Popular Vote (popV) model for automated cell type annotation of single-cell RNA-seq data. We provide here pretrained models for plug-in use in your own analysis. Follow our tutorial to learn how to use the model for cell type annotation.
Model description
Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. Despite rapid advances over recent years, many of the molecular and cellular processes that underlie the progressive loss of healthy physiology are poorly understood. To gain a better insight into these processes, here we generate a single-cell transcriptomic atlas across the lifespan of Mus musculus that includes data from 23 tissues and organs. We found cell-specific changes occurring across multiple cell types and organs, as well as age-related changes in the cellular composition of different organs. Using single-cell transcriptomic data, we assessed cell-type-specific manifestations of different hallmarks of ageing—such as senescence, genomic instability and changes in the immune system. This transcriptomic atlas—which we denote Tabula Muris Senis, or ‘Mouse Ageing Cell Atlas’—provides molecular information about how the most important hallmarks of ageing are reflected in a broad range of tissues and cell types.
Link to CELLxGENE: Link to the data in the CELLxGENE browser for interactive exploration of the data and download of the source data.
Training Code URL: Not provided by uploader.
Metrics
We provide here accuracies for each of the experts and the ensemble model. The validation set accuracies are computed on a 10% random subset of the data that was not used for training.
Cell Type | N cells | celltypist | knn bbknn | knn harmony | knn on scvi | onclass | scanvi | svm | xgboost | Consensus Prediction |
---|---|---|---|---|---|---|---|---|---|---|
B cell | 3058 | 0.94 | 0.92 | 0.89 | 0.92 | 0.00 | 0.89 | 0.86 | 0.88 | 0.94 |
mesenchymal stem cell | 1519 | 0.91 | 0.82 | 0.94 | 0.87 | 0.00 | 0.75 | 0.94 | 0.90 | 0.96 |
granulocyte | 1251 | 0.89 | 0.89 | 0.83 | 0.83 | 0.00 | 0.88 | 0.80 | 0.86 | 0.91 |
basal cell of epidermis | 1143 | 0.89 | 0.91 | 0.89 | 0.93 | 0.00 | 0.81 | 0.90 | 0.84 | 0.95 |
T cell | 1143 | 0.85 | 0.81 | 0.77 | 0.73 | 0.00 | 0.76 | 0.72 | 0.78 | 0.86 |
keratinocyte | 1118 | 0.90 | 0.85 | 0.91 | 0.91 | 0.00 | 0.81 | 0.91 | 0.87 | 0.96 |
endothelial cell | 1041 | 0.89 | 0.89 | 0.84 | 0.88 | 0.00 | 0.83 | 0.96 | 0.90 | 0.95 |
classical monocyte | 799 | 0.83 | 0.54 | 0.77 | 0.70 | 0.00 | 0.64 | 0.85 | 0.86 | 0.93 |
granulocytopoietic cell | 771 | 0.78 | 0.80 | 0.81 | 0.80 | 0.00 | 0.82 | 0.77 | 0.81 | 0.86 |
macrophage | 728 | 0.69 | 0.64 | 0.68 | 0.69 | 0.00 | 0.55 | 0.69 | 0.73 | 0.81 |
bladder urothelial cell | 546 | 0.99 | 1.00 | 0.93 | 0.95 | 0.00 | 0.96 | 1.00 | 0.99 | 1.00 |
proerythroblast | 450 | 0.64 | 0.69 | 0.64 | 0.55 | 0.00 | 0.71 | 0.61 | 0.68 | 0.76 |
kidney proximal convoluted tubule epithelial cell | 431 | 0.84 | 0.86 | 0.80 | 0.84 | 0.00 | 0.84 | 0.89 | 0.87 | 0.87 |
endothelial cell of coronary artery | 329 | 0.77 | 0.84 | 0.70 | 0.80 | 0.00 | 0.69 | 0.96 | 0.88 | 0.93 |
epithelial cell of proximal tubule | 307 | 0.78 | 0.84 | 0.70 | 0.75 | 0.00 | 0.81 | 0.89 | 0.84 | 0.84 |
bladder cell | 299 | 0.98 | 0.97 | 0.89 | 0.80 | 0.00 | 0.68 | 0.99 | 0.97 | 0.99 |
mature NK T cell | 276 | 0.65 | 0.70 | 0.54 | 0.40 | 0.00 | 0.61 | 0.59 | 0.71 | 0.74 |
hepatocyte | 300 | 1.00 | 1.00 | 1.00 | 0.98 | 0.00 | 0.99 | 1.00 | 0.99 | 1.00 |
erythroblast | 272 | 0.67 | 0.69 | 0.71 | 0.67 | 0.00 | 0.74 | 0.70 | 0.74 | 0.77 |
promonocyte | 285 | 0.81 | 0.78 | 0.83 | 0.78 | 0.00 | 0.78 | 0.88 | 0.89 | 0.92 |
stromal cell | 272 | 0.70 | 0.28 | 0.89 | 0.65 | 0.00 | 0.63 | 0.94 | 0.77 | 0.89 |
megakaryocyte-erythroid progenitor cell | 268 | 0.63 | 0.67 | 0.53 | 0.70 | 0.00 | 0.67 | 0.68 | 0.65 | 0.72 |
type B pancreatic cell | 269 | 0.91 | 0.88 | 0.76 | 0.98 | 0.00 | 0.97 | 0.99 | 0.99 | 0.99 |
Kupffer cell | 263 | 0.97 | 0.51 | 0.76 | 0.77 | 0.00 | 0.84 | 0.98 | 0.96 | 0.97 |
natural killer cell | 267 | 0.89 | 0.88 | 0.78 | 0.81 | 0.00 | 0.82 | 0.88 | 0.88 | 0.91 |
professional antigen presenting cell | 274 | 0.00 | 0.01 | 0.15 | 0.07 | 0.00 | 0.01 | 0.54 | 0.49 | 0.06 |
fibroblast of cardiac tissue | 246 | 0.97 | 0.97 | 0.90 | 0.68 | 0.00 | 0.66 | 0.98 | 0.95 | 0.98 |
monocyte | 246 | 0.77 | 0.50 | 0.78 | 0.38 | 0.00 | 0.59 | 0.92 | 0.85 | 0.90 |
bronchial smooth muscle cell | 221 | 0.96 | 0.96 | 0.86 | 0.93 | 0.00 | 0.97 | 0.97 | 0.95 | 0.97 |
hematopoietic precursor cell | 210 | 0.59 | 0.70 | 0.50 | 0.53 | 0.00 | 0.66 | 0.71 | 0.79 | 0.78 |
pancreatic acinar cell | 228 | 0.99 | 0.97 | 0.55 | 0.99 | 0.00 | 0.99 | 1.00 | 1.00 | 1.00 |
skeletal muscle satellite cell | 183 | 0.99 | 0.99 | 0.95 | 0.97 | 0.00 | 0.96 | 0.99 | 0.98 | 0.99 |
DN4 thymocyte | 195 | 0.23 | 0.04 | 0.45 | 0.23 | 0.00 | 0.00 | 0.59 | 0.61 | 0.33 |
luminal epithelial cell of mammary gland | 180 | 0.93 | 0.91 | 0.93 | 0.91 | 0.00 | 0.91 | 0.99 | 0.95 | 0.96 |
mesenchymal stem cell of adipose tissue | 188 | 0.64 | 0.49 | 0.68 | 0.58 | 0.00 | 0.15 | 0.93 | 0.74 | 0.89 |
thymocyte | 175 | 0.97 | 0.50 | 0.89 | 0.95 | 0.00 | 0.94 | 0.98 | 0.93 | 0.98 |
myeloid cell | 234 | 0.56 | 0.07 | 0.51 | 0.47 | 0.00 | 0.03 | 0.86 | 0.80 | 0.71 |
fibroblast | 179 | 0.61 | 0.11 | 0.67 | 0.64 | 0.00 | 0.56 | 0.69 | 0.70 | 0.79 |
immature T cell | 172 | 0.90 | 0.74 | 0.86 | 0.94 | 0.00 | 0.96 | 0.94 | 0.88 | 0.95 |
intermediate monocyte | 176 | 0.66 | 0.27 | 0.62 | 0.61 | 0.00 | 0.65 | 0.60 | 0.64 | 0.77 |
epidermal cell | 175 | 0.94 | 0.00 | 0.88 | 0.93 | 0.00 | 0.89 | 0.93 | 0.89 | 0.96 |
chondrocyte | 160 | 0.87 | 0.00 | 0.86 | 0.84 | 0.00 | 0.88 | 0.88 | 0.89 | 0.89 |
plasma cell | 153 | 0.65 | 0.66 | 0.66 | 0.69 | 0.00 | 0.54 | 0.57 | 0.66 | 0.76 |
smooth muscle cell | 171 | 0.74 | 0.81 | 0.79 | 0.81 | 0.00 | 0.80 | 0.87 | 0.82 | 0.83 |
lymphocyte | 147 | 0.24 | 0.24 | 0.30 | 0.20 | 0.00 | 0.03 | 0.30 | 0.44 | 0.38 |
basal cell | 156 | 0.98 | 0.98 | 0.96 | 0.95 | 0.00 | 0.96 | 0.99 | 0.97 | 0.99 |
naive T cell | 151 | 0.80 | 0.90 | 0.89 | 0.90 | 0.00 | 0.89 | 0.89 | 0.88 | 0.90 |
kidney loop of Henle thick ascending limb epithelial cell | 152 | 0.92 | 0.92 | 0.89 | 0.92 | 0.00 | 0.83 | 0.90 | 0.90 | 0.93 |
fibroblast of lung | 146 | 0.95 | 0.92 | 0.96 | 0.94 | 0.00 | 0.96 | 0.99 | 0.97 | 0.97 |
leukocyte | 142 | 0.66 | 0.65 | 0.53 | 0.42 | 0.00 | 0.45 | 0.78 | 0.78 | 0.82 |
alveolar macrophage | 131 | 0.98 | 0.98 | 0.99 | 0.95 | 0.00 | 0.97 | 0.99 | 0.98 | 0.99 |
lung macrophage | 127 | 0.89 | 0.05 | 0.61 | 0.50 | 0.00 | 0.84 | 0.86 | 0.88 | 0.94 |
enterocyte of epithelium of large intestine | 98 | 0.96 | 0.69 | 0.87 | 0.92 | 0.00 | 0.94 | 0.98 | 0.94 | 0.97 |
non-classical monocyte | 93 | 0.76 | 0.78 | 0.76 | 0.75 | 0.00 | 0.72 | 0.85 | 0.77 | 0.80 |
double negative thymocyte | 80 | 0.74 | 0.00 | 0.40 | 0.65 | 0.00 | 0.77 | 0.84 | 0.78 | 0.88 |
precursor B cell | 108 | 0.78 | 0.87 | 0.75 | 0.81 | 0.00 | 0.88 | 0.95 | 0.93 | 0.90 |
mesenchymal cell | 98 | 0.28 | 0.00 | 0.11 | 0.07 | 0.00 | 0.15 | 0.45 | 0.55 | 0.38 |
CD8-positive, alpha-beta T cell | 78 | 0.53 | 0.68 | 0.26 | 0.20 | 0.00 | 0.50 | 0.65 | 0.71 | 0.70 |
immature B cell | 85 | 0.96 | 0.91 | 0.93 | 0.92 | 0.00 | 0.89 | 0.66 | 0.86 | 0.96 |
kidney collecting duct principal cell | 68 | 0.64 | 0.99 | 0.93 | 0.93 | 0.00 | 0.86 | 0.94 | 0.95 | 0.98 |
kidney distal convoluted tubule epithelial cell | 69 | 0.00 | 0.97 | 0.88 | 0.91 | 0.00 | 0.89 | 0.91 | 0.88 | 0.93 |
endocardial cell | 62 | 0.92 | 0.96 | 0.88 | 0.94 | 0.00 | 0.88 | 0.95 | 0.82 | 0.96 |
endothelial cell of hepatic sinusoid | 52 | 0.97 | 0.93 | 0.78 | 0.83 | 0.00 | 0.72 | 0.98 | 0.91 | 0.93 |
neutrophil | 62 | 0.63 | 0.62 | 0.68 | 0.71 | 0.00 | 0.85 | 0.91 | 0.79 | 0.84 |
CD4-positive, alpha-beta T cell | 49 | 0.00 | 0.30 | 0.17 | 0.19 | 0.00 | 0.23 | 0.39 | 0.37 | 0.43 |
late pro-B cell | 59 | 0.78 | 0.80 | 0.45 | 0.69 | 0.00 | 0.85 | 0.78 | 0.79 | 0.88 |
adventitial cell | 47 | 0.71 | 0.47 | 0.79 | 0.41 | 0.00 | 0.37 | 0.87 | 0.68 | 0.85 |
basal epithelial cell of tracheobronchial tree | 48 | 0.97 | 0.06 | 0.91 | 0.83 | 0.00 | 0.68 | 0.98 | 0.93 | 0.99 |
plasmatocyte | 39 | 0.77 | 0.78 | 0.67 | 0.87 | 0.00 | 0.53 | 0.85 | 0.81 | 0.92 |
keratinocyte stem cell | 42 | 0.84 | 0.00 | 0.72 | 0.89 | 0.00 | 0.86 | 0.91 | 0.77 | 0.91 |
brush cell | 35 | 0.86 | 0.83 | 0.67 | 0.83 | 0.00 | 0.86 | 0.84 | 0.76 | 0.88 |
erythroid progenitor cell, mammalian | 37 | 0.78 | 0.00 | 0.48 | 0.39 | 0.00 | 0.23 | 0.71 | 0.60 | 0.89 |
naive B cell | 38 | 0.95 | 0.96 | 0.88 | 0.92 | 0.00 | 0.82 | 0.87 | 0.91 | 0.94 |
kidney cortex artery cell | 37 | 0.76 | 0.85 | 0.33 | 0.67 | 0.00 | 0.54 | 0.76 | 0.67 | 0.84 |
erythrocyte | 30 | 0.63 | 0.49 | 0.71 | 0.62 | 0.00 | 0.38 | 0.83 | 0.71 | 0.81 |
intestinal crypt stem cell | 29 | 0.57 | 0.00 | 0.17 | 0.77 | 0.00 | 0.51 | 0.89 | 0.83 | 0.86 |
epithelial cell | 30 | 0.65 | 0.04 | 0.75 | 0.66 | 0.00 | 0.67 | 0.92 | 0.78 | 0.80 |
pancreatic ductal cell | 28 | 0.78 | 0.56 | 0.80 | 0.85 | 0.00 | 0.83 | 0.86 | 0.86 | 0.84 |
cardiac muscle cell | 32 | 0.98 | 0.97 | 1.00 | 1.00 | 0.00 | 0.93 | 0.98 | 0.97 | 0.98 |
vein endothelial cell | 32 | 0.54 | 0.76 | 0.50 | 0.71 | 0.00 | 0.67 | 0.87 | 0.79 | 0.81 |
pancreatic A cell | 37 | 0.00 | 0.00 | 0.24 | 0.93 | 0.00 | 0.84 | 0.92 | 0.93 | 0.92 |
myeloid leukocyte | 28 | 0.51 | 0.07 | 0.49 | 0.06 | 0.00 | 0.06 | 0.60 | 0.81 | 0.87 |
Schwann cell | 22 | 0.75 | 0.23 | 0.84 | 0.83 | 0.00 | 0.90 | 0.81 | 0.75 | 0.79 |
pancreatic D cell | 21 | 0.33 | 0.37 | 0.36 | 0.91 | 0.00 | 0.86 | 0.91 | 0.98 | 0.93 |
mesangial cell | 28 | 0.00 | 0.80 | 0.51 | 0.67 | 0.00 | 0.70 | 0.92 | 0.87 | 0.91 |
basophil | 28 | 0.67 | 0.77 | 0.85 | 0.65 | 0.00 | 0.55 | 0.66 | 0.74 | 0.85 |
myeloid dendritic cell | 37 | 0.35 | 0.68 | 0.29 | 0.48 | 0.00 | 0.46 | 0.81 | 0.73 | 0.83 |
epithelial cell of large intestine | 25 | 0.00 | 0.08 | 0.28 | 0.73 | 0.00 | 0.75 | 0.83 | 0.81 | 0.88 |
pulmonary interstitial fibroblast | 25 | 0.88 | 0.85 | 0.94 | 1.00 | 0.00 | 0.94 | 0.94 | 0.91 | 0.98 |
kidney loop of Henle ascending limb epithelial cell | 21 | 0.00 | 0.27 | 0.21 | 0.23 | 0.00 | 0.41 | 0.45 | 0.54 | 0.30 |
cell of skeletal muscle | 13 | 1.00 | 0.96 | 0.96 | 0.96 | 0.00 | 0.58 | 0.96 | 0.92 | 1.00 |
Langerhans cell | 13 | 0.96 | 0.76 | 0.00 | 0.58 | 0.00 | 0.39 | 0.87 | 0.83 | 0.92 |
stem cell of epidermis | 9 | 0.49 | 0.00 | 0.80 | 0.86 | 0.00 | 0.13 | 0.82 | 0.56 | 0.86 |
kidney capillary endothelial cell | 19 | 0.29 | 0.54 | 0.32 | 0.41 | 0.00 | 0.28 | 0.38 | 0.35 | 0.34 |
large intestine goblet cell | 18 | 0.00 | 0.00 | 0.62 | 0.91 | 0.00 | 0.89 | 1.00 | 0.94 | 0.97 |
pancreatic PP cell | 14 | 0.00 | 0.00 | 0.00 | 0.88 | 0.00 | 0.76 | 0.86 | 0.92 | 0.93 |
macrophage dendritic cell progenitor | 25 | 0.00 | 0.52 | 0.16 | 0.38 | 0.00 | 0.70 | 0.69 | 0.49 | 0.70 |
DN3 thymocyte | 15 | 0.93 | 0.85 | 0.00 | 0.93 | 0.00 | 0.85 | 0.86 | 0.85 | 0.93 |
smooth muscle cell of trachea | 11 | 0.00 | 0.00 | 0.38 | 0.38 | 0.00 | 0.12 | 0.62 | 0.64 | 0.31 |
regulatory T cell | 11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.23 | 0.20 | 0.21 | 0.00 |
plasmacytoid dendritic cell | 16 | 0.48 | 0.40 | 0.17 | 0.32 | 0.00 | 0.59 | 0.65 | 0.32 | 0.64 |
smooth muscle cell of the pulmonary artery | 6 | 0.00 | 0.80 | 0.67 | 0.46 | 0.00 | 0.45 | 0.86 | 0.62 | 0.80 |
kidney proximal straight tubule epithelial cell | 7 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.21 | 0.00 |
blood cell | 11 | 0.00 | 0.00 | 0.00 | 0.14 | 0.00 | 0.00 | 0.27 | 0.31 | 0.00 |
immature NK T cell | 6 | 0.29 | 0.22 | 0.33 | 0.25 | 0.00 | 0.10 | 0.32 | 0.57 | 0.40 |
cardiac neuron | 7 | 0.00 | 0.22 | 0.40 | 0.24 | 0.00 | 0.24 | 0.48 | 0.59 | 0.44 |
mast cell | 4 | 0.00 | 0.00 | 0.16 | 0.00 | 0.00 | 0.17 | 0.60 | 0.43 | 0.31 |
pericyte | 8 | 1.00 | 0.94 | 0.93 | 0.94 | 0.00 | 0.94 | 0.70 | 1.00 | 1.00 |
ciliated columnar cell of tracheobronchial tree | 3 | 0.00 | 0.04 | 0.75 | 0.86 | 0.00 | 0.55 | 0.14 | 1.00 | 1.00 |
neuroendocrine cell | 7 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.17 | 0.00 |
dendritic cell | 8 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.19 | 0.67 | 0.47 | 0.55 |
endothelial cell of lymphatic vessel | 3 | 0.00 | 0.50 | 0.80 | 0.00 | 0.00 | 0.14 | 0.67 | 0.36 | 0.80 |
hepatic stellate cell | 3 | 0.00 | 0.00 | 0.80 | 0.67 | 0.00 | 0.22 | 1.00 | 0.80 | 0.80 |
hematopoietic stem cell | 5 | 0.00 | 0.00 | 0.00 | 0.33 | 0.00 | 0.38 | 0.55 | 0.67 | 0.57 |
kidney collecting duct epithelial cell | 2 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
pancreatic stellate cell | 1 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 1.00 | 0.00 | 0.00 |
club cell | 1 | 0.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.15 | 0.17 |
lung neuroendocrine cell | 1 | 0.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.00 | 0.15 | 1.00 | 1.00 |
kidney cell | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
duct epithelial cell | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
The train accuracies are computed on the training data.
Cell Type | N cells | celltypist | knn bbknn | knn harmony | knn on scvi | onclass | scanvi | svm | xgboost | Consensus Prediction |
---|---|---|---|---|---|---|---|---|---|---|
B cell | 27660 | 0.94 | 0.91 | 0.94 | 0.95 | 0.00 | 0.95 | 0.88 | 0.89 | 0.96 |
mesenchymal stem cell | 13194 | 0.90 | 0.80 | 0.97 | 0.91 | 0.00 | 0.85 | 0.94 | 0.91 | 0.96 |
granulocyte | 11345 | 0.88 | 0.88 | 0.94 | 0.93 | 0.00 | 0.91 | 0.81 | 0.86 | 0.92 |
basal cell of epidermis | 10288 | 0.89 | 0.88 | 0.94 | 0.95 | 0.00 | 0.87 | 0.89 | 0.85 | 0.95 |
T cell | 10273 | 0.83 | 0.77 | 0.82 | 0.87 | 0.00 | 0.89 | 0.75 | 0.78 | 0.92 |
keratinocyte | 10024 | 0.89 | 0.83 | 0.95 | 0.95 | 0.00 | 0.87 | 0.91 | 0.88 | 0.96 |
endothelial cell | 8853 | 0.89 | 0.86 | 0.89 | 0.93 | 0.00 | 0.92 | 0.96 | 0.91 | 0.97 |
classical monocyte | 7123 | 0.85 | 0.48 | 0.86 | 0.90 | 0.00 | 0.90 | 0.86 | 0.86 | 0.94 |
granulocytopoietic cell | 6828 | 0.80 | 0.75 | 0.93 | 0.91 | 0.00 | 0.85 | 0.80 | 0.83 | 0.90 |
macrophage | 6456 | 0.69 | 0.62 | 0.84 | 0.82 | 0.00 | 0.84 | 0.72 | 0.75 | 0.87 |
bladder urothelial cell | 4685 | 0.99 | 0.99 | 1.00 | 0.98 | 0.00 | 0.99 | 1.00 | 0.99 | 1.00 |
proerythroblast | 4120 | 0.66 | 0.68 | 0.85 | 0.82 | 0.00 | 0.83 | 0.66 | 0.73 | 0.82 |
kidney proximal convoluted tubule epithelial cell | 4029 | 0.86 | 0.82 | 0.89 | 0.89 | 0.00 | 0.89 | 0.92 | 0.91 | 0.92 |
endothelial cell of coronary artery | 2960 | 0.77 | 0.81 | 0.81 | 0.89 | 0.00 | 0.98 | 0.97 | 0.91 | 0.98 |
epithelial cell of proximal tubule | 2746 | 0.80 | 0.71 | 0.84 | 0.83 | 0.00 | 0.85 | 0.89 | 0.87 | 0.89 |
bladder cell | 2704 | 0.97 | 0.97 | 1.00 | 0.88 | 0.00 | 0.91 | 0.99 | 0.97 | 0.99 |
mature NK T cell | 2686 | 0.67 | 0.69 | 0.68 | 0.82 | 0.00 | 0.80 | 0.70 | 0.76 | 0.85 |
hepatocyte | 2626 | 0.99 | 1.00 | 0.99 | 0.99 | 0.00 | 0.99 | 1.00 | 0.99 | 1.00 |
erythroblast | 2646 | 0.70 | 0.72 | 0.84 | 0.87 | 0.00 | 0.91 | 0.76 | 0.81 | 0.87 |
promonocyte | 2542 | 0.81 | 0.78 | 0.88 | 0.91 | 0.00 | 0.91 | 0.91 | 0.90 | 0.93 |
stromal cell | 2511 | 0.71 | 0.01 | 0.98 | 0.77 | 0.00 | 0.83 | 0.94 | 0.81 | 0.93 |
megakaryocyte-erythroid progenitor cell | 2444 | 0.70 | 0.73 | 0.83 | 0.84 | 0.00 | 0.87 | 0.76 | 0.77 | 0.86 |
type B pancreatic cell | 2405 | 0.92 | 0.64 | 0.92 | 0.99 | 0.00 | 0.98 | 1.00 | 1.00 | 1.00 |
Kupffer cell | 2283 | 0.97 | 0.39 | 0.84 | 0.91 | 0.00 | 0.98 | 0.99 | 0.98 | 0.99 |
natural killer cell | 2217 | 0.85 | 0.84 | 0.76 | 0.87 | 0.00 | 0.89 | 0.89 | 0.90 | 0.92 |
professional antigen presenting cell | 2208 | 0.00 | 0.00 | 0.31 | 0.35 | 0.00 | 0.97 | 0.56 | 0.50 | 0.46 |
fibroblast of cardiac tissue | 2162 | 0.98 | 0.97 | 0.97 | 0.80 | 0.00 | 0.93 | 0.99 | 0.96 | 1.00 |
monocyte | 2147 | 0.77 | 0.45 | 0.87 | 0.85 | 0.00 | 0.92 | 0.92 | 0.88 | 0.93 |
bronchial smooth muscle cell | 2118 | 0.97 | 0.97 | 0.85 | 0.96 | 0.00 | 0.98 | 0.98 | 0.97 | 0.99 |
hematopoietic precursor cell | 1934 | 0.57 | 0.68 | 0.67 | 0.83 | 0.00 | 0.91 | 0.74 | 0.84 | 0.90 |
pancreatic acinar cell | 1912 | 0.98 | 0.97 | 0.91 | 1.00 | 0.00 | 0.99 | 1.00 | 0.99 | 1.00 |
skeletal muscle satellite cell | 1872 | 0.98 | 0.98 | 0.99 | 0.98 | 0.00 | 0.99 | 0.98 | 0.97 | 0.99 |
DN4 thymocyte | 1805 | 0.28 | 0.01 | 0.58 | 0.67 | 0.00 | 0.95 | 0.66 | 0.65 | 0.79 |
luminal epithelial cell of mammary gland | 1723 | 0.93 | 0.88 | 0.97 | 0.96 | 0.00 | 0.97 | 0.98 | 0.97 | 0.98 |
mesenchymal stem cell of adipose tissue | 1705 | 0.57 | 0.16 | 0.87 | 0.69 | 0.00 | 0.97 | 0.93 | 0.79 | 0.94 |
thymocyte | 1717 | 0.98 | 0.13 | 0.93 | 0.98 | 0.00 | 0.98 | 0.99 | 0.97 | 0.99 |
myeloid cell | 1637 | 0.57 | 0.01 | 0.73 | 0.70 | 0.00 | 0.96 | 0.89 | 0.83 | 0.92 |
fibroblast | 1634 | 0.63 | 0.05 | 0.79 | 0.77 | 0.00 | 0.73 | 0.79 | 0.81 | 0.87 |
immature T cell | 1612 | 0.91 | 0.37 | 0.94 | 0.97 | 0.00 | 0.97 | 0.97 | 0.94 | 0.97 |
intermediate monocyte | 1573 | 0.64 | 0.23 | 0.69 | 0.78 | 0.00 | 0.71 | 0.65 | 0.65 | 0.81 |
epidermal cell | 1560 | 0.93 | 0.00 | 0.94 | 0.94 | 0.00 | 0.93 | 0.90 | 0.89 | 0.96 |
chondrocyte | 1470 | 0.84 | 0.00 | 0.89 | 0.88 | 0.00 | 0.89 | 0.92 | 0.92 | 0.93 |
plasma cell | 1468 | 0.63 | 0.65 | 0.80 | 0.82 | 0.00 | 0.71 | 0.69 | 0.74 | 0.84 |
smooth muscle cell | 1430 | 0.74 | 0.81 | 0.88 | 0.93 | 0.00 | 0.88 | 0.90 | 0.85 | 0.85 |
lymphocyte | 1444 | 0.24 | 0.20 | 0.67 | 0.52 | 0.00 | 0.81 | 0.40 | 0.52 | 0.73 |
basal cell | 1431 | 0.98 | 0.97 | 0.99 | 0.98 | 0.00 | 0.98 | 0.99 | 0.97 | 0.99 |
naive T cell | 1417 | 0.78 | 0.91 | 0.94 | 0.94 | 0.00 | 0.91 | 0.91 | 0.91 | 0.93 |
kidney loop of Henle thick ascending limb epithelial cell | 1402 | 0.93 | 0.93 | 0.94 | 0.93 | 0.00 | 0.92 | 0.97 | 0.96 | 0.95 |
fibroblast of lung | 1377 | 0.94 | 0.91 | 0.95 | 0.97 | 0.00 | 0.99 | 0.99 | 0.98 | 0.99 |
leukocyte | 1354 | 0.64 | 0.53 | 0.74 | 0.68 | 0.00 | 0.91 | 0.83 | 0.81 | 0.93 |
alveolar macrophage | 1235 | 0.98 | 0.96 | 0.98 | 0.97 | 0.00 | 0.97 | 0.98 | 0.97 | 0.99 |
lung macrophage | 1030 | 0.89 | 0.03 | 0.79 | 0.87 | 0.00 | 0.95 | 0.90 | 0.89 | 0.96 |
enterocyte of epithelium of large intestine | 1027 | 0.95 | 0.00 | 0.94 | 0.96 | 0.00 | 0.97 | 1.00 | 0.99 | 1.00 |
non-classical monocyte | 917 | 0.77 | 0.78 | 0.90 | 0.91 | 0.00 | 0.90 | 0.90 | 0.86 | 0.89 |
double negative thymocyte | 891 | 0.72 | 0.00 | 0.65 | 0.86 | 0.00 | 0.88 | 0.91 | 0.86 | 0.93 |
precursor B cell | 807 | 0.78 | 0.85 | 0.86 | 0.95 | 0.00 | 0.94 | 0.96 | 0.95 | 0.95 |
mesenchymal cell | 781 | 0.26 | 0.00 | 0.44 | 0.31 | 0.00 | 0.40 | 0.55 | 0.62 | 0.62 |
CD8-positive, alpha-beta T cell | 792 | 0.49 | 0.55 | 0.43 | 0.69 | 0.00 | 0.84 | 0.80 | 0.81 | 0.91 |
immature B cell | 741 | 0.94 | 0.89 | 0.94 | 0.93 | 0.00 | 0.90 | 0.69 | 0.87 | 0.94 |
kidney collecting duct principal cell | 721 | 0.65 | 0.94 | 0.96 | 0.96 | 0.00 | 0.91 | 0.99 | 0.98 | 0.98 |
kidney distal convoluted tubule epithelial cell | 675 | 0.00 | 0.92 | 0.93 | 0.94 | 0.00 | 0.94 | 0.98 | 0.98 | 0.96 |
endocardial cell | 615 | 0.89 | 0.90 | 0.92 | 0.93 | 0.00 | 0.95 | 0.96 | 0.85 | 0.98 |
endothelial cell of hepatic sinusoid | 622 | 0.97 | 0.95 | 0.82 | 0.90 | 0.00 | 0.87 | 0.99 | 0.98 | 0.99 |
neutrophil | 490 | 0.64 | 0.57 | 0.95 | 0.92 | 0.00 | 0.94 | 0.95 | 0.86 | 0.95 |
CD4-positive, alpha-beta T cell | 502 | 0.00 | 0.28 | 0.51 | 0.63 | 0.00 | 0.69 | 0.59 | 0.58 | 0.88 |
late pro-B cell | 473 | 0.77 | 0.76 | 0.67 | 0.87 | 0.00 | 0.91 | 0.91 | 0.89 | 0.96 |
adventitial cell | 479 | 0.78 | 0.54 | 0.94 | 0.67 | 0.00 | 0.71 | 0.90 | 0.78 | 0.95 |
basal epithelial cell of tracheobronchial tree | 473 | 0.95 | 0.00 | 0.99 | 0.90 | 0.00 | 0.99 | 0.98 | 0.97 | 0.99 |
plasmatocyte | 457 | 0.74 | 0.81 | 0.92 | 0.89 | 0.00 | 0.66 | 0.91 | 0.92 | 0.97 |
keratinocyte stem cell | 376 | 0.87 | 0.00 | 0.94 | 0.93 | 0.00 | 0.90 | 0.91 | 0.76 | 0.97 |
brush cell | 379 | 0.91 | 0.76 | 0.95 | 0.92 | 0.00 | 0.92 | 0.92 | 0.88 | 0.97 |
erythroid progenitor cell, mammalian | 372 | 0.79 | 0.00 | 0.93 | 0.81 | 0.00 | 0.33 | 0.80 | 0.64 | 0.94 |
naive B cell | 360 | 0.88 | 0.90 | 0.95 | 0.94 | 0.00 | 0.87 | 0.93 | 0.96 | 0.96 |
kidney cortex artery cell | 344 | 0.80 | 0.88 | 0.83 | 0.77 | 0.00 | 0.68 | 0.81 | 0.73 | 0.86 |
erythrocyte | 326 | 0.74 | 0.47 | 0.85 | 0.92 | 0.00 | 0.78 | 0.88 | 0.80 | 0.94 |
intestinal crypt stem cell | 310 | 0.68 | 0.00 | 0.87 | 0.88 | 0.00 | 0.79 | 1.00 | 0.99 | 0.99 |
epithelial cell | 308 | 0.70 | 0.02 | 0.93 | 0.85 | 0.00 | 0.91 | 0.95 | 0.91 | 0.97 |
pancreatic ductal cell | 307 | 0.82 | 0.56 | 0.96 | 0.95 | 0.00 | 0.95 | 0.97 | 0.94 | 0.97 |
cardiac muscle cell | 302 | 1.00 | 1.00 | 1.00 | 0.99 | 0.00 | 0.90 | 1.00 | 0.99 | 1.00 |
vein endothelial cell | 288 | 0.57 | 0.79 | 0.84 | 0.82 | 0.00 | 0.84 | 0.92 | 0.88 | 0.94 |
pancreatic A cell | 272 | 0.00 | 0.00 | 0.71 | 0.92 | 0.00 | 0.95 | 0.99 | 0.98 | 0.99 |
myeloid leukocyte | 278 | 0.51 | 0.06 | 0.89 | 0.51 | 0.00 | 0.94 | 0.69 | 0.87 | 0.96 |
Schwann cell | 252 | 0.75 | 0.23 | 0.95 | 0.90 | 0.00 | 0.95 | 0.89 | 0.85 | 0.91 |
pancreatic D cell | 250 | 0.39 | 0.16 | 0.87 | 0.95 | 0.00 | 0.93 | 0.99 | 0.99 | 0.97 |
mesangial cell | 233 | 0.00 | 0.84 | 0.77 | 0.85 | 0.00 | 0.75 | 0.94 | 0.93 | 0.98 |
basophil | 226 | 0.59 | 0.63 | 0.89 | 0.86 | 0.00 | 0.78 | 0.78 | 0.81 | 0.86 |
myeloid dendritic cell | 208 | 0.33 | 0.64 | 0.84 | 0.62 | 0.00 | 0.64 | 0.81 | 0.78 | 0.93 |
epithelial cell of large intestine | 204 | 0.00 | 0.00 | 0.72 | 0.81 | 0.00 | 0.85 | 0.99 | 0.96 | 0.97 |
pulmonary interstitial fibroblast | 197 | 0.88 | 0.86 | 0.96 | 0.96 | 0.00 | 0.95 | 0.89 | 0.97 | 0.98 |
kidney loop of Henle ascending limb epithelial cell | 180 | 0.00 | 0.23 | 0.41 | 0.16 | 0.00 | 0.63 | 0.82 | 0.81 | 0.54 |
cell of skeletal muscle | 179 | 0.98 | 0.94 | 0.98 | 0.95 | 0.00 | 0.74 | 0.98 | 0.97 | 0.98 |
Langerhans cell | 162 | 0.92 | 0.79 | 0.97 | 0.86 | 0.00 | 0.84 | 0.96 | 0.87 | 1.00 |
stem cell of epidermis | 162 | 0.68 | 0.00 | 0.81 | 0.84 | 0.00 | 0.40 | 0.91 | 0.78 | 0.93 |
kidney capillary endothelial cell | 142 | 0.23 | 0.34 | 0.46 | 0.35 | 0.00 | 0.24 | 0.30 | 0.30 | 0.28 |
large intestine goblet cell | 140 | 0.00 | 0.00 | 0.94 | 0.97 | 0.00 | 0.87 | 1.00 | 1.00 | 1.00 |
pancreatic PP cell | 143 | 0.00 | 0.00 | 0.71 | 0.90 | 0.00 | 0.93 | 0.99 | 0.98 | 0.99 |
macrophage dendritic cell progenitor | 123 | 0.00 | 0.20 | 0.41 | 0.79 | 0.00 | 0.79 | 0.86 | 0.84 | 0.87 |
DN3 thymocyte | 131 | 0.83 | 0.49 | 0.87 | 0.91 | 0.00 | 0.96 | 0.97 | 0.91 | 0.97 |
smooth muscle cell of trachea | 116 | 0.00 | 0.00 | 0.50 | 0.55 | 0.00 | 0.81 | 0.89 | 0.88 | 0.86 |
regulatory T cell | 112 | 0.00 | 0.05 | 0.18 | 0.38 | 0.00 | 0.49 | 0.56 | 0.42 | 0.77 |
plasmacytoid dendritic cell | 100 | 0.38 | 0.32 | 0.45 | 0.78 | 0.00 | 0.77 | 0.87 | 0.81 | 0.92 |
smooth muscle cell of the pulmonary artery | 92 | 0.00 | 0.67 | 0.88 | 0.70 | 0.00 | 0.73 | 0.96 | 0.84 | 0.93 |
kidney proximal straight tubule epithelial cell | 88 | 0.00 | 0.00 | 0.14 | 0.02 | 0.00 | 0.66 | 0.61 | 0.48 | 0.41 |
blood cell | 77 | 0.00 | 0.00 | 0.39 | 0.34 | 0.00 | 0.27 | 0.44 | 0.36 | 0.57 |
immature NK T cell | 78 | 0.29 | 0.06 | 0.66 | 0.66 | 0.00 | 0.31 | 0.50 | 0.56 | 0.77 |
cardiac neuron | 74 | 0.00 | 0.27 | 0.92 | 0.72 | 0.00 | 0.78 | 0.76 | 0.91 | 0.96 |
mast cell | 72 | 0.00 | 0.00 | 0.87 | 0.76 | 0.00 | 0.73 | 0.86 | 0.78 | 0.94 |
pericyte | 53 | 0.98 | 0.85 | 0.92 | 0.92 | 0.00 | 0.97 | 0.63 | 0.94 | 0.99 |
ciliated columnar cell of tracheobronchial tree | 54 | 0.00 | 0.05 | 0.69 | 0.95 | 0.00 | 0.93 | 0.41 | 1.00 | 0.97 |
neuroendocrine cell | 41 | 0.00 | 0.00 | 0.25 | 0.28 | 0.00 | 0.76 | 0.99 | 0.76 | 0.61 |
dendritic cell | 37 | 0.00 | 0.00 | 0.59 | 0.49 | 0.00 | 0.30 | 0.79 | 0.69 | 0.93 |
endothelial cell of lymphatic vessel | 38 | 0.00 | 0.30 | 0.93 | 0.65 | 0.00 | 0.20 | 0.75 | 0.52 | 0.97 |
hepatic stellate cell | 36 | 0.00 | 0.05 | 0.81 | 0.91 | 0.00 | 0.48 | 0.99 | 0.99 | 0.99 |
hematopoietic stem cell | 31 | 0.00 | 0.00 | 0.28 | 0.73 | 0.00 | 0.45 | 0.78 | 0.87 | 0.97 |
kidney collecting duct epithelial cell | 23 | 0.00 | 0.00 | 0.08 | 0.00 | 0.00 | 0.73 | 1.00 | 0.92 | 0.16 |
pancreatic stellate cell | 20 | 0.00 | 0.00 | 0.71 | 0.26 | 0.00 | 0.23 | 0.89 | 1.00 | 0.97 |
club cell | 14 | 0.07 | 0.00 | 0.25 | 0.11 | 0.00 | 0.17 | 0.21 | 0.20 | 0.15 |
lung neuroendocrine cell | 3 | 0.00 | 0.00 | 1.00 | 0.80 | 0.00 | 0.60 | 0.03 | 1.00 | 1.00 |
kidney cell | 3 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.02 | 0.86 | 0.80 |
duct epithelial cell | 2 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.57 | 1.00 | 0.07 | 0.00 |
References
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