id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
16125
[ "Glucocorticoid", "receptors", "(", "GcR", ")", "were", "determined", "by", "a", "whole", "cell", "assay", "in", "human", "mononulear", "leukocytes", "(", "hMNL", ")", "from", "control", "subjects", ",", "patients", "receiving", "glucocorticoid", "therapy", "for", "systemic", "diseases", "and", "Cushing", "'s", "disease", "patients", "with", "or", "without", "ketoconazole", "therapy", "." ]
[ 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15165
[ "The", "GR", "in", "peripheral", "blood", "leukocytes", "in", "aged", "runner", "was", "65", "%", "of", "the", "control", "." ]
[ 0, 9, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10445
[ "Cytomegalovirus", "(", "CMV", ")", "infection", "induced", "interleukin-8", "(", "IL-8", ")", "gene", "transcription", "in", "a", "human", "monocytic", "cell", "line", ",", "THP-1", "cells", ",", "leading", "to", "IL-8", "secretion", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 5, 6, 0, 0, 0, 9, 0, 0 ]
10600
[ "By", "electrophoretic", "mobility", "shift", "assays", ",", "this", "increase", "in", "mRNA", "was", "associated", "with", "a", "5-", "to", "10-fold", "increase", "in", "the", "STAT1-containing", "DNA-binding", "complex", "that", "binds", "to", "Fc", "gammaRI", "promoter", "elements", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 1, 2, 2, 2, 0 ]
9866
[ "A", "human", "IL-5", "promoter/enhancer", "luciferase", "gene", "construct", "transfected", "into", "IL-5-producing", "T", "cell", "clones", "was", "clearly", "transcribed", "after", "stimulation", ",", "indicating", "that", "the", "515", "base", "pair", "IL-5", "gene", "segment", "upstream", "of", "the", "coding", "region", "was", "sufficient", "to", "respond", "to", "activating", "signals", "in", "human", "helper", "T", "cells", "." ]
[ 0, 0, 1, 2, 2, 2, 2, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
1808
[ "These", "results", "suggest", "that", "cooperation", "among", "NF-kappa", "B-", ",", "AP-1-", "and", "NF-AT-binding", "sequences", "is", "required", "for", "induction", "of", "the", "GM-CSF", "gene", "through", "PKC-", "and", "Ca2+-", "signaling", "pathways", "downstream", "of", "T", "cell", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9150
[ "By", "using", "PD-98059", "and", "SB203580", ",", "two", "potent", "and", "selective", "inhibitors", "of", "MEK1", "(", "a", "kinase", "upstream", "of", "ERK1/2", ")", "and", "p38", ",", "respectively", ",", "we", "have", "demonstrated", "that", "both", "ERK1/2", "and", "p38", "cascades", "play", "a", "key", "role", "in", "the", "production", "of", "IL-8", "by", "monocytes", "and", "PMN", "stimulated", "with", "bacterial", "fractions", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 0, 7, 0, 0, 0, 0, 0 ]
65
[ "This", "is", "in", "contrast", "to", "the", "infection", "in", "B", "cells", "where", "the", "genome", "can", "circularize", "within", "24", "hr", "of", "infection", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17363
[ "Complementary", "DNA", "(", "cDNA", ")", "encoding", "a", "human", "TFIID", "protein", "has", "been", "cloned", "." ]
[ 1, 2, 0, 1, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0 ]
14424
[ "NF-kappa", "B", "controls", "expression", "of", "inhibitor", "I", "kappa", "B", "alpha", ":", "evidence", "for", "an", "inducible", "autoregulatory", "pathway", "." ]
[ 9, 10, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
5372
[ "Large", "amounts", "of", "AP-1", "and", "NF-kappa", "B", "and", "significant", "quantities", "of", "NF-AT", "were", "induced", "in", "SEA-activated", "CD4+", "spleen", "T", "cells", ",", "whereas", "Oct-1", "and", "Oct-2", "DNA", "binding", "activity", "was", "similar", "in", "both", "resting", "and", "activated", "T", "cells", "." ]
[ 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 9, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
8568
[ "We", "demonstrate", "the", "utility", "of", "using", "primary", "lymphocyte", "models", "to", "study", "HTLV-I", "transcription", "in", "the", "context", "of", "cell", "signaling", "and", "suggest", "that", "activated", "PBMC", "maintain", "elevated", "levels", "of", "P-CREB", ",", "which", "promote", "basal", "HTLV-I", "transcription", "and", "enhance", "viral", "persistence", "in", "vivo", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3982
[ "In", "preliminary", "studies", ",", "we", "have", "analyzed", "the", "hematopoietic", "growth", "factor", "(", "HGF", ")", "requirement", "of", "hematopoietic", "progenitor", "cells", "(", "HPCs", ")", "purified", "from", "embryonic-fetal", "liver", "(", "FL", ")", "and", "grown", "in", "fetal", "calf", "serum-supplemented", "(", "FCS+", ")", "clonogenic", "culture", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 7, 8, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14192
[ "Down", "syndrome", "(", "DS", ")", "and", "neuronal", "ceroid-lypofuscinosis", "(", "NCL", ")", "are", "clinically", "characterized", "by", "the", "premature", "onset", "of", "numerous", "features", "normally", "associated", "with", "human", "aging", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11868
[ "Therefore", ",", "inactivation", "of", "the", "IgH", "3", "'", "enhancer", "is", "a", "multifactorial", "process", "affecting", "several", "transcription", "factors", "that", "control", "the", "cell-specific", "and", "developmental", "activity", "of", "the", "enhancer", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0 ]
1345
[ "Mutations", "of", "the", "genuine", "octamer-binding", "site", "abrogate", "both", "the", "binding", "of", "Oct-1", "and", "Oct-2", "and", "the", "TPA/Ca", "(", "2+", ")", "-induced", "transactivation", "of", "the", "OAP/octamer", "motif", "." ]
[ 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
2574
[ "An", "HHV-6", "(", "GS", ")", "cDNA", "clone", ",", "pCD41", ",", "encoding", "for", "a", "41-kDa", "nuclear", "protein", "was", "identified", "and", "characterized", "previously", "(", "Chang", "and", "Balachandran", ",", "J.", "Virol.", "65", ",", "2884-2894", "and", "7085", ",", "1991", ")", "." ]
[ 0, 1, 2, 2, 2, 2, 2, 0, 1, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17534
[ "Such", "tests", "may", "become", "useful", "diagnostic", "tools", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0 ]
6450
[ "Similar", "inhibitory", "effects", "were", "observed", "with", "other", "cytokines", "that", "use", "gamma", "(", "c", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 10, 0 ]
15095
[ "These", "results", "can", "not", "be", "explained", "by", "receptor", "down-regulation", "due", "to", "higher", "levels", "of", "mineralocorticoids", "in", "PIH", ";", "a", "hitherto", "unknown", "mineralocorticoid", "may", ",", "thus", ",", "be", "responsible", "for", "the", "hypertension", "and", "altered", "MR", "status", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
2762
[ "When", "responses", "to", "G", "(", "Anh", ")", "MTetra", "were", "compared", "with", "those", "to", "LPS", "and", "muramyldipeptide", "(", "MDP", ")", ",", "it", "was", "found", "that", "the", "optimal", "response", "to", "G", "(", "Anh", ")", "MTetra", "induction", "was", "similar", "to", "that", "of", "LPS", "but", "significantly", "higher", "than", "the", "response", "to", "MDP", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3519
[ "We", "show", "that", "the", "constitutive", "nuclear", "translocation", "of", "NF-ATp", ",", "a", "member", "of", "the", "growing", "family", "of", "NF-AT", "factors", ",", "is", "a", "hallmark", "of", "nonstimulated", "B", "cells", "from", "CLL", "patients", "that", "distinguishes", "B-CLL", "cells", "from", "'normal", "'", "B", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 7, 8, 0, 7, 8, 8, 8, 0 ]
12262
[ "T", "cell", "receptor", "(", "TCR", ")", "stimulation", "induces", "rapid", "tyrosine", "phosphorylation", "of", "cellular", "proteins", ",", "including", "Cbl", ",", "a", "protooncogene", "product", "whose", "function", "remains", "unclear", "." ]
[ 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
18538
[ "HIV-1", "envelope", "glycoproteins", "induce", "activation", "of", "activated", "protein-1", "in", "CD4+", "T", "cells", "[", "published", "erratum", "appears", "in", "J", "Biol", "Chem", "1995", "Dec", "1", ";", "270", "(", "48", ")", ":", "29038", "]" ]
[ 9, 10, 10, 0, 0, 0, 0, 9, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11622
[ "This", "degree", "of", "cell", "damage", "was", "not", "observed", "in", "Ad5wt", "or", "H5sub304", "infection", "of", "CREF", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
11583
[ "Ascorbate", "and", "AZT", "also", "had", "no", "effect", "on", "NF-kappa", "B", "activation", "following", "TNF-alpha-", "or", "PMA-induced", "stimulation", "of", "U1", "promonocytic", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12325
[ "Association", "of", "JAK1", "and", "STAT5", "was", "found", "to", "occur", "exclusively", "between", "unphosphorylated", "proteins", "." ]
[ 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
929
[ "Maximal", "induction", "of", "TNF", "alpha", "mRNA", "can", "be", "induced", "by", "treatment", "of", "T", "cells", "with", "calcium", "ionophores", "alone", ",", "via", "a", "calcineurin", "-dependent", "process", "that", "is", "blocked", "by", "cyclosporin", "A", "." ]
[ 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5048
[ "To", "identify", "cellular", "proteins", "binding", "to", "TRE-1", "in", "a", "Tax", "-dependent", "manner", ",", "this", "strain", "was", "also", "used", "to", "screen", "a", "library", "of", "human", "cDNAs", "fused", "to", "GAD", "." ]
[ 0, 0, 9, 10, 0, 0, 1, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 9, 0 ]
7069
[ "In", "addition", ",", "sodium", "salicylate", "and", "additional", "NSAIDs", "used", "at", "concentrations", "that", "activate", "HSF1", "also", "inhibited", "the", "expression", "of", "other", "monocytic", "genes", "(", "TNF-alpha", ",", "IL-1beta", ",", "IL-6", ",", "IL-8", ",", "IL-10", ",", "ICAM-1", ")", "activated", "by", "exposure", "to", "a", "pro-inflammatory", "stimulus", "(", "lipopolysaccharide", ",", "LPS", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 0, 1, 0, 1, 0, 1, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6066
[ "IL-10", "is", "a", "potent", "mediator", "of", "human", "B", "cell", "growth", "and", "plasma", "cell", "formation", "." ]
[ 9, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0 ]
10884
[ "Screening", "of", "a", "library", "of", "compounds", "using", "transactivation", "and", "AP-1", "transrepression", "models", "in", "transiently", "transfected", "cells", "identified", "dissociated", "glucocorticoids", ",", "which", "exert", "strong", "AP-1", "inhibition", "but", "little", "or", "no", "transactivation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
16728
[ "These", "results", "imply", "that", "membrane", "potential", "changes", "secondary", "to", "the", "ligand-dependent", "opening", "of", "Ca", "(", "2+", ")", "-activated", "K+", "channels", "are", "not", "involved", "in", "B", "and", "T", "lymphocyte", "activation", "and", "mitogenesis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0 ]
2281
[ "An", "interleukin-4-induced", "transcription", "factor", ":", "IL-4", "Stat", "." ]
[ 0, 9, 10, 10, 0, 9, 10, 0 ]
1669
[ "We", "had", "previously", "found", "that", "aspirin-like", "drugs", "(", "ALD", ")", "induce", "AP-1", "in", "human", "T", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 8, 0 ]
15410
[ "This", "induction", "of", "monocytic", "differentiation", "was", "associated", "with", "transient", "increases", "in", "c-jun", "mRNA", "levels", ",", "which", "were", "maximal", "at", "6", "h", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
13146
[ "Increased", "IL-6", "protein", "expression", "was", "localized", "to", "bronchial", "and", "alveolar", "cells", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]
14845
[ "Basing", "on", "these", "experiments", ",", "trans-cellular", "activation", "of", "EBV", "was", "tested", "by", "cocultivation", "of", "BZLF", "1-expressing", "R59Z", "activator", "cells", "with", "the", "R7-57", "reporter", "line", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 5, 6, 6, 0 ]
15529
[ "Thus", "enabled", "to", "perform", "the", "test", "on", "multiple", "blood", "samples", "in", "parallel", ",", "we", "investigated", "cardiac", "infarction", "patients", "over", "a", "12-day", "period", "to", "test", "if", "glucocorticoid", "receptor", "binding", "is", "altered", "in", "this", "'stressful", "'", "disease", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3925
[ "Here", "we", "describe", "the", "isolation", "and", "expression", "of", "a", "cDNA", "encoding", "PTF", "beta", ",", "as", "well", "as", "functional", "studies", "using", "anti-PTF", "beta", "antibodies", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
12413
[ "Dexamethasone", ",", "a", "glucocorticoid", "that", "is", "widely", "used", "as", "an", "immunomodulatory", "and", "anti-inflammatory", "agent", ",", "inhibits", "granzyme", "B", "mRNA", "transcript", "in", "phytohemagglutinin-activated", "peripheral", "blood", "mononuclear", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 7, 8, 8, 8, 8, 0 ]
17462
[ "GCR", "on", "MNL", "and", "PML", "in", "6", "Yang", "deficient", "patients", "were", "3473", "+/-", "413", "and", "4433", "+/-", "651", "sites/cell", "respectively", ",", "statistically", "significant", "from", "the", "normal", "control", "group", "(", "4462", "+/-", "962", "and", "5622", "+/-", "782", "sites/cell", "respectively", ",", "P", "less", "than", "0.05", ")", "." ]
[ 9, 0, 7, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8543
[ "To", "investigate", "the", "events", "involved", "in", "activation-induced", "Fas", "upregulation", ",", "we", "have", "examined", "mRNA", "accumulation", ",", "fas", "promoter", "activity", ",", "and", "protein", "expression", "in", "the", "Jurkat", "T-cell", "line", "treated", "with", "phorbol", "myristate", "acetate", "and", "ionomycin", "(", "P/I", ")", ",", "pharmacological", "mimics", "of", "T-cell", "receptor", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]
15204
[ "A", "30-bp", "sequence", "in", "the", "BMRF1", "promoter", "which", "contains", "a", "Z", "binding", "site", "(", "a", "consensus", "AP-1", "site", ")", "is", "sufficient", "to", "transfer", "high-level", "lymphoid-specific", "responsiveness", "to", "the", "Z/c-myb", "combination", "to", "a", "heterologous", "promoter", "." ]
[ 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 1, 2, 0 ]
9838
[ "We", "found", "a", "constitutive", "degradation", "of", "I", "kappa", "B-alpha", ",", "the", "major", "cytoplasmic", "inhibitor", "of", "nuclear", "factor", "kappa", "B", "(", "NF-kappa", "B", ")", ",", "in", "freshly", "isolated", "PBMC", "and", "monocytes", "from", "patients", "with", "tuberculosis", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 0, 9, 10, 10, 10, 0, 9, 10, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 0, 0 ]
1462
[ "Two", "distinct", "signalling", "pathways", "are", "involved", "in", "the", "control", "of", "the", "biphasic", "junB", "transcription", "induced", "by", "interleukin-6", "in", "the", "B", "cell", "hybridoma", "7TD1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 9, 0, 0, 5, 6, 6, 6, 0 ]
2962
[ "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]
[ 0, 0, 0, 0, 0, 0, 0 ]
8771
[ "Functional", "analyses", "of", "DNA", "fragments", "containing", "the", "TATA", "element", "and", "the", "identification", "of", "a", "DNase", "I-hypersensitive", "chromatin", "site", "(", "HS", "1", ")", "in", "close", "proximity", "to", "the", "TATA", "box", "suggest", "that", "the", "identified", "TATA", "motif", "is", "important", "for", "elk-1", "transcription", "in", "vivo", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 0, 0, 0, 0 ]
17885
[ "The", "C-terminal", "domain", "of", "the", "precursor", "is", "rapidly", "degraded", ",", "forming", "the", "mature", "p50", "subunit", "consisted", "of", "the", "N-terminal", "region", "of", "the", "molecule", "." ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]
11502
[ "A", "protein", "of", "about", "150", "kD", "that", "bound", "to", "this", "negative", "regulatory", "sequence", "was", "identified", "by", "UV", "cross-linking", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0 ]
13885
[ "In", "this", "study", ",", "we", "examined", "the", "biologic", "mediators", "that", "may", "regulate", "the", "expression", "of", "TGF-alpha", "and", "-beta1", "by", "eosinophils", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 7, 0 ]
12568
[ "Few", ",", "if", "any", ",", "studies", "have", "been", "made", "on", "the", "impact", "of", "these", "compounds", "on", "the", "immune", "system", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17488
[ "The", "functions", "of", "these", "proteins", "can", "be", "antagonized", "by", "several", "methods", ",", "each", "with", "specific", "limitations", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
339
[ "A", "conserved", "motif", "in", "the", "promoters", "of", "several", "cytokines", "expressed", "by", "human", "Th2-type", "lymphocytes", "." ]
[ 0, 1, 2, 0, 0, 1, 0, 0, 9, 0, 0, 5, 6, 6, 0 ]
8635
[ "Two", "CAGGTG", "E-boxes", ",", "located", "at", "the", "5'-", "and", "3'-ends", "of", "the", "silencer", ",", "were", "necessary", "for", "this", "silencer", "activity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5123
[ "Similar", "downregulation", "of", "BCL-6", "mRNA", "was", "seen", "in", "human", "B", "cells", "stimulated", "with", "Staphylococcus", "aureus", "plus", "interleukin-2", "or", "anti-IgM", "antibodies", "and", "in", "human", "T", "lymphocytes", "stimulated", "with", "phytohemagglutinin", "." ]
[ 0, 0, 0, 3, 4, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 7, 8, 8, 0, 0, 9, 0 ]
12627
[ "Collectively", ",", "we", "have", "identified", "the", "RALDH2", "gene", "as", "a", "first", "example", "of", "direct", "transcriptional", "target", "genes", "regulated", "by", "TAL1", "and", "LMO", "in", "T-ALL", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 9, 0, 9, 0, 0, 0 ]
10457
[ "Therefore", ",", "we", "have", "constructed", "a", "single", "cDNA", "that", "encodes", "a", "single-chain", "protein", ",", "called", "Flexi-12", ",", "which", "retains", "all", "of", "the", "biological", "characteristics", "of", "recombinant", "IL-12", "(", "rIL-12", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0 ]
9502
[ "We", "report", "that", "both", "YY1", "and", "LSF", "participate", "in", "the", "formation", "of", "a", "complex", "that", "recognizes", "the", "initiation", "region", "of", "the", "HIV-1", "LTR", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
4837
[ "Resting", "T", "cells", "express", "very", "low", "levels", "of", "c-Myb", "protein", "." ]
[ 7, 8, 8, 0, 0, 0, 0, 0, 9, 10, 0 ]
6731
[ "Thus", ",", "we", "conclude", "that", "appropriate", "controls", "from", "the", "same", "individuals", ",", "such", "as", "T", "cells", "in", "the", "case", "of", "stem", "cell", "disorders", ",", "should", "always", "be", "employed", "to", "conclusively", "determine", "whether", "certain", "cells", "of", "hematopoietic", "origin", "are", "clonal", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17287
[ "Computer-assisted", "analysis", "of", "the", "deduced", "amino", "acid", "sequence", "indicates", "that", "FKBP", "exhibits", "no", "internal", "homology", "and", "does", "not", "have", "significant", "sequence", "similarity", "to", "any", "other", "amino", "acid", "sequences", "of", "known", "proteins", ",", "including", "cyclophilin", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
599
[ "The", "transcription", "factor", ",", "Nm23H2", ",", "binds", "to", "and", "activates", "the", "translocated", "c-myc", "allele", "in", "Burkitt", "'s", "lymphoma", "." ]
[ 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0 ]
2460
[ "The", "magnitude", "of", "the", "thrombin", "response", "in", "the", "different", "cell", "types", "paralleled", "the", "expression", "of", "the", "thrombin", "receptor", "mRNA", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0 ]
6628
[ "A", "site", "in", "the", "Epstein-Barr", "virus", "(", "EBV", ")", "transforming", "protein", "LMP1", "that", "constitutively", "associates", "with", "the", "tumor", "necrosis", "factor", "receptor", "1", "(", "TNFR1", ")", "-associated", "death", "domain", "protein", "TRADD", "to", "mediate", "NF-kappaB", "and", "c-Jun", "N-terminal", "kinase", "activation", "is", "critical", "for", "long-term", "lymphoblastoid", "cell", "proliferation", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 9, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 9, 0, 0, 9, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10062
[ "The", "compound", "induced", "G1", "arrest", "and", "granulocytic", "differentiation", "of", "HL-60", "cells", ",", "although", "the", "differentiation-inducing", "effect", "was", "modest", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0 ]
9154
[ "C3a", "or", "C3a", "(", "desArg", ")", "alone", "exhibited", "no", "effect", "on", "the", "expression", "or", "secretion", "of", "IL-6", "." ]
[ 9, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
15146
[ "Studies", "of", "the", "function", "of", "SCL", "suggest", "it", "is", "also", "important", "in", "proliferation", "and", "self-renewal", "events", "in", "erythroid", "cells", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
16995
[ "A", "truncated", "form", "of", "the", "product", "of", "this", "gene", "translated", "in", "vitro", "is", "a", "DNA-binding", "protein", "which", "interacts", "specifically", "with", "the", "kappa", "B", "binding", "site", "found", "in", "many", "inducible", "genes", ",", "including", "the", "enhancer", "in", "human", "immunodeficiency", "virus", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3105
[ "The", "constitutive", "association", "of", "TRAFs", "with", "LMP1", "through", "the", "aa", "187", "to", "231", "domain", "which", "is", "important", "in", "NF-kappaB", "activation", "and", "primary", "B-lymphocyte", "growth", "transformation", "implicates", "TRAF", "aggregation", "in", "LMP1", "signaling", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 9, 0, 0, 0, 7, 0, 0, 0, 9, 0, 0, 9, 0, 0 ]
113
[ "In", "contrast", ",", "NFAT", "activation", "by", "a", "G-protein-coupled", "receptor", "is", "not", "modulated", "by", "p95vav", "overexpression", ",", "suggesting", "that", "the", "effect", "is", "specific", "to", "the", "TCR", "signaling", "pathways", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
7212
[ "In", "these", "experiments", ",", "SOCS-3", "associated", "with", "Jak1", "and", "inhibited", "Jak1", "phosphorylation", ",", "and", "this", "inhibition", "was", "markedly", "enhanced", "by", "the", "presence", "of", "IL-2", "receptor", "beta", "chain", "(", "IL-2Rbeta", ")", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0 ]
3302
[ "These", "indicate", "where", "base", "order", "has", "been", "adapted", "for", "purposes", "other", "than", "stem-loop", "stability", "(", "e.g.", ",", "encoding", "proteins", "or", "gene", "regulation", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3228
[ "In", "T", "cell", "areas", ",", "p50", ",", "p52", ",", "and", "RelB", "were", "found", "in", "the", "nuclei", "of", "HLA-DR+", "cells", "with", "an", "antigen-presenting", "cell", "(", "APC", ")", "morphology", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8536
[ "Reporter", "gene", "assays", "reveal", "that", "the", "binding", "of", "c-Rel", "to", "the", "STAT5", "site", "present", "in", "the", "Fc", "gammaR1", "gene", "leads", "to", "potent", "transactivation", "of", "this", "enhancer", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0 ]
6725
[ "Clonality", "analysis", "utilizing", "X-chromosome", "inactivation", "has", "been", "used", "in", "the", "study", "of", "various", "diseases", ",", "including", "hematological", "malignancies", "." ]
[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12828
[ "Thus", ",", "although", "CD3", ",", "CD28", ",", "and", "CD2", "activate", "many", "of", "the", "same", "signaling", "molecules", ",", "they", "differed", "in", "their", "capacity", "to", "induce", "the", "tyrosine", "phosphorylation", "of", "HSI", "." ]
[ 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
6195
[ "Similar", "selective", "effects", "on", "NF-kappaB", "transcription", "are", "seen", "with", "the", "unrelated", "antioxidants", ",", "N-acetylcysteine", "(", "NAC", ")", "and", "vitamin", "C", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17806
[ "Besides", "the", "evidence", "for", "regulation", "of", "the", "expression", "of", "the", "Rap1", "protein", "in", "platelets", "from", "patients", "with", "heart", "failure", ",", "these", "findings", "constitute", "a", "new", "approach", "in", "favour", "of", "the", "regulation", "of", "platelet", "Ca2+", "transport", "through", "the", "phosphorylation", "of", "the", "Rap1", "protein", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
17706
[ "Treatment", "of", "the", "cells", "with", "ionomycin", "resulted", "in", "a", "decrease", "in", "the", "molecular", "weight", "of", "NFATp", "and", "a", "loss", "of", "32P", ",", "consistent", "with", "NFATp", "dephosphorylation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
14501
[ "This", "established", "a", "clear", "difference", "between", "both", "stimuli", ",", "indicating", "that", "Rel", "is", "the", "functionally", "active", "factor", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 0 ]
7756
[ "Of", "p38", "MAPk", "isoforms", "studied", ",", "only", "p38alpha", "and", "p38delta", "were", "detected", "in", "neutrophils", "." ]
[ 0, 9, 10, 10, 0, 0, 0, 9, 0, 9, 0, 0, 0, 7, 0 ]
13685
[ "In", "addition", ",", "ADP-activated", "platelets", "induced", "MCP-1", "and", "ICAM-1", "promoter-dependent", "transcription", "." ]
[ 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]
2733
[ "These", "simian", "EBV", "share", "considerable", "genetic", ",", "biologic", ",", "and", "epidemiologic", "features", "with", "human", "EBV", ",", "including", "virus-induced", "tumorigenesis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1465
[ "The", "first", "early-induced", "peak", "was", "transient", "and", "likely", "corresponds", "to", "the", "well", "documented", "typical", "junB", "mRNA", ",", "stimulated", "in", "response", "to", "numerous", "growth", "factors", ",", "including", "IL-6", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0 ]
3652
[ "Peripheral", "blood", "lymphocytes", "(", "PBL", ")", "and", "alloreactive", "T", "cell", "lines", "of", "two", "male", "infants", "born", "to", "consanguinous", "parents", "and", "presenting", "with", "severe", "combined", "immunodeficiency", "(", "SCID", ")", "showed", "a", "pronounced", "deficiency", "in", "T", "cell", "activation", "." ]
[ 7, 8, 8, 0, 7, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17314
[ "A", "direct", "correlation", "was", "found", "between", "the", "extent", "of", "inflammation", "and", "nuclear", "grade", "(", "P", "less", "than", "0.0001", ")", ",", "and", "an", "inverse", "correlation", "between", "inflammation", "and", "oestrogen", "receptor", "(", "OR", ")", "positivity", "(", "P", "less", "than", "0.05", ")", "as", "well", "as", "inflammation", "and", "progesterone", "receptor", "(", "PR", ")", "positivity", "(", "P", "less", "than", "0.05", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6724
[ "Clonality", "analysis", "of", "granulocytes", "and", "T", "lymphocytes", "in", "healthy", "females", "by", "the", "PCR-based", "HUMARA", "method", "." ]
[ 0, 0, 0, 7, 0, 7, 8, 0, 0, 0, 0, 0, 0, 1, 0, 0 ]
12887
[ "Our", "data", "provide", "evidence", "that", "the", "differential", "responses", "in", "gene", "expression", "and", "cell", "activation", "seen", "in", "primary", "NK", "and", "T", "cells", "on", "direct", "stimulation", "with", "different", "cytokines", "may", "be", "a", "direct", "result", "of", "distinct", "activation", "of", "STAT", "transcription", "factors", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
14073
[ "Mycobacterium", "tuberculosis", "mannose-capped", "lipoarabinomannan", "can", "induce", "NF-kappaB", "-dependent", "activation", "of", "human", "immunodeficiency", "virus", "type", "1", "long", "terminal", "repeat", "in", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 7, 8, 0 ]
12117
[ "However", ",", "the", "reasons", "for", "these", "changes", "are", "not", "clear", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12971
[ "It", "was", "proposed", "that", "the", "mechanism", "of", "antiviral", "action", "of", "S9a", "was", "on", "the", "host", "cell", ",", "by", "blocking", "TNF-alpha", "transcription", "via", "a", "Tat", "-induced", "tar-independent", "loop", ",", "which", "decreases", "downstream", "NF-kappaB", "activation", "of", "HIV-1", "long", "terminal", "repeat", "(", "LTR", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 1, 2, 2, 2, 0, 1, 0, 0 ]
17799
[ "We", "first", "found", "experimental", "conditions", "where", "Ca", "(", "2+", ")", "-transport", "by", "platelet", "membrane", "vesicles", "appeared", "to", "be", "dependent", "on", "the", "phosphorylation", "of", "the", "Rap1", "protein", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
18445
[ "Here", "we", "report", "that", "CsA", "treatment", "of", "Raji", "B", "and", "Jurkat", "T", "cell", "lines", "yields", "a", "phosphorylated", "form", "of", "NFATp", "that", "is", "inhibited", "in", "DNA-binding", "and", "in", "its", "ability", "to", "form", "an", "NFAT", "complex", "with", "Fos", "and", "Jun", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 9, 0 ]
18528
[ "Activation", "of", "the", "HIV-1", "enhancer", "by", "the", "LEF-1", "HMG", "protein", "on", "nucleosome-assembled", "DNA", "in", "vitro", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 9, 10, 10, 0, 1, 2, 0, 0, 0 ]
8363
[ "Here", ",", "we", "report", "that", "expression", "of", "FasL", "protein", "and", "mRNA", "in", "activated", "NK", "cells", "is", "also", "regulated", "by", "redox", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 3, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0 ]
1858
[ "Liposomes", "do", "not", "alter", "the", "suppressive", "action", "of", "MPL", "when", "placed", "in", "lymphocyte", "culture", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
14349
[ "The", "results", "show", "for", "the", "first", "time", "that", "a", "DNA-binding", "protein", "can", "be", "used", "for", "affinity", "purification", "of", "fusion", "proteins", "as", "exemplified", "by", "the", "specific", "and", "gentle", "recovery", "of", "beta-galactosidase", "and", "alkaline", "phosphatase", "from", "bacterial", "lysates", "using", "immunomagnetic", "separation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]
3386
[ "Induction", "of", "vascular", "cell", "adhesion", "molecule-1", "by", "low-density", "lipoprotein", "." ]
[ 0, 0, 9, 10, 10, 10, 0, 9, 10, 0 ]
14950
[ "A", "number", "of", "our", "studies", "indicate", "that", "cAMP", "is", "the", "second", "messenger", "for", "the", "effects", "of", "MM-LDL", "cited", "above", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]