Popular Vote (popV) model for automated cell type annotation of single-cell RNA-seq data. We provide here pretrained models for plug-in use in your own analysis. Follow our tutorial to learn how to use the model for cell type annotation.

Model description

Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. Despite rapid advances over recent years, many of the molecular and cellular processes that underlie the progressive loss of healthy physiology are poorly understood. To gain a better insight into these processes, here we generate a single-cell transcriptomic atlas across the lifespan of Mus musculus that includes data from 23 tissues and organs. We found cell-specific changes occurring across multiple cell types and organs, as well as age-related changes in the cellular composition of different organs. Using single-cell transcriptomic data, we assessed cell-type-specific manifestations of different hallmarks of ageing—such as senescence, genomic instability and changes in the immune system. This transcriptomic atlas—which we denote Tabula Muris Senis, or ‘Mouse Ageing Cell Atlas’—provides molecular information about how the most important hallmarks of ageing are reflected in a broad range of tissues and cell types.

Link to CELLxGENE: Link to the data in the CELLxGENE browser for interactive exploration of the data and download of the source data.

Training Code URL: Not provided by uploader.

Metrics

We provide here accuracies for each of the experts and the ensemble model. The validation set accuracies are computed on a 10% random subset of the data that was not used for training.

Cell Type N cells celltypist knn bbknn knn harmony knn on scvi onclass scanvi svm xgboost Consensus Prediction
microglial cell 1336 0.99 0.99 0.96 0.99 0.00 0.96 0.99 0.99 0.99
B cell 555 0.65 0.71 0.72 0.68 0.00 0.71 0.65 0.70 0.77
endothelial cell 482 0.79 0.84 0.80 0.70 0.00 0.70 0.86 0.82 0.89
mesenchymal stem cell of adipose tissue 455 0.84 0.89 0.75 0.65 0.00 0.65 0.93 0.86 0.90
basal cell of epidermis 406 0.87 0.91 0.84 0.86 0.00 0.81 0.93 0.89 0.93
fibroblast of cardiac tissue 342 0.93 0.93 0.73 0.63 0.00 0.19 0.97 0.93 0.95
hematopoietic stem cell 312 0.95 0.95 0.94 0.95 0.00 0.94 0.98 0.96 0.97
granulocyte 294 0.89 0.91 0.89 0.86 0.00 0.71 0.92 0.91 0.93
naive B cell 334 0.46 0.09 0.54 0.41 0.00 0.19 0.58 0.65 0.41
skeletal muscle satellite cell 278 0.98 0.98 0.95 0.95 0.00 0.95 0.97 0.96 0.98
endothelial cell of coronary artery 263 0.78 0.81 0.63 0.43 0.00 0.64 0.89 0.83 0.90
keratinocyte stem cell 255 0.93 0.93 0.95 0.93 0.00 0.93 0.97 0.94 0.96
myeloid cell 240 0.51 0.67 0.51 0.46 0.00 0.53 0.68 0.67 0.69
enterocyte of epithelium of large intestine 269 0.91 0.93 0.88 0.94 0.00 0.94 0.94 0.91 0.94
macrophage 251 0.35 0.52 0.44 0.46 0.00 0.34 0.51 0.55 0.59
basal cell 206 1.00 0.99 0.97 0.94 0.00 0.95 0.99 0.98 0.99
bronchial smooth muscle cell 208 0.95 0.95 0.85 0.71 0.00 0.89 0.95 0.96 0.96
oligodendrocyte 221 0.99 1.00 0.99 1.00 0.00 0.99 1.00 0.99 1.00
DN4 thymocyte 166 0.61 0.62 0.42 0.53 0.00 0.52 0.77 0.75 0.75
epithelial cell of large intestine 172 0.89 0.88 0.72 0.83 0.00 0.86 0.93 0.91 0.91
thymocyte 150 0.89 0.91 0.74 0.83 0.00 0.84 0.91 0.92 0.92
large intestine goblet cell 168 0.80 0.85 0.81 0.82 0.00 0.81 0.91 0.89 0.90
intestinal crypt stem cell 155 0.86 0.90 0.81 0.87 0.00 0.89 0.94 0.89 0.93
mesenchymal stem cell 176 0.70 0.80 0.59 0.47 0.00 0.53 0.89 0.81 0.86
bladder urothelial cell 124 0.97 0.96 0.92 0.90 0.00 0.93 0.99 0.99 0.98
type B pancreatic cell 129 0.99 0.98 0.93 0.97 0.00 0.98 0.99 0.98 0.99
fibroblast 136 0.51 0.65 0.31 0.37 0.00 0.34 0.87 0.71 0.74
T cell 101 0.33 0.39 0.38 0.30 0.00 0.37 0.44 0.47 0.45
monocyte 115 0.55 0.72 0.52 0.57 0.00 0.46 0.77 0.75 0.80
keratinocyte 130 0.81 0.90 0.71 0.74 0.00 0.78 0.94 0.87 0.93
CD4-positive, alpha-beta T cell 142 0.57 0.64 0.49 0.45 0.00 0.55 0.58 0.63 0.70
hepatocyte 102 0.96 0.96 0.97 0.94 0.00 0.95 0.97 0.95 0.97
CD8-positive, alpha-beta T cell 111 0.52 0.47 0.48 0.46 0.00 0.54 0.51 0.58 0.59
promonocyte 98 0.48 0.69 0.61 0.46 0.00 0.53 0.72 0.73 0.76
bladder cell 88 0.99 0.99 0.90 0.64 0.00 0.81 1.00 0.96 0.99
natural killer cell 96 0.78 0.76 0.70 0.60 0.00 0.71 0.71 0.72 0.79
precursor B cell 86 0.84 0.87 0.68 0.73 0.00 0.84 0.89 0.88 0.90
luminal epithelial cell of mammary gland 80 0.92 0.95 0.94 0.91 0.00 0.90 0.97 0.96 0.96
endothelial cell of hepatic sinusoid 59 0.93 0.97 0.90 0.81 0.00 0.88 0.93 0.93 0.94
astrocyte 53 0.85 0.94 0.88 0.92 0.00 0.95 0.94 0.93 0.95
immature B cell 48 0.63 0.52 0.39 0.27 0.00 0.46 0.60 0.56 0.71
pancreatic acinar cell 58 0.97 0.97 0.97 0.95 0.00 0.98 1.00 1.00 1.00
secretory cell 61 0.68 0.56 0.42 0.45 0.00 0.67 0.86 0.84 0.80
pancreatic A cell 67 0.88 0.92 0.86 0.90 0.00 0.94 0.96 0.95 0.94
epidermal cell 59 0.82 0.79 0.39 0.69 0.00 0.69 0.84 0.76 0.83
neuron 37 0.65 0.68 0.60 0.68 0.00 0.85 0.92 0.82 0.86
brain pericyte 40 0.79 0.83 0.73 0.74 0.00 0.91 0.95 0.88 0.86
granulocytopoietic cell 46 0.75 0.86 0.76 0.85 0.00 0.78 0.86 0.80 0.83
fibroblast of lung 48 0.95 0.95 0.93 0.92 0.00 0.93 0.97 0.95 0.97
kidney collecting duct epithelial cell 33 0.61 0.86 0.85 0.79 0.00 0.98 0.99 0.99 0.98
aortic endothelial cell 9 0.00 0.00 0.00 0.00 0.00 0.14 0.11 0.08 0.09
epithelial cell 34 0.31 0.11 0.43 0.41 0.00 0.37 0.54 0.48 0.59
late pro-B cell 38 0.88 0.94 0.93 0.84 0.00 0.91 0.96 0.92 0.97
basal epithelial cell of tracheobronchial tree 34 0.62 0.51 0.42 0.61 0.00 0.67 0.89 0.80 0.88
regular atrial cardiac myocyte 39 0.45 0.64 0.73 0.61 0.00 0.58 0.76 0.77 0.80
epithelial cell of proximal tubule 33 0.35 0.78 0.69 0.71 0.00 0.91 0.96 0.97 0.93
endocardial cell 38 0.96 0.95 0.93 0.80 0.00 0.82 0.97 0.96 0.99
myeloid dendritic cell 39 0.48 0.57 0.12 0.33 0.00 0.44 0.75 0.70 0.68
stromal cell 25 0.26 0.35 0.20 0.29 0.00 0.36 0.58 0.58 0.62
mature alpha-beta T cell 32 0.22 0.15 0.09 0.31 0.00 0.36 0.36 0.49 0.26
cardiac valve cell 33 0.78 0.85 0.78 0.81 0.00 0.88 0.90 0.86 0.85
pancreatic ductal cell 34 1.00 0.99 0.99 0.96 0.00 0.99 1.00 1.00 1.00
oligodendrocyte precursor cell 36 0.97 0.99 0.93 0.93 0.00 1.00 0.99 0.94 0.99
adventitial cell 41 0.48 0.40 0.31 0.10 0.00 0.27 0.79 0.55 0.69
chondrocyte 23 0.73 0.79 0.81 0.67 0.00 0.81 0.89 0.85 0.83
Kupffer cell 38 0.99 0.93 0.84 0.85 0.00 0.80 0.97 0.92 0.97
granulocyte monocyte progenitor cell 21 0.65 0.78 0.81 0.68 0.00 0.79 0.84 0.86 0.88
interneuron 25 0.49 0.67 0.47 0.60 0.00 0.89 0.96 0.89 0.88
myeloid leukocyte 17 0.00 0.21 0.38 0.29 0.00 0.06 0.20 0.50 0.20
classical monocyte 13 0.00 0.27 0.28 0.22 0.00 0.36 0.62 0.57 0.53
mature NK T cell 19 0.40 0.17 0.26 0.16 0.00 0.46 0.33 0.68 0.58
pancreatic D cell 17 0.94 0.90 0.82 0.94 0.00 0.92 1.00 1.00 1.00
brush cell of epithelium proper of large intestine 15 0.76 0.73 0.33 0.74 0.00 0.64 0.94 0.88 0.90
epithelial cell of thymus 19 0.10 0.00 0.18 0.55 0.00 0.46 0.56 0.49 0.53
enteroendocrine cell 11 0.95 0.62 0.53 0.86 0.00 0.81 0.90 1.00 0.95
leukocyte 16 0.00 0.61 0.40 0.00 0.00 0.06 0.75 0.81 0.67
neutrophil 12 0.00 0.00 0.00 0.00 0.00 0.18 0.42 0.40 0.11
vein endothelial cell 13 0.43 0.27 0.20 0.12 0.00 0.78 1.00 0.74 0.70
kidney collecting duct principal cell 11 0.00 0.86 0.73 0.78 0.00 0.87 0.91 0.83 0.95
neuroepithelial stem cell 22 0.32 0.09 0.43 0.50 0.00 0.62 0.83 0.74 0.84
non-classical monocyte 16 0.00 0.55 0.33 0.22 0.00 0.46 0.67 0.72 0.59
regular ventricular cardiac myocyte 16 0.43 0.00 0.81 0.80 0.00 0.82 1.00 0.94 0.86
kidney loop of Henle ascending limb epithelial cell 12 0.63 0.85 0.77 0.80 0.00 0.96 0.96 0.87 0.92
smooth muscle cell of trachea 11 0.00 0.00 0.21 0.27 0.00 0.29 0.52 0.46 0.40
professional antigen presenting cell 2 0.00 0.00 0.14 0.50 0.00 0.33 0.36 0.21 0.50
smooth muscle cell of the pulmonary artery 6 0.00 0.44 0.00 0.33 0.00 0.27 0.83 0.77 0.91
proerythroblast 10 0.00 0.40 0.24 0.31 0.00 0.17 0.30 0.40 0.12
smooth muscle cell 14 0.00 0.58 0.33 0.24 0.00 0.67 0.93 0.84 0.77
medium spiny neuron 11 1.00 0.95 0.40 0.86 0.00 0.96 1.00 1.00 1.00
endothelial cell of lymphatic vessel 7 0.47 0.46 0.83 0.22 0.00 0.52 0.88 0.64 0.82
neural stem cell 14 0.00 0.80 0.72 0.64 0.00 0.79 0.89 0.75 0.85
mesangial cell 8 0.00 0.40 0.00 0.00 0.00 0.21 0.43 0.56 0.55
megakaryocyte-erythroid progenitor cell 10 0.32 0.40 0.40 0.57 0.00 0.55 0.57 0.67 0.64
mucus secreting cell 9 0.64 0.55 0.71 0.62 0.00 0.89 0.95 1.00 0.90
early pro-B cell 7 0.00 0.83 0.83 0.86 0.00 0.86 0.86 0.80 0.92
pancreatic PP cell 8 0.00 0.40 0.22 0.20 0.00 0.71 0.88 0.80 0.40
basophil 11 0.27 0.43 0.84 0.64 0.00 0.69 0.95 0.82 0.87
ciliated columnar cell of tracheobronchial tree 9 0.62 0.84 0.88 0.82 0.00 0.82 0.90 0.82 0.95
dendritic cell 8 0.44 0.29 0.00 0.42 0.00 0.31 0.59 0.47 0.42
ependymal cell 6 0.00 0.60 0.67 0.92 0.00 0.80 1.00 0.92 1.00
Bergmann glial cell 2 0.00 0.67 0.67 0.50 0.00 0.50 0.50 0.50 0.67
pulmonary interstitial fibroblast 4 0.38 0.50 0.50 0.75 0.00 0.67 0.86 0.67 0.67
pancreatic stellate cell 3 0.67 0.67 0.67 0.00 0.00 0.18 0.67 0.57 0.67
regulatory T cell 4 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pericyte 4 0.00 0.67 0.75 0.67 0.00 0.67 0.75 0.89 0.75
fibrocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
respiratory basal cell 6 0.00 0.00 0.00 0.67 0.00 0.56 0.80 0.91 0.67
plasma cell 2 0.17 0.00 0.00 0.00 0.00 0.22 0.00 0.36 0.36
club cell 2 0.00 0.00 0.10 0.20 0.00 0.11 0.67 0.29 0.40
kidney interstitial fibroblast 1 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 0.00
lymphoid lineage restricted progenitor cell 2 0.00 0.00 0.67 1.00 0.00 0.80 0.67 0.67 0.67
intermediate monocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
lymphocyte 1 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
lung macrophage 1 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
plasmacytoid dendritic cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
lung neuroendocrine cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00

The train accuracies are computed on the training data.

Cell Type N cells celltypist knn bbknn knn harmony knn on scvi onclass scanvi svm xgboost Consensus Prediction
microglial cell 11932 0.99 0.99 0.95 0.99 0.00 0.97 0.99 0.99 1.00
B cell 5056 0.64 0.71 0.82 0.78 0.00 0.93 0.69 0.73 0.86
endothelial cell 4433 0.79 0.79 0.85 0.78 0.00 0.81 0.87 0.84 0.92
mesenchymal stem cell of adipose tissue 4275 0.85 0.88 0.81 0.76 0.00 0.97 0.94 0.88 0.96
basal cell of epidermis 3808 0.84 0.89 0.92 0.90 0.00 0.81 0.93 0.91 0.93
fibroblast of cardiac tissue 3575 0.92 0.91 0.81 0.78 0.00 0.96 0.95 0.92 0.96
hematopoietic stem cell 2994 0.93 0.94 0.96 0.96 0.00 0.96 0.97 0.96 0.97
granulocyte 2672 0.89 0.91 0.90 0.92 0.00 0.94 0.95 0.94 0.96
naive B cell 2625 0.38 0.02 0.75 0.61 0.00 0.92 0.61 0.66 0.73
skeletal muscle satellite cell 2441 0.97 0.97 0.91 0.98 0.00 0.97 0.98 0.97 0.98
endothelial cell of coronary artery 2431 0.76 0.75 0.81 0.63 0.00 0.87 0.91 0.87 0.95
keratinocyte stem cell 2384 0.94 0.94 0.96 0.95 0.00 0.95 0.97 0.95 0.97
myeloid cell 2307 0.52 0.66 0.70 0.66 0.00 0.82 0.77 0.78 0.85
enterocyte of epithelium of large intestine 2273 0.91 0.94 0.95 0.95 0.00 0.94 0.95 0.94 0.96
macrophage 2192 0.33 0.48 0.72 0.63 0.00 0.67 0.60 0.66 0.72
basal cell 1933 0.99 0.98 0.98 0.96 0.00 0.97 0.99 0.99 0.99
bronchial smooth muscle cell 1907 0.94 0.93 0.81 0.77 0.00 0.94 0.98 0.96 0.97
oligodendrocyte 1873 0.98 0.99 0.98 1.00 0.00 0.99 1.00 0.99 0.99
DN4 thymocyte 1590 0.59 0.56 0.66 0.69 0.00 0.92 0.86 0.86 0.88
epithelial cell of large intestine 1532 0.88 0.88 0.87 0.88 0.00 0.89 0.95 0.93 0.94
thymocyte 1475 0.88 0.90 0.80 0.92 0.00 0.93 0.95 0.96 0.95
large intestine goblet cell 1419 0.78 0.83 0.89 0.88 0.00 0.92 0.96 0.93 0.95
intestinal crypt stem cell 1424 0.87 0.90 0.91 0.91 0.00 0.90 0.95 0.91 0.95
mesenchymal stem cell 1250 0.64 0.68 0.65 0.60 0.00 0.92 0.89 0.84 0.91
bladder urothelial cell 1278 0.98 0.94 0.95 0.94 0.00 0.98 0.99 0.99 0.99
type B pancreatic cell 1213 0.96 0.96 0.90 0.96 0.00 0.97 0.98 0.98 0.97
fibroblast 1193 0.48 0.54 0.60 0.54 0.00 0.96 0.92 0.83 0.92
T cell 1218 0.49 0.52 0.60 0.59 0.00 0.71 0.74 0.77 0.74
monocyte 1165 0.60 0.72 0.83 0.73 0.00 0.82 0.86 0.84 0.91
keratinocyte 1084 0.76 0.88 0.91 0.83 0.00 0.78 0.93 0.90 0.92
CD4-positive, alpha-beta T cell 1028 0.54 0.54 0.66 0.60 0.00 0.72 0.73 0.79 0.78
hepatocyte 1047 0.96 0.95 0.95 0.96 0.00 0.96 0.98 0.98 0.98
CD8-positive, alpha-beta T cell 959 0.49 0.51 0.62 0.59 0.00 0.74 0.75 0.78 0.76
promonocyte 917 0.45 0.60 0.93 0.61 0.00 0.95 0.87 0.87 0.95
bladder cell 914 0.98 0.98 0.91 0.80 0.00 0.99 1.00 0.96 1.00
natural killer cell 779 0.75 0.75 0.75 0.73 0.00 0.80 0.88 0.90 0.88
precursor B cell 770 0.83 0.85 0.87 0.80 0.00 0.90 0.96 0.95 0.94
luminal epithelial cell of mammary gland 688 0.95 0.96 0.99 0.97 0.00 0.95 1.00 0.98 0.99
endothelial cell of hepatic sinusoid 558 0.94 0.85 0.90 0.84 0.00 0.92 0.99 0.98 0.99
astrocyte 539 0.86 0.93 0.95 0.95 0.00 0.97 0.99 0.99 0.98
immature B cell 541 0.64 0.55 0.63 0.54 0.00 0.80 0.79 0.79 0.87
pancreatic acinar cell 518 0.92 0.94 0.94 0.94 0.00 0.97 0.99 0.99 0.98
secretory cell 502 0.64 0.28 0.78 0.71 0.00 0.86 0.95 0.91 0.93
pancreatic A cell 454 0.83 0.82 0.87 0.87 0.00 0.92 0.97 0.96 0.91
epidermal cell 433 0.72 0.67 0.78 0.77 0.00 0.65 0.84 0.82 0.83
neuron 447 0.69 0.66 0.72 0.80 0.00 0.91 0.98 0.97 0.95
brain pericyte 444 0.79 0.80 0.82 0.83 0.00 0.94 1.00 0.98 0.92
granulocytopoietic cell 437 0.78 0.87 0.90 0.89 0.00 0.81 0.93 0.92 0.94
fibroblast of lung 431 0.96 0.96 0.88 0.88 0.00 0.98 0.99 0.97 0.99
kidney collecting duct epithelial cell 407 0.65 0.81 0.88 0.81 0.00 0.96 1.00 0.99 0.97
aortic endothelial cell 420 0.21 0.02 0.39 0.40 0.00 0.67 0.55 0.49 0.82
epithelial cell 392 0.30 0.04 0.72 0.64 0.00 0.76 0.72 0.74 0.82
late pro-B cell 373 0.84 0.91 0.93 0.86 0.00 0.94 0.99 0.98 0.97
basal epithelial cell of tracheobronchial tree 367 0.69 0.53 0.80 0.69 0.00 0.88 0.95 0.88 0.94
regular atrial cardiac myocyte 360 0.54 0.60 0.81 0.72 0.00 0.74 0.81 0.88 0.91
epithelial cell of proximal tubule 349 0.39 0.77 0.87 0.77 0.00 0.95 0.99 0.99 0.96
endocardial cell 337 0.96 0.93 0.96 0.83 0.00 0.93 0.96 0.95 0.97
myeloid dendritic cell 334 0.45 0.47 0.86 0.58 0.00 0.91 0.89 0.82 0.88
stromal cell 315 0.24 0.19 0.62 0.47 0.00 0.94 0.76 0.68 0.92
mature alpha-beta T cell 298 0.32 0.19 0.60 0.48 0.00 0.80 0.74 0.86 0.83
cardiac valve cell 282 0.86 0.91 0.81 0.88 0.00 0.95 0.96 0.97 0.94
pancreatic ductal cell 279 0.98 0.97 0.99 0.94 0.00 0.98 0.99 0.99 0.99
oligodendrocyte precursor cell 276 0.96 0.98 0.95 0.98 0.00 0.99 1.00 1.00 1.00
adventitial cell 247 0.48 0.52 0.72 0.30 0.00 0.89 0.89 0.73 0.95
chondrocyte 252 0.87 0.80 0.91 0.82 0.00 0.89 0.98 0.95 0.95
Kupffer cell 224 0.94 0.64 0.88 0.82 0.00 0.75 0.98 0.97 0.99
granulocyte monocyte progenitor cell 229 0.62 0.78 0.87 0.86 0.00 0.83 0.90 0.89 0.91
interneuron 215 0.55 0.68 0.82 0.76 0.00 0.89 0.98 0.94 0.90
myeloid leukocyte 192 0.00 0.11 0.82 0.40 0.00 0.87 0.91 0.89 0.97
classical monocyte 189 0.00 0.34 0.64 0.53 0.00 0.90 0.87 0.86 0.92
mature NK T cell 180 0.35 0.14 0.66 0.38 0.00 0.72 0.91 0.92 0.91
pancreatic D cell 174 0.90 0.89 0.87 0.89 0.00 0.91 0.99 0.98 0.96
brush cell of epithelium proper of large intestine 160 0.76 0.76 0.77 0.81 0.00 0.85 0.98 0.97 0.94
epithelial cell of thymus 146 0.22 0.01 0.58 0.50 0.00 0.76 0.89 0.78 0.93
enteroendocrine cell 150 0.88 0.53 0.76 0.89 0.00 0.91 0.99 0.98 0.98
leukocyte 142 0.00 0.31 0.71 0.44 0.00 0.74 0.81 0.85 0.95
neutrophil 141 0.00 0.10 0.28 0.21 0.00 0.80 0.75 0.69 0.80
vein endothelial cell 139 0.53 0.54 0.71 0.30 0.00 0.88 0.95 0.89 0.85
kidney collecting duct principal cell 140 0.00 0.78 0.88 0.75 0.00 0.96 0.99 0.96 0.98
neuroepithelial stem cell 129 0.21 0.03 0.84 0.73 0.00 0.73 0.91 0.83 0.93
non-classical monocyte 133 0.00 0.36 0.59 0.38 0.00 0.83 0.81 0.77 0.89
regular ventricular cardiac myocyte 129 0.53 0.00 0.87 0.84 0.00 0.91 0.98 0.98 0.98
kidney loop of Henle ascending limb epithelial cell 132 0.65 0.85 0.92 0.69 0.00 0.96 1.00 0.99 0.99
smooth muscle cell of trachea 114 0.00 0.11 0.58 0.52 0.00 0.85 0.85 0.77 0.84
professional antigen presenting cell 114 0.14 0.15 0.53 0.61 0.00 0.84 0.87 0.80 0.93
smooth muscle cell of the pulmonary artery 105 0.00 0.55 0.77 0.40 0.00 0.53 0.89 0.83 0.91
proerythroblast 97 0.00 0.10 0.62 0.28 0.00 0.76 0.92 0.87 0.89
smooth muscle cell 89 0.00 0.34 0.67 0.42 0.00 0.95 0.97 0.92 0.91
medium spiny neuron 92 0.98 0.54 0.83 0.88 0.00 0.94 1.00 0.99 0.99
endothelial cell of lymphatic vessel 92 0.47 0.41 0.93 0.55 0.00 0.63 0.81 0.72 0.85
neural stem cell 83 0.00 0.75 0.83 0.94 0.00 0.93 1.00 0.95 0.99
mesangial cell 84 0.00 0.16 0.61 0.39 0.00 0.79 0.86 0.68 0.91
megakaryocyte-erythroid progenitor cell 70 0.30 0.27 0.80 0.82 0.00 0.81 0.89 0.96 0.94
mucus secreting cell 64 0.57 0.64 0.86 0.82 0.00 0.96 0.95 0.98 0.98
early pro-B cell 65 0.00 0.69 0.70 0.79 0.00 0.92 0.99 0.99 0.94
pancreatic PP cell 63 0.00 0.17 0.67 0.35 0.00 0.90 0.99 0.98 0.82
basophil 60 0.28 0.61 0.76 0.81 0.00 0.75 0.97 0.82 0.85
ciliated columnar cell of tracheobronchial tree 61 0.80 0.87 0.96 0.86 0.00 0.88 0.99 0.93 0.98
dendritic cell 54 0.45 0.26 0.77 0.64 0.00 0.91 0.91 0.84 0.81
ependymal cell 49 0.00 0.70 0.97 0.85 0.00 0.95 1.00 1.00 0.98
Bergmann glial cell 52 0.00 0.45 0.86 0.76 0.00 0.77 1.00 1.00 0.96
pulmonary interstitial fibroblast 45 0.41 0.59 0.76 0.74 0.00 0.92 1.00 0.94 0.95
pancreatic stellate cell 45 0.88 0.47 0.93 0.48 0.00 0.86 0.90 0.89 0.95
regulatory T cell 43 0.00 0.00 0.12 0.04 0.00 0.68 0.90 0.91 0.44
pericyte 34 0.00 0.77 0.72 0.82 0.00 0.84 0.96 0.94 0.93
fibrocyte 35 0.00 0.00 0.40 0.41 0.00 0.60 0.76 0.82 0.87
respiratory basal cell 28 0.00 0.00 0.89 0.74 0.00 0.68 0.95 0.98 0.96
plasma cell 23 0.16 0.00 0.75 0.16 0.00 0.25 0.45 0.36 0.43
club cell 20 0.00 0.00 0.22 0.17 0.00 0.26 0.91 0.44 0.57
kidney interstitial fibroblast 15 0.00 0.00 0.64 0.85 0.00 0.83 0.86 0.97 1.00
lymphoid lineage restricted progenitor cell 11 0.00 0.00 0.90 0.91 0.00 0.69 0.63 1.00 0.95
intermediate monocyte 12 0.00 0.00 0.25 0.13 0.00 0.91 1.00 1.00 0.50
lymphocyte 9 0.00 0.00 0.20 0.00 0.00 0.76 1.00 1.00 0.20
lung macrophage 8 0.00 0.00 0.22 0.00 0.00 0.44 0.89 0.80 0.93
plasmacytoid dendritic cell 6 0.00 0.00 0.00 0.00 0.00 0.63 0.43 0.86 0.67
lung neuroendocrine cell 4 0.00 0.00 0.86 0.86 0.00 1.00 0.89 1.00 0.86

References

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse, The Tabula Muris Consortium, Nicole Almanzar, Jane Antony, Ankit S. Baghel, Isaac Bakerman, Ishita Bansal, Ben A. Barres, Philip A. Beachy, Daniela Berdnik, Biter Bilen, Douglas Brownfield, Corey Cain, Charles K. F. Chan, Michelle B. Chen, Michael F. Clarke, Stephanie D. Conley, Spyros Darmanis, Aaron Demers, Kubilay Demir, Antoine de Morree, Tessa Divita, Haley du Bois, Hamid Ebadi, F. Hernán Espinoza, Matt Fish, Qiang Gan, Benson M. George, Astrid Gillich, Rafael Gòmez-Sjöberg, Foad Green, Geraldine Genetiano, Xueying Gu, Gunsagar S. Gulati, Oliver Hahn, Michael Seamus Haney, Yan Hang, Lincoln Harris, Mu He, Shayan Hosseinzadeh, Albin Huang, Kerwyn Casey Huang, Tal Iram, Taichi Isobe, Feather Ives, Robert C. Jones, Kevin S. Kao, Jim Karkanias, Guruswamy Karnam, Andreas Keller, Aaron M. Kershner, Nathalie Khoury, Seung K. Kim, Bernhard M. Kiss, William Kong, Mark A. Krasnow, Maya E. Kumar, Christin S. Kuo, Jonathan Lam, Davis P. Lee, Song E. Lee, Benoit Lehallier, Olivia Leventhal, Guang Li, Qingyun Li, Ling Liu, Annie Lo, Wan-Jin Lu, Maria F. Lugo-Fagundo, Anoop Manjunath, Andrew P. May, Ashley Maynard, Aaron McGeever, Marina McKay, M. Windy McNerney, Bryan Merrill, Ross J. Metzger, Marco Mignardi, Dullei Min, Ahmad N. Nabhan, Norma F. Neff, Katharine M. Ng, Patricia K. Nguyen, Joseph Noh, Roel Nusse, Róbert Pálovics, Rasika Patkar, Weng Chuan Peng, Lolita Penland, Angela Oliveira Pisco, Katherine Pollard, Robert Puccinelli, Zhen Qi, Stephen R. Quake, Thomas A. Rando, Eric J. Rulifson, Nicholas Schaum, Joe M. Segal, Shaheen S. Sikandar, Rahul Sinha, Rene V. Sit, Justin Sonnenburg, Daniel Staehli, Krzysztof Szade, Michelle Tan, Weilun Tan, Cristina Tato, Krissie Tellez, Laughing Bear Torrez Dulgeroff, Kyle J. Travaglini, Carolina Tropini, Margaret Tsui, Lucas Waldburger, Bruce M. Wang, Linda J. van Weele, Kenneth Weinberg, Irving L. Weissman, Michael N. Wosczyna, Sean M. Wu, Tony Wyss-Coray, Jinyi Xiang, Soso Xue, Kevin A. Yamauchi, Andrew C. Yang, Lakshmi P. Yerra, Justin Youngyunpipatkul, Brian Yu, Fabio Zanini, Macy E. Zardeneta, Alexander Zee, Chunyu Zhao, Fan Zhang, Hui Zhang, Martin Jinye Zhang, Lu Zhou, James Zou; Nature, doi: https://doi.org/10.1038/s41586-020-2496-1

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