Datasets:

---

siddharthtumre

/

jnlpba-split

like 0

[ "Anti-", "HBx", "antibody", "titers", "as", "revealed", "by", "peptide", "ELISAs", "were", "highest", "and", "most", "frequent", "in", "patients", "with", "chronic", "hepatitis", "and", "usually", "low", "in", "acutely", "infected", "patients", "and", "asymptomatic", "carriers", "." ]

[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Together", "these", "data", "suggest", "that", "ETS1", "may", "be", "involved", "in", "mediating", "the", "increased", "GM-CSF", "production", "associated", "with", "T", "cell", "activation", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 7, 8, 0, 0 ]

[ "The", "Epstein-Barr", "virus", "nuclear", "antigen", "2", "interacts", "with", "an", "EBNA2", "responsive", "cis-element", "of", "the", "terminal", "protein", "1", "gene", "promoter", "." ]

[ 0, 9, 10, 10, 10, 10, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 2, 2, 0 ]

[ "This", "review", "considers", "the", "evidence", "for", "different", "theories", "of", "the", "histogenesis", "of", "endometriosis", "and", "discusses", "possible", "immune", "factors", "that", "may", "be", "involved", "in", "the", "pathophysiology", "of", "the", "disease", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Here", "we", "provide", "evidence", "that", "this", "transformation", "is", "the", "result", "of", "double", "infection", "of", "a", "cell", "with", "two", "virions", ",", "the", "P3HR1", "virus", "genome", "and", "a", "mini-EBV", "plasmid", "carrying", "the", "chimeric", "EBNA2", "gene", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0 ]

[ "GM2", "defines", "a", "binding", "site", "for", "protein", "(", "s", ")", "whose", "binding", "is", "inducible", "by", "PMA", "." ]

[ 1, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "clinics", "these", "molecules", "are", "also", "used", "for", "their", "potencies", "in", "inducing", "apoptosis", "of", "malignant", "lymphoid", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "Blockade", "of", "T-cell", "activation", "by", "dithiocarbamates", "involves", "novel", "mechanisms", "of", "inhibition", "of", "nuclear", "factor", "of", "activated", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0 ]

[ "PG490", "(", "triptolide", ")", "is", "a", "diterpene", "triepoxide", "with", "potent", "immunosuppressive", "and", "antiinflammatory", "properties", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "this", "report", "we", "have", "examined", "the", "efficacy", "of", "the", "gold", "compound", "AuTG", "as", "an", "inhibitor", "of", "HIV", "replication", "in", "latently", "infected", "OM10.1", "and", "Ach2", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0 ]

[ "On", "the", "contrary", ",", "there", "was", "no", "significant", "difference", "between", "the", "phosphate-supplemented", "patients", "(", "58.3", "+/-", "2.7", ")", "and", "controls", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "cognate", "interaction", "between", "T", "cells", "and", "antigen-presenting", "cells", "(", "APCs", ")", ",", "mediated", "by", "major", "histocompatibility", "complex", "(", "MHC", ")", "class", "II", "molecules", ",", "results", "in", "the", "delivery", "of", "activation", "signals", "to", "the", "APC", "." ]

[ 0, 0, 0, 0, 7, 8, 0, 7, 8, 0, 7, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]

[ "If", "GATA-1", "-red", "cells", "were", "available", ",", "the", "analyses", "would", "involve", "the", "actual", "transcription", "of", "or", "chromatin", "structure", "surrounding", "the", "globin", "genes", "." ]

[ 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "Conversely", ",", "SCL", "expression", "was", "up-regulated", "by", "Epo", "and", "further", "increased", "by", "haemin", "and", "delta-ALA", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "T", "cell", "responses", "to", "some", "nuclear", "antigens", ",", "particularly", "U1RNP", ",", "have", "been", "detected", "in", "patients", "with", "systemic", "lupus", "erythematosus", "(", "SLE", ")", "and", "in", "healthy", "subjects", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "addition", "of", "mifepristone", "or", "caspase-3", "inhibitor", "could", "partially", "abrogate", "GC-induced", "apoptosis", "as", "well", "as", "GC-induced", "inhibition", "of", "IL-1beta", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "NF-kB", "levels", "were", "higher", "in", "unstimulated", "U1", "cells", "as", "compared", "to", "the", "parent", "cell", "line", "U937", "." ]

[ 9, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 5, 6, 6, 5, 0 ]

[ "However", ",", "the", "mechanism", "by", "which", "E", "(", "2", ")", "downregulates", "TNF", "production", "is", "presently", "unknown", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]

[ "We", "now", "show", "that", "the", "core", "contains", "a", "single", "critical", "c-Myb", "binding", "site", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]

[ "In", "the", "presence", "of", "an", "anti-STAT-1", "Ab", ",", "the", "band", "was", "supershifted", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]

[ "Glucocorticoids", "have", "an", "inhibitory", "effect", "on", "inflammatory", "and", "immune", "responses", ",", "and", "this", "may", "be", "through", "the", "modulation", "of", "transcription", "factor", "binding", "to", "DNA", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]

[ "Various", "gene", "products", "from", "other", "viruses", "(", "HTLV-1", ",", "HSV", ",", "EBV", ",", "CMV", ",", "HBV", ",", "and", "HHV-6", ")", "can", "also", "enhance", "HIV-1", "long", "terminal", "repeat", "(", "LTR", ")", "-driven", "reporter", "gene", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 1, 2, 0, 0 ]

[ "We", "studied", "the", "functional", "interaction", "between", "human", "embryonic", "zeta", "2", "globin", "promoter", "and", "the", "alpha", "globin", "regulatory", "element", "(", "HS-40", ")", "located", "40", "kb", "upstream", "of", "the", "zeta", "2", "globin", "gene", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 1, 2, 2, 2, 0, 1, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 2, 0 ]

[ "However", ",", "these", "two", "decoy", "oligodeoxynucleotides", "together", "almost", "completely", "abrogated", "IL-4", "-induced", "germline", "Cepsilon", "transcription", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 1, 0, 0, 0 ]

[ "HIV", "type", "1", "protease", "activation", "of", "NF-kappa", "B", "within", "T", "lymphoid", "cells", "." ]

[ 0, 0, 0, 9, 0, 0, 9, 10, 0, 7, 8, 8, 0 ]

[ "Tumor", "necrosis", "factor", "receptor", "expression", "and", "signal", "transduction", "in", "HIV-1-infected", "cells", "." ]

[ 9, 10, 10, 10, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "These", "results", "suggest", "that", "targeting", "IFN", "synthesis", "to", "HIV-1-infected", "cells", "is", "an", "attainable", "goal", "and", "that", "autocrine", "IFN", "synthesis", "results", "in", "a", "long-lasting", "and", "permanent", "suppression", "of", "HIV-1", "replication", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "protein", "tyrosine", "kinase", "activity", "of", "the", "v-abl", "oncogene", "has", "been", "demonstrated", "to", "subvert", "the", "normal", "second", "messenger", "systems", "used", "by", "lymphoid", "cells", "for", "growth", "and", "differentiation", "." ]

[ 0, 9, 10, 10, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]

[ "Decreased", "Mn-SOD", "expression", "was", "associated", "with", "decreased", "levels", "of", "glutathione", "and", "a", "lower", "ratio", "of", "reduced", ":", "oxidized", "glutathione", "." ]

[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "asked", "whether", "dexamethasone", "(", "Dex", ")", "and", "cyclosporin", "A", "(", "CsA", ")", "inhibit", "IL-2", "gene", "transcription", "by", "interfering", "with", "the", "activity", "of", "nuclear", "proteins", "that", "bind", "to", "the", "IL-2", "promoter", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "this", "study", ",", "we", "have", "developed", "an", "in", "vitro", "model", "in", "which", "isolated", "lung", "cells", "can", "be", "submitted", "to", "a", "prolonged", "cyclic", "pressure-stretching", "strain", "resembling", "that", "of", "conventional", "mechanical", "ventilation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0 ]

[ "ADT", ",", "a", "pro-glutathione", "antioxidant", ",", "was", "observed", "to", "be", "capable", "of", "modulating", "NF-kappa", "B", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]

[ "The", "binding", "of", "ISGF3", "(", "IFN-stimulated", "gene", "factor", "3", ")", "to", "the", "conserved", "IFN-stimulated", "response", "element", "(", "ISRE", ")", "results", "in", "transcriptional", "activation", "." ]

[ 0, 0, 0, 9, 0, 9, 10, 10, 10, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0 ]

[ "Recently", ",", "it", "has", "been", "shown", "that", "RelB", "knockout", "mice", "have", "no", "dendritic", "cells", "(", "DC", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 0, 7, 0, 0 ]

[ "The", "data", "show", "that", "unstimulated", "human", "peripheral", "B", "cells", "express", "mRNA", "of", "the", "RA", "receptor", "alpha", ",", "beta", ",", "and", "gamma", "." ]

[ 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0 ]

[ "Observations", "such", "as", "these", "encourage", "the", "speculation", "that", "there", "may", "be", "subtle", "differences", "in", "the", "regulation", "of", "HIV-1", "and", "HIV-2", "expression", "that", "may", "be", "relevant", "to", "the", "possible", "longer", "latency", "and", "reduced", "pathogenicity", "of", "HIV-2", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Nonspecific", "protein", "kinase", "inhibition", "inhibited", "NF-kappaB", "activation", "and", "TNF-alpha", "release", ",", "while", "specific", "PKC", "inhibition", "with", "Bis", "had", "no", "effect", "on", "LPS-induced", "NF-kappaB", "DNA", "binding", "or", "TNF-alpha", "release", "." ]

[ 0, 9, 10, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0 ]

[ "Hemorrhagic", "shock", "(", "HS", ")", "initiates", "an", "inflammatory", "cascade", "that", "includes", "the", "production", "of", "cytokines", "and", "recruitment", "of", "neutrophils", "(", "PMN", ")", "and", "may", "progress", "to", "organ", "failure", ",", "inducing", "acute", "respiratory", "distress", "syndrome", "(", "ARDS", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 7, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Freshly", "isolated", "monocytes", "treated", "with", "the", "protein", "phosphatase", "inhibitor", "okadaic", "acid", "secreted", "high", "levels", "of", "IL-6", "protein", ",", "which", "coincided", "with", "enhanced", "binding", "activity", "of", "NF-kappa", "B", "as", "well", "as", "with", "phosphorylation", "and", "activation", "of", "the", "ERK1/2", "and", "JNK", "proteins", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "The", "absence", "of", "BSAP", ",", "TCF-1", ",", "and", "GATA-3", "clearly", "indicates", "an", "underlying", "difference", "between", "H-RS", "cells", "and", "lymphoid", "cells", "." ]

[ 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 5, 6, 0, 7, 8, 0 ]

[ "Pulse-field", "gel", "electrophoresis", "(", "PFGE", ")", "analysis", "showed", "that", "these", "genes", "are", "physically", "located", "within", "a", "DNA", "fragment", "of", "250", "kb", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 0 ]

[ "The", "expression", "of", "transiently", "transfected", "expression", "vectors", "under", "the", "control", "of", "the", "long", "terminal", "repeat", "(", "LTR", ")", "of", "the", "human", "immunodeficiency", "virus", "(", "HIV", ")", "or", "its", "enhancer", "sequence", "and", "the", "translocation", "of", "the", "HIV", "enhancer-binding", "protein", "NF-kappa", "B", "were", "analyzed", "in", "two", "human", "T-cell", "clones", "stimulated", "through", "their", "T-cell", "receptor", "complex", "or", "by", "tumor", "necrosis", "factor", "or", "phorbol", "12-myristate", "13-acetate", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 10, 10, 9, 10, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0 ]

[ "Exposure", "of", "CML", "cells", "to", "IFN-alpha", "diminished", "the", "effect", "of", "the", "CML", "cytoplasmic", "proteins", "on", "these", "nuclear", "protein-DNA", "complexes", "." ]

[ 0, 0, 7, 8, 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 0 ]

[ "In", "the", "present", "study", "we", "have", "performed", "electrophoretic", "mobility-shift", "assays", "to", "investigate", "the", "pattern", "of", "protein", "binding", "to", "a", "150", "bp", "fragment", "of", "the", "proximal", "5'-flanking", "region", "of", "the", "human", "monoamine", "oxidase", "B", "gene", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 2, 2, 0 ]

[ "Following", "culture", "with", "ATRA", ",", "increased", "CD38", "protein", "levels", "were", "also", "observed", "in", "normal", "CD34+", "bone", "marrow", "cells", ",", "but", "not", "on", "normal", "circulating", "granulocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "The", "variant", "Id-3L", "protein", "is", "functionally", "distinguishable", "from", "conventional", "Id-3", "since", "in", "in", "vitro", "DNA", "mobility", "shift", "assays", ",", "it", "was", "greatly", "impaired", "in", "its", "ability", "to", "abrogate", "binding", "of", "the", "basic", "helix-loop-helix", "protein", ",", "E47", ",", "to", "an", "E", "box", "recognition", "sequence", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "Activation", "of", "Ca", "(", "2+", ")", "-dependent", "pathways", "alone", "do", "not", "result", "in", "the", "phosphorylation", "and/or", "degradation", "of", "IkB", "alpha", "in", "Jurkat", "T", "or", "in", "U937", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 5, 6, 0, 0, 5, 6, 0 ]

[ "Recently", ",", "we", "reported", "that", "HIV-1", "tat", "downregulates", "MIP-1", "alpha", "expression", "in", "Jurkat", "T-cells", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 5, 6, 0 ]

[ "Here", ",", "we", "demonstrate", "the", "testosterone", "responsiveness", "of", "murine", "splenic", "T", "cells", "in", "vitro", "as", "well", "as", "the", "presence", "of", "unconventional", "cell", "surface", "receptors", "for", "testosterone", "and", "classical", "intracellular", "AR", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 9, 10, 10, 0 ]

[ "The", "Tax1-inducible", "transcription", "factors", "identified", "here", "are", "encoded", "by", "the", "members", "of", "immediate", "early", "genes", "under", "the", "control", "of", "growth", "signals", "." ]

[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0 ]

[ "Expression", "of", "the", "class", "A", "macrophage", "scavenger", "receptor", "(", "MSR", ")", "contributes", "to", "the", "uptake", "of", "modified", "low", "density", "lipoproteins", "(", "LDL", ")", "by", "macrophages", "and", "transformation", "of", "these", "cells", "into", "lipid-laden", "foam", "cells", ",", "which", "characterize", "atherosclerosis", "." ]

[ 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 7, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0 ]

[ "Both", "primary", "activation", ",", "with", "phytohemagglutinin", "or", "antibodies", "to", "CD3", ",", "and", "costimulation", ",", "provided", "by", "pairs", "of", "CD2", "antibodies", "or", "B7-positive", "(", "B", "cells", ")", "or", "B7-negative", "(", "endothelial", ")", "accessory", "cells", ",", "are", "mediated", "through", "the", "same", "cis-elements", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 8, 8, 8, 0, 7, 8, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0, 1, 0 ]

[ "The", "finding", "of", "Tax", "mutants", "segregating", "these", "two", "pathways", "suggested", "that", "the", "NF-kappaB", "pathway", "was", "essential", "for", "IL-2", "-independent", "growth", "of", "CTLL-2", "cells", "while", "the", "CRE", "pathway", "was", "unnecessary", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 7, 8, 0, 0, 1, 0, 0, 0, 0 ]

[ "These", "findings", "demonstrate", "that", "TGF-beta", "decreases", "B", "lymphocyte", "Ig", "secretion", "by", "inhibiting", "the", "synthesis", "of", "Ig", "mRNA", "and", "inhibiting", "the", "switch", "from", "the", "membrane", "form", "to", "the", "secreted", "forms", "of", "mu", "and", "gamma", "mRNA", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 3, 4, 0, 3, 4, 4, 4, 0 ]

[ "Identification", "of", "the", "pathways", "activated", "by", "LMP-1", "to", "result", "in", "posttranslational", "modifications", "of", "I", "kappa", "B", "alpha", "will", "aid", "in", "determining", "the", "role", "of", "this", "virus-host", "cell", "protein", "interaction", "in", "Epstein-Barr", "virus-mediated", "oncogenesis", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "E3330", "inhibited", "this", "induced", "promoter", "activity", "in", "a", "dose-dependent", "manner", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Pax-5", "encodes", "the", "transcription", "factor", "BSAP", "which", "plays", "an", "essential", "role", "in", "early", "B", "cell", "development", "and", "midbrain", "patterning", "." ]

[ 1, 0, 0, 9, 10, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Tyrosine", "kinase", "-dependent", ",", "and", "not", "protein", "kinase", "C", "-dependent", ",", "pathways", "mediate", "CD23", "-triggered", "NF-kappaB", "activation", "but", "do", "not", "participate", "in", "the", "direct", "phosphorylation", "of", "IkappaBalpha", "." ]

[ 9, 10, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "The", "CRO-AP/3", "and", "CRO-AP/5", "cell", "lines", "may", "provide", "a", "valuable", "model", "for", "clarifying", "the", "pathogenesis", "of", "PEL", "." ]

[ 0, 5, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0 ]

[ "Activator", "protein", "(", "AP", ")", "-1", "family", "proteins", "interacted", "with", "CLE0", ",", "P", ",", "P2", "and", "P4", "." ]

[ 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 1, 0, 0, 0, 1, 0, 1, 0 ]

[ "Cell-mediated", "immunity", "plays", "an", "essential", "role", "in", "the", "control", "of", "infection", "with", "the", "human", "cytomegalovirus", "(", "HCMV", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "Th2", "cells", ",", "IL-4", "gene", "expression", "is", "tightly", "controlled", "at", "the", "level", "of", "transcription", "by", "the", "coordinated", "binding", "of", "multiple", "transcription", "factors", "to", "regulatory", "elements", "in", "the", "proximal", "promoter", "region", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "These", "binding", "sites", "have", "similar", "sequences", "and", "multiple", "copies", "of", "the", "binding", "sites", "confer", "tissue-specific", "down-regulation", "when", "attached", "to", "a", "minimal", "lox", "promoter", "fragment", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "Physical", "interaction", "of", "AML1", "with", "BSAP", "correlates", "with", "functional", "cooperativity", "in", "transfection", "studies", "where", "AML1", "and", "BSAP", "synergistically", "activate", "blk", "promoter", "transcription", "by", "more", "than", "50-fold", "." ]

[ 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0 ]

[ "Antiserum", "specific", "for", "NF-kappa", "B", "binding", "proteins", ",", "but", "not", "c-rel-specific", "antiserum", ",", "disrupted", "heterodimer", "complex", "formation", "." ]

[ 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]

[ "In", "this", "study", ",", "we", "investigated", "the", "mechanism", "by", "which", "IL-10", "downregulates", "expression", "of", "intercellular", "adhesion", "molecule-1", "(", "ICAM-1", ")", "on", "the", "cell", "surface", "of", "normal", "human", "monocytes", "activated", "with", "interferon-gamma", "(", "IFN-gamma", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 9, 0, 9, 0, 0 ]

[ "Dominant", "negative", "forms", "of", "Stat1alpha", "or", "Stat3", "promoted", "the", "EPO", "-induced", "erythroid", "differentiation", "of", "UT-7/GM", "cells", ",", "even", "in", "the", "presence", "of", "granulocyte-macrophage", "colony-stimulating", "factor", ",", "although", "this", "cytokine", "never", "induced", "erythroid", "differentiation", "of", "the", "parent", "UT-7/GM", "cells", "with", "or", "without", "EPO", "." ]

[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 9, 0 ]

[ "The", "human", "myeloid", "cell", "nuclear", "differentiation", "antigen", "(", "MNDA", ")", "is", "expressed", "constitutively", "in", "cells", "of", "the", "myeloid", "lineage", ",", "appearing", "in", "myeloblast", "cells", "in", "some", "cases", "of", "acute", "myeloid", "leukemia", "and", "consistently", "being", "detected", "in", "promyelocyte", "stage", "cells", "as", "well", "as", "in", "all", "later", "stage", "cells", "including", "peripheral", "blood", "monocytes", "and", "granulocytes", "." ]

[ 0, 9, 10, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 7, 8, 8, 0, 7, 8, 8, 0, 7, 0 ]

[ "Injection", "of", "SEA", "to", "adult", "mice", "activates", "CD4+", "T", "cells", "expressing", "certain", "T-cell", "receptor", "(", "TCR", ")", "variable", "region", "beta-chain", "families", "and", "induces", "strong", "and", "rapid", "production", "of", "interleukin", "2", "(", "IL-2", ")", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 7, 8, 8, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "We", "present", "evidence", "that", "the", "development", "of", "thymic", "DC", "and", "of", "T-lineage", "cells", "is", "linked", "via", "a", "common", "precursor", "at", "an", "early", "stage", "of", "thymocyte", "development", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "After", "T", "cell", "activation", ",", "the", "phosphorylation", "of", "Rb", "results", "in", "the", "release", "of", "Elf-1", ",", "which", "is", "correlated", "temporally", "with", "the", "activation", "of", "Elf-1", "-mediated", "transcription", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]

[ "Our", "results", "suggest", "that", "a", "similar", "phenomenon", "may", "occur", "in", "BL", "in", "vivo", "and", "indicate", "that", "the", "operational", "definition", "of", "EBV", "latencies", "is", "not", "easily", "applied", "to", "human", "tumors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "results", "indicate", "that", "both", "a", "decrease", "and", "an", "increase", "of", "human", "motor", "activity", "resulted", "in", "significant", "changes", "of", "specific", "glucocorticoid", "binding", "which", "were", "not", "influenced", "by", "changes", "of", "circulating", "hormone", "concentrations", "in", "blood", "but", "by", "some", "other", "factors", "affected", "by", "physical", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Anaphylatoxins", "C5a", "and", "C3a", "induce", "nuclear", "factor", "kappaB", "activation", "in", "human", "peripheral", "blood", "monocytes", "." ]

[ 9, 9, 0, 9, 0, 9, 10, 10, 0, 0, 7, 8, 8, 8, 0 ]

[ "In", "addition", ",", "BSAP", "was", "found", "to", "be", "the", "only", "abundant", "DNA-binding", "activity", "of", "B-cell", "nuclear", "extracts", "that", "interacts", "with", "the", "CD19", "promoter", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "Nuclei", "of", "lymphocytes", "from", "FDC", "clusters", "were", "negative", "." ]

[ 0, 0, 7, 0, 7, 0, 0, 0, 0 ]

[ "Inhibition", "of", "activation", "of", "transcription", "factor", "AP-1", "by", "CD28", "signalling", "in", "human", "T-cells", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 7, 8, 0 ]

[ "Although", "it", "has", "been", "reported", "that", "there", "are", "some", "T", "cell", "lines", "that", "produce", "IFN-gamma", "in", "response", "to", "IL-2", "and", "IL-12", "stimulation", ",", "there", "has", "as", "yet", "been", "no", "report", "of", "a", "natural", "killer", "(", "NK", ")", "cell", "line", "that", "responds", "in", "a", "similar", "manner", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0 ]

[ "All", "these", "motifs", "are", "essential", "and", "collectively", "control", "transcriptional", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "report", "that", "activation", "of", "the", "two", "transcription", "factors", "NF-kappa", "B", "and", "AP-1", "is", "crucially", "involved", "in", "FasL", "expression", "induced", "by", "etoposide", ",", "teniposide", ",", "and", "UV", "irradiation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Since", "the", "human", "genomic", "sterol", "regulatory", "element", "(", "SRE", ")", "has", "been", "shown", "to", "regulate", "various", "key", "genes", "involved", "in", "this", "phenomenon", ",", "the", "present", "study", "revealed", "the", "existence", "of", "a", "unique", "47", "kDa", "protein", "factor", "having", "affinity", "for", "this", "SRE", "sequence", "in", "lymphocytes", "from", "normal", "subjects", ",", "as", "well", "as", "its", "absence", "in", "lymphocytes", "from", "untreated", "CML", "patients", "." ]

[ 0, 0, 1, 2, 2, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 1, 2, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]

[ "The", "signals", "controlling", "the", "expression", "of", "the", "receptor", "protein", "for", "1", "alpha", ",", "25-dihydroxyvitamin", "D3", "in", "normal", "human", "lymphocytes", "and", "the", "relationship", "of", "this", "protein", "to", "the", "classical", "vitamin", "D", "receptor", "were", "examined", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0 ]

[ "However", ",", "exposure", "of", "U-937", "cells", "to", "1", ",", "25-", "(", "OH", ")", "2D3", "increased", "by", "200", "%", "the", "level", "of", "IL-1", "beta", "mRNA", "detected", "and", "decreased", "by", "three", "orders", "of", "magnitude", "the", "concentration", "of", "LPS", "required", "to", "achieve", "steady", "state", "mRNA", "levels", "equivalent", "to", "those", "observed", "in", "U-937", "cells", "not", "preincubated", "with", "the", "hormone.2+o" ]

[ 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0 ]

[ "Recently", ",", "the", "egr-1", "promoter", "has", "been", "shown", "to", "be", "highly", "responsive", "to", "the", "diverse", "biochemical", "signals", "generated", "by", "antigen", "and", "cytokines", "in", "cells", "of", "the", "immune", "system", "." ]

[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]

[ "Recently", ",", "we", "reported", "cases", "of", "angioimmunoblastic", "T-cell", "lymphoma", "(", "AITL", ")", "with", "hyperplastic", "GCs", "(", "AITL/GC", ")", ",", "and", "observed", "that", "borders", "of", "enlarged", "GCs", "were", "ill", "defined", ",", "with", "features", "suggestive", "of", "an", "outward", "migration", "of", "GC", "cells", "to", "surrounding", "interfollicular", "zones", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]

[ "In", "the", "peripheral", "blood", "lymphocytes", "an", "even", "more", "striking", "downregulation", "of", "the", "GR", "by", "its", "cognate", "ligand", "was", "documented", "(", "30.3", "+/-", "26.5", "and", "8.8", "+/-", "5", "amol", "GR", "mRNA", "/microg", "RNA", ",", "respectively", ";", "P", "<", ".001", ")", ",", "possibly", "reflecting", "differences", "in", "glucocorticoid", "sensitivity", "between", "tissues", "." ]

[ 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Glucocorticoid-induced", "apoptosis", "and", "regulation", "of", "NF-kappaB", "activity", "in", "human", "leukemic", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 8, 8, 0 ]

[ "(", "iii", ")", "LMP1", "expression", "in", "Daudi", "and", "P3HR-1-infected", "cells", "was", "controlled", "at", "the", "mRNA", "level", ",", "and", "EBNA-2", "expression", "in", "Daudi", "cells", "increased", "LMP1", "mRNA", "." ]

[ 0, 0, 0, 9, 0, 0, 5, 0, 5, 6, 0, 0, 0, 0, 3, 0, 0, 0, 9, 0, 0, 5, 6, 0, 3, 4, 0 ]

[ "Human", "T-cell", "leukemia", "virus", "type", "I", "Tax", "associates", "with", "and", "is", "negatively", "regulated", "by", "the", "NF-kappa", "B2", "p100", "gene", "product", ":", "implications", "for", "viral", "latency", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0 ]

[ "TCR", "-contact", "site", "heterogeneity", "was", "excluded", "as", "the", "selective", "force", "in", "diversity", "generation", "since", "the", "epitope-encoded", "sequences", "were", "found", "to", "be", "identical", "within", "endogenous", "virus", "isolates", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Intratracheal", "instillation", "of", "IL-6", "alone", "into", "normal", "rats", "resulted", "in", "PMN", "infiltration", "into", "lung", "interstitium", "and", "alveoli", ",", "marked", "elevation", "of", "bronchoalveolar", "lavage", "cellularity", ",", "and", "increased", "wet-to-dry", "ratio", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "All", "cases", "had", "a", "remarkably", "poor", "prognosis", ",", "with", "a", "mean", "survival", "of", "9.6", "+/-", "6.6", "months", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "have", "shown", "that", "the", "c-Maf", "and", "c-Myb", "transcription", "factors", "physically", "interact", "in", "myeloid", "cells", "to", "form", "inhibitory", "complexes", "that", "hinder", "transactivation", "of", "c-Myb", "target", "genes", "through", "direct", "binding", "to", "Myb", "consensus", "sites", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 2, 0 ]

[ "Furthermore", ",", "while", "ligand-activated", "c-erbA/TR", "accelerated", "differentiation", ",", "unliganded", "c-erbA/TR", "effectively", "blocked", "differentiation", "and", "supported", "sustained", "progenitor", "growth", "in", "culture", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "therefore", "propose", "that", "such", "cross-talking", "among", "distinct", "adhesion", "molecules", "may", "be", "involved", "in", "the", "pathogenesis", "of", "inflammation", ",", "including", "RA", "synovitis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "One", "of", "the", "isolated", "genes", ",", "that", "for", "retinaldehyde", "dehydrogenase", "2", "(", "RALDH2", ")", ",", "was", "regularly", "expressed", "in", "most", "of", "the", "T-ALL", "cell", "lines", "that", "coexpressed", "TAL1", "and", "LMO", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 9, 0, 9, 0 ]

[ "Gel", "mobility", "shift", "assays", "demonstrated", "that", "specific", "DNA-protein", "complexes", "can", "be", "formed", "with", "each", "element", ",", "and", "that", "there", "are", "cell-specific", "differences", "in", "factors", ",", "which", "bind", "to", "the", "SP-1-like", "element", "between", "MEL", "and", "NIH3T3", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 5, 6, 6, 6, 0 ]

[ "The", "mycotoxins", "alpha-zearalenol", "and", "zearalenone", "both", "exhibited", "full", "agonist", "activity", ",", "but", "at", "lower", "potencies", ",", "with", "EC50", "values", "of", "1.8", "and", "54", "nM", ",", "respectively", ",", "compared", "with", "E2", "at", "0.5", "nM", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "elderly", "healthy", "subjects", ",", "Type", "II", "receptors", "were", "also", "significantly", "decreased", "(", "from", "1796", "+/-", "671", "to", "720", "+/-", "345", ")", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Regulation", "of", "jun", "and", "fos", "gene", "expression", "in", "human", "monocytes", "by", "the", "macrophage", "colony-stimulating", "factor", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 9, 10, 10, 0 ]