id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
7832
[ "Recently", ",", "we", "have", "reported", "that", "the", "histogenesis", "of", "HD", "of", "the", "general", "population", "may", "be", "assessed", "by", "monitoring", "the", "expression", "pattern", "of", "BCL-6", ",", "a", "transcription", "factor", "expressed", "in", "germinal", "center", "(", "GC", ")", "B", "cells", ",", "and", "of", "CD138/syndecan-1", "(", "syn-1", ")", ",", "a", "proteoglycan", "associated", "with", "post-GC", ",", "terminal", "B-cell", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 5, 6, 6, 6, 6, 6, 6, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]
12715
[ "This", "review", "discusses", "the", "NF-kappaB", "transcription", "factor", "family", "in", "general", "and", "the", "association", "of", "NF-kappaB", "activation", "with", "cellular/molecular", "events", "of", "renal", "inflammation", "and", "fibrosis" ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15764
[ "Treatment", "of", "endothelial", "cells", "with", "LPS", "(", "1", "microgram/ml", ")", "stimulated", "transcription", "of", "ELAM-1", ",", "as", "shown", "by", "Northern", "blot", "analysis", ",", "and", "expression", "of", "membrane-associated", "ELAM-1", "and", "ICAM-1", ",", "as", "shown", "by", "quantitative", "immunofluorescence", "(", "both", "P", "<", "0.001", ",", "n", "=", "9", ")", "." ]
[ 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14848
[ "The", "cell", "system", "described", "in", "these", "experiments", "provides", "a", "tool", "for", "the", "detection", "of", "EBV", "reactivation", "and", "demonstrates", "the", "potential", "of", "the", "lytic", "regulatory", "gene", "BZLF", "1" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2 ]
18526
[ "In", "Jurkat", "T", "cells", ",", "the", "ZIP", "site", "serves", "as", "an", "activator", "for", "IL-2", "gene", "expression", ",", "and", "a", "combination", "of", "ZIP", "and", "NFAT", "binding", "sites", "is", "required", "for", "maximal", "IL-2", "promoter", "activity", "." ]
[ 0, 5, 6, 6, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 0, 0 ]
7749
[ "These", "data", "indicate", "that", "Lck", "and", "active", "MAPK", "do", "not", "affect", "IFN-alpha", "-induced", "growth", "arrest", "or", "induction", "of", "STAT1s1", "and", "-3", "DNA", "binding", "ability", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5553
[ "Bcl-2", "inhibits", "apoptosis", "induced", "by", "a", "variety", "of", "stimuli", ",", "including", "chemotherapy", "drugs", "and", "glucocorticoids", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4940
[ "BCR", "-induced", "increases", "in", "CD44", "mRNA", "expression", "and", "transcription", "levels", "are", "shown", "to", "occur", "in", "EGR1-expressing", "but", "not", "in", "nonexpressing", "subclones", "of", "the", "B-cell", "line", "WEHI-231", "." ]
[ 9, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0, 0, 5, 6, 5, 0 ]
7780
[ "This", "ability", "of", "CIITA", "to", "facilitate", "promoter", "occupation", "is", "undissociable", "from", "its", "transactivation", "potential", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12026
[ "The", "identification", "of", "this", "gene", "opens", "the", "way", "to", "studies", "of", "the", "physiologic", "mechanisms", "controlling", "reactvation", "of", "KSHV", "from", "latency", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5659
[ "The", "short", "truncated", "analog", "433-442A", "binds", "very", "poorly", "at", "both", "acidic", "and", "neutral", "pH", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6721
[ "Furthermore", ",", "the", "same", "cell", "lines", "were", "resistant", "to", "cytolytic", "action", "of", "other", "cytotoxic", "proteins", "secreted", "by", "LAK", "cells", "." ]
[ 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 5, 6, 0 ]
16749
[ "Of", "note", "was", "the", "associated", "emergence", "of", "second-site", "LTR", "revertants", "which", "involved", "an", "alteration", "of", "the", "TATA", "box", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
11649
[ "The", "hypothesis", "that", "the", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NF-AT", ")", "may", "influence", "HIV-1", "replication", "is", "therefore", "compelling", "given", "the", "tight", "correlation", "of", "HIV-1", "transcriptional", "induction", "to", "T", "cell", "activation", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18002
[ "Proteins", "in", "the", "first", "group", "contain", "multiple", "HMG", "boxes", ",", "are", "non-sequence-specific", ",", "and", "recognize", "structural", "features", "as", "found", "in", "cruciform", "DNA", "and", "cross-over", "DNA", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 0 ]
3791
[ "Ad5E1A", "-specific", "CTL", "activity", "could", "no", "longer", "be", "isolated", "from", "mice", "after", "injection", "of", "Ad5E1A-peptide", ",", "indicating", "that", "tolerization", "of", "Ad5E1A", "-specific", "CTL", "activity", "causes", "the", "enhanced", "tumor", "outgrowth", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15016
[ "This", "factor", "is", "Oct-1", "or", "an", "immunologically", "related", "octamer-binding", "protein", ",", "and", "it", "plays", "a", "role", "in", "coordinating", "the", "activity", "of", "several", "regulatory", "elements", "." ]
[ 0, 0, 0, 9, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
15732
[ "The", "response", "to", "antigen", "proceeds", "at", "the", "T", "helper", "cell", "level", "through", "two", "independent", "forms", "of", "cellular", "collaboration", ",", "contact", "and", "lymphokine", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
14788
[ "The", "number", "of", "gamma-positive", "cells", "and", "their", "fluorescence", "intensity", "were", "higher", "in", "UT-7", "Epo", "than", "in", "UT-7", "cells", "(", "0", "to", "17", "%", "barely", "positive", "cells", "and", "23", "to", "40", "%", "clearly", "positive", "cells", ",", "respectively", ")", ",", "indicating", "that", "the", "increase", "in", "globin", "mRNA", "observed", "in", "UT-7", "Epo", "is", "due", "to", "both", "an", "increase", "of", "gene", "expression", "per", "cell", "and", "an", "increase", "in", "numbers", "of", "cells", "containing", "gamma-globin", "." ]
[ 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
4669
[ "The", "ability", "to", "regulate", "AR", "gene", "transcription", "via", "the", "second", "messenger", "pathway", "is", "lost", "in", "the", "PC-3", "and", "DU-145", "cell", "lines", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]
18448
[ "These", "data", "point", "to", "a", "new", "mechanism", "for", "CsA-sensitive", "regulation", "of", "NFATp", "in", "which", "dephosphorylation", "is", "critical", "for", "DNA", "binding", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7180
[ "Quantitative", "assays", "demonstrated", "a", "direct", "temporal", "relationship", "between", "LMP-1", "protein", "levels", "and", "active", "NF-kappaB", "during", "the", "time", "course", "of", "infection", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
315
[ "The", "tyrosine", "kinase", "inhibitors", "genistein", "and", "herbimycin", "A", "block", "both", "integrin", "-mediated", "tyrosine", "phosphorylation", "and", "increases", "in", "IL-1", "beta", "message", "levels", ",", "indicating", "a", "causal", "relationship", "between", "the", "two", "events", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11016
[ "IL-1beta", "transcription", "was", "abrogated", ";", "in", "contrast", ",", "TGF-beta1", "mRNA", "synthesis", "was", "steroid", "resistant", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0 ]
10601
[ "Furthermore", ",", "the", "tyrosine", "phosphorylation", "of", "STAT1", "and", "the", "tyrosine", "kinases", "JAK1", "and", "JAK2", "was", "enhanced", "significantly", "in", "RGD-adherent", "monocytes", "compared", "with", "control", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 9, 0, 9, 0, 0, 0, 0, 7, 8, 0, 0, 7, 8, 0 ]
18242
[ "To", "understand", "better", "the", "expression", "of", "the", "GP", "Ib-IX-V", "complex", ",", "studies", "were", "undertaken", "to", "define", "the", "essential", "genetic", "elements", "supporting", "the", "expression", "of", "the", "alpha-subunit", "of", "the", "complex", "(", "GP", "Ib", "alpha", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0, 0 ]
7675
[ "Signaling", "through", "HLA", "class", "I", "molecules", "induced", "cyclin", "E", "-associated", "kinase", "activity", "within", "4", "h", "in", "quiescent", "endothelial", "cells", ",", "and", "appeared", "to", "mediate", "the", "inactivation", "of", "Rb", "." ]
[ 0, 0, 9, 10, 10, 10, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
2718
[ "In", "the", "bone", "marrow", ",", "it", "is", "preferentially", "expressed", "in", "myeloid", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
4088
[ "Cell-type-specific", "regulation", "of", "the", "human", "tumor", "necrosis", "factor", "alpha", "gene", "in", "B", "cells", "and", "T", "cells", "by", "NFATp", "and", "ATF-2/JUN", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 7, 8, 0, 7, 8, 0, 9, 0, 9, 0 ]
8341
[ "In", "this", "study", "we", "have", "characterized", "the", "expression", "of", "NF-AT", "cDNAs", "in", "murine", "mast", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 7, 8, 0 ]
268
[ "Expression", "of", "nucleoside", "diphosphate", "(", "NDP", ")", "kinase", ",", "which", "is", "homologous", "to", "the", "nm23", "gene", "product", "in", "a", "variety", "of", "species", ",", "has", "been", "found", "to", "be", "inversely", "associated", "with", "metastatic", "potential", "." ]
[ 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10944
[ "Our", "findings", "suggest", "that", "leukocyte-platelet", "adhesion", "contributes", "to", "the", "regulation", "of", "inflammatory", "responses", "in", "AMI", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17834
[ "Here", "we", "report", "the", "identification", "and", "importance", "of", "the", "same", "sequence", "in", "a", "non-cytokine", "gene", ",", "the", "human", "T", "cell", "receptor", "gamma", "(", "TCRG", ")", "enhancer", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 0 ]
688
[ "In", "the", "leukemic", "cells", "of", "patients", "without", "detectable", "TAL1", "rearrangements", ",", "TAL1", "transcription", "occurred", "in", "either", "a", "monoallelic", "(", "3", "of", "7", "patients", ")", "or", "a", "biallelic", "(", "4", "of", "7", "patients", ")", "fashion", "." ]
[ 0, 0, 7, 8, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16516
[ "In", "contrast", ",", "the", "human", "T", "cell", "line", ",", "IARC", "301", ",", "expresses", "these", "two", "genes", "constitutively", "and", "we", "have", "previously", "demonstrated", "that", "its", "growth", "depends", "on", "the", "autocrine", "production", "of", "this", "T", "cell", "growth", "factor", "and", "high", "affinity", "IL-2R", "." ]
[ 0, 0, 0, 0, 5, 6, 6, 6, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 10, 10, 0 ]
2314
[ "The", "DNA", "binding", "protein", "NF-kB", "is", "a", "central", "mediator", "in", "cytokine", "activation", "of", "HIV", "transcription", "." ]
[ 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
7545
[ "In", "this", "study", ",", "the", "influence", "of", "the", "sequences", "located", "between", "-3134", "and", "-2987", "on", "the", "transcriptional", "activity", "of", "the", "proIL-1beta", "gene", "in", "LPS-stimulated", "Raw", "264.7", "cells", "was", "examined", "in", "detail", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0 ]
12200
[ "Moreover", ",", "antisense", "oligodeoxynucleotides", "targeting", "either", "GATA-1", "or", "p45", "NF-E2", "proteins", "inhibited", "both", "protein", "expression", "and", "BA-induced", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16005
[ "We", "have", "therefore", "investigated", "the", "changes", "in", "protein", "kinase", "C", "(", "PKC", ")", "activity", "upon", "exposure", "of", "monocytes", "to", "M-CSF", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 7, 0, 9, 0 ]
10857
[ "Alternatively", ",", "the", "IL-4Ralpha", "chain", "may", "transduce", "intracellular", "signals", "that", "lead", "to", "Cepsilon", "gene", "transcription", "independently", "of", "its", "association", "with", "other", "chains", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2565
[ "We", "now", "demonstrate", "that", "v-src", "expression", "correlates", "with", "nuclear", "expression", "of", "a", "kappa", "B", "binding", "complex", "similar", "to", "that", "induced", "by", "phorbol", "ester", "and", "ionomycin", ",", "as", "detected", "by", "electrophoretic", "mobility", "shift", "assay", "using", "a", "variety", "of", "kappa", "B", "sites", "." ]
[ 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
9864
[ "RESULTS", ":", "After", "nonspecific", "stimulation", ",", "IL-5", "production", "by", "CD4+", "T", "cells", "from", "both", "atopic", "and", "nonatopic", "subjects", "with", "asthma", "was", "significantly", "enhanced", "compared", "with", "that", "by", "cells", "from", "healthy", "controls", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11076
[ "EMS", "supershift", "analyses", "have", "demonstrated", "that", "Sp1", "is", "involved", "in", "U1A", "formation", "while", "Sp3", "is", "involved", "in", "U1B", "and", "U2", "formation", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
4722
[ "Transient", "expression", "of", "the", "luciferase", "reporter", "gene", "linked", "to", "serially", "deleted", "sequences", "of", "the", "5'-flanking", "region", "of", "the", "IL-9", "gene", "has", "revealed", "several", "positive", "and", "negative", "regulatory", "elements", "involved", "in", "the", "basal", "and", "inducible", "expression", "of", "the", "IL-9", "gene", "in", "C5MJ2", "cells", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 5, 6, 0 ]
15500
[ "Synergistic", "suppression", "of", "T-cell", "proliferation", "was", "observed", "when", "various", "concentrations", "of", "DEX", "and", "PGE2", ",", "but", "not", "DEX", "and", "ISO", ",", "were", "added", "to", "cultures", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
295
[ "Temperature-induced", "down-regulation", "of", "the", "glucocorticoid", "receptor", "in", "peripheral", "blood", "mononuclear", "leucocyte", "in", "patients", "with", "sepsis", "or", "septic", "shock", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]
17588
[ "Nuclear", "factor", "of", "activated", "T-cells", "(", "NFAT-1", ")", "is", "a", "transcription", "factor", "which", "is", "considered", "to", "be", "an", "important", "regulator", "in", "early", "T-cell", "activation", "." ]
[ 9, 10, 0, 7, 8, 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17209
[ "Identification", "of", "a", "novel", "factor", "that", "interacts", "with", "an", "immunoglobulin", "heavy-chain", "promoter", "and", "stimulates", "transcription", "in", "conjunction", "with", "the", "lymphoid", "cell-specific", "factor", "OTF2", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 9, 0 ]
14880
[ "Overall", ",", "TSH-R", "transcript", "levels", "were", "low", "or", "absent", "in", "those", "thyroids", "in", "which", "expression", "of", "the", "major", "histocompatibility", "complex", "class", "I", "or", "II", "(", "MHC", "I", "or", "II", ")", "was", "high", ",", "thus", "establishing", "an", "inverse", "relation", "(", "MHC", "I", ",", "r", "=", "-0.791", ";", "P", "<", "0.01", ";", "MHC", "II", ",", "r", "=", "-0.784", ";", "P", "<", "0.01", ")", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16429
[ "METHOD", ":", "They", "measured", "the", "number", "of", "lymphocyte", "cytosolic", "glucocorticoid", "receptors", "and", "plasma", "cortisol", "concentrations", "in", "15", "consecutively", "admitted", "male", "combat", "Vietnam", "veterans", "with", "PTSD", "and", "in", "a", "normal", "comparison", "group", "of", "11", "subjects", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15556
[ "The", "chemiluminescent", "(", "CL", ")", "response", "of", "interferon-gamma-treated", "U937", "(", "IFN-U937", ")", "cells", "to", "sensitized", "target", "cells", "has", "been", "used", "to", "detect", "red", "cell", ",", "platelet", "and", "granulocyte", "antibodies", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 9, 10, 0 ]
13292
[ "Activation", "of", "this", "lipid", "kinase", "is", "able", "to", "induce", "critical", "Rac-1", "signaling", "pathways", "and", "can", "couple", "p21ras", "to", "cell", "survival", "mechanisms", "via", "the", "serine/threonine", "kinase", "Akt/PKB", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
2524
[ "IL-4", "did", "not", "exert", "significant", "influence", "on", "the", "induction", "of", "expression", "of", "IL-1-RA", "or", "various", "CSFs", "by", "IL-2", ",", "IL-3", ",", "and", "GM-CSF", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0 ]
16797
[ "Mutations", "at", "the", "B2", "site", "abolish", "this", "transcriptional", "activation", "." ]
[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0 ]
1910
[ "Activation", "of", "early", "growth", "response", "1", "gene", "transcription", "and", "pp90rsk", "during", "induction", "of", "monocytic", "differentiation", "." ]
[ 0, 0, 1, 2, 2, 2, 2, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
2525
[ "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]
[ 0, 0, 0, 0, 0, 0, 0 ]
9348
[ "Two", "other", "members", "of", "the", "family", "have", "been", "cloned", "more", "recently", ",", "A-myb", "and", "B-myb", ",", "which", "show", "sequence", "homology", "with", "c-myb", "in", "several", "domains", ",", "of", "which", "the", "DNA", "binding", "domain", "as", "well", "as", "other", "regulatory", "domains", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 9, 10, 0 ]
17778
[ "The", "proteolytic", "degradation", "of", "the", "inhibitory", "protein", "MAD3/I", "kappa", "B", "alpha", "in", "response", "to", "extracellular", "stimulation", "is", "a", "prerequisite", "step", "in", "the", "activation", "of", "the", "transcription", "factor", "NF-kappa", "B", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 10, 0 ]
3361
[ "NF-kappa", "B", ",", "a", "50", "kDa/65", "kDa", "(", "p50/p65", ")", "heterodimer", ",", "is", "a", "ubiquitous", "transcription", "factor", "involved", "in", "the", "positive", "regulation", "of", "various", "immune", "genes", "." ]
[ 9, 10, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
6908
[ "Activity", "against", "macrovascular", "EC", "(", "HUVEC", ")", "and", "microvascular", "EC", "(", "human", "bone", "marrow", "EC", "immortalized", "by", "SV40", ")", "antigens", "was", "detected", "by", "enzyme-linked", "immunosorbent", "assay", "." ]
[ 0, 0, 5, 6, 0, 5, 0, 0, 5, 6, 0, 5, 6, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10930
[ "This", "homologous", "mechanism", "of", "H2", "receptor", "desensitization", "was", "time", "dependent", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
7957
[ "We", "reasoned", "that", "selective", "IFN", "responsiveness", "of", "the", "first", "STAT", "family", "member", "(", "Stat1", ")", "and", "Stat1-dependent", "immune-response", "genes", "such", "as", "intercellular", "adhesion", "molecule-1", "(", "ICAM-1", ")", ",", "IFN", "regulatory", "factor-1", "(", "IRF-1", ")", ",", "and", "Stat1", "itself", "in", "airway", "epithelial", "cells", "provides", "a", "basis", "for", "detecting", "cytokine", "signaling", "abnormalities", "in", "inflammatory", "airway", "disease", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 1, 2, 2, 0, 0, 9, 10, 10, 0, 9, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 9, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
7419
[ "We", "thus", "report", "a", "hotspot", "for", "human", "IFNGR1", "small", "deletions", "that", "confer", "dominant", "susceptibility", "to", "infections", "caused", "by", "poorly", "virulent", "mycobacteria", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8907
[ "Blockade", "of", "this", "intracellular", "signalling", "event", "was", "associated", "with", "a", "reduction", "in", "the", "normal", "transendothelial", "migration", "response", "towards", "MCP-1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
10941
[ "Inhibition", "of", "binding", "by", "anti-P", "selectin", "antibodies", "reduced", "the", "effect", "of", "activated", "platelets", "on", "cytokine", "production", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 7, 8, 0, 9, 0, 0 ]
7496
[ "p38", "mitogen-activated", "protein", "kinase", "mediates", "signal", "integration", "of", "TCR", "/CD28", "costimulation", "in", "primary", "murine", "T", "cells", "." ]
[ 9, 10, 10, 10, 0, 0, 0, 0, 9, 9, 0, 0, 7, 8, 8, 8, 0 ]
2973
[ "In", "vertebrates", ",", "five", "distinct", "DNA", "binding", "subunits", "are", "currently", "known", "which", "might", "extensively", "heterodimerize", ",", "thereby", "forming", "complexes", "with", "distinct", "transcriptional", "activity", ",", "DNA", "sequence", "specificity", ",", "and", "cell", "type-", "and", "cell", "stage-specific", "distribution", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
13147
[ "Electrophoretic", "mobility", "shift", "assay", "of", "protein", "extracts", "from", "shock", "lungs", "exhibited", "an", "increase", "in", "Stat3", "activation", "with", "kinetics", "similar", "to", "IL-6", "mRNA", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 3, 4, 0 ]
2329
[ "These", "findings", "demonstrate", "that", "cross-linking", "of", "MHC", "class", "II", "molecules", "transduced", "the", "negative", "signals", "through", "intracellular", "mechanisms", "different", "from", "those", "present", "in", "the", "cross-linking", "of", "surface", "IgM", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
13950
[ "More", "than", "50", "%", "of", "TPO-treated", "UT-7/GMT", "cells", "positively", "stained", "for", "Hb", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 9, 0 ]
4345
[ "Inorganic", "lead", "activates", "NF-kappa", "B", "in", "primary", "human", "CD4+", "T", "lymphocytes", "." ]
[ 0, 0, 0, 9, 10, 0, 7, 8, 8, 8, 8, 0 ]
12029
[ "IL-2", "gene", "transcription", "in", "T", "cells", "requires", "both", "TCR", "and", "costimulatory", "signals", "." ]
[ 9, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]
16391
[ "Eight", "patients", "with", "dermatomyositis/polymyositis", "were", "examined", "to", "determine", "whether", "the", "number", "of", "GR", "in", "MNL", "could", "be", "down-regulated", "by", "their", "cognate", "ligands", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]
8295
[ "The", "tissue", "from", "both", "patients", "generated", "a", "polyclonal", "pattern", "of", "X", "chromosome", "inactivation", "of", "the", "human", "androgen", "receptor", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 2, 2, 0 ]
9707
[ "The", "pigment", "also", "inhibited", "apoptosis", "in", "dexamethasone-treated", "rat", "thymocytes", "and", "in", "UV-irradiated", "Jurkat", "cells", "as", "judged", "by", "DNA", "ladder", "formation", ",", "cellular", "morphological", "changes", ",", "and", "flow", "cytometry", "analysis", "." ]
[ 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18335
[ "In", "order", "to", "further", "understand", "the", "mechanisms", "directing", "the", "expression", "of", "these", "key", "regulators", "of", "hematopoiesis", ",", "we", "initiated", "a", "study", "investigating", "the", "transcription", "factors", "activating", "the", "expression", "of", "the", "granulocyte-macrophage", "colony-stimulating", "factor", "(", "GM-CSF", ")", "receptor", "alpha", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 0 ]
4458
[ "In", "this", "review", "we", "examine", "the", "structure", "and", "function", "of", "cytokine", "receptors", "and", "the", "signaling", "pathways", "involved", "in", "their", "regulation", "of", "gene", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8945
[ "In", "contrast", ",", "activation", "in", "THP-1", "cells", "occurred", "in", "the", "absence", "of", "vanadate", "and", "was", "unaffected", "by", "catalase", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
6417
[ "On", "the", "contrary", ",", "32Dcl3", "cells", "stably", "expressing", "AML1/ETO", "were", "completely", "resistant", "to", "differentiation", "and", "continued", "to", "grow", "in", "the", "presence", "of", "G-CSF", "." ]
[ 0, 0, 0, 0, 5, 6, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
18012
[ "Positive", "regulatory", "element", "I", "(", "PRE-I", ")", "is", "a", "strong", "enhancer", "element", "essential", "for", "expression", "of", "the", "human", "IL-4", "gene", "." ]
[ 1, 2, 2, 2, 0, 1, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
14946
[ "Minimally", "modified", "low", "density", "lipoprotein", "-induced", "inflammatory", "responses", "in", "endothelial", "cells", "are", "mediated", "by", "cyclic", "adenosine", "monophosphate", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]
11189
[ "Retinoic", "acid", "caused", "the", "leukemic", "cells", "to", "differentiate", "in", "vitro", "and", "in", "vivo", ",", "eliciting", "remissions", "of", "both", "the", "preleukemic", "state", "and", "APL", "in", "mice", "." ]
[ 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5724
[ "Mouse", ",", "rat", ",", "hamster", ",", "and", "human", "cells", "that", "were", "rendered", "cytolytic", "susceptible", "by", "E1A", "were", "also", "sensitized", "to", "CL-induced", "and", "chemically", "induced", "apoptosis", "." ]
[ 7, 8, 8, 8, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
573
[ "In", "GD", "patients", ",", "the", "responses", "of", "peripheral", "blood", "mononuclear", "cells", "(", "PBMC", ")", "and", "TSH", "receptor", "(", "TSHR", ")", "-specific", "T", "cell", "lines", "to", "recombinant", "human", "TSHR", "extracellular", "domain", ",", "thyroglobulin", ",", "and", "TSHR", "peptides", "were", "examined", "on", "the", "day", "of", "surgery", "or", "RAI", "therapy", "(", "day", "0", ")", "and", "also", "6-8", "weeks", "and", "3-6", "months", "thereafter", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 7, 0, 0, 5, 6, 6, 6, 6, 6, 6, 6, 6, 0, 9, 10, 10, 10, 10, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12084
[ "In", "PMA-treated", "THP-1", "cells", "we", "could", "detect", "three", "major", "transcription", "initiation", "sites", "as", "revealed", "by", "Nuclease", "Protection", "Assay", "carried", "out", "with", "two", "overlapping", "antisense", "RNA", "probes", "." ]
[ 0, 5, 6, 6, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0 ]
2176
[ "To", "test", "this", "hypothesis", ",", "light-chain", "gene", "structure", "was", "examined", "in", "pre-B", "cells", "transformed", "by", "temperature-sensitive", "mutants", "of", "the", "Abelson", "virus", "and", "in", "derivatives", "that", "survive", "at", "the", "nonpermissive", "temperature", "because", "they", "express", "a", "human", "BCL-2", "gene", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
4161
[ "Presence", "of", "a", "variant", "form", "of", "the", "estrogen", "receptor", "in", "peripheral", "blood", "mononuclear", "cells", "from", "normal", "individuals", "and", "lupus", "patients", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0 ]
8035
[ "DQalpha", "and", "DQbeta", "trans", "heterodimeric", "HLA-DQ", "molecules", "form", "in", "individuals", "heterozygous", "for", "the", "DQ2", "and", "DQ8", "specificities", "." ]
[ 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0 ]
9205
[ "Further", "optimization", "of", "culture", "conditions", ",", "type", "of", "Antigen", "Presenting", "Cells", "(", "APC", ")", ",", "peptides", ",", "use", "of", "stabilizers", "like", "beta", "2-m", "are", "still", "needed", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]
2934
[ "Apoptosis", "signaling", "pathways", "in", "normal", "T", "cells", ":", "differential", "activity", "of", "Bcl-2", "and", "IL-1beta-converting", "enzyme", "family", "protease", "inhibitors", "on", "glucocorticoid-", "and", "Fas-mediated", "cytotoxicity", "." ]
[ 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
14561
[ "The", "suppressor", "function", "was", "determined", "using", "[", "3H", "]", "thymidine", "incorporation", "into", "phytohemagglutinin-activated", "peripheral", "blood", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0 ]
9270
[ "This", "induction", "of", "C/EBP", "epsilon", "mRNA", "expression", "is", "transcriptionally", "mediated", "and", "occurs", "in", "the", "absence", "of", "synthesis", "of", "additional", "protein", "factors", "." ]
[ 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
16292
[ "We", "have", "isolated", "a", "human", "cDNA", "clone", "encoding", "a", "zinc", "finger", "protein", "(", "NF-E1", ")", "that", "binds", "to", "the", "negative-acting", "segment", "of", "the", "kappa", "E3", "'", "enhancer", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 2, 0 ]
11566
[ "RESULTS", ":", "No", "significant", "partial", "correlations", "of", "the", "number", "of", "the", "peripheral", "blood", "mononuclear", "cell", "glucocorticoid", "receptors", "(", "6821", "+/-", "5669", "binding", "sites", "per", "cell", ")", "and", "the", "affinity", "(", "Kd", ":", "16.5", "+/-", "13.51", "nmol/L", ")", "for", "the", "glucocorticoid", "receptors", "with", "the", "symptom", "score", "(", "placebo", ":", "4.3", "+/-", "2.45", "pts", ";", "fluticasone", ":", "2.4", "+/-", "1.55", "pts", ")", "after", "active", "treatment", "were", "found", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14275
[ "The", "slight", "increase", "in", "the", "percentage", "of", "CD4+CD45R0+", "cells", "remained", "significant", "even", "after", "covariant", "analysis", "taking", "age-related", "changes", "into", "account", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4805
[ "The", "expression", "of", "p45", "megakaryocytic", "lineage", "cells", ",", "p45", "mRNA", "is", "transcribed", "only", "from", "aNF-E2", "promoter", "." ]
[ 0, 0, 0, 9, 7, 8, 8, 0, 3, 4, 0, 0, 0, 0, 1, 2, 0 ]
8878
[ "T", "cell", "receptor", "engagement", "activates", "transcription", "factors", "important", "for", "cytokine", "gene", "regulation", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 1, 2, 0, 0 ]
4096
[ "Consistent", "with", "these", "results", ",", "quantitative", "DNase", "footprinting", "of", "the", "TNF-alpha", "promoter", "using", "increasing", "amounts", "of", "recombinant", "NFATp", "demonstrated", "that", "the", "-76", "site", "binds", "to", "NFATp", "with", "a", "higher", "affinity", "than", "the", "kappa", "3", "site", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 0, 0, 0, 1, 2, 0, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
14266
[ "Using", "monoclonal", "antibodies", "(", "mAbs", ")", "and", "flow", "cytometry", ",", "we", "studied", "a", "variety", "of", "surface", "receptors", "on", "lymphocyte", "subpopulations", "of", "workers", "with", "moderately", "increased", "body", "burdens", "of", "2", ",", "3", ",", "7", ",", "8-tetrachlorodibenzo-p-dioxin", "(", "TCDD", ")", "and", "of", "other", "polychlorinated", "dibenzo-p-dioxins", "and", "dibenzofurans", "(", "PCDD/PCDF", ")", ",", "expressed", "here", "as", "International-Toxicity", "Equivalencies", "(", "I-TE", ")", "." ]
[ 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2285
[ "IL-4", "may", "mediate", "its", "biological", "effects", ",", "at", "least", "in", "part", ",", "by", "activating", "a", "tyrosine-phosphorylated", "DNA", "binding", "protein", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]