id
stringlengths 1
5
| tokens
sequence | ner_tags
sequence |
---|---|---|
13608 | [
"Thus",
",",
"Fas",
"expression",
"is",
"likely",
"mediated",
"by",
"PKC",
"through",
"TDAG51",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
1,
0
] |
9184 | [
"The",
"maximal",
"stimulation",
"of",
"the",
"lymphocytes",
",",
"as",
"measured",
"by",
"the",
"maximal",
"thymidine",
"incorporation",
"(",
"in",
"the",
"absence",
"of",
"cortisol",
")",
"in",
"the",
"FMS",
"group",
"was",
"approximately",
"1.5",
"times",
"higher",
"(",
"p",
"<",
".05",
")",
"than",
"in",
"the",
"control",
"or",
"LBP",
"group",
"."
] | [
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
18447 | [
"Dephosphorylation",
"by",
"in",
"vitro",
"treatment",
"with",
"calcineurin",
"or",
"alkaline",
"phosphatase",
"restores",
"NFATp",
"DNA",
"binding",
"activity",
"and",
"its",
"ability",
"to",
"reconstitute",
"an",
"NFAT",
"complex",
"with",
"Fos",
"and",
"Jun",
"proteins",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
9,
0,
0
] |
8383 | [
"Surprisingly",
",",
"although",
"stimulation",
"of",
"Jurkat",
"T",
"cells",
"with",
"either",
"CHO-CD80",
"or",
"anti-CD28",
"mAb",
"resulted",
"in",
"robust",
"tyrosine",
"phosphorylation",
"of",
"CD28",
"itself",
",",
"ligation",
"with",
"CHO-CD86",
"was",
"unable",
"to",
"induce",
"detectable",
"CD28",
"tyrosyl",
"phosphorylation",
"over",
"a",
"range",
"of",
"stimulation",
"conditions",
"."
] | [
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
9,
0,
9,
10,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1863 | [
"Inhibition",
"effects",
"versus",
"time",
"were",
"described",
"by",
"a",
"pharmacodynamic",
"model",
"using",
"MPL",
"concentrations",
"in",
"plasma",
"as",
"an",
"input",
"function",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0
] |
18458 | [
"Interestingly",
",",
"Oct1",
"and",
"NF-AT",
"DNA",
"binding",
"activity",
"were",
"not",
"affected",
"by",
"cysteamine",
"treatment",
",",
"suggesting",
"that",
"oxidative",
"signalling",
"processes",
"operate",
"in",
"a",
"selective",
"manner",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
13945 | [
"Furthermore",
",",
"HL-60",
"cells",
"transduced",
"with",
"a",
"bcl-2",
"expression",
"vector",
"showed",
"the",
"same",
"differentiation",
"response",
"to",
"retinoids",
"as",
"did",
"parental",
"HL-60",
"cells",
"even",
"though",
"apoptosis",
"was",
"inhibited",
"in",
"these",
"bcl-2-transduced",
"cells",
",",
"suggesting",
"that",
"differentiation",
"and",
"apoptosis",
"are",
"regulated",
"independently",
"in",
"myeloid",
"leukemic",
"cells",
"."
] | [
0,
0,
5,
6,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0
] |
6524 | [
"AP-1",
"but",
"not",
"NF-IL-6",
"DNA",
"binding",
"activity",
"was",
"also",
"detected",
"in",
"C5a-stimulated",
"PBMC",
";",
"however",
",",
"its",
"delayed",
"expression",
"(",
"maximal",
"at",
"4",
"hours",
")",
"suggested",
"a",
"less",
"important",
"role",
"in",
"the",
"rapid",
"production",
"of",
"IL-8",
"."
] | [
9,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
11021 | [
"Isolated",
"thymic",
"T",
"cells",
"from",
"the",
"transgenic",
"mice",
"also",
"show",
"a",
"dramatically",
"decreased",
"survival",
"rate",
"when",
"evaluated",
"in",
"culture",
"under",
"conditions",
"that",
"do",
"not",
"favor",
"activation",
"."
] | [
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
14202 | [
"Transcriptional",
"activation",
"of",
"the",
"macrophage",
"colony-stimulating",
"factor",
"gene",
"by",
"IL-2",
"is",
"associated",
"with",
"secretion",
"of",
"bioactive",
"macrophage",
"colony-stimulating",
"factor",
"protein",
"by",
"monocytes",
"and",
"involves",
"activation",
"of",
"the",
"transcription",
"factor",
"NF-kappa",
"B",
"."
] | [
0,
0,
0,
0,
1,
2,
2,
2,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
7,
0,
0,
0,
0,
0,
9,
10,
9,
10,
0
] |
12813 | [
"These",
"results",
"collectively",
"reveal",
"a",
"complex",
"interaction",
"of",
"STAT5",
"with",
"other",
"signaling",
"pathways",
"and",
"illustrate",
"that",
"regulation",
"of",
"gene",
"expression",
"requires",
"integration",
"of",
"opposing",
"signals"
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1399 | [
"Within",
"this",
"region",
"we",
"have",
"identified",
"a",
"gene",
"coding",
"for",
"a",
"1.3-kb",
"transcript",
",",
"expressed",
"only",
"in",
"restricted",
"subsets",
"of",
"cells",
"within",
"the",
"lymphoid",
"lineage",
"and",
"expressed",
"at",
"high",
"levels",
"in",
"leukemic",
"cells",
"carrying",
"a",
"t",
"(",
"14",
";",
"14",
")",
"(",
"q11",
";",
"q32",
")",
"chromosome",
"translocation",
"or",
"a",
"inv",
"(",
"14",
")",
"(",
"q11",
";",
"q32",
")",
"chromosome",
"inversion",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5533 | [
"Surface",
"expression",
"of",
"CD23",
"was",
"determined",
"by",
"FACS",
"analysis",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
13511 | [
"The",
"Epstein-Barr",
"virus",
"Rta",
"protein",
"activates",
"lytic",
"cycle",
"genes",
"and",
"can",
"disrupt",
"latency",
"in",
"B",
"lymphocytes",
"."
] | [
0,
9,
10,
10,
10,
0,
1,
2,
2,
0,
0,
0,
0,
0,
7,
8,
0
] |
4348 | [
"Many",
"of",
"Pb",
"'s",
"effects",
"on",
"the",
"immune",
"system",
"could",
"be",
"explained",
"through",
"activation",
"of",
"the",
"transcription",
"factor",
",",
"NF-kappa",
"B",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
10,
0
] |
17963 | [
"Absorptive",
"hypercalciuria",
"(",
"a",
"stone-forming",
"condition",
")",
"is",
"characterized",
"by",
"gut",
"hyperabsorption",
"of",
"calcium",
",",
"hypercalciuria",
",",
"and",
"reduced",
"bone",
"density",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
18455 | [
"Taking",
"the",
"IL-2",
"gene",
"as",
"a",
"candidate",
",",
"we",
"examined",
"the",
"effect",
"of",
"cysteamine",
"treatment",
"on",
"early",
"gene",
"expression",
"during",
"lymphocyte",
"activation",
",",
"and",
"on",
"the",
"activity",
"of",
"transcription",
"factors",
"AP-1",
",",
"NF-kappa",
"B",
",",
"NF-AT",
"and",
"Oct1",
",",
"whose",
"functions",
"are",
"required",
"for",
"expression",
"of",
"the",
"IL-2",
"mRNA",
"."
] | [
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
9,
0,
9,
10,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
7340 | [
"TNF",
"mRNA",
"expression",
"induced",
"by",
"LPS",
"was",
"decreased",
"when",
"the",
"pre-treatment",
"of",
"PBMC",
"with",
"IL-10",
"was",
"performed",
"on",
"plastic",
",",
"whereas",
"this",
"was",
"not",
"the",
"case",
"when",
"cells",
"were",
"pre-cultured",
"with",
"IL-10",
"on",
"Teflon",
"."
] | [
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0
] |
16469 | [
"Comparison",
"of",
"the",
"sequences",
"of",
"all",
"elements",
"recognized",
"by",
"TCF-1",
"defines",
"a",
"consensus",
"motif",
"A/T",
"A/T",
"C",
"A",
"A/G",
"A",
"G",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
0,
0,
9,
0,
0,
1,
2,
1,
2,
2,
2,
2,
2,
2,
0
] |
4566 | [
"In",
"addition",
",",
"IL-13",
"phosphorylated",
"insulin",
"response",
"substrate-1",
",",
"IL-4R",
"p140",
",",
"JAK1",
",",
"and",
"Tyk2",
",",
"but",
"not",
"JAK3",
"kinase",
"."
] | [
0,
0,
0,
9,
0,
9,
10,
10,
0,
9,
10,
0,
9,
0,
0,
9,
0,
0,
0,
9,
10,
0
] |
11596 | [
"We",
"reported",
"here",
"that",
"the",
"E1B",
"19K",
"mutant",
"viruses",
"were",
"unable",
"to",
"replicate",
"efficiently",
"in",
"a",
"monocyte",
"cell",
"line",
",",
"U937",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
5,
0
] |
16099 | [
"Deletion",
"of",
"all",
"the",
"Sp",
"1-binding",
"sites",
"from",
"the",
"enhancer",
"reduces",
"transcription",
"by",
"80-90",
"%",
"in",
"HeLa",
",",
"as",
"well",
"as",
"in",
"BJA-B",
"cells",
",",
"whereas",
"the",
"removal",
"of",
"the",
"octamer-binding",
"site",
"reduces",
"transcription",
"to",
"levels",
"below",
"detection",
"in",
"both",
"cell",
"types",
"."
] | [
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
9482 | [
"Cyclosporin",
"A",
"(",
"CsA",
")",
"may",
"achieve",
"its",
"immunosuppressive",
"effects",
"by",
"inhibiting",
"the",
"calcium-",
"and",
"calmodulin-dependent",
"phosphatase",
"calcineurin",
"which",
"is",
"required",
"for",
"activation",
"of",
"target",
"genes",
"by",
"members",
"of",
"the",
"NFAT",
"(",
"nuclear",
"factor",
"of",
"activated",
"T",
"cells",
")",
"transcription",
"factor",
"family",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
9,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
10,
10,
10,
10,
10,
0
] |
16549 | [
"Thus",
",",
"each",
"factor",
"may",
"function",
"as",
"a",
"novel",
"negative",
"regulator",
"of",
"transcription",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0
] |
7368 | [
"Using",
"Northern",
"blotting",
",",
"RNase",
"protection",
"assay",
",",
"and",
"nuclear",
"run-on",
"analyses",
",",
"we",
"show",
"that",
"the",
"up-regulation",
"of",
"ASM",
"expression",
"is",
"regulated",
"mainly",
"at",
"the",
"level",
"of",
"transcription",
"and",
"that",
"new",
"protein",
"synthesis",
"is",
"required",
"for",
"enhanced",
"ASM",
"activity",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
4811 | [
"The",
"binding",
"activity",
"of",
"transcription",
"factor",
"AP-1",
",",
"which",
"consists",
"of",
"dimers",
"of",
"Fos",
"and",
"Jun",
"family",
"proteins",
",",
"was",
"also",
"studied",
"using",
"a",
"gel",
"shift",
"assay",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3156 | [
"It",
"also",
"suggests",
"a",
"novel",
"specificity-conferring",
"mechanism",
"for",
"mineralocorticoid",
"action",
"at",
"the",
"membrane",
"level",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17093 | [
"Phorbol",
"ester",
"or",
"specific",
"antigen",
"recognition",
"induced",
"HIV",
"LTR",
"transactivation",
",",
"whereas",
"stimulation",
"with",
"tumor",
"necrosis",
"factor",
"or",
"antibody",
"to",
"CD3",
"did",
"not",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
9,
0,
0,
0
] |
7882 | [
"SIT",
"is",
"a",
"disulfide-linked",
"homodimeric",
"glycoprotein",
"that",
"is",
"expressed",
"in",
"lymphocytes",
"."
] | [
9,
0,
0,
9,
10,
10,
0,
0,
0,
0,
7,
0
] |
4839 | [
"We",
"identified",
"a",
"region",
"of",
"the",
"c-myb",
"5",
"'",
"flanking",
"sequence",
"that",
"increased",
"c-myb",
"expression",
"during",
"T-cell",
"activation",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
1,
0,
0,
0,
0,
0
] |
10102 | [
"Potential",
"cis-acting",
"elements",
"were",
"identified",
"in",
"the",
"promoter",
"region",
"of",
"the",
"NGAL",
"gene",
"by",
"computer",
"analysis",
"and",
"include",
"binding",
"sites",
"for",
"CTF/CBP",
",",
"the",
"hematopoietic",
"transcription",
"factors",
"GATA-1",
"and",
"PU.1",
",",
"and",
"the",
"LPS-inducible",
"factor",
"NF-kappa",
"B",
"."
] | [
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
9,
0,
0,
9,
10,
10,
9,
0,
9,
0,
0,
0,
9,
10,
10,
10,
0
] |
13912 | [
"In",
"this",
"review",
"we",
"describe",
"the",
"defects",
"in",
"B-",
"and",
"T-",
"lymphocyte",
"development",
"in",
"mice",
"carrying",
"targeted",
"mutations",
"in",
"the",
"E-protein",
"genes",
"and",
"discuss",
"our",
"current",
"understanding",
"of",
"the",
"role",
"of",
"these",
"proteins",
"in",
"lymphoid",
"development"
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5749 | [
"In",
"addition",
",",
"T",
"cell",
"proliferation",
"was",
"completely",
"resistant",
"to",
"the",
"actions",
"of",
"the",
"immunosuppressant",
"cyclosporin",
"A",
"(",
"CsA",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
6297 | [
"In",
"the",
"present",
"study",
",",
"by",
"using",
"an",
"in",
"vitro",
"model",
",",
"we",
"examined",
"whether",
"stimulation",
"with",
"interleukin-6",
"(",
"IL-6",
")",
",",
"an",
"immunoregulatory",
",",
"multipotential",
"cytokine",
",",
"modulates",
"the",
"expression",
"and",
"activities",
"of",
"the",
"MSR",
"in",
"macrophages",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
9,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
7,
0
] |
3052 | [
"In",
"addition",
",",
"we",
"identify",
"a",
"major",
"PB1",
"nuclear",
"protein-binding",
"complex",
"that",
"is",
"not",
"present",
"in",
"resting",
"peripheral",
"blood",
"T",
"cells",
"but",
"is",
"rapidly",
"induced",
"following",
"T-cell",
"activation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
7,
8,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0
] |
7442 | [
"Concanavalin",
"A-activated",
"cycling",
"T",
"cell",
"blasts",
"from",
"mice",
"that",
"are",
"transgenic",
"for",
"the",
"dominant",
"IkappaB",
"molecule",
"have",
"increased",
"sensitivity",
"to",
"Fas-mediated",
"apoptosis",
",",
"associated",
"with",
"a",
"down-regulation",
"of",
"NF-kappaB",
"complexes",
"in",
"the",
"nucleus",
"."
] | [
0,
0,
5,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0
] |
13205 | [
"Degenerate",
"primers",
"corresponding",
"to",
"the",
"TFIIIA",
"zinc-finger",
"consensus",
"amino",
"acid",
"sequences",
"and",
"to",
"the",
"POU-homeodomain",
"and",
"POU-specific",
"domain",
"were",
"used",
"to",
"amplify",
"genes",
"on",
"the",
"basis",
"that",
"they",
"contained",
"similarities",
"in",
"structural",
"motifs",
"shared",
"within",
"these",
"families",
"of",
"transcription",
"factors",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
9,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
6717 | [
"Resistance",
"to",
"tumor",
"necrosis",
"factor",
"induced",
"apoptosis",
"in",
"vitro",
"correlates",
"with",
"high",
"metastatic",
"capacity",
"of",
"cells",
"in",
"vivo",
"."
] | [
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
10161 | [
"In",
"Jurkat",
"T",
"cells",
",",
"induction",
"of",
"PIF",
"DNA",
"binding",
"activity",
"was",
"rapidly",
"induced",
",",
"required",
"de",
"novo",
"protein",
"synthesis",
",",
"and",
"was",
"sustained",
"at",
"a",
"high",
"level",
"for",
"at",
"least",
"23",
"h",
"."
] | [
0,
5,
6,
6,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12352 | [
"Immunoprecipitation",
"analysis",
"revealed",
"that",
"unde3r",
"these",
"circumstances",
",",
"Calphostin",
"C",
"inhibited",
"the",
"production",
"of",
"IL-1beta",
"protein",
",",
"whereas",
"Staurosporine",
"allowed",
"protein",
"production",
",",
"but",
"inhibited",
"its",
"secretion",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11681 | [
"V3-BH10",
",",
"which",
"consists",
"of",
"42",
"amino",
"acids",
"and",
"has",
"a",
"loop",
"structure",
",",
"suppressed",
"IL-2",
"-driven",
"proliferation",
"of",
"all",
"IL-2-dependent",
"cells",
"[",
"Kit225",
",",
"ED-40515",
"(",
"+",
")",
",",
"KT-3",
",",
"7-day",
"PHA-blasts",
",",
"and",
"fresh",
"peripheral",
"blood",
"mononuclear",
"cells",
"]",
"tested",
",",
"whereas",
"it",
"did",
"not",
"suppress",
"the",
"cell",
"growth",
"of",
"IL-2-independent",
"cell",
"lines",
"(",
"Hut102",
",",
"Molt-4",
",",
"and",
"Jurkat",
")",
"."
] | [
9,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
9,
10,
0,
0,
9,
0,
0,
0,
0,
5,
6,
0,
5,
0,
5,
6,
6,
6,
0,
5,
0,
5,
6,
0,
0,
7,
8,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
5,
0,
5,
0,
0,
5,
0,
0
] |
5515 | [
"Pretreatment",
"with",
"the",
"broad",
"serine/threonine",
"kinase",
"inhibitor",
"staurosporine",
"partly",
"blocked",
"the",
"calyculin",
"A",
"-induced",
"STAT3",
"phosphorylation",
",",
"whereas",
"inhibitors",
"of",
"serine/threonine",
"kinases",
",",
"such",
"as",
"mitogen-activated",
"protein",
"kinase-1",
"extracellular-regulated",
"kinase-kinase",
",",
"mitogen-activated",
"protein",
"p38",
"kinase",
",",
"and",
"phosphatidylinositol",
"3-kinase",
",",
"did",
"not",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
9,
10,
10,
10,
10,
0,
9,
10,
10,
10,
0,
0,
9,
10,
0,
0,
0,
0
] |
13972 | [
"In",
"both",
"types",
"of",
"donors",
",",
"the",
"effect",
"of",
"IL-13",
"on",
"IL-2",
"-induced",
"IFN-gamma",
"production",
"was",
"in",
"marked",
"contrast",
"to",
"the",
"strong",
"inhibition",
"seen",
"with",
"IL-4",
"in",
"NK",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
7,
8,
0
] |
2990 | [
"C3/5",
"cells",
"developed",
"specific",
"proliferation",
"and",
"cytotoxicity",
"when",
"challenged",
"with",
"peptide-pulsed",
"lymphoblastic",
"cell",
"lines",
"and",
"peripheral",
"blood",
"lymphocytes",
"from",
"the",
"four",
"DR11",
"(",
"+",
")",
"APL",
"patients",
"."
] | [
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3917 | [
"Deranged",
"cellular",
"cholesterol",
"homeostasis",
"has",
"been",
"widely",
"recognized",
"in",
"the",
"initiation",
"as",
"well",
"as",
"progression",
"of",
"various",
"types",
"of",
"cancers",
"including",
"chronic",
"myeloid",
"leukaemia",
"(",
"CML",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
10851 | [
"Taken",
"together",
",",
"these",
"data",
"demonstrate",
"the",
"existence",
"of",
"an",
"HLA-DQ",
"isotype-specific",
"trans-acting",
"factor",
",",
"which",
"functions",
"independently",
"of",
"CIITA",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
9,
0
] |
12116 | [
"Similar",
"results",
"have",
"been",
"obtained",
"by",
"our",
"own",
"group",
"in",
"peripheral",
"blood",
"mononuclear",
"cells",
"(",
"PBMC",
")",
"from",
"patients",
"with",
"secondary",
"hyperparathyroidism",
"to",
"chronic",
"renal",
"failure",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2836 | [
"Treatment",
"of",
"Jurkat",
"cells",
"with",
"mAb",
"J393",
"induced",
"tyrosine",
"phosphorylation",
"of",
"specific",
"protein",
"substrates",
"that",
"underwent",
"hyperphosphorylation",
"upon",
"antigen",
"receptor",
"costimulation",
"."
] | [
0,
0,
5,
6,
0,
9,
10,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
9,
10,
0,
0
] |
10772 | [
"The",
"third",
"site",
"was",
"occupied",
"in",
"quiescent",
"cells",
"or",
"in",
"cells",
"stimulated",
"by",
"anti",
"CD2",
"or",
"anti",
"CD28",
"alone",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
10,
0,
0
] |
15689 | [
"PMA-induced",
"CD4",
"down-modulation",
"occurred",
"normally",
"."
] | [
0,
9,
0,
0,
0,
0
] |
3118 | [
"The",
"gene",
"encoding",
"the",
"Epstein-Barr",
"virus",
"(",
"EBV",
")",
"-specific",
"dUTPase",
"was",
"amplified",
"from",
"virus",
"DNA",
"by",
"PCR",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
0,
0,
0,
1,
2,
0,
0,
0
] |
7482 | [
"Retinoidal",
"antagonists",
"and",
"potential",
"agonists",
"."
] | [
0,
0,
0,
0,
0,
0
] |
6388 | [
"This",
"study",
"compared",
"the",
"effect",
"of",
"these",
"stimuli",
"on",
"endogenous",
"IkappaB",
"kinase",
"(",
"IKK",
")",
"signalsome",
"activation",
"and",
"IkappaB",
"phosphorylation/proteolysis",
"in",
"human",
"monocytic",
"cells",
"and",
"investigated",
"the",
"role",
"of",
"the",
"signalsome",
"proteins",
"IKK-alpha",
",",
"IKK-beta",
",",
"NF-kappaB-inducing",
"kinase",
"(",
"NIK",
")",
",",
"IKK-gamma",
"(",
"NF-kappaB",
"essential",
"modulator",
")",
",",
"and",
"IKK",
"complex-associated",
"protein",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
9,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
9,
10,
9,
0,
9,
0,
9,
10,
0,
9,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
15758 | [
"The",
"endothelium",
"plays",
"a",
"critical",
"role",
"in",
"inflammation",
"by",
"directing",
"circulating",
"leukocytes",
"into",
"extravascular",
"tissues",
"by",
"expressing",
"adhesive",
"molecules",
"for",
"leukocytes",
"[",
"e.g.",
",",
"endothelial-leukocyte",
"adhesion",
"molecule",
"1",
"(",
"ELAM-1",
")",
"and",
"intercellular",
"adhesion",
"molecule",
"1",
"(",
"ICAM-1",
")",
"]",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
9,
10,
0,
7,
0,
0,
0,
9,
10,
10,
10,
0,
9,
0,
0,
9,
10,
10,
10,
0,
9,
0,
0,
0
] |
7364 | [
"It",
"was",
"postulated",
"that",
"this",
"NF-kappaB-regulated",
"promoter",
"might",
"play",
"a",
"role",
"in",
"the",
"activation",
"of",
"the",
"accessory",
"cells",
"as",
"well",
"as",
"the",
"rate",
"of",
"replication",
"of",
"HIV-1",
"in",
"monocyte-derived",
"macrophages",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
825 | [
"Transcriptional",
"activity",
"of",
"core",
"binding",
"factor-alpha",
"(",
"AML1",
")",
"and",
"beta",
"subunits",
"on",
"murine",
"leukemia",
"virus",
"enhancer",
"cores",
"."
] | [
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
10,
0,
0,
1,
2,
2,
2,
2,
0
] |
12461 | [
"In",
"addition",
",",
"both",
"heat",
"and",
"cadmium",
"produced",
"an",
"increase",
"in",
"the",
"amount",
"of",
"the",
"intermediate",
"filament",
"protein",
"vimentin",
",",
"as",
"determined",
"by",
"immunoblot",
"and",
"immunofluorescence",
"assays",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
563 | [
"The",
"normal",
"cell",
"cycle",
"is",
"regulated",
"by",
"several",
"molecules",
",",
"such",
"as",
"the",
"tumor-suppressor",
"protein",
"pRb",
",",
"the",
"G1",
"cyclins",
",",
"the",
"cyclin-dependent",
"kinases",
",",
"and",
"their",
"inhibitors",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
9,
10,
0,
0,
9,
10,
0,
0,
0,
0,
0
] |
17848 | [
"Therefore",
",",
"HIV-1-induced",
"cell",
"fusion",
"brings",
"together",
"factors",
"that",
"upregulate",
"virus",
"transcription",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
9213 | [
"The",
"OCA-B",
"and",
"VP16",
"interactions",
"with",
"the",
"Oct-1",
"POU",
"domain",
"are",
"sufficiently",
"different",
"to",
"permit",
"OCA-B",
"and",
"VP16",
"to",
"bind",
"the",
"Oct-1",
"POU",
"domain",
"simultaneously",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
9,
10,
10,
0,
0
] |
17226 | [
"Two",
"kappa",
"B-like",
"motifs",
"at",
"positions",
"-98",
"to",
"-108",
"of",
"the",
"GM-CSF",
"promoter",
"were",
"also",
"recognized",
"but",
"with",
"much",
"lower",
"affinities",
"."
] | [
0,
1,
2,
2,
0,
1,
2,
2,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2157 | [
"Retinoid-like",
"receptors",
"play",
"a",
"central",
"role",
"in",
"hormonal",
"responses",
"by",
"forming",
"heterodimers",
"with",
"other",
"nuclear",
"hormone",
"receptors",
"."
] | [
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
9,
10,
10,
0
] |
5641 | [
"Body",
"weight",
",",
"body",
"mass",
"index",
",",
"body",
"fat",
",",
"lean",
"body",
"mass",
",",
"blood-glucose",
",",
"cholesterol",
",",
"HDL-cholesterol",
",",
"triglyceride",
",",
"beta-lipoproteins",
",",
"insulin",
",",
"gonadotropin",
",",
"estradiol",
",",
"testosterone",
",",
"SHBG",
",",
"T3",
",",
"T4",
"and",
"TSH",
"levels",
"as",
"well",
"as",
"estradiol",
"and",
"progesterone",
"receptor",
"levels",
"in",
"excised",
"tumor",
"were",
"studied",
"in",
"40",
"patients",
"with",
"breast",
"cancer",
"prior",
"to",
"conservative",
"treatment",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
9236 | [
"High-level",
"NF-kappaB",
"activation",
"also",
"appears",
"to",
"be",
"a",
"critical",
"component",
"of",
"long-term",
"outgrowth",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
10162 | [
"Interestingly",
",",
"PIF",
"was",
"constitutively",
"activated",
"in",
"human",
"T-cell",
"leukemia",
"virus",
"type",
"1-transformed",
"MT-2",
"cells",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
5,
6,
6,
6,
6,
6,
6,
6,
0
] |
13903 | [
"AF-10",
"was",
"involved",
"in",
"5",
"of",
"6",
"evaluable",
"cases",
",",
"including",
"1",
"case",
"without",
"detectable",
"CALM",
"or",
"MLL",
"rearrangement",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0
] |
5809 | [
"The",
"HIV-mediated",
"NF-kappa",
"B",
"activation",
"is",
"selectively",
"reduced",
"by",
"AO",
"to",
"PKC-zeta",
"."
] | [
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
13058 | [
"Finally",
",",
"it",
"would",
"be",
"useful",
"to",
"know",
"what",
"the",
"inhibitory",
"effects",
"of",
"CyA",
"are",
"on",
"tolerance",
"and",
"negative",
"regulatory",
"events",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
6802 | [
"Our",
"results",
"demonstrated",
"that",
":",
"(",
"i",
")",
"PGN",
"induced",
"phosphorylation",
"of",
"the",
"transcription",
"factors",
"ATF-1",
"and",
"CREB",
";",
"(",
"ii",
")",
"ATF-1",
"and",
"CREB",
"bound",
"DNA",
"as",
"a",
"dimer",
"and",
"induced",
"transcriptional",
"activation",
"of",
"a",
"CRE",
"reporter",
"plasmid",
",",
"which",
"was",
"inhibited",
"by",
"dominant",
"negative",
"CREB",
"and",
"ATF-1",
";",
"(",
"iii",
")",
"PGN",
"induced",
"phosphorylation",
"of",
"c-Jun",
",",
"protein",
"synthesis",
"of",
"JunB",
"and",
"c-Fos",
",",
"and",
"transcriptional",
"activation",
"of",
"the",
"AP-1",
"reporter",
"plasmid",
",",
"which",
"was",
"inhibited",
"by",
"dominant",
"negative",
"c-Fos",
";",
"and",
"(",
"iv",
")",
"PGN-induced",
"activation",
"of",
"CREB/ATF",
"and",
"AP-1",
"was",
"mediated",
"through",
"CD14",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
9,
0,
9,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
9,
0
] |
17371 | [
"Although",
"the",
"TCE",
"is",
"similar",
"in",
"sequence",
"to",
"a",
"consensus",
"NF",
"kappa",
"B",
"site",
",",
"several",
"criteria",
"indicate",
"that",
"TCF-1",
"is",
"distinct",
"from",
"NF",
"kappa",
"B",
"."
] | [
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
10,
10,
0
] |
17252 | [
"This",
"differentiation",
"is",
"accompanied",
"by",
"an",
"augmented",
"capacity",
"to",
"generate",
"growth",
"factors",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
3170 | [
"METHOD",
"."
] | [
0,
0
] |
13665 | [
"In",
"contrast",
",",
"induction",
"of",
"differentiation",
"but",
"not",
"of",
"proliferation",
"was",
"followed",
"by",
"a",
"25-",
"to",
"30-fold",
"increase",
"in",
"the",
"nuclear",
"level",
"of",
"the",
"tumor",
"suppressor",
"proteins",
"p53",
"(",
"wild",
"type",
")",
",",
"pRb",
",",
"and",
"p130/Rb2",
"and",
"of",
"the",
"p53-dependent",
"cyclin",
"kinase",
"inhibitor",
"p21/Cip1",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
9,
0,
0,
9,
0,
0,
0,
9,
10,
10,
10,
9,
0
] |
9396 | [
"The",
"functions",
"of",
"basic",
"helix-loop-helix",
"(",
"bHLH",
")",
"transcription",
"factors",
"in",
"activating",
"differentiation-linked",
"gene",
"expression",
"and",
"in",
"inducing",
"G1",
"cell",
"cycle",
"arrest",
"are",
"negatively",
"regulated",
"by",
"members",
"of",
"the",
"Id",
"family",
"of",
"HLH",
"proteins",
"."
] | [
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
0
] |
6458 | [
"C/EBP",
"beta",
"was",
"detected",
"in",
"the",
"synovial",
"lining",
"and",
"in",
"sublining",
"cells",
"of",
"synovial",
"tissue",
"from",
"patients",
"with",
"both",
"rheumatoid",
"and",
"osteoarthritis",
"."
] | [
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0
] |
10826 | [
"The",
"methodology",
"employed",
"transient",
"transfection",
"of",
"HEK",
"293",
"cells",
"with",
"a",
"cDNA",
"for",
"the",
"52-kDa",
"form",
"of",
"G",
"(",
"S",
")",
"alpha",
"under",
"regulation",
"by",
"inducible",
"metallothionein",
"promoters",
"."
] | [
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
0,
0,
0,
1,
2,
2,
0
] |
1795 | [
"Murine",
"B",
"lymphocytes",
",",
"adipocytes",
",",
"and",
"olfactory",
"neurons",
"contain",
"a",
"DNA-binding",
"protein",
"that",
"participates",
"in",
"the",
"regulation",
"of",
"genes",
"encoding",
"tissue-specific",
"components",
"of",
"signal",
"transduction",
"."
] | [
7,
8,
8,
0,
7,
0,
0,
7,
8,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0
] |
9103 | [
"We",
"examined",
"33",
"patients",
"with",
"diabetes",
"mellitus",
"(",
"Type",
"I",
"and",
"Type",
"II",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
10089 | [
"RESULTS",
":",
"Neutrophil",
"adhesion",
"to",
"cultured",
"corneal",
"endothelial",
"cells",
"increased",
"significantly",
"on",
"exposure",
"to",
"TNFalpha",
"(",
"451.4+/-45.4",
"cells/mm2",
",",
"n",
"=",
"16",
")",
"compared",
"to",
"control",
"(",
"156.7+/-27.3",
"cells/mm2",
",",
"n",
"=",
"16",
",",
"P",
"<",
"0.01",
")",
"."
] | [
0,
0,
0,
0,
0,
5,
6,
6,
6,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16106 | [
"In",
"extracts",
"of",
"induced",
",",
"Il-2",
"secreting",
"El4",
"cells",
"three",
"individual",
"protein",
"factors",
"bind",
"to",
"TCEd",
"DNA",
"."
] | [
0,
0,
0,
0,
0,
5,
6,
6,
6,
0,
0,
9,
10,
0,
0,
1,
2,
0
] |
3475 | [
"The",
"mode",
"of",
"glucocorticoid",
"action",
"after",
"administration",
"of",
"such",
"megadoses",
"is",
"inexplicable",
"up",
"to",
"now",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16161 | [
"The",
"kappa",
"B",
"sequence",
"(",
"GGGACTTTCC",
")",
"binds",
"a",
"factor",
",",
"NF-kappa",
"B",
",",
"that",
"is",
"constitutively",
"found",
"in",
"its",
"functional",
",",
"DNA",
"binding",
"form",
"only",
"in",
"B",
"lymphocytes",
"."
] | [
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
9859 | [
"This",
"review",
"will",
"cover",
"the",
"molecular",
"mechanisms",
"that",
"are",
"utilized",
"by",
"mammalian",
"oncogenic",
"viruses",
"to",
"affect",
"the",
"activity",
"of",
"Rel/NF-kappa",
"B",
"transcription",
"factors",
"and",
"the",
"role",
"of",
"Rel/NF-kappa",
"B",
"in",
"the",
"regulation",
"of",
"viral",
"gene",
"expression",
"and",
"replication",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
9,
10,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1110 | [
"Human",
"cDNAs",
"encoding",
"Kruppel-type",
"zinc",
"finger",
"domains",
",",
"designated",
"KOX",
"1-32",
",",
"have",
"been",
"cloned",
"from",
"human",
"T",
"lymphocyte",
"cell",
"line",
"libraries",
"."
] | [
1,
2,
0,
9,
10,
10,
10,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0
] |
1903 | [
"The",
"P",
"sequence",
"of",
"the",
"human",
"interleukin-4",
"(",
"IL-4",
")",
"gene",
",",
"which",
"was",
"defined",
"as",
"a",
"responsive",
"element",
"for",
"phorbol",
"12-myristate",
"13-acetate",
"and",
"calcium",
"ionophore",
"(",
"A23187",
")",
"in",
"Jurkat",
"T",
"cells",
",",
"shares",
"sequence",
"similarity",
"with",
"the",
"NF-kappa",
"B",
"and",
"the",
"NF-AT",
"binding",
"sites",
"."
] | [
0,
1,
2,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
0
] |
7423 | [
"In",
"the",
"nucleus",
",",
"it",
"functions",
"as",
"a",
"dimerization",
"cofactor",
"of",
"HNF1",
"and",
"increases",
"the",
"transcriptional",
"activity",
"of",
"HNF1",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
9,
0
] |
9577 | [
"Using",
"antibodies",
"in",
"an",
"electrophoretic",
"mobility",
"supershift",
"assay",
",",
"one",
"of",
"these",
"complexes",
"was",
"shown",
"to",
"contain",
"NF-kappa",
"B1",
"and",
"RelA",
",",
"and",
"to",
"bind",
"with",
"higher",
"affinity",
"to",
"the",
"consensus",
"kappa",
"B",
"site",
"in",
"the",
"HIV",
"long",
"terminal",
"repeat",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
1,
2,
2,
2,
0
] |
10958 | [
"In",
"contrast",
",",
"released",
"TNF-alpha",
"was",
"not",
"responsible",
"for",
"the",
"homotypic",
"aggregation",
"of",
"Ri-I",
",",
"Ci-I",
",",
"Sc-I",
",",
"and",
"Raji",
"cells",
"induced",
"by",
"mAb",
"L243",
",",
"and",
"it",
"did",
"not",
"affect",
"the",
"proliferation",
"of",
"B",
"cells",
"investigated",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
5,
0,
5,
0,
0,
5,
6,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0
] |
14807 | [
"Thus",
",",
"autoreactive",
"T-cells",
"identify",
"a",
"novel",
"antigen",
",",
"p38",
"jun-B",
",",
"in",
"IDDM",
"and",
"appear",
"to",
"indicate",
"subjects",
"at",
"risk",
"for",
"the",
"development",
"of",
"clinical",
"disease",
"."
] | [
0,
0,
7,
8,
0,
0,
9,
10,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3064 | [
"The",
"other",
"two",
"SR",
"patients",
"had",
"an",
"abnormally",
"low",
"GR",
"number",
"with",
"normal",
"binding",
"affinity",
"that",
"was",
"not",
"limited",
"to",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
10304 | [
"The",
"immunoregulatory",
"properties",
"of",
"prolactin",
",",
"a",
"pituitary",
"peptide",
"hormone",
",",
"have",
"received",
"renewed",
"attention",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
9486 | [
"Using",
"a",
"sensitive",
",",
"reverse",
"transcription-polymerase",
"chain",
"reaction",
"(",
"RT-PCR",
")",
"assay",
",",
"G0S2",
"mRNA",
"levels",
"were",
"assayed",
"in",
"cultured",
"blood",
"mononuclear",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
5,
6,
6,
6,
0
] |
13382 | [
"Insulin",
"dose-dependently",
"increased",
"the",
"PI-3",
",",
"4",
",",
"5-P3",
"production",
"but",
"YM268",
"had",
"no",
"significant",
"effect",
"on",
"the",
"insulin-dependent",
"and",
"-independent",
"PI",
"3-kinase",
"activation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
10424 | [
"We",
"here",
"report",
"that",
"(",
"i",
")",
"like",
"PML-RAR",
"alpha",
"expression",
",",
"PLZF-RAR",
"alpha",
"expression",
"blocks",
"terminal",
"differentiation",
"of",
"hematopoietic",
"precursor",
"cell",
"lines",
"(",
"U937",
"and",
"HL-60",
")",
"in",
"response",
"to",
"different",
"stimuli",
"(",
"vitamin",
"D3",
",",
"transforming",
"growth",
"factor",
"beta1",
",",
"and",
"dimethyl",
"sulfoxide",
")",
";",
"(",
"ii",
")",
"PML-RAR",
"alpha",
",",
"but",
"not",
"PLZF-RAR",
"alpha",
",",
"increases",
"RA",
"sensitivity",
"of",
"hematopoietic",
"precursor",
"cells",
"and",
"restores",
"RA",
"sensitivity",
"of",
"RA-resistant",
"hematopoietic",
"cells",
";",
"(",
"iii",
")",
"PML-RAR",
"alpha",
"and",
"PLZF-RAR",
"alpha",
"have",
"similar",
"RA",
"binding",
"affinities",
";",
"and",
"(",
"iv",
")",
"PML-RAR",
"alpha",
"enhances",
"the",
"RA",
"response",
"of",
"RA",
"target",
"genes",
"(",
"those",
"for",
"RAR",
"beta",
",",
"RAR",
"gamma",
",",
"and",
"transglutaminase",
"type",
"II",
"[",
"TGase",
"]",
")",
"in",
"vivo",
",",
"while",
"PLZF-RAR",
"alpha",
"expression",
"has",
"either",
"no",
"effect",
"(",
"RAR",
"beta",
")",
"or",
"an",
"inhibitory",
"activity",
"(",
"RAR",
"gamma",
"and",
"type",
"II",
"TGase",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
9,
10,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
9,
10,
0,
9,
10,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
10,
10,
0,
0
] |
17245 | [
"Similarly",
",",
"an",
"excess",
"of",
"FK506",
"is",
"needed",
"to",
"revert",
"rapamycin-mediated",
"inhibition",
"of",
"IL-2",
"-induced",
"proliferation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0
] |
10486 | [
"The",
"recent",
"discovery",
"of",
"the",
"transcription",
"factor",
"nuclear",
"factor",
"kappa",
"B",
"(",
"NF-kappa",
"B",
")",
"is",
"reviewed",
"and",
"several",
"potential",
"pathways",
"for",
"cytokine",
"-induced",
"periodontal",
"tissue",
"damage",
",",
"mediated",
"by",
"NF-kappa",
"B1",
"are",
"discussed",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0
] |
12002 | [
"Elf-2",
",",
"a",
"rhombotin-2",
"binding",
"ets",
"transcription",
"factor",
":",
"discovery",
"and",
"potential",
"role",
"in",
"T",
"cell",
"leukemia",
"."
] | [
9,
0,
0,
9,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16361 | [
"These",
"changes",
"in",
"the",
"enhancer",
"element",
"were",
"identified",
"in",
"the",
"original",
"AL1",
"virus",
"stock",
"."
] | [
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
13467 | [
"Consistent",
"with",
"defective",
"transport",
"along",
"the",
"endocytic",
"pathway",
",",
"the",
"maturation",
"of",
"SDS-stable",
"class",
"II",
"alphabeta",
"dimers",
"--",
"dependent",
"upon",
"removal",
"of",
"Ii",
"chain",
"and",
"peptide",
"loading",
"of",
"class",
"II",
"dimers",
"in",
"the",
"MHC",
"class",
"II",
"compartment",
"--",
"was",
"markedly",
"impaired",
"in",
"M.",
"tuberculosis",
"-infected",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
9,
10,
10,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
7914 | [
"These",
"effects",
"were",
"specific",
"in",
"that",
"the",
"potentiated",
"phagocytosis",
"of",
"apoptotic",
"neutrophils",
"was",
"completely",
"blocked",
"by",
"the",
"glucocorticoid",
"receptor",
"antagonist",
"RU38486",
",",
"and",
"glucocorticoids",
"did",
"not",
"promote",
"5-day",
"M",
"phi",
"ingestion",
"of",
"opsonized",
"erythrocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
Subsets and Splits
No saved queries yet
Save your SQL queries to embed, download, and access them later. Queries will appear here once saved.