Datasets:

---

siddharthtumre

/

jnlpba-split

like 0

[ "We", "have", "applied", "flow", "cytometry", "to", "the", "investigation", "of", "interferon-gamma", "activation", "of", "human", "monocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0 ]

[ "The", "C/EBP", "motif", "is", "bound", "by", "Ig/EBP-1", "in", "pre-B", "cell", "and", "T", "cell", "extracts", ",", "but", "is", "replaced", "by", "nuclear", "factor-IL-6beta", "or", "a", "nuclear", "factor-IL-6beta-Ig/EBP-1", "heterodimer", "in", "plasmacytoma", "cell", "extracts", "." ]

[ 0, 1, 2, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0 ]

[ "These", "data", "suggest", "that", "the", "paternal", "X", "chromosome", "carries", "the", "de", "novo", "alpha-galactosidase", "A", "mutation", "and", "that", "uneven", "X", "inactivation", "is", "the", "underlying", "mechanism", "for", "disease", "expression", "in", "this", "novel", "female", "MZ", "twin", "pair", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "arrangement", "of", "Ets", "sites", ",", "coupled", "with", "the", "tissue-", "and", "developmental-specific", "expression", "of", "Ets", "members", ",", "likely", "play", "a", "key", "role", "in", "defining", "the", "pattern", "of", "alpha", "4", "integrin", "." ]

[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "The", "mechanism", "by", "which", "estrogen", "exerts", "its", "anti-inflammatory", "effect", "is", "not", "yet", "understood", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "show", "here", "that", "chronic", "HIV", "infection", "results", "in", "both", "induction", "of", "a", "nuclear", "factor", "with", "antigenic", "properties", "indistinguishable", "from", "those", "of", "NF-kappa", "B", "and", "permanently", "increased", "HIV", "enhancer", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 1, 2, 0, 0 ]

[ "We", "propose", "that", "HePTP", "plays", "a", "negative", "role", "in", "antigen", "receptor", "signaling", "by", "specifically", "regulating", "MAP", "kinases", "in", "the", "cytosol", "and", "at", "early", "time", "points", "of", "T", "cell", "activation", "before", "the", "activation-induced", "expression", "of", "nuclear", "dual-specific", "MAP", "kinase", "phosphatases", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0 ]

[ "Excess", "beta-catenin", "can", "squelch", "reporter", "gene", "activation", "by", "LEF-1-beta-catenin", "complexes", "but", "not", "activation", "by", "the", "transcription", "factor", "VP16", "." ]

[ 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 9, 0 ]

[ "The", "last", "13", "amino", "acids", "containing", "a", "PXQXT/S", "sequence", "are", "highly", "conserved", "in", "human", "and", "simian", "EBV", "LMP1", "but", "do", "not", "bind", "TRAF3", ",", "suggesting", "a", "distinct", "role", "for", "this", "conserved", "region", "of", "LMP1", "." ]

[ 0, 9, 10, 10, 10, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "Further", "characterization", "of", "these", "cells", "should", "identify", "factors", "involved", "in", "the", "growth", ",", "terminal", "differentiation", "and", "activation", "of", "osteoclasts", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]

[ "Our", "study", "in", "differentiated", "cells", "provides", "a", "visual", "demonstration", "that", "physical", "separation", "from", "XIC/XIST", "does", "not", "result", "in", "reactivation", "of", "inactive", "X-chromosome", "material", "and", "that", "X", "inactivation", "is", "not", "spread", "to", "the", "translocated", "autosomes", "irrespective", "of", "the", "position", "of", "XIC/XIST", "." ]

[ 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 0 ]

[ "The", "binding", "of", "3H-PGG-Glucan", "to", "human", "leukocyte", "membranes", "was", "specific", ",", "concentration-dependent", ",", "saturable", ",", "and", "high", "affinity", "(", "Kd", "approximately", "6", "nM", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Homodimerization", "of", "the", "human", "interleukin", "4", "receptor", "alpha", "chain", "induces", "Cepsilon", "germline", "transcripts", "in", "B", "cells", "in", "the", "absence", "of", "the", "interleukin", "2", "receptor", "gamma", "chain", "." ]

[ 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 3, 4, 4, 0, 7, 8, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0 ]

[ "The", "malignant", "cells", "of", "acute", "promyelocytic", "leukemia", "(", "APL", ")", "contain", "a", "reciprocal", "chromosomal", "translocation", "that", "fuses", "the", "promyelocytic", "leukemia", "gene", "(", "PML", ")", "with", "the", "retinoic", "acid", "receptor", "alpha", "gene", "(", "RAR", "alpha", ")", "." ]

[ 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 9, 10, 0, 0 ]

[ "The", "protein", "is", "the", "murine", "homologue", "to", "the", "recently", "described", "human", "coactivator", "Bob1", "(", "hBob1", ")", ",", "also", "referred", "to", "as", "OBF-1", "or", "OCA-B", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]

[ "We", "propose", "that", "Jun", "plays", "a", "bifunctional", "role", "on", "GR", "-dependent", "transcriptional", "activation", "of", "GRE", ",", "selecting", "either", "synergistic", "or", "antagonistic", "activity", "depending", "on", "the", "cell-specific", "microenvironment", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "B", "series", "cells", "resembled", "the", "A", "series", "cells", "in", "exhibiting", "faster", "growth", "rates", "than", "the", "parental", "HL60", "cells", "and", "showed", "high", "levels", "of", "vitamin", "D", "receptor", "and", "retinoid", "receptor", "X", "proteins", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 10, 10, 10, 0 ]

[ "Tolerance", "to", "lipopolysaccharide", "involves", "mobilization", "of", "nuclear", "factor", "kappa", "B", "with", "predominance", "of", "p50", "homodimers", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 9, 0, 0 ]

[ "The", "specificity", "of", "DNA", "binding", "by", "cell-free", "synthesized", "hGR", "was", "analyzed", "further", "by", "examining", "the", "abilities", "of", "various", "DNAs", "to", "compete", "for", "binding", "to", "a", "naturally", "occurring", "GRE", "found", "in", "the", "mouse", "mammary", "tumor", "virus-long", "terminal", "repeat", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0 ]

[ "Thyroid", "hormone", "(", "T3", ")", "alone", "caused", "similar", "but", "weaker", "effects", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "findings", "have", "suggested", "that", "JAK3", "represents", "a", "pharmacological", "target", "to", "control", "certain", "lymphoid-derived", "diseases", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "CD15", "cross-linking", "also", "concomitantly", "increased", "interleukin-1", "beta", "(", "IL-1", "beta", ")", "mRNA", ",", "while", "no", "apparent", "change", "was", "observed", "in", "the", "levels", "of", "beta-actin", "mRNA", ",", "indicating", "specificity", "." ]

[ 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0 ]

[ "We", "investigated", "how", "these", "stimuli", "affect", "mitogen", "activated", "protein", "(", "MAP", ")", "kinases", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0 ]

[ "When", "this", "domain", "was", "transferred", "to", "a", "potent", "activator", ",", "transcription", "was", "strongly", "inhibited", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", "regulates", "cytokine", "gene", "expression", "in", "T", "cells", "through", "cis-acting", "elements", "located", "in", "the", "promoters", "of", "several", "cytokine", "genes", "." ]

[ 0, 9, 10, 10, 10, 10, 10, 0, 9, 0, 0, 1, 2, 0, 0, 7, 8, 0, 1, 2, 0, 0, 0, 1, 0, 0, 1, 2, 0 ]

[ "The", "expression", "of", "c-fos", ",", "c-jun", "and", "jun", "B", "proto-oncogenes", "was", "studied", "in", "phytohemagglutinin", "(", "PHA", ")", "activated", "peripheral", "blood", "lymphocytes", "(", "PBL", ")", "from", "young", "and", "aged", "humans", "." ]

[ 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 6, 0, 7, 0, 0, 0, 0, 0, 0, 0 ]

[ "Fine", "mutagenesis", "dissected", "these", "activities", "to", "different", "regions", "of", "the", "5'-UTR", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0 ]

[ "Regulation", "of", "immunoglobulin", "heavy", "chain", "(", "IgH", ")", "gene", "expression", "is", "controlled", "by", "a", "B", "cell-specific", "promoter", ",", "intronic", "enhancer", "and", "additional", "B", "cell-specific", "enhancer", "elements", "identified", "recently", "in", "the", "3", "'", "end", "of", "the", "IgH", "locus", "." ]

[ 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 2, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "Pathogenesis", "of", "atherosclerosis", "." ]

[ 0, 0, 0, 0 ]

[ "By", "double-immunogold", "labeling", "of", "PML", "and", "LYSP100", ",", "some", "LANDs", "were", "shown", "to", "contain", "both", "PML", "and", "LYSP100", "." ]

[ 0, 0, 0, 0, 7, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 1, 0 ]

[ "This", "includes", "a", "very", "low", "apparent", "dissociation", "constant", "(", "Kd", ")", "of", "0.1", "nM", "for", "both", "aldosterone", "and", "the", "effect", "on", "the", "Na", "(", "+", ")", "-H", "(", "+", ")", "-antiport", ",", "a", "high", "turnover", "rate", ",", "and", "the", "almost", "exclusive", "binding", "selectivity", "for", "aldosterone", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "significant", "difference", "was", "noted", "in", "the", "prevalence", "of", "one", "or", "more", "abnormal", "biomarkers", "between", "the", "high", "risk", "and", "low", "risk", "women", "(", "p", "<", "0.001", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "results", "suggest", "that", "UV-induced", "signal", "transduction", "is", "mediated", "via", "cell", "surface", "receptors", "that", "normally", "respond", "to", "biological", "stimulation", ",", "whereas", "H2O2", "is", "able", "to", "partially", "bypass", "this", "requirement", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Treatment", "with", "wild-type", "and", "rough", "mutant", "forms", "of", "LPS", "and", "synthetic", "lipid", "A", "resulted", "in", "JNK", "activation", ",", "while", "pretreatment", "with", "the", "tyrosine", "kinase", "inhibitor", "herbimycin", "A", "inhibited", "this", "response", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "new", "gene", ",", "TINUR", ",", "was", "cloned", "from", "apoptotic", "PEER", "cells", "." ]

[ 0, 0, 1, 0, 1, 0, 0, 0, 0, 5, 6, 6, 0 ]

[ "Here", ",", "we", "describe", "the", "isolation", "and", "detailed", "characterization", "of", "the", "murine", "homolog", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Here", "we", "report", "that", "ATRA-induced", "expression", "of", "CD38", "antigen", "in", "myeloid", "cells", "is", "mediated", "through", "retinoic", "acid-alpha", "receptor", "(", "RAR", "alpha", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 0, 0, 0, 9, 10, 10, 0, 9, 10, 0, 0 ]

[ "PURPOSE", ":", "Sex-related", "influences", "have", "been", "implicated", "in", "the", "pathogenesis", "of", "vernal", "keratoconjunctivitis", "(", "VKC", ")", ",", "an", "allergic", "eosinophilic", "disease", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Moreover", ",", "the", "data", "comparing", "the", "effects", "of", "activated", "Ras", "and", "PKC", "mutants", "suggest", "that", "PKC-alpha", ",", "p21ras", ",", "and", "PKC-epsilon", "are", "not", "positioned", "linearly", "on", "a", "single", "signal", "transduction", "pathway", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "such", "cells", ",", "DNA", "binding", "activity", "of", "NF-kappa", "B", "can", "be", "detected", "without", "intentional", "stimulation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]

[ "Interestingly", ",", "PGE2", "or", "di-butyryl", "(", "Bt2", ")", "cAMP", "abolished", "the", "binding", "of", "NF-kappa", "B", "(", "p50/p65", ")", "heterodimer", "to", "the", "kappa", "B", "sequence", "in", "cells", "stimulated", "with", "anti-CD3", "mAb", "but", "not", "with", "PMA/A23187", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 1, 2, 2, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]

[ "Stimulation", "of", "the", "latently", "HIV-infected", "myelomonocytic", "cell", "line", "OM-10.1", "with", "C.", "neoformans", "and", "C.", "albicans", "in", "the", "presence", "of", "pooled", "human", "serum", "caused", "a", "ratio-dependent", "increase", "in", "HIV", "production", "." ]

[ 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Selection", "of", "down-regulated", "sequences", "along", "the", "monocytic", "differentiation", "of", "leukemic", "HL60", "cells", "." ]

[ 0, 0, 1, 2, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]

[ "HIV1", "infection", "of", "human", "monocytes", "and", "macrophages", "promotes", "induction", "or", "translocation", "of", "NF-KB-related", "factors", "." ]

[ 0, 0, 0, 7, 8, 0, 7, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Single", "point", "estimation", "of", "glucocorticoid", "receptors", "in", "lymphocytes", "of", "normal", "subjects", "and", "of", "children", "under", "long", "term", "glucocorticoid", "treatment", "." ]

[ 0, 0, 0, 0, 9, 10, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Phorbol", "ester", "reduces", "constitutive", "nuclear", "NF", "kappa", "B", "and", "inhibits", "HIV-1", "production", "in", "mature", "human", "monocytic", "cells", "." ]

[ 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]

[ "In", "order", "to", "define", "the", "roles", "of", "these", "two", "factors", ",", "which", "bind", "to", "the", "same", "kappa", "B", "enhancers", ",", "in", "transcription", "activation", "we", "have", "prepared", "somatic", "cell", "hybrids", "between", "IARC", "301.5", "and", "a", "murine", "myeloma", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 5, 6, 0 ]

[ "As", "an", "in", "vitro", "model", "we", "show", "that", "phosphorylation", "of", "p105", "impedes", "its", "ability", "to", "interact", "with", "NF-kappa", "B", ",", "as", "has", "been", "shown", "before", "for", "I", "kappa", "B", "alpha", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "An", "in", "vitro", "surrogate", "of", "IL-2", "immunotherapy", "is", "the", "incubation", "of", "fresh", "peripheral", "blood", "mononuclear", "cells", "(", "PBMC", ")", "from", "healthy", "individuals", "in", "IL-2", "for", "several", "days", ",", "resulting", "in", "the", "production", "of", "lymphokine", "-activated", "killer", "(", "LAK", ")", "activity", "in", "these", "cultures", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 7, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "results", "therefore", "demonstrate", "that", "the", "MHC", "class", "II", "gene", "silencing", "in", "somatic", "cell", "hybrids", "is", "due", "to", "an", "active", "suppression", "of", "one", "of", "the", "promoters", "of", "the", "CIITA", "gene", ",", "mediated", "by", "the", "epithelial", "cell", "fusion", "partner", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]

[ "A", "candidate", "gene", "to", "control", "thymocyte", "differentiation", ",", "T", "cell", "factor-1", "(", "TCF-1", ")", "*", "encodes", "a", "DNA-binding", "protein", "." ]

[ 0, 0, 0, 0, 0, 7, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 9, 10, 0 ]

[ "We", "also", "detected", "abnormally", "low", "levels", "of", "the", "signaling", "molecules", "T-cell", "receptor", "(", "TCR", ")", "-zeta", ",", "ZAP-70", "and", "p56lck", "in", "4", "of", "14", "breast", "cancer", "patients", ",", "i.e.", ",", "defects", "in", "T-cell", "signaling", "molecules", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 10, 10, 10, 10, 10, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "None", "of", "the", "DNA", "fragments", "investigated", "indicated", "interaction", "of", "EBNA-2", "with", "the", "DNA", "via", "protein-protein", "interactions", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]

[ "3-deazaadenosine", ",", "a", "S-adenosylhomocysteine", "hydrolase", "inhibitor", ",", "has", "dual", "effects", "on", "NF-kappaB", "regulation", "." ]

[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "Possible", "role", "of", "nuclear", "factor-kappa", "B", "activity", "in", "germline", "C", "epsilon", "transcription", "in", "a", "human", "Burkitt", "lymphoma", "B", "cell", "line", "." ]

[ 0, 0, 0, 9, 10, 10, 0, 0, 1, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0 ]

[ "An", "electrophoretic", "mobility", "shift", "assay", "employing", "AP-1", "and", "NF-kappaB", "consensus", "oligonucleotides", "was", "used", "to", "demonstrate", "that", "AP-1", "-binding", "activity", "increased", ",", "while", "constitutive", "NF-kappaB", "-binding", "activity", "was", "not", "enhanced", ",", "following", "2", "h", "of", "CD19", "cross-linking", "in", "1E8", "cells", ".", "Supershift", "experiments", "revealed", "that", "JunD", "and", "c-Fos", "proteins", "mediated", "anti-", "CD19", "induced", "AP-1", "-binding", "activity", "in", "1E8", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 5, 6, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 9, 0, 9, 0, 0, 0, 5, 6, 0 ]

[ "In", "neutrophils", ",", "TNF-alpha", "caused", "a", "gliotoxin-inhibitable", "activation", "of", "an", "inducible", "form", "of", "NF-kappaB", ",", "a", "response", "that", "may", "underlie", "the", "ability", "of", "TNF-alpha", "to", "delay", "apoptosis", "at", "later", "times", "(", "12-24", "h", ")", "and", "limit", "its", "early", "killing", "effect", "." ]

[ 0, 7, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "There", "was", "a", "normal", "increase", "in", "ACTH", ",", "cortisol", ",", "and", "GH", "(", "except", "in", "one", "obese", "patient", ")", "in", "response", "to", "insulin-induced", "hypoglycemia", ",", "while", "cortisol", "production", "was", "elevated", "in", "three", "patients", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Establishment", "and", "characterization", "of", "EBV-positive", "and", "EBV-negative", "primary", "effusion", "lymphoma", "cell", "lines", "harbouring", "human", "herpesvirus", "type-8", "." ]

[ 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0 ]

[ "Cloning", "of", "murine", "TCF-1", ",", "a", "T", "cell-specific", "transcription", "factor", "interacting", "with", "functional", "motifs", "in", "the", "CD3-epsilon", "and", "T", "cell", "receptor", "alpha", "enhancers", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 0, 1, 2, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0 ]

[ "The", "Oct-2", "transcription", "factor", "is", "a", "member", "of", "the", "POU", "(", "Pit-Oct-Unc", ")", "family", "of", "transcription", "factors", "and", "is", "expressed", "only", "in", "B", "lymphocytes", "and", "in", "neuronal", "cells", "but", "not", "in", "other", "cell", "types", "." ]

[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 10, 0, 0, 0, 0, 0, 7, 8, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "resting", "Raji", "cells", ",", "little", "to", "no", "binding", "to", "the", "X2", "box", "was", "observed", "." ]

[ 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0 ]

[ "In", "monocytes", ",", "lipopolysaccharide", "induces", "synthesis", "and", "activity", "of", "the", "85-kDa", "cytosolic", "phospholipase", "A2", "." ]

[ 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "HIV-1", "replication", "was", "increased", "by", "dopamine", ",", "which", "correlated", "with", "the", "increased", "levels", "of", "HIV-1", "transactivation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "After", "stimulation", "by", "PMA", ",", "RXR", "alpha", "expression", "increased", "in", "H9", "and", "U937", "cells", "but", "not", "in", "CEM", "cells", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 5, 0, 5, 6, 0, 0, 0, 5, 6, 0 ]

[ "The", "AP-1", "site", "at", "-150", "bp", ",", "but", "not", "the", "NF-kappa", "B", "site", ",", "is", "likely", "to", "represent", "the", "major", "target", "of", "protein", "kinase", "C", "in", "the", "interleukin", "2", "promoter", "." ]

[ 0, 1, 2, 0, 1, 2, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 1, 2, 2, 0 ]

[ "We", "have", "studied", "the", "adaptive", "mechanisms", "which", "occur", "at", "the", "level", "of", "the", "glucocorticoid", "receptor", "in", "glucocorticoid", "target", "tissues", "in", "patients", "with", "sepsis", "or", "septic", "shock", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Cytotoxicity", "was", "not", "demonstrated", "at", "these", "concentrations", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Stimulation", "of", "CR1", "or", "CR3", "induces", "a", "two-", "to", "fourfold", "increase", "in", "the", "amount", "of", "cell-associated", "and", "released", "p24", "Ag", "in", "cell", "cultures", "that", "was", "equivalent", "to", "that", "observed", "in", "control", "cultures", "triggered", "with", "LPS", "." ]

[ 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0 ]

[ "The", "results", "of", "the", "present", "study", "demonstrate", "that", "dysfunction", "of", "these", "genes", "also", "occurs", "during", "recurrence", "of", "glial", "tumors", "that", "were", "highly", "malignant", "at", "first", "presentation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Although", "both", "viruses", "establish", "latency", "in", "quiescent", "human-peripheral-blood", "T", "cells", ",", "the", "asymptomatic", "phase", "of", "HIV-2", "infection", "may", "be", "more", "prolonged", "than", "that", "of", "HIV-1", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "data", "suggest", "that", "a", "small", "number", "of", "GATA-1.05", "mutant", "hematopoietic", "progenitor", "cells", "begin", "to", "proliferate", "vigorously", "during", "early", "adulthood", ",", "but", "because", "the", "cells", "are", "unable", "to", "terminally", "differentiate", ",", "this", "leads", "to", "progenitor", "proliferation", "in", "the", "spleen", "and", "consequently", "death", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Expression", "of", "the", "MAP", "kinase-specific", "phosphatase", ",", "MKP-1", ",", "which", "blocks", "ERK", "activation", ",", "inhibited", "IL-2", "promoter", "and", "NF-AT", "-driven", "transcription", "stimulated", "by", "a", "calcium", "ionophore", "and", "PMA", ",", "and", "in", "addition", ",", "MKP-1", "neutralized", "the", "transcriptional", "enhancement", "caused", "by", "active", "Raf-1", "and", "MEK1", "expression", "." ]

[ 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 9, 0, 0, 0, 1, 2, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Recent", "work", "has", "shown", "that", "IL-10", "induces", "activation", "of", "the", "JAK", "-STAT", "signaling", "pathway", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 9, 0, 0, 0 ]

[ "The", "hormone", "delayed", "terminal", "differentiation", "into", "erythrocytes", ",", "which", "was", "assayed", "by", "morphology", ",", "hemoglobin", "accumulation", ",", "and", "the", "expression", "of", "genes", "characteristic", "for", "immature", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "Furthermore", ",", "cycloheximide", "displayed", "a", "similar", "capacity", "to", "enhance", "TNF-alpha", "induced", "neutrophil", "apoptosis", "even", "at", "time", "points", "when", "cycloheximide", "alone", "had", "no", "pro-apoptotic", "effect", ",", "suggesting", "that", "NF-kappaB", "may", "regulate", "the", "production", "of", "protein", "(", "s", ")", "which", "protect", "neutrophils", "from", "the", "cytotoxic", "effects", "of", "TNF-alpha", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 9, 0 ]

[ "Leukocyte", "integrins", "are", "fundamentally", "important", "in", "modulating", "adhesion", "to", "extracellular", "matrix", "components", "and", "to", "other", "cells", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Expression", "of", "Retinoid", "X", "Receptor", "alpha", "is", "increased", "upon", "monocytic", "cell", "differentiation", "." ]

[ 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "was", "in", "contrast", "to", "normal", "peripheral", "blood", "B", "lymphocytes", "or", "CD5+", ")", "B", "cells", "isolated", "from", "tonsils", ",", "in", "which", "this", "phosphorylation", "was", "absent", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Both", "RM", "and", "ChtM", "showed", "circadian", "rhythm", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Induction", "of", "transcription", "factors", "in", "human", "T", "lymphocytes", "by", "aspirin-like", "drugs", "." ]

[ 0, 0, 9, 10, 0, 7, 8, 8, 0, 0, 0, 0 ]

[ "Treatment", "of", "T", "cells", "with", "the", "selective", "PKC", "inhibitor", "GF109203X", "abrogates", "the", "PMA-induced", "IkB", "alpha", "phosphorylation/degradation", "irrespective", "of", "activation", "of", "Ca", "(", "2+", ")", "-dependent", "pathways", ",", "but", "not", "the", "phosphorylation", "and", "degradation", "of", "IkB", "alpha", "induced", "by", "TNF-alpha", ",", "a", "PKC", "-independent", "stimulus", "." ]

[ 0, 0, 7, 8, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0, 9, 0, 0, 0 ]

[ "Here", ",", "we", "have", "studied", "IL-2", "and", "IL-4", "signaling", "in", "B", "cell", "lines", "lacking", "JAK3", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 5, 6, 6, 0, 9, 0 ]

[ "All", "four", "complexes", "contain", "CREB", "and", "are", "bound", "to", "the", "cAMP", "response", "element", "(", "CRE", ")", "core", "sequence", "(", "TGACGTCA", ")", ",", "as", "indicated", "by", "antibody", "and", "oligonucleotide", "competition", "experiments", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Therefore", "the", "ACH-2", "cell", "line", "is", "a", "good", "candidate", "for", "studying", "the", "effects", "of", "drugs", "on", "HIV-1", "activation", "." ]

[ 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Epstein-Barr", "viral", "latency", "is", "disrupted", "by", "the", "immediate-early", "BRLF1", "protein", "through", "a", "cell-specific", "mechanism", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0 ]

[ "Binding", "of", "the", "cDNA", "fusion", "protein", ",", "similarly", "to", "the", "results", "obtained", "with", "purified", "Jurkat", "protein", ",", "was", "decreased", "by", "introduction", "of", "site-specific", "mutations", "in", "the", "DRE", "1", "regulatory", "sequence", "." ]

[ 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "T", "cell", "blasts", "treated", "with", "PMA", "are", "now", "responsive", "to", "IFN-gamma", "." ]

[ 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "After", "cellular", "activation", ",", "I", "kappa", "B", "alpha", "is", "rapidly", "degraded", "in", "concert", "with", "the", "induced", "nuclear", "translocation", "of", "NF-kappa", "B", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Leukemic", "blasts", "in", "the", "majority", "of", "cases", "shared", "unique", "morphologic", "features", "(", "deeply", "invaginated", "nuclear", "membranes", ",", "scant", "cytoplasm", "with", "fine", "azurophilic", "granularity", ",", "and", "finely", "granular", "Sudan", "black", "B", "and", "myeloperoxidase", "cytochemical", "reactivity", ")", "that", "were", "remarkably", "similar", "to", "those", "of", "acute", "promyelocytic", "leukemia", "(", "APL", ")", ";", "particularly", "the", "microgranular", "variant", "(", "FAB", "AML-M3v", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0 ]

[ "In", "CRF", "patients", ",", "Bmax", "and", "Kd", "in", "quiescent", "PBMC", "of", "the", "GC-sensitive", "group", "were", "6.04", "+/-", "2.35", "fmol/10", "(", "6", ")", "cells", "and", "3.49", "+/-", "1.72", "nM", ",", "respectively", ",", "while", "those", "in", "PBMC", "of", "the", "GC-resistant", "group", "were", "5.13", "+/-", "2.31", "fmol/10", "(", "6", ")", "cells", "and", "4.04", "+/-", "1.62", "nM", ",", "respectively", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "time", "course", "of", "SP1", "cleavage", "during", "anti-IgM-induced", "apoptosis", "is", "paralleled", "by", "an", "increase", "of", "caspase", "activity", "measured", "by", "DEVD-p-nitroanilide", "(", "DEVD-pNA", ")", "cleavage", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Resting", "B", "and", "T", "lymphocytes", "contain", "high", "levels", "of", "BCL-6", "mRNA", "." ]

[ 7, 8, 8, 8, 8, 0, 0, 0, 0, 3, 4, 0 ]

[ "In", "contrast", ",", "in", "vivo", "footprints", "on", "GT", "(", "CACCC", ")", "motifs", "differed", "between", "the", "cells", "expressing", "the", "fetal", "or", "the", "adult", "globin", "program", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "in", "normal", "subjects", ",", "the", "GR", "in", "MNL", "did", "not", "demonstrate", "circadian", "variation", ",", "in", "contrast", "to", "concentrations", "of", "plasma", "cortisol", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "antigenic", "specificities", "of", "lesion-derived", "CD4+", "T-cell", "clones", "are", "quite", "diverse", "and", "include", "at", "least", "10", "epitopes", "." ]

[ 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Both", "these", "signals", "were", "necessary", "for", "expression", "of", "the", "reporter", "gene", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "The", "prevalence", "of", "aneuploidy", "and", "overexpressed", "EGFR", "was", "significantly", "higher", "in", "the", "high", "risk", "women", "than", "in", "the", "25", "low", "risk", "controls", "(", "p", "<", "0.002", ")", ",", "whose", "median", "10", "year", "Gail", "risk", "was", "0.7", "%", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "While", "all", "the", "M10-expressing", "cell", "lines", "remained", "infectable", "by", "HIV-1", ",", "these", "same", "cells", "failed", "to", "support", "a", "productive", "replication", "cycle", "when", "infected", "with", "a", "cloned", "isolate", "of", "HIV-1", "." ]

[ 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "immunologically", "identified", "Stat1", ",", "Stat2", ",", "Stat3", ",", "and", "Stat5", "in", "human", "platelet", "lysates", "." ]

[ 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0 ]