Dataset Viewer
protein_id
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10
| protein_names
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2.59k
| protein_function
large_stringlengths 13
15.4k
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large_stringlengths 9
178
⌀ | length
float64 3
35.4k
⌀ | subcellular_location
large_stringlengths 7
6.16k
⌀ | sequence
large_stringlengths 3
35.4k
⌀ | go_ids
large listlengths 2
815
| go_bp
large listlengths 2
708
⌀ | go_mf
large listlengths 2
83
⌀ | go_cc
large listlengths 2
102
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large listlengths 1
82
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large_stringlengths 21
38
⌀ | string_id
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1.44k
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A0A087X1C5
|
Putative cytochrome P450 2D7 (EC 1.14.14.1)
|
May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine (PubMed:15051713). However, another study could not confirm it (PubMed:18838503). {ECO:0000269|PubMed:15051713, ECO:0000269|PubMed:18838503}.
|
Homo sapiens (Human)
| 515 |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000305|PubMed:15051713}. Mitochondrion {ECO:0000269|PubMed:18838503}.
|
MGLEALVPLAMIVAIFLLLVDLMHRHQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPAPIYQVLGFGPRSQGVILSRYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFADQAGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLPHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAKKEKAKGSPESSFNDENLRIVVGNLFLAGMVTTSTTLAWGLLLMILHLDVQRGRRVSPGCPIVGTHVCPVRVQQEIDDVIGQVRRPEMGDQAHMPCTTAVIHEVQHFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWKKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAGQPRPSHSRVVSFLVTPSPYELCAVPR
|
[
"GO:0008152",
"GO:0051716",
"GO:0009987",
"GO:0071466",
"GO:0044237",
"GO:0006805",
"GO:0008150",
"GO:0042221",
"GO:0050896",
"GO:0009410",
"GO:0009056",
"GO:0070887",
"GO:0044248",
"GO:0042178",
"GO:0005622",
"GO:0043229",
"GO:0043226",
"GO:0110165",
"GO:0005739",
"GO:0005737",
"GO:0005575",
"GO:0043227",
"GO:0043231",
"GO:0003674",
"GO:0070330",
"GO:0016705",
"GO:0003824",
"GO:0004497",
"GO:0016491",
"GO:0016712"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0050896",
"GO:0051716",
"GO:0044237",
"GO:0042221",
"GO:0009056",
"GO:0006805",
"GO:0009410",
"GO:0070887",
"GO:0044248",
"GO:0071466",
"GO:0042178"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016491",
"GO:0016705",
"GO:0004497",
"GO:0016712",
"GO:0070330"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0005622",
"GO:0043226",
"GO:0005737",
"GO:0043229",
"GO:0005739",
"GO:0043227",
"GO:0043231"
] |
[
"IPR001128",
"IPR017972",
"IPR002401",
"IPR008069",
"IPR036396",
"IPR050182"
] |
af_db/AF-A0A087X1C5-F1-model_v4.cif.gz
| null | null | null |
A0A0B4J2F0
|
Protein PIGBOS1 (PIGB opposite strand protein 1)
|
Plays a role in regulation of the unfolded protein response triggered by endoplasmic reticulum (ER) stress resulting from the presence of unfolded proteins in the ER lumen. {ECO:0000269|PubMed:31653868}.
|
Homo sapiens (Human)
| 54 |
Mitochondrion outer membrane {ECO:0000269|PubMed:31653868}; Single-pass membrane protein {ECO:0000255}.
|
MFRRLTFAQLLFATVLGIAGGVYIFQPVFEQYAKDQKELKEKMQLVQESEEKKS
|
[
"GO:0048583",
"GO:0050789",
"GO:0010646",
"GO:0023051",
"GO:0080135",
"GO:0065007",
"GO:0080134",
"GO:0050794",
"GO:1905897",
"GO:0008150",
"GO:1900101",
"GO:0009966",
"GO:0005622",
"GO:0031090",
"GO:0031967",
"GO:0043226",
"GO:0005739",
"GO:0031975",
"GO:0005575",
"GO:0005740",
"GO:0016020",
"GO:0031968",
"GO:0043231",
"GO:0005741",
"GO:0098588",
"GO:0043229",
"GO:0110165",
"GO:0019867",
"GO:0005737",
"GO:0043227",
"GO:0031966",
"GO:0005515",
"GO:0005488",
"GO:0003674"
] |
[
"GO:0008150",
"GO:0050789",
"GO:0065007",
"GO:0048583",
"GO:0023051",
"GO:0050794",
"GO:0010646",
"GO:0080135",
"GO:0080134",
"GO:0009966",
"GO:1905897",
"GO:1900101"
] |
[
"GO:0003674",
"GO:0005488",
"GO:0005515"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0005622",
"GO:0043226",
"GO:0031975",
"GO:0016020",
"GO:0005737",
"GO:0031090",
"GO:0031967",
"GO:0005739",
"GO:0043229",
"GO:0019867",
"GO:0043227",
"GO:0005740",
"GO:0031968",
"GO:0043231",
"GO:0098588",
"GO:0031966",
"GO:0005741"
] | null |
af_db/AF-A0A0B4J2F0-F1-model_v4.cif.gz
|
9606.ENSP00000484893
| null | null |
A0A0A7EPL0
|
E4 SUMO-protein ligase PIAL1 (EC 2.3.2.-) (Protein EMBRYO DEFECTIVE 3001) (Protein INHIBITOR OF ACTIVATED STAT-LIKE 1)
|
Together with MOM1 and PIAL2, regulates transcriptional gene silencing (TGS) independently of changes in DNA methylation (PubMed:27113777). E4-type SUMO ligase that promotes SUMO chain formation in a SCE1-dependent manner and thus contributes to a pathway for proteolytic removal of sumoylation substrates (PubMed:25415977). Involved in stress responses (e.g. osmotic, salt and abscisic acid ABA) and sulfur metabolism (PubMed:25415977). {ECO:0000269|PubMed:25415977, ECO:0000269|PubMed:27113777}.
|
Arabidopsis thaliana (Mouse-ear cress)
| 847 |
Nucleus {ECO:0000305}.
|
MVIPATSRFGFRAEFNTKEFQASCISLANEIDAAIGRNEVPGNIQELALILNNVCRRKCDDYQTRAVVMALMISVKSACQLGWFPERETQELLAIIDLMWNGFSCPENVTSCVNSPVTLISQVIERFYPCVKLGHILVSFEAKPESKMMMKDFHISKKMPHSPKQKVGLFVVRTEDISRSNCIVHPQGVSFLLNGKGIDKRVNISMESGPQLPTNVTALLNLGANLLQAIGCFGGSYLIAIAFMDVIPLPNKPLLKDYVHPEVVGSNSDCDIIEGPSRISLSCPISRTRIKLPVKGHVCKHLQCFDFWNYVNMNTRRPSWRCPHCNQSVCYTDIRVDQKLRKILEEVGRNAADVVISADGTWMVETENDEDVELVPETTHDHGDPNSFINLGPTVKNPARDENEMETSTQVEEHNPCLSEIQGPSNDTHRPASDYTMLNQSHTSTNTLPQLPRTLNAFDGQQFVNLPQVINTRDSPASQALPMTFSPTPSPQDILATNAANFGTSMPAAQSSQFQGSHVTSLGNCEGRTSDLMARWNHIYGRVQTQFPPAPLSHHHYSMQNQSPSPAQQRPVPSYIAHPQTFHVNYGENADQRWMPSSIAHPQTLPVNYGGNTNQRPIPSSIAHPQTLPVNYRGNTDHRSTPYSITHLQTLLNYGGNADQRPMPSSITNLQTLPATYGGYAHQRPMSSSITHPRTSPVNYGGTPDQRPMPSSITHPQTLPVSYGGTTDQILNPGGAMGQFSSREFMNLTPANTENWRPQSRMRGSVAPGTGYDHMIIHPTRPVHPQAQTPPAPLSTSYDGADEIQAFIGHPSYPVSNNETQAGTSSLPVAEGLGYSGSFWSMPPETW
|
[
"GO:0008152",
"GO:0036211",
"GO:0009628",
"GO:0065007",
"GO:0097305",
"GO:0048518",
"GO:0043412",
"GO:0008150",
"GO:0051176",
"GO:1901564",
"GO:0042221",
"GO:0050896",
"GO:0050789",
"GO:0031325",
"GO:0019222",
"GO:0033993",
"GO:0009719",
"GO:0019538",
"GO:0006807",
"GO:0050794",
"GO:0006970",
"GO:0009893",
"GO:0016925",
"GO:0031323",
"GO:1901700",
"GO:0009651",
"GO:0018205",
"GO:0006950",
"GO:0042762",
"GO:0009737",
"GO:0032446",
"GO:0070647",
"GO:0071704",
"GO:0043170",
"GO:0010033",
"GO:0009725",
"GO:0018193",
"GO:0044238",
"GO:0048522",
"GO:0016740",
"GO:0003674",
"GO:0140096",
"GO:0019789",
"GO:0003824",
"GO:0019787"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0065007",
"GO:0048518",
"GO:0050896",
"GO:0050789",
"GO:0009628",
"GO:0042221",
"GO:0019222",
"GO:0009719",
"GO:0006807",
"GO:0050794",
"GO:0009893",
"GO:0006950",
"GO:0071704",
"GO:0044238",
"GO:0048522",
"GO:1901564",
"GO:0031325",
"GO:0019538",
"GO:0006970",
"GO:0031323",
"GO:1901700",
"GO:0043170",
"GO:0010033",
"GO:0009725",
"GO:0036211",
"GO:0097305",
"GO:0043412",
"GO:0051176",
"GO:0033993",
"GO:0009651",
"GO:0042762",
"GO:0009737",
"GO:0070647",
"GO:0018193",
"GO:0018205",
"GO:0032446",
"GO:0016925"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016740",
"GO:0140096",
"GO:0019787",
"GO:0019789"
] | null |
[
"IPR004181",
"IPR013083"
] |
af_db/AF-A0A0A7EPL0-F1-model_v4.cif.gz
|
3702.A0A0A7EPL0
|
[
"3702.Q94F30",
"3702.P55852",
"3702.Q2PS26",
"3702.O65278",
"3702.B3H5R8",
"3702.Q9FLP6",
"3702.Q9M658",
"3702.Q9SJT1",
"3702.Q8RXV2",
"3702.Q8RWN0",
"3702.Q8L7S0",
"3702.F4JF18",
"3702.Q9FLP5",
"3702.Q9S7T1",
"3702.F4HPZ9",
"3702.Q9LP44",
"3702.Q8VY78",
"3702.Q0WKV8",
"3702.P35132",
"3702.F4JGS0",
"3702.Q6NMJ2",
"3702.Q42551",
"3702.Q9ZW35",
"3702.Q8GYL3",
"3702.Q9M7Q7",
"3702.Q8VZI7",
"3702.F4JYG0",
"3702.B3H615",
"3702.Q9FKC5",
"3702.Q3E8A8",
"3702.Q8GYH7",
"3702.Q9FKC6",
"3702.O22227",
"3702.P0DI12"
] |
[
{
"protein2": "3702.Q94F30",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 107,
"database": 0,
"textmining": 811,
"combined_score": 823
},
{
"protein2": "3702.P55852",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 558,
"database": 415,
"textmining": 854,
"combined_score": 958
},
{
"protein2": "3702.Q2PS26",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 107,
"database": 0,
"textmining": 795,
"combined_score": 809
},
{
"protein2": "3702.O65278",
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"coexpression": 0,
"experimental": 107,
"database": 0,
"textmining": 795,
"combined_score": 809
},
{
"protein2": "3702.B3H5R8",
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"coexpression": 0,
"experimental": 558,
"database": 415,
"textmining": 469,
"combined_score": 850
},
{
"protein2": "3702.Q9FLP6",
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"experimental": 558,
"database": 415,
"textmining": 831,
"combined_score": 952
},
{
"protein2": "3702.Q9M658",
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"textmining": 872,
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{
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"textmining": 937,
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{
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"database": 415,
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"combined_score": 776
},
{
"protein2": "3702.Q8RWN0",
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"experimental": 107,
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"textmining": 817,
"combined_score": 829
},
{
"protein2": "3702.Q8L7S0",
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"experimental": 107,
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"combined_score": 782
},
{
"protein2": "3702.F4JF18",
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},
{
"protein2": "3702.Q9FLP5",
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"experimental": 558,
"database": 415,
"textmining": 800,
"combined_score": 943
},
{
"protein2": "3702.Q9S7T1",
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"experimental": 78,
"database": 0,
"textmining": 785,
"combined_score": 793
},
{
"protein2": "3702.F4HPZ9",
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"cooccurence": 0,
"coexpression": 53,
"experimental": 71,
"database": 331,
"textmining": 663,
"combined_score": 775
},
{
"protein2": "3702.Q9LP44",
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},
{
"protein2": "3702.Q8VY78",
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"experimental": 75,
"database": 0,
"textmining": 920,
"combined_score": 923
},
{
"protein2": "3702.Q0WKV8",
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"coexpression": 53,
"experimental": 0,
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"textmining": 718,
"combined_score": 721
},
{
"protein2": "3702.P35132",
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"cooccurence": 0,
"coexpression": 0,
"experimental": 307,
"database": 266,
"textmining": 519,
"combined_score": 733
},
{
"protein2": "3702.F4JGS0",
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"cooccurence": 0,
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"experimental": 45,
"database": 0,
"textmining": 795,
"combined_score": 795
},
{
"protein2": "3702.Q6NMJ2",
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"textmining": 752,
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},
{
"protein2": "3702.Q42551",
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"cooccurence": 0,
"coexpression": 0,
"experimental": 886,
"database": 681,
"textmining": 956,
"combined_score": 998
},
{
"protein2": "3702.Q9ZW35",
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"cooccurence": 0,
"coexpression": 50,
"experimental": 733,
"database": 0,
"textmining": 211,
"combined_score": 782
},
{
"protein2": "3702.Q8GYL3",
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"experimental": 107,
"database": 0,
"textmining": 795,
"combined_score": 809
},
{
"protein2": "3702.Q9M7Q7",
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"cooccurence": 0,
"coexpression": 50,
"experimental": 733,
"database": 0,
"textmining": 211,
"combined_score": 782
},
{
"protein2": "3702.Q8VZI7",
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"experimental": 558,
"database": 415,
"textmining": 831,
"combined_score": 952
},
{
"protein2": "3702.F4JYG0",
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"coexpression": 110,
"experimental": 0,
"database": 900,
"textmining": 474,
"combined_score": 949
},
{
"protein2": "3702.B3H615",
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"coexpression": 63,
"experimental": 0,
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"textmining": 712,
"combined_score": 718
},
{
"protein2": "3702.Q9FKC5",
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"experimental": 558,
"database": 415,
"textmining": 749,
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},
{
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"experimental": 558,
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},
{
"protein2": "3702.Q8GYH7",
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"experimental": 616,
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},
{
"protein2": "3702.Q9FKC6",
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"experimental": 558,
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},
{
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},
{
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"experimental": 75,
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}
] |
A0A0B4J1G0
|
Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-2) (FcgammaRIV) (CD antigen CD16a)
|
Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (PubMed:16039578). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:16039578). Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC). Confers protection to lethal influenza virus infection (PubMed:24412922). On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses (PubMed:28389502). Mediates neutrophil activation by IgG complexes redundantly with FCGR2A (PubMed:18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719). Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE) (PubMed:17558411, PubMed:18949059). Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059). Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821). {ECO:0000269|PubMed:16039578, ECO:0000269|PubMed:17558411, ECO:0000269|PubMed:18097064, ECO:0000269|PubMed:18949059, ECO:0000269|PubMed:19795417, ECO:0000269|PubMed:24412922, ECO:0000269|PubMed:25824719, ECO:0000269|PubMed:28389502, ECO:0000269|PubMed:34485821}.
|
Mus musculus (Mouse)
| 249 |
Cell membrane {ECO:0000269|PubMed:16039578, ECO:0000269|PubMed:17558411, ECO:0000269|PubMed:28389502}; Single-pass type I membrane protein {ECO:0000255}.
|
MWQLLLPTALVLTAFSGIQAGLQKAVVNLDPKWVRVLEEDSVTLRCQGTFSPEDNSIKWFHNESLIPHQDANYVIQSARVKDSGMYRCQTALSTISDPVQLEVHMGWLLLQTTKWLFQEGDPIHLRCHSWQNRPVRKVTYLQNGKGKKYFHENSELLIPKATHNDSGSYFCRGLIGHNNKSSASFRISLGDPGSPSMFPPWHQITFCLLIGLLFAIDTVLYFSVRRGLQSPVADYEEPKIQWSKEPQDK
|
[
"GO:0006898",
"GO:0051234",
"GO:0002376",
"GO:0045780",
"GO:0046850",
"GO:0009987",
"GO:0065007",
"GO:0045124",
"GO:0001775",
"GO:0051179",
"GO:0051239",
"GO:0002274",
"GO:0016192",
"GO:0048518",
"GO:0031503",
"GO:0008150",
"GO:0036230",
"GO:0045321",
"GO:0006897",
"GO:0019882",
"GO:0160006",
"GO:0050789",
"GO:0042119",
"GO:0051240",
"GO:0032501",
"GO:0006810",
"GO:0034103",
"GO:0002468",
"GO:0071944",
"GO:0005575",
"GO:0110165",
"GO:0016020",
"GO:0005886",
"GO:0009986",
"GO:0019767",
"GO:0004888",
"GO:0038023",
"GO:0019763",
"GO:0140375",
"GO:0003674",
"GO:0060089",
"GO:0019770"
] |
[
"GO:0008150",
"GO:0002376",
"GO:0009987",
"GO:0065007",
"GO:0051179",
"GO:0048518",
"GO:0050789",
"GO:0032501",
"GO:0051234",
"GO:0001775",
"GO:0051239",
"GO:0031503",
"GO:0045321",
"GO:0019882",
"GO:0051240",
"GO:0045780",
"GO:0002274",
"GO:0160006",
"GO:0006810",
"GO:0034103",
"GO:0002468",
"GO:0046850",
"GO:0016192",
"GO:0036230",
"GO:0045124",
"GO:0006897",
"GO:0042119",
"GO:0006898"
] |
[
"GO:0003674",
"GO:0060089",
"GO:0038023",
"GO:0004888",
"GO:0140375",
"GO:0019763",
"GO:0019767",
"GO:0019770"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0071944",
"GO:0016020",
"GO:0009986",
"GO:0005886"
] |
[
"IPR007110",
"IPR036179",
"IPR013783",
"IPR050488",
"IPR003599",
"IPR003598"
] |
af_db/AF-A0A0B4J1G0-F1-model_v4.cif.gz
|
10090.ENSMUSP00000077873
|
[
"10090.ENSMUSP00000141397",
"10090.ENSMUSP00000005889",
"10090.ENSMUSP00000032800",
"10090.ENSMUSP00000140926",
"10090.ENSMUSP00000027966",
"10090.ENSMUSP00000042636",
"10090.ENSMUSP00000104255",
"10090.ENSMUSP00000113091",
"10090.ENSMUSP00000029748",
"10090.ENSMUSP00000070073",
"10090.ENSMUSP00000131938",
"10090.ENSMUSP00000077546",
"10090.ENSMUSP00000077833",
"10090.ENSMUSP00000003370",
"10090.ENSMUSP00000113852",
"10090.ENSMUSP00000024044",
"10090.ENSMUSP00000041306",
"10090.ENSMUSP00000038838",
"10090.ENSMUSP00000127373",
"10090.ENSMUSP00000121707",
"10090.ENSMUSP00000141504",
"10090.ENSMUSP00000068468",
"10090.ENSMUSP00000078875",
"10090.ENSMUSP00000002101"
] |
[
{
"protein2": "10090.ENSMUSP00000141397",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 139,
"experimental": 414,
"database": 0,
"textmining": 490,
"combined_score": 719
},
{
"protein2": "10090.ENSMUSP00000005889",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 337,
"experimental": 0,
"database": 500,
"textmining": 188,
"combined_score": 707
},
{
"protein2": "10090.ENSMUSP00000032800",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 527,
"experimental": 0,
"database": 0,
"textmining": 543,
"combined_score": 774
},
{
"protein2": "10090.ENSMUSP00000140926",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 42,
"experimental": 0,
"database": 900,
"textmining": 466,
"combined_score": 944
},
{
"protein2": "10090.ENSMUSP00000027966",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 235,
"experimental": 0,
"database": 400,
"textmining": 526,
"combined_score": 763
},
{
"protein2": "10090.ENSMUSP00000042636",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 128,
"experimental": 0,
"database": 800,
"textmining": 0,
"combined_score": 818
},
{
"protein2": "10090.ENSMUSP00000104255",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 146,
"experimental": 0,
"database": 800,
"textmining": 192,
"combined_score": 849
},
{
"protein2": "10090.ENSMUSP00000113091",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 172,
"experimental": 0,
"database": 800,
"textmining": 80,
"combined_score": 834
},
{
"protein2": "10090.ENSMUSP00000029748",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 531,
"experimental": 104,
"database": 900,
"textmining": 795,
"combined_score": 990
},
{
"protein2": "10090.ENSMUSP00000070073",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 112,
"experimental": 0,
"database": 800,
"textmining": 173,
"combined_score": 840
},
{
"protein2": "10090.ENSMUSP00000131938",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 56,
"coexpression": 462,
"experimental": 0,
"database": 900,
"textmining": 459,
"combined_score": 968
},
{
"protein2": "10090.ENSMUSP00000077546",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 209,
"experimental": 0,
"database": 800,
"textmining": 137,
"combined_score": 851
},
{
"protein2": "10090.ENSMUSP00000077833",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 121,
"experimental": 58,
"database": 800,
"textmining": 169,
"combined_score": 844
},
{
"protein2": "10090.ENSMUSP00000003370",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 256,
"experimental": 77,
"database": 900,
"textmining": 287,
"combined_score": 944
},
{
"protein2": "10090.ENSMUSP00000113852",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 122,
"experimental": 88,
"database": 900,
"textmining": 478,
"combined_score": 952
},
{
"protein2": "10090.ENSMUSP00000024044",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 69,
"experimental": 180,
"database": 0,
"textmining": 761,
"combined_score": 801
},
{
"protein2": "10090.ENSMUSP00000041306",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 56,
"experimental": 58,
"database": 800,
"textmining": 145,
"combined_score": 827
},
{
"protein2": "10090.ENSMUSP00000038838",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 126,
"experimental": 64,
"database": 900,
"textmining": 273,
"combined_score": 932
},
{
"protein2": "10090.ENSMUSP00000127373",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 50,
"experimental": 0,
"database": 720,
"textmining": 491,
"combined_score": 852
},
{
"protein2": "10090.ENSMUSP00000121707",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 103,
"experimental": 0,
"database": 800,
"textmining": 0,
"combined_score": 812
},
{
"protein2": "10090.ENSMUSP00000141504",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 441,
"experimental": 414,
"database": 0,
"textmining": 463,
"combined_score": 808
},
{
"protein2": "10090.ENSMUSP00000068468",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 171,
"experimental": 0,
"database": 0,
"textmining": 657,
"combined_score": 703
},
{
"protein2": "10090.ENSMUSP00000078875",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 391,
"experimental": 0,
"database": 900,
"textmining": 839,
"combined_score": 989
},
{
"protein2": "10090.ENSMUSP00000002101",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 94,
"experimental": 0,
"database": 800,
"textmining": 233,
"combined_score": 848
}
] |
A0A0B4J1N3
|
Protein GPR15LG (Protein GPR15 ligand) (Protein GPR15L)
|
Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). May regulate keratinocyte proliferation. In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed:35704588). {ECO:0000250|UniProtKB:Q6UWK7, ECO:0000269|PubMed:28900043, ECO:0000269|PubMed:28936214, ECO:0000269|PubMed:35704588}.; FUNCTION: Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus. {ECO:0000250|UniProtKB:Q6UWK7}.
|
Mus musculus (Mouse)
| 78 |
Secreted {ECO:0000250|UniProtKB:Q6UWK7}.
|
MRLLALSGLLCMLLLCFCIFSSEGRRHPAKSLKLRRCCHLSPRSKLTTWKGNHTRPCRLCRNKLPVKSWVVPGALPQI
|
[
"GO:0009605",
"GO:0051716",
"GO:0040011",
"GO:0002376",
"GO:0060326",
"GO:0009987",
"GO:0048870",
"GO:0072676",
"GO:0008150",
"GO:0042221",
"GO:0071674",
"GO:0006935",
"GO:0050896",
"GO:0050900",
"GO:0042330",
"GO:0030595",
"GO:0070887",
"GO:0016477",
"GO:0048247",
"GO:0098772",
"GO:0005488",
"GO:0140677",
"GO:0005125",
"GO:0048018",
"GO:0008009",
"GO:0005102",
"GO:0005126",
"GO:0030545",
"GO:0003674",
"GO:0001664",
"GO:0030546",
"GO:0005515",
"GO:0042379"
] |
[
"GO:0008150",
"GO:0040011",
"GO:0002376",
"GO:0009987",
"GO:0050896",
"GO:0009605",
"GO:0051716",
"GO:0048870",
"GO:0042221",
"GO:0050900",
"GO:0042330",
"GO:0071674",
"GO:0006935",
"GO:0030595",
"GO:0070887",
"GO:0016477",
"GO:0060326",
"GO:0072676",
"GO:0048247"
] |
[
"GO:0003674",
"GO:0098772",
"GO:0005488",
"GO:0140677",
"GO:0030545",
"GO:0005515",
"GO:0005102",
"GO:0030546",
"GO:0048018",
"GO:0005126",
"GO:0001664",
"GO:0005125",
"GO:0042379",
"GO:0008009"
] | null |
[
"IPR031713"
] |
af_db/AF-A0A0B4J1N3-F1-model_v4.cif.gz
|
10090.ENSMUSP00000136426
|
[
"10090.ENSMUSP00000086731"
] |
[
{
"protein2": "10090.ENSMUSP00000086731",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 0,
"textmining": 792,
"combined_score": 792
}
] |
A0A096MJY4
|
Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C)
|
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes (PubMed:15862299). Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:15862299}.
|
Rattus norvegicus (Rat)
| 473 |
Nucleus {ECO:0000269|PubMed:15862299}. Cytoplasm, sarcoplasm {ECO:0000269|PubMed:15862299}.
|
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT
|
[
"GO:0009605",
"GO:0048856",
"GO:0045944",
"GO:0042981",
"GO:0048518",
"GO:0001932",
"GO:0042221",
"GO:0060548",
"GO:0010556",
"GO:0050789",
"GO:0051246",
"GO:0043069",
"GO:0071900",
"GO:0043067",
"GO:0030154",
"GO:0051240",
"GO:0021542",
"GO:0048731",
"GO:0044057",
"GO:0048513",
"GO:0071331",
"GO:0070848",
"GO:0009966",
"GO:0071495",
"GO:0060255",
"GO:0071326",
"GO:0045937",
"GO:0071333",
"GO:2001141",
"GO:0051239",
"GO:0090257",
"GO:0043502",
"GO:0033273",
"GO:0043523",
"GO:0010468",
"GO:0045859",
"GO:0032501",
"GO:0009749",
"GO:0007420",
"GO:0055082",
"GO:0065007",
"GO:0019725",
"GO:0033197",
"GO:0043549",
"GO:0007399",
"GO:0043524",
"GO:0021761",
"GO:0050896",
"GO:1903508",
"GO:0031667",
"GO:0009719",
"GO:0030900",
"GO:0072359",
"GO:0042327",
"GO:0050794",
"GO:1902680",
"GO:0051171",
"GO:0043410",
"GO:0048583",
"GO:1903506",
"GO:0051716",
"GO:0021543",
"GO:0043406",
"GO:0032502",
"GO:0023051",
"GO:0009987",
"GO:0001934",
"GO:0014742",
"GO:0007417",
"GO:1902533",
"GO:0051252",
"GO:0043085",
"GO:0048523",
"GO:1901701",
"GO:0031401",
"GO:0007507",
"GO:0043405",
"GO:0051173",
"GO:0009967",
"GO:0042325",
"GO:0021766",
"GO:0048869",
"GO:0006357",
"GO:0050790",
"GO:0023056",
"GO:0043408",
"GO:0009743",
"GO:0007275",
"GO:1901215",
"GO:0044093",
"GO:0051347",
"GO:0010562",
"GO:0045893",
"GO:0010604",
"GO:0048584",
"GO:0019222",
"GO:0021537",
"GO:0071310",
"GO:0071902",
"GO:0014743",
"GO:0033674",
"GO:0031399",
"GO:0071300",
"GO:0042592",
"GO:0033500",
"GO:1901700",
"GO:1901214",
"GO:0071322",
"GO:0043066",
"GO:0010613",
"GO:0006355",
"GO:0010033",
"GO:0009891",
"GO:0034284",
"GO:0071407",
"GO:0032526",
"GO:0019220",
"GO:0071396",
"GO:0009991",
"GO:0048878",
"GO:0010557",
"GO:0045935",
"GO:0051254",
"GO:0008150",
"GO:0010941",
"GO:0007584",
"GO:0060322",
"GO:0031325",
"GO:0010646",
"GO:0033993",
"GO:0070887",
"GO:0042593",
"GO:0009889",
"GO:0009746",
"GO:0031326",
"GO:0009893",
"GO:0010611",
"GO:0051247",
"GO:0031323",
"GO:0010647",
"GO:0019219",
"GO:0065009",
"GO:0006950",
"GO:0080090",
"GO:0014070",
"GO:0051338",
"GO:0002931",
"GO:0048519",
"GO:0045860",
"GO:0001678",
"GO:0071363",
"GO:0031328",
"GO:1902531",
"GO:0051174",
"GO:0060290",
"GO:0048522",
"GO:0099081",
"GO:0005622",
"GO:0043226",
"GO:0043292",
"GO:0005575",
"GO:0043231",
"GO:0099512",
"GO:0005829",
"GO:0030017",
"GO:0043229",
"GO:0110165",
"GO:0030016",
"GO:0043232",
"GO:0005737",
"GO:0043227",
"GO:0005634",
"GO:0043228",
"GO:0099080",
"GO:0003677",
"GO:0003676",
"GO:0005488",
"GO:0140110",
"GO:0097159",
"GO:0003674",
"GO:0003700",
"GO:1901363",
"GO:0000981",
"GO:0005515"
] |
[
"GO:0008150",
"GO:0048518",
"GO:0050789",
"GO:0032501",
"GO:0065007",
"GO:0050896",
"GO:0032502",
"GO:0009987",
"GO:0042592",
"GO:0048519",
"GO:0009605",
"GO:0048856",
"GO:0042221",
"GO:0051240",
"GO:0051239",
"GO:0019725",
"GO:0009719",
"GO:0050794",
"GO:0048583",
"GO:0051716",
"GO:0023051",
"GO:0048523",
"GO:0048869",
"GO:0023056",
"GO:0007275",
"GO:0048584",
"GO:0019222",
"GO:0048878",
"GO:0009893",
"GO:0065009",
"GO:0006950",
"GO:0048522",
"GO:0060548",
"GO:0030154",
"GO:0021542",
"GO:0048731",
"GO:0044057",
"GO:0048513",
"GO:0070848",
"GO:0009966",
"GO:0071495",
"GO:0060255",
"GO:0043502",
"GO:0055082",
"GO:0030900",
"GO:0051171",
"GO:0021543",
"GO:0014742",
"GO:0051173",
"GO:0009967",
"GO:0021766",
"GO:0050790",
"GO:0044093",
"GO:0010604",
"GO:0021537",
"GO:0033500",
"GO:1901700",
"GO:0010033",
"GO:0009891",
"GO:0009991",
"GO:0010941",
"GO:0007584",
"GO:0060322",
"GO:0031325",
"GO:0010646",
"GO:0070887",
"GO:0009889",
"GO:0031323",
"GO:0010647",
"GO:0080090",
"GO:0002931",
"GO:0010556",
"GO:0051246",
"GO:0043069",
"GO:0043067",
"GO:0090257",
"GO:0033273",
"GO:0010468",
"GO:0007420",
"GO:0033197",
"GO:0007399",
"GO:0021761",
"GO:0031667",
"GO:0072359",
"GO:0007417",
"GO:1902533",
"GO:0051252",
"GO:0043085",
"GO:1901701",
"GO:0007507",
"GO:0009743",
"GO:1901215",
"GO:0010562",
"GO:0071310",
"GO:1901214",
"GO:0010613",
"GO:0032526",
"GO:0010557",
"GO:0045935",
"GO:0051254",
"GO:0033993",
"GO:0042593",
"GO:0031326",
"GO:0010611",
"GO:0051247",
"GO:0019219",
"GO:0014070",
"GO:0051338",
"GO:0001678",
"GO:0071363",
"GO:0031328",
"GO:1902531",
"GO:0051174",
"GO:0060290",
"GO:0042981",
"GO:0045937",
"GO:0071333",
"GO:2001141",
"GO:0043523",
"GO:0043549",
"GO:0043524",
"GO:1902680",
"GO:0043410",
"GO:0031401",
"GO:0043408",
"GO:0051347",
"GO:0014743",
"GO:0031399",
"GO:0071300",
"GO:0071322",
"GO:0043066",
"GO:0006355",
"GO:0034284",
"GO:0071407",
"GO:0019220",
"GO:0071396",
"GO:0001932",
"GO:0071326",
"GO:0045859",
"GO:1903508",
"GO:0042327",
"GO:1903506",
"GO:0043406",
"GO:0001934",
"GO:0042325",
"GO:0006357",
"GO:0045893",
"GO:0033674",
"GO:0009746",
"GO:0045944",
"GO:0071900",
"GO:0071331",
"GO:0009749",
"GO:0045860",
"GO:0043405",
"GO:0071902"
] |
[
"GO:0003674",
"GO:0005488",
"GO:0140110",
"GO:0097159",
"GO:0003700",
"GO:1901363",
"GO:0005515",
"GO:0003676",
"GO:0000981",
"GO:0003677"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0005622",
"GO:0043226",
"GO:0005829",
"GO:0030017",
"GO:0005737",
"GO:0099080",
"GO:0099081",
"GO:0043292",
"GO:0043229",
"GO:0043227",
"GO:0043228",
"GO:0043231",
"GO:0099512",
"GO:0030016",
"GO:0043232",
"GO:0005634"
] |
[
"IPR022102",
"IPR033896",
"IPR002100",
"IPR036879"
] |
af_db/AF-A0A096MJY4-F1-model_v4.cif.gz
|
10116.ENSRNOP00000068323
|
[
"10116.ENSRNOP00000012854",
"10116.ENSRNOP00000009325",
"10116.ENSRNOP00000027622",
"10116.ENSRNOP00000014320",
"10116.ENSRNOP00000068620",
"10116.ENSRNOP00000006453",
"10116.ENSRNOP00000017305",
"10116.ENSRNOP00000052059",
"10116.ENSRNOP00000046455",
"10116.ENSRNOP00000069434",
"10116.ENSRNOP00000000617",
"10116.ENSRNOP00000072988",
"10116.ENSRNOP00000015109",
"10116.ENSRNOP00000073308",
"10116.ENSRNOP00000001659",
"10116.ENSRNOP00000074299",
"10116.ENSRNOP00000001893",
"10116.ENSRNOP00000006523",
"10116.ENSRNOP00000028155"
] |
[
{
"protein2": "10116.ENSRNOP00000012854",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 50,
"experimental": 172,
"database": 0,
"textmining": 771,
"combined_score": 803
},
{
"protein2": "10116.ENSRNOP00000009325",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 57,
"experimental": 360,
"database": 500,
"textmining": 293,
"combined_score": 758
},
{
"protein2": "10116.ENSRNOP00000027622",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 91,
"experimental": 276,
"database": 0,
"textmining": 734,
"combined_score": 809
},
{
"protein2": "10116.ENSRNOP00000014320",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 51,
"experimental": 62,
"database": 0,
"textmining": 957,
"combined_score": 958
},
{
"protein2": "10116.ENSRNOP00000068620",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 52,
"experimental": 0,
"database": 500,
"textmining": 687,
"combined_score": 838
},
{
"protein2": "10116.ENSRNOP00000006453",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 72,
"experimental": 100,
"database": 500,
"textmining": 549,
"combined_score": 786
},
{
"protein2": "10116.ENSRNOP00000017305",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 0,
"textmining": 726,
"combined_score": 726
},
{
"protein2": "10116.ENSRNOP00000052059",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 58,
"experimental": 276,
"database": 0,
"textmining": 745,
"combined_score": 811
},
{
"protein2": "10116.ENSRNOP00000046455",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 74,
"experimental": 360,
"database": 500,
"textmining": 195,
"combined_score": 729
},
{
"protein2": "10116.ENSRNOP00000069434",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 63,
"experimental": 0,
"database": 0,
"textmining": 718,
"combined_score": 724
},
{
"protein2": "10116.ENSRNOP00000000617",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 56,
"experimental": 360,
"database": 500,
"textmining": 291,
"combined_score": 757
},
{
"protein2": "10116.ENSRNOP00000072988",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 64,
"experimental": 0,
"database": 0,
"textmining": 790,
"combined_score": 794
},
{
"protein2": "10116.ENSRNOP00000015109",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 44,
"experimental": 100,
"database": 500,
"textmining": 689,
"combined_score": 848
},
{
"protein2": "10116.ENSRNOP00000073308",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 75,
"experimental": 99,
"database": 500,
"textmining": 670,
"combined_score": 843
},
{
"protein2": "10116.ENSRNOP00000001659",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 46,
"experimental": 770,
"database": 0,
"textmining": 331,
"combined_score": 840
},
{
"protein2": "10116.ENSRNOP00000074299",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 64,
"database": 0,
"textmining": 803,
"combined_score": 808
},
{
"protein2": "10116.ENSRNOP00000001893",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 45,
"database": 0,
"textmining": 870,
"combined_score": 870
},
{
"protein2": "10116.ENSRNOP00000006523",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 78,
"experimental": 99,
"database": 500,
"textmining": 459,
"combined_score": 745
},
{
"protein2": "10116.ENSRNOP00000028155",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 598,
"database": 0,
"textmining": 892,
"combined_score": 954
}
] |
A0A0B4J1F4
|
Arrestin domain-containing protein 4
|
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:27462458). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (By similarity). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). May play a role in glucose uptake (By similarity). Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 (By similarity). {ECO:0000250|UniProtKB:Q8NCT1, ECO:0000269|PubMed:27462458}.
|
Mus musculus (Mouse)
| 415 |
Early endosome {ECO:0000269|PubMed:19605364}. Cell membrane {ECO:0000269|PubMed:19605364, ECO:0000269|PubMed:27462458}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:19605364}. Note=Also found in extracellular vesicles different from exosomes. {ECO:0000269|PubMed:27462458}.
|
MGGEAGADGPRGRVKSLGLVFEDESKGCYSSGETVAGHVLLEAAEPVALRGLRLEAQGRATSAWGPSAGARVCIGGGSPAASSEVEYLNLRLSLLEAPAGEGVTLLQPGKHEFPFRFQLPSEPLATSFTGKYGSIQYCVRAVLERPQVPDQSVRRELQVVSHVDVNTPPLLTPMLKTQEKMVGCWLFTSGPVSLSVKIERKGYCNGEAIPIYAEIENCSSRLVVPKAAIFQTQTYLASGKTKTVRHMVANVRGNHIGSGSTDTWNGKMLKIPPVTPSILDCCIIRVDYSLAVYIHIPGAKRLMLELPLVIGTIPYSGFGRRNSSVASQFSMDMCWLALALPEQPEAPPNYADVVSEEEFSRHVPPYPQPSDCDGEACYSMFACIQEFRFQPPPLYSEVDPHPGDAQETQPVSFIL
|
[
"GO:0008152",
"GO:0051234",
"GO:0036211",
"GO:0070727",
"GO:0051641",
"GO:0009987",
"GO:0071840",
"GO:0071702",
"GO:0051179",
"GO:0043412",
"GO:0032446",
"GO:0008150",
"GO:0070647",
"GO:1901564",
"GO:0019538",
"GO:0044085",
"GO:0071704",
"GO:0071705",
"GO:0006810",
"GO:0008104",
"GO:0140112",
"GO:0043170",
"GO:0016567",
"GO:0015031",
"GO:0045184",
"GO:0044238",
"GO:0033036",
"GO:0006807",
"GO:0065010",
"GO:0043226",
"GO:1903561",
"GO:0110165",
"GO:0031982",
"GO:0071944",
"GO:0005575",
"GO:0016020",
"GO:0043227",
"GO:0005886",
"GO:0043230",
"GO:0005576",
"GO:0030674",
"GO:0003674",
"GO:1990756",
"GO:0140767",
"GO:0060090"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0051179",
"GO:0051234",
"GO:0051641",
"GO:0071840",
"GO:0071704",
"GO:0044238",
"GO:0033036",
"GO:0006807",
"GO:0070727",
"GO:1901564",
"GO:0019538",
"GO:0044085",
"GO:0006810",
"GO:0043170",
"GO:0045184",
"GO:0036211",
"GO:0071702",
"GO:0043412",
"GO:0071705",
"GO:0008104",
"GO:0140112",
"GO:0015031",
"GO:0070647",
"GO:0032446",
"GO:0016567"
] |
[
"GO:0003674",
"GO:0060090",
"GO:0030674",
"GO:0140767",
"GO:1990756"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0043226",
"GO:0071944",
"GO:0016020",
"GO:0005576",
"GO:0043227",
"GO:0005886",
"GO:0043230",
"GO:0065010",
"GO:0031982",
"GO:1903561"
] |
[
"IPR014752",
"IPR011021",
"IPR011022",
"IPR050357",
"IPR014756"
] |
af_db/AF-A0A0B4J1F4-F1-model_v4.cif.gz
|
10090.ENSMUSP00000044578
|
[
"10090.ENSMUSP00000034740"
] |
[
{
"protein2": "10090.ENSMUSP00000034740",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 548,
"database": 0,
"textmining": 412,
"combined_score": 722
}
] |
A0A0B4K7J2
|
E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358)
|
E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope (PubMed:17682050). Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway (PubMed:17682050, PubMed:27979731). Plays a role in nuclear mRNA export by recruiting the mRNA transport complex composed of Nxt1 and sbr/Nxf1 to the NPC (PubMed:14729961). Essential during germline development for transposon silencing and piRNA biogenesis probably by regulating piwi localization to the nucleus (PubMed:29735528). During oogenesis, required to form granules that modulate the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769). {ECO:0000250|UniProtKB:P49792, ECO:0000269|PubMed:14729961, ECO:0000269|PubMed:17682050, ECO:0000269|PubMed:20547758, ECO:0000269|PubMed:27979731, ECO:0000269|PubMed:29735528, ECO:0000269|PubMed:31626769}.
|
Drosophila melanogaster (Fruit fly)
| 2,718 |
Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P49792}. Note=Localizes to annulate lamellae, stacked membrane sheets of the endoplasmic reticulum. Localizes to granules which travel from nurse cells into the ooplasm through ring canals connecting the cytoplasm of the two cell types. {ECO:0000269|PubMed:31626769}.
|
MFTTRKEVDAHVHKMLGKLQPGRERDIKGLAVARLYMKVQEYPKAIEYLNGYLRVRDDAVGHNMIATCYSRLNPPDVTEALQHYQRSIQIDPRQSEVVIDACELLVKENNASITECARYWLDQANSLDLSGNKQVFNLRMRVNLADSNGERDDTSGGDGEQNTLEILMYKELQARPQDVNIRIQLLRSYVEKMKIDQAFNYALKTELESKNCTSQSNEWYEQIWMVLFKIEMAKDVKKNWRFWHFALHTLDRLVQLSLEGSGLADSSKQLFRLDQYLFKFSTSIERSGDAPQRDLHQACIDHFTGQLLLHAVTLIFKREVLANKNKWMSTLRSALPLLLLGYQVRPIDDSSTNQWIKHCDAEQKQLIQMWRPQGAFRCAQLGRTLLGCLDRSQMEIKNDRENAEFDENKNSGNSMPGLFADSEELLASAHQQCLDKSWRSQIYQQLFTHAEHKLKDTSSHLVRNLRLQLPLFEWPNLAHIENYELQALVLPPHSLAQHVYLALGTDPNKLGDAPRVVFYEGFQRDVKQNLNYCGQDSISQVDVDLYLYATTIQTRRKLQIQREVYDSSNLGNRNAAARPHMMPFANLVGQLGAPEQSNWWDLVVRLNSNQLITEGNRAEQRAQLQHGLEAVRGVNGPKADAIIIFQLGKILNSRSDRSSLEARIDTLYRQGFSILRHQHNQQMESYVRVFKYGSAGSTAAWQDLQSLAEEAVTYFSEKMFRIGQYEQFLDEVRGLHLPMAYFLQSEACHHLEESSKLPRTSRDRYSERRRECLQKTQKLIKNDDKHPLIAAMHRHQQDRNSRGIDNSFGSPDVHNNSSAYEDAEDDFYSHAAFSANRSRRQLEVTPVTPIVMAQPSQEMEQAVKQISKSLCVLKDDVSVGMEAMRQDIKVLTEKFTGLEDLLKKIKISSRDTPTRDVDPAAALGLDDLFIIEDALAEHQQQQQHQQQQSHNQGAIHPVVPNPYTSGFYNGMPNTPSAQERFLQGPYGSPMFNQNQMYNYYAAQAQAQAQAQFLRTPPAPGSIPPPNMFGPRNPNFGLPSMFPPPTVPSVAPYIDAMGNFTQPPPSLIPPPAQPAAPPAPLNILESKPVVALPTPGFFNTTTPVFGASPIQVPQSKPLTVPTVPIPSTAPAPPIAGTVNPPATTAVPPPVHIPQVAPSVPAQPPAPAPVSVPSMFNRALNNQPVEKEPPANVVITSSDPLPKPTTASVQPTLSVTIPAQHIKPSLVQAPEQPAQSAQPAQPSVSGVGSLSFNFGSKSSESPFSFKTQVAKAAAEKQKEQEEAEQNQSGATDPNKTLPQDTSADDYDPRPDFKPIIPLPDEVEVRTGEEGEDIKFTSRAKLFRYVDKEWKERGTGVIKILCDKATGVSRVLMRRDQTHKVCANHTITADITINVANQDKDKKSLLWAANDFADEQVTLERFLVRFKTGELAEEFRVAFTKASEAAKSKETVKPTVNTAEKGSTATAPAAFKSFVTSTPAANSLINKPQEQTKTQPNPDPPATAAKSLFGTLSVSAAPATSAPASATPFASFSFTPNGSSGFGTSTASPFGNLSFGTASAVGSGNNTTLFTTALIKDNTVQGKTLQQESQLNKSNSSDAEEEYVPTAQFVPVIALPDIVEVVTGEENEDVLFEHRAKLLRWDKEANEWKERGLGNMKLLRDRTDPNKVRLLMRREQVHKLCCNQRLLPETKFTYATNCKAAVTWGAQDYSDEELTTALLAVRFKSQDICQQFLEAVQKAQQSIGNEPKKEEVPSAAGEKEKPIKGFGDAFKPKAGSWNCQACYTNNGQDQLYCLACQEPKDATVPPKQSGLDQGNALNLTTSSSNKFSFGFASSATLPATGGFSFGGATQPKEKPAVAVVTASASAPTSVQTAALGFGKSSMTSGFGDAFKPAVGSWSCSACYVNNPGESLYCSACDAPKNDTVPQKEKSLGSGLNLPPTSKFSFGFGAAAAGDKDQAGDGATFNFAAMPAAVAPTTSIGSSSFTFSMTKPKPDQQQPNSTAAKEDEDNDSQEVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAKLYRLNESDWKERGLGDVKILRHRQTKKLRVVMRREQVFKICLNHVLNENVVYREKTETSWMFAVHDFSEGESVLERFTLRFKNKEVAQGFMEAIKNALNETAKPIEDSPVVGSVSQSTEANKPSQKNDGAAKSRGGESEVLDVGKTSSVRPTTHEVIPPLPMTLPLLTLPQPLAKPNDYQTPATILFKGSSLSRNNSSASEASKTPSSAFIFGSTDKSEPGKDAGPLANLQKLASGEGQGNVLGSIFRSGSSNENSSDGSVKFFFGGGNKAAEQQKKDSSESVFGGNKADSQSPATQEAPKLAFGGIAAPVFGDANPFGGHKVNLQKSDGKEEPKSIIGGTPLLFGGSNAFGIPKIETQSPAKDFVFGSAPAFGQMATFSFTAAKNEKEKDITSNNTTDLKAEGKEKKELVPETTSTFADLAKTGSTFADLASNPGGTFADLANKTGNDFANLSANSQGTTVGFNKSAGGGFYNLTHQNAFKNFESPQATEECDDDGDATTDDNYDPHYDAIVELPDEIVVTTGEENETKLFGERAKLYRYDAESKQWKERGVGEIKVLEHPELQTFRLIMRQEQIHKLVLNMNISASLQMDYMNAQMKSFLWAGYNYAVDAEGKVDTEGVLERLACRFAKEEIASEFLNTVNSCIKRAKALQGDEENKNDDAPEEQASS
|
[
"GO:0006606",
"GO:0008152",
"GO:0032241",
"GO:0019953",
"GO:0006913",
"GO:0007276",
"GO:0032239",
"GO:0051641",
"GO:0048869",
"GO:0007281",
"GO:0048856",
"GO:0034504",
"GO:0051179",
"GO:0007275",
"GO:0051170",
"GO:0033365",
"GO:1903829",
"GO:0007419",
"GO:0048518",
"GO:0051049",
"GO:0016070",
"GO:0042221",
"GO:0071705",
"GO:0044085",
"GO:0034470",
"GO:0032388",
"GO:0010604",
"GO:0050789",
"GO:0010528",
"GO:0048468",
"GO:0019222",
"GO:0071310",
"GO:0030154",
"GO:0046931",
"GO:0070918",
"GO:0046483",
"GO:0072594",
"GO:0051292",
"GO:0032879",
"GO:0060341",
"GO:0048731",
"GO:0048513",
"GO:0006807",
"GO:0022414",
"GO:0051234",
"GO:0065003",
"GO:0035626",
"GO:0051649",
"GO:0071495",
"GO:0060255",
"GO:0046824",
"GO:0023052",
"GO:0071840",
"GO:0071702",
"GO:0010628",
"GO:0051169",
"GO:0006725",
"GO:0030522",
"GO:0034641",
"GO:0032880",
"GO:0006607",
"GO:0071704",
"GO:0032504",
"GO:0031047",
"GO:0003006",
"GO:0043170",
"GO:0010033",
"GO:0051050",
"GO:0009725",
"GO:0006396",
"GO:0000003",
"GO:0045184",
"GO:0032501",
"GO:0010468",
"GO:0033036",
"GO:0009892",
"GO:0046822",
"GO:0022607",
"GO:0065007",
"GO:0006886",
"GO:0032870",
"GO:0044237",
"GO:1901360",
"GO:0008150",
"GO:0042127",
"GO:0006997",
"GO:0007399",
"GO:0046907",
"GO:0022412",
"GO:0050896",
"GO:0009755",
"GO:0048522",
"GO:0006139",
"GO:0090304",
"GO:0015031",
"GO:0070887",
"GO:0010605",
"GO:0009719",
"GO:0006810",
"GO:0050794",
"GO:0034587",
"GO:0009893",
"GO:0051716",
"GO:0046833",
"GO:0070727",
"GO:0032502",
"GO:0009987",
"GO:0016043",
"GO:0007417",
"GO:1900182",
"GO:0043933",
"GO:0008104",
"GO:1900180",
"GO:0046831",
"GO:0006996",
"GO:0048609",
"GO:0048519",
"GO:0010467",
"GO:0010629",
"GO:0007154",
"GO:0007165",
"GO:0044238",
"GO:0008284",
"GO:0034660",
"GO:0006999",
"GO:0032386",
"GO:0042175",
"GO:0005575",
"GO:0005642",
"GO:0016020",
"GO:0012505",
"GO:0110165",
"GO:0005515",
"GO:0005488",
"GO:0003674"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0051179",
"GO:0048518",
"GO:0050789",
"GO:0022414",
"GO:0023052",
"GO:0000003",
"GO:0032501",
"GO:0065007",
"GO:0050896",
"GO:0032502",
"GO:0009987",
"GO:0048519",
"GO:0019953",
"GO:0051641",
"GO:0048869",
"GO:0048856",
"GO:0007275",
"GO:0042221",
"GO:0019222",
"GO:0032879",
"GO:0006807",
"GO:0051234",
"GO:0071840",
"GO:0071704",
"GO:0032504",
"GO:0003006",
"GO:0051050",
"GO:0033036",
"GO:0009892",
"GO:0044237",
"GO:0022412",
"GO:0048522",
"GO:0009719",
"GO:0050794",
"GO:0009893",
"GO:0051716",
"GO:0048609",
"GO:0007154",
"GO:0007165",
"GO:0044238",
"GO:0032241",
"GO:0007276",
"GO:0007281",
"GO:1903829",
"GO:0051049",
"GO:0044085",
"GO:0032388",
"GO:0010604",
"GO:0010528",
"GO:0048468",
"GO:0030154",
"GO:0046483",
"GO:0060341",
"GO:0048731",
"GO:0048513",
"GO:0051649",
"GO:0071495",
"GO:0060255",
"GO:0006725",
"GO:0030522",
"GO:0034641",
"GO:0043170",
"GO:0010033",
"GO:0009725",
"GO:0045184",
"GO:1901360",
"GO:0042127",
"GO:0046907",
"GO:0009755",
"GO:0006139",
"GO:0070887",
"GO:0010605",
"GO:0006810",
"GO:0070727",
"GO:0016043",
"GO:0008284",
"GO:0032239",
"GO:0007419",
"GO:0071705",
"GO:0071310",
"GO:0072594",
"GO:0035626",
"GO:0046824",
"GO:0071702",
"GO:0010628",
"GO:0051169",
"GO:0032880",
"GO:0010468",
"GO:0022607",
"GO:0006886",
"GO:0032870",
"GO:0007399",
"GO:0090304",
"GO:0015031",
"GO:0046833",
"GO:0007417",
"GO:1900182",
"GO:0043933",
"GO:0008104",
"GO:0006996",
"GO:0010467",
"GO:0010629",
"GO:0032386",
"GO:0006606",
"GO:0006913",
"GO:0033365",
"GO:0016070",
"GO:0065003",
"GO:0031047",
"GO:0006396",
"GO:0046822",
"GO:0006997",
"GO:1900180",
"GO:0046831",
"GO:0006999",
"GO:0034504",
"GO:0051170",
"GO:0034470",
"GO:0046931",
"GO:0070918",
"GO:0051292",
"GO:0006607",
"GO:0034660",
"GO:0034587"
] |
[
"GO:0003674",
"GO:0005488",
"GO:0005515"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0016020",
"GO:0012505",
"GO:0042175",
"GO:0005642"
] |
[
"IPR011993",
"IPR000156",
"IPR045255",
"IPR011990",
"IPR001876",
"IPR036443"
] | null |
7227.FBpp0293235
|
[
"7227.FBpp0082998",
"7227.FBpp0082137",
"7227.FBpp0082065",
"7227.FBpp0309200",
"7227.FBpp0083851",
"7227.FBpp0087063",
"7227.FBpp0076408",
"7227.FBpp0073659",
"7227.FBpp0076457",
"7227.FBpp0080775",
"7227.FBpp0079278",
"7227.FBpp0076708",
"7227.FBpp0301731",
"7227.FBpp0074567",
"7227.FBpp0311988",
"7227.FBpp0087775",
"7227.FBpp0304467",
"7227.FBpp0073267",
"7227.FBpp0309144",
"7227.FBpp0076711",
"7227.FBpp0072150",
"7227.FBpp0073328",
"7227.FBpp0081156",
"7227.FBpp0087861",
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"7227.FBpp0087937",
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"7227.FBpp0086294",
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"7227.FBpp0297623",
"7227.FBpp0071905",
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"7227.FBpp0078984",
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"7227.FBpp0074372",
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"7227.FBpp0081585",
"7227.FBpp0309478",
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"7227.FBpp0306614",
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"7227.FBpp0304737",
"7227.FBpp0294037",
"7227.FBpp0302819",
"7227.FBpp0071600",
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"7227.FBpp0075684",
"7227.FBpp0300958",
"7227.FBpp0308972",
"7227.FBpp0312096",
"7227.FBpp0083195",
"7227.FBpp0074515",
"7227.FBpp0079527",
"7227.FBpp0076777",
"7227.FBpp0085954"
] |
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}
] |
A0A0B4KEE4
|
Klaroid protein
|
Component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (By similarity). Is required to nuclear migration in eye and to anchor klar in the nuclear membrane (PubMed:18820457). {ECO:0000250|UniProtKB:O94901, ECO:0000269|PubMed:18820457}.
|
Drosophila melanogaster (Fruit fly)
| 965 |
Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:32066907}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18820457, ECO:0000269|PubMed:32066907}. Note=Lam is required for perinuclear localization of Koi (PubMed:18820457). In the fat body, localizes to a perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs) (PubMed:32066907). {ECO:0000269|PubMed:18820457, ECO:0000269|PubMed:32066907}.
|
MSENTYQIETRRRSRSKTPFLRSSCDHENCEHAGEEGHVHHLKRKSAAPNVQTIIEEHIVESSISKKTRAKAFAQLTSDYSSDDMTPDAKRKQNSITATVTSILTKRSGGATSTPRNRSQLETTQNTLNSAQEKLNQSNGNLSSGNVSDYLAYIEYRDAGEYWNKTPKTDYTYSELSPHRRQLAPGIVAMPNMSRKSLENHNDRVNYMVQQNPAQEEFIRRRYQSKYTQQVNYDSADELDATFGQQKQSWWLIRLIQLVVSSITTVWSRVTNLSATETTAYQNYHAKRQQSQQVGLWWKIVQTIGGGLASLLRYLYVFIGSVLSLDTWLLRSSDAENKSKKRFLIFLLILLPLLLLSGWLLLQEDQRSAYVQRAEALLPLPLSIFGSLRSRFSNAGATLKSWMEVPTVRSPQREAEAIKVNMASIEQNIQKALTAEEYENILNHVNSYVQQLVELKMQQHSKELAPQQIELFVKLMKENLKQIMYKTELSEKDLSDLAIKLKLELQSSGGWQDGAKLSQANLEEITKLIKAEVHLHESHYTIQLDRIDFASLLERILAAPALADFVDARISLRVGELEPKESSGSSDAEVQIERLNREIAFIKLALSDKQAENADLHQSISNLKLGQEDLLERIQQHELSQDRRFHGLLAEIENKLSALNDSQFALLNKQIKLSLVEILGFKQSTAGGSAGQLDDFDLQTWVRSMFVAKDYLEQQLLELNKRTNNNIRDEIERSSILLMSDISQRLKREILLVVEAKHNESTKALKGHIREEEVRQIVKTVLAIYDADKTGLVDFALESAGGQILSTRCTESYQTKSAQISVFGIPLWYPTNTPRVAISPNVQPGECWAFQGFPGFLVLKLNSLVYVTGFTLEHIPKSLSPTGRIESAPRNFTVWGLEQEKDQEPVLFGDYQFEDNGASLQYFAVQNLDIKRPYEIVELRIETNHGHPTYTCLYRFRVHGKPPAT
|
[
"GO:0008152",
"GO:0051641",
"GO:0051179",
"GO:0044237",
"GO:1901360",
"GO:0000724",
"GO:0008150",
"GO:0046907",
"GO:0006139",
"GO:0050896",
"GO:0090304",
"GO:0006974",
"GO:0051656",
"GO:0000725",
"GO:0046483",
"GO:0033554",
"GO:0006810",
"GO:0006807",
"GO:0051234",
"GO:0051716",
"GO:0051649",
"GO:0009987",
"GO:0007097",
"GO:0006259",
"GO:0044238",
"GO:0006725",
"GO:0006950",
"GO:0034641",
"GO:0071704",
"GO:0006310",
"GO:0044260",
"GO:0043170",
"GO:0006281",
"GO:0051640",
"GO:0051647",
"GO:0006302",
"GO:0005622",
"GO:0031981",
"GO:0031967",
"GO:0043226",
"GO:0043233",
"GO:0031975",
"GO:0005575",
"GO:0005635",
"GO:0031974",
"GO:0043231",
"GO:0043229",
"GO:0110165",
"GO:0070013",
"GO:0034399",
"GO:0048471",
"GO:0005737",
"GO:0043227",
"GO:0012505",
"GO:0005634"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0051179",
"GO:0050896",
"GO:0009987",
"GO:0051641",
"GO:0044237",
"GO:0006807",
"GO:0051234",
"GO:0051716",
"GO:0044238",
"GO:0006950",
"GO:0071704",
"GO:0051640",
"GO:1901360",
"GO:0046907",
"GO:0006139",
"GO:0051656",
"GO:0046483",
"GO:0033554",
"GO:0006810",
"GO:0051649",
"GO:0006725",
"GO:0034641",
"GO:0044260",
"GO:0043170",
"GO:0051647",
"GO:0090304",
"GO:0006974",
"GO:0007097",
"GO:0006259",
"GO:0006310",
"GO:0006281",
"GO:0000725",
"GO:0006302",
"GO:0000724"
] | null |
[
"GO:0005575",
"GO:0110165",
"GO:0005622",
"GO:0043226",
"GO:0031975",
"GO:0031974",
"GO:0034399",
"GO:0048471",
"GO:0005737",
"GO:0012505",
"GO:0031967",
"GO:0043233",
"GO:0005635",
"GO:0043229",
"GO:0043227",
"GO:0043231",
"GO:0070013",
"GO:0031981",
"GO:0005634"
] |
[
"IPR045119",
"IPR012919"
] |
af_db/AF-A0A0B4KEE4-F1-model_v4.cif.gz
|
7227.FBpp0307480
|
[
"7227.FBpp0292449"
] |
[
{
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"combined_score": 814
}
] |
A0A088MLT8
|
IQCJ-SCHIP1 readthrough transcript protein
|
May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943, PubMed:25953347, PubMed:27979964). May also play a role in axon outgrowth and guidance (PubMed:25953347). {ECO:0000269|PubMed:25950943, ECO:0000269|PubMed:25953347, ECO:0000269|PubMed:27979964}.
|
Mus musculus (Mouse)
| 559 |
Cell projection, axon {ECO:0000269|PubMed:18550753}. Cytoplasm {ECO:0000250|UniProtKB:B3KU38}. Note=Localizes to the axon initial segments (AIS) and nodes of Ranvier of neurons and is absent from dendrites. {ECO:0000269|PubMed:18550753}.
|
MRLEELKRLQNPLEQVDDGKYLLENHQLAMDVENNIENYPLSLQPLESKVKIIQRAWREYLQRQDPLEKRSPSPPSVSSDKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDDRGYRDDGCPAREPGDVSARIGSSGSGSRSAATTMPSPMPNGNLHPHDPQDLRHNGNVVVAGRPNASRVPRRPIQKTQPPGSRRGGRNRASGGLCLQPPDGGTRVPEEPPAPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSARLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK
|
[
"GO:0032502",
"GO:0009987",
"GO:0048856",
"GO:0007399",
"GO:0007275",
"GO:0032501",
"GO:0048731",
"GO:0007272",
"GO:0008150",
"GO:0008366",
"GO:0043005",
"GO:0110165",
"GO:0044304",
"GO:0030424",
"GO:0033268",
"GO:0042995",
"GO:0005575",
"GO:0120025",
"GO:0043194",
"GO:0005488",
"GO:0030506",
"GO:0044325",
"GO:0003674",
"GO:0005516",
"GO:0008092",
"GO:0005515"
] |
[
"GO:0008150",
"GO:0032502",
"GO:0009987",
"GO:0032501",
"GO:0048856",
"GO:0007275",
"GO:0007272",
"GO:0048731",
"GO:0008366",
"GO:0007399"
] |
[
"GO:0003674",
"GO:0005488",
"GO:0005515",
"GO:0044325",
"GO:0005516",
"GO:0008092",
"GO:0030506"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0044304",
"GO:0033268",
"GO:0042995",
"GO:0043194",
"GO:0120025",
"GO:0043005",
"GO:0030424"
] |
[
"IPR029362",
"IPR039045",
"IPR015649"
] |
af_db/AF-A0A088MLT8-F1-model_v4.cif.gz
|
10090.ENSMUSP00000138212
|
[
"10090.ENSMUSP00000112963"
] |
[
{
"protein2": "10090.ENSMUSP00000112963",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 59,
"database": 0,
"textmining": 761,
"combined_score": 765
}
] |
A0A087WPF7
|
Autism susceptibility gene 2 protein homolog
|
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B. As a consequence, the complex mediates transcriptional activation (By similarity). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (PubMed:25533347). {ECO:0000250|UniProtKB:Q8WXX7, ECO:0000269|PubMed:25533347}.
|
Mus musculus (Mouse)
| 1,261 |
Nucleus {ECO:0000269|PubMed:19948250, ECO:0000269|PubMed:25519132, ECO:0000269|PubMed:25533347}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25533347}. Cell projection, growth cone {ECO:0000269|PubMed:25533347}. Note=Detected both in cytoplasm and nucleus (PubMed:25533347). Colocalizes with RAC1 at actin-rich growth cones (PubMed:25533347). Detected on the promoter region of actively transcribed genes (PubMed:25519132). {ECO:0000269|PubMed:25519132, ECO:0000269|PubMed:25533347}.
|
MDGPTRGHGLRKKRRSRSQRDRERRSRAGLGTGAAGGIGAGRTRAPSLASSSGSDKEDNGKPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEALEKDVAVKPQERAEKRQTPLTKKKREALTNGLSFHSKKSRLSHSHHYSSDRENDRNLCQHLGKRKKMPKGLRQLKPGQNSCRDSDSESASGESKGFQRSSSRERLSDSSAPSSLGTGYFCDSDSDQEEKASDASSEKLFNTVLVNKDPELGVGALPEHNQDAGPIVPKISGLERSQEKSQDCCKEPVFEPVVLKDPHPQLPQLPSQAQAEPQLQIPSPGPDLVPRTEAPPQFPPPSTQPAQGPPEAQLQPAPLPQVQQRPPRPQSPSHLLQQTLPPVQSHPSSQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVPGHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSVFGHKDSPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHPSHPSPAPPVPVSALGHNRSSTDPTTRGHLNTEAREKDKPKEKERDHSGSRKDLTTEEHKAKESHLPERDGHSHEGRAAGEEPKQLSRVPSPYVRTPGVDSTRPNSTSSREAEPRKGEPAYENPKKNAEVKVKEERKEDHDLPTEAPQAHRTSEAPPPSSSASASVHPGPLASMPMTVGVTGIHAMNSIGSLDRTRMVTPFMGLSPIPGGERFPYPSFHWDPMRDPLRDPYRDLDMHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLAVDPRREHERGGHLDERERLHVLREDYEHPRLHPVHPASLDGHLPHPSLLTPGLPSMHYPRISPTAGHQNGLLNKTPPTAALSAPPPLISTLGGRPGSPRRTTPLSAEIRERPPSHTLKDIEAR
|
[
"GO:0032989",
"GO:0009605",
"GO:0009967",
"GO:0048667",
"GO:0048589",
"GO:0048869",
"GO:0048856",
"GO:0023056",
"GO:0007275",
"GO:0120032",
"GO:0009653",
"GO:0048870",
"GO:0048518",
"GO:0030030",
"GO:0031344",
"GO:0050789",
"GO:0048468",
"GO:0060560",
"GO:0048584",
"GO:0030154",
"GO:0120035",
"GO:0046578",
"GO:0032990",
"GO:0048731",
"GO:0097484",
"GO:0048812",
"GO:0009966",
"GO:0031532",
"GO:0040007",
"GO:0071840",
"GO:0051130",
"GO:0120039",
"GO:0120036",
"GO:0061564",
"GO:0030036",
"GO:0044089",
"GO:0032501",
"GO:0060491",
"GO:0048666",
"GO:0044087",
"GO:0051057",
"GO:0060004",
"GO:0035020",
"GO:0007010",
"GO:0000902",
"GO:1902743",
"GO:0035022",
"GO:0022008",
"GO:0065007",
"GO:0048588",
"GO:0010591",
"GO:0000904",
"GO:0016049",
"GO:0008150",
"GO:0007399",
"GO:0001764",
"GO:0050896",
"GO:0031346",
"GO:0010646",
"GO:0060013",
"GO:1902745",
"GO:0031175",
"GO:0051056",
"GO:0050794",
"GO:0048699",
"GO:0048583",
"GO:0098582",
"GO:0032502",
"GO:0009987",
"GO:0016043",
"GO:0023051",
"GO:0010647",
"GO:0120034",
"GO:0010592",
"GO:1902533",
"GO:0030029",
"GO:0046579",
"GO:0048675",
"GO:0051128",
"GO:0006996",
"GO:0048858",
"GO:1990138",
"GO:0007409",
"GO:0030182",
"GO:1902531",
"GO:0007610",
"GO:0016477",
"GO:0071625",
"GO:0048522",
"GO:0005856",
"GO:0005622",
"GO:0043226",
"GO:0043005",
"GO:0150034",
"GO:0042995",
"GO:0005575",
"GO:0120025",
"GO:0043231",
"GO:0043229",
"GO:0030427",
"GO:0110165",
"GO:0030424",
"GO:0043232",
"GO:0030426",
"GO:0043227",
"GO:0015629",
"GO:0005634",
"GO:0043228",
"GO:0005515",
"GO:0005488",
"GO:0003674"
] |
[
"GO:0008150",
"GO:0048518",
"GO:0050789",
"GO:0040007",
"GO:0032501",
"GO:0065007",
"GO:0050896",
"GO:0032502",
"GO:0009987",
"GO:0009605",
"GO:0048589",
"GO:0048869",
"GO:0048856",
"GO:0023056",
"GO:0007275",
"GO:0009653",
"GO:0048870",
"GO:0048584",
"GO:0071840",
"GO:0016049",
"GO:0050794",
"GO:0048583",
"GO:0023051",
"GO:0030029",
"GO:0007610",
"GO:0048522",
"GO:0032989",
"GO:0009967",
"GO:0048468",
"GO:0060560",
"GO:0030154",
"GO:0048731",
"GO:0009966",
"GO:0051130",
"GO:0030036",
"GO:0044089",
"GO:0044087",
"GO:0060004",
"GO:0000902",
"GO:0048588",
"GO:0010646",
"GO:0016043",
"GO:0010647",
"GO:0051128",
"GO:0016477",
"GO:0071625",
"GO:0030030",
"GO:0031344",
"GO:0032990",
"GO:0031532",
"GO:0060491",
"GO:0048666",
"GO:0022008",
"GO:0000904",
"GO:0007399",
"GO:0001764",
"GO:0031346",
"GO:0060013",
"GO:0098582",
"GO:0120034",
"GO:1902533",
"GO:0006996",
"GO:0048858",
"GO:1990138",
"GO:0030182",
"GO:1902531",
"GO:0048667",
"GO:0120032",
"GO:0120035",
"GO:0097484",
"GO:0120039",
"GO:0120036",
"GO:0051057",
"GO:0007010",
"GO:1902745",
"GO:0031175",
"GO:0051056",
"GO:0048699",
"GO:0010592",
"GO:0048675",
"GO:0046578",
"GO:0048812",
"GO:0061564",
"GO:1902743",
"GO:0010591",
"GO:0046579",
"GO:0007409",
"GO:0035020",
"GO:0035022"
] |
[
"GO:0003674",
"GO:0005488",
"GO:0005515"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0005622",
"GO:0043226",
"GO:0150034",
"GO:0042995",
"GO:0030427",
"GO:0120025",
"GO:0043229",
"GO:0030426",
"GO:0043227",
"GO:0043228",
"GO:0043005",
"GO:0043231",
"GO:0043232",
"GO:0005856",
"GO:0030424",
"GO:0005634",
"GO:0015629"
] |
[
"IPR023246"
] |
af_db/AF-A0A087WPF7-F1-model_v4.cif.gz
|
10090.ENSMUSP00000139759
|
[
"10090.ENSMUSP00000098677",
"10090.ENSMUSP00000148404",
"10090.ENSMUSP00000025183",
"10090.ENSMUSP00000153206",
"10090.ENSMUSP00000096829",
"10090.ENSMUSP00000140896",
"10090.ENSMUSP00000041790",
"10090.ENSMUSP00000079179"
] |
[
{
"protein2": "10090.ENSMUSP00000098677",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 421,
"database": 500,
"textmining": 613,
"combined_score": 878
},
{
"protein2": "10090.ENSMUSP00000148404",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 266,
"database": 500,
"textmining": 693,
"combined_score": 877
},
{
"protein2": "10090.ENSMUSP00000025183",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 85,
"database": 500,
"textmining": 446,
"combined_score": 724
},
{
"protein2": "10090.ENSMUSP00000153206",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 108,
"database": 800,
"textmining": 824,
"combined_score": 965
},
{
"protein2": "10090.ENSMUSP00000096829",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 266,
"database": 500,
"textmining": 700,
"combined_score": 880
},
{
"protein2": "10090.ENSMUSP00000140896",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 324,
"database": 500,
"textmining": 454,
"combined_score": 799
},
{
"protein2": "10090.ENSMUSP00000041790",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 49,
"experimental": 108,
"database": 0,
"textmining": 758,
"combined_score": 776
},
{
"protein2": "10090.ENSMUSP00000079179",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 421,
"database": 500,
"textmining": 677,
"combined_score": 898
}
] |
A0A0B4K692
|
Neprilysin-2 (EC 3.4.24.11) [Cleaved into: Neprilysin-2, soluble form]
|
Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues (PubMed:15554877, PubMed:17157960). Functions in female fertility, embryogenesis and memory formation (PubMed:24395329, PubMed:27629706). Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates (PubMed:24395329). Also required for normal patterns of hatching due to its important role in early embryonic development (PubMed:24395329). Required in the dorsal paired medial neurons for the proper formation of middle-term memory (PubMed:27629706). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep3 and Nep4 in normal long-term memory formation (PubMed:27629706). {ECO:0000269|PubMed:15554877, ECO:0000269|PubMed:17157960, ECO:0000269|PubMed:24395329, ECO:0000269|PubMed:27629706}.
|
Drosophila melanogaster (Fruit fly)
| 774 |
Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:15554877, ECO:0000269|PubMed:17157960}. Note=A secreted form exists that is probably produced by proteolytic cleavage (Probable). In embryos, adult Malpighian tubules and testes, detected in the soluble fraction but is not detected in the membrane fraction (PubMed:15554877, PubMed:17157960). {ECO:0000269|PubMed:15554877, ECO:0000269|PubMed:17157960, ECO:0000305|PubMed:15554877, ECO:0000305|PubMed:17157960}.
|
MQTVIQNPNWWRRRNKLEKSLLVSLGIMFVVLATGFGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLALSREYLVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW
|
[
"GO:0008152",
"GO:0046692",
"GO:0019098",
"GO:0044706",
"GO:0008150",
"GO:1901564",
"GO:0019538",
"GO:0007320",
"GO:0071704",
"GO:0006508",
"GO:0032504",
"GO:0007620",
"GO:0007617",
"GO:0043170",
"GO:0048609",
"GO:0000003",
"GO:0032501",
"GO:0044238",
"GO:0007610",
"GO:0006807",
"GO:0044703",
"GO:0022414",
"GO:0110165",
"GO:0071944",
"GO:0005575",
"GO:0016020",
"GO:0005886",
"GO:0005576",
"GO:0005615",
"GO:0003824",
"GO:0004175",
"GO:0008233",
"GO:0008237",
"GO:0004222",
"GO:0003674",
"GO:0140096",
"GO:0016787"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0000003",
"GO:0032501",
"GO:0022414",
"GO:0019098",
"GO:0044706",
"GO:0071704",
"GO:0032504",
"GO:0048609",
"GO:0044238",
"GO:0007610",
"GO:0006807",
"GO:0044703",
"GO:0046692",
"GO:1901564",
"GO:0019538",
"GO:0007320",
"GO:0007617",
"GO:0043170",
"GO:0006508",
"GO:0007620"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0140096",
"GO:0016787",
"GO:0008233",
"GO:0004175",
"GO:0008237",
"GO:0004222"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0071944",
"GO:0016020",
"GO:0005576",
"GO:0005615",
"GO:0005886"
] |
[
"IPR024079",
"IPR000718",
"IPR018497",
"IPR042089",
"IPR008753"
] |
af_db/AF-A0A0B4K692-F1-model_v4.cif.gz
|
7227.FBpp0293663
|
[
"7227.FBpp0087745",
"7227.FBpp0080131",
"7227.FBpp0080130",
"7227.FBpp0271781",
"7227.FBpp0072325",
"7227.FBpp0310234"
] |
[
{
"protein2": "7227.FBpp0087745",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 0,
"textmining": 842,
"combined_score": 841
},
{
"protein2": "7227.FBpp0080131",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 0,
"textmining": 842,
"combined_score": 841
},
{
"protein2": "7227.FBpp0080130",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 77,
"experimental": 0,
"database": 0,
"textmining": 842,
"combined_score": 848
},
{
"protein2": "7227.FBpp0271781",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 0,
"textmining": 922,
"combined_score": 921
},
{
"protein2": "7227.FBpp0072325",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 0,
"textmining": 842,
"combined_score": 841
},
{
"protein2": "7227.FBpp0310234",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 0,
"textmining": 847,
"combined_score": 847
}
] |
A0A061ACU2
|
Piezo-type mechanosensitive ion channel component 1
|
Pore-forming subunit of a mechanosensitive non-specific cation channel (By similarity). Generates currents characterized by a linear current-voltage relationship (By similarity). Plays a role in reproduction by positively regulating inter-tissue signaling to promote oocyte maturation, ovulation and fertilization, and sperm navigation from and to the spermatheca (PubMed:32490809). May play a role in regulating cytosolic and endoplasmic reticulum calcium ion release (PubMed:32490809). {ECO:0000250|UniProtKB:Q92508, ECO:0000269|PubMed:32490809}.
|
Caenorhabditis elegans
| 2,442 |
Cell membrane {ECO:0000269|PubMed:32490809}; Multi-pass membrane protein {ECO:0000255}.
|
MTVPPLLKSCVVKLLLPAALLAAAIIRPSFLSIGYVLLALVSAVLPPIRKSLALPKLVGTFVIITFLFCLAVALGVGSYQISEQVVHKNDRTYICNRSDTTLFRSIGLVRFHPTGTFESTRAFLPEIIATSAALLTIIIVMFLSHRDEQLDVVGDVVTVRSESGREQRRQRKLAAIMWSAIGNSLRRLTNFVLFLFTAYVGIVKPSLSNSIYFLAFLFISTWWSTYTPLRHGVYNQIKKFLIFYSALHFLVLYTYQIPIVHHSWLPTGSFLPRLFGLTVLMDSSCPEWWKFPFVAPDFNDDDLIMKWPLYANPIVVLVFFYLTVAQYKFTRNGSREYIDDNEYGSSVHEERFVSAGTVETNVDDVGQLISISESTASAPSGRGRGNTLLLSNASSSANDDEQGRARSRSPLRNGEEQGSIPLRKVTSQVVDRNKLSNIFNTTAPGDKESAASKGMIAVMTFVIFHSYSIALTAMMTWALLYHSIFGLILLILTCILWIFRDTRKSSFAMAPIILMYIEFLLILQYFLSMDIHAEIGDPAWMNFVGIEWTTLPVHAVIILCVQTLLTLPVFLLLRLARREKFYESLSDYERQRRINSYGTFGASKTGAGGVAVAKFQDPKSRKFAAFVEYLSNKVSVYFIFVVSVVLLVVSTCFAPNFYNILFFALWALNLIYLKFSFRLYRGLAYAFWLTLTFYTSIVIIALYIYQFPGVSQWIIRNTSLSQEWLNAIGLVDFRAIGESGALFLQLLAPIALFVVTMLQLKFFHGPWSRATSPRRAENDPPTSTTEAAAVASTSGTQGRAHAAGDTLVKKLHKLANQTIELLWRFFEVHISKIVFVIIAIFIANNINALYIPLVILLSLAICLPSAADGIFSLFMCAYLFLVALSKMIYQLDIVPELSQIDRGVGADNCSHGNISMPEWFGLKKEVEGTEPIYMLFGVIVSIIALAFQSIVIYRQRHYRASLGLPESMRAKVFPDFHHSHFDRSLKNAIQFLIDYGFYKFGLEITMIAIGIDIFNRMDALAAIQCFWLVLFALNKRVFVRRIWVFYVIYMAILYPLQFFSYVGLPPDSCIEYPWSYWIPSYSDDARFNLSYLLNLSIYGVNWPSAYLIGDFFVLLLASCQLAVFRREGEDNDSIYNDGNFVIKPENPQYDFIDTKKSYVDYFKSFVFHYGHWITLMSTLAAGIAGTSLFALGYIIFTLTMLWSGNNLYVMNSTLRSFEHTLKRWNALLGYTLFTITMKVCLQIFGCVFLSWFDQSGGWGKTLCIVRQLFSITCVNNECHVLKELEDFSKACAVETKEGNIGFDVIALSFLVFQIRIFHSWYFQHCMVEYRSEVILANRGAVLKNQLIEKEMKEQNEQQKAKFNDIRRRTEAIRERYQKQIERGAAERDFEPVTYGHAKRAGDYYMFKYDPENDDLVEPVDSFVPEVDPKATAYDRLDPGQIMYAATAHDLDLAKTVQQVKKGDTIKDPDSRALIAVSEPEARKPGGTEETDGDEDEDNKDSKVESTAKFIQKMIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKSGHSESLSNTSRKLTDIRSAVDLPSLQLVQSANDVEKMETAVSVDWQQKSSATRLLNAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFGEGGSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDKLSRNTSVNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGDPGHPILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPRINTTGMEKSDEARAWFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKGGVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSKKKQE
|
[
"GO:0001539",
"GO:0007018",
"GO:0009987",
"GO:0060278",
"GO:0065007",
"GO:2000243",
"GO:0097722",
"GO:0044706",
"GO:0060378",
"GO:0051239",
"GO:0048870",
"GO:0048518",
"GO:0008150",
"GO:0060279",
"GO:0030317",
"GO:0032504",
"GO:0007017",
"GO:2000241",
"GO:0003341",
"GO:0050789",
"GO:0060294",
"GO:0048609",
"GO:0090727",
"GO:0060285",
"GO:0000003",
"GO:0051240",
"GO:0032501",
"GO:0022414",
"GO:0071944",
"GO:0005575",
"GO:0110165",
"GO:0016020",
"GO:0005886"
] |
[
"GO:0008150",
"GO:0009987",
"GO:0065007",
"GO:0048518",
"GO:0050789",
"GO:0000003",
"GO:0032501",
"GO:0022414",
"GO:2000243",
"GO:0097722",
"GO:0044706",
"GO:0060378",
"GO:0051239",
"GO:0048870",
"GO:0032504",
"GO:0007017",
"GO:2000241",
"GO:0048609",
"GO:0051240",
"GO:0001539",
"GO:0007018",
"GO:0060278",
"GO:0060279",
"GO:0030317",
"GO:0090727",
"GO:0003341",
"GO:0060285",
"GO:0060294"
] | null |
[
"GO:0005575",
"GO:0110165",
"GO:0071944",
"GO:0016020",
"GO:0005886"
] |
[
"IPR027272",
"IPR031334",
"IPR031805"
] |
pdb_files/4PKE.pdb.gz
|
6239.C10C5.1g.1
|
[
"6239.T06E4.3a.1",
"6239.F58G11.3a.1",
"6239.F32A11.2.2",
"6239.Y39G10AR.14a.2",
"6239.Y92H12BR.3a.1",
"6239.Y41C4A.14.1",
"6239.C30E1.4.1",
"6239.F26D2.12a.1",
"6239.F33H2.5.1",
"6239.T05F1.6.1",
"6239.T05B4.6.1",
"6239.F40D4.11.1",
"6239.Y17G7B.5a.1",
"6239.F17A2.7.1",
"6239.F34D10.2.1",
"6239.F34D10.9.2",
"6239.F13C5.3a.1",
"6239.Y39A1A.23a.1",
"6239.T01G5.4.1",
"6239.C06B3.10.1",
"6239.Y60A3A.12.1",
"6239.F23C8.9.1",
"6239.Y79H2A.6b.1",
"6239.T20B12.5.1",
"6239.ZK380.4.1",
"6239.F47G9.2.1",
"6239.F17C11.10.2",
"6239.T13G4.2.1",
"6239.Y75B8A.22.1",
"6239.F25D1.4.1",
"6239.T08D2.7.1"
] |
[
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"database": 0,
"textmining": 668,
"combined_score": 913
},
{
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"coexpression": 764,
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"combined_score": 767
},
{
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"experimental": 609,
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"combined_score": 768
},
{
"protein2": "6239.Y39G10AR.14a.2",
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"coexpression": 435,
"experimental": 851,
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"combined_score": 918
},
{
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"combined_score": 737
},
{
"protein2": "6239.Y41C4A.14.1",
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"combined_score": 725
},
{
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},
{
"protein2": "6239.F26D2.12a.1",
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},
{
"protein2": "6239.F33H2.5.1",
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"combined_score": 722
},
{
"protein2": "6239.T05F1.6.1",
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},
{
"protein2": "6239.T05B4.6.1",
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},
{
"protein2": "6239.F40D4.11.1",
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"combined_score": 720
},
{
"protein2": "6239.Y17G7B.5a.1",
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"coexpression": 185,
"experimental": 701,
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"textmining": 567,
"combined_score": 885
},
{
"protein2": "6239.F17A2.7.1",
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},
{
"protein2": "6239.F34D10.2.1",
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"experimental": 525,
"database": 0,
"textmining": 410,
"combined_score": 707
},
{
"protein2": "6239.F34D10.9.2",
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"experimental": 525,
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"combined_score": 707
},
{
"protein2": "6239.F13C5.3a.1",
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},
{
"protein2": "6239.Y39A1A.23a.1",
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"coexpression": 0,
"experimental": 469,
"database": 0,
"textmining": 515,
"combined_score": 731
},
{
"protein2": "6239.T01G5.4.1",
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"coexpression": 846,
"experimental": 81,
"database": 0,
"textmining": 0,
"combined_score": 852
},
{
"protein2": "6239.C06B3.10.1",
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},
{
"protein2": "6239.Y60A3A.12.1",
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"coexpression": 76,
"experimental": 758,
"database": 0,
"textmining": 409,
"combined_score": 856
},
{
"protein2": "6239.F23C8.9.1",
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"fusion": 0,
"cooccurence": 0,
"coexpression": 349,
"experimental": 862,
"database": 0,
"textmining": 671,
"combined_score": 967
},
{
"protein2": "6239.Y79H2A.6b.1",
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"coexpression": 846,
"experimental": 0,
"database": 0,
"textmining": 0,
"combined_score": 846
},
{
"protein2": "6239.T20B12.5.1",
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"fusion": 0,
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"coexpression": 764,
"experimental": 0,
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},
{
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"experimental": 0,
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},
{
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},
{
"protein2": "6239.F17C11.10.2",
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"experimental": 634,
"database": 0,
"textmining": 575,
"combined_score": 932
},
{
"protein2": "6239.T13G4.2.1",
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"experimental": 0,
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},
{
"protein2": "6239.Y75B8A.22.1",
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"database": 0,
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},
{
"protein2": "6239.F25D1.4.1",
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"combined_score": 716
},
{
"protein2": "6239.T08D2.7.1",
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"experimental": 758,
"database": 0,
"textmining": 409,
"combined_score": 851
}
] |
A0A023I7E1
|
Glucan endo-1,3-beta-D-glucosidase 1 (Endo-1,3-beta-glucanase 1) (EC 3.2.1.39) (Laminarinase) (RmLam81A)
|
Cleaves internal linkages in 1,3-beta-glucan. {ECO:0000269|PubMed:34801773}.
|
Rhizomucor miehei
| 796 |
Secreted, cell wall {ECO:0000250|UniProtKB:P53753}.
|
MRFQVIVAAATITMITSYIPGVASQSTSDGDDLFVPVSNFDPKSIFPEIKHPFEPMYANTENGKIVPTNSWISNLFYPSADNLAPTTPDPYTLRLLDGYGGNPGLTIRQPSAKVLGSYPPTNDVPYTDAGYMINSVVVDLRLTSSEWSDVVPDRQVTDWDHLSANLRLSTPQDSNSYIDFPIVRGMAYITANYNNLTPQFLSQHAIISVEADEKKSDDNTSTFSGRKFKITMNDDPTSTFIIYSLGDKPLELRKQDNSNLVASKPYTGVIRVAKLPAPEFETLLDASRAVWPTGGDISARSDDNNGASYTIKWKTNSNEAPLLTYAYAHHLTSIDDSNVKRTDMTLQSATKGPMTALVGNEWTLRETELSPVEWLPLQAAPNPTTINEIMTEINKDIASNYTQETAKEDNYFSGKGLQKFAMLALILNKSDQTQLRNPELAQIALDKLKAAFLPYLQNEQADPFRYDTLYKGIVAKAGLPTSMGGTDDLSAEFGHSYYSDHHYHQGYFVVTAAIIHHLDPTWNADRLKAWTEALIRDVNNANDGDEYFAAFRNWDWFAGHSWAGGIKPDGALDGRDQESVPESVNFYWGAKLWGLATGNTPLTKLASLQLAVTKRTTYEYFWMLDGNKNRPENIVRNKVIGIYFEQKTDYTTYFGRFLEYIHGIQQLPMTPELMEYIRTPEFVSQEWDEKLGAIAPTVQSPWAGVLYLNYAIINPAEAYPALRKVQMDDGQTRSYSLYLTATRPHFFRRSLLAALARHGSTRRPSLPSSGDDDKHEDGFLLRFRRLNPFNLKHRIY
|
[
"GO:0008152",
"GO:1901575",
"GO:0016052",
"GO:0043170",
"GO:0009057",
"GO:0000272",
"GO:0009056",
"GO:0005975",
"GO:0044238",
"GO:0008150",
"GO:0005976",
"GO:0071704",
"GO:0004553",
"GO:0042973",
"GO:0016798",
"GO:0015926",
"GO:0003824",
"GO:0008422",
"GO:0003674",
"GO:0016787"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009056",
"GO:0044238",
"GO:0071704",
"GO:1901575",
"GO:0043170",
"GO:0005975",
"GO:0016052",
"GO:0009057",
"GO:0005976",
"GO:0000272"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016787",
"GO:0016798",
"GO:0004553",
"GO:0015926",
"GO:0008422",
"GO:0042973"
] | null |
[
"IPR005200",
"IPR040720",
"IPR040451"
] |
pdb_files/4K35.pdb.gz
| null | null | null |
A0A072VIM5
|
BTB/POZ domain and ankyrin repeat-containing protein NOOT2 (Protein NODULE ROOT 2) (MtNOOT2)
|
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Transcriptional co-regulator involved in the promotion of leaf and floral meristem fate and determinacy (By similarity). Required for the abscission of senescent organs, probably by regulating the cell wall disorganization in abscission zones (AZs, e.g. pulvini at the base of leaves) (By similarity). Involved in the coordination of the symbiotic nodule developmental program; promotes the formation of root nodules by interacting directly with APP1 to modulate the expression of the nuclear transcription factor Y subunit (NF-YA1), a key nodulin (By similarity). Involved in the regulation of indeterminate nodule identity in association with NOOT1 (PubMed:30026291). {ECO:0000250|UniProtKB:G3LSH3, ECO:0000250|UniProtKB:O22286, ECO:0000250|UniProtKB:Q2HW56, ECO:0000269|PubMed:30026291}.
|
Medicago truncatula (Barrel medic) (Medicago tribuloides)
| 492 |
Nucleus {ECO:0000250|UniProtKB:G3LSH3}. Cytoplasm {ECO:0000250|UniProtKB:G3LSH3}. Cell membrane {ECO:0000250|UniProtKB:G3LSH3}; Peripheral membrane protein {ECO:0000250|UniProtKB:G3LSH3}; Cytoplasmic side {ECO:0000250|UniProtKB:G3LSH3}.
|
MSLEETLRSLSLDYLNLLINGQAFSDVTFQVEGRLVHAHRCILAARSLFFRKFFCGPDPPSGLDPIGGGSSRQPTVRPGVIPVNSVGYEVFLLLLQFLYSGQVSIVPQKHEPRPNCGERGCWHTHCTSAVDLALDTLAAARYFGVEQLALLTQKQLVSMVEKASIDDVMKVLIASRKQEMPQLWTTCSHLVAKSGLPPEILAKHLSIDVVAKIEELRLKSSLARRSLMPLHHHHHHHHHHDFGDLEDQKIRRMRRALDSSDVELVKLMVMGEGLNLDEALALHYAVENCSREVVKALLELGAADVNYPAGPAGKTSLHVAAEMVSPEMVAVLLDHHADPTVRTVDGVTPLDILRTLTSDFLFKGAVPGLNHIEPNKLRLCLELVQSAALVLSREENNASNNNNNNNNASSSAAPVYPPMSEDHSSSSSGNNNNNNNSIGNLNLDSRLVYLNLGATQMGGDDDNRHNNSHREAMNRQGGHGCDPSMYHHSHDF
|
[
"GO:0009653",
"GO:0032502",
"GO:0048646",
"GO:0008150",
"GO:0009877",
"GO:0048856"
] |
[
"GO:0008150",
"GO:0032502",
"GO:0009653",
"GO:0048646",
"GO:0048856",
"GO:0009877"
] | null | null |
[
"IPR002110",
"IPR036770",
"IPR000210",
"IPR044284",
"IPR024228",
"IPR011333"
] |
af_db/AF-A0A072VIM5-F1-model_v4.cif.gz
|
3880.A0A072VIM5
|
[
"3880.G7KQS1",
"3880.G7LGW2"
] |
[
{
"protein2": "3880.G7KQS1",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 94,
"database": 664,
"textmining": 98,
"combined_score": 701
},
{
"protein2": "3880.G7LGW2",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 94,
"database": 664,
"textmining": 98,
"combined_score": 701
}
] |
A0A075TMP0
|
Alcohol dehydrogenase patD (EC 1.1.1.-) (Patulin biosynthesis cluster protein D)
|
Alcohol dehydrogenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886). PatD catalyzes the conversion of neopatulin into E-ascladiol (PubMed:30680886). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable) (PubMed:30680886). {ECO:0000269|PubMed:25625822, ECO:0000269|PubMed:30100914, ECO:0000269|PubMed:30680886, ECO:0000305|PubMed:30680886}.
|
Penicillium expansum (Blue mold rot fungus)
| 340 |
Cytoplasm, cytosol {ECO:0000269|PubMed:30680886}.
|
MASTTPSTYKQAVFKEQGAGLTLEEVALTLPKRDEILVKVEACGVCHSDHFAQTNLMGGGFPLVPGHEIIGRVAAVGEGETVWKEGDRIGGAWHGGHDGTCGACKKGFFQMCDNEQVNGISRNGGYAEYCIIRREAAVHIPDHVNAAKYAPMLCAGVTVFNAMRHMKIPPGELVAIQGLGGLGHLALQYANKFGYRVVALSRDSTKEEFARKLGAHEYIDTSREDPVAALQKLGGASLIVSTAPVPEIINPLIQGLGVMGKLLILSIVGGIEVHTGLLVGKGKSIWSWPSGHATDSEDAIAFADLHGIDCLIEEFPLDKCNEAFAAMMEGSVRFRAVITM
|
[
"GO:0008152",
"GO:0044550",
"GO:1901334",
"GO:1901617",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009987",
"GO:0140723",
"GO:1901362",
"GO:0009058",
"GO:0043385",
"GO:0009404",
"GO:0044237",
"GO:1901360",
"GO:0009403",
"GO:0008150",
"GO:1901576",
"GO:0019748",
"GO:0071704",
"GO:0044283",
"GO:0044281",
"GO:0046165",
"GO:0046483",
"GO:0043386",
"GO:1901336",
"GO:0018130",
"GO:0030639",
"GO:0030638",
"GO:0005737",
"GO:0005829",
"GO:0005575",
"GO:0005622",
"GO:0110165",
"GO:0003824",
"GO:0003674",
"GO:0016491"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0009058",
"GO:0044237",
"GO:0019748",
"GO:0071704",
"GO:0044281",
"GO:0044550",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009404",
"GO:1901360",
"GO:1901576",
"GO:0044283",
"GO:0046483",
"GO:0030638",
"GO:1901334",
"GO:1901617",
"GO:1901362",
"GO:0043385",
"GO:0009403",
"GO:0046165",
"GO:0018130",
"GO:0030639",
"GO:0140723",
"GO:0043386",
"GO:1901336"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016491"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0005737",
"GO:0005829",
"GO:0005622"
] |
[
"IPR013149",
"IPR013154",
"IPR011032",
"IPR036291",
"IPR020843"
] |
af_db/AF-A0A075TMP0-F1-model_v4.cif.gz
|
27334.A0A075TMP0
|
[
"27334.A0A0A2JLP4",
"27334.A0A0A2KX52",
"27334.A0A0A2J8Q7",
"27334.A0A0A2J343",
"27334.A0A0A2IWF4",
"27334.A0A0A2IGJ4",
"27334.A0A0A2J370",
"27334.A0A0A2K3W5",
"27334.A0A0A2JY07",
"27334.A0A0A2IY85",
"27334.A0A0A2JSQ8",
"27334.A0A0A2IGG7",
"27334.A0A0A2I4J4",
"27334.A0A0A2JX20",
"27334.A0A0A2JZR1",
"27334.A0A0A2KRT6",
"27334.A0A0A2IYZ9",
"27334.A0A0A2KWN1",
"27334.A0A0A2IFP5",
"27334.A0A0A2IIW2",
"27334.A0A0A2IXQ4"
] |
[
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},
{
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{
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{
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{
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{
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{
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}
] |
A0A075TMP8
|
Cytochrome P450 monooxygenase patI (EC 1.-.-.-) (Patulin biosynthesis cluster protein I) (m-hydroxybenzyl alcohol hydroxylase)
|
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886). PatI catalyzes the conversion of m-hydroxybenzyl alcohol into gentisyl alcohol (PubMed:30680886). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable) (PubMed:30680886). {ECO:0000269|PubMed:25625822, ECO:0000269|PubMed:30100914, ECO:0000269|PubMed:30680886, ECO:0000305|PubMed:30680886}.
|
Penicillium expansum (Blue mold rot fungus)
| 526 |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:30680886}; Single-pass membrane protein {ECO:0000269|PubMed:30680886}.
|
MDILQLAPTHLLAILLSSTSALFLITYLLRAGHRPSDLPNGPPTVPLFGNELQVPKSDAHFQFSRWAKEYGGFFTLKRYNNTTIVISDQKLIKTLLDKKSNIYSHRPASLVSHLITQSDHLLVMQYGERWRMLRKTIHQYFMEPRCERDHWKVQEAEAKQMLHDYLTMPEDHMLHPKRYSNSITNSLVFGIRTKTVHDEYMKKLFYLMDKWSLVQELGATPPVDSFALLRYVPQWMLGNWRNRAVEVGDLMQSLYQTVLDQVKERRQRGIQRDSFMDRVLDTLKQTPLSENELRFLGGVLMEGGSDTSSSLILTIIQAMTKYPEVQAKAHAQIDSIIGHNRSPAWSDWSKLPYINMIIKESHRWRPVSPLGVPHAVAEDDHIDGKLIPQGSSIVLNVWGMHHDSDRWQEPEHFQPERFADFPALASGYAGSERRDHLGYGAGRRICPGIHLAERNLIIGIAKLLWAFEFLEPLGSDSDISAHSGASKGFLHCPKDYGCVIRLRSPEKRETIMREFAEAQEVFARFD
|
[
"GO:0008152",
"GO:0044550",
"GO:1901334",
"GO:1901617",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009987",
"GO:0140723",
"GO:1901362",
"GO:0009058",
"GO:0043385",
"GO:0009404",
"GO:0044237",
"GO:1901360",
"GO:0009403",
"GO:0008150",
"GO:1901576",
"GO:0019748",
"GO:0071704",
"GO:0044283",
"GO:0044281",
"GO:0046165",
"GO:0046483",
"GO:0043386",
"GO:1901336",
"GO:0018130",
"GO:0030639",
"GO:0030638",
"GO:0005622",
"GO:0043229",
"GO:0043226",
"GO:0110165",
"GO:0005783",
"GO:0005737",
"GO:0005575",
"GO:0043227",
"GO:0012505",
"GO:0043231",
"GO:0003824",
"GO:0004497",
"GO:0003674",
"GO:0016491"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0009058",
"GO:0044237",
"GO:0019748",
"GO:0071704",
"GO:0044281",
"GO:0044550",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009404",
"GO:1901360",
"GO:1901576",
"GO:0044283",
"GO:0046483",
"GO:0030638",
"GO:1901334",
"GO:1901617",
"GO:1901362",
"GO:0043385",
"GO:0009403",
"GO:0046165",
"GO:0018130",
"GO:0030639",
"GO:0140723",
"GO:0043386",
"GO:1901336"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016491",
"GO:0004497"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0005622",
"GO:0043226",
"GO:0005737",
"GO:0012505",
"GO:0043229",
"GO:0005783",
"GO:0043227",
"GO:0043231"
] |
[
"IPR001128",
"IPR002401",
"IPR036396",
"IPR050364"
] |
af_db/AF-A0A075TMP8-F1-model_v4.cif.gz
|
27334.A0A075TMP8
| null | null |
A0A075TRC0
|
6-methylsalicylic acid synthase (6MSAS) (EC 2.3.1.165) (Non-reducing polyketide synthase patK) (Patulin biosynthesis cluster protein K)
|
6-methylsalicylic acid synthase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886, PubMed:35339702). PatK catalyzes the first step of the pathway which is the synthesis of 6-methylsalicylic acid via condensation of 1 acetate and 3 malonate units (PubMed:30680886). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable) (PubMed:30680886). {ECO:0000269|PubMed:25625822, ECO:0000269|PubMed:30100914, ECO:0000269|PubMed:30680886, ECO:0000269|PubMed:35339702, ECO:0000305|PubMed:30680886}.
|
Penicillium expansum (Blue mold rot fungus)
| 1,776 |
Cytoplasm, cytosol {ECO:0000269|PubMed:30680886}.
|
MHSVSPSTYPSGGTSPAPADTPGTEYSEYEFSNDVAVVGMACRVAGGNHNPELLWQSLLSQKSAVGEIPEMRWEPYYRRDPRNAKELKKTTSRGYFLDRLEDFDCQFFGISPKEAEQMDPQQRVSLEVASEALEDAGIPAKSLSGSDTAVFWGVNSDDYSKLVLEDLPNVEAWMGIGTAYCGVPNRISYHLNLMGPSTAVDAACASSLVAVHHGVQAIRLGESQVAIVGGVNALCGPGLTRVLDKAGAISSDGSCKSFDDDAHGYARGEGAGALVLKSLHRALLDHDNVLAVIKGSAVAQDGKTNGIMAPNAKAQQLAARTALNVAGVDPSTVRYVEAHATSTPLGDPTEISAIAGVYGTNRPADDPCYIGSIKPNIGHLEAGAGVMGFIKAILTIQKGVLPPQANLTNLNSRIDWKTAGVKVVQEATPWPSSDPIRRAGVCSYGYGGTVSHAVIEEFNPILRPDPLDDGAATGPGLLLLSGPQEKRLALQAKTLREWMTADGKDNNLSEILTTLATRRDHHDYRAALVVDDHLDATQVLQALANGTDHSFTTQSRVLGADVSKDVVWVFSGHGAQWPDMGKQLIHNPVFFAAIQPLDELIQAEIGLSPIELLRTGDFESSDRVQILTYLMQIGLSAILQSNGITPQAVIGHSVGEIAASVVAGALTSAEGALIVTRRALLYRQVMGKGGMILVNLPSAETEEILGRRQDLVVAIDSSPSSCVVAGDKDIVAETAEAFKARGVKTFTVKSDIAFHSPTLNVLMDPLRDALGQALAPTVHIKLYSTALVDPRGQDVRDLEYWTGNMVNRVRLTSAIQAAVEDGYRLFLEVSTHPVVSHSINETLMDAGLEDFAVIPTLLRKKPTEKHILHSIAQLHCRGAEVNWAAQMPGRWATGLPTTTWMHKPIWRKIETAPLHTGLTHDVEKHTLLGQRIPVPGTDTFVYTSRLDNETKPFPGSHPLHGTEIVPAAGLINTFLKGTGGQMLQNVVLRVPVAINAPRSVQVVVQQDQVKVVSRLISSDPSLSDDDASWVTHTTAYWDRKVLGSADRIDLAAVKARLTTKLADNFSIDYLDKVGVSAMGFPWAVTEHYRDTKQMLARVDVNPAVLGDDPLPWDSSSWAPVLDAATSVGSTVFQTAALRMPAQIERVEIFTSEDPPKISYLFVEEASDSVPTSHVSVLSETGEVLAKFTAMRFSEIEGTPGVSGSMESLVHQIAWPPATPAEEPLLITKVILVSPDATARAQYAATLPTQVQSFQFSTTEDFFSNASSLPLEKGTVVAYIPGEVASLAEVPAASESFTWNLLELIKFIVNGSLPIKVFTLTSSVGDGQTPTALAQSPLIGLARIIASEHPDLGSLIDIEEPKIPLSTMRYIQGADVIRISDGIARVSRFRSLPRTKLRPASEGPRLLPRPDGTYLITGGLGILGLEVADFLVEKGARRLLLISRRALPPRRTWDQVSEDLQPTIAKIRLLESRGASVHVLPLDITKPDAVEQLSTALDRLSLPAVQGVVHAAGVLDNEMVLQTTRDAFNRVLAPKIAGALALHEVFPPKSVDFFVMFSSCGNLVGFTGQASYGSGNAFLDTLATHRARLGDSGAVAFQWTAWRGLGMGSSTDFINAELEAKGITDVTRDEAFAAWQHLAKYDIDHGVVLRSLAIDDGEPVPVPILNDIVVRRVSELSGSAQAAAGSSGNDAVPSSGPELKAYLDEKIRGCVAKVLQMTAEDVDSKAALADLGVDSVMTVTLRRQLQQTLKIPVPPTLTWSHPTVSHLVVWFAEKIGK
|
[
"GO:0008152",
"GO:0044550",
"GO:1901334",
"GO:1901617",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009987",
"GO:0140723",
"GO:1901362",
"GO:0009058",
"GO:0043385",
"GO:0009404",
"GO:0044237",
"GO:1901360",
"GO:0009403",
"GO:0008150",
"GO:1901576",
"GO:0019748",
"GO:0071704",
"GO:0044283",
"GO:0044281",
"GO:0046165",
"GO:0046483",
"GO:0043386",
"GO:1901336",
"GO:0018130",
"GO:0030639",
"GO:0030638",
"GO:0005737",
"GO:0005829",
"GO:0005575",
"GO:0005622",
"GO:0110165",
"GO:0016747",
"GO:0016740",
"GO:0003674",
"GO:0050641",
"GO:0016746",
"GO:0003824"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0009058",
"GO:0044237",
"GO:0019748",
"GO:0071704",
"GO:0044281",
"GO:0044550",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009404",
"GO:1901360",
"GO:1901576",
"GO:0044283",
"GO:0046483",
"GO:0030638",
"GO:1901334",
"GO:1901617",
"GO:1901362",
"GO:0043385",
"GO:0009403",
"GO:0046165",
"GO:0018130",
"GO:0030639",
"GO:0140723",
"GO:0043386",
"GO:1901336"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016740",
"GO:0016746",
"GO:0016747",
"GO:0050641"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0005737",
"GO:0005829",
"GO:0005622"
] |
[
"IPR001227",
"IPR036736",
"IPR014043",
"IPR016035",
"IPR018201",
"IPR014031",
"IPR014030",
"IPR016036",
"IPR036291",
"IPR032821",
"IPR020841",
"IPR042104",
"IPR020807",
"IPR049552",
"IPR013968",
"IPR049900",
"IPR050091",
"IPR020806",
"IPR009081",
"IPR006162",
"IPR016039"
] |
af_db/AF-A0A075TRC0-F1-model_v4.cif.gz
|
27334.A0A075TRC0
|
[
"27334.A0A0A2KDD9",
"27334.A0A0A2KG16",
"27334.A0A0A2J7Z2",
"27334.A0A0A2KYF7",
"27334.A0A0A2JXU9",
"27334.A0A0A2IFY0",
"27334.A0A0A2KZA4"
] |
[
{
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"fusion": 635,
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"coexpression": 79,
"experimental": 271,
"database": 341,
"textmining": 0,
"combined_score": 817
},
{
"protein2": "27334.A0A0A2KG16",
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"fusion": 699,
"cooccurence": 0,
"coexpression": 94,
"experimental": 67,
"database": 363,
"textmining": 0,
"combined_score": 816
},
{
"protein2": "27334.A0A0A2J7Z2",
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"coexpression": 79,
"experimental": 271,
"database": 341,
"textmining": 53,
"combined_score": 887
},
{
"protein2": "27334.A0A0A2KYF7",
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"database": 341,
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},
{
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"database": 341,
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},
{
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"fusion": 791,
"cooccurence": 0,
"coexpression": 79,
"experimental": 271,
"database": 341,
"textmining": 0,
"combined_score": 895
},
{
"protein2": "27334.A0A0A2KZA4",
"neighborhood": 0,
"fusion": 763,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 239,
"textmining": 0,
"combined_score": 812
}
] |
A0A075TXZ1
|
6-methylsalicylic acid decarboxylase (EC 4.1.1.52) (Patulin biosynthesis cluster protein G)
|
6-methylsalicylic acid decarboxylase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886). PatG catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (PubMed:30680886). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable) (PubMed:30680886). {ECO:0000269|PubMed:25625822, ECO:0000269|PubMed:30100914, ECO:0000269|PubMed:30680886, ECO:0000305|PubMed:30680886}.
|
Penicillium expansum (Blue mold rot fungus)
| 324 |
Cytoplasm, cytosol {ECO:0000269|PubMed:30680886}.
|
MAKIDVHHHFYPPAMRQALDRAGGDPSGWYIPPWTLELDQDITRQMKVTTTILSVTAPGPGIEPDVTKAAALARSCNESAAAIRDAKPQQYGFFASVPSLFDTAAVLKEIEYACTTLRADGVTLFTRYGKGSNYLGHAAFRPIWADLSRRGAVVFIHPTHPVDTQLINTWLPQPMFDYPHETGRAAMDLLTSGILQDYPGCKIILSHAGGTLPYLIHRAATMLPLMPRTLGLSTEELVEAARTFYFDTAISSNPVTLKALFEFAAPGHVLFGSDFPNAPHDAILRFTNFLEAYELPEETKRQVDSGAALELFPRLKGILDKAKL
|
[
"GO:0008152",
"GO:0044550",
"GO:1901334",
"GO:1901617",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009987",
"GO:0140723",
"GO:1901362",
"GO:0009058",
"GO:0043385",
"GO:0009404",
"GO:0044237",
"GO:1901360",
"GO:0009403",
"GO:0008150",
"GO:1901576",
"GO:0019748",
"GO:0071704",
"GO:0044283",
"GO:0044281",
"GO:0046165",
"GO:0046483",
"GO:0043386",
"GO:1901336",
"GO:0018130",
"GO:0030639",
"GO:0030638",
"GO:0005737",
"GO:0005829",
"GO:0005575",
"GO:0005622",
"GO:0110165",
"GO:0016830",
"GO:0003674",
"GO:0016831",
"GO:0047596",
"GO:0003824",
"GO:0016829"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0009058",
"GO:0044237",
"GO:0019748",
"GO:0071704",
"GO:0044281",
"GO:0044550",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009404",
"GO:1901360",
"GO:1901576",
"GO:0044283",
"GO:0046483",
"GO:0030638",
"GO:1901334",
"GO:1901617",
"GO:1901362",
"GO:0043385",
"GO:0009403",
"GO:0046165",
"GO:0018130",
"GO:0030639",
"GO:0140723",
"GO:0043386",
"GO:1901336"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016829",
"GO:0016830",
"GO:0016831",
"GO:0047596"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0005737",
"GO:0005829",
"GO:0005622"
] |
[
"IPR032465",
"IPR006680",
"IPR032466"
] |
af_db/AF-A0A075TXZ1-F1-model_v4.cif.gz
|
27334.A0A075TXZ1
|
[
"27334.A0A0A2K0C4"
] |
[
{
"protein2": "27334.A0A0A2K0C4",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 250,
"experimental": 0,
"database": 524,
"textmining": 236,
"combined_score": 703
}
] |
A0A089QRB9
|
Mycolipanoate synthase (EC 2.3.1.252) (Mycocerosic acid synthase-like polyketide synthase) (MAS-like PKS) (Mycolipanoic/mycolipenic acids synthase-like polyketide synthase)
|
Polyketide synthase involved in the biosynthesis of methyl-branched fatty acids such as mycolipanoic, mycolipenic (phthienoic) and mycolipodienoic acids required for the synthesis of a major class of polyacylated trehaloses. Catalyzes the elongation of CoA esters of long-chain fatty acids by incorporation of three methylmalonyl (but not malonyl) residues, to form trimethyl-branched fatty-acids. {ECO:0000269|PubMed:12207710}.
|
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
| 2,085 |
Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
|
MRTATATSVAVIGMACRLPGGIDSPQRLWEALLRGDDLVGEIPADRWDANVYYDPEPGVPGRSVSRWGAFLDDVGGFDCDFFGLTEREATAIDPQHRLLLEVSWEAIEHAGVDPATLAESQTGVFVGLTHGDYELLSADCGAAEGPYGFTGTSNSFASGRVAYTLGLHGPAVTVDTACSSGLTAVHQACRSLDDGESDLALAGGVVVTLEPRKSVSGSLQGMLSPTGRCHAFDEAADGFVSGEGCVVLLLKRLPDAVRDGDRVLAIVRGTAANQDGRTVNIAAPSAQAQIAVYQQALAAAGVEASTVGMVEAHGTGTPVGDPVEYASLAAVYGTEGPCALTSVKTNFGHLQSASGPLGLMKTILALRHGVVPQNLHFCRLPDQLAEIDTELFVPQANTSWPDNTGQPRRAAVSSYGMSGTNVHAILEQAPVSEPAASGPELTPEAGGLALFPVSATSAEQLHVTAARLADWVDQNGNAGSRVSMRDLGYTLSCRRAHRPVRTVVTASSFDELSAALRDVAGDQIPYQPAVGHDDRGPVWVFSGQGSQWPGMGTELLVAEPVFAATVAAMEPVIARESGFSVTEAMSAPQTVSGIDRVQPTIFAVQVALAAALKSYGVRPGAIIGHSLGEAAAAVVAGALSLHDGLRVICRRSRLMSRIAGSGAMASVELPGQQVLSELAIRGISDVVLSVVASPTSTVVGGATQSIRDLVAAWEQQDVLAREVAVDVASHTPQVDPILDELLEVLAEVDPTAPEIPYYSATLWDPRERPSFTGEYWVENLRYTVRFAAAVQAALKDGYRVFGELAPHPLLTYAVEQNAASLDMPIATLAAMRRGEQLPFGLRGFVADVHNAGAKVDFSVQYPDGRLVDAPLPSWTHRTLMLSREDSHRSHTGAVQAVHPLLGAHVHLLEEPERHVWQAGVGTGAHPWLGDHRIHNVAAFPGAAYCEMALAAARTTLGELSEVRDIKFEQTLLLDEQTVVSSAATIAAPGILQFAVESHQEGEPARRASAMLHALEEMPQPPGYDTNALTAAHESSMSGEELRKMFNSLGIQYGPAFSGLVAVHTARGDVTTVLAEVALPGAIRSQQSAYASHPALLDACFQSVLVHPEVQKATVGGLMLPVGVRRLRNYHSTRSAHYCLARVTSSSRAGECEADLDVFDQAGTVLLTVEGLRLAAGISEHERANRVFDERLLTIEWERGELPEVPQIDAGSWLLLSASEADPLTAQLADALNAVGAQSTSVASASDVAQLRSLLGGRLTGVVVVTGPPTGGLTQCGRDYVSQLVGIARELAELPGEPPRLFVVTRSAASVLPSDLANLEQAGLRGLMRVIDSEHPHLGATAIDVDNDETVAALVASQLQSGSQEDETAWRNGIWYTARLRPGPLRPAERRTAVVEYRRDGMRLQIRTPGDLESLEFVTFDRVAPGPGEIEVAVTASSVNFADVLVAFGRYPTFEGYRQQLGIDFAGVVTAVGPDVTEHRIGDHVGGMSANGCWSTFVRCDARLAVTLPPELPVAAAAAVPTASATAWYALHDLARICSDDKVLIHSGTGGVGQAAIAIARAAGCEIFATAGSAQRRQLLHDMGVEHVYDSRSTEFAEQIRGDTDGYGVDVVLNSLPGAAQRAGIELLAFGGRFVEIGKRDIYGDTRLGLFPFRRNLSLYAVDLALLTHSHPHTVRRLLKTVYQHTVEGTLPVPQTTHYPIHDAAVAIRLVGGAGHTGKVVLDVPRTGEGVAVVPPEQVRTSRPDGAYLVTGGLGGLGLFLAGELAAAGCGRIVLNSRSTPSPHATRVIERLRAAGADIQVECGDIADAATAHRVVAVATASGLPVRGVLHAAAVVEDATLANVTDELIDRCWAPKVHGAWNIHRATAAQPLEWFCLFSSAAALVGSPGQGAYAAANSWLDAFAHWRRAQGLPATSIAWGAWAEIGRATALAEGTGAAIAPAEGARAFQTLLRYGRAYSGYAPIMGTPWLTAFAQRSRFAEAFHATGQNQPATGKFLAELGSLPREEWPRTVRRLVSDQISLLLRRTIDPDRPLSDYGLDSLGNLELRTRIETETGIRVSPTKITTVRGLAEHVCDELAAAQSAPV
|
[
"GO:0008152",
"GO:0044255",
"GO:0006633",
"GO:0019752",
"GO:0009987",
"GO:0044249",
"GO:0006631",
"GO:0072330",
"GO:0009058",
"GO:0044237",
"GO:0008150",
"GO:1901576",
"GO:0046394",
"GO:0006629",
"GO:0071704",
"GO:0044283",
"GO:0044281",
"GO:0097089",
"GO:0043436",
"GO:0016053",
"GO:0008610",
"GO:0006082",
"GO:0044238",
"GO:0032787",
"GO:1902321"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0009058",
"GO:0044237",
"GO:0071704",
"GO:0044281",
"GO:0044238",
"GO:0044255",
"GO:0044249",
"GO:1901576",
"GO:0006629",
"GO:0044283",
"GO:0006082",
"GO:0006631",
"GO:0043436",
"GO:0016053",
"GO:0008610",
"GO:0006633",
"GO:0019752",
"GO:0046394",
"GO:0097089",
"GO:0072330",
"GO:0032787",
"GO:1902321"
] | null | null |
[
"IPR001227",
"IPR036736",
"IPR014043",
"IPR016035",
"IPR013149",
"IPR013154",
"IPR011032",
"IPR018201",
"IPR014031",
"IPR014030",
"IPR016036",
"IPR053386",
"IPR036291",
"IPR032821",
"IPR020841",
"IPR042104",
"IPR020807",
"IPR049551",
"IPR049552",
"IPR020843",
"IPR013968",
"IPR049900",
"IPR050091",
"IPR020806",
"IPR009081",
"IPR016039"
] |
af_db/AF-A0A089QRB9-F1-model_v4.cif.gz
|
83332.Rv1181
|
[
"83332.Rv2935",
"83332.Rv2930",
"83332.Rv1527c",
"83332.Rv3145",
"83332.Rv3800c",
"83332.Rv0101",
"83332.Rv2245",
"83332.Rv2946c",
"83332.Rv2934",
"83332.Rv2947c",
"83332.Rv3391",
"83332.Rv3157",
"83332.Rv1978",
"83332.Rv2243",
"83332.Rv2048c",
"83332.Rv3150",
"83332.Rv2932",
"83332.Rv2380c",
"83332.Rv2931",
"83332.Rv3148",
"83332.Rv2933",
"83332.Rv1662",
"83332.Rv2442c",
"83332.Rv3824c",
"83332.Rv3823c",
"83332.Rv3820c",
"83332.Rv1528c",
"83332.Rv1665",
"83332.Rv1125",
"83332.Rv0310c",
"83332.Rv2383c",
"83332.Rv2524c",
"83332.Rv1182",
"83332.Rv0163",
"83332.Rv1660",
"83332.Rv3825c",
"83332.Rv3152",
"83332.Rv2379c",
"83332.Rv3153",
"83332.Rv1661",
"83332.Rv3146",
"83332.Rv1185c",
"83332.Rv1183",
"83332.Rv3149",
"83332.Rv3158",
"83332.Rv3147",
"83332.Rv2940c",
"83332.Rv2475c",
"83332.Rv1180",
"83332.Rv0757",
"83332.Rv2590",
"83332.Rv3151",
"83332.Rv1937",
"83332.Rv2941",
"83332.Rv2382c"
] |
[
{
"protein2": "83332.Rv2935",
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"coexpression": 60,
"experimental": 180,
"database": 720,
"textmining": 209,
"combined_score": 845
},
{
"protein2": "83332.Rv2930",
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"fusion": 14,
"cooccurence": 0,
"coexpression": 174,
"experimental": 313,
"database": 328,
"textmining": 383,
"combined_score": 747
},
{
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"coexpression": 280,
"experimental": 795,
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"combined_score": 958
},
{
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"coexpression": 90,
"experimental": 449,
"database": 561,
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"combined_score": 779
},
{
"protein2": "83332.Rv3800c",
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"coexpression": 676,
"experimental": 180,
"database": 0,
"textmining": 582,
"combined_score": 957
},
{
"protein2": "83332.Rv0101",
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"combined_score": 968
},
{
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"combined_score": 732
},
{
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"combined_score": 912
},
{
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"experimental": 180,
"database": 720,
"textmining": 85,
"combined_score": 836
},
{
"protein2": "83332.Rv2947c",
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"database": 0,
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"combined_score": 982
},
{
"protein2": "83332.Rv3391",
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"experimental": 134,
"database": 0,
"textmining": 389,
"combined_score": 757
},
{
"protein2": "83332.Rv3157",
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"experimental": 449,
"database": 561,
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},
{
"protein2": "83332.Rv1978",
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"fusion": 0,
"cooccurence": 726,
"coexpression": 42,
"experimental": 0,
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"textmining": 90,
"combined_score": 743
},
{
"protein2": "83332.Rv2243",
"neighborhood": 141,
"fusion": 0,
"cooccurence": 0,
"coexpression": 601,
"experimental": 787,
"database": 549,
"textmining": 269,
"combined_score": 971
},
{
"protein2": "83332.Rv2048c",
"neighborhood": 544,
"fusion": 0,
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"experimental": 795,
"database": 0,
"textmining": 471,
"combined_score": 969
},
{
"protein2": "83332.Rv3150",
"neighborhood": 45,
"fusion": 0,
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"coexpression": 243,
"experimental": 449,
"database": 446,
"textmining": 248,
"combined_score": 803
},
{
"protein2": "83332.Rv2932",
"neighborhood": 481,
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"coexpression": 76,
"experimental": 232,
"database": 720,
"textmining": 332,
"combined_score": 940
},
{
"protein2": "83332.Rv2380c",
"neighborhood": 200,
"fusion": 6,
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"coexpression": 445,
"experimental": 473,
"database": 0,
"textmining": 289,
"combined_score": 856
},
{
"protein2": "83332.Rv2931",
"neighborhood": 151,
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"cooccurence": 306,
"coexpression": 74,
"experimental": 180,
"database": 720,
"textmining": 250,
"combined_score": 884
},
{
"protein2": "83332.Rv3148",
"neighborhood": 43,
"fusion": 0,
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"coexpression": 179,
"experimental": 449,
"database": 564,
"textmining": 163,
"combined_score": 813
},
{
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"experimental": 795,
"database": 720,
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"combined_score": 990
},
{
"protein2": "83332.Rv1662",
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"cooccurence": 315,
"coexpression": 70,
"experimental": 433,
"database": 0,
"textmining": 176,
"combined_score": 701
},
{
"protein2": "83332.Rv2442c",
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"cooccurence": 0,
"coexpression": 461,
"experimental": 457,
"database": 0,
"textmining": 282,
"combined_score": 775
},
{
"protein2": "83332.Rv3824c",
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"fusion": 0,
"cooccurence": 400,
"coexpression": 551,
"experimental": 473,
"database": 0,
"textmining": 690,
"combined_score": 955
},
{
"protein2": "83332.Rv3823c",
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"experimental": 138,
"database": 0,
"textmining": 695,
"combined_score": 750
},
{
"protein2": "83332.Rv3820c",
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"experimental": 473,
"database": 0,
"textmining": 393,
"combined_score": 877
},
{
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},
{
"protein2": "83332.Rv1665",
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"experimental": 284,
"database": 720,
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},
{
"protein2": "83332.Rv1125",
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
"protein2": "83332.Rv2379c",
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},
{
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},
{
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},
{
"protein2": "83332.Rv3146",
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"coexpression": 408,
"experimental": 449,
"database": 564,
"textmining": 226,
"combined_score": 875
},
{
"protein2": "83332.Rv1185c",
"neighborhood": 93,
"fusion": 10,
"cooccurence": 0,
"coexpression": 210,
"experimental": 313,
"database": 328,
"textmining": 691,
"combined_score": 879
},
{
"protein2": "83332.Rv1183",
"neighborhood": 475,
"fusion": 0,
"cooccurence": 0,
"coexpression": 797,
"experimental": 138,
"database": 0,
"textmining": 700,
"combined_score": 968
},
{
"protein2": "83332.Rv3149",
"neighborhood": 55,
"fusion": 0,
"cooccurence": 0,
"coexpression": 419,
"experimental": 449,
"database": 518,
"textmining": 228,
"combined_score": 866
},
{
"protein2": "83332.Rv3158",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 67,
"experimental": 449,
"database": 556,
"textmining": 136,
"combined_score": 776
},
{
"protein2": "83332.Rv3147",
"neighborhood": 43,
"fusion": 0,
"cooccurence": 0,
"coexpression": 450,
"experimental": 472,
"database": 564,
"textmining": 255,
"combined_score": 893
},
{
"protein2": "83332.Rv2940c",
"neighborhood": 544,
"fusion": 0,
"cooccurence": 61,
"coexpression": 285,
"experimental": 795,
"database": 0,
"textmining": 443,
"combined_score": 958
},
{
"protein2": "83332.Rv2475c",
"neighborhood": 119,
"fusion": 0,
"cooccurence": 0,
"coexpression": 467,
"experimental": 454,
"database": 0,
"textmining": 135,
"combined_score": 748
},
{
"protein2": "83332.Rv1180",
"neighborhood": 646,
"fusion": 806,
"cooccurence": 756,
"coexpression": 862,
"experimental": 180,
"database": 900,
"textmining": 85,
"combined_score": 999
},
{
"protein2": "83332.Rv0757",
"neighborhood": 44,
"fusion": 0,
"cooccurence": 0,
"coexpression": 76,
"experimental": 0,
"database": 0,
"textmining": 703,
"combined_score": 714
},
{
"protein2": "83332.Rv2590",
"neighborhood": 532,
"fusion": 0,
"cooccurence": 0,
"coexpression": 437,
"experimental": 143,
"database": 0,
"textmining": 675,
"combined_score": 916
},
{
"protein2": "83332.Rv3151",
"neighborhood": 42,
"fusion": 0,
"cooccurence": 0,
"coexpression": 194,
"experimental": 449,
"database": 446,
"textmining": 173,
"combined_score": 769
},
{
"protein2": "83332.Rv1937",
"neighborhood": 126,
"fusion": 0,
"cooccurence": 0,
"coexpression": 186,
"experimental": 382,
"database": 150,
"textmining": 585,
"combined_score": 816
},
{
"protein2": "83332.Rv2941",
"neighborhood": 93,
"fusion": 9,
"cooccurence": 0,
"coexpression": 176,
"experimental": 313,
"database": 328,
"textmining": 318,
"combined_score": 721
},
{
"protein2": "83332.Rv2382c",
"neighborhood": 72,
"fusion": 681,
"cooccurence": 742,
"coexpression": 57,
"experimental": 180,
"database": 0,
"textmining": 135,
"combined_score": 937
}
] |
A0A059TC02
|
Cinnamoyl-CoA reductase 1 (Ph-CCR1) (EC 1.2.1.44) (Coniferylaldehyde synthase) (Coumaroyl-CoA reductase) (Feruloyl-CoA reductase) (Sinapoyl-CoA reductase)
|
Involved in the latter stages of lignin biosynthesis (PubMed:24985707). Catalyzes one of the last steps of monolignol biosynthesis, the conversion of cinnamoyl-CoAs into their corresponding cinnamaldehydes (PubMed:24985707, PubMed:25217505). Mediates the conversion of feruloyl CoA to coniferylaldehyde (PubMed:24985707, PubMed:25217505). Also active toward p-coumaroyl-CoA and sinapoyl-CoA (PubMed:24985707, PubMed:25217505). Involved in the production of floral volatile phenylpropanoids in flowers of fragrant cultivars (e.g. cv. Mitchell and cv. V26) from cinnamic acid, a common precursor with the anthocyanin biosynthesis pathway involved in flower pigmentation (PubMed:24985707). {ECO:0000269|PubMed:24985707, ECO:0000269|PubMed:25217505}.
|
Petunia hybrida (Petunia)
| 333 |
Cytoplasm {ECO:0000269|PubMed:24985707}.
|
MRSVSGQVVCVTGAGGFIASWLVKILLEKGYTVRGTVRNPDDPKNGHLRELEGAKERLTLCKADLLDYQSLREAINGCDGVFHTASPVTDDPEQMVEPAVIGTKNVINAAAEANVRRVVFTSSIGAVYMDPNRDPETVVDETCWSDPDFCKNTKNWYCYGKMVAEQAAWEEAKEKGVDLVVINPVLVQGPLLQTTVNASVLHILKYLTGSAKTYANSVQAYVDVKDVALAHILLYETPEASGRYLCAESVLHRGDVVEILSKFFPEYPIPTKCSDVTKPRVKPYKFSNQKLKDLGLEFTPVKQCLYETVKSLQEKGHLPIPTQKDEPIIRIQP
|
[
"GO:0008152",
"GO:0044550",
"GO:0019752",
"GO:0006631",
"GO:1901362",
"GO:0009058",
"GO:0044237",
"GO:1901360",
"GO:0008150",
"GO:1901576",
"GO:0048511",
"GO:0006629",
"GO:0044281",
"GO:0043436",
"GO:0019438",
"GO:0006082",
"GO:0009698",
"GO:0032787",
"GO:0007623",
"GO:0006690",
"GO:0044255",
"GO:0009699",
"GO:0009987",
"GO:0044249",
"GO:0006725",
"GO:0009808",
"GO:0010597",
"GO:0019748",
"GO:0071704",
"GO:0019372",
"GO:0044238",
"GO:0009809",
"GO:0110165",
"GO:0005737",
"GO:0005575",
"GO:0005622",
"GO:0003674",
"GO:0016621",
"GO:0016620",
"GO:0003824",
"GO:0016903",
"GO:0016491"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0048511",
"GO:0009987",
"GO:0009058",
"GO:0044237",
"GO:0044281",
"GO:0007623",
"GO:0019748",
"GO:0071704",
"GO:0044238",
"GO:0044550",
"GO:1901360",
"GO:1901576",
"GO:0006629",
"GO:0006082",
"GO:0009698",
"GO:0044255",
"GO:0044249",
"GO:0006725",
"GO:0006631",
"GO:1901362",
"GO:0043436",
"GO:0019438",
"GO:0009699",
"GO:0009808",
"GO:0019752",
"GO:0019372",
"GO:0009809",
"GO:0032787",
"GO:0006690",
"GO:0010597"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016491",
"GO:0016903",
"GO:0016620",
"GO:0016621"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0005737",
"GO:0005622"
] |
[
"IPR001509",
"IPR036291",
"IPR050425"
] |
pdb_files/4R1S.pdb.gz
| null | null | null |
A0A072UR65
|
Class V chitinase CHIT5b (MtCHIT5b) (EC 3.2.1.14)
|
Possesses chitinase activity in vitro toward glycol chitin, carboxymethyl-chitin, colloidal chitin, and the chitin oligosaccharides (N-acetylglucosamine) (GlcNAc)6 and (GlcNAc)5 (PubMed:27383628). Hydrolyzes (GlcNAc)6 into (GlcNAc)4 and (GlcNAc)2, or two (GlcNAc)3 molecules (PubMed:27383628). Has the capacity to reduce hyphal growth of the fungus Trichoderma viride in an agar-plate bioassay (PubMed:27383628). {ECO:0000269|PubMed:27383628}.
|
Medicago truncatula (Barrel medic) (Medicago tribuloides)
| 379 | null |
MANILNLKHLLTLALILLALATKSSTSSSSSITRVKGIYWLENPFFPPTTVDTSLFTHIFYSFLTPNNITYKLEISSSQILSLNTFTKTFKTKSPPAATLFSIGGAGSNSSLLAFIASDPPACAAFINSTIDVARTFGFDGIDLDWEFPKNTKEMNDLGEMLFQWRKAISDEGATTGRPPLLLTAAVYFAVNFSIYGEPRMYPVNSINENLDWVNVMSYELRGPRSNKTGAPSGTFDPKSNVSVVSGLLSWIHSGVVPEKLVMGMPLYGKSWKLRDPNVHGIGAPSVGSGPGVNGLMAYFQVLDFNRQKSAKVEYDVDTASVYSYSGSTWIGYDNPFTVSIKVGFAQALKLRGYFFWVAGLDTLDWKIATQASKAWKLV
|
[
"GO:0008152",
"GO:0009605",
"GO:0006030",
"GO:0006026",
"GO:0009057",
"GO:0008150",
"GO:1901564",
"GO:0006032",
"GO:0043207",
"GO:1901565",
"GO:0050896",
"GO:1901072",
"GO:1901136",
"GO:1901071",
"GO:0009607",
"GO:0050832",
"GO:0006040",
"GO:0006807",
"GO:0046348",
"GO:0044419",
"GO:0006952",
"GO:0006950",
"GO:0071704",
"GO:1901575",
"GO:0043170",
"GO:0051707",
"GO:0009620",
"GO:1901135",
"GO:0009056",
"GO:0098542",
"GO:0006022",
"GO:0004568",
"GO:0004553",
"GO:0003674",
"GO:0016787",
"GO:0016798",
"GO:0003824"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0050896",
"GO:0044419",
"GO:0009605",
"GO:0009607",
"GO:0006807",
"GO:0006950",
"GO:0071704",
"GO:0051707",
"GO:0009056",
"GO:1901564",
"GO:0043207",
"GO:0006952",
"GO:1901575",
"GO:0043170",
"GO:0009620",
"GO:1901135",
"GO:0098542",
"GO:0009057",
"GO:1901565",
"GO:1901136",
"GO:0050832",
"GO:0006040",
"GO:0006022",
"GO:0006030",
"GO:0006026",
"GO:1901071",
"GO:0046348",
"GO:0006032",
"GO:1901072"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016787",
"GO:0016798",
"GO:0004553",
"GO:0004568"
] | null |
[
"IPR011583",
"IPR029070",
"IPR001223",
"IPR001579",
"IPR017853",
"IPR050314"
] |
af_db/AF-A0A072UR65-F1-model_v4.cif.gz
|
3880.A0A072UR65
|
[
"3880.A0A072W2M8",
"3880.G7IQQ5",
"3880.A0A072TYG8"
] |
[
{
"protein2": "3880.A0A072W2M8",
"neighborhood": 73,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 777,
"textmining": 195,
"combined_score": 818
},
{
"protein2": "3880.G7IQQ5",
"neighborhood": 73,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 777,
"textmining": 195,
"combined_score": 818
},
{
"protein2": "3880.A0A072TYG8",
"neighborhood": 73,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 777,
"textmining": 195,
"combined_score": 818
}
] |
A0A075TRB3
|
Isoepoxydon dehydrogenase patN (IDH) (EC 1.1.1.-) (Patulin biosynthesis cluster protein N)
|
Isoepoxydon dehydrogenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886). PatN catalyzes the conversion of isoepoxydon into phyllostine (PubMed:30680886). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable) (PubMed:30680886). {ECO:0000269|PubMed:25625822, ECO:0000269|PubMed:30100914, ECO:0000269|PubMed:30680886, ECO:0000305|PubMed:30680886}.
|
Penicillium expansum (Blue mold rot fungus)
| 259 |
Cytoplasm, cytosol {ECO:0000269|PubMed:30680886}.
|
MVLTTGLKGAHVLITGGTRGMGEAMVHKFLQEEANVSYCARTVTNTEYDDFYSTLAEGNTARAVGTAFDVASKDSLVKWVESSAERLGRIDVIIANASPMHMEGETEHWESSFAIDVMGFVELVKAATPYLEKSPQASIIVQSSFMGREFYRSPPAAYGPCKAAQLQHVQELSHFLGPKGIRVNAISPGPVLCKGGPWELYSKINPEWVEEQRLKIPLKRLGGPTEVANVAVFLASPLASFVSGTNMLVDGGIHVGTQF
|
[
"GO:0008152",
"GO:0044550",
"GO:1901334",
"GO:1901617",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009987",
"GO:0140723",
"GO:1901362",
"GO:0009058",
"GO:0043385",
"GO:0009404",
"GO:0044237",
"GO:1901360",
"GO:0009403",
"GO:0008150",
"GO:1901576",
"GO:0019748",
"GO:0071704",
"GO:0044283",
"GO:0044281",
"GO:0046165",
"GO:0046483",
"GO:0043386",
"GO:1901336",
"GO:0018130",
"GO:0030639",
"GO:0030638",
"GO:0005737",
"GO:0005829",
"GO:0005575",
"GO:0005622",
"GO:0110165",
"GO:0003824",
"GO:0003674",
"GO:0016491"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0009058",
"GO:0044237",
"GO:0019748",
"GO:0071704",
"GO:0044281",
"GO:0044550",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009404",
"GO:1901360",
"GO:1901576",
"GO:0044283",
"GO:0046483",
"GO:0030638",
"GO:1901334",
"GO:1901617",
"GO:1901362",
"GO:0043385",
"GO:0009403",
"GO:0046165",
"GO:0018130",
"GO:0030639",
"GO:0140723",
"GO:0043386",
"GO:1901336"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016491"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0005737",
"GO:0005829",
"GO:0005622"
] |
[
"IPR036291",
"IPR002347"
] |
af_db/AF-A0A075TRB3-F1-model_v4.cif.gz
|
27334.A0A075TRB3
| null | null |
A0A075TRK9
|
Patulin synthase (EC 1.1.-.-) (Dehydrogenase patE) (Patulin biosynthesis cluster protein E)
|
Patulin synthase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886). PatE catalyzes the last step of the pathway which is the conversion of E-ascladiol to patulin (PubMed:30680886). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable) (PubMed:30680886). {ECO:0000269|PubMed:25625822, ECO:0000269|PubMed:30100914, ECO:0000269|PubMed:30680886, ECO:0000305|PubMed:30680886}.
|
Penicillium expansum (Blue mold rot fungus)
| 628 |
Cytoplasm, cell cortex {ECO:0000269|PubMed:30680886}. Vacuole {ECO:0000269|PubMed:30680886}. Secreted {ECO:0000269|PubMed:30680886}. Secreted, cell wall {ECO:0000269|PubMed:30680886}.
|
MRLTSGIFHAAIAVAAVGAVLPEGPSSSKTHRNEYARRMLGSSFGIPKNQTFDYLVIGGGTAGLTIATRLAEQGVGSVAVIEAGGFYELNNGNLSQIPAQDAFYVGTDLDDWQPGIDWGFHTTPQAGAYDRVSHYARGKCLGGSSARNYMAYQRGTKAAHQRWADTVGDSSYTWEQFLPFFEKSLHFTPANDALRGANASVVSDPSVLGNGDGPLSVTYPHYAQAFATWAKHAFIEIGLQIRSGFQSGALLGQSYGLYTINATTMHRESSETSFLRKGLADPNLTVFQSALAKRIRFQDKRAVGVDVETMGRAYTLSARKEIVLSAGAFQSPQLLMVSGVGPAATLKAHNIPLVADRPGVGQNMQDHIIYAPSYRVNVITQSALLNEEFEAQANRDYNERAAGIYANPTSDILAWEKIPEPKRSAWFSNHTRQVLAEYPDDWPEVEFLTMGGYFGYQRNYIRDNPSDGYNYASLAVSLCTPRSRGNVTITSPDAGVPPVINPNWLTDPVDVELAVAAFKRTRDFFNTTAIKPILIGPEYFPGSQVATDAEILDHVRKSFDTIFHASCTCAMGLANDTQAVVDSKARVIGVEALRVVDASALPFLPPGHPQSTLYALAEKIACEISGNC
|
[
"GO:0008152",
"GO:0044550",
"GO:1901334",
"GO:1901617",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009987",
"GO:0140723",
"GO:1901362",
"GO:0009058",
"GO:0043385",
"GO:0009404",
"GO:0044237",
"GO:1901360",
"GO:0009403",
"GO:0008150",
"GO:1901576",
"GO:0019748",
"GO:0071704",
"GO:0044283",
"GO:0044281",
"GO:0046165",
"GO:0046483",
"GO:0043386",
"GO:1901336",
"GO:0018130",
"GO:0030639",
"GO:0030638",
"GO:0071944",
"GO:0005575",
"GO:0030312",
"GO:0110165",
"GO:0031012",
"GO:0003824",
"GO:0003674",
"GO:0016491"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0009058",
"GO:0044237",
"GO:0019748",
"GO:0071704",
"GO:0044281",
"GO:0044550",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009404",
"GO:1901360",
"GO:1901576",
"GO:0044283",
"GO:0046483",
"GO:0030638",
"GO:1901334",
"GO:1901617",
"GO:1901362",
"GO:0043385",
"GO:0009403",
"GO:0046165",
"GO:0018130",
"GO:0030639",
"GO:0140723",
"GO:0043386",
"GO:1901336"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016491"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0071944",
"GO:0030312",
"GO:0031012"
] |
[
"IPR036188",
"IPR012132",
"IPR000172",
"IPR007867"
] |
pdb_files/8BXL.pdb.gz
|
27334.A0A075TRK9
|
[
"27334.A0A0A2ITX1",
"27334.A0A0A2IEP4",
"27334.A0A0A2LA08",
"27334.A0A0A2IVG3"
] |
[
{
"protein2": "27334.A0A0A2ITX1",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 805,
"textmining": 54,
"combined_score": 807
},
{
"protein2": "27334.A0A0A2IEP4",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 219,
"database": 780,
"textmining": 0,
"combined_score": 820
},
{
"protein2": "27334.A0A0A2LA08",
"neighborhood": 0,
"fusion": 1,
"cooccurence": 0,
"coexpression": 79,
"experimental": 0,
"database": 805,
"textmining": 71,
"combined_score": 818
},
{
"protein2": "27334.A0A0A2IVG3",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 110,
"experimental": 0,
"database": 805,
"textmining": 56,
"combined_score": 821
}
] |
A0A096P8D3
|
Isocitrate dehydrogenase (NAD(+)), mitochondrial (OtIDH) (EC 1.1.1.41)
|
Performs an essential role in the oxidative function of the tricarboxylic acid cycle and respiration (Probable). Catalyzes the decarboxylation of isocitrate to produce 2-oxoglutarate and generate NADH to provide electrons for energy production (Probable). {ECO:0000305|PubMed:25724193}.
|
Ostreococcus tauri
| 470 |
Mitochondrion {ECO:0000255}.
|
MTRVERGRVLARAIERAVAHRASARRWTTTTRTPAWMVTGWMGGRGVDRSTAMTRFERCGSTASSKITAAPMVYVRGEEMTAYVMDLIRSRWIEPRVDVGGWETFDLRAKNRDDTEDRVLRDVIEAGKRIKAIFKEPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGYKKPVLFERHAVGGEYSAGYKNVGKGKLTTTFTPSEGPDAGKTVVVDEREIVDEEAAVVTYHNPYDNVHDLARFFFGRCLEAKVTPYVVTKKTVFKWQEPFWQIMRTVFDEEFKAQFVAAGVMKEGEELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQVHKSPGFITSNLVGVHEDGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAMNHAADVHNIDRDRTHAFTTKMRTVIHQLFREGKGTRDLCGPSGLTTEQFIDAVAERLDA
|
[
"GO:0008152",
"GO:0019752",
"GO:1902652",
"GO:1901615",
"GO:0006102",
"GO:0006753",
"GO:0044237",
"GO:1901360",
"GO:0008150",
"GO:1901564",
"GO:0009117",
"GO:0006139",
"GO:0044281",
"GO:0046496",
"GO:0019362",
"GO:0043436",
"GO:0046483",
"GO:0055086",
"GO:0006082",
"GO:0019637",
"GO:0006807",
"GO:0006163",
"GO:0072350",
"GO:0006066",
"GO:0009987",
"GO:0006725",
"GO:0006796",
"GO:0034641",
"GO:0071704",
"GO:0072521",
"GO:0072524",
"GO:0044238",
"GO:0006793",
"GO:0019674",
"GO:0042803",
"GO:0046983",
"GO:0016616",
"GO:0042802",
"GO:0005488",
"GO:0043169",
"GO:0003824",
"GO:0000287",
"GO:0004448",
"GO:0043167",
"GO:0016614",
"GO:0003674",
"GO:0046872",
"GO:0005515",
"GO:0004449",
"GO:0016491"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0044237",
"GO:0044281",
"GO:0006807",
"GO:0071704",
"GO:0044238",
"GO:1901615",
"GO:1901360",
"GO:1901564",
"GO:0006139",
"GO:0046483",
"GO:0055086",
"GO:0006082",
"GO:0019637",
"GO:0006066",
"GO:0006725",
"GO:0034641",
"GO:0006793",
"GO:1902652",
"GO:0006753",
"GO:0043436",
"GO:0006796",
"GO:0072521",
"GO:0072524",
"GO:0019752",
"GO:0006102",
"GO:0009117",
"GO:0019362",
"GO:0006163",
"GO:0046496",
"GO:0072350",
"GO:0019674"
] |
[
"GO:0003674",
"GO:0005488",
"GO:0003824",
"GO:0043167",
"GO:0005515",
"GO:0016491",
"GO:0046983",
"GO:0042802",
"GO:0043169",
"GO:0016614",
"GO:0042803",
"GO:0016616",
"GO:0046872",
"GO:0000287",
"GO:0004448",
"GO:0004449"
] | null |
[
"IPR004790",
"IPR024084"
] |
pdb_files/6IXL.pdb.gz
|
70448.A0A096P8D3
|
[
"70448.A0A090M5C1",
"70448.Q013V1",
"70448.Q00T57",
"70448.A0A096P9A2",
"70448.A0A090M9S6",
"70448.Q019J3",
"70448.A0A090M8K3",
"70448.Q01GH2",
"70448.A0A090MED5",
"70448.A0A090MC80",
"70448.A0A090M5H0",
"70448.A0A090LZV8",
"70448.Q00ZW8",
"70448.Q00UU5",
"70448.A0A096P9T7",
"70448.A0A096P8J0",
"70448.A0A090N3I9",
"70448.A0A090M837",
"70448.A0A096P768",
"70448.Q01BS2",
"70448.Q0P3H2",
"70448.A0A090N3M1",
"70448.A0A096PB49",
"70448.A0A090MBL3",
"70448.A0A090N391",
"70448.A0A090M353"
] |
[
{
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{
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{
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{
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{
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{
"protein2": "70448.Q019J3",
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"textmining": 623,
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{
"protein2": "70448.A0A090M8K3",
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{
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{
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{
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{
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"textmining": 615,
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{
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"textmining": 615,
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},
{
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{
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"textmining": 615,
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{
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"coexpression": 737,
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"textmining": 615,
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{
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{
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"textmining": 459,
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{
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"coexpression": 227,
"experimental": 120,
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"textmining": 615,
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},
{
"protein2": "70448.A0A096P768",
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"textmining": 330,
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{
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"textmining": 615,
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{
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"coexpression": 792,
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"textmining": 110,
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{
"protein2": "70448.A0A090N3M1",
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{
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{
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{
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{
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}
] |
A0A009IHW8
|
2' cyclic ADP-D-ribose synthase AbTIR (2'cADPR synthase AbTIR) (EC 3.2.2.-) (NAD(+) hydrolase AbTIR) (EC 3.2.2.6) (TIR domain-containing protein in A.baumannii) (AbTIR)
|
NAD(+) hydrolase (NADase) that catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide (PubMed:29395922). In addition to ADPR, also generates a cyclization variant of cyclic ADPR (cADPR), termed 2'cADPR (v-cADPR) (PubMed:29395922, PubMed:36048923). Cleaves NADP(+), but does not cyclize the product (PubMed:36048923). {ECO:0000269|PubMed:29395922, ECO:0000269|PubMed:36048923}.
|
Acinetobacter baumannii (strain 1295743)
| 269 | null |
MSLEQKKGADIISKILQIQNSIGKTTSPSTLKTKLSEISRKEQENARIQSKLSDLQKKKIDIDNKLLKEKQNLIKEEILERKKLEVLTKKQQKDEIEHQKKLKREIDAIKASTQYITDVSISSYNNTIPETEPEYDLFISHASEDKEDFVRPLAETLQQLGVNVWYDEFTLKVGDSLRQKIDSGLRNSKYGTVVLSTDFIKKDWTNYELDGLVAREMNGHKMILPIWHKITKNDVLDYSPNLADKVALNTSVNSIEEIAHQLADVILNR
|
[
"GO:0008152",
"GO:0034655",
"GO:0072523",
"GO:0044270",
"GO:0006753",
"GO:1901292",
"GO:0044237",
"GO:1901360",
"GO:0008150",
"GO:1901564",
"GO:1901565",
"GO:0009117",
"GO:0006139",
"GO:0044281",
"GO:0046496",
"GO:0019362",
"GO:0046483",
"GO:0055086",
"GO:0044248",
"GO:0019439",
"GO:0019637",
"GO:0006807",
"GO:0019677",
"GO:1901361",
"GO:0006163",
"GO:0046700",
"GO:0009987",
"GO:0006725",
"GO:0006796",
"GO:0034641",
"GO:0072521",
"GO:0071704",
"GO:0019364",
"GO:1901575",
"GO:0072526",
"GO:0046434",
"GO:0009166",
"GO:0072524",
"GO:0006195",
"GO:0009056",
"GO:0044238",
"GO:0006793",
"GO:0019674",
"GO:0003674",
"GO:0003953",
"GO:0016787",
"GO:0016799",
"GO:0016798",
"GO:0003824"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0044237",
"GO:0044281",
"GO:0006807",
"GO:0071704",
"GO:0009056",
"GO:0044238",
"GO:1901360",
"GO:1901564",
"GO:0006139",
"GO:0046483",
"GO:0055086",
"GO:0044248",
"GO:0019637",
"GO:0006725",
"GO:0034641",
"GO:1901575",
"GO:0006793",
"GO:0034655",
"GO:0044270",
"GO:0006753",
"GO:1901565",
"GO:0019439",
"GO:1901361",
"GO:0046700",
"GO:0006796",
"GO:0072521",
"GO:0046434",
"GO:0072524",
"GO:0072523",
"GO:1901292",
"GO:0009117",
"GO:0019362",
"GO:0006163",
"GO:0072526",
"GO:0046496",
"GO:0019364",
"GO:0009166",
"GO:0006195",
"GO:0019674",
"GO:0019677"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016787",
"GO:0016798",
"GO:0016799",
"GO:0003953"
] | null |
[
"IPR000157",
"IPR035897"
] |
pdb_files/7UWG.pdb.gz
| null | null | null |
A0A060A682
|
Hapless 2 (Generative cell specific-1)
|
During fertilization, required for the formation of intercellular membrane pores and subsequent exchange of gametic pronuclei between cells. Probably initiates the formation of intercellular membrane pores by inserting part of its extracellular domain into the cell membrane of the adjoining cell in the mating pair. Mating requires the presence of HAP2 on at least one of the two cells. Mating efficiency is high when HAP2 is present on both cells, and is strongly reduced when HAP2 is present on only one of the two cells. {ECO:0000269|PubMed:25155508, ECO:0000269|PubMed:28238660}.
|
Tetrahymena thermophila
| 742 |
Cell membrane {ECO:0000305|PubMed:25155508, ECO:0000305|PubMed:28238660}; Single-pass type I membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:25155508, ECO:0000269|PubMed:28238660}. Note=Detected at the mating junction. {ECO:0000269|PubMed:25155508, ECO:0000269|PubMed:28238660}.
|
MKFLAFGLIYFHFCILNRCEYITSSTIQKCYNSSNEPNNCSQKAVIVLSLENGQIANTEQVVATLNQLSDSGVNKQLQNSFIFEVTKSPVTALFPLIYLQDFNSQPLEQVIATTLFSCKDGFYDSSPTCKFQYDSKGQKILDSQGYCCYCSLSDILGMGNDLSRGKVCYALNLGAGSATAHCLKFSPLWYSAFKIQQYQLYFEVNINIYTVDSQNQKNLKQTLKLSTSNPTMKSSDNSTISKIIGTFTPTQPPADLSSYYLVKPSFPATDPRVLQGISSWMFVDKTMFTLDGTQCNKIGVSYSGFRQQSSSCSQPVGSCLQNQLENLYQSDLILLSQNKQPKYLLESQGNFNQVQFQGQTILQQGLSGSASTLITIEIDAAQIKFVTNLGIGCISQCSINNFESHSGNGKLVALVQNQGNYSAEFVLGFNCSSNVQPIQGQKLFLTANQLYNFNCSVSVNSDISAINNNCTINLYDAIGNQLDSKNILFNTTSTNHTSNQGNNTGQQQSSQEYKSSQSCSDKCSSFWSFWCYFSAGCIKEAFKSIASIAGVASALALVIFLAKNGYLVPIIRFLCCCCCKSKKKENEKNKDKTDKKSIQESCSYDRSCCSHSISQSYQVENKNKYKRSKIQRSFSSESCQDKSKKIINELSNLEETFEANKLYANIDKNSSIFEYFGFKKSFTFILYERNDILFLPQNSTILDMIGALQPQKGSYLAQKFLEIVNKNALKVVSTSPLYLLIE
|
[
"GO:0061025",
"GO:0019953",
"GO:0007009",
"GO:0009987",
"GO:0016043",
"GO:0010256",
"GO:0071840",
"GO:0007338",
"GO:0000003",
"GO:0009566",
"GO:0008150",
"GO:0061024",
"GO:0045026",
"GO:0022414",
"GO:0005575",
"GO:0110165",
"GO:0030054",
"GO:0070161",
"GO:0005911",
"GO:0140522",
"GO:0003674"
] |
[
"GO:0008150",
"GO:0009987",
"GO:0000003",
"GO:0022414",
"GO:0019953",
"GO:0071840",
"GO:0009566",
"GO:0016043",
"GO:0007338",
"GO:0010256",
"GO:0061024",
"GO:0061025",
"GO:0007009",
"GO:0045026"
] |
[
"GO:0003674",
"GO:0140522"
] |
[
"GO:0005575",
"GO:0110165",
"GO:0030054",
"GO:0070161",
"GO:0005911"
] |
[
"IPR040326",
"IPR018928"
] |
af_db/AF-A0A060A682-F1-model_v4.cif.gz
| null | null | null |
A0A061I403
|
Protein adenylyltransferase FICD (EC 2.7.7.108) (AMPylator FICD) (De-AMPylase FICD) (EC 3.1.4.-) (FIC domain-containing protein) (Huntingtin-interacting protein E)
|
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (PubMed:27918543). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (PubMed:27918543). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:27918543). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (PubMed:26673894, PubMed:27918543, PubMed:29064368). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (PubMed:27918543). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (By similarity). {ECO:0000250|UniProtKB:Q9BVA6, ECO:0000269|PubMed:26673894, ECO:0000269|PubMed:27918543, ECO:0000269|PubMed:29064368}.
|
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 455 |
Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BVA6}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9BVA6}.
|
MPMASVIAVAEPKWISVWGRFLWLTLLSMALGSLLALLLPLGAVEEQCLAVLRSFHLLRSKLDRTQHVVTKCTSPSTELSVTSGDVGLLTVKTKTSPAGKLEAKAALNQALEMKRQGKREKAHKLFLHALKMDPGFVDALNEFGIFSEEEKDIIQADYLYTRALTISPFHEKALVNRDRTLPLVEEIDQRYFSIIDSKVKKVMSIPKGSSALRRVMEETYYHHIYHTVAIEGNTLTLSEIRHILETRYAVPGKSLEEQNEVIGMHAAMKYINTTLVSRIGSVTIDDMLEIHRRVLGYVDPVEAGRFRRTQVLVGHHIPPHPRDVEKQMQEFTQWLNSEDAMNLHPVEFAALAHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPITILKEQRSEYYHVLEVANEGDVRPFIRFIAKCTEVTLDTLLLATTEYSVALPEAQPNHSGLKETLPVRP
|
[
"GO:0048583",
"GO:0008152",
"GO:1903894",
"GO:0036211",
"GO:0044601",
"GO:0023051",
"GO:0018175",
"GO:0065007",
"GO:0018117",
"GO:0043412",
"GO:0008150",
"GO:1901564",
"GO:1900101",
"GO:0019538",
"GO:0071704",
"GO:0044602",
"GO:0050789",
"GO:0043170",
"GO:0010646",
"GO:0080134",
"GO:1905897",
"GO:0044238",
"GO:0006807",
"GO:0080135",
"GO:0050794",
"GO:0009966",
"GO:0044603",
"GO:0005488",
"GO:0003824",
"GO:0031072",
"GO:0016788",
"GO:0016740",
"GO:0016787",
"GO:0051087",
"GO:0016772",
"GO:0016779",
"GO:0008081",
"GO:0042578",
"GO:0070733",
"GO:0030544",
"GO:0003674",
"GO:0140096",
"GO:0070566",
"GO:0005515"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0065007",
"GO:0050789",
"GO:0048583",
"GO:0023051",
"GO:0071704",
"GO:0044238",
"GO:0006807",
"GO:0050794",
"GO:1901564",
"GO:0019538",
"GO:0043170",
"GO:0010646",
"GO:0080134",
"GO:0080135",
"GO:0009966",
"GO:0036211",
"GO:0043412",
"GO:1900101",
"GO:1905897",
"GO:1903894",
"GO:0044601",
"GO:0018175",
"GO:0018117",
"GO:0044602"
] |
[
"GO:0003674",
"GO:0005488",
"GO:0003824",
"GO:0016740",
"GO:0016787",
"GO:0140096",
"GO:0005515",
"GO:0044603",
"GO:0031072",
"GO:0016788",
"GO:0051087",
"GO:0016772",
"GO:0016779",
"GO:0042578",
"GO:0030544",
"GO:0008081",
"GO:0070566",
"GO:0070733"
] | null |
[
"IPR003812",
"IPR036597",
"IPR040198",
"IPR011990"
] |
af_db/AF-A0A061I403-F1-model_v4.cif.gz
|
10029.A0A061I403
|
[
"10029.G3GZL0",
"10029.G3I8R9"
] |
[
{
"protein2": "10029.G3GZL0",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 801,
"database": 0,
"textmining": 95,
"combined_score": 812
},
{
"protein2": "10029.G3I8R9",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 860,
"database": 0,
"textmining": 121,
"combined_score": 871
}
] |
A0A067XR63
|
Xyloglucan endotransglucosylase protein 7 (XET protein 7) (EC 2.4.1.207) (DkXTH7) (Xyloglucan endotransglucosylase/hydrolase protein 7) (XTH protein 7)
|
Catalyzes xyloglucan endotransglycosylation (XET). Cleaves and religates xyloglucan polymers. Does not catalyze xyloglucan endohydrolysis (XEH). Probably involved in cell wall assembly and synthesis in fast growing tissues and in the maintenance of firmness in mature fruits. {ECO:0000269|PubMed:27242828}.
|
Diospyros kaki (Kaki persimmon) (Diospyros chinensis)
| 268 |
Cytoplasm {ECO:0000269|PubMed:27242828}. Note=Dispersed throughout the cell. {ECO:0000269|PubMed:27242828}.
|
MNAEGGNLHREFEITWGDGRARIHNNGGLLTLSLDRASGSGFRSKNEYLFGRIEIQIKLVAGNSAGTVATYYLSSEGPTHDEIDFEFLGNSSGEPYTLHTNVFSQGKGNREQQFFLWFDPTMDFHTYTILWNPQRIIFYVDETPIREFKNLERHGIPFPRSQAMRVYSSMWNADDWATRGGLVKTDWTKAPFTASYRSYKADACVWSGEASSCGSQDSNPSDKWWMTEELNATRMKRLRWVQKKYMVYNYCVDKMRFPEGLAPECNIS
|
[
"GO:0045229",
"GO:0071555",
"GO:0042546",
"GO:0009987",
"GO:0016043",
"GO:0070726",
"GO:0071840",
"GO:0071554",
"GO:0008150",
"GO:0044085",
"GO:0022607",
"GO:0046527",
"GO:0016740",
"GO:0003674",
"GO:0016762",
"GO:0003824",
"GO:0016757",
"GO:0016758"
] |
[
"GO:0008150",
"GO:0009987",
"GO:0071840",
"GO:0071554",
"GO:0071555",
"GO:0042546",
"GO:0016043",
"GO:0044085",
"GO:0045229",
"GO:0070726",
"GO:0022607"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016740",
"GO:0016757",
"GO:0016758",
"GO:0046527",
"GO:0016762"
] | null |
[
"IPR044791",
"IPR008264",
"IPR013320",
"IPR000757",
"IPR008263",
"IPR010713",
"IPR016455"
] |
af_db/AF-A0A067XR63-F1-model_v4.cif.gz
| null | null | null |
A0A067YMX8
|
Xyloglucan endotransglucosylase protein 8 (XET protein 8) (EC 2.4.1.207) (DkXTH8) (Xyloglucan endotransglucosylase/hydrolase protein 8) (XTH protein 8)
|
Catalyzes xyloglucan endotransglycosylation (XET). Cleaves and religates xyloglucan polymers. Does not catalyze xyloglucan endohydrolysis (XEH). Overexpression in Arabidopsis transgenic plants causes accelerated dark-induced leaf senescence and higher lipid peroxidation of the leaf cells. Overexpression in transgenic tomato plants promotes fruit ripening and softening. Probably involved in cell wall restructuring during postharvest fruit softening. {ECO:0000269|PubMed:27966647}.
|
Diospyros kaki (Kaki persimmon) (Diospyros chinensis)
| 288 |
Secreted, cell wall {ECO:0000255|RuleBase:RU361120, ECO:0000269|PubMed:27966647}. Secreted, extracellular space, apoplast {ECO:0000255|RuleBase:RU361120}.
|
MAASPYSIFAVQLLLLASWMLSSSSSNFNQDFNIAWGGGRARILNNGELVTLSLDKASGSGFRSKNLYLFGKIDMQLKLVPGNSAGTVTTYYLSSEGSVRDEIDFEFLGNLTGEPYTLHTNVYSHGKGEREQQFRLWFDPAADFHTYSILWNSKTIVFYVDQTPVREFKNMESIGVPYLRQPMRLFSSIWNADEWATRGGLIKTDWTQAPFTTSYRNFRADNACVWAAKASSCGLAAGGNAWLSVELDAKSRGRLRWVRRNQMIYDYCVDGKRFPRGVPPECKLNLHI
|
[
"GO:0008152",
"GO:0009835",
"GO:0009739",
"GO:0048856",
"GO:0061458",
"GO:0009057",
"GO:0071370",
"GO:0000272",
"GO:0007275",
"GO:0044036",
"GO:0097305",
"GO:0032870",
"GO:0044347",
"GO:0044237",
"GO:0008150",
"GO:0042221",
"GO:0016998",
"GO:0050896",
"GO:0071310",
"GO:0071396",
"GO:0033993",
"GO:0071554",
"GO:0070887",
"GO:0044265",
"GO:0009719",
"GO:0044042",
"GO:0044248",
"GO:0048731",
"GO:0044264",
"GO:0005976",
"GO:2000895",
"GO:0022414",
"GO:0051716",
"GO:0032502",
"GO:0071495",
"GO:0009987",
"GO:0016043",
"GO:0048608",
"GO:0071840",
"GO:1901700",
"GO:0010383",
"GO:0021700",
"GO:0005975",
"GO:2000899",
"GO:0009737",
"GO:0010411",
"GO:0009251",
"GO:0045229",
"GO:0071704",
"GO:1901575",
"GO:0071555",
"GO:0016052",
"GO:0003006",
"GO:0044260",
"GO:0043170",
"GO:0044262",
"GO:0010033",
"GO:1901701",
"GO:0009725",
"GO:0009056",
"GO:0000003",
"GO:0010154",
"GO:0032501",
"GO:0010410",
"GO:0044238",
"GO:0006073",
"GO:0071695",
"GO:0046527",
"GO:0016740",
"GO:0003674",
"GO:0016762",
"GO:0003824",
"GO:0016757",
"GO:0016758"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0050896",
"GO:0022414",
"GO:0032502",
"GO:0009987",
"GO:0000003",
"GO:0032501",
"GO:0048856",
"GO:0007275",
"GO:0044237",
"GO:0042221",
"GO:0071554",
"GO:0009719",
"GO:0051716",
"GO:0071840",
"GO:0021700",
"GO:0071704",
"GO:0003006",
"GO:0009056",
"GO:0044238",
"GO:0009835",
"GO:0044036",
"GO:0070887",
"GO:0044248",
"GO:0048731",
"GO:0071495",
"GO:0016043",
"GO:0048608",
"GO:1901700",
"GO:0005975",
"GO:1901575",
"GO:0071555",
"GO:0044260",
"GO:0043170",
"GO:0044262",
"GO:0010033",
"GO:0009725",
"GO:0071695",
"GO:0009739",
"GO:0061458",
"GO:0009057",
"GO:0097305",
"GO:0032870",
"GO:0016998",
"GO:0071310",
"GO:0033993",
"GO:0044265",
"GO:0044264",
"GO:0005976",
"GO:0010383",
"GO:0009737",
"GO:0045229",
"GO:0016052",
"GO:1901701",
"GO:0010154",
"GO:0071370",
"GO:0000272",
"GO:0044347",
"GO:0071396",
"GO:0044042",
"GO:0010410",
"GO:0006073",
"GO:2000895",
"GO:0010411",
"GO:0009251",
"GO:2000899"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016740",
"GO:0016757",
"GO:0016758",
"GO:0046527",
"GO:0016762"
] | null |
[
"IPR044791",
"IPR013320",
"IPR000757",
"IPR008263",
"IPR010713",
"IPR016455"
] |
af_db/AF-A0A067YMX8-F1-model_v4.cif.gz
| null | null | null |
A0A095AMW7
|
Malolactic enzyme (MLE) (EC 4.1.1.101)
|
Involved in the malolactic fermentation (MLF) of wine, which results in a natural decrease in acidity and favorable changes in wine flavors. Catalyzes the decarboxylation of L-malate to L-lactate. {ECO:0000269|PubMed:16345941}.
|
Leuconostoc mesenteroides
| 542 | null |
MNTTGYDILRNPFLNKGTAFSEAERQQLGLTGTLPSQIQTIEEQAEQAYKQFQAKSPLLEKRIFLMNLFNENVTLFYHLMDQHVSEFMPIVYDPVVAESIEQYNEIYTNPQNAAFLSVDRPEDVENALKNAAAGRDIKLVVVTDAEGILGMGDWGVNGVDIAVGKLMVYTAAAGIDPATVLPVSIDAGTNNKELLHNPLYLGNKHERIAGEQYLEFIDKFVTAEQNLFPESLLHWEDFGRSNAQVILDKYKESIATFNDDIQGTGMIVLAGIFGALNISKQKLVDQKFVTFGAGTAGMGIVNQIFSELKQAGLSDDEARNHFYLVDKQGLLFDDTEGLTAAQKPFTRSRKEFVNPEQLINLETIVKELHPTVLIGTSTQPGTFTETIVKSMAENTERPIIFPLSNPTKLAEATAEDLIKWTGGKALVATGIPAADVDYKGVTYKIGQGNNALIYPGLGFGLVASTAKLLTQETISAAIHALGGLVDTDEPGAAVLPPVSNLTDFSQKIAEITAQSVVNQGLNREKIVDPKQAVQDAKWSAEY
|
[
"GO:0008152",
"GO:0015980",
"GO:0009987",
"GO:0006091",
"GO:0008150",
"GO:0044237",
"GO:0006113",
"GO:0043464",
"GO:0016830",
"GO:0005488",
"GO:0036094",
"GO:0003824",
"GO:1901363",
"GO:1901265",
"GO:0046914",
"GO:0000166",
"GO:0043169",
"GO:0030145",
"GO:0097159",
"GO:0043167",
"GO:0003674",
"GO:0016831",
"GO:0046872",
"GO:0017076",
"GO:0051287",
"GO:0016829",
"GO:0030554"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0044237",
"GO:0006091",
"GO:0015980",
"GO:0006113",
"GO:0043464"
] |
[
"GO:0003674",
"GO:0005488",
"GO:0003824",
"GO:0036094",
"GO:1901363",
"GO:0097159",
"GO:0043167",
"GO:0016829",
"GO:0016830",
"GO:1901265",
"GO:0000166",
"GO:0043169",
"GO:0016831",
"GO:0046872",
"GO:0017076",
"GO:0046914",
"GO:0030554",
"GO:0030145",
"GO:0051287"
] | null |
[
"IPR046346",
"IPR015884",
"IPR012301",
"IPR037062",
"IPR012302",
"IPR001891",
"IPR048182",
"IPR036291"
] |
af_db/AF-A0A095AMW7-F1-model_v4.cif.gz
| null | null | null |
A0A0A1H8I4
|
Aconitate isomerase (AI) (EC 5.3.3.7)
|
Involved in assimilation of trans-aconitic acid. Preference for cis-aconitic acid is 14-fold higher than for trans-aconitic acid. Not active on intermediates of tricarboxylic acid (TCA) cycle including citric acid, succinic acid, fumaric acid, and 2-oxoglutaric acid or on other dicarboxilic acids including itaconic acid, formic acid, citraconic acid or maleic acid. {ECO:0000269|PubMed:26293748}.
|
Pseudomonas sp
| 262 | null |
MFPRLPTLALGALLLASTPLLAAQPVTTLTVLSSGGIMGTIREVAPAYEKATGVKLDIAAAPSMGDTPQAIPNRLARNEPADVVLMVGSALDKLVASGQVAKDSRVDLGQSFIAMAVRQGAPKPDISNMDAFKQTLEKAQSVAYSDSASGVYLSRILFPRMQLDKSFMAKARMIPAEPVGAVVARGEAQLGFQQLSELKAVPGIDIVGLIPDQAQKMTLYSGAMVSKSQHPEAARALLQYLASKDAAKAIEDSGLKPVPAQP
|
[
"GO:0010038",
"GO:0071248",
"GO:0051592",
"GO:0010035",
"GO:0010045",
"GO:0008150",
"GO:0042221",
"GO:0071292",
"GO:0046689",
"GO:0071287",
"GO:0071241",
"GO:0050896",
"GO:0017085",
"GO:0070887",
"GO:0010039",
"GO:1902075",
"GO:0009636",
"GO:0010272",
"GO:0071277",
"GO:0051716",
"GO:0032026",
"GO:0046680",
"GO:0009987",
"GO:1901700",
"GO:0071286",
"GO:0014070",
"GO:0071289",
"GO:0010033",
"GO:1901701",
"GO:0010042",
"GO:0071281",
"GO:1902074",
"GO:0016853",
"GO:0003674",
"GO:0016860",
"GO:0047614",
"GO:0003824",
"GO:0016863"
] |
[
"GO:0008150",
"GO:0050896",
"GO:0009987",
"GO:0042221",
"GO:0051716",
"GO:0010035",
"GO:0070887",
"GO:0009636",
"GO:1901700",
"GO:0010033",
"GO:1902074",
"GO:0010038",
"GO:0051592",
"GO:0071241",
"GO:0017085",
"GO:1902075",
"GO:0014070",
"GO:1901701",
"GO:0071248",
"GO:0010045",
"GO:0046689",
"GO:0010039",
"GO:0010272",
"GO:0071277",
"GO:0032026",
"GO:0046680",
"GO:0010042",
"GO:0071292",
"GO:0071287",
"GO:0071286",
"GO:0071289",
"GO:0071281"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016853",
"GO:0016860",
"GO:0016863",
"GO:0047614"
] | null |
[
"IPR050682"
] |
af_db/AF-A0A0A1H8I4-F1-model_v4.cif.gz
| null | null | null |
A0A0A6ZFY4
|
UDP-glucosyltransferase 29 (UGTPg29) (EC 2.4.1.365) (UDP-glucosyltransferase 94B1) (PgUGT94B1) (UDP-glucosyltransferase 94Q2) (PgUGT94Q2)
|
Component of the dammarane-type triterpene saponins (e.g. PPD-type ginsenosides or panaxosides) biosynthetic pathway (PubMed:25320211, PubMed:25769286, PubMed:27746309, PubMed:29378087). Glycosyltransferase that catalyzes the conversion of ginsenoside Rh2 to ginsenoside Rg3 (PubMed:25320211, PubMed:25769286, PubMed:27746309). Triggers the biosynthesis of ginsenoside Rd from ginsenoside F2 (PubMed:25320211). {ECO:0000269|PubMed:25320211, ECO:0000269|PubMed:25769286, ECO:0000269|PubMed:27746309, ECO:0000303|PubMed:29378087}.
|
Panax ginseng (Korean ginseng)
| 442 | null |
MDNQNGRISIALLPFLAHGHISPFFELAKQLAKRNCNVFLCSTPINLSSIKDKDSSASIKLVELHLPSSPDLPPHYHTTNGLPSHLMLPLRNAFETAGPTFSEILKTLNPDLLIYDFNPSWAPEIASSHNIPAVYFLTTAAASSSIGLHAFKNPGEKYPFPDFYDNSNITPEPPSADNMKLLHDFIACFERSCDIILIKSFRELEGKYIDLLSTLSDKTLVPVGPLVQDPMGHNEDPKTEQIINWLDKRAESTVVFVCFGSEYFLSNEELEEVAIGLEISTVNFIWAVRLIEGEKKGILPEGFVQRVGDRGLVVEGWAPQARILGHSSTGGFVSHCGWSSIAESMKFGVPVIAMARHLDQPLNGKLAAEVGVGMEVVRDENGKYKREGIAEVIRKVVVEKSGEVIRRKARELSEKMKEKGEQEIDRALEELVQICKKKKDEQ
|
[
"GO:0008152",
"GO:0009605",
"GO:0002238",
"GO:0120252",
"GO:0009058",
"GO:1901659",
"GO:0044237",
"GO:0008150",
"GO:1901576",
"GO:0042221",
"GO:0006720",
"GO:0043207",
"GO:0006629",
"GO:0050896",
"GO:0120251",
"GO:0009607",
"GO:0016137",
"GO:0044419",
"GO:0044255",
"GO:0044249",
"GO:0009987",
"GO:1901657",
"GO:0042214",
"GO:0071704",
"GO:1901137",
"GO:0016135",
"GO:0016138",
"GO:0010033",
"GO:0008299",
"GO:1901135",
"GO:0009620",
"GO:0051707",
"GO:0008610",
"GO:0046246",
"GO:0044238",
"GO:0016134",
"GO:0008194",
"GO:0016740",
"GO:0003674",
"GO:0003824",
"GO:0016757"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0050896",
"GO:0044419",
"GO:0009987",
"GO:0009605",
"GO:0009058",
"GO:0044237",
"GO:0042221",
"GO:0009607",
"GO:0071704",
"GO:0051707",
"GO:0044238",
"GO:0120252",
"GO:1901576",
"GO:0043207",
"GO:0006629",
"GO:0044255",
"GO:0044249",
"GO:0010033",
"GO:1901135",
"GO:0009620",
"GO:0002238",
"GO:0006720",
"GO:0120251",
"GO:1901657",
"GO:0042214",
"GO:1901137",
"GO:0008299",
"GO:0008610",
"GO:1901659",
"GO:0016137",
"GO:0046246",
"GO:0016138",
"GO:0016134",
"GO:0016135"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016740",
"GO:0016757",
"GO:0008194"
] | null |
[
"IPR002213",
"IPR035595"
] |
af_db/AF-A0A0A6ZFY4-F1-model_v4.cif.gz
| null | null | null |
A0A072VDF2
|
Cinnamoyl-CoA reductase 1 (Mt-CCR1) (EC 1.2.1.44) (Caffeoyl-CoA reductase) (EC 1.2.1.-) (Coumaroyl-CoA reductase) (Feruloyl-CoA reductase) (Sinapoyl-CoA reductase)
|
Involved in the latter stages of lignin biosynthesis (PubMed:20876124). Catalyzes one of the last steps of monolignol biosynthesis, the conversion of cinnamoyl-CoAs into their corresponding cinnamaldehydes (PubMed:20876124). Mediates the conversion of feruloyl-CoA to coniferylaldehyde (PubMed:20876124). Also active, with a lower efficiency, toward coumaroyl-CoA, caffeoyl CoA and sinapoyl-CoA (PubMed:20876124). Involved in the production of floral volatile phenylpropanoids in flowers of fragrant cultivars from cinnamic acid, a common precursor with the anthocyanin biosynthesis pathway involved in flower pigmentation (By similarity). {ECO:0000250|UniProtKB:A0A059TC02, ECO:0000269|PubMed:20876124}.
|
Medicago truncatula (Barrel medic) (Medicago tribuloides)
| 342 |
Cytoplasm {ECO:0000250|UniProtKB:A0A059TC02}.
|
MPAATAAAAAESSSVSGETICVTGAGGFIASWMVKLLLEKGYTVRGTLRNPDDPKNGHLKKLEGAKERLTLVKVDLLDLNSVKEAVNGCHGVFHTASPVTDNPEEMVEPAVNGAKNVIIAGAEAKVRRVVFTSSIGAVYMDPNRSVDVEVDESCWSDLEFCKKTKNWYCYGKAVAEAAAWDVAKEKGVDLVVVNPVLVLGPLLQPTINASTIHILKYLTGSAKTYANATQAYVHVRDVALAHILVYEKPSASGRYLCAETSLHRGELVEILAKYFPEYPIPTKCSDEKNPRVKPHIFSNKKLKDLGLEFTPVSECLYETVKSLQDQGHLSIPNKEDSLAVKS
|
[
"GO:0008152",
"GO:0044550",
"GO:0044249",
"GO:0009987",
"GO:1901362",
"GO:0009058",
"GO:0006725",
"GO:0009808",
"GO:0044237",
"GO:1901360",
"GO:0019748",
"GO:0008150",
"GO:1901576",
"GO:0071704",
"GO:0019438",
"GO:0009699",
"GO:0009698",
"GO:0009809",
"GO:0016616",
"GO:0016621",
"GO:0003824",
"GO:0016614",
"GO:0003674",
"GO:0016620",
"GO:0016903",
"GO:0016491"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0009058",
"GO:0044237",
"GO:0019748",
"GO:0071704",
"GO:0044550",
"GO:0044249",
"GO:0006725",
"GO:1901360",
"GO:1901576",
"GO:0009698",
"GO:1901362",
"GO:0009808",
"GO:0019438",
"GO:0009699",
"GO:0009809"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016491",
"GO:0016614",
"GO:0016903",
"GO:0016616",
"GO:0016620",
"GO:0016621"
] | null |
[
"IPR001509",
"IPR036291",
"IPR050425"
] |
af_db/AF-A0A072VDF2-F1-model_v4.cif.gz
|
3880.A0A072VDF2
|
[
"3880.B7FMK4",
"3880.B7FGU9",
"3880.A0A072UNT2",
"3880.G7KYD3",
"3880.A0A072UQL2",
"3880.G7J134",
"3880.A0A072UWU0",
"3880.A0A072U2T1",
"3880.G7J516",
"3880.A0A072TSD5",
"3880.A0A072VLE4",
"3880.G7L0U5",
"3880.A0A072URR0",
"3880.A0A072VD63",
"3880.G7LAJ5",
"3880.G7KNI6",
"3880.G7KL55",
"3880.A0A072TSE6",
"3880.G7IBA9",
"3880.A0A072TRT2",
"3880.A0A072UQF3",
"3880.A0A072VKS8",
"3880.A0A072UT55",
"3880.G7LC30",
"3880.A0A072UGI8",
"3880.G7K877",
"3880.G7J914",
"3880.G7K879",
"3880.I3S2G2",
"3880.G7KMS8",
"3880.G7JPL6",
"3880.G7JJF2",
"3880.A0A072VH10",
"3880.A0A072VPZ8",
"3880.A0A072U2U7",
"3880.A0A072UT24",
"3880.G7K3P1",
"3880.G7ZY18",
"3880.G7I7A7",
"3880.A0A072U4G3",
"3880.G7KJ71",
"3880.G7L8Y6",
"3880.A0A072UJR1",
"3880.I3T4G8",
"3880.G7K6G3",
"3880.B7FGL2",
"3880.G7ZZA6",
"3880.A0A072URQ6",
"3880.A0A072TRT8",
"3880.G7L4Y4",
"3880.G7KNI3",
"3880.G7JA70",
"3880.G7JVI7",
"3880.B7FHM1",
"3880.G7K511",
"3880.G7IML7",
"3880.A0A072VCX9",
"3880.G7JEE5",
"3880.G7JTB1",
"3880.A0A072UP83",
"3880.G7KGC6",
"3880.A0A072UR10",
"3880.I3SV05",
"3880.A0A072VK34",
"3880.G7JK14",
"3880.B7FLW8",
"3880.G7IS81",
"3880.G7K1K2",
"3880.G7L2J4",
"3880.G7IBI3",
"3880.G7I8B8",
"3880.G7LH64",
"3880.A0A072UEC5",
"3880.G7KP51",
"3880.A0A072UQ24",
"3880.A0A072V8V5",
"3880.G7ZYW6",
"3880.G7J515",
"3880.G7JSR6",
"3880.A0A072VL68",
"3880.A0A072UV79",
"3880.G7K0X3",
"3880.I3SHI5",
"3880.G7I515",
"3880.G7K0Q0",
"3880.A0A072TRH8",
"3880.Q2MJ09",
"3880.B7FMB4",
"3880.A0A072VHJ4",
"3880.B7FHE5",
"3880.G7LJL7",
"3880.A0A072VBJ7",
"3880.A0A072URX8",
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"cooccurence": 0,
"coexpression": 276,
"experimental": 425,
"database": 316,
"textmining": 91,
"combined_score": 706
},
{
"protein2": "3880.A0A072URX8",
"neighborhood": 47,
"fusion": 0,
"cooccurence": 0,
"coexpression": 48,
"experimental": 0,
"database": 689,
"textmining": 660,
"combined_score": 891
},
{
"protein2": "3880.G7LIL0",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 78,
"experimental": 0,
"database": 650,
"textmining": 618,
"combined_score": 866
},
{
"protein2": "3880.G7LC37",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 64,
"experimental": 69,
"database": 675,
"textmining": 536,
"combined_score": 850
},
{
"protein2": "3880.G7KRW6",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 0,
"textmining": 804,
"combined_score": 803
},
{
"protein2": "3880.A0A072TEU0",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 78,
"experimental": 0,
"database": 650,
"textmining": 618,
"combined_score": 866
},
{
"protein2": "3880.A0A072VCC0",
"neighborhood": 47,
"fusion": 0,
"cooccurence": 0,
"coexpression": 48,
"experimental": 0,
"database": 689,
"textmining": 668,
"combined_score": 893
},
{
"protein2": "3880.G7KYD1",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 48,
"experimental": 69,
"database": 675,
"textmining": 90,
"combined_score": 702
},
{
"protein2": "3880.A0A072W2N7",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 0,
"experimental": 0,
"database": 0,
"textmining": 845,
"combined_score": 845
},
{
"protein2": "3880.A0A072VH15",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 235,
"experimental": 0,
"database": 650,
"textmining": 634,
"combined_score": 893
},
{
"protein2": "3880.Q2HTB3",
"neighborhood": 0,
"fusion": 0,
"cooccurence": 0,
"coexpression": 78,
"experimental": 0,
"database": 650,
"textmining": 618,
"combined_score": 866
}
] |
A0A075FBG7
|
9,13-epoxylabda-14-ene synthase, chloroplastic (EC 4.2.3.189) (Manoyl oxide synthase) (EC 4.2.3.190) (Miltiradiene synthase) (EC 4.2.3.131)
|
Involved in the biosynthesis of labdane-type diterpenoid including marrubiin and other labdane-related furanoid diterpenoids with potential applications as anti-diabetics, analgesics or vasorelaxants (Probable). Terpene synthase the catalyzes the conversion of peregrinol diphosphate to 9,13(R)-epoxy-labd-14-ene, from (+)-copalyl diphosphate ((+)-CPP) to miltiradiene and from 8-hydroxycopalyl diphosphate (LPP, labda-13-en-8-ol diphosphate) to manoyl oxide (PubMed:24990389). {ECO:0000269|PubMed:24990389, ECO:0000305|PubMed:24990389}.
|
Marrubium vulgare (White horehound)
| 580 |
Plastid, chloroplast {ECO:0000255}.
|
MSITFNLKIAPFSGPGIQRSKETFPATEIQITASTKSTMTTKCSFNASTDFMGKLREKVGGKADKPPVVIHPVDISSNLCMIDTLQSLGVDRYFQSEINTLLEHTYRLWKEKKKNIIFKDVSCCAIAFRLLREKGYQVSSDKLAPFADYRIRDVATILELYRASQARLYEDEHTLEKLHDWSSNLLKQHLLNGSIPDHKLHKQVEYFLKNYHGILDRVAVRRSLDLYNINHHHRIPDVADGFPKEDFLEYSMQDFNICQAQQQEELHQLQRWYADCRLDTLNYGRDVVRIANFLTSAIFGEPEFSDARLAFAKHIILVTRIDDFFDHGGSREESYKILDLVQEWKEKPAEEYGSKEVEILFTAVYNTVNDLAEKAHIEQGRCVKPLLIKLWVEILTSFKKELDSWTEETALTLDEYLSSSWVSIGCRICILNSLQYLGIKLSEEMLSSQECTDLCRHVSSVDRLLNDVQTFKKERLENTINSVGLQLAAHKGERAMTEEDAMSKIKEMADYHRRKLMQIVYKEGTVFPRECKDVFLRVCRIGYYLYSSGDEFTSPQQMKEDMKSLVYQPVKIHPLEAINV
|
[
"GO:0008152",
"GO:0044255",
"GO:0044249",
"GO:0009987",
"GO:0120252",
"GO:1901362",
"GO:0009058",
"GO:0044238",
"GO:0044237",
"GO:1901360",
"GO:0006720",
"GO:1901576",
"GO:0008150",
"GO:1901944",
"GO:0042214",
"GO:0006629",
"GO:0071704",
"GO:0120251",
"GO:0008299",
"GO:0008610",
"GO:0046246",
"GO:1901946",
"GO:0016835",
"GO:0003824",
"GO:0062205",
"GO:0062206",
"GO:0003674",
"GO:0016838",
"GO:0016829",
"GO:0106239"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0009058",
"GO:0044238",
"GO:0044237",
"GO:0071704",
"GO:0044255",
"GO:0044249",
"GO:0120252",
"GO:1901360",
"GO:1901576",
"GO:0006629",
"GO:1901362",
"GO:0006720",
"GO:1901944",
"GO:0042214",
"GO:0120251",
"GO:0008299",
"GO:0008610",
"GO:0046246",
"GO:1901946"
] |
[
"GO:0003674",
"GO:0003824",
"GO:0016829",
"GO:0016835",
"GO:0016838",
"GO:0062205",
"GO:0062206",
"GO:0106239"
] | null |
[
"IPR008949",
"IPR001906",
"IPR036965",
"IPR050148",
"IPR005630",
"IPR008930"
] |
af_db/AF-A0A075FBG7-F1-model_v4.cif.gz
| null | null | null |
A0A075TR41
|
Probable oxidoreductase patJ (EC 1.-.-.-) (Patulin biosynthesis cluster protein J)
|
Probable oxidoreductase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886). PatJ acts with patO in the vacuole to convert gentisyl alcohol to isoepoxydon (PubMed:30680886). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable) (PubMed:30680886). {ECO:0000269|PubMed:25625822, ECO:0000269|PubMed:30100914, ECO:0000269|PubMed:30680886, ECO:0000305|PubMed:30680886}.
|
Penicillium expansum (Blue mold rot fungus)
| 326 |
Vacuole lumen {ECO:0000269|PubMed:30680886}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:30680886}.
|
MAPFVPYHYSAGQSTIVKFGGLLTTEFLEPPPGRCFLFRQTYRHTIEGSIPENLRKLINSPDRPKGPPPHFHQFQTEYFRVENGVLGISVDGVVRRITPEDGEISVKAGSVHNFFIHPDSPENMTVYLSASDSGNDYQLDRVFFENWYGYWHDALLHDGGIDWIQFLAIQDGGDAYTPAPAWVPFRRQVGYWTCVIVGRWIGGLLGYKPFFREYTTDWDFAVAKMKGSFFQRHLVHAAFEEEKSWTKQAELEPKGKPENAEFEPWTEDMSPAPLSLGPVAYEQGLFHGVQPGSVNGSNGHSTGVESKLEQLGSRAQRRVVIDDAGK
|
[
"GO:0008152",
"GO:0044550",
"GO:1901334",
"GO:1901617",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009987",
"GO:0140723",
"GO:1901362",
"GO:0009058",
"GO:0043385",
"GO:0009404",
"GO:0044237",
"GO:1901360",
"GO:0009403",
"GO:0008150",
"GO:1901576",
"GO:0019748",
"GO:0071704",
"GO:0044283",
"GO:0044281",
"GO:0046165",
"GO:0046483",
"GO:0043386",
"GO:1901336",
"GO:0018130",
"GO:0030639",
"GO:0030638",
"GO:0005773",
"GO:0005622",
"GO:0043229",
"GO:0043226",
"GO:0110165",
"GO:0005737",
"GO:0005575",
"GO:0043227",
"GO:0043231"
] |
[
"GO:0008150",
"GO:0008152",
"GO:0009987",
"GO:0009058",
"GO:0044237",
"GO:0019748",
"GO:0071704",
"GO:0044281",
"GO:0044550",
"GO:1901615",
"GO:0006066",
"GO:0044249",
"GO:0009404",
"GO:1901360",
"GO:1901576",
"GO:0044283",
"GO:0046483",
"GO:0030638",
"GO:1901334",
"GO:1901617",
"GO:1901362",
"GO:0043385",
"GO:0009403",
"GO:0046165",
"GO:0018130",
"GO:0030639",
"GO:0140723",
"GO:0043386",
"GO:1901336"
] | null |
[
"GO:0005575",
"GO:0110165",
"GO:0005622",
"GO:0043226",
"GO:0005737",
"GO:0005773",
"GO:0043229",
"GO:0043227",
"GO:0043231"
] |
[
"IPR014710",
"IPR011051"
] |
af_db/AF-A0A075TR41-F1-model_v4.cif.gz
|
27334.A0A075TR41
| null | null |
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