Datasets:

---

siddharthtumre

/

jnlpba-split

like 0

[ "Egr-1", "expression", "correlates", "with", "the", "cellular", "phenotype", "and", "the", "specific", "pattern", "of", "viral", "latency", "established", "within", "the", "individual", "cell", "lines", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]

[ "When", "the", "binding", "of", "ICSAT", "to", "four", "different", "ICSs", "was", "tested", ",", "the", "relative", "differences", "in", "binding", "affinities", "for", "those", "ICSs", "were", "determined", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0 ]

[ "Regulation", "of", "PAK", "activation", "and", "the", "T", "cell", "cytoskeleton", "by", "the", "linker", "protein", "SLP-76", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0 ]

[ "These", "results", "demonstrate", "that", "P-selectin", ",", "through", "its", "ligands", "on", "monocytes", ",", "may", "locally", "regulate", "cytokine", "secretion", "in", "inflamed", "tissues", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]

[ "All", "patients", "showed", "insufficient", "suppression", "of", "serum", "cortisol", "concentrations", "in", "the", "overnight", "1-mg", "dexamethasone", "test", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "HLA-DO", "is", "a", "second", "class", "II-like", "molecule", "that", "physically", "associates", "with", "HLA-DM", "in", "B", "cells", "." ]

[ 9, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 9, 0, 7, 8, 0 ]

[ "Interspecies", "somatic", "cell", "hybrids", "were", "generated", "by", "fusing", "the", "mouse", "T-lymphoma", "cell", "line", ",", "BW5147", ",", "with", "normal", "human", "T", "lymphocytes", "at", "different", "stages", "of", "differentiation", "." ]

[ 0, 5, 6, 6, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 5, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0 ]

[ "An", "NF-kappaB", "/Rel", "binding", "site", "within", "the", "GM-CSF", "promoter", ",", "termed", "the", "kappaB", "element", "appears", "to", "be", "important", "for", "controlling", "expression", "in", "reporter", "gene", "assays", "in", "response", "to", "a", "number", "of", "stimuli", "in", "T", "cells", "." ]

[ 0, 9, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "Surprisingly", ",", "however", ",", "removal", "of", "PC4", "from", "the", "unfractionated", "nuclear", "extract", "has", "no", "detrimental", "effect", "on", "OCA-B", "/", "Oct-1", "-dependent", "transcription", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0 ]

[ "Our", "results", "demonstrate", "that", "PMLRAR", "alpha", "impairs", "neutrophil", "differentiation", "and", "initiates", "the", "development", "of", "APL", "." ]

[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Although", "DEX", "and", "PGE2", "were", "equipotent", "in", "suppressing", "T-cell", "proliferation", ",", "ISO", "was", "much", "less", "effective", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Sustained", "proliferation", "of", "erythroid", "progenitors", "could", "be", "induced", "equally", "well", "from", "purified", "erythroid", "burst-forming", "units", "(", "BFU-E", ")", ",", "from", "CD34", "(", "+", ")", "blast", "cells", ",", "and", "from", "bone", "marrow", "depleted", "from", "CD34", "(", "+", ")", "cells", "." ]

[ 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 5, 0, 0, 0, 7, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0 ]

[ "In", "contrast", "to", "hematopoietic", "cells", ",", "I", "kappa", "B", "alpha-/-", "embryonic", "fibroblasts", "show", "minimal", "constitutive", "NF-kappa", "B", ",", "as", "well", "as", "normal", "signal-dependent", "NF-kappa", "B", "activation", "that", "is", "concomitant", "with", "I", "kappa", "B", "beta", "degradation", "." ]

[ 0, 0, 0, 7, 8, 0, 5, 6, 6, 6, 6, 6, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0 ]

[ "Early", "studies", "in", "murine", "T", "cell", "lines", "indicated", "that", "transcriptional", "transactivation", "functions", "encoded", "in", "the", "glucocorticoid", "receptor", "(", "GR", ")", "N-terminal", "domain", "are", "required", "for", "glucocorticoid-mediated", "apoptosis", "." ]

[ 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0 ]

[ "The", "contribution", "to", "T", "cell-specific", "expression", "by", "other", "promoter", "sites", "was", "assessed", "in", "a", "transient", "expression", "assay", "with", "IL-3", "promoter", "constructs", "linked", "to", "a", "luciferase", "gene", ",", "focusing", "initially", "on", "the", "core", "binding", "factor", "(", "CBF", ")", "site", ",", "which", "is", "footprinted", "in", "vivo", "upon", "T", "cell", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Addition", "of", "phosphorothioate", "oligonucleotides", "that", "contained", "the", "octamer", "consensus", "to", "Jurkat", "T", "leukemia", "cells", "inhibited", "interleukin-2", "(", "IL-2", ")", "secretion", "to", "a", "degree", "similar", "to", "that", "observed", "with", "a", "mutated", "octamer", "site", "in", "the", "IL-2", "enhancer", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 5, 6, 6, 6, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 0 ]

[ "Hydrochlorothiazide", "therapy", "resulted", "in", "life-threatening", "hypokalemia", "." ]

[ 0, 0, 0, 0, 0, 0, 0 ]

[ "Our", "observations", "suggest", "that", "both", "the", "enhancer", "and", "the", "promoter", "have", "a", "complex", "tissue-specific", "structure", "whose", "functional", "interplay", "potentiates", "T-cell-specific", "transcription", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "NFATp", "binds", "to", "two", "sites", "within", "the", "kappa", "3", "element", ",", "and", "occupancy", "of", "both", "sites", "is", "required", "for", "TNF", "alpha", "gene", "induction", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]

[ "Flow", "cytometry", "revealed", "that", "primary", "leukemia", "cells", "from", "a", "patient", "with", "CD8+", "T-PLL", "expressed", "IL-2Ralpha", "and", "beta", "chains", ",", "and", "the", "cells", "showed", "a", "proliferative", "response", "and", "an", "increase", "in", "IL-2Ralpha", "expression", "on", "culture", "with", "exogeneous", "IL-2", "." ]

[ 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0 ]

[ "We", "now", "show", "that", "a", "mutant", "motif", "that", "exchanges", "the", "terminal", "3", "'", "C", "for", "a", "G", "fails", "to", "bind", "the", "p50", "homodimer", "that", "is", "upregulated", "in", "LPS", "toler", "ant", "human", "Mono", "Mac", "6", "cells", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]

[ "On", "the", "other", "hand", ",", "in", "cultures", "of", "2", "beta", "zero-thalassemia", "patients", "without", "high", "HbF", ",", "``", "adult", "''", "pattern", "was", "observed", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Our", "study", "was", "aimed", "at", "investigating", "the", "role", "of", "this", "cell", "population", "in", "progesterone-dependent", "immunomodulation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Therefore", ",", "TNF-alpha", "mRNA", "induction", "by", "PMA", ",", "like", "its", "induction", "by", "virus", "and", "LPS", ",", "is", "not", "primarily", "mediated", "by", "NF-kappa", "B", ",", "but", "rather", "is", "mediated", "through", "other", "sequences", "and", "protein", "factors", "." ]

[ 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "It", "has", "been", "proposed", "that", "their", "expression", "is", "controlled", "by", "the", "non-clonal", ",", "or", "innate", ",", "component", "of", "immunity", "that", "preceded", "in", "evolution", "the", "development", "of", "an", "adaptive", "immune", "system", "in", "vertebrates", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Co-ligation", "of", "the", "A6H", "antigen", "and", "the", "CD3", "complex", "induced", "expression", "of", "the", "transcription", "factor", "AP-1", "in", "CD4+", "T", "cells", ",", "whereas", "no", "increase", "in", "NF-kappa", "B", "and", "octamer-binding", "(", "Oct", ")", "proteins", "was", "seen", "compared", "to", "T", "cells", "stimulated", "with", "anti-CD3", "alone", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 9, 0, 7, 8, 8, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 7, 8, 0, 0, 9, 0, 0 ]

[ "The", "factor", "responsible", "for", "this", "activity", "was", "designated", "Oct", "coactivator", "from", "B", "cells", "(", "OCA-B", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 0, 9, 0, 0 ]

[ "Human", "immunodeficiency", "virus", "type", "2", "(", "HIV-2", ")", ",", "like", "HIV-1", ",", "causes", "AIDS", "and", "is", "associated", "with", "AIDS", "cases", "primarily", "in", "West", "Africa", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "SHP2-interacting", "transmembrane", "adaptor", "protein", "(", "SIT", ")", ",", "a", "novel", "disulfide-linked", "dimer", "regulating", "human", "T", "cell", "activation", "." ]

[ 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]

[ "Interestingly", ",", "coincubation", "of", "35S-TR", "alpha", "1", ",", "GH3", "NE", ",", "and", "unlabeled", "TREp", "resulted", "in", "not", "only", "the", "35S-TR", ":", "TREp", "complex", ",", "but", "in", "two", "additional", "more", "greatly", "retarded", "complexes", "containing", "35S-TR", "alpha", "1", "and", "comigrating", "with", "those", "formed", "by", "GH3", "extract", "alone", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Mutually", "exclusive", "interaction", "of", "a", "novel", "matrix", "attachment", "region", "binding", "protein", "and", "the", "NF-muNR", "enhancer", "repressor", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 9, 10, 10, 0 ]

[ "To", "determine", "whether", "such", "transdominant", "Rev", "proteins", "could", "provide", "long-term", "protection", "against", "HIV", "infection", "without", "affecting", "T", "cell", "function", ",", "T", "leukemia", "cell", "lines", "were", "stably", "transduced", "with", "a", "retroviral", "vector", "encoding", "a", "transdominant", "mutant", "of", "the", "Rev", "protein", ",", "M10", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0 ]

[ "Furthermore", ",", "the", "usefulness", "of", "knock-out", "mice", "for", "the", "generation", "of", "monoclonal", "antibodies", "against", "the", "gene", "product", "of", "interest", "is", "underscored", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "IL-5", "synthesis", "was", "not", "only", "induced", "by", "T-cell", "receptor", "stimulation", "but", "also", "by", "IL-2", "receptor", "stimulation", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]

[ "Thrombin", "stimulation", "of", "the", "T", "leukemic", "cell", "line", "Jurkat", "induced", "a", "transient", "increase", "in", "[", "Ca2+", "]", "i", "." ]

[ 9, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Electrophoretic", "mobility-shift", "assays", "revealed", "that", "recombinant", "IL-2", "increased", "NF-kappaB", "binding", "activity", "in", "nuclear", "extracts", "of", "the", "leukemia", "cells", ",", "and", "Northern", "blot", "analysis", "showed", "that", "IL-2", "increased", "the", "abundance", "of", "mRNAs", "encoding", "the", "NF-kappaB", "components", "c-Rel", "and", "KBF1", "in", "these", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0 ]

[ "In", "this", "study", ",", "therefore", ",", "TNF-alpha", "bioavailability", "from", "mononuclear", "cells", "isolated", "from", "10", "patients", "with", "thalassaemia", "or", "sickle", "cell", "anaemia", "given", "DFX", "as", "compared", "to", "10", "untreated", "subjects", "has", "been", "evaluated", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "CD28", "-associated", "signaling", "pathway", "leading", "to", "cytokine", "gene", "transcription", "and", "T", "cell", "proliferation", "without", "TCR", "engagement", "." ]

[ 0, 9, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "All", "ER+", "and", "ER-", "cells", "tested", "remained", "sensitive", "after", "treatment", "with", "TAM", "to", "lysis", "by", "LAK", "cells", "." ]

[ 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "Overexpression", "of", "UDG", "in", "Saos", "2", "cells", "was", "observed", "to", "delay", "growth", "late", "in", "G1", "phase", "and", "transiently", "arrest", "these", "cells", "from", "progressing", "into", "the", "S", "phase", "." ]

[ 0, 0, 9, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "the", "mouse", "IL-4", "promoter", ",", "there", "are", "five", "elements", "homologous", "to", "the", "human", "P", "sequence", "designated", "conserved", "lymphokine", "element", "0", "(", "CLE0", ")", ",", "P", ",", "P2", ",", "P3", "and", "P4", "." ]

[ 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 2, 0, 1, 0, 0, 1, 0, 1, 0, 1, 0, 1, 0 ]

[ "Recent", "evidence", "has", "implicated", "components", "of", "the", "immune", "system", "in", "the", "pathogenesis", "of", "endometriosis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Phosphorylation", "of", "the", "IkappaB", "cytoplasmic", "inhibitors", ",", "IkappaBalpha", ",", "IkappaBbeta", ",", "and", "IkappaBepsilon", ",", "by", "these", "kinases", "triggers", "proteolytic", "degradation", "and", "the", "release", "of", "NF-kappaB/Rel", "proteins", "into", "the", "nucleus", "." ]

[ 0, 0, 0, 9, 10, 10, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]

[ "However", ",", "most", "attention", "has", "been", "focused", "on", "lipopolysaccharide", "(", "LPS", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Analysis", "of", "whole-cell", "lysates", "by", "antiphosphotyrosine", "immunoblotting", "showed", "that", "incubation", "with", "gamma", "interferon", "brought", "about", "specific", "increases", "in", "phosphotyrosine", "labeling", "of", "several", "proteins", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "this", "study", ",", "we", "examined", "whether", "gp41", "-induced", "IL-10", "up-regulation", "is", "mediated", "by", "the", "previously", "described", "synergistic", "activation", "of", "cAMP", "and", "NF-kappaB", "pathways", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "A", "2-4-fold", "increase", "in", "IFN-beta", "promoter", "transcription", "was", "observed", "in", "Sendai", "virus", "induced", "extracts", ",", "and", "deletion", "of", "PRDI", "and", "PRDII", "elements", "decreased", "this", "induced", "level", "of", "transcription", "." ]

[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0 ]

[ "Two", "regions", ",", "DP1", "(", "-140", "to", "-92", "bp", ")", "and", "DP2", "(", "-353", "to", "-304", "bp", ")", "of", "the", "promoter", "were", "essential", "for", "transcription", "in", "HeLa", "cells", "and", "human", "peripheral", "monocytes", "." ]

[ 0, 0, 0, 1, 0, 1, 2, 2, 2, 0, 0, 1, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 7, 8, 8, 0 ]

[ "Furthermore", ",", "the", "substitution", "of", "this", "GATA", "binding", "site", "by", "a", "canonical", "TFIID", "binding", "site", "suppresses", "the", "promoter", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0 ]

[ "We", "therefore", "tested", "the", "possibility", "that", "the", "GM-CSF", "gene", "is", "also", "regulated", "by", "a", "cognate", "motif", "for", "the", "NF-kappa", "B", "transcription", "factor", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "A", "frameshift", "mutation", "in", "the", "3'-end", "of", "the", "XPB", "gene", "is", "responsible", "for", "a", "concurrence", "of", "two", "disorders", ":", "xeroderma", "pigmentosum", "(", "XP", ")", "and", "Cockayne", "'s", "syndrome", "(", "CS", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "While", "a", "nuclear", "factor", "(", "s", ")", "from", "both", "peripheral", "blood", "monocytes", "and", "T", "cells", "binds", "the", "peri-kappa", "B", "site", ",", "electrophoretic", "mobility", "shift", "assays", "suggest", "that", "either", "a", "different", "protein", "binds", "to", "this", "site", "in", "monocytes", "versus", "T", "cells", "or", "that", "the", "protein", "recognizing", "this", "enhancer", "element", "undergoes", "differential", "modification", "in", "monocytes", "and", "T", "cells", ",", "thus", "supporting", "the", "transfection", "data", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 7, 8, 8, 0, 7, 8, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 8, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 7, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]

[ "Our", "results", "indicate", "that", "the", "stoichiometry", "of", "directly", "interacting", "but", "opposing", "transcription", "factors", "may", "be", "a", "crucial", "determinant", "governing", "processes", "of", "normal", "differentiation", "and", "malignant", "transformation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Lastly", ",", "the", "different", "mobilities", "of", "osteoblast", "nuclear", "extract-DNA", "complexes", "compared", "with", "T-cell", "nuclear", "extract-DNA", "complexes", ",", "along", "with", "the", "inability", "of", "OSF2", "to", "be", "upregulated", "by", "retinoic", "acid", ",", "unlike", "the", "other", "PEBP2", "alpha", "factors", ",", "suggest", "that", "OSF2", "is", "a", "new", "member", "of", "this", "family", "of", "transcription", "factors", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "In", "order", "to", "characterize", "the", "function", "of", "cis-acting", "elements", ",", "we", "have", "developed", "an", "in", "vitro", "system", "in", "which", "a", "DRA", "promoter", "construct", "is", "transcribed", "more", "efficiently", "in", "extracts", "from", "B", "cells", "than", "in", "extracts", "from", "class", "II-negative", "HeLa", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 5, 6, 6, 6, 0 ]

[ "When", "expressed", "in", "COS", "cells", ",", "however", ",", "NFAT1", "is", "capable", "of", "transactivation", ",", "but", "it", "is", "not", "regulated", "correctly", ":", "its", "subcellular", "localization", "and", "transcriptional", "function", "are", "not", "affected", "by", "stimulation", "of", "the", "COS", "cells", "with", "ionomycin", "and", "phorbol", "12-myristate", "13-acetate", "." ]

[ 0, 0, 0, 5, 6, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0 ]

[ "Nevertheless", ",", "the", "molecular", "mechanisms", "involved", "in", "BA-induced", "differentiation", "remain", "largely", "unknown", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Chronic", "human", "immunodeficiency", "virus", "type", "1", "infection", "of", "myeloid", "cells", "disrupts", "the", "autoregulatory", "control", "of", "the", "NF-kappaB/Rel", "pathway", "via", "enhanced", "IkappaBalpha", "degradation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0 ]

[ "Peripheral", "blood", "lymphocytes", "from", "9/19", "SS", "patients", "were", "found", "to", "be", "defective", "in", "their", "ability", "to", "bind", "an", "october", "sequence", "(", "Oct-1", ")", "." ]

[ 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0 ]

[ "The", "increase", "in", "LT-293", "CAT", "activity", "mirrored", "the", "increase", "in", "LT", "biologic", "activity", "seen", "under", "these", "conditions", "." ]

[ 0, 0, 0, 1, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "sequence", "shows", "high", "homology", "with", "the", "murine", "FOSB", "gene", ",", "which", "encodes", "a", "component", "of", "the", "AP1", "transcriptional", "regulator", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "Our", "data", "indicate", "that", "the", "role", "of", "rpoS", "in", "L.", "pneumophila", "is", "very", "different", "from", "what", "has", "previously", "been", "reported", "for", "E.", "coli", "rpoS", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0 ]

[ "Thus", ",", "the", "requirement", "for", "CD28", "in", "IL-2", "promoter", "activation", "appears", "to", "be", "due", "to", "RE/AP", "and", "not", "the", "NFAT", "or", "AP-1", "sites", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "The", "involvement", "of", "NFATp", "in", "transcriptional", "activation", "of", "both", "the", "interleukin-2", "and", "TNF", "alpha", "genes", "suggests", "that", "this", "factor", "plays", "an", "important", "role", "in", "the", "coordinate", "induction", "of", "multiple", "cytokine", "genes", ",", "starting", "at", "the", "earliest", "stages", "of", "T", "cell", "activation", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "proteins", "are", "differentially", "expressed", "in", "human", "glioblastoma", "and", "neuroblastoma", "cell", "lines", "." ]

[ 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0 ]

[ "It", "is", "concluded", "that", "topoisomerase", "II", "inhibitors", "may", "induce", "the", "differentiation", "of", "promonocytic", "cells", ",", "independently", "of", "their", "capacity", "to", "cause", "DNA", "strand", "breaks", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "immediate-early", "gene", "product", "Egr-1", "regulates", "the", "human", "interleukin-2", "receptor", "beta-chain", "promoter", "through", "noncanonical", "Egr", "and", "Sp1", "binding", "sites", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 1, 2, 2, 2, 2, 0, 1, 2, 2, 2, 2, 2, 0 ]

[ "A", "novel", "transcription", "factor", "regulates", "expression", "of", "the", "vacuolar", "H+-ATPase", "B2", "subunit", "through", "AP-2", "sites", "during", "monocytic", "differentiation", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 10, 10, 0, 1, 2, 0, 0, 0, 0 ]

[ "Transcription", "factor", "effects", "on", "chromosome", "constitution", "of", "cell", "hybrids", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 5, 6, 0 ]

[ "Whereas", "the", "previously", "described", "isoform", "NF-ATc/A", "contains", "a", "relatively", "short", "C", "terminus", ",", "the", "longer", "isoforms", ",", "B", "and", "C", ",", "span", "extra", "C-terminal", "peptides", "of", "128", "and", "246", "aa", ",", "respectively", "." ]

[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Role", "of", "GATA-1", "in", "proliferation", "and", "differentiation", "of", "definitive", "erythroid", "and", "megakaryocytic", "cells", "in", "vivo", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0 ]

[ "Furthermore", ",", "NF90", "was", "phosphorylated", "in", "a", "double-stranded", "RNA", "-dependent", "manner", "likely", "by", "the", "interferon-induced", ",", "double-stranded", "RNA-dependent", "protein", "kinase", ",", "PKR", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0 ]

[ "We", "find", "that", "in", "the", "absence", "of", "EKLF", ",", "while", "human", "beta-globin", "expression", "is", "dramatically", "reduced", ",", "gamma-globin", "transcripts", "are", "elevated", "approximately", "5-fold", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0 ]

[ "These", "findings", "suggest", "that", "a", "novel", "AP-2-like", "transcription", "factor", "is", "responsible", "for", "V-ATPase", "B", "subunit", "amplification", "during", "monocyte", "differentiation", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0 ]

[ "An", "interferon-gamma", "activation", "sequence", "mediates", "the", "transcriptional", "regulation", "of", "the", "IgG", "Fc", "receptor", "type", "IC", "gene", "by", "interferon-gamma", "." ]

[ 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 9, 0 ]

[ "By", "contrast", ",", "many", "studies", "have", "reported", "that", "mitogen", "activation", "of", "T", "cells", "increases", "cAMP", "levels", ",", "implying", "a", "positive", "physiological", "role", "for", "cAMP", "in", "the", "activation", "process", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "keeping", "with", "this", "finding", ",", "we", "showed", "that", "apoptosis", "of", "U937", "cells", "is", "characterized", "by", "the", "rapid", "disappearance", "of", "the", "105", ",", "000-", "to", "110", ",", "000-molecular-weight", "pRB", "forms", "concomitantly", "with", "the", "appearance", "of", "a", "smear", "of", "immunoreactive", "products", "with", "a", "molecular", "weight", "of", "greater", "than", "250", ",", "000", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "clinical", "course", "and", "the", "laboratory", "data", "suggest", "that", "the", "tachycardia", "crises", "are", "the", "consequence", "of", "a", "hypersensitivity", "of", "the", "heart", "to", "thyroid", "hormones", ",", "associated", "with", "an", "increased", "number", "of", "T3", "nuclear", "receptor", "sites", "in", "lymphocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 7, 0 ]

[ "Prevalence", "of", "aneuploidy", ",", "overexpressed", "ER", ",", "and", "overexpressed", "EGFR", "in", "random", "breast", "aspirates", "of", "women", "at", "high", "and", "low", "risk", "for", "breast", "cancer", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Positive", "and", "negative", "regulation", "of", "IL-2", "gene", "expression", ":", "role", "of", "multiple", "regulatory", "sites", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Most", "New", "World", "primate", "(", "NWP", ")", "genera", "evolved", "to", "require", "high", "circulating", "levels", "of", "steroid", "hormones", "and", "vitamin", "D", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Endotoxin", "selectively", "induces", "monocyte", "Mn", "superoxide", "dismutase", "(", "SOD", ")", "without", "affecting", "levels", "of", "Cu", ",", "Zn", "SOD", ",", "catalase", ",", "or", "glutathione", "peroxidase", "." ]

[ 9, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 9, 10, 0 ]

[ "The", "results", "were", "compared", "with", "those", "of", "12", "menopausal", "women", "without", "diabetes", "and", "12", "normal", "women", "of", "childbearing", "age", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "observations", "indicate", "that", "the", "monovalent", "gold", "compound", "AuTG", "is", "a", "potentially", "useful", "drug", "for", "the", "treatment", "of", "patients", "infected", "with", "HIV", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Additionally", ",", "it", "inhibited", "the", "production", "of", "LTB4", "(", "IC50", "=", "0.5", "microM", ")", "and", "the", "cytokines", "IL-2", ",", "IL-6", "and", "TNF", "alpha", "(", "IC50", "=", "10-12", "microM", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 9, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "HIV-TF1-binding", "site", "in", "HIV", "LTR", "was", "similar", "to", "the", "site", "recognized", "by", "upstream", "stimulatory", "factor", "(", "USF", ")", "in", "the", "adenovirus", "major", "late", "promoter", "." ]

[ 0, 1, 2, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "In", "contrast", ",", "IL-4", "induces", "different", "C", "epsilon", "GAS", "DNA-protein", "binding", "complexes", "in", "both", "T", "and", "NK", "cells", "." ]

[ 0, 0, 0, 9, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 7, 8, 0 ]

[ "Here", "we", "show", "that", "the", "I", "alpha1", "promoter", "contains", "several", "binding", "sites", "for", "the", "AML/PEBP2/CBF", "family", "of", "transcription", "factors", "and", "that", "AML", "and", "Ets", "proteins", "are", "major", "regulators", "of", "the", "basal", "and", "TGF-beta-inducible", "promoter", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "BASH", "becomes", "tyrosine-phosphorylated", "with", "the", "B", "cell", "Ag", "receptor", "(", "BCR", ")", "cross-link", "or", "by", "coexpression", "with", "Syk", "and", "Lyn", "and", "associates", "with", "signaling", "molecules", "including", "Syk", "and", "a", "putative", "chicken", "Shc", "homologue", "." ]

[ 9, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 10, 0, 9, 0, 0, 9, 10, 10, 10, 0 ]

[ "It", "was", "shown", "by", "transient", "expression", "assay", "that", "HS-40", "behaved", "as", "an", "authentic", "enhancer", "for", "high-level", "zeta", "2", "globin", "promoter", "activity", "in", "K562", "cells", ",", "an", "erythroid", "cell", "line", "of", "embryonic", "and/or", "fetal", "origin", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 0, 0, 1, 2, 2, 2, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "PPARgamma", "is", "likely", "to", "be", "an", "important", "regulator", "of", "monocyte/macrophage", "function", "with", "relevance", "for", "human", "atherosclerotic", "disease", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Both", "U", "alpha", "A", "and", "alpha", "B5A", "also", "failed", "to", "respond", "to", "another", "modulating", "agent", ",", "1", "alpha", ",", "25-dihydroxycholecalciferol", "(", "DHCC", ")", ",", "but", "only", "U", "alpha", "S", "and", "not", "alpha", "G2S", "showed", "an", "enhanced", "response", "to", "DHCC", "." ]

[ 0, 5, 6, 6, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]

[ "Correspondingly", ",", "RNase", "treatment", "had", "no", "effect", "on", "hybridization", "pattern", "at", "all", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Bcl-6", "expression", "in", "reactive", "follicular", "hyperplasia", ",", "follicular", "lymphoma", ",", "and", "angioimmunoblastic", "T-cell", "lymphoma", "with", "hyperplastic", "germinal", "centers", ":", "heterogeneity", "of", "intrafollicular", "T-cells", "and", "their", "altered", "distribution", "in", "the", "pathogenesis", "of", "angioimmunoblastic", "T-cell", "lymphoma", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "When", "18C7", "was", "incubated", "with", "liganded", "MR", ",", "it", "was", "able", "to", "partly", "displace", "(", "20", "%", ")", "the", "hormone", "from", "its", "binding", "site", "." ]

[ 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "responses", "of", "PBMC", "from", "Graves", "'", "patients", "before", "RAI", "therapy", "were", "less", "than", "those", "in", "the", "presurgical", "group", "." ]

[ 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Intestinal", "epithelial", "cells", "can", "express", "HLA", "class", "II", "antigens", "and", "may", "function", "as", "antigen-presenting", "cells", "to", "CD4", "(", "+", ")", "T", "cells", "within", "the", "intestinal", "mucosa", "." ]

[ 7, 8, 8, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0 ]

[ "RESULTS", ":", "A", "human", "IL-5", "promoter/enhancer-luciferase", "gene", "construct", ",", "pIL-5", "(", "-511", ")", "Luc", ",", "was", "transcribed", "on", "activation", "of", "IL-5-producing", "T-cell", "clones", ",", "but", "not", "IL-5-nonproducing", "clones", "." ]

[ 0, 0, 0, 0, 1, 2, 2, 2, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 5, 6, 0 ]

[ "Sterol", "dependent", "LDL-receptor", "gene", "transcription", "in", "lymphocytes", "from", "normal", "and", "CML", "patients", "." ]

[ 0, 0, 1, 2, 0, 0, 7, 0, 0, 0, 0, 0, 0 ]

[ "Receptor", "number", "on", "the", "control", "day", "did", "not", "correlate", "significantly", "with", "the", "degree", "of", "receptor", "down-regulation", ",", "severity", "of", "depression", "or", "cortisol", "concentrations", "across", "all", "the", "subjects", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]