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A 4-year-old girl presents with persistent fever for the past week. The parents report a spike at 104F. The parents brought the child to the emergency room when they noticed erythematous rash on the girl's trunk. Physical examination reveals strawberry red tongue, red and cracked lips, and swollen red hands. The whites of both eyes are red with no discharge. | eligible ages (years): 13.0-999.0, Tonsillitis Pharyngitis Age equal to or over 13 years For female subjects, the following conditions are to be met Subject is premenarchal or surgically incapable of bearing children Subject is of childbearing potential and all of the following conditions are met Have normal menstrual flow within 1 month before study entry Have negative pregnancy test (urine pregnancy test sensitive to at least 50 mU/mL, and Must agree to use an accepted method of contraception throughout the study (if sexually active) Clinical diagnosis of acute tonsillitis/pharyngitis caused by Streptococcus pyogenes based on A positive result from a rapid detection test for Group A streptococcal antigen and submission of a throat swab specimen for bacterial culture, identification, and antibiotic-susceptibility testing; and A sore and scratchy throat and/or pain on swallowing (odynophagia) together with at least 2 of the following clinical signs Symptoms that collectively suggest nonstreptococcal T/P (eg, laryngitis, coryza, conjunctivitis, diarrhea, cough) History of positive throat culture for Streptococcus pyogenes in the absence of clinical signs and symptoms of T/P Infection of the deep tissues of the upper respiratory tract (eg, epiglottitis, retropharyngeal or buccal cellulitis, or abscess of the retropharynx, tonsil, or peritonsillar area) or of the suprapharyngeal respiratory tract and its connecting structures (eg, sinusitis, otitis media, or orbital/periorbital cellulitis) History of rheumatic heart disease Known congenital prolonged QT syndrome Known or suspected uncorrected hypokalemia (≤3 mmol/L [mEq/L) or hypomagnesemia or bradycardia (<50 bpm) Known impaired renal function, as shown by creatinine clearance ≤25 mL/min Myasthenia gravis History of hypersensitivity or intolerance to macrolides, penicillins, or cephalosporins Previous enrollment in this study or previous treatment with telithromycin | 0 |
A 4-year-old girl presents with persistent fever for the past week. The parents report a spike at 104F. The parents brought the child to the emergency room when they noticed erythematous rash on the girl's trunk. Physical examination reveals strawberry red tongue, red and cracked lips, and swollen red hands. The whites of both eyes are red with no discharge. | eligible ages (years): 3.0-999.0, Pharyngitis Streptococcus Pyogenes Infection Streptococcus Pyogenes Identification sore throat at least two Centor fever > 38 deg C or history of fever enlarged cervical lymph nodes tonsillar exudate lack of cough age 3-14 years antibiotic treatment in preceding 7 days no informed consent | 0 |
A 4-year-old girl presents with persistent fever for the past week. The parents report a spike at 104F. The parents brought the child to the emergency room when they noticed erythematous rash on the girl's trunk. Physical examination reveals strawberry red tongue, red and cracked lips, and swollen red hands. The whites of both eyes are red with no discharge. | eligible ages (years): 2.0-11.0, Dengue Virus Dengue Fever Dengue Hemorrhagic Fever Dengue Diseases Aged 2 to 11 years on the day of inclusion Subject in good health, based on medical history, physical examination and laboratory parameters Provision of Assent Form signed by the subject (for subjects ≥8 years old) and Informed Consent Form signed by the parents or another legally acceptable representative (and by an independent witness for illiterate parent[s]) Subject and parents/legally acceptable representative able to attend all scheduled visits and to comply with all trial procedures For a female subject of child-bearing potential (girls post-menarche), avoid becoming pregnant (use of an effective method of contraception or abstinence) for at least 4 weeks prior to first vaccination, until at least 4 weeks after the last vaccination Documented receipt of yellow fever vaccine since at least one month before the first vaccination Personal or family history of thymic pathology (thymoma), thymectomy, or myasthenia For a female subject of child-bearing potential (girls post-menarche), known pregnancy For a female subject of child-bearing potential (girls post-menarche), known pregnancy or positive pregnancy test in blood sample taken at Screening Participation in another clinical trial investigating a vaccine, drug, medical device, or a medical procedure in the 4 weeks preceding the first trial vaccination Planned participation in another clinical trial during the trial Known or suspected congenital or acquired immunodeficiency, immunosuppressive therapy such as anti-cancer chemotherapy or radiation therapy within the preceding 6 months, or long-term systemic corticosteroids therapy Known systemic hypersensitivity to any of the vaccines components or history of a life-threatening reaction to the trial vaccines or to a vaccine containing any of the same substances Systemic hypersensitivity to YF vaccine or history of a life-threatening reaction to YF vaccine Chronic illness at a stage that could interfere with trial conduct or completion, in the opinion of the Investigator Current or past alcohol abuse or drug addiction that may interfere with the subject's ability to comply with trial procedures | 0 |
A 4-year-old girl presents with persistent fever for the past week. The parents report a spike at 104F. The parents brought the child to the emergency room when they noticed erythematous rash on the girl's trunk. Physical examination reveals strawberry red tongue, red and cracked lips, and swollen red hands. The whites of both eyes are red with no discharge. | eligible ages (years): 16.0-999.0, Bacteremia lip/tongue piercing for at least six month in situ pregnancy and lactating women medication with known effects on gingival tissues antibiotic medication in the last six months or need for antibiotic prophylaxis chlorhexidine use in the last six months non-plaque induced gingival disease prior diagnosis of periodontitis | 0 |
A 4-year-old girl presents with persistent fever for the past week. The parents report a spike at 104F. The parents brought the child to the emergency room when they noticed erythematous rash on the girl's trunk. Physical examination reveals strawberry red tongue, red and cracked lips, and swollen red hands. The whites of both eyes are red with no discharge. | eligible ages (years): 2.0-999.0, Atopic Dermatitis Secondary Infection Female subjects of childbearing potential must have a negative urine pregnancy test at Baseline and practice a reliable method of contraception Secondary infection of atopic dermatitis with S.aureus or S.pyogenes as the probable causative agent An infected area less than or equal to 100 centimeters squared for subjects 18 years of age or older, or, 2% body surface area for subjects under 18 years of age Skin Infection Rating Scale score greater than or equal to 8 Able to understand and comply with the requirements of the study and sign Informed Consent/Health Insurance Portability and Accountability Authorization Forms. Subjects under the legal age of consent must also have the written informed consent of parent or legal guardian Female subjects who are pregnant, trying to get pregnant, breast feeding or who are of childbearing potential and not practicing reliable birth control Allergic to any component of the test medication Clinical diagnosis of impetigo, folliculitis or minor soft tissue infection Use of topical antibacterial medication to the study treatment area within 1 day of Visit 1 Signs of systemic infection or evidence of abcess or cellulitis at the site to be treated Medical condition that,in the opinion of the investigator, contraindicates the subject's participation in the clinical study Recent alcohol or drug abuse is evident History of poor cooperation, non-compliance with medical treatment or unreliability Participation in an investigational drug study within 30 days of Baseline Visit | 0 |
A 4-year-old girl presents with persistent fever for the past week. The parents report a spike at 104F. The parents brought the child to the emergency room when they noticed erythematous rash on the girl's trunk. Physical examination reveals strawberry red tongue, red and cracked lips, and swollen red hands. The whites of both eyes are red with no discharge. | eligible ages (years): 1.0-14.0, Hand, Foot and Mouth Disease Clinical diagnosis of severe hand-foot-mouth disease patients according to Hand-Foot-Mouth Disease Treatment Guidelines 2010 issued by China's Ministry of Health; More than 1/3 patients should be diagnosed by etiological examination Less than 48 hours of occurrence of fever and/or occurrence of tetter or herpes Age of 1-14 years Patients or their guardians agree to participate in this study and signed the informed consent form Complicated with other serious primary diseases in organ such as congenital heart disease, chronic hepatitis, nephritis and blood diseases, etc With history of allergies on traditional Chinese medicine Patients or their guardians suffering from Psychiatric diseases Attending other clinical studies on HFMD after diagnosed | 0 |
A 4-year-old girl presents with persistent fever for the past week. The parents report a spike at 104F. The parents brought the child to the emergency room when they noticed erythematous rash on the girl's trunk. Physical examination reveals strawberry red tongue, red and cracked lips, and swollen red hands. The whites of both eyes are red with no discharge. | eligible ages (years): 4.0-13.0, Obsessive-Complusive Disorder Children Anxiety Disorder Autoimmune Disease PANDAS Male and female children 4-13 years of age Presence of (Diagnostic and Statistical Manual of Mental Disorders Fourth Edition, Text Revision) DSM-IV TR OCD with or without a tic disorder Moderate or greater severity of symptoms, with a score of greater than or equal to 20 on the Children s Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) and greater than or equal to 4 on the Clinical Global Impression Severity scale (CGI-S) The acute onset within the previous six months of symptoms in a child previously well, or the first acute recurrence within the previous six months, after a period of relatively complete remission of symptoms. The acuity of symptom onset/exacerbation is key and must be severe, dramatic in onset, and proceed from no/minimal symptoms to maximum severity within 24-48 hours Symptom onset or first exacerbation preceded within four months by a GAS infection, as documented by positive throat culture, exposure to documented GAS infection (in a close contact, such as a sibling sharing a bedroom), and/or documented two-fold rise in one or more anti-GAS antibody titers such as anti-streptolysin O, anti-streptococcal DNAaseB, anti-carbohydrate antibodies and others Onset/exacerbation of OCD is accompanied by at least three of the following 7 clinical signs and symptoms. The acuity of the comorbid symptoms must be similar to the OCD symptoms and occur in the same time interval Markedly increased level of anxiety, particularly new onset of separation anxiety Emotional lability, irritability, aggressive behavior and/or personality change Sudden difficulties with concentration or learning Developmental regression ("baby-talk," temper tantrums; behaviors atypical for actual chronological age) History of rheumatic fever, including Sydenham chorea (the neurologic manifestation) Presence of symptoms consistent with autism, schizophrenia, or other psychotic disorder (unless psychotic symptoms have onset coincident with the possible and are attributed to OCD) Presence of a neurological disorder other than a tic disorder IQ < 70. Child subjects need to be able to contribute meaningfully to baseline and follow-up ratings, to report adverse effects, and to assent to participation Presence of serious or unstable medical illness or psychiatric or behavioral symptoms that would make participation unsafe or study procedures too difficult to tolerate IgA deficiency (< 20mg/dL). Intravenous immunoglobulin may contain trace IgA, which may very rarely lead to life-threatening anaphylaxis in IgA-deficient participants with anti-IgA antibodies (Misbah 1993) Hyperviscosity syndromes, which can increase risks associated with IVIG administration Need for live virus vaccine within six months after receiving IVIG (which may be 7.5 months from randomization) since IVIG can interfere with effectiveness of such vaccines. IVIG should not be administered sooner than two weeks after administration of a live virus vaccine, for the same reason Taking nephrotoxic drugs. Every concomitant medication will be subject to scrutiny and possible consultation with pediatric safety monitors before randomization to study drug. See below as well Recent (less than eight weeks) initiation of cognitive-behavior therapy (CBT) | 0 |
A 4-year-old girl presents with persistent fever for the past week. The parents report a spike at 104F. The parents brought the child to the emergency room when they noticed erythematous rash on the girl's trunk. Physical examination reveals strawberry red tongue, red and cracked lips, and swollen red hands. The whites of both eyes are red with no discharge. | eligible ages (years): 18.0-70.0, Oral Health Oral Cancer Gum Disease Submit to a 24 hour urine cotinine test which will be used to determine smoking status Meet one of the following smoking Non-smoker Does not currently smoke or has no history of smoking or using tobacco related products (cigarettes, cigars, pipe, snuff, or chewing tobacco) or smoking any non-tobacco related products and urine cotinine (less than 100 ng/mL Does not currently smoke but has quit smoking for more than 10 years and smoked less than 1 pack/day of cigarettes when they were actively smoking and has a urine cotinine (less than 100 ng/mL) Smoker Smokes habitually at least 10 cigarettes/day and a urine cotinine level of >1000 ng/mL. Cigar and pipe smokers who smoke at least 10 grams of tobacco daily are also eligible Agree to consume a standardized vitamin and mineral supplement and avoid other nutritional, dietary, or alternative medications/supplements for the duration of the study No history of malabsorptive, gastrointestinal or other metabolic disorders requiring special diet recommendations Body mass index (BMI) between 20 and 35 kg/m2 Have a known allergy to strawberries, corn, and wheat products or those who have never consumed any of these products Have active metabolic or digestive illnesses such as malabsorptive disorders (Crohn's, ileus, IBS), renal insufficiency, hepatic insufficiency, hyper or hypothyroidism, cachexia, morbid obesity, or short bowel syndrome Have a history of pituitary hormone diseases that currently require supplemental hormonal administration (thyroid hormones, ACTH, growth hormone, insulin) or other endocrine disorders requiring hormone administration Have significant loss of gastrointestinal organs due to surgery, except for appendix Have altered immunity such as chronic inflammatory disease, autoimmune disorders, cancer, anemia, hemophilia, and blood dyscrasias Heavy alcohol consumers defined as >15 glasses/week (one glass = 1.5 oz. liquor, 5 oz. wine, or 12 oz. beer) Antibiotic use in the last 6 months or on medications that will accelerate or decrease bowel motility Are receiving or in need of dental treatment during the study period Have noticeable open lesions, sores that have not healed for more than 3 months, have had any active oral lesions or maladies within the last month, or have a history of leukoplakia, tumors of the buccal cavity, throat, and lips | 0 |
A 4-year-old girl presents with persistent fever for the past week. The parents report a spike at 104F. The parents brought the child to the emergency room when they noticed erythematous rash on the girl's trunk. Physical examination reveals strawberry red tongue, red and cracked lips, and swollen red hands. The whites of both eyes are red with no discharge. | eligible ages (years): 0.083-15.0, Invasive GAS Infection Age ≥ 1 month to <15 years at the time of Group 1 : Children hospitalized for invasive GAS infection Subgroup 1A ( N = 75 ): Children with invasive infection without known risk factor Subgroup 1B (N = 75) : Children with invasive infection with known risk factor GAS Invasive infections are defined by a) Proved infection : Bacteriological isolation of S. pyogenes from a liquid or a normally sterile site, except from a blister of a simple erysipelas, without necrosis . This is sometimes associated with a shock with multiorgan failure (streptococcal toxic shock syndrome ( STSS )) b ) Probable infection . Bacteriological isolation of S. pyogenes from a normally non-sterile site ( eg skin, upper respiratory tract ) associated with extensive soft tissue necrosis . Bacteriological isolation of S. pyogenes a site or a biological sample usually non-sterile ( eg skin , upper respiratory tract ) associated with a evocative shock syndrome STSS and no other cause found Contributing factors for invasive infection are defined by cutaneous effraction (wounds , burn , chicken pox ), the use of corticosteroids or other treatment, immunosuppressive and recent surgery Group 1: Children with a known immune deficiency unrelated to the risk factors described above Group 2: Children with a known immune deficiency | 1 |
A 4-year-old girl presents with persistent fever for the past week. The parents report a spike at 104F. The parents brought the child to the emergency room when they noticed erythematous rash on the girl's trunk. Physical examination reveals strawberry red tongue, red and cracked lips, and swollen red hands. The whites of both eyes are red with no discharge. | eligible ages (years): 10.0-999.0, Kawasaki Disease Aneurysm, Coronary Clinical diagnosis of Kawasaki Disease with giant aneurysm Must be older than 10 years old Subjects ever received coronary artery bypass graft (CABG) surgery Subjects have active hepatitis or persistent abnormal liver function such as elevated GOT and GPT Subjects have the past history of rhabdomyolysis Female subjects are pregnant or plan for child-bearing during study periods | 0 |
A 4-year-old girl presents with persistent fever for the past week. The parents report a spike at 104F. The parents brought the child to the emergency room when they noticed erythematous rash on the girl's trunk. Physical examination reveals strawberry red tongue, red and cracked lips, and swollen red hands. The whites of both eyes are red with no discharge. | eligible ages (years): 0.0-999.0, Kawasaki Disease (both 1 and 2) All subjects are children who fulfilled the for Kawasaki Disease (American Heart Association criteria) Fever > 5 days, and 4 of the 5 following symptoms Diffuse mucosal inflammation (strawberry tongue, dry and fissured lips) Bilateral non-purulent conjunctivitis Dysmorphous skin rashes Indurative angioedema over the hands and feet Cervical lymphadenopathy. (One or more nodule at lease 1.5 cm in diameter) 2. KD patients are treated with IVIG at each hospital after informed contents are obtained Patients whose symptoms did not full fit the Kawasaki Disease criteria Had an acute fever for < 5 days and >10 days Incomplete collection of each followed-up data (CBC/DC, GOT/GPT, BUN/Cr, Albumin, ESR, C-Reactive Protein, 2D echocardiography) IVIG treatment at other hospital before refers to study centers Treatment with corticosteroids, other than inhaled forms, in the previous 2 weeks before enrollment The presence of a disease known to mimic Kawasaki disease Previous diagnosis of Kawasaki disease Inability to take aspirin | 2 |
A 4-year-old girl presents with persistent fever for the past week. The parents report a spike at 104F. The parents brought the child to the emergency room when they noticed erythematous rash on the girl's trunk. Physical examination reveals strawberry red tongue, red and cracked lips, and swollen red hands. The whites of both eyes are red with no discharge. | eligible ages (years): 18.0-999.0, Cirrhosis Coagulopathy Patients 18 and older, admitted to the hospital Patients who have clinically documented cirrhosis Patients who are coagulopathic (INR > 1.5 and/or platelets < 50,000) Patients undergoing an endoscopic procedure or neurosurgical procedure Patients must not be pregnant Patients must not be taking any anticoagulant or antiplatelet medication (with the exception of ASA 81 mg or heparin for DVT prophylaxis) Patients must not have an active infection (per PI discretion) Patients must not have any known hemostatic disorder | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 50.0-80.0, Osteoporosis 80 years of age, inclusive years since last menses Dx femoral neck osteoporosis No vertebral fractures Poor candidate for study drugs Hx of diseases affecting bone metabolism Hx of breast/estrogen-dependent cancer Current use of osteoporosis drug therapy Hx/high risk of VTE | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Small Cell Lung Cancer Written informed consent (patient's written understanding of and agreement to participate in this study) Patients with confirmed extensive small cell lung cancer (SCLC) No prior chemotherapy within 5 years of the diagnosis of SCLC Presence of either measurable or non-measurable SCLC by X-ray or physical examination At least 3 weeks since last major surgery (a lesser period is acceptable if decided to be in the best interest of the patient) At least 24 hours since prior radiotherapy. Patients who have received radiotherapy must have recovered from any reversible side effects, such as nausea and vomiting Laboratory Patients must have adequate bone marrow reserve and adequate kidney and liver function Symptoms of spreading of the disease to the brain that requires treatment with drugs called steroids Any active infection Severe medical problems other than the diagnosis of SCLC, that would limit the ability of the patient to follow study guidelines or that would expose the patient to extreme risk Ongoing or planned chemotherapy, immunotherapy, radiotherapy, or investigational therapy for the treatment of SCLC Use of an investigational drug within 30 days before the first dose of study medication Women who are pregnant or lactating Patients of child-bearing potential who refuse to practice an adequate form of birth control Patients with clinical evidence of any stomach or intestinal (GI) condition Patients requiring treatment with the drug cyclosporin A | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Sepsis Adult patients with severe sepsis Presence of a suspected or proven infection One or more sepsis-associated organ failure Are indicated for the treatment with drotrecogin alfa (activated) in the investigative site country Are contraindicated for treatment with drotrecogin alfa (activated) under the applicable label in the investigative site country Platelet count <30,000/mm3 Are receiving therapeutic heparin | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 10.0-50.0, Pneumothorax All patients requiring VATS caused by recurrent, persistent, or contralateral spontaneous pneumothorax as well as by spontaneous hemopneumothorax were eligible for this study greater than 50 years of age, with underlying pulmonary disease, previous ipsilateral thoracic operation, allergy to tetracycline or minocycline, and unwilling to receive randomization | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Critical Illness Deep Venous Thrombosis Patient is >/= 18 years of age Actual body weight is >/= 45 kg Admission to ICU expected to be >/= 72 hours in duration Neurosurgery within last 3 months Ischemic stroke within last 3 months Intracranial hemorrhage within last 3 months Systolic Blood Pressure >/= 180mm Hg, Diastolic Blood Pressure >/= 110mm Hg for >/= 12 hours requiring vasoactive drug infusion Major hemorrhage within last week unless definitively treated Coagulopathy as defined by INR >/= 2 times upper limit of normal [ULN], or PTT >/= 2 times ULN, at time of screening Thrombocytopenia defined as platelet count </= 75 x 109/L, at time of screening Other heparin contraindications (e.g., HIT, pregnancy, lactating) Contraindication to blood products (e.g., Jehovah's Witness) Unable to perform lower limb ultrasound (e.g., bilateral above the knee amputation, or severe distal extremity burns) | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Critically Ill Deep Venous Thrombosis Admission to ICU Men and women greater than 18 years of age or older Expected to remain in ICU admission greater than 72 hours Contraindications to LMWH or blood products Trauma, post orthopedic surgery, post cardiac surgery or post neurosurgery patients Uncontrolled hypertension as defined by a systolic blood pressure > 180 mmHg or a diastolic blood pressure > 110 mmHg Hemorrhagic stroke, DVT, PE or major hemorrhage on admission or within 3 months Coagulopathy as defined by INR >2 times upper limit of normal [ULN], or PTT >2 times ULN Renal insufficiency as defined by a creatinine clearance <30ml/min A need for oral or intravenous or subcutaneous therapeutic anticoagulation Heparin allergy, proven or suspected heparin-induced thrombocytopenia (HIT) Receipt of >2 doses of UFH or LMWH in ICU Pregnant or lactating | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 16.0-999.0, Deep Vein Thrombosis Pulmonary Embolism Age > 16 years Unilateral or bilateral, closed or open, fractures of the lower extremity distal to the knee including Isolated fractures of the tibia including tibial plateau, shaft and plafond and medial malleolus Isolated fractures of the fibula including fibular head, fibular diaphysis,distal fibula and lateral malleolus Combined fractures of the tibia and fibula Tibia and/or fibula fractures may be accompanied by fractures of the patella and/or foot as well as ligamentous injuries as long as either the tibia or the fibula is involved Patients must be scheduled to undergo surgery (internal or external fixation) for repair of their fracture during the current admission Patients presenting greater than 72 hours after injury Major injury involving other site(s) Lower extremity vascular injury requiring surgical repair Known systemic bleeding disorder or INR > 1.5, aPTT > 40 sec, or platelets < 50 x 109/L at baseline Active, uncontrolled bleeding (as determined by the attending surgeon or delegate) Intracranial or other major bleed in the previous 4 weeks Ongoing need for anticoagulation for other reasons Previous DVT or PE (objectively proven or treated with anticoagulants) Known molecular hypercoagulable state Active cancer | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 0.0-999.0, Quality of Health Care Pulmonary Embolism patient with suspected pulmonary embolism prescription of a specific paraclinical diagnostic investigation or start of a specific treatment for pulmonary embolism confirmation or of pulmonary embolism before admission in emergency department confirmation of deep venous thrombosis before admission in emergency department suspicion of pulmonary embolism during hospitalization (in-patient) suspicion of pulmonary embolism without investigation realization patient already included in the study patient refusing the utilization of his data for the study | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 30.0-85.0, Total Hip Replacement Patients accepted for fast-track total hip replacement, i.e.ASA 3 or lower Not able to speak dutch communication problems dementia mental retardation | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Deep Vein Thrombosis (must meet 1, 2 and 3) At high risk for thromboembolism (any one of the following) Age > 35 years Obesity (> 80 kg) Para 4 Gross varicose veins Current infection Pre-eclampsia Immobility prior to surgery (> 4 days) Major current disease: includes heart or lung disease, cancer, inflammatory bowel disease, and nephrotic syndrome (must not meet any of the following criteria) Greater than 36 hours since delivery Need for anticoagulation, including Women with a confirmed thrombophilia Women with paralysis of lower limbs Women with personal history of VTE Women with antiphospholipid antibody syndrome (APLA) Women with mechanical heart valves Contraindication to heparin therapy, including History of heparin induced thrombocytopenia | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Diabetes Diabetes Mellitus, Type 2 Diagnosis of type 2 diabetes HbA1C <= 12.0% within the past 12 months BMI <= 45.0 kg/m2 Initiation, addition of, change to, or continuation of basal insulin therapy with insulin detemir as deemed necessary by Investigator Anticipated change in concomitant medication known to interfere with glucose metabolism such as systemic steroids, non-selective beta-blockers or mono amine oxidase (MAO) inhibitors Proliferative retinopathy or maculopathy that has required acute treatment within the last 6 months Any glucose lowering medication that is not indicated in combination with insulin, such as GLP-1 Analogues Known hypoglycemia unawareness or recurrent major hypoglycemia, as judged by the Investigator | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Right Heart Strain Referred from clinical departments at Odense University Hospital Referred to the Departments of Nuclear Medicine or Radiology for diagnostic evaluation of suspected pulmonary embolism Referred for lung scintigraphy, spiral computer tomography, or pulmonary angiography Age below 18 Contrast allergy Pregnancy S-Creatinine above 200 micromol/L Metformin treatment Fibrinolytic or surgical therapy between examinations No informed consent Withdrawn consent Failed logistics (more than 24 hours between examinations) No conclusive pulmonary angiography | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 40.0-999.0, Embolism Hospitalization due to an acute non-surgical disease Significant decrease in mobility Indication for anticoagulant or thrombolytic therapy Major surgical or invasive procedure within the 4 weeks that precede randomization Expected major surgical or invasive procedure (including spinal/peridural/epidural anesthesia or lumbar puncture) within the 2 weeks that follow the randomization Immobilization due to cast or fracture of lower extremity Immobilization lasting longer than 3 days in the period prior to randomization Heparin administration longer than 36 hours in the period prior to randomization Acute ischemic stroke Other protocol-defined inclusion/ | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 16.0-999.0, Adult Respiratory Distress Syndrome Pulmonary Hypertension After obtaining informed consent the following patients will be included All patients admitted to the ICU with pulmonary hypertension (mean PA > 35 mmHg) All patients in ICU with post operative pulmonary HTN (mean PA > 35 mm Hg) All patients with ARDS (PaO2/FiO2 < 200 arterial hypoxemia, bilateral infiltrates on Chest X-ray infiltrates on CXR and a wedge < 20 mm Hg on swan ganz parameters) or signs of heart failure Patients to be excluded will be those with Pulmonary embolus Cor pulmonale Ejection fraction of < 30%, wedge > 20 mm Hg Non-intubated patients Pediatric patients (< 16 yrs of age) | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Deep Vein Thrombosis of Lower Limb Pulmonary Embolism (PE) Bleeding Adult patient (Age >18). Patient intended to undergo elective primary unilateral THA surgery. Patient is able and willing to follow instructions of care after surgery. Patient is able and willing to sign the institution human subjects committee approved Informed Consent Form Patient who has a known coagulation disorder. Patient currently treated with anticoagulant medications. Patient with known thrombophilia Patient with current signs and symptoms of or history of DVT/PE. Patient who is uncooperative or unable to follow instructions. Patient currently suffering from a solid tumor malignancy. Patient with active peptic disease. Patient with known allergy to baby aspirin (81 mg) or enoxaparin. Patient with contraindication to use of the device including patients with leg gangrene, recent skin graft or medical situations where increase venous and lymphatic return is undesirable.Patient has major surgery procedure within 3 months prior to the study surgery, or patients with a major surgery procedure planning during the study period.Pregnant women.Patient who is participating in another clinical drug trial | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 40.0-80.0, Chronic Obstructive Pulmonary Disease Established clinical history of moderate to severe COPD Post bronchodilator FEV1 of < 50% of predicted normal FEV1 / FVC ratio <70% Reversibility to 400mcg albuterol of less or equal to 10 predicted at Visit 1 Free from exacerbation in the 6 weeks prior to screening Current or former smoker with a smoking history of = 10 pack-years and has a history of COPD exacerbations Current asthma, eczema, atopic dermatitis and/or allergic rhinitis Has a known respiratory disorder other than COPD (e.g. lung cancer, sarcoidosis, tuberculosis or lung fibrosis) Has narrow-angle glaucoma, prostatic hyperplasia or obstruction of the neck of the bladder that in the opinion of the investigator should prevent the subject from entering the study Has undergone lung transplantation and/or lung volume reduction Female who is a nursing mother Requires regular (daily) long-term oxygen therapy (LTOT) Is receiving beta-blockers (except eye drops) Has a serious, uncontrolled disease likely to interfere with the study Has received any other investigational drugs within the 4 weeks prior to Visit 1 Has, in the opinion of the investigator, evidence of alcohol, drug or solvent abuse | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Patients enrolled into the trial must meet all of the following At least 18 years of age and able to provide informed consent Objectively confirmed symptomatic APE [intraluminal filling defect on spiral computed tomography (CT) or pulmonary angiography, or high probability ventilation-perfusion (V/Q)lung scan Stable and low risk defined as Hemodynamically stable (HR≤120, no hypotension, no tachypnea, no mental status change, no shock state) O2 supplement ≤4 L/NC Lack of electrocardiographic or echocardiographic evidence for new RV strain Radiographically non-massive PE (absence of saddle emboli on PA gram or spiral CT, perfusion defect on V/Q scan <50% No significant cardiac abnormalities (EF<35%, unstable angina, positive stress test within the past 3 months without revascularization) or pulmonary disease (severe COPD, pulmonary HTN) Patients meeting one or more of the following are not eligible for enrollment into the trial In the opinion of the clinician, the patient should receive in-patient standard medical therapy Contraindication for anticoagulation therapy (active or recent bleeding, recent surgery, bleeding diathesis, recent neurologic event) Is receiving therapeutic doses of UFH or LMWH for >24 hours Thrombolytic or glycoprotein IIb/IIIa agents administered within 24 hours prior to enrollment Platelet count <100,000 Creatinine clearance <30 mL/min at time of enrollment Presence of neuraxial anesthesia and/or post-operative indwelling epidural catheter Known history of antiphospholipid antibody syndrome Weight >150 kg (330.7 lbs) or <45 kg (99.2 lbs) | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Deep Vein Thrombosis Pulmonary Embolism Symptomatic acute deep venous thrombosis and/or pulmonary embolism confirmed by venous ultrasound and/or CT scan Pulmonary embolism patients with normal right ventricular size on chest CT scan Age greater than 18 years Anticipated discharge within 72 hours of admission Written informed consent Pregnancy or intend to become pregnant Patients requiring ongoing hospitalization > 72 hours Hypersensitivity to heparin, pork products or enoxaparin Creatinine > 2.0 mg/dl Recurrent DVT and/or PE with oral anticoagulation Surgery or medical procedure planned during the study that may pose a significant bleeding risk Prior history of heparin-induced thrombocytopenia Inability to participate for follow up appointments and study visits Life expectancy < 30 days High risk of bleeding | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Deep Vein Thrombosis Pulmonary Embolism Recurrent venous thromboembolism despite anticoagulation with warfarin(Or) Clinically important bleeding complications due to warfarin(Or) Inability to achieve the target INR on warfarin(Or) Nonbleeding side effects of warfarin, such as hair loss, rash, purple toe syndrome(Or) Patient with cancer on monotherapy with parenteral anticoagulation for DVT and/ or PE and Require at least 90 days of anticoagulation Require anticoagulation for objectively confirmed DVT and/or PE Age greater than 18 years Written informed consent Patients with renal insufficiency, defined as creatinine > 1.5 mg/dl Patients in whom anticoagulation with any agent is deemed unsafe due to bleeding risk Pregnancy Known hypersensitivity to fondaparinux | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Distal (Calf) Deep-vein Thrombosis All outpatients with an acute, symptomatic, distal DVT will be included in the study, provided they correspond to the following diagnostic and and they have signed an informed consent form Age less than 18 years Previously objectively diagnosed DVT or PE Distal DVT involving the tibioperoneal trunk (i.e. calf trifurcation) Clinically suspected pulmonary embolism Active cancer, receiving cancer treatment or cancer considered cured for <6 months Ipsilateral or contralateral proximal DVT Indication for long-term anticoagulation (e.g. atrial fibrillation, mechanical heart valve...) Pregnancy Thrombocytopenia (platelet count < 100 g/l) | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pulmonary Embolism age >18 years objectively confirmed diagnosis of pulmonary embolism patients at low-risk (Pulmonary Embolism Severity Index score <=85) patients at high-risk (Pulmonary Embolism Severity Index score >85) presence of hypoxemia (arterial SO2 <90% measured by pulse oximetry or an paO2 on room air of <60 mm Hg measured by blood gas analysis) systolic blood pressure of <100 mm Hg chest pain necessitating parenteral opioid administration active bleeding or at high-risk of major bleeding (stroke during the preceding 10 days, gastrointestinal bleeding during the preceding 14 days, or platelets <75,000 per mm3) renal failure (creatinine clearance of <30 ml/minute based on the Cockcroft-Gault formula) body mass >150 kg history of HIT or allergy to heparins therapeutic oral anticoagulation (INR ≥2)at the time of pulmonary embolism diagnosis potential barriers to treatment adherence or follow-up (alcoholism, illicit current or recent drug use, psychosis, dementia, homelessness, lack of telephone access, transportation time to nearest ED >45 minutes) | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 70.0-999.0, Thromboembolism Hospitalized medical patients 70 years of age or older Acute medical illness with significant decrease in mobility expected for at least 4 days (patient bedridden or only able to walk short distances) written informed consent immobilization longer than 3 days prior to randomization prior major surgery, trauma or invasive procedure within the last 4 weeks including any injuries or operation of central nervous system expected major surgical or invasive procedure within the next 3 weeks after randomization LMWH/heparin administration longer than 48 hours in the 5 days prior to randomization immobilization due to cast or fracture indication for anticoagulatory or thrombolytic therapy acute symptomatic DVT / PE known hypersensitivity to any of the study drugs or drugs with similar chemical structures Acute or history of heparin induced thrombocytopenia type II (HIT II) Other protocol-defined inclusion/ | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-75.0, Musculoskeletal Chest Pain Non-cardiac Chest Pain Undiagnosed Chest Pain To be included in the project the participant must Have chest pain as their primary complaint Have an acute episode of pain of less than 7 days duration before admission Consent to the standardized evaluation program at the chest pain clinic Have pain the in the thorax and/or neck Be able to read and understand Danish. Be between 18 and 75 year of age Be a resident of the Funen County Patients will not be included if any of the following conditions are present ACS Have had Percutaneous Coronary Intervention (PCI) or Coronary Artery By-pass Grafting (CABG) Participants will be excluded following baseline evaluation if any of the following conditions are present Pain not related to the joints and muscles of the neck and/or thorax (CTA negative, see below) New incidence of any of the above mentioned conditions/pathologies | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Hypertension Obesity patients with essential hypertension aged >/= 18 years with one of the following risk factors: history of coronary artery disease or stroke/TIA or peripheral artery disease or diabetes mellitus according to SPC | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Lung Cancer biopsy confirmed primary lung cancer undergoing radiotherapy or chemoradiotherapy able to perform adequate deep inspiration breath hold patients of childbearing potential must practice adequate contraception signed study-specific informed consent form unable to perform adequate deep inspiration breath hold prior tumor resection prior chest or neck RT pregnant | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-65.0, Cervical Degenerative Disc Disease Male or female subjects, aged between 18 and 65 years inclusive Subjects who are able to give voluntary, written informed consent to participate in this clinical investigation and from whom consent has been obtained Subjects who, in the opinion of the Clinical Investigator, are able to understand this clinical investigation, co-operate with the investigational procedures and are willing to return to the hospital for all the required post-operative follow-ups Objective evidence of cervical disc disease in one vertebral level between C3-C7 defined as one or more of the following Shoulder and/or arm pain in a radicular distribution resulting from herniated disc or bony osteophytes (Consistent w diagnostic imaging including Axial CT, CT Myelogram, MRI and/or plain films) Subjects with myeloradiculopathy resulting from mild spinal cord compression and nerve root impingement Unresponsive to documented non-surgical management for ≥ 6 weeks and/or presents with progressive symptoms of nerve root or spinal cord compression in the face of continued non-surgical management (e.g., physical therapy, medication therapy, corticosteroid injections, etc.) Minimum Neck Disability Index score of ≥30 % (15/50 points) Subjects who, in the opinion of the Clinical Investigator, have an existing condition that would compromise their participation and follow-up in this clinical investigation Subjects who are pregnant, lactating or wishes to become pregnant within the duration of the study Subjects who are known drug or alcohol abusers or with psychological disorders that could affect follow-up care or treatment outcomes Subjects who have participated in a clinical investigation with an investigational product in the last 30 days Subjects who are currently involved in any injury litigation claims Subjects with significant degeneration at more than one cervical level (e.g. DISH, ankylosing spondylitis, congenital abnormality, rheumatoid arthritis) Subjects who have had any prior surgery at the level to be treated (subjects with a prior Laminotomy at the level to be treated may be included in the study) Subjects who have marked cervical instability on lateral or flexion/extension x-rays defined as translation ≥3mm and/or ≥11 degrees of rotational difference to either adjacent level Subjects who have presence of systemic infection or infection at the site of surgery Subjects who have been diagnosed with malignancy | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Chronic Obstructive Pulmonary Disease Asthma Pulmonary Embolism Pneumonia Pulmonary Hypertension Presenting to the Emergency Department with signs and symptoms of dyspnea (short of breath, tachypnea, hyperventilation, etc) within the last 24 hours Normal cardiac output as measured by noninvasive bioimpedance Greater than or equal to 18 years of age Patient or legal representative willing and able to provide informed consent and comply with study procedures A history of congestive heart failure and a BNP > 500pg/mL (or NTproBNP > 900pg/mL) if obtained by the treating physician Treating physician suspects patient has new onset congestive heart failure ECG changes diagnostic of acute myocardial ischemia/infarction Ischemic chest pain within the prior 24 hours by history Obvious chest trauma | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-75.0, Deep Vein Thrombosis Pulmonary Embolism Be >= 18 years of age Have had ONE episode of unprovoked proximal DVT and/or PE Have completed 3 uninterrupted months of warfarin therapy (target INR of 2.0-3.0) Another indication for long-term anticoagulation (e.g., atrial fibrillation) A high risk of bleeding as evidenced by any of the following Age greater than 75 years Previous episode of major bleeding where the cause was not effectively treated Known chronic thrombocytopenia with a platelet count of less than 120,000 x 10^9 /L Known chronic renal impairment with a creatinine of more than 150 mumols /litre (1.7 mg/dl) Known chronic liver disease with a total bilirubin of more than 25 mumols /litre (1.5 mg/dl) Active peptic ulcer disease Poor compliance with, or control of, anticoagulant therapy during initial treatment Requires dual antiplatelet therapy (e.g. aspirin and clopidogrel) | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Patients with a first episode of idiopathic pulmonary embolism who have been treated during 6 months (Plus 30 days or minus 15 days) using Vitamin K antagonist with a INR between 2 and 3 Age < 18 warfarin hypersensibility unwilling or unable to give written informed consent distal or proximal deep vein thrombosis Pulmonary embolism which was provoked by a reversible major risk factor major thrombophilia (protein C, S or antithrombin deficiency, antiphospholipids antibodies, homozygous factor V Leiden) previous documented episode of proximal deep vein thrombosis or pulmonary embolism other indication for anticoagulant therapy (e.g.:atrial fibrillation, mechanic valve) patient on antithrombotic agent in whom antithrombotic agent should be started again after stopping anticoagulation pregnancy | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Chest Pain Ischemia Patient referred for elective coronary angiography because of a reasonable clinical suspicion of coronary ischemia Presence of angina or an anginal equivalent (including chest, back, shoulder, arm, neck, jaw discomfort, or shortness of breath brought on by physical exertion, emotional stress, or certain times of day/month) Asymptomatic (such as a pre-op cath) Status-post heart transplant Status-post coronary artery bypass grafting Age <18 Renal insufficiency (creatinine >1.5) Presence of an acute coronary syndrome (STEMI or Tako-tsubo, an abnormal ejection fraction (EF<55%), cardiogenic shock, or recent VT/VF Presence of another likely explanation of chest pain, such as pulmonary hypertension or aortic stenosis History of adverse reaction to any of the medications being used (acetylcholine, nitroglycerin, adenosine, or heparin) Currently taking vasoactive medication (such as nitroglycerin) Inability to provide an informed consent, including an inability to speak, read, or understand English, Spanish, Chinese, Farsi, Japanese, Korean, Russian, or Vietnamese | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 19.0-999.0, Chest Tube Removal Patients who are post thoracotomy, pulmonary resection (wedge, lobectomy, segmentectomy, pneumonectomy), AND Have at least one chest tube Less than 19 years old With interstitial lung disease, OR Any patient intubated | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 0.0-999.0, Dyspnea Heart Failure Asthma COPD patient had to present with shortness of breath as the primary complaint (defined as either the sudden onset of dyspnea without history of chronic dyspnea or an increase in the severity of chronic dyspnea) age <18 years history of renal insufficiency, trauma, severe coronary ischemia (unless patient's predominant presentation was dyspnea), and other causes of dyspnea pneumonia pulmonary embolism carcinoma pneumothorax pleural effusion intoxications (drugs) anaphylactic reactions upper airway obstruction | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Venous Thromboembolism Age > 18 years first episode of objectively documented symptomatic idiopathic VTE, either proximal lower extremity deep vein thrombosis (DVT) and/or pulmonary embolism (PE) Unprovoked or idiopathic , or associated with one or more of the following favouring factors minor general surgery, arthroscopy or laparoscopy pregnancy or puerperium hormonal treatment (contraceptive or replacement therapy) travel minor traumas hospitalization in a medical ward reduced mobility (non complete immobilization) at least six months of VKA therapy ( or other type) for at least 3 months and not longer than 12 months ability to provide informed consent Two or more episodes of objectively documented proximal DVT and or PE ( previous distal of superficial vein thrombosis are not Index event was isolate distal ( calf) vein thrombosis Index event was PE associated with shock or prolonged hypotension at high risk Index event was DVT in sites different from the lower limbs Pregnancy or puerperium ( first 6 weeks after delivery) at the time of the visit Solid or haematological malignancy in the active phase or undergoing chemotherapy or radiotherapy Antiphospholipid antibody syndrome, diagnosed according to the Sydney Hereditary antithrombin deficiency Necessity to prolong anticoagulation for any reason (due to the thrombotic event or other clinical indications Severe respiratory or heart failure (NYHA classes: III or IV) | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 21.0-80.0, Arthroplasty, Replacement, Knee The subject is a male or non-pregnant female 21-80 years of age at the time of enrollment The subject requires a primary cemented total knee replacement The subject has a diagnosis of osteoarthritis (OA), traumatic arthritis (TA), or avascular necrosis (AVN) The subject has intact collateral ligaments The subject has signed the IRB approved, study specific Informed Patient Consent Form The subject is willing and able to comply with postoperative scheduled clinical and radiographic evaluations and rehabilitation The subject has inflammatory arthritis The subject is morbidly obese, BMI > 40 The subject has a history of total or unicompartmental reconstruction of the affected joint The subject has had a high tibial osteotomy or femoral osteotomy The subject has a neuromuscular or neurosensory deficiency that would limit the ability to assess the performance of the device The subject has a systemic or metabolic disorder leading to progressive bone deterioration The subject is immunologically suppressed, or receiving chronic steroids (>30 days duration) The subject's bone stock is compromised by disease or infection and cannot provide adequate support and/or fixation to the prosthesis The subject has had a knee fusion at the affected joint The subject has an active or suspected latent infection in or about the knee joint | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Idiopathic Venous Thromboembolism First episode of major unprovoked VTE VTE objectively proven VTE treated for 5-12 months with anticoagulant therapy authorized for the II study (initial or ongoing therapy) Absence of recurrent VTE during the treatment period Less than 18 years of age Patients who have already discontinued anticoagulant therapy Patients requiring ongoing anticoagulation for reasons other than VTE Being treated for a recurrent unprovoked VTE Patients with high risk thrombophilia patients who plan on using exogenous estrogen(OCP,HRT)if anticoagulant therapy is discontinued Patients with pregnancy associated VTE Geographically inaccessible for follow-up Patients unable or unwilling to provide informed consent | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Acute Pulmonary Embolism acute (symptoms <24 hrs) with right ventricular dilatation (>30 mm end diastolic, systolic PAP > 50 mmHg absence of right ventricular wall hypertrophy) age below 18 years or above 70 years body mass index >35 kg/m2 duration of symptoms >24 hours (since onset or acute increase in symptoms) severe circulatory shock (systemic blood pressure systolic <80 mmHg, or diastolic blood pressure <45 mmHg) or respiratory failure, requiring mechanical ventilation patients who, in the opinion of the supervising physician, require thrombolytic therapy severe pre-existent cardiopulmonary disease (heart failure, obstructive pulmonary disease, emphysema) atrial fibrillation refusal or inability to give informed consent | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 40.0-75.0, Acute Coronary Syndrome Myocardial Infarction Unstable Angina Pectoris Participant had at least five minutes of chest pain or equivalent (chest tightness; pain radiating to left, right, or both arms or shoulders, back, neck, epigastrium, jaw/throat; or unexplained shortness of breath, syncope/presyncope, generalized weakness, nausea, or vomiting thought to be of cardiac origin) at rest or during exercise within 24 hours of ED presentation, warranting further risk stratification, as determined by an ED attending 2 or more cardiac risk factors (diabetes, hypertension, hyperlipidemia, current smoker and family history of coronary artery disease) Able to provide a written informed consent <75 years of age, but >40 years of age Able to hold breath for at least 10 seconds Sinus rhythm New diagnostic ischemic ECG changes (ST-segment elevation or depression > 1 mm or T-wave inversion > 4 mm) in more than two anatomically adjacent leads or left bundle branch block Documented or self-reported history of CAD (MI, percutaneous coronary interventions [PCIs], coronary artery bypass graft [CABG], known significant coronary stenosis [>50%]) Greater than 6 hours since presentation to ED BMI >40 kg/m2 Impaired renal function as defined by serum creatinine >1.5 mg/dL* Elevated troponin-T (> 0.09 ng/ml) Hemodynamically or clinically unstable condition (BP systolic < 80 mm Hg, atrial or ventricular arrhythmias, persistent chest pain despite adequate therapy) Known allergy to iodinated contrast agent Currently symptomatic asthma Documented or self-reported cocaine use within the past 48 hours (acute) | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 14.0-999.0, Lower Abdominal Pain Right Iliac Fossa Pain Acute Appendicitis Age >14 years Lower / RIF Abdominal Pain Clinical Suspicion of Acute Appendicitis i.e Alvarado Score 5-6 (equivocal for acute appendicitis) Alvarado Score 7-8 (probably appendicitis) Alvarado Score 9-10 (highly likely appendicitis) Informed consent (patient or legal representative) Diffuse peritonitis Antibiotic (Penicillin) documented allergy Ongoing previously started antibiotic therapy Previous appendectomy Positive pregnancy test IBD history or suspicion of IBD recrudescence | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Must be Age greater than or equal to 18 Obtain informed written consent Diagnosed with acute pulmonary embolism (PE) (< 14 days) Catheter-directed therapy (CDT) was performed to treat acute PE | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 0.0-999.0, Femoral Neck Fracture femoral neck fracture partial hip replacement r/o infection reoperation mental change | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-65.0, Postoperative Pain laminectomy r/o infection reoperation mental change allergy to local anesthetics | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Medical Prevention Therapy Objectively confirmed VTE Initiation of enoxaparin treatment within Day 0-10 after diagnosis of VTE Outpatients who will be treated with enoxaparin + VKA in combination are permitted to receive initial treatment other than enoxaparin for a maximum of 48 hours or 2 treatment doses preceding entry into the study Outpatients on enoxaparin monotherapy are permitted to receive up to 10 days of treatment other than enoxaparin preceding entry into the study Medical or psychiatric disorders associated with altered cognition or mentation that precludes understanding of the informed consent process | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Nonalcoholic Fatty Liver Disease Coronary Artery Disease Patients at intermediate risk for significant CAD was admitted to the hospital with the diagnosis of chest pain or undergoing elective CT coronarography due to suspection of coronary artery disease Male and female 18years or older Able to provide written informed consent Intermediate Risk patients for having significant CAD is defined as chest pain or dyspnea in the presence of negative stress tests the absence of chest pain but positive stress tests the absence of chest pain and of positive stress tests but intermittent arrhythmias Acute coronary syndrome presentation ST segment deviation on ECG and/or Cardiac troponin elevation Chest pain in combination with positive tests for myocardial ischemia Hemodynamic instability on presentation Inability to write inform consent Age <18 years Participation in an investigational study within the previous 30days | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Venous Thromboembolism Neoplasms Patients with cancer and confirmed pulmonary embolism (PE) or deep vein thrombosis (DVT) of the leg who have been treated for minimally 6 and maximally 12 months with therapeutic doses of anticoagulants, i.e. LMWH or VKA or a new anticoagulant in a trial Written informed consent Indication for long-term anticoagulant therapy (e.g. because of metastasized disease, chemotherapy) Legal age limitations (country specific), minimum age at least 18 years Indications for anticoagulant therapy other than DVT or PE Any contraindication listed in the local labeling of LMWH or VKA Childbearing potential without proper contraceptive measures, pregnancy or breastfeeding Life expectancy <3 months | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Knee Arthroscopy Analgesia those undergoing knee arthroscopy for: diagnostic purposes, removal of loose bodies, articular cartilage debridement or, meniscectomy age over 18 years American Society of Anaesthesiologists (ASA) grade ≥3 arthroscopic assisted osteotomies a history of two or more prior procedures on the ipsilateral knee post-operative morbidities indirectly linked to the procedure (e.g. anaesthetic complications, DVT or PE) systemic steroid requirements previous intra-articular anaesthetic or steroid injection within the last three months intra-articular HA injection within the last nine months intra-articular sepsis within the previous three months prior history of knee arthroplasty, peri-articular fracture, ligamentous instability, inflammatory arthritis or a previous diagnosis of Complex Regional Pain Syndrome | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Osteoarthritis, Hip Total hip replacement for osteoarthrosis Living within 30 km from the hospital Motivated to attend training 2 times/week in 10 weeks Reduced functional ability measured as: HOOS score < 67 written informed consent Comorbidities such as cancer, neuromuscular diseases, heart diseases etc Cognitive impairment Body mass index > 35 Resurfacing prosthesis Scheduled additional prosthetic surgery in lower extremity within 6 months | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-65.0, Fracture Fixation Intra-Articular Fractures Acetabulum Acetabular fracture deemed to require open reduction and internal fixation by one of the three principle attending surgeons Fixation must require a single non-extensile posterior approach (Kocher-Langenbeck) Posterior wall, Posterior column, certain simple transverse and transverse associated with a posterior wall, T-type, and posterior wall-posterior column fracture types Ages 18-65 Patient or family must consent to the research protocol Not meeting the aforementioned Unstable hemoglobin levels for three days prior to acetabular surgery (i.e. no other bleeding sources) Revision surgery Surgery occurring more than two weeks post-injury History of blood dyscrasias or immunocompromised patients Patients with medical conditions requiring anticoagulation or INR above 1.5 Obese patients (BMI >35) Known ongoing infection (local or systemic) Pregnant women | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 0.0-0.077, Newborn Pain Respiratory Therapy Techniques Newborns up to 28 days with any weight and gestational age in ventilatory support or oxygen therapy and clinical indication for Physical Therapy Newborns with contraindication of respiratory therapy, those that had problems during any of the study procedures and changes in those suffering from respiratory support or oxygen therapy during data collection If there was failure to collect any of the parameters for evaluating the newborn also was no longer part of the sample | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 0.083-2.0, Acute Respiratory Failure PaO2/FiO2 ratio <300 Respiratory rate >50 breaths/min Chest x-ray compatible with pulmonary infection No clinical improvement after breathing oxygen at 8 l/min or more for at least 15 min Presence of an endotracheal tube or a tracheostomy before PICU admission Facial deformities Upper airway obstruction Cyanotic congenital heart disease Facial trauma Recurrent apnea Neuromuscular weakness Pulmonary hypoplasia Pulmonary vascular anomalies Imminent respiratory or cardiac arrest | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 60.0-85.0, Knee Osteoarthritis Osteoarthritis (OA) of the knee for >6 months moderate to severe pain immediately following a 50-foot walk knee pain primarily due to tibiofemoral OA and not from patellofemoral OA bilateral standing anterior-posterior radiograph demonstrating grade 2 or 3 OA of the target knee willing and able to participate in regular exercise for four months free from musculoskeletal limitations that would preclude resistance exercise participation free of abnormal cardiovascular responses during the screening graded maximal walk test unable to walk regular resistance exercise training (>3X week) within the past 6 months specific low back pain or acute back injury spinal stenosis that precludes walking one block due to neurogenic claudication any major injury to either knee within the prior 12 months any surgery to either knee within the last 12 months lumbar radiculopathy vascular claudication significant anterior knee pain due to diagnosed isolated patella-femoral syndrome or chondromalacia in either knee have had corticosteroid or viscosupplement injections within three months of study participation | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Venous Thromboembolism Postpartum Women must be at high risk for thromboembolism for one of the following reasons Known low risk thrombophilia (Known = diagnosed prior to enrollment and low risk thrombophilia includes heterozygous factor V Leiden or prothrombin gene variant or protein C deficiency or protein S deficiency. If not previously tested then assumed not to have thrombophilia) Immobilization (defined as >90% of waking hours in bed, of a week or more at any point in the antepartum period) OR any two of the following reasons Postpartum infection (fever (temperature>38.5oC) and clinical signs/symptoms of infection and elevated neutrophil count (higher than local lab normal)) Postpartum hemorrhage (Estimated blood loss >1000 ml during delivery and postpartum) Pre-pregnancy BMI >25 kg/m2 Emergency cesarean birth (emergency = not planned prior to onset of labour) Smoking >5 cigarettes per day prior to pregnancy Preeclampsia (blood pressure ≥ 140mmHG systolic and/or ≥90 mmHg diastolic on at least one occasion and proteinuria (1+ on urine dipstick or 300mg/dl or total excretion of 300mg/24 hours) or typical end-organ dysfunction Less than 6 hours or more than 36 hours since delivery at the time of randomization Need for anticoagulation as judged by the local investigator, may but not limited to Personal history of previous provoked or unprovoked VTE (DVT or PE) Continuation of LMWH that was started in the antenatal period for VTE prophylaxis Mechanical heart valve Known high-risk thrombophilia (Known = diagnosed prior to enrolment and high-risk thrombophilia includes deficiency of antithrombin (at least 1 abnormal lab result), persistently positive anticardiolipin antibodies (> 30U/ml on two measurements a minimum of six weeks apart), persistently positive Anti B2 glycoprotein antibodies (> 20U/ml on two measurements a minimum of six weeks apart), persistently positive lupus anticoagulant (positive on two measurements a minimum of six weeks apart), homozygous factor V Leiden (FVL), homozygous prothrombin gene mutation (PGM), compound heterozygosity factor V Leiden (FVL) and prothrombin gene mutations (PGM), more than 1 thrombophilia (any combination of 2 or more: FVL, PGM, protein C deficiency, protein S deficiency). If not previously tested then assumed not to have thrombophilia) Contraindication to heparin therapy, including History of heparin induced thrombocytopenia (HIT) Platelet count of less than 80,000 x 106/L on postpartum Complete Blood Count(CBC) Hemoglobin ≤ 75 g/L on postpartum CBC | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Thoracotomy Chronic Pain Age > 18 Able to cooperate able to speak and read Danish repeat surgery cognitive dysfunction other nerve injury on the thorax abuse (medicine/ alcohol etc) | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 40.0-75.0, Lung Cancer Pulmonary Complications medical diagnosis of lung cancer and an indication for lung resection (lobectomy, bilobectomy and pneumonectomy) with posterolateral thoracotomy aged between 40 and 75 years Patients who refused to participate in the survey lung resection with incisions other than posterolateral patients who had contraindications to the use of noninvasive ventilation | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-65.0, Postoperative Pain Tonsillectomy mental change allergy to local anesthetics | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Axial Spondyloarthritis Male and female subjects aged 18 years and over at the time of consent to the study Diagnosis of SpA, as defined by the ASAS for axial SpA Axial involvement refractory to previous or current intake of NSAIDs, defined as at least 2 NSAIDs at maximum tolerated dose determined from past medical history taken for a duration of > 1 month (for both NSAIDs combined) before the Screening visit Active axial involvement defined by mini Subjects who are investigational site staff members or subjects who are Pfizer employees directly involved in the conduct of the trial Subjects who have received any previous treatment with etanercept or other TNFα inhibitors or biologic agents Subjects with a known or expected allergy, contraindication, or hypersensitivity to etanercept or its excipients | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 17.0-999.0, Venous Thromboembolism Delivery of Health Care Quality Improvement Inpatients with age > 17 years old Outpatients Inpatients with age less than or equal to 17 years old | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 15.0-999.0, Pain Pain, Postoperative Funnel Chest Patients undergoing minimally invasive repair of pectus excavatum Age > 15 years old Previous thoracic surgery interventions Disorders affecting the central or peripheral nervous system Chronic pain (pain intensity assessed by numerical rating scale > 3) Inability to speak and understand Danish (instructions, questionnaires) Inability to understand and participate in experimental pain modulation Psychiatric disorders (ICD-10) A history of frostbite in the non-dominant upper limb Sores or cuts on non-dominant upper limb Cardiovascular disease A history of fainting and/or seizures | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Total Hip Arthroplasty Patients scheduled for unilateral total hip replacement Consent to spinal anaesthesia ASA Grade I to III Patient refusal Mini-Mental Score < 25 Allergy to bupivacaine, morphine, paracetamol, diclofenac Skin lesions/infection at site of injection Uncorrected renal dysfunction Coagulation disorders chronic pain condition other than hip pain | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Ovarian Carcinoma Fallopian Tube Cancer Primary Peritoneal Cancer Subjects who have received at least one vaccine under protocol UPCC-19809 or UPCC-29810 ECOG performance status 0 or 1 Subject has sufficient vaccine (2 vaccine doses are sufficient) Must be at least 4 weeks post-operative Blood coagulation parameters: PT such that international normalized ratio (INR) is less than1.5 (or an in-range INR, usually between 2 and 3, if a subject is on a stable dose of therapeutic warfarin for management of venous thrombosis including pulmonary thromboembolus) and a PTT less than1.2 times the upper limit of normal Subject must be 18 years of age or older Life expectancy of greater than 4 months Normal organ and bone marrow function as defined by: Absolute neutrophil count greater than 1,000/microliter, Platelets greater than 100,000/microliter, Hematocrit greater than 30%, AST (SGOT)/ALT(SGPT) less than 2.5 X institutional upper limit of normal, Bilirubin less than 2.0 mg/dL unless secondary to bile duct blockage by tumor, and Creatinine less than 1.8 mg/dL Subjects who require or are likely to require more than a two-week course of corticosteroids for intercurrent illness. Subjects must complete therapy prior to enrollment. Topical corticosteroids should be stopped at least 2 weeks prior to enrollment and systemic corticosteroids should be stopped at least 4 weeks prior to enrollment Subjects with any acute infection that requires specific therapy. Acute therapy must have been completed at least seven days prior to study enrollment Subjects with any underlying conditions, which would contraindicate therapy with, study treatment (or allergies to reagents used in this study) Subjects with prior history or symptoms suggestive of partial or complete bowel obstruction Subjects receiving class III antiarrythmic medications Subjects receiving medications that might affect immune function. Additionally, H2 blockers are excluded, as are all antihistamines five days before and five days after each injection of study drug. NOTE: The following are exceptions: Proton pump Inhibitors (PPIs), including COX-2 inhibitors, acetaminophen Subjects who are allergic to Aspirin are excluded Development of clinically significant co morbid disease that would contraindicate study therapy or confuse interpretation of study results Subjects with a History of bowel obstruction, including sub-occlusive disease, related to the underlying disease and history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess Subjects with evidence of recto-sigmoid involvement by pelvic examination or bowel involvement on CT scan or clinical symptoms of bowel obstruction | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 40.0-80.0, Pulmonary Disease, Chronic Obstructive Type of subject: outpatient Informed consent: Subjects must give their signed and dated written informed consent to participate Gender: Male or female. Female subjects must be post-menopausal or using a highly effective method for avoidance of pregnancy. The decision to or women of childbearing potential may be made at the discretion of the investigator in accordance with local practice in relation to adequate contraception Age: >=40 and <=80 years of age at Screening (Visit 1) Tobacco use: Subjects with a current or prior history of >=10 pack-years of cigarette smoking at screening (Visit 1). Previous smokers are defined as those who have stopped smoking for at least 6 months prior to Visit 1 Airflow Obstruction Subjects with a measured post-albuterol/salbutamol forced expiratory volume in 1 second (FEV1)/(forced vital capacity)FVC ratio of <=0.70 at Screening (Visit 1) Subjects with a measured post-albuterol/salbutamol FEV1 >=50 and <=70% of predicted normal values calculated using III reference equations [Hankinson, 1999; Hankinson, 2010] at Screening (Visit 1) Post-bronchodilator spirometry will be performed approximately 15 minutes after the subject has self-administered 4 inhalations (i.e., total 400mcg) of albuterol/salbutamol via a metered dose inhaler (MDI )with a valved-holding chamber. The FEV1/FVC ratio and FEV1 percent predicted values will be calculated Symptoms of COPD: Subjects must score 2 or higher on the modified Medical Research Council Dyspnea scale (Visit 1) Pregnancy: Women who are pregnant or lactating Asthma: Subjects with a current diagnosis of asthma. (Subjects with a prior history of asthma are eligible if they also have a current diagnosis of COPD) alpha 1-antitrypsin deficiency: Subjects with known alpha-1 antitrypsin deficiency as the underlying cause of COPD Other respiratory disorders: Subjects with active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, pulmonary fibrosis, pulmonary hypertension, interstitial lung diseases or other active pulmonary diseases Lung resection or transplantation: Subjects with lung volume reduction surgery within the 12 months prior to Screening or having had a lung transplant A moderate/severe COPD exacerbation that has not resolved at least 14 days prior to Visit 1 and at least 30 days following the last dose of oral corticosteroids (if applicable) Current severe heart failure (New York Heart Association class IV). Subjects will also be excluded if they have a known ejection fraction of <30% or if they have an implantable cardioverter defibrillator (ICD) Other diseases/abnormalities: Any life-threatening condition with life expectancy <3 years, other than vascular disease or COPD, that might prevent the subject from completing the study End stage chronic renal disease: Subjects will be excluded if on renal replacement therapy (hemodialysis or peritoneal) Drug/food allergy: Subjects with a history of hypersensitivity to any of the study medications (e.g. beta-agonists, corticosteroid) or components of the inhalation powder (e.g. lactose, magnesium stearate). In addition, patients with a history of severe milk protein allergy that, in the opinion of the study physician, contraindicates the subject's participation will also be excluded | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-85.0, Postoperative Pain level posterior lumbar fusion mental change allergy to local anesthetics chronic analgesics user | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pulmonary Embolism patients with acute pulmonary embolism diagnosed in the emergency departement patient under guardianship patient without social insurance pregnant women refusal to sign the consent myocardial infarction in the 10 days before pulmonary embolism | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Malignant Pleural Mesothelioma Subjects must have histologically confirmed MPM (epithelial or biphasic) Subjects must have completed standard first line therapy with a platinum-based double regimen and had PD or they must have chosen not to pursue primary standard of care therapy ECOG performance status 0 to 1 Age greater than 18 years Life expectancy > 4 months At least 2 weeks since prior and no other concurrent chemotherapy, radiotherapy, or immunotherapy (e.g., interferons, tumor necrosis factor, interleukins, or monoclonal antibodies). In addition, the patient must have fully recovered from any adverse events related to these agents More than 4 weeks since prior and no other concurrent investigational agents Subjects must have measurable disease as defined by accepted MPM measurement techniques (modified criteria) Blood coagulation parameters: PT such that international normalized ratio (INR) is < 1.5 (or an in-range INR, usually between 2 and 3, if a subject is on a stable dose of therapeutic warfarin for management of venous thrombosis including pulmonary thromboembolus) and a PTT < 1.2 times the upper limit of normal Subjects must have adequate venous peripheral access for apheresis. Patients must also have adequate venous access for subsequent modified CIR T-cell administration which can be done through a central venous access (e.g. port of systemic chemotherapy) Previously treated with any investigation therapy within 1 month prior to screening Sacromatoid MPM histology which does not express mesothelin Prior invasive malignancies unless surgically and medically cured without evidence of recurrent disease for 5 years with the exception of non-melanoma skin cancer, prostate cancer with PSA level < 1.0 Prior hematologic malignancy with bone marrow transplantation or immune modifying therapy within the past 4 weeks with the exception of thyroid replacement Use of immunosuppressive drugs with 4 weeks prior to study entry, or anticipated use of immunosuppressive agents Any clinically -significant pericardial effusion, CHF (NY Heart Association Grade II-IV ), or cardiovascular condition Any clinically -significant pleural effusion or ascites that cannot be drained with standard approaches or with pre-enrollment in dwelling drainage device placement Forced vital capacity < 50% predicted, DLCO < 40% predicted Underlying lung disease requiring supplemental oxygen therapy Have a recognized immunodeficiency disease including cellular immunodeficiency, hypogammaglobulinemia, or dysgammaglobulinemia; patients who have acquired hereditary, congenital immunodeficiency | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-99.0, Urinary Incontinence includes English-speaking women over the age of 18 who have been admitted to the Rehabilitation Institute of Chicago with reports of urinary incontinence in the past 3 months. Those who report "yes" to the screening questions who fit the above will be screened by the principal investigator to ensure they fall into the criteria Non-English speaking women under the age of 18, or those that do not give consent to participate in the study will not be enrolled. Also excluded will be any woman who has any chance of being pregnant or having an active urinary tract infection. No women with active infection lesions, unknown vaginal bleeding or those who have never had any kind of pelvic examination will be included in the study. Other women with a neurogenic bladder or admission FIM scores on sections Comprehension and Memory of below 4. Women with reports of significant pelvic pain or recent pelvic surgery or radiation or post-partum in last 6 months will be excluded | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-75.0, Pulmonary Thromboembolisms Pulmonary Embolism 18 y≤Age≤75y Acute PE (first symptoms occurred 14 d or less before randomization) confirmed by lung scan, or a positive computed tomographic pulmonary angiogram, or a positive selective pulmonary angiogram Hemodynamic stability, diastolic pressure>90mmHg RV dysfunction confirmed by echocardiography (≥1 criterion), except left-side heart disease, congenital heart disease and mitral valve disease Increase of the right ventricle showed presented with RV end-diastolic anteroposterior diameter >25 mm, Right/left ventricular end-diastolic diameter >1 (apical or subcostal 4-chamber view) or Right/left ventricular end-diastolic anteroposterior diameter >0.5 Hypokinesis of RV-free wall (range of motion less than 5 mm) Tricuspid regurgitation pressure >30mmHg RV anterior wall thickness > 5mm confirmed by echocardiography Active internal bleeding and spontaneous intracranial hemorrhage in preceding 6 months Major surgery, organ biopsy or non-compressible punctures within 2 weeks Ischemic stroke occurred within 2 months Gastrointestinal bleeding within 10 days Severe trauma occurred within15 days Neurosurgery or eye surgery within 1 months Severe hypertension difficult to control (systolic blood pressure>180mmHg or diastolic blood pressure>110mmHg) Cardiopulmonary resuscitation Platelet count less than 100×109 / L | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 19.0-999.0, Air Embolism as A Complication of Medical Care Subject is undergoing ERCP as part of their medical care Subject will be of age 19 or older Subject positioning for the ERCP is prone, thereby inhibiting the performance of the TTE Subject intolerance of the pressure of the TTE probe Subject body habitus interferes with obtaining adequate images to assess for intra-cardiac air | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-70.0, Degenerative Joint Disease of Hip and Knee. Undergoing a hip arthroplasty, total knee arthroplasty, hip fracture repair American Society of Anesthesiologist rating I-III as determined by your anesthesiologist Pregnancy and breast feeding An allergy to any of the drugs to be used in the study (midazolam, Celecoxib, gabapentin, hydromorphone, bupivacaine) History of a sleep disorder (Obstructive sleep apnea or daytime somnolence) History of taking chronic narcotic pain medications or gabapentin History of rheumatoid arthritis, a psychiatric disorder, or diabetes with impaired renal function History of alcohol or illicit drug abuse History of a kidney or liver problem Inability or unwilling to use patient-controlled analgesia Unable to meet the for removal of the endotracheal tube in the Operating Room History of asthma, hives or an allergic type reaction following an aspirin or other drug such as Ibuprofen | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Traumatic Rib Fracture A subject must meet the following to take part in the study Subjects 18 years of age and greater Inpatient on the BWH SICU, MICU, or hospital floor ward Non-intubated at the time of block placement Traumatic Rib Fractures three or greater Block able to be placed within 12-24 hours of presentation to the emergency room Ability to provide written informed consent Compliance with all ASRA and BWH Regional Anesthesia in Anticoagulated Patient guidelines for coagulation status Subject is pregnant Subject not expected to survive 48 hours due to traumatic injuries Allergy to Ropivacaine or other local anesthetic Any significant concomitant injuries potentially confounding data acquisition (e.g., traumatic brain injury, long bone fractures, intra-abdominal injuries) Known allergy to lidocaine Inability to provide written, informed consent Known opioid medication dependence Non-compliance with ARSA and BWH Regional Anesthesia in Anticoagulated Patient Guidelines | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Acute Pulmonary Embolism consecutive patients with acute pulmonary embolism age <18 years | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-65.0, Postoperative Pain Total thyroidectomy mental change allergy to local anesthetics | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-65.0, Postoperative Pain Laparoscopic cholecystectomy mental change allergy to local anesthetics | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 0.0-999.0, Pulmonary Embolism Pulmonary Embolism Without Mention of Acute Cor Pulmonale all patients referred to the ICU with suspected APE | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Patients with clinical suspected pulmonary embolism Simplified Well's score>4 (PE likely) or D-dimer value ≥500ng/ml Patients that undergo MCTPA in the Emergency Department for suspected pulmonary embolism Refused consent Less than 18 years old Not possible to perform ultrasound scan within 3 hours before MCTPA | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 40.0-80.0, Coronary Disease non-acute chest pain those who underwent CT calcium scoring availability of all relevant risk factor information previous coronary disease i.e., myocardial infarction or revascularization | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Atrial Fibrillation patients with atrial fibrillation foreseen for Pradaxa anticoagulation according to physician's decision for stroke prevention patients with mild or moderate renal impairment age >= 18 years at enrollment severe renal impairment (Creatinine Clearance < 30 ml/min) | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 16.0-999.0, Chest Pain All patients over the age of 18 years presenting with the leading symptom of first time or recurrent acute chest pain in the emergency room of the Department of Internal Medicine, University Hospital of Zurich Missing informed consent Cardiopulmonary unstable patients No self reported chest pain Recent thoracic surgery within1 year, inflammatory joint disease, fibromyalgia, cardiogenic shock | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Hyperglycemia Hypercholesterolemia Persistent Postoperative Pain Hip Replacement Knee Replacement Primary hip and knee replacement for osteoarthritis Enrolled previously into study NCT01021826 Arthritis other than osteoarthritis (based on study NCT01021826) Medication affecting glucose metabolism (excl. antidiabetic agents) (based on study NTC01021826) Died before follow-up phase Did not undergo the planned hip or knee replacement | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Deep Vein Thrombosis Pulmonary Embolus ≥ 18 years Investigator judges caval filtration clinically indicated for prevention of pulmonary embolism in patient with venous thromboembolic disease or at high risk for venous thromboembolic disease. Patient must meet at least one of the following Anticoagulant therapy is contraindicated, has failed, cannot be achieved or maintained, must be interrupted, resulted in complication, or places the patient at high risk of complication and the patient has Pulmonary embolus Iliocaval deep vein thrombosis (DVT) Severe trauma with high risk of venous thromboembolism including closed head injury, spinal cord injury, or multiple long bone or pelvic fractures Surgery planned with high risk of venous thromboembolism including procedures such as bariatric, orthopedic, or pelvic surgery Past history of thromboembolic disease undergoing surgery Therapeutic anticoagulation can be achieved, but the patient has Venous thromboembolism such as pulmonary embolism or DVT with limited cardiopulmonary reserve Condition that inhibits radiographic visualization of the IVC Known inadequate venous anatomy to allow insertion or retrieval of the filter from the IVC including occlusion of the SVC or jugular veins Known IVC transverse diameter at target implant site > 28 mm Known obstructing abdominal mass or anatomy that is not suitable for infra-renal placement of IVC filter Known duplication of IVC or left-sided IVC Severe kyphosis or scoliosis Known IVC thrombosis extending to renal veins, or renal or gonadal vein thrombosis Risk for septic pulmonary embolism Confirmed bacteremia Estimated Glomerular Filtration Rate (eGFR) < 30 ml/min, or dialysis dependent | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Venous Thromboembolism Subjects must provide informed consent Men or women aged 18 years or more Ongoing cancer disease recent diagnosis of veinous thromboembolism treatment with Low Molecular Weight Heparin before entry into the study Contraindication to the use of Low Molecular Weight Heparin | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 16.0-999.0, Cancer Thrombosis Venous Thromboembolism Deep Vein Thrombosis Pulmonary Embolus Receiving LMWH for treatment of CAT for five months Locally advanced or metastatic cancer Able to self-administer LMWH, or have LMWH administered by a carer Able to give informed consent Age ≥16 years Receiving drug other than LMWH for CAT Contraindication to anticoagulation Fitted with a prosthetic heart valve Pregnant and/or lactating females | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-99.0, Breast Cancer signed an Institutional Review Board (IRB)-approved informed consent document for protocol age >= 18 years histologically confirmed left-sided breast cancer scheduled to undergo curative intent radiation treatment post lumpectomy or mastectomy stage 0-III left-sided breast cancer (including DCIS) SPECT score of 0 at baseline radiation oncologist agrees target volume coverage will not be compromised via use of the DIBH technique along with conformal field shaping active cardiac disease, defined as a history of angina, arrhythmias, myocardial infarction, congestive heart failure, or any other cardiac condition, which in the opinion of the treating physician would make this protocol unreasonably hazardous for the patient symptomatic pulmonary disease currently requiring regular medication including but not restricted to bronchodilators concurrent chemotherapy prior receipt of mediastinal radiation therapy pregnant or lactating women inability to understand and follow breathing instructions for the DIBH procedure | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Atrial Fibrillation Deep Vein Thrombosis Pulmonary Embolism age 18 years or above after study start index date on or after study start signed, informed consent patients treated for DVT or PE patients with non-valvular AF (with one or more risk factors) treated for prevention of stroke and systemic embolism any use of univalent direct thrombin inhibitor or direct factor Xa inhibitors use of anticoagulant therapy or other vitamin K antagonists recorded within one year prior to index date | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pulmonary Embolism years of age or greater Agrees and able to participate in the study Room air SpO2 (oxygen saturation) less than 92% and newly-diagnosed PE (or controls with no PE) based on CT angiogram result Clinical concern for instability Systolic blood pressure less than 100 mm Hg Heart rate ≥140 beats per minute Oxygen saturation less than 85% with more than 4 L supplemental oxygen Unable to participate/comply with instructions for using the incentive spirometer Patients from the Federal Medical Center in Rochester, Minnesota Patients who do not speak English (due to the need for expediency) Patients will be under the care of the Emergency Department team who have the skills and resources to monitor and treat patients if they were to become unstable | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Multiple Pulmonary Emboli Patients referred for CT pulmonary angiogram to pulmonary embolus Class 3 or 4 Congestive Heart Failure Supraventricular tachycardia History of contrast allergy Unable to give informed consent Patients with serum creatinine >1.28 mg/dl without referring physician approval | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 50.0-999.0, Diabetes Diabetes Mellitus, Type 2 Type 2 diabetes Age above or equal to 50 years with predefined previous cardiovascular disease(s) or renal disease or age above or equal to 60 years with predefined cardiovascular risk factors HbA1c (glycosylated haemoglobin) above or equal to 7.0% or HbA1c below 7.0% and current insulin treatment corresponding to above or equal to 20 U of basal insulin per day One or more oral or injectable antidiabetic agent(s) An acute coronary or cerebrovascular event in the previous 60 days Planned coronary, carotid or peripheral artery revascularisation Chronic heart failure NYHA (New York Heart Association) class IV Current or past (within the last 5 years) malignant neoplasms (except basal cell and squamous cell skin carcinoma) | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-80.0, Acute Pancreatitis Complication of Ventilation Therapy Diagnosis of pancreatitis:typical pain, increase in serum lipase or amylase, onset of abdominal pain within 72h before admission The diagnosis of Severe Acute Pancreatitis is according to Atlanta revisited in 2012 the diagnosis of ARDS meets the of Berlin definition chronic respiratory disease as chronic obstructive pulmonary disease (COPD), asthma organic cardiopathy pregnancy | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-75.0, Cardiac Disease Patients aged 18-75 years inclusive and American Society of Anesthesiologists physical status 2-4 Undergoing minimally invasive cardiac surgery Subjects must be physically and mentally able to participate in the study and complete all study assessments Subjects must be able to give fully informed consent to participate in this study after demonstrating a good understanding of the risks and benefits of the proposed components of thoracotomy and chest tube sites infiltration History of hypersensitivity or idiosyncratic reactions to amide-type local anesthetics Any subject whose anatomy, or surgical procedure, in the opinion of the Investigator, might preclude the potential successful performance of a thoracotomy and chest tube sites infiltration Any subject who in the opinion of the Investigator, might be harmed or be a poor candidate for participation in the study Any subject, who in the opinion of the Investigator, is on chronic pain medicine, including large doses of nonsteroidal antiinflammatory drugs Subjects who have received any investigational drug within 30 days prior to study drug administration, or planned administration of another investigational product or procedure during their participation in this study | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-75.0, Chest Pain patients undergoing removal of a chest tube after lung surgery patients able to indicate the pain score pregnancy, lactation insulin-dependent diabetes with dysautonomia central or peripheral neurological disease, agitation inability to understand the protocol inability to use the Pain Monitor: skin abnormalities at the site of measurement, pacemaker or implantable defibrillator, condition affecting the sympathetic nervous system, tremor of the extremities contra-indication to oral morphine respiratory failure, severe hepatic insufficiency, intracranial hypertension, epilepsy associations recent administration of neostigmine or of atropine | 1 |
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