Popular Vote (popV) model for automated cell type annotation of single-cell RNA-seq data. We provide here pretrained models for plug-in use in your own analysis. Follow our tutorial to learn how to use the model for cell type annotation.
Model description
Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. Despite rapid advances over recent years, many of the molecular and cellular processes that underlie the progressive loss of healthy physiology are poorly understood. To gain a better insight into these processes, here we generate a single-cell transcriptomic atlas across the lifespan of Mus musculus that includes data from 23 tissues and organs. We found cell-specific changes occurring across multiple cell types and organs, as well as age-related changes in the cellular composition of different organs. Using single-cell transcriptomic data, we assessed cell-type-specific manifestations of different hallmarks of ageing—such as senescence, genomic instability and changes in the immune system. This transcriptomic atlas—which we denote Tabula Muris Senis, or ‘Mouse Ageing Cell Atlas’—provides molecular information about how the most important hallmarks of ageing are reflected in a broad range of tissues and cell types.
Link to CELLxGENE: Link to the data in the CELLxGENE browser for interactive exploration of the data and download of the source data.
Training Code URL: Not provided by uploader.
Metrics
We provide here accuracies for each of the experts and the ensemble model. The validation set accuracies are computed on a 10% random subset of the data that was not used for training.
Cell Type | N cells | celltypist | knn bbknn | knn harmony | knn on scvi | onclass | scanvi | svm | xgboost | Consensus Prediction |
---|---|---|---|---|---|---|---|---|---|---|
microglial cell | 1336 | 0.99 | 0.99 | 0.96 | 0.99 | 0.00 | 0.96 | 0.99 | 0.99 | 0.99 |
B cell | 555 | 0.65 | 0.71 | 0.72 | 0.68 | 0.00 | 0.71 | 0.65 | 0.70 | 0.77 |
endothelial cell | 482 | 0.79 | 0.84 | 0.80 | 0.70 | 0.00 | 0.70 | 0.86 | 0.82 | 0.89 |
mesenchymal stem cell of adipose tissue | 455 | 0.84 | 0.89 | 0.75 | 0.65 | 0.00 | 0.65 | 0.93 | 0.86 | 0.90 |
basal cell of epidermis | 406 | 0.87 | 0.91 | 0.84 | 0.86 | 0.00 | 0.81 | 0.93 | 0.89 | 0.93 |
fibroblast of cardiac tissue | 342 | 0.93 | 0.93 | 0.73 | 0.63 | 0.00 | 0.19 | 0.97 | 0.93 | 0.95 |
hematopoietic stem cell | 312 | 0.95 | 0.95 | 0.94 | 0.95 | 0.00 | 0.94 | 0.98 | 0.96 | 0.97 |
granulocyte | 294 | 0.89 | 0.91 | 0.89 | 0.86 | 0.00 | 0.71 | 0.92 | 0.91 | 0.93 |
naive B cell | 334 | 0.46 | 0.09 | 0.54 | 0.41 | 0.00 | 0.19 | 0.58 | 0.65 | 0.41 |
skeletal muscle satellite cell | 278 | 0.98 | 0.98 | 0.95 | 0.95 | 0.00 | 0.95 | 0.97 | 0.96 | 0.98 |
endothelial cell of coronary artery | 263 | 0.78 | 0.81 | 0.63 | 0.43 | 0.00 | 0.64 | 0.89 | 0.83 | 0.90 |
keratinocyte stem cell | 255 | 0.93 | 0.93 | 0.95 | 0.93 | 0.00 | 0.93 | 0.97 | 0.94 | 0.96 |
myeloid cell | 240 | 0.51 | 0.67 | 0.51 | 0.46 | 0.00 | 0.53 | 0.68 | 0.67 | 0.69 |
enterocyte of epithelium of large intestine | 269 | 0.91 | 0.93 | 0.88 | 0.94 | 0.00 | 0.94 | 0.94 | 0.91 | 0.94 |
macrophage | 251 | 0.35 | 0.52 | 0.44 | 0.46 | 0.00 | 0.34 | 0.51 | 0.55 | 0.59 |
basal cell | 206 | 1.00 | 0.99 | 0.97 | 0.94 | 0.00 | 0.95 | 0.99 | 0.98 | 0.99 |
bronchial smooth muscle cell | 208 | 0.95 | 0.95 | 0.85 | 0.71 | 0.00 | 0.89 | 0.95 | 0.96 | 0.96 |
oligodendrocyte | 221 | 0.99 | 1.00 | 0.99 | 1.00 | 0.00 | 0.99 | 1.00 | 0.99 | 1.00 |
DN4 thymocyte | 166 | 0.61 | 0.62 | 0.42 | 0.53 | 0.00 | 0.52 | 0.77 | 0.75 | 0.75 |
epithelial cell of large intestine | 172 | 0.89 | 0.88 | 0.72 | 0.83 | 0.00 | 0.86 | 0.93 | 0.91 | 0.91 |
thymocyte | 150 | 0.89 | 0.91 | 0.74 | 0.83 | 0.00 | 0.84 | 0.91 | 0.92 | 0.92 |
large intestine goblet cell | 168 | 0.80 | 0.85 | 0.81 | 0.82 | 0.00 | 0.81 | 0.91 | 0.89 | 0.90 |
intestinal crypt stem cell | 155 | 0.86 | 0.90 | 0.81 | 0.87 | 0.00 | 0.89 | 0.94 | 0.89 | 0.93 |
mesenchymal stem cell | 176 | 0.70 | 0.80 | 0.59 | 0.47 | 0.00 | 0.53 | 0.89 | 0.81 | 0.86 |
bladder urothelial cell | 124 | 0.97 | 0.96 | 0.92 | 0.90 | 0.00 | 0.93 | 0.99 | 0.99 | 0.98 |
type B pancreatic cell | 129 | 0.99 | 0.98 | 0.93 | 0.97 | 0.00 | 0.98 | 0.99 | 0.98 | 0.99 |
fibroblast | 136 | 0.51 | 0.65 | 0.31 | 0.37 | 0.00 | 0.34 | 0.87 | 0.71 | 0.74 |
T cell | 101 | 0.33 | 0.39 | 0.38 | 0.30 | 0.00 | 0.37 | 0.44 | 0.47 | 0.45 |
monocyte | 115 | 0.55 | 0.72 | 0.52 | 0.57 | 0.00 | 0.46 | 0.77 | 0.75 | 0.80 |
keratinocyte | 130 | 0.81 | 0.90 | 0.71 | 0.74 | 0.00 | 0.78 | 0.94 | 0.87 | 0.93 |
CD4-positive, alpha-beta T cell | 142 | 0.57 | 0.64 | 0.49 | 0.45 | 0.00 | 0.55 | 0.58 | 0.63 | 0.70 |
hepatocyte | 102 | 0.96 | 0.96 | 0.97 | 0.94 | 0.00 | 0.95 | 0.97 | 0.95 | 0.97 |
CD8-positive, alpha-beta T cell | 111 | 0.52 | 0.47 | 0.48 | 0.46 | 0.00 | 0.54 | 0.51 | 0.58 | 0.59 |
promonocyte | 98 | 0.48 | 0.69 | 0.61 | 0.46 | 0.00 | 0.53 | 0.72 | 0.73 | 0.76 |
bladder cell | 88 | 0.99 | 0.99 | 0.90 | 0.64 | 0.00 | 0.81 | 1.00 | 0.96 | 0.99 |
natural killer cell | 96 | 0.78 | 0.76 | 0.70 | 0.60 | 0.00 | 0.71 | 0.71 | 0.72 | 0.79 |
precursor B cell | 86 | 0.84 | 0.87 | 0.68 | 0.73 | 0.00 | 0.84 | 0.89 | 0.88 | 0.90 |
luminal epithelial cell of mammary gland | 80 | 0.92 | 0.95 | 0.94 | 0.91 | 0.00 | 0.90 | 0.97 | 0.96 | 0.96 |
endothelial cell of hepatic sinusoid | 59 | 0.93 | 0.97 | 0.90 | 0.81 | 0.00 | 0.88 | 0.93 | 0.93 | 0.94 |
astrocyte | 53 | 0.85 | 0.94 | 0.88 | 0.92 | 0.00 | 0.95 | 0.94 | 0.93 | 0.95 |
immature B cell | 48 | 0.63 | 0.52 | 0.39 | 0.27 | 0.00 | 0.46 | 0.60 | 0.56 | 0.71 |
pancreatic acinar cell | 58 | 0.97 | 0.97 | 0.97 | 0.95 | 0.00 | 0.98 | 1.00 | 1.00 | 1.00 |
secretory cell | 61 | 0.68 | 0.56 | 0.42 | 0.45 | 0.00 | 0.67 | 0.86 | 0.84 | 0.80 |
pancreatic A cell | 67 | 0.88 | 0.92 | 0.86 | 0.90 | 0.00 | 0.94 | 0.96 | 0.95 | 0.94 |
epidermal cell | 59 | 0.82 | 0.79 | 0.39 | 0.69 | 0.00 | 0.69 | 0.84 | 0.76 | 0.83 |
neuron | 37 | 0.65 | 0.68 | 0.60 | 0.68 | 0.00 | 0.85 | 0.92 | 0.82 | 0.86 |
brain pericyte | 40 | 0.79 | 0.83 | 0.73 | 0.74 | 0.00 | 0.91 | 0.95 | 0.88 | 0.86 |
granulocytopoietic cell | 46 | 0.75 | 0.86 | 0.76 | 0.85 | 0.00 | 0.78 | 0.86 | 0.80 | 0.83 |
fibroblast of lung | 48 | 0.95 | 0.95 | 0.93 | 0.92 | 0.00 | 0.93 | 0.97 | 0.95 | 0.97 |
kidney collecting duct epithelial cell | 33 | 0.61 | 0.86 | 0.85 | 0.79 | 0.00 | 0.98 | 0.99 | 0.99 | 0.98 |
aortic endothelial cell | 9 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.14 | 0.11 | 0.08 | 0.09 |
epithelial cell | 34 | 0.31 | 0.11 | 0.43 | 0.41 | 0.00 | 0.37 | 0.54 | 0.48 | 0.59 |
late pro-B cell | 38 | 0.88 | 0.94 | 0.93 | 0.84 | 0.00 | 0.91 | 0.96 | 0.92 | 0.97 |
basal epithelial cell of tracheobronchial tree | 34 | 0.62 | 0.51 | 0.42 | 0.61 | 0.00 | 0.67 | 0.89 | 0.80 | 0.88 |
regular atrial cardiac myocyte | 39 | 0.45 | 0.64 | 0.73 | 0.61 | 0.00 | 0.58 | 0.76 | 0.77 | 0.80 |
epithelial cell of proximal tubule | 33 | 0.35 | 0.78 | 0.69 | 0.71 | 0.00 | 0.91 | 0.96 | 0.97 | 0.93 |
endocardial cell | 38 | 0.96 | 0.95 | 0.93 | 0.80 | 0.00 | 0.82 | 0.97 | 0.96 | 0.99 |
myeloid dendritic cell | 39 | 0.48 | 0.57 | 0.12 | 0.33 | 0.00 | 0.44 | 0.75 | 0.70 | 0.68 |
stromal cell | 25 | 0.26 | 0.35 | 0.20 | 0.29 | 0.00 | 0.36 | 0.58 | 0.58 | 0.62 |
mature alpha-beta T cell | 32 | 0.22 | 0.15 | 0.09 | 0.31 | 0.00 | 0.36 | 0.36 | 0.49 | 0.26 |
cardiac valve cell | 33 | 0.78 | 0.85 | 0.78 | 0.81 | 0.00 | 0.88 | 0.90 | 0.86 | 0.85 |
pancreatic ductal cell | 34 | 1.00 | 0.99 | 0.99 | 0.96 | 0.00 | 0.99 | 1.00 | 1.00 | 1.00 |
oligodendrocyte precursor cell | 36 | 0.97 | 0.99 | 0.93 | 0.93 | 0.00 | 1.00 | 0.99 | 0.94 | 0.99 |
adventitial cell | 41 | 0.48 | 0.40 | 0.31 | 0.10 | 0.00 | 0.27 | 0.79 | 0.55 | 0.69 |
chondrocyte | 23 | 0.73 | 0.79 | 0.81 | 0.67 | 0.00 | 0.81 | 0.89 | 0.85 | 0.83 |
Kupffer cell | 38 | 0.99 | 0.93 | 0.84 | 0.85 | 0.00 | 0.80 | 0.97 | 0.92 | 0.97 |
granulocyte monocyte progenitor cell | 21 | 0.65 | 0.78 | 0.81 | 0.68 | 0.00 | 0.79 | 0.84 | 0.86 | 0.88 |
interneuron | 25 | 0.49 | 0.67 | 0.47 | 0.60 | 0.00 | 0.89 | 0.96 | 0.89 | 0.88 |
myeloid leukocyte | 17 | 0.00 | 0.21 | 0.38 | 0.29 | 0.00 | 0.06 | 0.20 | 0.50 | 0.20 |
classical monocyte | 13 | 0.00 | 0.27 | 0.28 | 0.22 | 0.00 | 0.36 | 0.62 | 0.57 | 0.53 |
mature NK T cell | 19 | 0.40 | 0.17 | 0.26 | 0.16 | 0.00 | 0.46 | 0.33 | 0.68 | 0.58 |
pancreatic D cell | 17 | 0.94 | 0.90 | 0.82 | 0.94 | 0.00 | 0.92 | 1.00 | 1.00 | 1.00 |
brush cell of epithelium proper of large intestine | 15 | 0.76 | 0.73 | 0.33 | 0.74 | 0.00 | 0.64 | 0.94 | 0.88 | 0.90 |
epithelial cell of thymus | 19 | 0.10 | 0.00 | 0.18 | 0.55 | 0.00 | 0.46 | 0.56 | 0.49 | 0.53 |
enteroendocrine cell | 11 | 0.95 | 0.62 | 0.53 | 0.86 | 0.00 | 0.81 | 0.90 | 1.00 | 0.95 |
leukocyte | 16 | 0.00 | 0.61 | 0.40 | 0.00 | 0.00 | 0.06 | 0.75 | 0.81 | 0.67 |
neutrophil | 12 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.18 | 0.42 | 0.40 | 0.11 |
vein endothelial cell | 13 | 0.43 | 0.27 | 0.20 | 0.12 | 0.00 | 0.78 | 1.00 | 0.74 | 0.70 |
kidney collecting duct principal cell | 11 | 0.00 | 0.86 | 0.73 | 0.78 | 0.00 | 0.87 | 0.91 | 0.83 | 0.95 |
neuroepithelial stem cell | 22 | 0.32 | 0.09 | 0.43 | 0.50 | 0.00 | 0.62 | 0.83 | 0.74 | 0.84 |
non-classical monocyte | 16 | 0.00 | 0.55 | 0.33 | 0.22 | 0.00 | 0.46 | 0.67 | 0.72 | 0.59 |
regular ventricular cardiac myocyte | 16 | 0.43 | 0.00 | 0.81 | 0.80 | 0.00 | 0.82 | 1.00 | 0.94 | 0.86 |
kidney loop of Henle ascending limb epithelial cell | 12 | 0.63 | 0.85 | 0.77 | 0.80 | 0.00 | 0.96 | 0.96 | 0.87 | 0.92 |
smooth muscle cell of trachea | 11 | 0.00 | 0.00 | 0.21 | 0.27 | 0.00 | 0.29 | 0.52 | 0.46 | 0.40 |
professional antigen presenting cell | 2 | 0.00 | 0.00 | 0.14 | 0.50 | 0.00 | 0.33 | 0.36 | 0.21 | 0.50 |
smooth muscle cell of the pulmonary artery | 6 | 0.00 | 0.44 | 0.00 | 0.33 | 0.00 | 0.27 | 0.83 | 0.77 | 0.91 |
proerythroblast | 10 | 0.00 | 0.40 | 0.24 | 0.31 | 0.00 | 0.17 | 0.30 | 0.40 | 0.12 |
smooth muscle cell | 14 | 0.00 | 0.58 | 0.33 | 0.24 | 0.00 | 0.67 | 0.93 | 0.84 | 0.77 |
medium spiny neuron | 11 | 1.00 | 0.95 | 0.40 | 0.86 | 0.00 | 0.96 | 1.00 | 1.00 | 1.00 |
endothelial cell of lymphatic vessel | 7 | 0.47 | 0.46 | 0.83 | 0.22 | 0.00 | 0.52 | 0.88 | 0.64 | 0.82 |
neural stem cell | 14 | 0.00 | 0.80 | 0.72 | 0.64 | 0.00 | 0.79 | 0.89 | 0.75 | 0.85 |
mesangial cell | 8 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.21 | 0.43 | 0.56 | 0.55 |
megakaryocyte-erythroid progenitor cell | 10 | 0.32 | 0.40 | 0.40 | 0.57 | 0.00 | 0.55 | 0.57 | 0.67 | 0.64 |
mucus secreting cell | 9 | 0.64 | 0.55 | 0.71 | 0.62 | 0.00 | 0.89 | 0.95 | 1.00 | 0.90 |
early pro-B cell | 7 | 0.00 | 0.83 | 0.83 | 0.86 | 0.00 | 0.86 | 0.86 | 0.80 | 0.92 |
pancreatic PP cell | 8 | 0.00 | 0.40 | 0.22 | 0.20 | 0.00 | 0.71 | 0.88 | 0.80 | 0.40 |
basophil | 11 | 0.27 | 0.43 | 0.84 | 0.64 | 0.00 | 0.69 | 0.95 | 0.82 | 0.87 |
ciliated columnar cell of tracheobronchial tree | 9 | 0.62 | 0.84 | 0.88 | 0.82 | 0.00 | 0.82 | 0.90 | 0.82 | 0.95 |
dendritic cell | 8 | 0.44 | 0.29 | 0.00 | 0.42 | 0.00 | 0.31 | 0.59 | 0.47 | 0.42 |
ependymal cell | 6 | 0.00 | 0.60 | 0.67 | 0.92 | 0.00 | 0.80 | 1.00 | 0.92 | 1.00 |
Bergmann glial cell | 2 | 0.00 | 0.67 | 0.67 | 0.50 | 0.00 | 0.50 | 0.50 | 0.50 | 0.67 |
pulmonary interstitial fibroblast | 4 | 0.38 | 0.50 | 0.50 | 0.75 | 0.00 | 0.67 | 0.86 | 0.67 | 0.67 |
pancreatic stellate cell | 3 | 0.67 | 0.67 | 0.67 | 0.00 | 0.00 | 0.18 | 0.67 | 0.57 | 0.67 |
regulatory T cell | 4 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
pericyte | 4 | 0.00 | 0.67 | 0.75 | 0.67 | 0.00 | 0.67 | 0.75 | 0.89 | 0.75 |
fibrocyte | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
respiratory basal cell | 6 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.56 | 0.80 | 0.91 | 0.67 |
plasma cell | 2 | 0.17 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.36 | 0.36 |
club cell | 2 | 0.00 | 0.00 | 0.10 | 0.20 | 0.00 | 0.11 | 0.67 | 0.29 | 0.40 |
kidney interstitial fibroblast | 1 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 |
lymphoid lineage restricted progenitor cell | 2 | 0.00 | 0.00 | 0.67 | 1.00 | 0.00 | 0.80 | 0.67 | 0.67 | 0.67 |
intermediate monocyte | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
lymphocyte | 1 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
lung macrophage | 1 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
plasmacytoid dendritic cell | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
lung neuroendocrine cell | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
The train accuracies are computed on the training data.
Cell Type | N cells | celltypist | knn bbknn | knn harmony | knn on scvi | onclass | scanvi | svm | xgboost | Consensus Prediction |
---|---|---|---|---|---|---|---|---|---|---|
microglial cell | 11932 | 0.99 | 0.99 | 0.95 | 0.99 | 0.00 | 0.97 | 0.99 | 0.99 | 1.00 |
B cell | 5056 | 0.64 | 0.71 | 0.82 | 0.78 | 0.00 | 0.93 | 0.69 | 0.73 | 0.86 |
endothelial cell | 4433 | 0.79 | 0.79 | 0.85 | 0.78 | 0.00 | 0.81 | 0.87 | 0.84 | 0.92 |
mesenchymal stem cell of adipose tissue | 4275 | 0.85 | 0.88 | 0.81 | 0.76 | 0.00 | 0.97 | 0.94 | 0.88 | 0.96 |
basal cell of epidermis | 3808 | 0.84 | 0.89 | 0.92 | 0.90 | 0.00 | 0.81 | 0.93 | 0.91 | 0.93 |
fibroblast of cardiac tissue | 3575 | 0.92 | 0.91 | 0.81 | 0.78 | 0.00 | 0.96 | 0.95 | 0.92 | 0.96 |
hematopoietic stem cell | 2994 | 0.93 | 0.94 | 0.96 | 0.96 | 0.00 | 0.96 | 0.97 | 0.96 | 0.97 |
granulocyte | 2672 | 0.89 | 0.91 | 0.90 | 0.92 | 0.00 | 0.94 | 0.95 | 0.94 | 0.96 |
naive B cell | 2625 | 0.38 | 0.02 | 0.75 | 0.61 | 0.00 | 0.92 | 0.61 | 0.66 | 0.73 |
skeletal muscle satellite cell | 2441 | 0.97 | 0.97 | 0.91 | 0.98 | 0.00 | 0.97 | 0.98 | 0.97 | 0.98 |
endothelial cell of coronary artery | 2431 | 0.76 | 0.75 | 0.81 | 0.63 | 0.00 | 0.87 | 0.91 | 0.87 | 0.95 |
keratinocyte stem cell | 2384 | 0.94 | 0.94 | 0.96 | 0.95 | 0.00 | 0.95 | 0.97 | 0.95 | 0.97 |
myeloid cell | 2307 | 0.52 | 0.66 | 0.70 | 0.66 | 0.00 | 0.82 | 0.77 | 0.78 | 0.85 |
enterocyte of epithelium of large intestine | 2273 | 0.91 | 0.94 | 0.95 | 0.95 | 0.00 | 0.94 | 0.95 | 0.94 | 0.96 |
macrophage | 2192 | 0.33 | 0.48 | 0.72 | 0.63 | 0.00 | 0.67 | 0.60 | 0.66 | 0.72 |
basal cell | 1933 | 0.99 | 0.98 | 0.98 | 0.96 | 0.00 | 0.97 | 0.99 | 0.99 | 0.99 |
bronchial smooth muscle cell | 1907 | 0.94 | 0.93 | 0.81 | 0.77 | 0.00 | 0.94 | 0.98 | 0.96 | 0.97 |
oligodendrocyte | 1873 | 0.98 | 0.99 | 0.98 | 1.00 | 0.00 | 0.99 | 1.00 | 0.99 | 0.99 |
DN4 thymocyte | 1590 | 0.59 | 0.56 | 0.66 | 0.69 | 0.00 | 0.92 | 0.86 | 0.86 | 0.88 |
epithelial cell of large intestine | 1532 | 0.88 | 0.88 | 0.87 | 0.88 | 0.00 | 0.89 | 0.95 | 0.93 | 0.94 |
thymocyte | 1475 | 0.88 | 0.90 | 0.80 | 0.92 | 0.00 | 0.93 | 0.95 | 0.96 | 0.95 |
large intestine goblet cell | 1419 | 0.78 | 0.83 | 0.89 | 0.88 | 0.00 | 0.92 | 0.96 | 0.93 | 0.95 |
intestinal crypt stem cell | 1424 | 0.87 | 0.90 | 0.91 | 0.91 | 0.00 | 0.90 | 0.95 | 0.91 | 0.95 |
mesenchymal stem cell | 1250 | 0.64 | 0.68 | 0.65 | 0.60 | 0.00 | 0.92 | 0.89 | 0.84 | 0.91 |
bladder urothelial cell | 1278 | 0.98 | 0.94 | 0.95 | 0.94 | 0.00 | 0.98 | 0.99 | 0.99 | 0.99 |
type B pancreatic cell | 1213 | 0.96 | 0.96 | 0.90 | 0.96 | 0.00 | 0.97 | 0.98 | 0.98 | 0.97 |
fibroblast | 1193 | 0.48 | 0.54 | 0.60 | 0.54 | 0.00 | 0.96 | 0.92 | 0.83 | 0.92 |
T cell | 1218 | 0.49 | 0.52 | 0.60 | 0.59 | 0.00 | 0.71 | 0.74 | 0.77 | 0.74 |
monocyte | 1165 | 0.60 | 0.72 | 0.83 | 0.73 | 0.00 | 0.82 | 0.86 | 0.84 | 0.91 |
keratinocyte | 1084 | 0.76 | 0.88 | 0.91 | 0.83 | 0.00 | 0.78 | 0.93 | 0.90 | 0.92 |
CD4-positive, alpha-beta T cell | 1028 | 0.54 | 0.54 | 0.66 | 0.60 | 0.00 | 0.72 | 0.73 | 0.79 | 0.78 |
hepatocyte | 1047 | 0.96 | 0.95 | 0.95 | 0.96 | 0.00 | 0.96 | 0.98 | 0.98 | 0.98 |
CD8-positive, alpha-beta T cell | 959 | 0.49 | 0.51 | 0.62 | 0.59 | 0.00 | 0.74 | 0.75 | 0.78 | 0.76 |
promonocyte | 917 | 0.45 | 0.60 | 0.93 | 0.61 | 0.00 | 0.95 | 0.87 | 0.87 | 0.95 |
bladder cell | 914 | 0.98 | 0.98 | 0.91 | 0.80 | 0.00 | 0.99 | 1.00 | 0.96 | 1.00 |
natural killer cell | 779 | 0.75 | 0.75 | 0.75 | 0.73 | 0.00 | 0.80 | 0.88 | 0.90 | 0.88 |
precursor B cell | 770 | 0.83 | 0.85 | 0.87 | 0.80 | 0.00 | 0.90 | 0.96 | 0.95 | 0.94 |
luminal epithelial cell of mammary gland | 688 | 0.95 | 0.96 | 0.99 | 0.97 | 0.00 | 0.95 | 1.00 | 0.98 | 0.99 |
endothelial cell of hepatic sinusoid | 558 | 0.94 | 0.85 | 0.90 | 0.84 | 0.00 | 0.92 | 0.99 | 0.98 | 0.99 |
astrocyte | 539 | 0.86 | 0.93 | 0.95 | 0.95 | 0.00 | 0.97 | 0.99 | 0.99 | 0.98 |
immature B cell | 541 | 0.64 | 0.55 | 0.63 | 0.54 | 0.00 | 0.80 | 0.79 | 0.79 | 0.87 |
pancreatic acinar cell | 518 | 0.92 | 0.94 | 0.94 | 0.94 | 0.00 | 0.97 | 0.99 | 0.99 | 0.98 |
secretory cell | 502 | 0.64 | 0.28 | 0.78 | 0.71 | 0.00 | 0.86 | 0.95 | 0.91 | 0.93 |
pancreatic A cell | 454 | 0.83 | 0.82 | 0.87 | 0.87 | 0.00 | 0.92 | 0.97 | 0.96 | 0.91 |
epidermal cell | 433 | 0.72 | 0.67 | 0.78 | 0.77 | 0.00 | 0.65 | 0.84 | 0.82 | 0.83 |
neuron | 447 | 0.69 | 0.66 | 0.72 | 0.80 | 0.00 | 0.91 | 0.98 | 0.97 | 0.95 |
brain pericyte | 444 | 0.79 | 0.80 | 0.82 | 0.83 | 0.00 | 0.94 | 1.00 | 0.98 | 0.92 |
granulocytopoietic cell | 437 | 0.78 | 0.87 | 0.90 | 0.89 | 0.00 | 0.81 | 0.93 | 0.92 | 0.94 |
fibroblast of lung | 431 | 0.96 | 0.96 | 0.88 | 0.88 | 0.00 | 0.98 | 0.99 | 0.97 | 0.99 |
kidney collecting duct epithelial cell | 407 | 0.65 | 0.81 | 0.88 | 0.81 | 0.00 | 0.96 | 1.00 | 0.99 | 0.97 |
aortic endothelial cell | 420 | 0.21 | 0.02 | 0.39 | 0.40 | 0.00 | 0.67 | 0.55 | 0.49 | 0.82 |
epithelial cell | 392 | 0.30 | 0.04 | 0.72 | 0.64 | 0.00 | 0.76 | 0.72 | 0.74 | 0.82 |
late pro-B cell | 373 | 0.84 | 0.91 | 0.93 | 0.86 | 0.00 | 0.94 | 0.99 | 0.98 | 0.97 |
basal epithelial cell of tracheobronchial tree | 367 | 0.69 | 0.53 | 0.80 | 0.69 | 0.00 | 0.88 | 0.95 | 0.88 | 0.94 |
regular atrial cardiac myocyte | 360 | 0.54 | 0.60 | 0.81 | 0.72 | 0.00 | 0.74 | 0.81 | 0.88 | 0.91 |
epithelial cell of proximal tubule | 349 | 0.39 | 0.77 | 0.87 | 0.77 | 0.00 | 0.95 | 0.99 | 0.99 | 0.96 |
endocardial cell | 337 | 0.96 | 0.93 | 0.96 | 0.83 | 0.00 | 0.93 | 0.96 | 0.95 | 0.97 |
myeloid dendritic cell | 334 | 0.45 | 0.47 | 0.86 | 0.58 | 0.00 | 0.91 | 0.89 | 0.82 | 0.88 |
stromal cell | 315 | 0.24 | 0.19 | 0.62 | 0.47 | 0.00 | 0.94 | 0.76 | 0.68 | 0.92 |
mature alpha-beta T cell | 298 | 0.32 | 0.19 | 0.60 | 0.48 | 0.00 | 0.80 | 0.74 | 0.86 | 0.83 |
cardiac valve cell | 282 | 0.86 | 0.91 | 0.81 | 0.88 | 0.00 | 0.95 | 0.96 | 0.97 | 0.94 |
pancreatic ductal cell | 279 | 0.98 | 0.97 | 0.99 | 0.94 | 0.00 | 0.98 | 0.99 | 0.99 | 0.99 |
oligodendrocyte precursor cell | 276 | 0.96 | 0.98 | 0.95 | 0.98 | 0.00 | 0.99 | 1.00 | 1.00 | 1.00 |
adventitial cell | 247 | 0.48 | 0.52 | 0.72 | 0.30 | 0.00 | 0.89 | 0.89 | 0.73 | 0.95 |
chondrocyte | 252 | 0.87 | 0.80 | 0.91 | 0.82 | 0.00 | 0.89 | 0.98 | 0.95 | 0.95 |
Kupffer cell | 224 | 0.94 | 0.64 | 0.88 | 0.82 | 0.00 | 0.75 | 0.98 | 0.97 | 0.99 |
granulocyte monocyte progenitor cell | 229 | 0.62 | 0.78 | 0.87 | 0.86 | 0.00 | 0.83 | 0.90 | 0.89 | 0.91 |
interneuron | 215 | 0.55 | 0.68 | 0.82 | 0.76 | 0.00 | 0.89 | 0.98 | 0.94 | 0.90 |
myeloid leukocyte | 192 | 0.00 | 0.11 | 0.82 | 0.40 | 0.00 | 0.87 | 0.91 | 0.89 | 0.97 |
classical monocyte | 189 | 0.00 | 0.34 | 0.64 | 0.53 | 0.00 | 0.90 | 0.87 | 0.86 | 0.92 |
mature NK T cell | 180 | 0.35 | 0.14 | 0.66 | 0.38 | 0.00 | 0.72 | 0.91 | 0.92 | 0.91 |
pancreatic D cell | 174 | 0.90 | 0.89 | 0.87 | 0.89 | 0.00 | 0.91 | 0.99 | 0.98 | 0.96 |
brush cell of epithelium proper of large intestine | 160 | 0.76 | 0.76 | 0.77 | 0.81 | 0.00 | 0.85 | 0.98 | 0.97 | 0.94 |
epithelial cell of thymus | 146 | 0.22 | 0.01 | 0.58 | 0.50 | 0.00 | 0.76 | 0.89 | 0.78 | 0.93 |
enteroendocrine cell | 150 | 0.88 | 0.53 | 0.76 | 0.89 | 0.00 | 0.91 | 0.99 | 0.98 | 0.98 |
leukocyte | 142 | 0.00 | 0.31 | 0.71 | 0.44 | 0.00 | 0.74 | 0.81 | 0.85 | 0.95 |
neutrophil | 141 | 0.00 | 0.10 | 0.28 | 0.21 | 0.00 | 0.80 | 0.75 | 0.69 | 0.80 |
vein endothelial cell | 139 | 0.53 | 0.54 | 0.71 | 0.30 | 0.00 | 0.88 | 0.95 | 0.89 | 0.85 |
kidney collecting duct principal cell | 140 | 0.00 | 0.78 | 0.88 | 0.75 | 0.00 | 0.96 | 0.99 | 0.96 | 0.98 |
neuroepithelial stem cell | 129 | 0.21 | 0.03 | 0.84 | 0.73 | 0.00 | 0.73 | 0.91 | 0.83 | 0.93 |
non-classical monocyte | 133 | 0.00 | 0.36 | 0.59 | 0.38 | 0.00 | 0.83 | 0.81 | 0.77 | 0.89 |
regular ventricular cardiac myocyte | 129 | 0.53 | 0.00 | 0.87 | 0.84 | 0.00 | 0.91 | 0.98 | 0.98 | 0.98 |
kidney loop of Henle ascending limb epithelial cell | 132 | 0.65 | 0.85 | 0.92 | 0.69 | 0.00 | 0.96 | 1.00 | 0.99 | 0.99 |
smooth muscle cell of trachea | 114 | 0.00 | 0.11 | 0.58 | 0.52 | 0.00 | 0.85 | 0.85 | 0.77 | 0.84 |
professional antigen presenting cell | 114 | 0.14 | 0.15 | 0.53 | 0.61 | 0.00 | 0.84 | 0.87 | 0.80 | 0.93 |
smooth muscle cell of the pulmonary artery | 105 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.53 | 0.89 | 0.83 | 0.91 |
proerythroblast | 97 | 0.00 | 0.10 | 0.62 | 0.28 | 0.00 | 0.76 | 0.92 | 0.87 | 0.89 |
smooth muscle cell | 89 | 0.00 | 0.34 | 0.67 | 0.42 | 0.00 | 0.95 | 0.97 | 0.92 | 0.91 |
medium spiny neuron | 92 | 0.98 | 0.54 | 0.83 | 0.88 | 0.00 | 0.94 | 1.00 | 0.99 | 0.99 |
endothelial cell of lymphatic vessel | 92 | 0.47 | 0.41 | 0.93 | 0.55 | 0.00 | 0.63 | 0.81 | 0.72 | 0.85 |
neural stem cell | 83 | 0.00 | 0.75 | 0.83 | 0.94 | 0.00 | 0.93 | 1.00 | 0.95 | 0.99 |
mesangial cell | 84 | 0.00 | 0.16 | 0.61 | 0.39 | 0.00 | 0.79 | 0.86 | 0.68 | 0.91 |
megakaryocyte-erythroid progenitor cell | 70 | 0.30 | 0.27 | 0.80 | 0.82 | 0.00 | 0.81 | 0.89 | 0.96 | 0.94 |
mucus secreting cell | 64 | 0.57 | 0.64 | 0.86 | 0.82 | 0.00 | 0.96 | 0.95 | 0.98 | 0.98 |
early pro-B cell | 65 | 0.00 | 0.69 | 0.70 | 0.79 | 0.00 | 0.92 | 0.99 | 0.99 | 0.94 |
pancreatic PP cell | 63 | 0.00 | 0.17 | 0.67 | 0.35 | 0.00 | 0.90 | 0.99 | 0.98 | 0.82 |
basophil | 60 | 0.28 | 0.61 | 0.76 | 0.81 | 0.00 | 0.75 | 0.97 | 0.82 | 0.85 |
ciliated columnar cell of tracheobronchial tree | 61 | 0.80 | 0.87 | 0.96 | 0.86 | 0.00 | 0.88 | 0.99 | 0.93 | 0.98 |
dendritic cell | 54 | 0.45 | 0.26 | 0.77 | 0.64 | 0.00 | 0.91 | 0.91 | 0.84 | 0.81 |
ependymal cell | 49 | 0.00 | 0.70 | 0.97 | 0.85 | 0.00 | 0.95 | 1.00 | 1.00 | 0.98 |
Bergmann glial cell | 52 | 0.00 | 0.45 | 0.86 | 0.76 | 0.00 | 0.77 | 1.00 | 1.00 | 0.96 |
pulmonary interstitial fibroblast | 45 | 0.41 | 0.59 | 0.76 | 0.74 | 0.00 | 0.92 | 1.00 | 0.94 | 0.95 |
pancreatic stellate cell | 45 | 0.88 | 0.47 | 0.93 | 0.48 | 0.00 | 0.86 | 0.90 | 0.89 | 0.95 |
regulatory T cell | 43 | 0.00 | 0.00 | 0.12 | 0.04 | 0.00 | 0.68 | 0.90 | 0.91 | 0.44 |
pericyte | 34 | 0.00 | 0.77 | 0.72 | 0.82 | 0.00 | 0.84 | 0.96 | 0.94 | 0.93 |
fibrocyte | 35 | 0.00 | 0.00 | 0.40 | 0.41 | 0.00 | 0.60 | 0.76 | 0.82 | 0.87 |
respiratory basal cell | 28 | 0.00 | 0.00 | 0.89 | 0.74 | 0.00 | 0.68 | 0.95 | 0.98 | 0.96 |
plasma cell | 23 | 0.16 | 0.00 | 0.75 | 0.16 | 0.00 | 0.25 | 0.45 | 0.36 | 0.43 |
club cell | 20 | 0.00 | 0.00 | 0.22 | 0.17 | 0.00 | 0.26 | 0.91 | 0.44 | 0.57 |
kidney interstitial fibroblast | 15 | 0.00 | 0.00 | 0.64 | 0.85 | 0.00 | 0.83 | 0.86 | 0.97 | 1.00 |
lymphoid lineage restricted progenitor cell | 11 | 0.00 | 0.00 | 0.90 | 0.91 | 0.00 | 0.69 | 0.63 | 1.00 | 0.95 |
intermediate monocyte | 12 | 0.00 | 0.00 | 0.25 | 0.13 | 0.00 | 0.91 | 1.00 | 1.00 | 0.50 |
lymphocyte | 9 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.76 | 1.00 | 1.00 | 0.20 |
lung macrophage | 8 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 | 0.44 | 0.89 | 0.80 | 0.93 |
plasmacytoid dendritic cell | 6 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.63 | 0.43 | 0.86 | 0.67 |
lung neuroendocrine cell | 4 | 0.00 | 0.00 | 0.86 | 0.86 | 0.00 | 1.00 | 0.89 | 1.00 | 0.86 |
References
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