id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
13608
[ "Thus", ",", "Fas", "expression", "is", "likely", "mediated", "by", "PKC", "through", "TDAG51", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 1, 0 ]
9184
[ "The", "maximal", "stimulation", "of", "the", "lymphocytes", ",", "as", "measured", "by", "the", "maximal", "thymidine", "incorporation", "(", "in", "the", "absence", "of", "cortisol", ")", "in", "the", "FMS", "group", "was", "approximately", "1.5", "times", "higher", "(", "p", "<", ".05", ")", "than", "in", "the", "control", "or", "LBP", "group", "." ]
[ 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18447
[ "Dephosphorylation", "by", "in", "vitro", "treatment", "with", "calcineurin", "or", "alkaline", "phosphatase", "restores", "NFATp", "DNA", "binding", "activity", "and", "its", "ability", "to", "reconstitute", "an", "NFAT", "complex", "with", "Fos", "and", "Jun", "proteins", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 9, 0, 0 ]
8383
[ "Surprisingly", ",", "although", "stimulation", "of", "Jurkat", "T", "cells", "with", "either", "CHO-CD80", "or", "anti-CD28", "mAb", "resulted", "in", "robust", "tyrosine", "phosphorylation", "of", "CD28", "itself", ",", "ligation", "with", "CHO-CD86", "was", "unable", "to", "induce", "detectable", "CD28", "tyrosyl", "phosphorylation", "over", "a", "range", "of", "stimulation", "conditions", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1863
[ "Inhibition", "effects", "versus", "time", "were", "described", "by", "a", "pharmacodynamic", "model", "using", "MPL", "concentrations", "in", "plasma", "as", "an", "input", "function", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]
18458
[ "Interestingly", ",", "Oct1", "and", "NF-AT", "DNA", "binding", "activity", "were", "not", "affected", "by", "cysteamine", "treatment", ",", "suggesting", "that", "oxidative", "signalling", "processes", "operate", "in", "a", "selective", "manner", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
13945
[ "Furthermore", ",", "HL-60", "cells", "transduced", "with", "a", "bcl-2", "expression", "vector", "showed", "the", "same", "differentiation", "response", "to", "retinoids", "as", "did", "parental", "HL-60", "cells", "even", "though", "apoptosis", "was", "inhibited", "in", "these", "bcl-2-transduced", "cells", ",", "suggesting", "that", "differentiation", "and", "apoptosis", "are", "regulated", "independently", "in", "myeloid", "leukemic", "cells", "." ]
[ 0, 0, 5, 6, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
6524
[ "AP-1", "but", "not", "NF-IL-6", "DNA", "binding", "activity", "was", "also", "detected", "in", "C5a-stimulated", "PBMC", ";", "however", ",", "its", "delayed", "expression", "(", "maximal", "at", "4", "hours", ")", "suggested", "a", "less", "important", "role", "in", "the", "rapid", "production", "of", "IL-8", "." ]
[ 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
11021
[ "Isolated", "thymic", "T", "cells", "from", "the", "transgenic", "mice", "also", "show", "a", "dramatically", "decreased", "survival", "rate", "when", "evaluated", "in", "culture", "under", "conditions", "that", "do", "not", "favor", "activation", "." ]
[ 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14202
[ "Transcriptional", "activation", "of", "the", "macrophage", "colony-stimulating", "factor", "gene", "by", "IL-2", "is", "associated", "with", "secretion", "of", "bioactive", "macrophage", "colony-stimulating", "factor", "protein", "by", "monocytes", "and", "involves", "activation", "of", "the", "transcription", "factor", "NF-kappa", "B", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 2, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 7, 0, 0, 0, 0, 0, 9, 10, 9, 10, 0 ]
12813
[ "These", "results", "collectively", "reveal", "a", "complex", "interaction", "of", "STAT5", "with", "other", "signaling", "pathways", "and", "illustrate", "that", "regulation", "of", "gene", "expression", "requires", "integration", "of", "opposing", "signals" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1399
[ "Within", "this", "region", "we", "have", "identified", "a", "gene", "coding", "for", "a", "1.3-kb", "transcript", ",", "expressed", "only", "in", "restricted", "subsets", "of", "cells", "within", "the", "lymphoid", "lineage", "and", "expressed", "at", "high", "levels", "in", "leukemic", "cells", "carrying", "a", "t", "(", "14", ";", "14", ")", "(", "q11", ";", "q32", ")", "chromosome", "translocation", "or", "a", "inv", "(", "14", ")", "(", "q11", ";", "q32", ")", "chromosome", "inversion", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5533
[ "Surface", "expression", "of", "CD23", "was", "determined", "by", "FACS", "analysis", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
13511
[ "The", "Epstein-Barr", "virus", "Rta", "protein", "activates", "lytic", "cycle", "genes", "and", "can", "disrupt", "latency", "in", "B", "lymphocytes", "." ]
[ 0, 9, 10, 10, 10, 0, 1, 2, 2, 0, 0, 0, 0, 0, 7, 8, 0 ]
4348
[ "Many", "of", "Pb", "'s", "effects", "on", "the", "immune", "system", "could", "be", "explained", "through", "activation", "of", "the", "transcription", "factor", ",", "NF-kappa", "B", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0 ]
17963
[ "Absorptive", "hypercalciuria", "(", "a", "stone-forming", "condition", ")", "is", "characterized", "by", "gut", "hyperabsorption", "of", "calcium", ",", "hypercalciuria", ",", "and", "reduced", "bone", "density", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18455
[ "Taking", "the", "IL-2", "gene", "as", "a", "candidate", ",", "we", "examined", "the", "effect", "of", "cysteamine", "treatment", "on", "early", "gene", "expression", "during", "lymphocyte", "activation", ",", "and", "on", "the", "activity", "of", "transcription", "factors", "AP-1", ",", "NF-kappa", "B", ",", "NF-AT", "and", "Oct1", ",", "whose", "functions", "are", "required", "for", "expression", "of", "the", "IL-2", "mRNA", "." ]
[ 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 9, 10, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
7340
[ "TNF", "mRNA", "expression", "induced", "by", "LPS", "was", "decreased", "when", "the", "pre-treatment", "of", "PBMC", "with", "IL-10", "was", "performed", "on", "plastic", ",", "whereas", "this", "was", "not", "the", "case", "when", "cells", "were", "pre-cultured", "with", "IL-10", "on", "Teflon", "." ]
[ 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
16469
[ "Comparison", "of", "the", "sequences", "of", "all", "elements", "recognized", "by", "TCF-1", "defines", "a", "consensus", "motif", "A/T", "A/T", "C", "A", "A/G", "A", "G", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 9, 0, 0, 1, 2, 1, 2, 2, 2, 2, 2, 2, 0 ]
4566
[ "In", "addition", ",", "IL-13", "phosphorylated", "insulin", "response", "substrate-1", ",", "IL-4R", "p140", ",", "JAK1", ",", "and", "Tyk2", ",", "but", "not", "JAK3", "kinase", "." ]
[ 0, 0, 0, 9, 0, 9, 10, 10, 0, 9, 10, 0, 9, 0, 0, 9, 0, 0, 0, 9, 10, 0 ]
11596
[ "We", "reported", "here", "that", "the", "E1B", "19K", "mutant", "viruses", "were", "unable", "to", "replicate", "efficiently", "in", "a", "monocyte", "cell", "line", ",", "U937", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 5, 0 ]
16099
[ "Deletion", "of", "all", "the", "Sp", "1-binding", "sites", "from", "the", "enhancer", "reduces", "transcription", "by", "80-90", "%", "in", "HeLa", ",", "as", "well", "as", "in", "BJA-B", "cells", ",", "whereas", "the", "removal", "of", "the", "octamer-binding", "site", "reduces", "transcription", "to", "levels", "below", "detection", "in", "both", "cell", "types", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9482
[ "Cyclosporin", "A", "(", "CsA", ")", "may", "achieve", "its", "immunosuppressive", "effects", "by", "inhibiting", "the", "calcium-", "and", "calmodulin-dependent", "phosphatase", "calcineurin", "which", "is", "required", "for", "activation", "of", "target", "genes", "by", "members", "of", "the", "NFAT", "(", "nuclear", "factor", "of", "activated", "T", "cells", ")", "transcription", "factor", "family", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 9, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0 ]
16549
[ "Thus", ",", "each", "factor", "may", "function", "as", "a", "novel", "negative", "regulator", "of", "transcription", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0 ]
7368
[ "Using", "Northern", "blotting", ",", "RNase", "protection", "assay", ",", "and", "nuclear", "run-on", "analyses", ",", "we", "show", "that", "the", "up-regulation", "of", "ASM", "expression", "is", "regulated", "mainly", "at", "the", "level", "of", "transcription", "and", "that", "new", "protein", "synthesis", "is", "required", "for", "enhanced", "ASM", "activity", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4811
[ "The", "binding", "activity", "of", "transcription", "factor", "AP-1", ",", "which", "consists", "of", "dimers", "of", "Fos", "and", "Jun", "family", "proteins", ",", "was", "also", "studied", "using", "a", "gel", "shift", "assay", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3156
[ "It", "also", "suggests", "a", "novel", "specificity-conferring", "mechanism", "for", "mineralocorticoid", "action", "at", "the", "membrane", "level", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17093
[ "Phorbol", "ester", "or", "specific", "antigen", "recognition", "induced", "HIV", "LTR", "transactivation", ",", "whereas", "stimulation", "with", "tumor", "necrosis", "factor", "or", "antibody", "to", "CD3", "did", "not", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 0, 0, 0 ]
7882
[ "SIT", "is", "a", "disulfide-linked", "homodimeric", "glycoprotein", "that", "is", "expressed", "in", "lymphocytes", "." ]
[ 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 7, 0 ]
4839
[ "We", "identified", "a", "region", "of", "the", "c-myb", "5", "'", "flanking", "sequence", "that", "increased", "c-myb", "expression", "during", "T-cell", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 1, 0, 0, 0, 0, 0 ]
10102
[ "Potential", "cis-acting", "elements", "were", "identified", "in", "the", "promoter", "region", "of", "the", "NGAL", "gene", "by", "computer", "analysis", "and", "include", "binding", "sites", "for", "CTF/CBP", ",", "the", "hematopoietic", "transcription", "factors", "GATA-1", "and", "PU.1", ",", "and", "the", "LPS-inducible", "factor", "NF-kappa", "B", "." ]
[ 0, 1, 2, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 0, 9, 0, 0, 9, 10, 10, 9, 0, 9, 0, 0, 0, 9, 10, 10, 10, 0 ]
13912
[ "In", "this", "review", "we", "describe", "the", "defects", "in", "B-", "and", "T-", "lymphocyte", "development", "in", "mice", "carrying", "targeted", "mutations", "in", "the", "E-protein", "genes", "and", "discuss", "our", "current", "understanding", "of", "the", "role", "of", "these", "proteins", "in", "lymphoid", "development" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5749
[ "In", "addition", ",", "T", "cell", "proliferation", "was", "completely", "resistant", "to", "the", "actions", "of", "the", "immunosuppressant", "cyclosporin", "A", "(", "CsA", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6297
[ "In", "the", "present", "study", ",", "by", "using", "an", "in", "vitro", "model", ",", "we", "examined", "whether", "stimulation", "with", "interleukin-6", "(", "IL-6", ")", ",", "an", "immunoregulatory", ",", "multipotential", "cytokine", ",", "modulates", "the", "expression", "and", "activities", "of", "the", "MSR", "in", "macrophages", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 0 ]
3052
[ "In", "addition", ",", "we", "identify", "a", "major", "PB1", "nuclear", "protein-binding", "complex", "that", "is", "not", "present", "in", "resting", "peripheral", "blood", "T", "cells", "but", "is", "rapidly", "induced", "following", "T-cell", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]
7442
[ "Concanavalin", "A-activated", "cycling", "T", "cell", "blasts", "from", "mice", "that", "are", "transgenic", "for", "the", "dominant", "IkappaB", "molecule", "have", "increased", "sensitivity", "to", "Fas-mediated", "apoptosis", ",", "associated", "with", "a", "down-regulation", "of", "NF-kappaB", "complexes", "in", "the", "nucleus", "." ]
[ 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]
13205
[ "Degenerate", "primers", "corresponding", "to", "the", "TFIIIA", "zinc-finger", "consensus", "amino", "acid", "sequences", "and", "to", "the", "POU-homeodomain", "and", "POU-specific", "domain", "were", "used", "to", "amplify", "genes", "on", "the", "basis", "that", "they", "contained", "similarities", "in", "structural", "motifs", "shared", "within", "these", "families", "of", "transcription", "factors", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
6717
[ "Resistance", "to", "tumor", "necrosis", "factor", "induced", "apoptosis", "in", "vitro", "correlates", "with", "high", "metastatic", "capacity", "of", "cells", "in", "vivo", "." ]
[ 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10161
[ "In", "Jurkat", "T", "cells", ",", "induction", "of", "PIF", "DNA", "binding", "activity", "was", "rapidly", "induced", ",", "required", "de", "novo", "protein", "synthesis", ",", "and", "was", "sustained", "at", "a", "high", "level", "for", "at", "least", "23", "h", "." ]
[ 0, 5, 6, 6, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12352
[ "Immunoprecipitation", "analysis", "revealed", "that", "unde3r", "these", "circumstances", ",", "Calphostin", "C", "inhibited", "the", "production", "of", "IL-1beta", "protein", ",", "whereas", "Staurosporine", "allowed", "protein", "production", ",", "but", "inhibited", "its", "secretion", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11681
[ "V3-BH10", ",", "which", "consists", "of", "42", "amino", "acids", "and", "has", "a", "loop", "structure", ",", "suppressed", "IL-2", "-driven", "proliferation", "of", "all", "IL-2-dependent", "cells", "[", "Kit225", ",", "ED-40515", "(", "+", ")", ",", "KT-3", ",", "7-day", "PHA-blasts", ",", "and", "fresh", "peripheral", "blood", "mononuclear", "cells", "]", "tested", ",", "whereas", "it", "did", "not", "suppress", "the", "cell", "growth", "of", "IL-2-independent", "cell", "lines", "(", "Hut102", ",", "Molt-4", ",", "and", "Jurkat", ")", "." ]
[ 9, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 5, 6, 0, 5, 0, 5, 6, 6, 6, 0, 5, 0, 5, 6, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 5, 0, 5, 0, 0, 5, 0, 0 ]
5515
[ "Pretreatment", "with", "the", "broad", "serine/threonine", "kinase", "inhibitor", "staurosporine", "partly", "blocked", "the", "calyculin", "A", "-induced", "STAT3", "phosphorylation", ",", "whereas", "inhibitors", "of", "serine/threonine", "kinases", ",", "such", "as", "mitogen-activated", "protein", "kinase-1", "extracellular-regulated", "kinase-kinase", ",", "mitogen-activated", "protein", "p38", "kinase", ",", "and", "phosphatidylinositol", "3-kinase", ",", "did", "not", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 10, 10, 10, 0, 0, 9, 10, 0, 0, 0, 0 ]
13972
[ "In", "both", "types", "of", "donors", ",", "the", "effect", "of", "IL-13", "on", "IL-2", "-induced", "IFN-gamma", "production", "was", "in", "marked", "contrast", "to", "the", "strong", "inhibition", "seen", "with", "IL-4", "in", "NK", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 0 ]
2990
[ "C3/5", "cells", "developed", "specific", "proliferation", "and", "cytotoxicity", "when", "challenged", "with", "peptide-pulsed", "lymphoblastic", "cell", "lines", "and", "peripheral", "blood", "lymphocytes", "from", "the", "four", "DR11", "(", "+", ")", "APL", "patients", "." ]
[ 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3917
[ "Deranged", "cellular", "cholesterol", "homeostasis", "has", "been", "widely", "recognized", "in", "the", "initiation", "as", "well", "as", "progression", "of", "various", "types", "of", "cancers", "including", "chronic", "myeloid", "leukaemia", "(", "CML", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10851
[ "Taken", "together", ",", "these", "data", "demonstrate", "the", "existence", "of", "an", "HLA-DQ", "isotype-specific", "trans-acting", "factor", ",", "which", "functions", "independently", "of", "CIITA", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 9, 0 ]
12116
[ "Similar", "results", "have", "been", "obtained", "by", "our", "own", "group", "in", "peripheral", "blood", "mononuclear", "cells", "(", "PBMC", ")", "from", "patients", "with", "secondary", "hyperparathyroidism", "to", "chronic", "renal", "failure", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2836
[ "Treatment", "of", "Jurkat", "cells", "with", "mAb", "J393", "induced", "tyrosine", "phosphorylation", "of", "specific", "protein", "substrates", "that", "underwent", "hyperphosphorylation", "upon", "antigen", "receptor", "costimulation", "." ]
[ 0, 0, 5, 6, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 0 ]
10772
[ "The", "third", "site", "was", "occupied", "in", "quiescent", "cells", "or", "in", "cells", "stimulated", "by", "anti", "CD2", "or", "anti", "CD28", "alone", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0 ]
15689
[ "PMA-induced", "CD4", "down-modulation", "occurred", "normally", "." ]
[ 0, 9, 0, 0, 0, 0 ]
3118
[ "The", "gene", "encoding", "the", "Epstein-Barr", "virus", "(", "EBV", ")", "-specific", "dUTPase", "was", "amplified", "from", "virus", "DNA", "by", "PCR", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 1, 2, 0, 0, 0 ]
7482
[ "Retinoidal", "antagonists", "and", "potential", "agonists", "." ]
[ 0, 0, 0, 0, 0, 0 ]
6388
[ "This", "study", "compared", "the", "effect", "of", "these", "stimuli", "on", "endogenous", "IkappaB", "kinase", "(", "IKK", ")", "signalsome", "activation", "and", "IkappaB", "phosphorylation/proteolysis", "in", "human", "monocytic", "cells", "and", "investigated", "the", "role", "of", "the", "signalsome", "proteins", "IKK-alpha", ",", "IKK-beta", ",", "NF-kappaB-inducing", "kinase", "(", "NIK", ")", ",", "IKK-gamma", "(", "NF-kappaB", "essential", "modulator", ")", ",", "and", "IKK", "complex-associated", "protein", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 9, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 9, 0, 9, 10, 0, 9, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
15758
[ "The", "endothelium", "plays", "a", "critical", "role", "in", "inflammation", "by", "directing", "circulating", "leukocytes", "into", "extravascular", "tissues", "by", "expressing", "adhesive", "molecules", "for", "leukocytes", "[", "e.g.", ",", "endothelial-leukocyte", "adhesion", "molecule", "1", "(", "ELAM-1", ")", "and", "intercellular", "adhesion", "molecule", "1", "(", "ICAM-1", ")", "]", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 9, 10, 0, 7, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0 ]
7364
[ "It", "was", "postulated", "that", "this", "NF-kappaB-regulated", "promoter", "might", "play", "a", "role", "in", "the", "activation", "of", "the", "accessory", "cells", "as", "well", "as", "the", "rate", "of", "replication", "of", "HIV-1", "in", "monocyte-derived", "macrophages", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
825
[ "Transcriptional", "activity", "of", "core", "binding", "factor-alpha", "(", "AML1", ")", "and", "beta", "subunits", "on", "murine", "leukemia", "virus", "enhancer", "cores", "." ]
[ 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 1, 2, 2, 2, 2, 0 ]
12461
[ "In", "addition", ",", "both", "heat", "and", "cadmium", "produced", "an", "increase", "in", "the", "amount", "of", "the", "intermediate", "filament", "protein", "vimentin", ",", "as", "determined", "by", "immunoblot", "and", "immunofluorescence", "assays", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
563
[ "The", "normal", "cell", "cycle", "is", "regulated", "by", "several", "molecules", ",", "such", "as", "the", "tumor-suppressor", "protein", "pRb", ",", "the", "G1", "cyclins", ",", "the", "cyclin-dependent", "kinases", ",", "and", "their", "inhibitors", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
17848
[ "Therefore", ",", "HIV-1-induced", "cell", "fusion", "brings", "together", "factors", "that", "upregulate", "virus", "transcription", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9213
[ "The", "OCA-B", "and", "VP16", "interactions", "with", "the", "Oct-1", "POU", "domain", "are", "sufficiently", "different", "to", "permit", "OCA-B", "and", "VP16", "to", "bind", "the", "Oct-1", "POU", "domain", "simultaneously", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 10, 10, 0, 0 ]
17226
[ "Two", "kappa", "B-like", "motifs", "at", "positions", "-98", "to", "-108", "of", "the", "GM-CSF", "promoter", "were", "also", "recognized", "but", "with", "much", "lower", "affinities", "." ]
[ 0, 1, 2, 2, 0, 1, 2, 2, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2157
[ "Retinoid-like", "receptors", "play", "a", "central", "role", "in", "hormonal", "responses", "by", "forming", "heterodimers", "with", "other", "nuclear", "hormone", "receptors", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 0 ]
5641
[ "Body", "weight", ",", "body", "mass", "index", ",", "body", "fat", ",", "lean", "body", "mass", ",", "blood-glucose", ",", "cholesterol", ",", "HDL-cholesterol", ",", "triglyceride", ",", "beta-lipoproteins", ",", "insulin", ",", "gonadotropin", ",", "estradiol", ",", "testosterone", ",", "SHBG", ",", "T3", ",", "T4", "and", "TSH", "levels", "as", "well", "as", "estradiol", "and", "progesterone", "receptor", "levels", "in", "excised", "tumor", "were", "studied", "in", "40", "patients", "with", "breast", "cancer", "prior", "to", "conservative", "treatment", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9236
[ "High-level", "NF-kappaB", "activation", "also", "appears", "to", "be", "a", "critical", "component", "of", "long-term", "outgrowth", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10162
[ "Interestingly", ",", "PIF", "was", "constitutively", "activated", "in", "human", "T-cell", "leukemia", "virus", "type", "1-transformed", "MT-2", "cells", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 6, 0 ]
13903
[ "AF-10", "was", "involved", "in", "5", "of", "6", "evaluable", "cases", ",", "including", "1", "case", "without", "detectable", "CALM", "or", "MLL", "rearrangement", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0 ]
5809
[ "The", "HIV-mediated", "NF-kappa", "B", "activation", "is", "selectively", "reduced", "by", "AO", "to", "PKC-zeta", "." ]
[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
13058
[ "Finally", ",", "it", "would", "be", "useful", "to", "know", "what", "the", "inhibitory", "effects", "of", "CyA", "are", "on", "tolerance", "and", "negative", "regulatory", "events", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6802
[ "Our", "results", "demonstrated", "that", ":", "(", "i", ")", "PGN", "induced", "phosphorylation", "of", "the", "transcription", "factors", "ATF-1", "and", "CREB", ";", "(", "ii", ")", "ATF-1", "and", "CREB", "bound", "DNA", "as", "a", "dimer", "and", "induced", "transcriptional", "activation", "of", "a", "CRE", "reporter", "plasmid", ",", "which", "was", "inhibited", "by", "dominant", "negative", "CREB", "and", "ATF-1", ";", "(", "iii", ")", "PGN", "induced", "phosphorylation", "of", "c-Jun", ",", "protein", "synthesis", "of", "JunB", "and", "c-Fos", ",", "and", "transcriptional", "activation", "of", "the", "AP-1", "reporter", "plasmid", ",", "which", "was", "inhibited", "by", "dominant", "negative", "c-Fos", ";", "and", "(", "iv", ")", "PGN-induced", "activation", "of", "CREB/ATF", "and", "AP-1", "was", "mediated", "through", "CD14", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 9, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 0 ]
17371
[ "Although", "the", "TCE", "is", "similar", "in", "sequence", "to", "a", "consensus", "NF", "kappa", "B", "site", ",", "several", "criteria", "indicate", "that", "TCF-1", "is", "distinct", "from", "NF", "kappa", "B", "." ]
[ 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 0 ]
17252
[ "This", "differentiation", "is", "accompanied", "by", "an", "augmented", "capacity", "to", "generate", "growth", "factors", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
3170
[ "METHOD", "." ]
[ 0, 0 ]
13665
[ "In", "contrast", ",", "induction", "of", "differentiation", "but", "not", "of", "proliferation", "was", "followed", "by", "a", "25-", "to", "30-fold", "increase", "in", "the", "nuclear", "level", "of", "the", "tumor", "suppressor", "proteins", "p53", "(", "wild", "type", ")", ",", "pRb", ",", "and", "p130/Rb2", "and", "of", "the", "p53-dependent", "cyclin", "kinase", "inhibitor", "p21/Cip1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 9, 10, 10, 10, 9, 0 ]
9396
[ "The", "functions", "of", "basic", "helix-loop-helix", "(", "bHLH", ")", "transcription", "factors", "in", "activating", "differentiation-linked", "gene", "expression", "and", "in", "inducing", "G1", "cell", "cycle", "arrest", "are", "negatively", "regulated", "by", "members", "of", "the", "Id", "family", "of", "HLH", "proteins", "." ]
[ 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0 ]
6458
[ "C/EBP", "beta", "was", "detected", "in", "the", "synovial", "lining", "and", "in", "sublining", "cells", "of", "synovial", "tissue", "from", "patients", "with", "both", "rheumatoid", "and", "osteoarthritis", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]
10826
[ "The", "methodology", "employed", "transient", "transfection", "of", "HEK", "293", "cells", "with", "a", "cDNA", "for", "the", "52-kDa", "form", "of", "G", "(", "S", ")", "alpha", "under", "regulation", "by", "inducible", "metallothionein", "promoters", "." ]
[ 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 1, 2, 2, 0 ]
1795
[ "Murine", "B", "lymphocytes", ",", "adipocytes", ",", "and", "olfactory", "neurons", "contain", "a", "DNA-binding", "protein", "that", "participates", "in", "the", "regulation", "of", "genes", "encoding", "tissue-specific", "components", "of", "signal", "transduction", "." ]
[ 7, 8, 8, 0, 7, 0, 0, 7, 8, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0 ]
9103
[ "We", "examined", "33", "patients", "with", "diabetes", "mellitus", "(", "Type", "I", "and", "Type", "II", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10089
[ "RESULTS", ":", "Neutrophil", "adhesion", "to", "cultured", "corneal", "endothelial", "cells", "increased", "significantly", "on", "exposure", "to", "TNFalpha", "(", "451.4+/-45.4", "cells/mm2", ",", "n", "=", "16", ")", "compared", "to", "control", "(", "156.7+/-27.3", "cells/mm2", ",", "n", "=", "16", ",", "P", "<", "0.01", ")", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16106
[ "In", "extracts", "of", "induced", ",", "Il-2", "secreting", "El4", "cells", "three", "individual", "protein", "factors", "bind", "to", "TCEd", "DNA", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 9, 10, 0, 0, 1, 2, 0 ]
3475
[ "The", "mode", "of", "glucocorticoid", "action", "after", "administration", "of", "such", "megadoses", "is", "inexplicable", "up", "to", "now", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16161
[ "The", "kappa", "B", "sequence", "(", "GGGACTTTCC", ")", "binds", "a", "factor", ",", "NF-kappa", "B", ",", "that", "is", "constitutively", "found", "in", "its", "functional", ",", "DNA", "binding", "form", "only", "in", "B", "lymphocytes", "." ]
[ 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
9859
[ "This", "review", "will", "cover", "the", "molecular", "mechanisms", "that", "are", "utilized", "by", "mammalian", "oncogenic", "viruses", "to", "affect", "the", "activity", "of", "Rel/NF-kappa", "B", "transcription", "factors", "and", "the", "role", "of", "Rel/NF-kappa", "B", "in", "the", "regulation", "of", "viral", "gene", "expression", "and", "replication", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1110
[ "Human", "cDNAs", "encoding", "Kruppel-type", "zinc", "finger", "domains", ",", "designated", "KOX", "1-32", ",", "have", "been", "cloned", "from", "human", "T", "lymphocyte", "cell", "line", "libraries", "." ]
[ 1, 2, 0, 9, 10, 10, 10, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0 ]
1903
[ "The", "P", "sequence", "of", "the", "human", "interleukin-4", "(", "IL-4", ")", "gene", ",", "which", "was", "defined", "as", "a", "responsive", "element", "for", "phorbol", "12-myristate", "13-acetate", "and", "calcium", "ionophore", "(", "A23187", ")", "in", "Jurkat", "T", "cells", ",", "shares", "sequence", "similarity", "with", "the", "NF-kappa", "B", "and", "the", "NF-AT", "binding", "sites", "." ]
[ 0, 1, 2, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0 ]
7423
[ "In", "the", "nucleus", ",", "it", "functions", "as", "a", "dimerization", "cofactor", "of", "HNF1", "and", "increases", "the", "transcriptional", "activity", "of", "HNF1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0 ]
9577
[ "Using", "antibodies", "in", "an", "electrophoretic", "mobility", "supershift", "assay", ",", "one", "of", "these", "complexes", "was", "shown", "to", "contain", "NF-kappa", "B1", "and", "RelA", ",", "and", "to", "bind", "with", "higher", "affinity", "to", "the", "consensus", "kappa", "B", "site", "in", "the", "HIV", "long", "terminal", "repeat", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 2, 2, 0 ]
10958
[ "In", "contrast", ",", "released", "TNF-alpha", "was", "not", "responsible", "for", "the", "homotypic", "aggregation", "of", "Ri-I", ",", "Ci-I", ",", "Sc-I", ",", "and", "Raji", "cells", "induced", "by", "mAb", "L243", ",", "and", "it", "did", "not", "affect", "the", "proliferation", "of", "B", "cells", "investigated", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 5, 0, 5, 0, 0, 5, 6, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]
14807
[ "Thus", ",", "autoreactive", "T-cells", "identify", "a", "novel", "antigen", ",", "p38", "jun-B", ",", "in", "IDDM", "and", "appear", "to", "indicate", "subjects", "at", "risk", "for", "the", "development", "of", "clinical", "disease", "." ]
[ 0, 0, 7, 8, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3064
[ "The", "other", "two", "SR", "patients", "had", "an", "abnormally", "low", "GR", "number", "with", "normal", "binding", "affinity", "that", "was", "not", "limited", "to", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
10304
[ "The", "immunoregulatory", "properties", "of", "prolactin", ",", "a", "pituitary", "peptide", "hormone", ",", "have", "received", "renewed", "attention", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9486
[ "Using", "a", "sensitive", ",", "reverse", "transcription-polymerase", "chain", "reaction", "(", "RT-PCR", ")", "assay", ",", "G0S2", "mRNA", "levels", "were", "assayed", "in", "cultured", "blood", "mononuclear", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0 ]
13382
[ "Insulin", "dose-dependently", "increased", "the", "PI-3", ",", "4", ",", "5-P3", "production", "but", "YM268", "had", "no", "significant", "effect", "on", "the", "insulin-dependent", "and", "-independent", "PI", "3-kinase", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10424
[ "We", "here", "report", "that", "(", "i", ")", "like", "PML-RAR", "alpha", "expression", ",", "PLZF-RAR", "alpha", "expression", "blocks", "terminal", "differentiation", "of", "hematopoietic", "precursor", "cell", "lines", "(", "U937", "and", "HL-60", ")", "in", "response", "to", "different", "stimuli", "(", "vitamin", "D3", ",", "transforming", "growth", "factor", "beta1", ",", "and", "dimethyl", "sulfoxide", ")", ";", "(", "ii", ")", "PML-RAR", "alpha", ",", "but", "not", "PLZF-RAR", "alpha", ",", "increases", "RA", "sensitivity", "of", "hematopoietic", "precursor", "cells", "and", "restores", "RA", "sensitivity", "of", "RA-resistant", "hematopoietic", "cells", ";", "(", "iii", ")", "PML-RAR", "alpha", "and", "PLZF-RAR", "alpha", "have", "similar", "RA", "binding", "affinities", ";", "and", "(", "iv", ")", "PML-RAR", "alpha", "enhances", "the", "RA", "response", "of", "RA", "target", "genes", "(", "those", "for", "RAR", "beta", ",", "RAR", "gamma", ",", "and", "transglutaminase", "type", "II", "[", "TGase", "]", ")", "in", "vivo", ",", "while", "PLZF-RAR", "alpha", "expression", "has", "either", "no", "effect", "(", "RAR", "beta", ")", "or", "an", "inhibitory", "activity", "(", "RAR", "gamma", "and", "type", "II", "TGase", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 10, 0, 0 ]
17245
[ "Similarly", ",", "an", "excess", "of", "FK506", "is", "needed", "to", "revert", "rapamycin-mediated", "inhibition", "of", "IL-2", "-induced", "proliferation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
10486
[ "The", "recent", "discovery", "of", "the", "transcription", "factor", "nuclear", "factor", "kappa", "B", "(", "NF-kappa", "B", ")", "is", "reviewed", "and", "several", "potential", "pathways", "for", "cytokine", "-induced", "periodontal", "tissue", "damage", ",", "mediated", "by", "NF-kappa", "B1", "are", "discussed", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0 ]
12002
[ "Elf-2", ",", "a", "rhombotin-2", "binding", "ets", "transcription", "factor", ":", "discovery", "and", "potential", "role", "in", "T", "cell", "leukemia", "." ]
[ 9, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16361
[ "These", "changes", "in", "the", "enhancer", "element", "were", "identified", "in", "the", "original", "AL1", "virus", "stock", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
13467
[ "Consistent", "with", "defective", "transport", "along", "the", "endocytic", "pathway", ",", "the", "maturation", "of", "SDS-stable", "class", "II", "alphabeta", "dimers", "--", "dependent", "upon", "removal", "of", "Ii", "chain", "and", "peptide", "loading", "of", "class", "II", "dimers", "in", "the", "MHC", "class", "II", "compartment", "--", "was", "markedly", "impaired", "in", "M.", "tuberculosis", "-infected", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
7914
[ "These", "effects", "were", "specific", "in", "that", "the", "potentiated", "phagocytosis", "of", "apoptotic", "neutrophils", "was", "completely", "blocked", "by", "the", "glucocorticoid", "receptor", "antagonist", "RU38486", ",", "and", "glucocorticoids", "did", "not", "promote", "5-day", "M", "phi", "ingestion", "of", "opsonized", "erythrocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]