id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
5939
[ "In", "addition", "to", "Bcl-x", ",", "a", "known", "CD40-regulated", "antiapoptotic", "molecule", ",", "we", "identified", "a", "related", "antiapoptotic", "molecule", ",", "A1/Bfl-1", ",", "as", "a", "CD40-inducible", "gene", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 1, 2, 0 ]
2617
[ "Similar", "to", "Mono", "Mac", "6", "cells", ",", "primary", "blood", "monocytes", ",", "when", "precultured", "with", "a", "low", "dose", "of", "LPS", ",", "also", "become", "tolerant", "and", "produce", "little", "TNF", "after", "LPS", "stimulation", "." ]
[ 0, 0, 5, 6, 6, 6, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]
518
[ "Recently", ",", "the", "defective", "gene", "in", "group", "II", "type", "II", "MHC", "CID", "has", "been", "isolated", "and", "termed", "CIITA", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 1, 0 ]
6090
[ "The", "hematopoietic", "cell-specific", "pattern", "of", "MNDA", "expression", "was", "elucidated", "through", "a", "comprehensive", "analysis", "of", "normal", "and", "neoplastic", "tissues", ",", "and", "the", "results", "provide", "further", "evidence", "of", "the", "coexpression", "of", "B-", "and", "myeloid", "cell", "markers", "in", "neoplastic", "B", "cells", "and", "identify", "a", "normal", "B", "cell", "population", "that", "might", "be", "related", "to", "the", "cell", "of", "origin", "of", "a", "subset", "of", "B", "cell", "neoplasms", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 7, 8, 8, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
18044
[ "Western", "blotting", "yielded", "a", "set", "of", "bands", "ranging", "from", "25", "kD", "to", "55", "kD", ",", "resulting", "from", "extensive", "alternative", "splicing", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11617
[ "There", "was", "not", "any", "DNA", "homology", "between", "the", "breakpoints", "in", "the", "second", "exon", "and", "the", "inserting", "sequences", "(", "starting", "at", "nt", "532", ",", "710", ",", "or", "792", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10729
[ "We", "have", "demonstrated", "that", "the", "murine", "FDC-P1-derived", "cell", "line", "WT-19", "transfected", "with", "the", "human", "GM-CSF", "receptor", "alpha", "and", "beta", "subunits", "(", "GM-CSFRalpha", "and", "beta", ")", "can", "be", "induced", "to", "differentiate", "by", "the", "addition", "of", "human", "GM-CSF", "(", "hGM-CSF", ")", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 6, 6, 5, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0 ]
2577
[ "When", "cotransfected", "with", "the", "HIV", "LTR", "CAT", "into", "CV-1", "cells", ",", "both", "the", "pCD41", "and", "pGD41", "clones", "trans-activated", "the", "HIV", "LTR", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 0, 5, 6, 0, 0, 0, 1, 0, 1, 0, 0, 0, 1, 2, 0 ]
8361
[ "Fas", "ligand", "(", "FasL", ")", "on", "cytotoxic", "lymphocytes", "is", "important", "for", "mediating", "apoptosis", "of", "activated", "lymphocytes", "and", "other", "target", "cells", "." ]
[ 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
13202
[ "In", "order", "to", "understand", "this", "block", "the", "cascade", "of", "molecular", "events", "needs", "to", "be", "characterized", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6878
[ "Enforced", "expression", "of", "Id3", ",", "which", "has", "the", "capacity", "to", "inhibit", "many", "basic", "helix-loop-helix", "(", "bHLH", ")", "transcription", "factors", ",", "in", "human", "CD34", "(", "+", ")", "hematopoietic", "progenitor", "cells", "that", "have", "not", "undergone", "T", "cell", "receptor", "(", "TCR", ")", "gene", "rearrangements", "inhibits", "development", "of", "the", "transduced", "cells", "into", "TCRalpha", "beta", "and", "gamma", "delta", "cells", "in", "a", "fetal", "thymic", "organ", "culture", "(", "FTOC", ")", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 7, 8, 8, 8, 8, 8, 8, 8, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 7, 8, 0, 5, 6, 6, 6, 6, 6, 0, 0, 5, 6, 6, 6, 0, 5, 0, 0 ]
8591
[ "The", "study", "of", "NF-kappaB", "showed", "that", "oxLDLs", "led", "to", "a", "decrease", "of", "activation-induced", "p65/p50", "NF-kappaB", "heterodimer", "binding", "to", "DNA", ",", "whereas", "the", "presence", "of", "the", "constitutive", "nuclear", "form", "of", "p50", "dimer", "was", "unchanged", "." ]
[ 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0 ]
4468
[ "These", "studies", "demonstrate", "that", "CMV", "may", "be", "an", "important", "cofactor", "in", "the", "development", "of", "rejection", "and", "infection", "after", "transplantation", "through", "its", "effects", "on", "IL-6", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
16068
[ "Lymphocyte", "glucocorticoid", "receptor", "binding", "during", "depression", "and", "after", "clinical", "recovery", "." ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
15820
[ "Binding", "of", "erythroid", "and", "non-erythroid", "nuclear", "proteins", "to", "the", "silencer", "of", "the", "human", "epsilon-globin-encoding", "gene", "." ]
[ 0, 0, 9, 10, 10, 10, 10, 0, 0, 1, 0, 0, 1, 2, 2, 0 ]
18228
[ "However", ",", "activation", "from", "a", "remote", "position", "could", "only", "be", "achieved", "with", "the", "C-terminus", "of", "Oct-2a", "in", "B", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 7, 8, 0 ]
13856
[ "Normal", "artery", "specimens", "(", "n", "=", "6", ")", "reveal", "minimal", "immunoreactive", "PPARgamma", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
17521
[ "The", "changes", "in", "the", "mRNA", "levels", "of", "these", "protooncogenes", "in", "Hyon", "cells", "were", "most", "pronounced", "at", "42", "and", "43", "degrees", "C", ";", "kinetic", "analysis", "demonstrated", "that", "the", "changes", "could", "be", "detected", "within", "30", "min", "of", "heat", "shock", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4872
[ "Both", "limiting-component", "transcription", "assays", "and", "DNA", "binding", "assays", "identified", "the", "class", "III", "gene", "transcription", "factor", "TFIIIB", "as", "the", "principle", "target", "of", "Tax", "activity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 9, 0, 0, 0, 0, 0, 9, 0, 0 ]
11369
[ "These", "transcriptional", "regulators", "in", "turn", "trigger", "a", "cascade", "of", "genetic", "changes", "that", "ultimately", "determine", "the", "course", "of", "the", "cells", "during", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11539
[ "There", "was", "a", "significant", "negative", "correlation", "between", "IC50S", "of", "prednisolone", "and", "increase-ratios", "(", "post/pre", "ratio", ")", "of", "Bmax", "after", "mitogen", "stimulation", "(", "p", "<", "0.05", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
13237
[ "In", "contrast", ",", "no", "upregulation", "of", "the", "lipoxygenase", "activity", "was", "observed", "when", "the", "macrophages", "were", "prepared", "from", "homozygous", "STAT6", "-deficient", "mice", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 9, 0, 0, 0 ]
15073
[ "Moreover", ",", "this", "site", "is", "occupied", "by", "BSAP", "in", "vivo", "in", "a", "CD19-expressing", "B-cell", "line", "but", "not", "in", "plasma", "or", "HeLa", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 7, 0, 5, 6, 0 ]
10046
[ "Anti-TNF-alpha", "also", "prevented", "nuclear", "factor-kappa", "B", "(", "NF-kappa", "B", ")", "activation", ",", "and", "a", "good", "correlation", "between", "this", "inhibition", "and", "inhibition", "of", "HIV", "replication", "was", "observed", "." ]
[ 9, 0, 0, 9, 10, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1071
[ "Different", "elements", "thus", "contribute", "to", "IL-2", "promoter", "activity", "in", "different", "cells", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0 ]
4318
[ "NF-IL6", "mRNA", "levels", "were", "not", "affected", "by", "IL-10", "or", "IL-4", ",", "suggesting", "that", "IL-4", "affects", "binding", "activity", "of", "preexisting", "NF-IL6", "." ]
[ 3, 4, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0 ]
10146
[ "No", "RNA-packaging", "defect", "could", "be", "measured", "for", "any", "of", "the", "mutant", "viruses", "as", "determined", "by", "quantification", "of", "their", "HIV", "genomic", "RNA", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0 ]
4534
[ "This", "is", "achieved", "in", "part", "through", "the", "positive", "activities", "of", "the", "AP-1", "and", "Elf-1", "sites", "in", "the", "IL-3", "promoter", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 0 ]
10977
[ "This", "indicated", "that", "the", "EKLF-/-", "erythrocytes", "in", "adult", "animals", "must", "be", "short-lived", ",", "apparently", "due", "to", "the", "imbalance", "of", "beta-", "versus", "alpha-globin", "chains", ",", "leading", "to", "the", "precipitation", "of", "excess", "alpha-globin", "chains", "to", "form", "Heinz", "bodies", "." ]
[ 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
4107
[ "Anergic", "CD4+", "Th", "cells", "do", "not", "produce", "IL-2", "when", "challenged", "with", "Ag-pulsed", "accessory", "cells", "because", "of", "a", "transcriptional", "defect", "." ]
[ 5, 6, 6, 6, 0, 0, 0, 9, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0 ]
2512
[ "All", "cases", "tested", "(", "6/20", ")", ",", "including", "the", "case", "with", "t", "(", "11", ";", "17", ")", ",", "failed", "to", "differentiate", "in", "vitro", "in", "response", "to", "all-trans", "retinoic", "acid", "(", "ATRA", ")", ",", "suggesting", "that", "these", "cases", "may", "account", "for", "some", "APLs", "that", "have", "not", "shown", "a", "clinical", "response", "to", "ATRA", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6751
[ "IL-4", "conducts", "its", "biological", "activities", "through", "binding", "to", "the", "IL-4", "receptor", "(", "IL-4R", ")", "on", "the", "surface", "of", "target", "cells", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 7, 8, 0 ]
2751
[ "No", "correlation", "between", "chromosome", "1", "alterations", "and", "nuclear", "grade", ",", "age", ",", "size", ",", "lymph-node", "involvement", ",", "hormonal", "receptor", "presence", ",", "proliferation", "activity", "or", "p53", "protein", "expression", "was", "detected", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
289
[ "Interleukin", "12", "(", "IL-12", ")", "is", "an", "important", "immunoregulatory", "cytokine", "whose", "receptor", "is", "a", "member", "of", "the", "hematopoietin", "receptor", "superfamily", "." ]
[ 9, 10, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
3537
[ "Here", "we", "report", "that", "sustained", "high", "concentrations", "of", "Ca2+", ",", "but", "not", "transient", "pulses", ",", "are", "required", "to", "maintain", "NF-AT", "transcription", "factors", "in", "the", "nucleus", ",", "where", "they", "participate", "in", "Ca2+-dependent", "induction", "of", "genes", "required", "for", "lymphocyte", "activation", "and", "proliferation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 7, 0, 0, 0, 0 ]
7610
[ "Before", "and", "after", "treatment", ",", "the", "patients", "underwent", "fiberoptic", "bronchoscopy", "with", "endobronchial", "biopsy", "and", "sampling", "of", "venous", "blood", "for", "measurements", "of", "GR", "mRNA", "levels", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0 ]
652
[ "We", "have", "previously", "described", "a", "mutant", "B", "lymphoblastoid", "cell", "line", ",", "Clone-13", ",", "that", "expresses", "HLA-DQ", "in", "the", "absence", "of", "HLA-DR", "and", "-DP", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 5, 6, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0 ]
11234
[ "Tyrosine", "phosphorylation", "of", "Stat3", "and", ",", "to", "a", "lesser", "extent", ",", "Stat1", "was", "also", "detected", "following", "G-CSF", "stimulation", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0 ]
5137
[ "In", "resting", "T", "lymphocytes", ",", "the", "transcription", "factor", "NF-kappaB", "is", "sequestered", "in", "the", "cytoplasm", "via", "interactions", "with", "members", "of", "the", "I", "kappa", "B", "family", "of", "inhibitors", ",", "including", "IkappaBalpha", "and", "IkappaBbeta", "." ]
[ 0, 7, 8, 8, 0, 0, 9, 10, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 9, 0, 9, 0 ]
579
[ "Three", "to", "6", "months", "after", "RAI", ",", "T", "cell", "responses", "to", "TSHR", "peptides", "were", "less", "than", "those", "6-8", "weeks", "after", "RAI", "therapy", ",", "but", "still", "higher", "than", "the", "values", "on", "day", "0", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7566
[ "NF-kappa", "B", "-directed", "luciferase", "activity", "increased", "approximately", "3-fold", "when", "cells", "transfected", "with", "the", "plasmid", "pNF-kappa", "BLUC", "containing", "five", "copies", "of", "consensus", "NF-kappa", "B", "site", "linked", "to", "a", "minimal", "adenovirus", "E1B", "promoter-luciferase", "gene", "were", "exposed", "to", "thrombin", ",", "indicating", "that", "activation", "of", "NF-kappa", "B", "was", "essential", "for", "thrombin", "response", "." ]
[ 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 0, 0 ]
5194
[ "Since", "the", "cells", "were", "not", "treated", "with", "cytokines", "before", "the", "nuclear", "proteins", "were", "extracted", ",", "we", "conclude", "that", "these", "factors", "are", "constitutively", "activated", "in", "vivo", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8296
[ "This", "finding", "supports", "a", "polyclonal", "reactive", "process", "as", "the", "underlying", "etiology", "for", "palmar", "fibromatosis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7378
[ "Endotoxin", "(", "LPS", ")", "signal", "transduction", "in", "human", "monocytes", "leads", "to", "activation", "of", "nuclear", "factor-kappa", "B", "(", "NF-kappaB", ")", "and", "TNF-alpha", "release", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 9, 0, 0 ]
15198
[ "The", "cellular", "oncogene", "c-myb", "can", "interact", "synergistically", "with", "the", "Epstein-Barr", "virus", "BZLF1", "transactivator", "in", "lymphoid", "cells", "." ]
[ 0, 1, 2, 1, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 7, 8, 0 ]
6592
[ "TCR", "affinities", "were", "then", "indirectly", "estimated", "by", "blocking", "CD8", "interaction", "with", "an", "anti-CD8", "mAb", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0 ]
6994
[ "These", "data", "suggest", "that", "USF/c-Myc", "and", "YY1", "may", "play", "an", "important", "role", "in", "the", "HIV-1-replicative", "cycle", ",", "by", "modulating", "both", "the", "viral", "fusion/entry", "process", "and", "viral", "expression", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15579
[ "It", "is", ",", "however", ",", "still", "unclear", "whether", "LTB4", "acts", "in", "this", "regard", "directly", "or", "indirectly", "by", "stimulating", "the", "release", "of", "chemotactic", "and", "inflammatory", "cytokines", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
1084
[ "Glucocorticoid-induced", "apoptosis", "of", "human", "leukemic", "cells", "is", "caused", "by", "the", "repressive", "function", "of", "the", "glucocorticoid", "receptor", "." ]
[ 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
5292
[ "All", "asthmatic", "patients", "showed", "an", "improvement", "in", "their", "FEV1", "values", "after", "corticosteroid", "treatment", "(", "per", "cent", "of", "predicted", "value", "68.28", "+/-", "4.93", "versus", "95.57", "+/-", "6.41", ",", "P", "<", "0.02", ")", ",", "and", "a", "significant", "decrease", "for", "glucocorticoid", "receptor", "mRNA", "expression", "(", "P", "<", "0.02", ")", "was", "observed", "in", "their", "monocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
873
[ "We", "have", "analyzed", "CBF", "beta-MYH11", "fusion", "transcripts", "by", "RT-PCR", "in", "myelomonocytic", "leukemias", ",", "with", "or", "without", "eosinophilia", ",", "to", "determine", "whether", "their", "presence", "correlates", "with", "morphology", "." ]
[ 0, 0, 0, 3, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8049
[ "This", "enzyme", "releases", "arachidonic", "acid", "and", "lyso-phospholipids", "from", "membranes", "which", "are", "metabolized", "to", "eicosanoids", "and", "platelet-activating-factor", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7976
[ "Angiotensin", "II", "activates", "the", "proinflammatory", "transcription", "factor", "nuclear", "factor-kappaB", "in", "human", "monocytes", "." ]
[ 9, 10, 0, 0, 9, 10, 10, 9, 10, 0, 7, 8, 0 ]
6539
[ "In", "chronic", "bronchitis", ",", "few", "cells", "were", "GCRbeta-positive", "and", "their", "numbers", "did", "not", "differ", "significantly", "from", "normal", "control", "subjects", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12974
[ "Highly", "polarized", "HLA", "class", "II", "antigen", "processing", "and", "presentation", "by", "human", "intestinal", "epithelial", "cells", "." ]
[ 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]
17382
[ "High-risk", "patients", "can", "be", "recognized", "morphologically", "." ]
[ 0, 0, 0, 0, 0, 0, 0 ]
10001
[ "This", "reversal", "of", "apoptosis", "almost", "to", "the", "control", "level", "by", "inhibitor", "of", "NF-kappa", "B", "activation", "may", "indicate", "involvement", "of", "this", "signaling", "molecule", "in", "MTBE", "and", "benzene", "induction", "of", "programmed", "cell", "death", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14499
[ "Moreover", ",", "whereas", "both", "Tax", "and", "phorbol", "12-myristate", "13-acetate", "(", "PMA", ")", "are", "able", "to", "efficiently", "induce", "the", "binding", "of", "NF-kappa", "B", "to", "the", "IL-2R", "alpha", "kappa", "B", "site", ",", "PMA", "is", "functionally", "inactive", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0 ]
2311
[ "To", "characterize", "mechanisms", "responsible", "for", "these", "LIF", "effects", ",", "levels", "of", "HIV", "mRNA", ",", "activation", "of", "the", "DNA", "binding", "protein", "nuclear", "factor", "(", "NF", ")", "-kB", ",", "signal", "transduction", "pathways", ",", "and", "potential", "interactions", "with", "other", "cytokines", "were", "analyzed", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 9, 10, 10, 10, 10, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
9212
[ "OCA-B", ",", "however", ",", "interacts", "with", "a", "different", "surface", "of", "the", "DNA-bound", "Oct-1", "POU", "domain", ",", "interacting", "with", "both", "the", "POU", "(", "S", ")", "and", "POU", "(", "H", ")", "domains", "and", "the", "center", "of", "the", "ATGCAAAT", "octamer", "sequence", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
3197
[ "Elf-1", "and", "Stat5", "bind", "to", "a", "critical", "element", "in", "a", "new", "enhancer", "of", "the", "human", "interleukin-2", "receptor", "alpha", "gene", "[", "published", "erratum", "appears", "in", "Mol", "Cell", "Biol", "1997", "Apr", ";", "17", "(", "4", ")", ":", "2351", "]" ]
[ 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2922
[ "Histopathological", "analysis", "revealed", "lymphomas", "of", "T-cell", "type", ",", "often", "comprising", "a", "minor", "B-cell", "component", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7636
[ "IFN-gamma", "production", "is", "strongly", "decreased", "by", "HCSs", "in", "some", "cases", ",", "but", "not", "in", "others", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7737
[ "One", "T-cell", "line", "derived", "from", "ATL", "leukemic", "cells", ",", "TL-Om1", ",", "displayed", "constitutive", "NF-kappaB", "activity", ",", "as", "well", "as", "enhanced", "degradation", "of", "IkappaBalpha", ",", "despite", "the", "lack", "of", "detectable", "Tax", "expression", "." ]
[ 0, 5, 6, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
3499
[ "Peripheral", "blood", "mononuclear", "cell", "GCR", "binding", "affinities", "for", "dexamethasone", "and", "budesonide", "were", "also", "determined", "for", "both", "patient", "groups", "by", "using", "a", "radioligand", "binding", "assay", "and", "Scatchard", "analysis", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8177
[ "The", "thymus", "contained", "small", "numbers", "of", "thymocytes", ",", "and", "TUNEL", "staining", "showed", "that", "higher", "population", "of", "thymocytes", "were", "undergoing", "apoptosis", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0 ]
8511
[ "Oxidants", "are", "also", "known", "to", "activate", "another", "transcription", "factor", ",", "activator", "protein-1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0 ]
1526
[ "SCL", "protein", "levels", "in", "BFU-E-derived", "cells", "were", "highest", "in", "day", "7", "cells", "and", "decreased", "progressively", "from", "day", "7", "to", "day", "14", "of", "culture", ",", "suggesting", "an", "association", "of", "SCL", "with", "erythroid", "proliferation", "." ]
[ 9, 10, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]
18360
[ "Constitutive", "tyrosine", "phosphorylation", "of", "a", "130-kD", "protein", "(", "s", ")", "was", "observed", "in", "the", "tax", "transformed", "fibroblast", "B", "line", "and", "in", "HTLV-1", "transformed", "human", "lymphoid", "lines", ",", "but", "not", "in", "thymocytes", "from", "Thy-tax", "transgenic", "mice", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 5, 6, 6, 6, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]
9616
[ "CD20", "is", "a", "B-lineage-specific", "gene", "expressed", "at", "the", "pre-B-cell", "stage", "of", "B-cell", "development", "that", "disappears", "on", "differentiation", "to", "plasma", "cells", "." ]
[ 9, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
17272
[ "Similar", "constructs", "controlled", "by", "NF-kappa", "B", "or", "the", "entire", "interleukin-2", "enhancer", "show", "bimodal", "expression", "patterns", "during", "induction", ",", "suggesting", "that", "thresholds", "set", "by", "the", "concentration", "of", "transcription", "factors", "may", "be", "a", "common", "property", "of", "inducible", "genes", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
15736
[ "Enhancement", "of", "expression", "of", "TF", "is", "observed", "upon", "adhesion", "of", "Mo", "to", "endothelial", "cells", "and", "extracellular", "matrix", "proteins", ",", "as", "well", "as", "upon", "engagement", "of", "leukocyte", "integrins", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
15201
[ "Here", "we", "demonstrate", "that", "the", "c-myb", "proto-oncogene", "product", ",", "which", "is", "itself", "a", "DNA-binding", "protein", "and", "transcriptional", "transactivator", ",", "can", "interact", "synergistically", "with", "Z", "in", "activating", "the", "BMRF1", "promoter", "in", "Jurkat", "cells", "(", "a", "T-cell", "line", ")", "or", "Raji", "cells", "(", "an", "EBV-positive", "B-cell", ")", ",", "whereas", "the", "c-myb", "gene", "product", "by", "itself", "has", "little", "effect", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 1, 2, 0, 5, 6, 0, 0, 5, 6, 0, 0, 5, 6, 0, 0, 5, 6, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0 ]
6791
[ "Here", ",", "we", "show", "that", "Jagged1", "is", "a", "Rel/NF-kappaB-responsive", "gene", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 1, 2, 0 ]
4580
[ "Therefore", ",", "we", "conclude", "that", "IL-4", "and", "IL-10", "inhibit", "IL-6", "production", "by", "different", "mechanisms", "in", "human", "monocytic", "cell", "lines", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0 ]
2576
[ "Using", "this", "cDNA", "as", "the", "probe", ",", "a", "3.8-kb", "EcoRI", "genomic", "fragment", "encoding", "the", "HHV-6", "(", "GS", ")", "P41", "was", "cloned", "and", "designated", "as", "pGD41", "." ]
[ 0, 0, 1, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 1, 0 ]
5400
[ "A", "subpopulation", "of", "smaller", "cells", "did", "not", "express", "the", "differentiation", "markers", "after", "cadmium", "stimulation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5113
[ "The", "extracts", "were", "compared", "for", "their", "ability", "to", "retard", "the", "migration", "of", "radiolabeled", "double", "stranded", "oligomers", "representative", "of", "the", "VDREs", "of", "the", "human", "osteocalcin", "and", "the", "mouse", "osteopontin", "gene", "promoters", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 0 ]
11581
[ "Pretreatment", "of", "ACH-2", "T", "cells", "by", "NAC", "followed", "by", "stimulation", "with", "PMA", ",", "TNF-alpha", ",", "or", "hydrogen", "peroxide", "(", "H2O2", ")", "resulted", "in", "strong", "suppression", "of", "NF-kappa", "B", "activation", "." ]
[ 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]
1139
[ "The", "effects", "of", "GSSG", "are", "antagonized", "by", "reduced", "thioredoxin", "(", "TRX", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0 ]
16739
[ "These", "are", "prominent", "enzymes", "in", "the", "endocytic", "pathway", "through", "which", "soluble", "protein", "Ag", "enter", "APC", ",", "and", "resistant", "segments", "in", "Ag", "may", ",", "therefore", ",", "be", "expected", "to", "contain", "more", "T-cell", "determinants", "than", "susceptible", "segments", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0 ]
8158
[ "In", "transient", "cotransfection", "experiments", ",", "dominant", "negative", "mutants", "of", "the", "IL-1", "signaling", "pathway", ",", "including", "MyD88", ",", "IRAK", ",", "IRAK2", ",", "and", "TRAF6", "inhibited", "both", "IL-1", "-and", "LPS-induced", "NF-kappaB", "-luciferase", "activity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0, 0, 9, 0, 0, 9, 9, 0, 0 ]
5713
[ "However", ",", "only", "a", "few", "CD8", "(", "+", ")", "-T-cell", "epitopes", "are", "known", ",", "with", "the", "majority", "being", "contained", "in", "the", "pp65", "phosphoprotein", ",", "which", "is", "believed", "to", "dominate", "the", "CD8", "(", "+", ")", "-T-cell", "response", "to", "HCMV", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12199
[ "Time-course", "experiments", "showed", "that", "nuclear", "levels", "of", "GATA-1", "and", "p45", "NF-E2", "proteins", "increased", "during", "BA", "treatment", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]
641
[ "Platelet-activating", "factor", "stimulates", "transcription", "of", "the", "heparin-binding", "epidermal", "growth", "factor-like", "growth", "factor", "in", "monocytes", "." ]
[ 9, 10, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 7, 0 ]
5536
[ "RESULTS", ":", "Nuclear", "factor", "(", "NF", ")", "-kappaB", "is", "the", "main", "transcription", "factor", "involved", "in", "the", "gene", "activation", "that", "follows", "CD23", "cross-linking", "in", "monocytes", "." ]
[ 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 0 ]
15456
[ "Interestingly", ",", "T3", "strongly", "enhanced", "the", "action", "of", "RA", ",", "suggesting", "cooperative", "action", "of", "the", "two", "receptors", "in", "modulating", "erythroid", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11986
[ "The", "gamma", "(", "c", ")", "subunit", "can", "be", "employed", "in", "receptor", "complexes", "for", "IL-2", ",", "-4", ",", "-7", ",", "-9", ",", "and", "-15", ",", "and", "the", "multiple", "signaling", "defects", "that", "would", "result", "from", "a", "defective", "gamma", "(", "c", ")", "chain", "in", "these", "receptors", "are", "proposed", "to", "cause", "the", "severe", "phenotype", "of", "X-SCID", "patients", "." ]
[ 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 9, 10, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14922
[ "We", "tested", "whether", "a", "peptide", "(", "BCR1/25", ")", "encompassing", "the", "fusion", "region", "of", "the", "hybrid", "molecule", "pml/RAR", "alpha", ",", "which", "is", "selectively", "expressed", "by", "acute", "promyelocytic", "leukemia", "(", "APL", ")", "cells", ",", "can", "be", "recognized", "by", "human", "T", "lymphocytes", "in", "vitro", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0 ]
18120
[ "Quantitation", "of", "beta", "1", "triiodothyronine", "receptor", "mRNA", "in", "human", "tissues", "by", "competitive", "reverse", "transcription", "polymerase", "chain", "reaction", "." ]
[ 0, 0, 3, 4, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4438
[ "Thus", ",", "signaling", "in", "NK3.3", "cells", "is", "not", "always", "identical", "with", "that", "in", "primary", "NK", "cells", "." ]
[ 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
1639
[ "The", "interleukin", "2", "receptor", "alpha-chain", "(", "IL-2R", "alpha", ")", "gene", "is", "rapidly", "and", "potently", "induced", "in", "T", "cells", "in", "response", "to", "mitogenic", "stimuli", "." ]
[ 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]
11055
[ "To", "validate", "the", "method", ",", "we", "made", "use", "of", "earlier", "receptor", "binding", "studies", "indicating", "that", "normal", "human", "monocytes", "and", "activated", ",", "but", "not", "resting", ",", "lymphocytes", "expressed", "the", "VDR", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 9, 0 ]
1127
[ "The", "retinoids", "had", "weak", "or", "no", "stimulatory", "effects", "on", "HIV", "production", "by", "T-cell", "lines", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
13008
[ "In", "this", "study", "we", "have", "analyzed", "changes", "in", "gene", "expression", "associated", "with", "this", "variable", "VDR", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
2000
[ "LAM", "and", "LPS", "were", "potent", "inducers", "of", "IL-6", "gene", "expression", "in", "peripheral", "blood", "monocytes", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 7, 8, 8, 0 ]
2497
[ "To", "model", "effective", "versus", "ineffective", "CD3", "-mediated", "stimulation", "in", "peripheral", "T", "cells", ",", "we", "used", "two", "anti-CD3", "mAbs", "that", "differ", "in", "their", "ability", "to", "stimulate", "purified", "T", "cells", ":", "OKT3", ",", "which", "causes", "early", "second", "messenger", "generation", "but", "is", "unable", "to", "activate", "T", "cells", "without", "a", "second", "signal", ",", "and", "64.1", ",", "which", "stimulates", "T", "cell", "proliferation", "on", "its", "own", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]
97
[ "In", "this", "report", "we", "present", "evidence", "that", "the", "cell", "line", "NK3.3", "derived", "from", "human", "NK", "cells", ",", "responds", "to", "both", "IL-2", "and", "IL-12", ",", "as", "measured", "by", "increases", "in", "IFN-gamma", "and", "granulocyte-macrophage", "colony-stimulating", "factor", "(", "GM-CSF", ")", "cytoplasmic", "mRNA", "and", "protein", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 7, 8, 8, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
17559
[ "T", "cell", "activation", "results", "in", "high", "levels", "of", "HIV", "replication", "and", "is", "thought", "to", "be", "one", "mechanism", "leading", "to", "the", "conversion", "from", "latent", "to", "active", "viral", "infection", "." ]
[ 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15996
[ "In", "U-937", "cells", ",", "optimum", "time", "and", "dose", "of", "pretreatment", "with", "1", ",", "25-", "(", "OH", ")", "2D3", "were", "determined", "to", "be", "12-24", "h", "at", "a", "receptor", "saturating", "concentration", "of", "1", ",", "25-", "(", "OH", ")", "2D3", "(", "10", "nM", ")", "." ]
[ 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]