the Stokes and Navier–Stokes equations, together with the boundary conditions that give wellposedness. Next, for variational formulations, one needs a knowledge of finite element discretizations that are stable or finite element stabilization techniques, in order to generate accurate numerical solutions. Finally, one needs a grasp of fast iterative solution schemes, both linear and nonlinear, so that an overall efficient method can be constructed. To gain acquaintance with such a cutting-edge development, prior to the publication of this book, the main reference sources were technical journal articles on each of these treatment components. Finite Elements and Fast Iterative Solvers: with Applications in Incompressible Fluid Dynamics, by Elman, Silvester, and Wathen, now gives a thorough presentation of the state-ofthe-art techniques in one volume. The authors are acclaimed in this research field. Indeed, this book presents many of their own research results, but in a readable form accessible to a broad audience of both professionals and students of engineering, mathematics, and interdisciplinary computational science. The book is self-contained. Only basic knowledge of discretization methods for partial differential equations, fundamental functional analysis, and computational linear algebra are needed. Presentation of the basic partial differential equations underlying fluid dynamics, of finite element discretization, and of iterative linear system schemes start from the basics. The book then systematically progresses | 34092761 |
4,507,195 | to more advanced theoretical and computational techniques for incompressible fluid dynamics. These advanced topics include continuous and discrete inf-sup stability and finite elements that satisfy them, stabilized finite element techniques and the patch-test to verify stability, Krylov iterative methods and the theory behind them, construction and justification of efficient preconditioners for the Stokes and Navier–Stokes equations, and a posteriori adaptive procedures. Even though these topics are often accessible only to experts in the field, the authors give a comprehendible yet thorough presentation, with concrete test-suite examples and appropriate analytical and computational exercises to give the reader a grasp of these concepts. | 34092761 |
4,507,196 | Does the Influence of Stroke on Dementia Vary by Different Levels of Prestroke Cognitive Functioning?: A Cohort Study Background and Purpose— The association between stroke and subsequent dementia or Alzheimer disease is well established. What is less understood is the extent to which this association is dependent on prestroke cognitive functioning. The study estimated the occurrence in poststroke dementia as a function of prestroke cognitive status and incident stroke. Methods— Study data were derived from the English Longitudinal Study of Ageing, a 10-year long prospective cohort study of older adults living in England. Baseline data (2002/2003) were used to group participants into tertiles of cognitive, memory, and executive functioning before an incident stroke. Data from 4 follow-up surveys were used to identify new stroke and poststroke dementia events. Results— The analyses were based on 10 809 participants aged ≥50 years at baseline. High prestroke executive functioning was associated with lower relative risk (RR) of dementia (RR, 0.24; 95% confidence interval, 0.13–0.45; P<0.001). Stroke was associated with increased RR of poststroke dementia (RR, 2.63; 95% confidence interval, 1.80–3.84; P<0.001). The association of stroke with poststroke dementia was greater for participants with higher prestroke executive functioning (interaction term RR, 4.4; 95% confidence interval, 1.35–14.63; P=0.014). For participants with higher executive functioning, the probability of dementia was 0.3% without stroke and 3.1% after stroke, compared with 1.9% and 5.2% for lower executive functioning. Conclusions— Stroke and prestroke cognition were independently associated with increased probability of poststroke dementia. Stroke results in disproportionate increase in the risk of dementia when premorbid | 7292411 |
4,507,197 | cognitive functioning is high. | 7292411 |
4,507,198 | The missing piece: a sociological autopsy of firearm suicide in the United States. Social, economic, violence, political, and gun access predictors of suicide and gun suicide were examined via sociological autopsy. The model predicting suicide rates overall had the best results, χ(2) (9, N=50)=5.279 (CMIN, the goodness of fit statistic that represents the minimum discrepancy between the unrestricted sample covariance matrix and the restricted covariance matrix) p=.809, [the goodness of fit statistic that represents the minimum discrepancy between the unrestricted sample covariance matrix and the restricted covariance matrix] indicating an excellent fit of the data and theoretical model. The model explained 76% of the variance in state suicide rates and was a significantly better predictor than one could expect by chance, F(6,43)=22.889, p<.001). All path coefficients were significant predictors of suicide with the exception of violence climate, which was not included. This study contributes to the theoretical knowledge by adding a comprehensive framework of analysis and model useful for prevention. | 28822561 |
4,507,199 | [THE STRUCTURE OF LYMPHATIC CAPILLARIES OF THE CILIARY BODY OF THE HUMAN EYE]. Using light microscopy, immunohistochemistry and electron microscopy, the structural organization of interstitial spaces and vessels of the ciliary body of the human eye (n = 5) were studied. The ciliary body was found to contain wide interstitial spaces--tissue clefts bound by collagen fibers and fibroblasts. Organ-specific lymphatic capillaries were also demonstrated in the ciliary body. According to the present findings and the lymphatic region concept, the first 2 elements of the lymphatic region of the eye were described: tissue clefts--prelymphatics and lymphatic capillaries of the ciliary body. The third element of the lymphatic region are the lymph nodes of the head and neck. | 46005411 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.