Datasets:

---

siddharthtumre

/

jnlpba-split

like 0

[ "These", "extrathymic", "T-cell", "populations", "include", "cells", "expressing", "elevated", "levels", "of", "V", "beta", "T-cell", "receptors", "that", "are", "normally", "deleted", "in", "thymic", "development", "." ]

[ 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "results", "suggest", "that", "M7", "blasts", "and", "TMD", "blasts", "correspond", "to", "the", "erythroid/megakaryocytic", "bipotential", "progenitor", "cells", "." ]

[ 0, 0, 0, 0, 7, 8, 0, 7, 8, 0, 0, 0, 7, 8, 8, 8, 0 ]

[ "A", "factor", "known", "to", "bind", "to", "endogenous", "Ig", "heavy", "chain", "enhancer", "only", "in", "lymphocytes", "is", "a", "ubiquitously", "active", "transcription", "factor", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 7, 0, 0, 9, 10, 10, 10, 0 ]

[ "Fine", "mapping", "by", "in", "vivo", "footprinting", "demonstrated", "five", "transcription", "factor", "binding", "sites", "that", "are", "occupied", "in", "both", "resting", "and", "activated", "peripheral", "blood", "T", "lymphocytes", ";", "these", "are", "tandem", "CRE", "motifs", ",", "a", "Sp1", "site", ",", "an", "overlapping", "Egr-1/Sp1", "site", ",", "and", "a", "novel", "palindromic", "octamer", "sequence", "(", "POS", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0 ]

[ "Electrophoretic", "mobility", "shift", "analysis", "does", "not", "detect", "a", "direct", "interaction", "of", "the", "CD14", "distal", "Sp1-binding", "site", "with", "the", "vitamin", "D3", "receptor", "and", "its", "partner", ",", "the", "retinoid", "X", "receptor", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 1, 2, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "Expression", "of", "the", "human", "RAR-alpha", "in", "receptor-negative", "erythroblasts", "conferred", "RA-induced", "regulation", "of", "differentiation", "to", "the", "otherwise", "unresponsive", "cells", ",", "thus", "showing", "that", "the", "RAR-alpha", "is", "essential", "for", "the", "RA", "effect", "." ]

[ 0, 0, 0, 9, 10, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "serum", "response", "element", "(", "SRE", ")", "in", "the", "c-fos", "regulatory", "region", "participates", "in", "induction", "of", "transcription", "by", "various", "growth", "factors", "and", "by", "phorbol", "esters", "and", "subsequent", "squelching", "of", "transcription", "." ]

[ 0, 1, 2, 2, 0, 1, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Involvement", "of", "G", "protein", "in", "the", "activation", "of", "MAPK", "pathway", "by", "TCC", "was", "indicated", "by", "inhibition", "of", "Raf-1", "and", "ERK1", "kinase", "activity", ",", "as", "well", "as", "the", "DNA", "synthesis", "by", "pretreatment", "of", "cells", "with", "pertussis", "toxin", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "The", "eosinophilic", "characteristics", "of", "YJ", "cells", "were", "confirmed", "by", "histochemical", "staining", "with", "Fast-Green/Neutral-Red", "and", "by", "the", "expression", "of", "mRNAs", "for", "eosinophil-associated", "granule", "proteins", ",", "eosinophil", "cationic", "protein", "(", "ECP", ")", ",", "eosinophil-derived", "neurotoxin", "(", "EDN", ")", ",", "eosinophil", "peroxidase", "(", "EPO", ")", ",", "and", "major", "basic", "protein", "(", "MBP", ")", ",", "and", "for", "the", "Charcot-Leyden", "crystal", "(", "CLC", ")", "protein", "." ]

[ 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 9, 10, 10, 0, 9, 10, 10, 0, 9, 0, 0, 9, 10, 0, 9, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0 ]

[ "This", "observation", "suggests", "that", "physical", "linkage", "to", "XIC/XIST", "does", "not", "lead", "to", "de", "novo", "inactivation", "of", "autosomal", "material", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "BMT", "inhibits", "nuclear", "translocation", "of", "both", "HIV-1", "transactivator", "(", "TAT", ")", "and", "the", "cellular", "transcriptional", "nuclear", "factor-KB", "(", "NF-kappa", "B", ")", ",", "resulting", "in", "the", "suppression", "of", "HIV-1", "replication", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 10, 10, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "To", "determine", "the", "mechanism", "of", "action", "of", "Ro", "09-2210", ",", "we", "set", "up", "a", "transient", "expression", "system", "in", "Jurkat", "T", "cells", "using", "a", "variety", "of", "reporter", "gene", "constructs", "and", "showed", "effective", "inhibition", "of", "phorbol", "ester/ionomycin-induced", "NF-AT", "activation", "and", "anti-CD3", "induced", "NF-AT", "with", "IC50", "=", "7.7", "and", "10", "nM", ",", "respectively", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "mechanism", "is", "suggested", "whereby", "expression", "of", "c-jun", "and", "junB", ",", "in", "the", "absence", "of", "members", "of", "the", "fos", "family", ",", "can", "prevent", "inappropriate", "activation", "of", "T", "cells", "caused", "by", "ligation", "of", "CD28", "in", "the", "absence", "of", "a", "specific", "antigenic", "stimulus", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Dominant", "cytotoxic", "T", "lymphocyte", "response", "to", "the", "immediate-early", "trans-activator", "protein", ",", "BZLF1", ",", "in", "persistent", "type", "A", "or", "B", "Epstein-Barr", "virus", "infection", "." ]

[ 0, 7, 8, 8, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "It", "now", "remains", "to", "be", "investigated", "which", "parameters", "determine", "the", "repertoire", "of", "the", "memory", "response", "and", "possibly", "restrict", "its", "diversity", "after", "subsequent", "antigenic", "challenges", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Immortalization", "of", "CD4", "(", "+", ")", "and", "CD8", "(", "+", ")", "T", "lymphocytes", "by", "human", "T-cell", "leukemia", "virus", "type", "1", "Tax", "mutants", "expressed", "in", "a", "functional", "molecular", "clone", "." ]

[ 0, 0, 7, 8, 8, 8, 8, 8, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 5, 6, 6, 0 ]

[ "All", "three", "stimuli", "induced", "IL-10", "production", "in", "PBMC", ",", "although", "over", "10-fold", "less", "IL-10", "was", "released", "in", "response", "to", "C.", "neoformans", "compared", "with", "LPS", "and", "C.", "albicans", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 7, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "LMP-1", ",", "an", "Epstein-Barr", "virus", "membrane", "protein", "expressed", "during", "latent", "infection", ",", "has", "oncogenic", "properties", ",", "as", "judged", "from", "its", "ability", "to", "transform", "B", "lymphocytes", "and", "rodent", "fibroblasts", "." ]

[ 9, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 8, 0 ]

[ "Tax1", ",", "a", "potent", "activator", "of", "human", "T-cell", "lymphotropic", "virus", "type", "1", "(", "HTLV-1", ")", "transcription", ",", "has", "been", "shown", "to", "modulate", "expression", "of", "many", "cellular", "genes", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "ETS", "transcription", "factors", "regulate", "an", "enhancer", "activity", "in", "the", "third", "intron", "of", "TNF-alpha", "." ]

[ 9, 10, 10, 0, 0, 0, 0, 0, 0, 1, 2, 0, 9, 0 ]

[ "A", "series", "of", "uninfected", "parental", "HL-60", "subclones", "all", "reduced", "TR75", "surface", "expression", "in", "response", "to", "TNF-alpha", "treatment", "." ]

[ 0, 0, 0, 5, 6, 6, 6, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "However", ",", "an", "excess", "of", "rapamycin", "is", "needed", "to", "revert", "FK506-mediated", "inhibition", "of", "IL-2", "production", ",", "apoptosis", ",", "and", "transcriptional", "activation", "of", "NF-AT", ",", "a", "T-cell-specific", "transcription", "factor", "necessary", "for", "IL-2", "gene", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 1, 2, 0, 0 ]

[ "The", "lytic", "cycle", "of", "EBV", "infection", "was", "induced", "by", "transfection", "of", "the", "cells", "with", "the", "BRLF1/BZLF1", "coding", "region", "of", "the", "P3HR-1", "defective", "genome", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0 ]

[ "Anti-", "CD28", "MoAb", "costimulation", "increased", "NF", "kappa", "B", "levels", "in", "neonates", ",", "albeit", "to", "levels", "lower", "than", "that", "of", "adults", "." ]

[ 0, 9, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "investigated", "the", "involvement", "of", "signal", "transducers", "and", "activators", "of", "transcription", "(", "STAT", ")", "factors", "in", "this", "phenomenon", "and", "reported", "the", "specific", ",", "time-dependent", ",", "activation", "of", "STAT1", "protein", "starting", "at", "day", "0/1", "of", "cultivation", "and", "maximally", "expressed", "at", "day", "5", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Regions", "of", "low", "potential", "in", "a", "68.5-kb", "genomic", "segment", "containing", "the", "FOSB", "gene", "suggest", "that", "the", "potential", "may", "help", "locate", "genes", "in", "uncharted", "DNA", "sequences", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]

[ "The", "induction", "of", "these", "genes", "is", "associated", "with", "interleukin-2", "(", "IL-2", ")", "-induced", "T-cell", "proliferation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0 ]

[ "CD36", "is", "a", "cell", "surface", "glycoprotein", "composed", "of", "a", "single", "polypeptide", "chain", ",", "which", "interacts", "with", "thrombospondin", ",", "collagens", "type", "I", "and", "IV", ",", "oxidized", "low", "density", "lipoprotein", ",", "fatty", "acids", ",", "anionic", "phospholipids", ",", "and", "erythrocytes", "parasitized", "with", "Plasmodium", "falciparum", "." ]

[ 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]

[ "Thus", ",", "these", "experiments", "demonstrate", "that", "EBNA2", "interacts", "with", "an", "EBNA2", "responsive", "cis-element", "of", "the", "TP1", "promoter" ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2 ]

[ "The", "data", "presented", "strongly", "support", "a", "role", "for", "this", "transcription", "factor", "in", "B-cell", "differentiation", "and", "perhaps", "in", "B-cell", "transformation", "in", "some", "neoplasias", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Activation", "of", "THP-1", "cells", "with", "gamma-interferon", "(", "gamma-IFN", ")", "enhances", "1", ",", "25", "(", "OH", ")", "2D3", "synthesis", "30-fold", ",", "blocks", "1", ",", "25-", "(", "OH", ")", "2D3", "suppression", "of", "its", "synthesis", ",", "and", "reduces", "by", "42.2", "%", "1", ",", "25-", "(", "OH", ")", "2D3", "induction", "of", "its", "degradation", "." ]

[ 0, 0, 5, 6, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "regulated", "interaction", "may", "be", "important", "for", "the", "coordination", "of", "lineage-specific", "effector", "functions", "such", "as", "lymphokine", "production", "with", "cell", "cycle", "progression", "in", "activated", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "Thus", ",", "coupling", "of", "TCR-regulated", "PTKs", "to", "downstream", "signaling", "pathways", "requires", "SLP-76", "." ]

[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 0 ]

[ "In", "fact", ",", "transgenic", "bone", "marrow", "cells", "cocultured", "with", "a", "bone", "marrow-derived", "stromal", "cell", "line", "revealed", "an", "altered", "B-cell", "maturation", "pattern", "." ]

[ 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 7, 0, 0, 0 ]

[ "Stimulation", "of", "B", "and", "T", "cells", "activates", "expression", "of", "transcription", "and", "differentiation", "factors", "." ]

[ 0, 0, 7, 8, 8, 8, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "The", "higher", "affinity", "sites", "bind", "CVZ", "with", "20-", "to", "50-fold", "greater", "affinity", ",", "consistent", "with", "CVZ", "'s", "enhanced", "biological", "effects", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "conclude", "that", "the", "human", "c-fes", "gene", "contains", "a", "strong", "myeloid-cell-specific", "promoter", "that", "is", "regulated", "by", "Sp1", ",", "PU.1", ",", "and", "a", "novel", "transcription", "factor", "." ]

[ 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 9, 10, 0 ]

[ "To", "evaluate", "this", "possibility", ",", "we", "examined", "in", "vitro", "the", "effects", "of", "two", "types", "of", "antioxidant", "molecules", "in", "terms", "of", "inhibition", "of", "HIV", "replication", "in", "monocytes", ",", "one", "of", "the", "main", "reservoirs", "of", "HIV", ",", "and", "also", "in", "terms", "of", "modulation", "of", "the", "immune", "competence", "as", "measured", "by", "PBMC", "proliferation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]

[ "These", "effects", "of", "aldosterone", "were", "blocked", "by", "the", "aldosterone", "antagonist", "canrenone", "(", "140", "nmol/l", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "An", "additional", "distinguishing", "characteristic", "of", "HTLV-I", "infection", "is", "the", "profound", "state", "of", "viral", "latency", "that", "is", "present", "in", "circulating", "primary", "leukemic", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]

[ "CD40", "expression", "was", "confirmed", "in", "7", "human", "MM", "cell", "lines", "established", "from", "immunogenic", "primary", "tumors", "or", "metastases", ",", "whereas", "11", "cell", "lines", "established", "from", "advanced", "stages", "were", "CD40", "negative", "." ]

[ 9, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "Leukotriene", "B4", "(", "LTB4", ")", "is", "a", "notable", "participant", "in", "inflammation", "and", "chemotaxis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "situ", "hybridization", "showed", "that", "apart", "from", "lymphocytes", ",", "thyroid", "cells", "themselves", "were", "the", "source", "of", "MHC", "II", "transcripts", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 8, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "The", "IL-3", ",", "IL-5", "and", "GM-CSF", "receptors", "share", "a", "common", "signal", "transducer", "that", "possesses", "no", "intrinsic", "kinase", "domain", "." ]

[ 0, 9, 0, 9, 0, 9, 10, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 10, 0 ]

[ "These", "data", "provide", "the", "first", "demonstration", "in", "vivo", "that", "activation", "of", "a", "protein", "phosphatase", "can", "inactivate", "I", "kappa", "B", ",", "and", "suggest", "one", "possible", "explanation", "for", "mechanism-based", "toxicities", "associated", "with", "FK-506", "and", "CsA", "by", "demonstrating", "that", "these", "drugs", "can", "inhibit", "the", "calcineurin", "-dependent", "activation", "of", "a", "virtually", "ubiquitous", "transcription", "factor", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "However", ",", "the", "real", "effect", "of", "hormones", "involved", "in", "ovulation", "is", "expressed", "by", "biological", "modifications", "on", "target", "tissues", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "These", "results", "suggest", "a", "microenvironment-directed", ",", "two-step", "model", "for", "GATA-1", "expression", "in", "differentiating", "hematopoietic", "progenitors", "that", "involves", "(", "i", ")", "cycle-dependent", "initiation", "and", "(", "ii", ")", "lineage-dependent", "maintenance", "or", "suppression", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "vitro", "studies", "demonstrated", "that", "whereas", "the", "binding", "affinity", "of", "NF-kappa", "B", "to", "the", "VCAM-NF-kappa", "B", "oligomer", "peaked", "at", "a", "GSH-to-oxidized", "glutathione", "(", "GSSG", ")", "ratio", "of", "approximately", "200", "and", "decreased", "at", "higher", "ratios", ",", "the", "binding", "to", "the", "E-selectin-NF-kappa", "B", "oligomer", "appeared", "relatively", "unaffected", "even", "at", "ratios", ">", "400", ",", "i.e.", ",", "those", "achieved", "in", "EC", "treated", "with", "40", "mM", "NAC", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0 ]

[ "Moreover", ",", "the", "mechanism", "of", "action", "of", "BHRF1", "resembled", "that", "of", "Bcl-2", "and", "Bcl-xL", "as", "it", "inhibited", "TNF-", "and", "anti-Fas-induced", "activation", "of", "two", "enzymes", "participating", "in", "the", "apoptosis", "pathway", ",", "cytosolic", "phospholipase", "A2", "and", "caspase-3/CPP32", ",", "but", "did", "not", "interfere", "with", "the", "activation", "of", "NF-kappaB-like", "transcription", "factors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "Functional", "interaction", "between", "the", "two", "zinc", "finger", "domains", "of", "the", "v-erb", "A", "oncoprotein", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 0 ]

[ "Towards", "a", "molecular", "understanding", "of", "T-cell", "differentiation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Interleukin-6", "(", "IL-6", ")", "plays", "a", "central", "role", "in", "numerous", "inflammatory", "and", "immune", "processes", "." ]

[ 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "and", "others", "have", "shown", "that", "EBV", "can", "also", "infect", "a", "subset", "of", "thymocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]

[ "Our", "data", "indicate", "an", "important", "role", "for", "NF-AT", "in", "the", "faithful", "expression", "of", "high", "affinity", "IL-2", "receptors", "and", "a", "close", "link", "between", "the", "TCR", "-mediated", "induction", "of", "IL-2", "and", "IL-2", "receptor", "alpha", "chain", "promoters", ",", "both", "of", "which", "are", "regulated", "by", "NF-AT", "factors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "We", "found", "that", "they", "reduced", "the", "initial", "interleukin-1beta", "mRNA", "transcription", "rate", "through", "prevention", "of", "degradation", "of", "inhibitor-kappaB", "alpha", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "VDR", "is", "functionally", "active", "in", "ATRA-treated", "Kasumi-1", "cells", "because", "it", "efficiently", "heterodimerizes", "with", "retinoid", "X", "receptor", ",", "binds", "to", "a", "DR3-type", "vitamin", "D-responsive", "element", ",", "and", "activates", "the", "transcription", "of", "a", "vitamin", "D-responsive", "element-regulated", "reporter", "gene", "." ]

[ 9, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0 ]

[ "Induction", "of", "Jurkat", "leukemic", "T", "cells", "with", "phorbol", "12-myristate", "13-acetate", "and", "ionomycin", "did", "not", "affect", "the", "level", "of", "FKBP", "mRNA", "." ]

[ 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0 ]

[ "A", "nondegradable", "mutant", "of", "I", "kappa", "B", "blocked", "both", "FasL", "expression", "and", "apoptosis", "induced", "by", "DNA", "damage", "but", "not", "Fas", "ligation", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "Encephalomyocarditis", "virus", "internal", "ribosomal", "entry", "site", "RNA-protein", "interactions", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "NAC", "inhibited", "interleukin-1", "(", "IL-1", "beta", ")", "-induced", ",", "but", "not", "basal", ",", "adhesion", "with", "50", "%", "inhibition", "at", "approximately", "20", "mM", "." ]

[ 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Fourteen", "percent", "of", "isolated", "fragments", "belong", "to", "already", "known", "genes", "that", "certainly", "are", "cytokines", "and", "transduction/transcription", "factors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0 ]

[ "Acquisition", "of", "HSF3", "DNA-binding", "activity", "in", "HD6", "cells", "is", "accompanied", "by", "oligomerization", "from", "a", "non-DNA-binding", "dimer", "to", "a", "DNA-binding", "trimer", ",", "whereas", "the", "effect", "of", "heat", "shock", "on", "HSF1", "is", "oligomerization", "of", "an", "inert", "monomer", "to", "a", "DNA-binding", "trimer", "." ]

[ 0, 0, 9, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 0 ]

[ "We", "report", "the", "identification", "and", "characterization", "of", "simple", "tandem", "repeat", "DNA", "polymorphisms", "in", "the", "genes", "encoding", "HNF-3alpha", ",", "-3beta", ",", "-3gamma", ",", "-4gamma", ",", "and", "-6", "and", "the", "mapping", "of", "HNF-6", "to", "chromosome", "bands", "15q21.1-21.2", "by", "fluorescence", "in", "situ", "hybridization", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 9, 0, 1, 2, 1, 0, 0, 0, 0, 0, 0 ]

[ "We", "have", "found", "that", ",", "in", "the", "human", "pro-monocytic", "cell", "line", ",", "THP-1", ",", "the", "lipopolysaccharide-induced", "expression", "of", "interleukin", "1beta", "is", "dependent", "on", "tyrosine", "kinase", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 5, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 0, 0 ]

[ "More", "extensive", "deletion", "of", "sequences", "upstream", "of", "Cp", ",", "including", "the", "EBNA2-dependent", "enhancer", ",", "resulted", "in", "nearly", "complete", "loss", "of", "Cp", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0 ]

[ "We", "have", "also", "examined", "how", "one", "5'HS", "affects", "the", "recruitment", "of", "EKLF", "to", "another", "5'HS", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 9, 0, 0, 1, 0 ]

[ "However", ",", "in", "3", "postmenopausal", "patients", "a", "short", "course", "of", "estrogen", "or", "tamoxifen", "resulted", "in", "a", "marked", "increase", "of", "type", "II", "EBS", "levels", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0 ]

[ "In", "addition", ",", "in", "vitro", "differentiation", "of", "monocytes", "to", "a", "macrophage-like", "cell", "resulted", "in", "decreased", "amounts", "of", "REF-1", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 7, 8, 0, 0, 0, 0, 0, 9, 0 ]

[ "Sodium", "salicylate", "and", "aspirin", "also", "inhibited", "NF-kappa", "B", "-dependent", "transcription", "from", "the", "Ig", "kappa", "enhancer", "and", "the", "human", "immunodeficiency", "virus", "(", "HIV", ")", "long", "terminal", "repeat", "(", "LTR", ")", "in", "transfected", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 0, 1, 0, 0, 5, 6, 6, 0 ]

[ "Furthermore", ",", "ethanol", ",", "an", "inhibitor", "of", "the", "PLD", "pathway", ",", "blocked", "the", "anti-CD3-stimulated", "AP-1", "enhancer", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]

[ "No", "NF-IL-6", "binding", "activity", "was", "detected", "in", "the", "same", "nuclear", "extracts", "." ]

[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Cell", "type", "specificity", "and", "activation", "requirements", "for", "NFAT-1", "(", "nuclear", "factor", "of", "activated", "T-cells", ")", "transcriptional", "activity", "determined", "by", "a", "new", "method", "using", "transgenic", "mice", "to", "assay", "transcriptional", "activity", "of", "an", "individual", "nuclear", "factor", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "They", "fail", "to", "induce", "mRNA", "of", "TNF-alpha", "after", "3", "h", "of", "culture", "." ]

[ 0, 0, 0, 0, 3, 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "the", "intensity", "of", "p65", "labeling", "was", "much", "higher", "in", "several", "thymocytes", "from", "the", "medulla", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0 ]

[ "Interaction", "of", "transcription", "factors", "RFX1", "and", "MIBP1", "with", "the", "gamma", "motif", "of", "the", "negative", "regulatory", "element", "of", "the", "hepatitis", "B", "virus", "core", "promoter", "." ]

[ 0, 0, 9, 10, 9, 0, 9, 0, 0, 1, 2, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 2, 2, 0 ]

[ "Interferon-alpha", "and", "-beta", "promote", "the", "reversion", "of", "blast", "Tcells", "to", "a", "resting", "G0/G1", "configuration", "with", "all", "the", "characteristic", "features", "of", "stromal", "cell", "rescue", ";", "such", "as", "high", "Bcl-XL", "expression", "and", "low", "Bcl-2", "." ]

[ 9, 10, 10, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0 ]

[ "TNF", "-mediated", "activation", "of", "NF-kappa", "B", "and", "cytotoxicity", "involves", "the", "intracellular", "formation", "of", "reactive", "oxygen", "intermediates", "." ]

[ 9, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "show", "that", "transcription", "of", "the", "BLR2", "gene", "could", "be", "specifically", "induced", "in", "Epstein-Barr", "virus", "negative", "BL", "41", "cells", "via", "estrogen-mediated", "activation", "of", "Epstein-Barr", "virus", "nuclear", "antigen", "2", ",", "a", "key", "regulator", "of", "viral", "and", "cellular", "genes", "in", "immortalized", "B", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 5, 6, 6, 0 ]

[ "The", "activation", "of", "NF-kappa", "B", "initiates", "both", "extracellular", "and", "intracellular", "regulatory", "events", "that", "result", "in", "autoregulation", "of", "the", "inflammatory", "cascade", "through", "modulation", "of", "NF-kappa", "B", "activation", "." ]

[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]

[ "NF-kappaB", "binding", "activity", "correlated", "with", "the", "degree", "of", "albuminuria", "(", "r", "=", "0.316", ")", "and", "with", "thrombomodulin", "plasma", "concentrations", "(", "r", "=", "0.33", ")", ",", "indicative", "for", "albuminuria", "associated", "endothelial", "dysfunction", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Activation", "of", "the", "granulocyte-macrophage", "colony-stimulating", "factor", "promoter", "in", "T", "cells", "requires", "cooperative", "binding", "of", "Elf-1", "and", "AP-1", "transcription", "factors", "." ]

[ 0, 0, 0, 1, 2, 2, 2, 0, 7, 8, 0, 0, 0, 0, 9, 0, 9, 9, 10, 0 ]

[ "Recent", "studies", "indicate", "that", "mutations", "in", "the", "androgen", "receptor", "gene", "are", "associated", "with", "androgen", "insensitivity", "syndromes", ",", "a", "heterogeneous", "group", "of", "related", "disorders", "involving", "defective", "sexual", "differentiation", "in", "karyotypic", "males", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Mitogen", "activation", "of", "human", "peripheral", "T", "lymphocytes", "induces", "the", "formation", "of", "new", "cyclic", "AMP", "response", "element-binding", "protein", "nuclear", "complexes", "." ]

[ 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0 ]

[ "However", ",", "blockade", "of", "the", "Ca", "(", "2+", ")", "-activated", "K+", "channel", "is", "not", "associated", "with", "changes", "in", "cell-cycle", "gene", "activation", ",", "IL-2", "production", ",", "IL-2R", "expression", "or", "B", "and", "T", "cell", "mitogenesis", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "mechanism", "(", "s", ")", "responsible", "for", "the", "cell", "type-specific", "regulation", "of", "TNF", "alpha", "is", "not", "known", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]

[ "These", "findings", "indicated", "that", "the", "expression", "of", "E2A-HLF", "induced", "T-cell", "apoptosis", "and", "B-cell", "maturation", "arrest", "in", "vivo", "and", "that", "the", "susceptibility", "of", "the", "transgenic", "mice", "to", "infection", "was", "due", "to", "immunodeficiency", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "It", "is", "known", "that", "the", "expression", "levels", "of", "intercellular", "adhesion", "molecule-1", "(", "ICAM-1", ")", "in", "adult", "T", "cell", "leukemia", "(", "ATL", ")", "cells", "are", "high", ",", "whereas", "those", "in", "T-lymphoid", "cells", "are", "not", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 7, 8, 8, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0 ]

[ "These", "studies", "strongly", "suggest", "that", "the", "process", "of", "differentiation", "of", "monocytes", "into", "alveolar", "macrophages", "is", "associated", "with", "a", "loss", "of", "REF-1", "and", "AP-1", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 8, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0 ]

[ "We", "show", "here", "that", "helenalin", ",", "and", ",", "to", "a", "much", "lesser", "degree", ",", "11alpha", ",", "13-dihydrohelenalin", "and", "chamissonolid", ",", "inhibit", "activation", "of", "transcription", "factor", "NF-kappaB", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0 ]

[ "They", "act", "at", "a", "point", "in", "activation", "that", "lies", "between", "receptor", "ligation", "and", "the", "transcription", "of", "early", "genes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "We", "determined", "the", "mechanism", "of", "NF-kappaB", "suppression", "in", "T", "cells", "of", "RCC", "patient", "and", "determined", "whether", "supernatant", "fluid", "from", "RCC", "explants", "(", "RCC-S", ")", "induced", "the", "same", "phenotype", "of", "NF-kappaB", "suppression", "in", "normal", "T", "cells", "that", "is", "observed", "in", "patient", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "Alternative", "splicing", "of", "exon", "10", "of", "the", "TSC2", "gene", "may", "be", "a", "normal", "variant", "." ]

[ 0, 0, 0, 3, 4, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0 ]

[ "Engagement", "of", "any", "of", "these", "receptors", "induces", "the", "rapid", "tyrosine", "phosphorylation", "of", "a", "shared", "group", "of", "intracellular", "signaling", "proteins", ",", "including", "Vav", ",", "Cbl", ",", "p85", "phosphoinositide", "3-kinase", ",", "and", "the", "Src", "family", "kinases", "Lck", "and", "Fyn", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 0, 9, 0, 9, 10, 10, 0, 0, 0, 9, 10, 10, 9, 0, 9, 0 ]

[ "NF", "kappa", "B", "is", "a", "potent", "mediator", "of", "specific", "gene", "expression", "in", "human", "monocytes", "and", "has", "been", "shown", "to", "play", "a", "role", "in", "transcription", "of", "the", "HIV-1", "genome", "in", "promonocytic", "leukemias", "." ]

[ 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "It", "may", "be", "possible", "to", "produce", "such", "cells", "by", "first", "expressing", "the", "Epo", "receptor", "under", "the", "influence", "of", "a", "constitutive", "promoter", "and", "then", "targeting", "the", "GATA-1", "gene", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "In", "this", "study", ",", "we", "have", "identified", "a", "kinase", "in", "cell", "extracts", "from", "the", "LPS-stimulated", "human", "monocytic", "cell", "line", ",", "THP-1", ",", "that", "specifically", "binds", "and", "phosphorylates", "I", "kappa", "B", "alpha", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 5, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "The", "exact", "role", "of", "these", "different", "proteins", "in", "directing", "the", "tissue-specific", "expression", "of", "immunoglobulin", "genes", "is", "unclear", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0 ]

[ "In", "both", "cell", "types", "the", "cellular", "levels", "of", "IkappaBalpha", "mRNA", "and", "protein", "were", "evaluated", "by", "DEX", "treatment", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Taken", "together", ",", "these", "results", "demonstrate", "that", "MyD88", "is", "a", "critical", "component", "in", "the", "signaling", "cascade", "that", "is", "mediated", "by", "IL-1", "receptor", "as", "well", "as", "IL-18", "receptor", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 0 ]

[ "Stimulation", "of", "mature", "peripheral", "T", "cells", "by", "TCR", "engagement", "results", "in", "activation", "of", "signals", "that", "drive", "induction", "of", "cytokine", "gene", "expression", "and", "clonal", "expansion", "." ]

[ 0, 0, 7, 8, 8, 8, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]