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A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Spinal Muscular Atrophy Amyotrophic Lateral Sclerosis Spinobulbar Muscular Atrophy ENTRY --Disease Characteristics-- Men aged 18 and over with motor neuron disease, i.e X-linked spinal and bulbar muscular atrophy (Kennedy's disease) Confirmed by androgen receptor, exon-1 mutation genotype Amyotrophic lateral sclerosis Spinal muscular atrophy Significant muscle weakness on manual muscle testing No prisoners No mental disability | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Dystonia Healthy Healthy volunteers who consented to participate in the study and matched for age, sex, handedness with the group of patients with primary focal hand dystonia Patient with primary focal dystonia from our dystonia patient database who consented to participate in the study. This criterion will be established by the preliminary screening in the Human Motor Control Outpatient Clinic The following subjects will be excluded Healthy volunteers with cognitive complaints, abnormal neurological exam or history of past neurological disease Dystonia patients with the presence of a second neurological disease or condition; abnormal neurological findings on exam that are not related to primary focal dystonia Subjects with past or present neuropsychiatric illness, head trauma with loss of consciousness, epilepsy, cerebro-vascular disease, migraine, past and present history of alcohol abuse, medical conditions that may alter cerebral structure Subjects with abnormal MRI findings at visual inspection (prominent normal variants such as mega cisterna or cavum septum pellucidum, signs of severe cortical or subcortical atrophy, brain tumors, vascular diseases, trauma or AVMs) Subjects with any metallic objects within them just prior to MR imaging (cardiac or neural pacemaker, aneurysm clips [metal clips on the wall of a large artery], metallic prostheses [including heart valves and cochlear implants] or shrapnel fragments. Welders and metal workers are also at risk for injury and may not take part in the study because of possible small metal fragments in the eye of which they may be unaware Subjects not capable of giving an informed consent Women who are pregnant Children | 1 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 21.0-999.0, Parkinson Disease We will only PD patients with a stable clinical response to L-DOPA and DAergic agents We will only recruit patients with early or mild-to-moderate PD (score on Hoehn & Yahr scale 148 less than 3) To obtain a homogeneous group, the PD cohort will comprise only non-demented, non-depressed, with parkinsonian symptoms and signs primarily akineto-rigid If resting tremor is present, only patients with mild or moderate tremor (UPDRS tremor ratings 1 or 2 in the right upper limb) will be included in the study Our group of healthy volunteers will the following age range: 21-30 years, 31-40 years, 41-50 years, 51-60 years, 61-70 years, and 70 years and over Research subjects may be male or female and they must be right-handed Pregnant women will not participate in the study Research subjects will be asked to refrain from caffeine and nicotine for at least 12 hours and to abstain from alcohol at least 24 hours before the fMRI Subjects belonging to one of the following groups will be excluded from the study Subjects with a familial history of PD Patients with a marked resting tremor (score at the UPDRS scale above 3 in the right upper limb) Patients with a score at Hoehn & Yahr scale equal or above 3 Patients with progressive neurological disorders other than PD Subjects with cognitive impairment (i.e., score on Mattis scale below 123/144) Subjects with significant mood disturbances (i.e., score on BDI scale above 10) Subjects with abnormal MRI findings at visual inspection (prominent normal variants such as mega cisterna or cavum septum pellucidum, signs of severe cortical or subcortical atrophy, brain tumors, vascular diseases, trauma or AVMs) Subjects with a history of significant medical disorders, or requiring chronic treatment with other drugs that cannot be stopped Subjects with prior exposure to neuroleptic agents or drug use | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 0.0-999.0, Pick Disease of the Brain -Six patients referred to the Cognitive Neuroscience Section, NINDS, with a clinical diagnosis of FTD confirmed here, will be selected to participate in the study Greater than 75 years of age Presence of metal in the head other than dental hardware Broken skin in the area of the stimulating electrodes Any behavioral disorder that makes testing impossible Children are excluded, as FTD is not a childhood illness | 1 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 12.0-999.0, Prion Disease Aged 12 years or more, diagnosed with any type of human prion disease In a coma, or in a pre-terminal phase of disease such that prolongation of the current quality of life would not be supported Known sensitivity to quinacrine Been taking any other putative anti-prion therapy for less than 8 weeks | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 45.0-999.0, Menopause Postmenopausal Vaginal Atrophy Postmenopausal women whose last menstruation was at least two years previously | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-80.0, B Cell Lymphoma • Patients with one of the following B-cell Lymphoma CD 20 positive : Mantle cell, Marginal zone, lymphocytic, follicular requiring treatment, Histological transformation from low grade to high grade, diffuse large cell without adverse prognostic factors defined by the international prognostic index (IPI) Aged from 18 to 80 years Untreated with chemotherapy except with Chlorambucil or Cyclophosphamide per os alone less than 6 months Previous radiotherapy except if localized Performance status < 3 Signed inform consent Other type of lymphomas: Burkitt, T cell, CD 20 negative Central nervous system or meningeal involvement Contraindication to any drug contained in the chemotherapy regimen HIV disease, active hepatitis B or C Treatment with polychemotherapy before except with Chlorambucil or Cyclophosphamide per os less than 6 months Prior extended radiotherapy Any serious active disease or co-morbid medical condition (according to investigator's decision ) Renal deficiency (clearance < 30 ml/mn), liver deficiency (bilirubin > 30 mmol/l) unless related to lymphoma Neuropathy> grade 2 within 14 days before enrollment Platelets < 30.109/l within 14 days before enrollment | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 0.0-999.0, Dementia Mild Cognitive Impairment Diagnosis of dementia under the DSM-IV or of Mild Cognitive Impairment, using the Peterson Living in the community (home, apartment or collective housing with nursing care available for less than 40 hours per week) Patient able to provide written informed consent, or provision of written informed consent by a legal guardian/proxy Availability of a caregiver willing to provide consent for required components of the study Fluent in English May be participating in a Phase IV or other post-marketing follow up study of an approved product for treatment of dementia No concomitant life-threatening illness (a condition which is likely to interfere with the patient's ability to complete the study) Not unwilling or unable to complete the study Not concurrently participating in a clinical trial of an investigational drug (phase I, II or III) Unwillingness of patient or legal guardian / proxy to provide written informed consent Unwillingness of caregiver to provide written informed consent For patients with diagnosis of mild cognitive impairment: current or previous treatment with any cholinesterase or memantine | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-90.0, Alzheimer's Disease Mild Cognitive Impairment Healthy for patients with dementia Patients: clinical diagnosis of AD or mild cognitive impairment primary language German for healthy subjects and patients with dementia/MCI Known allergy to levodopa or tetrazine History of medication/drug abuse Acute nicotine withdrawal or > 15 cigarettes per day > 6 cups/glasses of coffee, caffeine drinks or energy drinks per day > 50 grams of alcohol per day Severe hypertonia (systole >160 mm Hg) Severe arteriosclerosis Diabetes, asthma, or glaucoma Severe hearing disability | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 0.0-999.0, ALS Cases were eligible to participate in the original study if (1) they had received a diagnosis of ALS within 2 years; (2) they lived in New England at least half the year; (3) they spoke English; (4) they were mentally and physically able to participate. The same were used for controls Potential controls were excluded if they had a physician diagnosis of a neurodegenerative disease, polio, post-polio syndrome, or nondiabetic neuropathy Pregnant women were excluded from both case and control groups | 1 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-60.0, Multiple Sclerosis Diagnosis of relapsing remitting or secondary progressive with superimposed relapses MS Age between 18 and 60, inclusive EDSS between 0 and 6.5 Receiving treatment with Interferon beta (either 1a or 1b) at fully tolerated dose for at least 6 months prior to enrollment and with evidence of clinical efficacy (i.e. reduction or absence of clinical relapses) at the time of the enrollment Clinical relapse at the time of the enrollment or within the previous 3 months Undergoing chronic therapy with any other immunomodulatory or immunosuppressive medication (excluding standard dosages of steroids intravenously/intramuscularly injected and orally taken for the treatment of relapses) besides Interferon within the past 6 months Currently taking medications used for treatment of cognition/fatigue such as Donepezil (Aricept), Modafinil (Provigil), Amantadine, or other drugs that may act as temporary stimulants or depressants for the central nervous system Currently taking other medications used for symptomatic relief that may affect cognition. The study neurologist will make the determination of eligibility Clinically significant medical condition that, in the opinion of the investigator, would compromise patient's safety or affect his/her MRI (e.g., diabetes mellitus, chronic hypertension, severe anemia, kidney disease, heart disease [angina, arrhythmias, congestive heart failure]) Pregnancy or current breastfeeding Previous eye surgery of any kind Inability to provide informed consent. The ability of the patients in understanding all the aspects of the protocol will be judged by the means of a questionnaire Permanent tattooed makeup (eyeliner, lip, etc.) or general tattoos. Subjects with tattoos will be excluded if those are in a dangerous location in the body or made with colors whose content in iron (e.g. dark blue or dark green) cannot be definitely ruled out by the Investigators Any non-organic implant or any other device such as: cardiac pacemaker, insulin infusion pump, implanted drug infusion device, cochlear, otologic, or ear implant, transdermal medication patch (nitro, hormones) that may cause problems if removed, even temporarily, any metallic implants or objects, body piercing(s), bone/joint pin, screw, nail, plate, wire sutures or surgical staples, shunt | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 0.0-999.0, Differentiated Thyroid Carcinoma Hiostologically proved DTC (M0) Preoperative metastasis | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-80.0, Central Nervous System Disease Cerebrovascular Accident Stroke Patients must be aged 18 or above with subacute (at least 3 months post stroke) thromboembolic or hemorrhagic strokes with impaired motor function in at least one of the limbs but capable of performing the required motor tasks. Assessment of the initial functional state will be taken at the initial visit at the NINDS Stroke Neurorehabilitation Clinic. Patients with additional stroke(s) during the length of the protocol will not be excluded from the study if the conditions stated in the are satisfied Patients with a history of alcohol or drug abuse, poor motivational capacity, or language disturbances, particularly of receptive nature or with serious cognitive deficits (defined as equivalent to a mini-mental state exam score of 23 or less) Patients with medical or technical contraindications to MRI procedures (e.g. metal braces, pacemakers, cochlear devices, surgical clips, and other metal/magnetic implants); claustrophobia; and pregnancy Patients who are unable to comply with the motor testing protocol | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 50.0-999.0, Parkinson's Disease Idiopathic Parkinson's in accordance to UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Born and raised in Denmark >50 years Cerebrovascular disease Dementia not caused by Parkinson's Disease Metabolism anomaly Abuse of drugs, medication or alcohol History of head injuries Severe psychiatric disorder, excluding depression Resident outside the region of Aarhus h) DBS - | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 1.0-18.0, Leukemia, Lymphocytic, Acute ALL, healthy | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 65.0-90.0, Healthy Enrolled in WHIMS At least 65 years old Not diagnosed with dementia Women younger than 65 years of age Have dementia not enrolled in WHIMS | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-90.0, Amyotrophic Lateral Sclerosis Neurodegenerative Disease Motor Neuron Disease In-patients with probable or definite ALS, ages 18 staying on the neurology floor of Hahnemann Hospital In-patients who do not meet the of the diagnosis of ALS | 1 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-90.0, Amyotrophic Lateral Sclerosis Neurodegenerative Disease Motor Neuron Disease Medical Subjects Be able to give consent themselves or via a legally authorized representative Diagnosed with a neuromuscular disease and have limited ability to communicate Be able to see visual cues such as targets or letters presented on the screen, and/or ability to hear auditory cues such as tones or words presented through speakers or earphones Be able to understand and remember instructions concerning participation Healthy control subjects Be able to consent to give consent themselves or via a legally authorized representative Be able to see visual cues such as targets or letters presented on the screen, and/or ability to hear auditory cues such as tones or words presented through speakers or earphones Be able to understand and remember instructions concerning participation Individuals with cognitive impairments that would impact their ability to follow the instructions | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 55.0-55.0, Spinal Cord Injury at C5-C7 Level With Incomplete Lesion an incomplete C6 ASIA C (Central Cord) spinal cord injury lower motor function impaired and suffers from significant spasticity (Ashworth scale 4) able to ambulate approximately 10-20 feet with a rolling walker and minimal assistance has sufficient endurance to complete at least two 20-minute therapy sessions per day cognitive abilities are intact psychiatric diagnosis medical contraindications history of bleeding disorders allergy to anesthesia acute or progressive disease active implantable device | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-79.0, ALS (Amyotrophic Lateral Sclerosis) and Subject will be a veteran with El Escorial "Lab Supported Probable" or more definite diagnosis of ALS Subject will have lost the ability to communicate either verbally or in writing (item 1 or item 4 on the ALS Functional Rating Scale-Revised (ALSFRS-R) score of 0, Appendix A) Subject will be an adult (age >18) Subject will be living at home Subject will be living within 100 miles of the participating study site Subject will have corrected visual acuity of at least 20/80 Subject will have the ability to read and understand 6th grade English text on a computer screen Subject will be able to indicate willingness and understanding of the consent form (using their existing method of communication) Subject will be able to identify one significant other Subject will identify one system operator (person that agrees to be trained and set up the BCI). This person can be the significant other | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 16.0-999.0, Multiple Sclerosis established SPMS according to the McDonald Patients with a history of drug/alcohol abuse, a premorbid (pre MS) psychiatric history, a head injury with loss of consciousness and a concurrent physical disease requiring medical attention (eg. cardiovascular disease etc), MRI contraindication including implants, pacemaker, aneurysm clips and known renal impairment | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 40.0-75.0, Atrophic Vaginitis Postmenopausal women (no menses for the previous 12 months) Dryness, itching or burning in and around the vagina Discontinued hormone replacement therapy (either local or systemic) at least 3 months Known, suspected, or history of cancer of the breast Known, or suspected estrogen dependent neoplasia (ovarian, endometrial) Known hypersensitivity to any component of the medications or base creams Active deep vein thrombosis, pulmonary embolism, or history of these conditions Active or recent (within the past year) arterial thromboembolic disease (stroke, myocardial infarct) Liver dysfunction or disease with elevation of aspartate aminotransferase (AST)>1.5x upper level of normal (ULN); Normal for females is 8-43 U/L Undiagnosed abnormal genital bleeding Known chronic lichen sclerosis Known, untreated vaginal infection Not had a normal screening mammogram within the last 15 months | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 0.0-999.0, Atrophic Rhinitis Symptoms of atrophic rhinitis, with previous clinical treatment without good results Patients with mental illness | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Breast Cancer Estrogen Receptor Her-2 Pgr Diagnosis of breast cancer Node positive OR high-risk node negative disease Tumor > 1.0 cm in diameter No locally advanced, inflammatory, or metastatic breast cancer Previously treated with 4 courses of anthracycline-containing chemotherapy (i.e., doxorubicin and docetaxel OR doxorubicin and cyclophosphamide) Enrolled on clinical trial ECOG-E2197 Adequate tumor material available in ECOG Pathology Coordination Center Previously consented to future cancer-related research Hormone receptor status known Female | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 30.0-60.0, General Paresis EEG MR Serological test | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-50.0, Traumatic Brain Injury Control subjects from 18-50 Patients from 18-50 who have suffered TBI Substance abuse Irremedial sensory deficits (blindness, deafness) Primary psychiatric disorder Neurological disease unrelated to TBI | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-65.0, Human Immunodeficiency Virus Hepatitis B Hepatitis C Human T-lymphotropic Virus I & II Creutzfeldt-Jakob Syndrome HIV Infections deferred blood donor status, and deferral due to a positive result of a routine blood test for HIV, or hepatitis B, or hepatitis C, or HTLV, or having been identified as at risk of vCJD; and deferral occured in 2008 or 2009 (2007 for the pilot; 2005 for those at risk of vCJD and the control group); and donor registered at one of the NHSBT centres (English Blood Service in England and Wales) not a blood donor; or no record of notification having taken place; or a member of Armed Forces or other profession where contact at the address provided could lead to a breach of confidentiality; or deferred before 2008 (if not in the pilot or notified of increased risk of vCJD) deferred as a result of a non-routine test or syphilis infection only; or donor registered with and notified by the Welsh, Scottish or Northern Irish Blood Services | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Vaginitis Dyspareunia Breast Neoplasms Histologically or cytologically confirmed breast cancer (any stage) Currently be using an aromatase inhibitor (anastrazole, exemestane or letrozole) for primary or adjuvant breast cancer treatment Must have complaints of vaginal itching, vaginal dryness and/or dyspareunia Not undergoing active chemotherapeutic or radiotherapeutic treatment Age >18 years Life expectancy of greater than 2 months CALGB (ZUBROD) performance status <3 Post-menopausal defined by absence of menses for at least 12 months and/or an FSH >25. Not post-menopausal as a function of medications intended to suppress ovarian function, such as gonadotropin releasing hormone agonists. Surgically post-menopausal subject eligible The effects of topical testosterone cream on the developing human fetus at the recommended therapeutic dose are unknown. For this study only post-menopausal women are included and all women of child-bearing potential are excluded. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately Patients who have not recovered from adverse events due to chemotherapeutic agents administered more than 4 weeks earlier History of allergic reactions attributed to compounds of similar chemical or biologic composition to testosterone or the emollient delivery cream used in the study Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements Pregnant women and women who are breast-feeding are excluded from this study because it is limited to post-menopausal women | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Shock, Septic patient (or representative) received the information notice patient has hemodynamic insufficiency of non-traumatic or cardiogenic origin associated with severe sepsis (treated with Noradrenalin) and organ dysfunction, hypoperfusion or hypotension body temperature > 38.3°C or < 36°C heart rate > 90 bpm Tachypnea > 20 C/min or PaCO2 < 32 mmHg or mechanical ventilation leukocytes > 12000 µL-1 ou < 4000 µL-1 ou > 10% immature forms oliguria < 0.5 ml/kg/h for at least 2 hours abrupt alteration (24 h) of conscienceness thrombocytopenia < 100 000 G/L or disseminated intravascular coagulation mottled skin and / or capillary refill time> 3 sec patient is dying or limitation or cessation of active treatment patient is already included in another trial patient or family refusal patient not affiliated with a social security system | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 50.0-80.0, Parkinson's Disease Medical clearance to perform an exercise tolerance test and training program A diagnosis of PD at stage 2 on the Hoehn and Yahr scale A neurological condition other than PD/ Anyone who is currently taking any vitamin supplementation Smokers Anyone currently engaged in weight training | 1 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 0.0-999.0, Alzheimer's Disease Gait Apraxia Impaired Cognition All elderly patients from the University Memory Center of Angers University Hospital Able to walk without any walking aid on 15 meters Mini-Mental Status Examination score > 10 Being affiliated to a social security regime Mini-Mental Status Examination score ≤ 10 Subject suffering from pre-existing impellent disturbances History of cerebrovascular accident or other cerebro-spinal pathology Poor workmanship of the written or oral French language Use of walking aid such as walking frame with wheels or tricycle Acute medical or surgical disease in the past 3 months Refusal to participate (or trustworthy person) Near visual acuity < 2/10 | 1 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 30.0-80.0, Stroke for patients wth stroke Age 40-80 years sustained a single stroke between 3-24 months prio t study leading to upper limb paresis have at least Stage 3/7 arm control (mild to moderate motor deficits) on the Chedoke-McMaster Scale <81 yrs old to minimize confounding effects of age-related changes in sensorimotor functions for patients wth stroke other neurological or orthopaedic problems that may interfere with interpretation of results significant deficits in attention, constructional skills, neglect and apraxia shoulder subluxation, arm pain lack of endurance as judged by a physician undergoing other therapy, surgery or medical procedures within the study period for healthy control subjects Age 40-80 years for control subjects any neurological or orthopaedic problems that may interfere with interpretation of results | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 0.0-999.0, Mumps Subjects with upper or lower limb spasticity Subjects must use botulinum injection for the first time | 2 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 55.0-95.0, Dementia, Alzheimer Type Non-institutionalized patients with a diagnosis of Alzheimer's disease as defined by Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) with symptoms of delusions or hallucinations, which have been present, at least intermittently for one month or longer Mini Mental State Examination (MMSE) score of 6 to 24 points Patients capable of self locomotion or locomotion with the aid of an assistive device Patients with an identified caregiver or proxy For Extension Phase Eligible patients were males and females who had completed the 10-week Acute Phase in either treatment group; had a Week 10 Total Score of ≥ 6 on the NPI; and were, in the judgment of the investigator, deemed suitable for participation in the long-term trial Treatment beyond 140 weeks All subjects who completed the extension phase of CN138-006 in any French Investigational Site may be considered eligible for entry until they are no longer receiving clinical benefit, per the investigator's judgment Patients with an Axis I (DSM IV) diagnosis of delirium amnestic disorders bipolar disorder schizophrenia or schizoaffective disorder mood disorder with psychotic features Patients with reversible causes of dementia Patients with psychotic symptoms continuously present since prior to the onset of the symptoms of dementia Patients with psychotic symptoms that are better accounted for by another general medical condition or by direct physiological effects of a substance Patients with a current major depressive episode with psychotic symptoms of hallucinations or delusions | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-35.0, Graft Versus Host Disease (GVHD) Acute Myocardial Infarction (AMI) Age 18 to 35 years Willingness to provide written informed consent Presence of risk factors for or clinical evidence of Human immunodeficiency virus (type 1 and 2), Hepatitis B, Hepatitis C, Human T-lymphotrophic virus (type I and II), Human transmissible spongiform encephalopathy (including Creutzfeldt-Jakob disease) treponema pallidum Presence of communicable disease risk associated with xenotransplantation Test positive for Human immunodeficiency virus (type 1 and 2), Hepatitis B, Hepatitis C, Human T-lymphotrophic virus (type I and II), cytomegalovirus (CVM), West Nile Virus, treponema pallidum Use of investigational drug within 30 days or 5 half lives which ever is longer. Use of investigational implanted device History of malignancy Pregnancy In the opinion of the hematologist or the investigator, a condition that compromises the ability of the donor to safely provide BM donation | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 0.0-999.0, Menopause Postmenopausal Vaginal Atrophy Atrophic vaginitis due to estrogen deficiency Post-menopausal | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 40.0-85.0, Parkinson's Disease Mild Cognitive Impairment Participants must be experiencing symptoms of mild cognitive impairment; this will be determined by study personnel Participants must be on a sable medication regimen for 2 months prior to starting the study (necessary dose adjustments during the study are acceptable) Participants are capable of giving informed consent supported by not meeting Parkinson's disease Dementia criteria; this will be determined by study personnel Active suicide ideation Weighing less than 100 lbs (45 kgs) History of Deep Brain Stimulation surgery Diagnosis of Dementia Taking certain types of medications may be an this will be reviewed with all potential participants Females that are pregnant, planning to become pregnant, or are breastfeeding will not be included in the study. Females of childbearing potential will need to verify that they are not pregnant by a negative urine pregnancy test | 2 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 50.0-999.0, Alzheimer's Disease for AD cases Diagnosis of probable AD, defined according to the criteria51 Light to moderate severity of the disease, defined by a MMSE score >10 (global evaluation of cognition) Patient aged 50 years or more Patient benefiting from social insurance for controls Absence of suspicion of dementia, based on normal performance according to age and educational level at neuropsychological testing defined as Free recall ≥17 and total recall ≥40 for the Free and Cued Selective Reminding Test (Grober and Buschke test 52) MMSE ≥ norm for age and educational level (defined by mean SD) Isaac's set test ≥ norm for age and educational level (defined by mean for all patients History of Parkinson's disease or other neurodegenerative disorder History of Horton's disease History of inflammatory neuropathies (in particular Devic's disease, multiple sclerosis) History of vascular ischemic neuropathies and chronic intracranial hypertension History of pituitary tumors Presence of diseases (systemic and/or ocular diseases) or behavioural or cognitive symptoms incompatible with eye examination Known diabetes Person under tutorship or curatorship, person unable to express consent Additional | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Differentiated Thyroid Cancer Age over 18 years Patient has thyroid cancer Patient is judged as being capable of understanding the information sheet and of giving informed consent (Mental Capacity Act 2005) Responsible clinician is approached and is happy for the patient to be included in the study Age of less than 18 years Patient has additional risk infections (HIV, Hep B/C) Patient is involved in other medicinal or treatment based clinical trial at the time of recruitment or in the previous 4 months | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Breast Cancer newly diagnosed breast cancer no metastasis detected operation for breast cancer female patient unilateral breast cancer informed consent given age min. 18 yrs metastasis of breast cancer bilateral breast cancer other cancer within the last 5yrs | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-55.0, Multiple Sclerosis, Relapsing-remitting Enrolled into the 2-year, double-blind, placebo-controlled ASA study and entered 3 year extension study MRI was performed on all patients using a 1.5 T magnet MRI images unable to be processed All 5 MRI time points not collected | 2 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 40.0-70.0, Arthrosis of the Knee The participants of the study are patients that have been scheduled for a primary TKA using the usual indications for TKA at the Department of Planned Elective Surgery Z, Gentofte Hospital Severe osteoarthrosis of the knee with indication for a TKA Age between 40 and 70 years Diseases affecting the bone metabolism (osteoporosis, Pagets disease, hyperparathyreoidism etc.) Patients estimated not to be able to understand the "Information to patients" papers or do not want to participate in the study | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-80.0, Knee Arthritis patients waiting for knee replacement neurologic disease | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 8.0-21.0, Brain Structural Connectivity Cognitive Function Ages 8-21 without current and past history of any psychiatric disorder and autistic symptoms Current symptoms or lifetime history of DSM-IV-TR diagnosis of attention-deficit/hyperactivity disorder, pervasive developmental disorder, schizophrenia, schizoaffective disorder, delusional disorder, other psychotic disorder, organic psychosis, bipolar disorder, depression, severe anxiety disorders or substance use With neurodegenerative disorder, epilepsy, involuntary movement disorder, congenital metabolic disorder, brain tumor, history of severe head trauma, and history of craniotomy With major systemic disease Full-scale IQ < 80 | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 65.0-89.0, Mild Cognitive Impairment Dementia Memory Disorders Age between 65 and 89 Successful completion of primary school MCI, as Mini Mental State Examination score between 20 and 27 and confirmation through neuropsychological examination by a specialist, according to current guidelines Moderate/severe dementia Clinical signs of depressive disorder or other primary psychiatric disorders Neoplastic diseases Neurologic or musculoskeletal deficits barring neuropsychological examination or physical or cognitive training Severe heart disease End stage renal disease (eGFR<35 ml/min(1.73 m2) Severe chronic obstructive pulmonary disease (COPD) and/or respiratory failure Complicated or decompensated diabetes Overt peripheral artery disease Any inability to successfully complete a brain magnetic resonance scan | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-90.0, Ischemic Stroke Involving Corticospinal Tract. Patients of 18 to 90 years old Subcortical stroke Achievement of the internal capsule, according to MRI Ability to perform MRI within 10 days after the onset of symptoms NIHSS over or equal 2 and < 20 Rankin Score over or equal 1 and ≤ 5 Written informed consent after information about the protocol, from patients or reliable person if patient is in incapacity to sign Affiliation to a social security scheme Pregnant or nursing women Other cerebral lesion, concomitant or preexisting Concomitant disease causing unfavorable prognosis within 3 months after pre-existing psychiatric illness Alcoholism or other chronic intoxication Cortical localization of the infarction Patient in a coma, who cannot be examined and evaluated Patient intubated, ventilated, sedated Cerebral hemorrhage, intra-parenchymal and / or subarachnoid Persons protected by law (guardianship, curators and judicial protection) | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 40.0-79.0, Lower Limb Spasticity After Stroke patients with lower limb spasticity after stroke duration more than 6 months Modified Ashworth Scale of ankle joint more than 2 patients with previous botulinum toxin injections to lower limbs patients with serious hepatic, renal or cardiac dysfunction patients with respiratory failure patients who cannot understand the instructions | 1 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 0.0-999.0, Breast Neoplasms Newly diagnosis of breast cancer for which surgical intervention is planned patients received neoadjuvant chemotherapy before breast surgery | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 30.0-999.0, Atrial Fibrillation Heart Failure Stroke Myocardial Infarction Patients with a coded diagnosis for atrial fibrillation in their primary or secondary care record Patients in GPRD practices which are deemed "up to standard" by GPRD Patients whose records are deemed "acceptable" by GPRD and contain at least one year of data Patients whose age and sex, as recorded in GPRD is the same as that recorded in HES A diagnosis of heart failure, stroke, or myocardial infarction occurring before diagnosis of atrial fibrillation | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 65.0-85.0, Disturbance; Balance, Labyrinth Parkinson´s Disease Elderly The patient is able to provide informed consent Definitive Idiopathic Parkinson's Disease as diagnosed by a Neurologist Hoehn and Yahr Stage 1-3 Able to ambulate without an assistive device On stable doses of Parkinson's medications prior to study onset Mini Mental Status Exam (MMSE) < 24 Change in Parkinson's medications in the duration of study Uncontrolled orthostasis Symptomatic coronary artery disease Fracture of lower limb prior to study onset Other neurologic diagnosis Physical therapy before and during to study duration Significant camptocormia Any medical condition which the physician investigator determines would compromise the safety of exercise program for the subject | 1 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 50.0-999.0, Sleep Disordered Breathing Alzheimer's Disease Male and female subjects with normal cognition and >50 years of age will be enrolled. Younger subjects are not included as the risk for cognitive impairment is too low. Moreover, by selecting this age-range we minimize the possibility of including early-onset genetic forms of neurodegenerative diseases such as Alzheimer's disease and Frontotemporal Dementia Normal subjects will be within normal limits on neurological and psychiatric examinations. All subjects enrolled will have both a Clinical Dementia Rating = 0 and Global Deterioration Scale < 3 All subjects will have had a minimum of 12 years education.The education restriction reduces performance variance on cognitive test measures and improves the sensitivity for detecting pathology and disease progression using the robust norms available at NYU School of Medicine All subjects will have an informed family member or life partner interviewed to confirm the reliability of the subject interview. All subjects will agree to the MRI imaging, the lumbar puncture, apolipoprotein E (ApoE) genotyping and DNA banking Diagnosis of any brain disease or MRI evidence of brain damage including significant trauma, hydrocephalus, seizures, mental retardation or other serious neurological disorder (e.g. Parkinson's disease or other movement disorders). Persons with silent cortical infarcts are excluded. Subcortical infarcts and white matter lesions are not exclusions History of brain tumor Any radiation or chemotherapy anywhere in the body in the past 3-years Significant history of alcoholism or drug abuse History of psychiatric illness (e.g., schizophrenia, mania, PTSD, or life long history of major depression) Hamilton Depression Scale >16 only with history of life long depressive episodes. Otherwise not excluded Evidence of clinically relevant and uncontrolled cardiac, pulmonary, or hypothyroid or hematological conditions. Insulin dependent diabetes and/or history or treated hypertension are not an exclusion. Normal subjects with current levels of HbA1c >5.9% or diabetics >7.0% (American Diabetes Association, 2010) and/or current blood pressure levels >140/90 mm Hg (JNC on Prevention, Detection, Evaluation and Treatment of High Blood Pressure, 2003) will be advised to seek referral Physical impairment of such severity as to adversely affect the validity of psychological testing Hostility or refusal to cooperate Any prosthetic devices (e.g., pacemaker or surgical clips) that constitutes a hazard for MRI imaging | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 2.0-17.0, Cerebral Palsy Spasticity Female or male subject of 2 to 17 years of age (inclusive) Uni or bilateral Cerebral Palsy (CP) with clinical need for injections with NT 201 for the treatment of upper limb (UL) spasticity at least unilaterally Ashworth Scale (AS) score in the main clinical target patterns in this study Flexed elbow: AS≥2 in elbow flexors (at least unilaterally). and/or Flexed Wrist: AS≥2 in wrist flexors (at least unilaterally) Clinical need according to the judgment of the investigator in one out of five treatment combinations (A-E, as shown below). AS score must be ≥2 for each target pattern chosen for injection at the Baseline Injection Visit V2 A. UL(s) treatment only (GMFCS I-V) A1) Unilateral treatment of UL spasticity with 8 U/kg BW NT 201 (maximum of 200 U) for At least one of the main clinical target patterns flexed elbow (4 U/kg BW) and/or flexed wrist (2 U/kg BW) Pre-treated (non-naïve) subjects must not have received BoNT treatment within the last 16 weeks prior to study treatment at V2 in any indication | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Lower Limb Spasticity Men or women age 18 years and above Post-stroke lower-limb spasticity Prior agreement with the patient to inject BoNT-A If previously treated with BoNT-A, (at least 3 months interval between last injection and inclusion) Therapeutic goals agreed jointly with the patient Functional Ambulation Classification (FAC) score 2-5 Capacity to comply with the protocol Written informed consent Documented positive antigenicity to botulinum toxin Neuromuscular disease Use of medications that interfere with neuromuscular transmission Severe muscle atrophy in any muscle to be injected Any other indication that might interfere with rehabilitation or the evaluation of results Any non-stroke spasticity diagnosis Pregnancy or nursing mothers Previous participation in any study using Goal Attainment Scale (GAS) | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 65.0-999.0, Postoperative Cognitive Dysfunction Delirium Dementia Age ≥ 65 years Elective major surgery Planned general anesthesia Cardiac surgery Neurosurgery including carotid endarterectomy Preoperative Mini Mental State (MMS) Examination Score < 24 Previous pathological neuroimaging (if available) History of cerebral or cerebrovascular pathology Chronic use of psychiatric medication Alcohol or substance abuse A history of chronic pain unrelated to the planned surgery Any contraindication for MRI (e.g. pacemakers and other MR-incompatible metal implants) Claustrophobia | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Induced Pluripotent Stem Cells OR THIRD PARTY (ALLOGENEIC CELLS, AND Subjects who meet ALL of the following will be considered for enrollment into this study Be greater than or equal to 18 years of age, as of the date of enrollment. There is no upper age limit for donor enrollment Able to provide informed consent Meets the donation requirements established by AABB and FDA for allogeneic or autologous use with the exception of hemoglobin/hematocrit Subjects who meet ANY of the following will be excluded from participation in this study as a third party donor or research volunteer Medical history that includes any of the following, as per AABB or FDA requirements for allogeneic use Thrombocytopenia or other blood dyscrasias Bleeding diathesis Antibiotic use within the prior 48 hours History of cancer History of exposure to transfusion transmitted diseases including HIV and hepatitis B and C as defined by the Standards for Blood Banking and Transfusion Services, AABB Travel to an area where malaria is endemic as defined by the CDC (www.cdc.gov/travel) At risk for the possible transmission of Creutzfeldt-Jakob Disease (CJD) and Variant Creutzfeldt-Jakob Disease (vCJD) as described in the FDA Guidance for Industry, January 9, 2002, Revised Preventive Measures to Reduce the Possible Risk of Transfusion of Creutzfeldt-Jakob Disease (CJD) and Variant Creutzfeldt-Jakob Disease (vCJD) by Blood and Blood Products Febr le (temperature > 38 (Infinite)C) | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Gaucher Disease Type 1 Age: >18 Gaucher disease type 1 Able to undergo a DEXA test Minors | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Amyotrophic Lateral Sclerosis (ALS) Patients ≥18 years of age, diagnosed with ALS (<2 months before inclusion) according to Airlie House : definite, probable, or probable laboratory supported Time between first symptoms and diagnosis less than 18 months Sporadic or familial cases Patient agreement to be followed in a given ALS centre during the duration of the study Patients with a loss of at least 1 point in 3 items of the rating scale or with a loss of at least 2 points in 2 items of the rating scale Patients who signed the informed consent form Associated dementia or inability to understand the requirements of the protocol No helper ONS already begun Artificial nutrition: enteral or parenteral nutrition Known hypersensitivity to components of ONS Absence of treatment with Riluzole (RILUTEK®) Patient under guardianship or curatorship Participation in another research protocol | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 30.0-75.0, Stroke Paresis Motor deficits of the upper limb after a first ever stroke A minimum punctuation of 11 in the subtest from the Motricity Index and Trunk Control Test which evaluates grip and pinch Less than 6 months from stroke Age between 30 and 75 years Right-handed Inability to speak and understand the Spanish or Catalan language Major cognitive impairment affecting comprehension Neurological or psychiatric co-morbidity Substance abuse Formal musical education (i.e. professional musicians) Metallic implants incompatible with neuroimaging assessment Withdrawal from the study Voluntary withdrawal of consent A new episode of stroke during the participation in the study | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 0.0-999.0, Dementia Paratonia Severe cognitive impairment (complete dependency in all activities of daily living (ADLs) Diagnosis of Alzheimer's disease, vascular dementia,or frontotemporal dementia Score> 3 on the paratonic assessment instrument, with paratonic rigidity in an arm(s) interfering in the provision of care Alternate etiologies for increased tone Botulinum toxin 6 months preceding the study | 1 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-80.0, Spasticity Men and women ≥ 18-80 years Poststroke limb spasticity Patients who have suffered a stroke in the previous 6 months Treatment goal has been previously agreed with the patient or their legal representative Patients with clinically significant poststroke upper/lower limb spasticity, in whom it has been decided to perform multidisciplinary treatment with BoNT-A + rehabilitation No previous treatment with BoNT-A Patient is able to follow the protocol Written informed consent Neuromuscular disease Use of drugs that interfere with neuromuscular transmission Any other condition that could interfere with rehabilitation or evaluation of the results Diagnosis of spasticity not associated with stroke Pregnant or nursing mothers Prior participation in any other study in the 6 months before study entry | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 65.0-999.0, Major Depressive Disorder Current DSM-IV diagnosis of MDD, unipolar type, without psychotic features and 6 weeks minimum duration of current depressive episode Moderate severity of depression using the Hamilton Depression Rating Scale (HDRS > 20) English speaking, male or female 65 years of age or older Good general health Able to give informed consent Antidepressant use or psychotherapy within the past 6 weeks or electroconvulsive therapy within the past 6 months Recent history (<6 months) of substance or alcohol abuse or dependence (DSM-IV criteria) Use of cognitive enhancing medications Current diagnosis of Post-Traumatic Stress Disorder or other Axis 1 psychiatric disorder Neurological diseases (e.g., Parkinson's disease, epilepsy, cortical stroke, Alzheimer's disease, traumatic brain injury) or dementia History of surgical procedures affecting study outcomes Contraindications for MR exam, i.e., no claustrophobia, no paramagnetic metal implants, able to fit in the MRI machine comfortably (BMI ≤ 38) Acute or uncontrolled medical illness or medication use impacting cognitive function | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Parkinson's Disease Idiopathic Parkinson's Disease with bradykinesia and at least two of the following signs; resting tremor, rigidity, and asymmetry Despite optimal pharmacological treatment, at least one of the following symptoms: severe response fluctuations, dyskinesias, painful dystonia or bradykinesia A life expectancy of at least two years Age below 18 years Previous PD-neurosurgery (e.g., DBS, pallidotomy, thalamotomy) Previous CLI (through a PEG-tube or Nasal Jejuna| tube) Hoehn and Yahr stage 5 at the best moment during the day Other severely disabling disease Dementia or signs of severe cognitive impairment Psychosis Current depression Contraindications for DBS surgery, such as a physical disorder making surgery hazardous Contraindications for PEG surgery such as interposed organs, ascites and oesophagogastric varices, or for Duodopa | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Leukoencephalopathy diagnosis of glioma (stage 3 to 4) both genders age > 18 years treatment by radiotherapy and chemotherapy clinical monitoring post radiotherapy in Neurology Department, Pitié-Salpêtrière University Hospital and in the radiotherapy department of the Paul Strauss Institute other neurological tumors and brain metastases psychiatric severe illness, including severe depression | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 35.0-999.0, HIV - Human Immunodeficiency Virus Cognitive Impairment age 35 years or older HIV infection for at least 1 year able to communicate in English or French capable of providing informed consent easy access to the internet EEG and MRI compatible presence of dementia life expectancy < 3 y other neurological disorder including active opportunistic CNS infection psychotic disorder current substance dependence or abuse; and Hepatitis C requiring interferon therapy during the study period | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-999.0, Cancer Rectal Cancer High-risk patients with biopsy proven rectal adenocarcinoma who will undergo long-course chemoradiotherapy (CRT) and who are potentially eligible for curative surgery Patients who have persistently (i.e. in baseline and post-treatment MRI) mrEMVI positive (with superior rectal vein invasion) or mrEMVI negative tumours Patients aged over 18 years Negative (on CT) for metastatic disease Under 18 years of age Patients with any metastatic disease Patients with a synchronous second malignancy | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-55.0, Multiple Sclerosis 55 inclusive years of age at the time of informed consent Diagnosis of relapsing multiple sclerosis as defined by the 2010 revised McDonald Currently taking Tysabri Systemic steroid users comorbidities that could confound MRI outcomes | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 35.0-75.0, Parkinson Disease Dementia Age at the time of enrollment: 35 years Diagnosis of idiopathic PD with probable Parkinson's disease dementia (PDD) as defined by the MDS consensus guidelines (Emre et al., 2007) Mild to moderately severe dementia as defined by a Mini-Mental State Examination (MMSE) score of 10 to 24 Duration of bilateral idiopathic PD: ≥5 years of motor symptoms Severity of bilateral idiopathic PD in the meds off state: modified Hoehn and Yahr stage ≥2 UPDRS subset III score of ≥30 in the meds off, stim off state Levodopa must improve PD symptoms by ≥30% in a levodopa challenge test, as measured by UPDRS subset III score PDD with a symptom onset at least 2 years after first symptoms of PD Be willing and able to comply with all visits and study related procedures (e.g., using the remote control, charging systems and completing the motor diary) if mentally competent or, if incompetent, their legally authorized representatives Any significant psychiatric problems, including acute confusional state (delirium), ongoing psychosis, or clinically significant depression Any current drug or alcohol abuse Any history of recurrent or unprovoked seizures Any prior movement disorder treatments that involved intracranial surgery or device implantation A history of neurostimulation intolerance in any area of the body Any significant medical condition that is likely to interfere with study procedures or likely to confound evaluation of study endpoints, including any terminal illness with survival <12 months Participation in another drug, device, or biologics trial concurrently or within the preceding 30 days. Any other trial participation should be approved by the Principal Investigators Pregnancy, breast-feeding, or lack of reliable contraception | 0 |
A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower extremities. Neurologic examination confirms severe cognitive deficits and memory dysfunction. An electroencephalogram shows generalized periodic sharp waves. Neuroimaging studies show moderately advanced cerebral atrophy. A cortical biopsy shows diffuse vacuolar changes of the gray matter with reactive astrocytosis but no inflammatory infiltration. | eligible ages (years): 18.0-80.0, Hereditary Spastic Paraplegia Age between 18 and 80 years Clinical diagnosis of Hereditary Spastic Paraplegia Ability to walk at least 10 meters: Assistive devices are permitted Wheelchair bound patients Additional neurological symptoms that may significantly impact gait such as ataxia, polyneuropathy or dementia Fixed tendon contractures Antecedents of allergy or adverse reaction to botulinum toxin Pregnancy or breastfeeding condition Mental retardation Dementia | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 45.0-80.0, Colon Cancer Polyps Patients who are 45 to 80 years old for routine screening colonoscopy Patients with inflammatory bowel disease Patients with polyposis syndromes Pregnant women Patients over 350 pounds Patients with bright red blood per rectum Patients who have a contraindication to undergo outpatient colonoscopy, including patients on blood thinners, prior myocardial infarction (MI) in the last six months, history of congestive heart failure (CHF), history of arrhythmia, patients too weak to transfer themselves from a bed to a chair, or patients with severe constipation who would require a two day bowel preparation All subjects will undergo informed consent by the St. Luke’s institutional review board (IRB). Referred subjects will be asked if they are interested in the study and those responding affirmatively will be transferred to a recruiter to learn about the study and begin the consent process if interested | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Polyps Patients: over 18 years of age, with clinical indication for colonoscopy who are considered by the endoscopist to be fit for the procedure Endoscopists who have started colonoscopy training on a recognised training rotation. Consultants who perform colonoscopy regularly patients under 18 years, patients with previous colorectal surgery or known familial polyposis, patients unable to give informed consent, pregnant patients, patients for whom coloscope insertion was difficult or uncomfortable, patients whose colon is not sufficiently cleared of stool, those unwilling to participate | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Colorectal Neoplasms Metastatic colorectal cancer Histologically or cytologically proven colorectal cancer Measurable disease on CT scan with at least one lesion >/= 2cm diameter (to allow adequate scout infusion imaging) Expected survival of at least 4 months ECOG performance status 0-2 Vital laboratory parameters should be within normal range including Neutrophils >/= 1.5 x 10^9/L Platelets >/= 150 x 10^9/L Serum bilirubin </= 34 micromol/L calculated creatinine clearance > 50 ml/min Previous treatment with capecitabine Untreated active metastatic disease to the central nervous system (new or enlarging lesions on CT or MRI), or within 3 months of treatment (ie surgery or radiotherapy) for brain metastases Other serious illnesses, eg, serious infections requiring antibiotics, bleeding disorders Liver involvement with metastatic disease > 50% liver volume Chemotherapy, radiation therapy, or immunotherapy within 4 weeks before study entry (6 weeks for nitrosoureas) Previous external beam irradiation except if: (i) it was for standard adjuvant pelvic radiation for rectal cancer; (ii) it was for localised irradiation for skin cancer; or (iii) the sum total of all previous external beam irradiation port areas is not greater than 25% of the total red marrow Previous treatment with a monoclonal antibody or antibody fragment AND a positive huA33 HAHA titre Concomitant treatment with systemic corticosteroids. Topical or inhalational corticosteroids are permitted Mental impairment that may compromise the ability to give informed consent and comply with the requirements of the study Lack of availability of the patient for clinical and laboratory follow-up assessment | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Skin Cancer Male or Female and over 18 years of age Patients undergoing an examination of their skin Patients with a lesion(s) in one of the five categories: basal cell carcinoma, squamous cell carcinoma, pre-cancer lesions, pigmented lesions, and benign lesions Patients whose lesion also warrants a biopsy Signed informed consent document Patients with absence of skin lesion(s) in one of the five categories Patients whose identified lesion did not need a biopsy Patients who did not sign the informed consent and agree to participate | 2 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 0.0-999.0, Skin Rash receiving bone marrow transplant - not receiving other growth factors | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 45.0-999.0, Venous Insufficiency Aged 45 years and older CEAP classification: stage C4 (changes in skin and subcutaneous tissue secondary to CVDs)4a (pigmentation or eczema) 4b (lipodermatosclerosis or atrophie blanche) C5 (healed venous ulcers) Ankle brachial index (ABI) 0.9 3mm Hg 0 absence of peripheral arterial disease Intact skin sensation measured with 10 gram monofilament Intact thermal sensation measured with thermal sensory tester at lower leg skin and foot surfaces Agreement to wear compression garments such as wraps or stockings during waking hours Phone, e-mail, or mail accessible Working freezer ABI < 0.8 mm Hg or > 1.3 mm Hg -presence of lower extremity arterial disease (reduces skin temperature) Active systemic or localized infections such as cellulitis (raises skin temperature) Autoimmune disorders that reduce blood flow such as Raynaud's phenomenon Body temperature > 37.6 degrees C (febrile state raises skin temperature) CEAP classification c6: active venous ulcer (cooling ulcerated skin might impair healing) Known peroneal nerve injury Impaired skin sensation Unable to detect light touch measured with a 10 gram monofilament at lower leg skin surfaces Unable to detect not/cold sensation measured with thermal sensory tester at lower leg skin surfaces Not wearing compression or not agreeing to wear compression wraps or stockings | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 5.0-10.0, Molluscum Contagiosum, Skin Disease Anyone aged 5-10 years with the clinical diagnosis of molluscum contagiosum Anyone with immunosuppression including HIV or previous organ transplantation Anyone taking immunosuppressive medications Anyone who has previously received treatment with cantharidin Any female who has had her first menstrual period | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Carcinoma, Advanced Metastatic Histologically confirmed advanced or metastatic non-curable solid tumor (if limited to a single lesion and not a candidate for curative surgery or radiation therapy) Completed ≥1 conventional therapy Clinically indicated surgery or procedure to collect available tumor in sufficient quantity ("golf ball size," pleural or ascites fluid may also be collected) for vaccine processing Subjects that have completed all acceptable therapies that are the current standard of care for their respective diseases Recovered from all toxicities related to prior therapies Subjects with brain metastases treated at least ≥2 months prior to enrollment, without related clinical symptoms and must have a stable neurological exam on the screening evaluation ≥1 measurable or evaluable lesion Age ≥18 years ECOG performance status (PS) 0-1 Normal organ and marrow function Surgery involving general anesthesia, chemotherapy, radiotherapy, steroid therapy, or immunotherapy within 4 weeks prior to entering the study Patient must not have received any other investigational agents within 30 days prior to study entry Patients with known brain metastases unless treated and stable for ≥2 months Patients with mucinous adenocarcinoma Short term (<30 days) concurrent systemic steroids ≤ 0.125 mg/kg prednisone per day (maximum 10 mg/day) and bronchodilators (inhaled steroids) are permitted; other steroid regimens and/or immunosuppressives are excluded. Patients requiring steroids following previous CNS radiation for metastatic disease are excluded Prior splenectomy Prior malignancy (excluding nonmelanoma carcinomas of the skin) unless in remission for ≥2 years Kaposi's Sarcoma Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements Patients who are pregnant or nursing | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Effects of Chemotherapy patients receiving docetaxel as mono or combination therapy patients with no nail disorders at the start of treatment life expectancy of at least 3 months patients previously treated with taxane chemotherapy Raynaud's phenomenon distal metastases ungual pathology arteriopathy cold intolerance peripheral neuropathy of grade 2 or higher patients currently enrolled in clinical trials | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Melanoma Patients or volunteers with or without a history of melanoma One or more palpable skin or subcutaneous lesions for which at least one of the following is true A tissue diagnosis has been made for the lesion(s) in question, by prior cytologic or histologic evaluation (Category A1) A tissue diagnosis will be obtained for the lesion(s) in question by cytologic or histologic evaluation (Category A2) A tissue diagnosis is not available, but a clinical diagnosis of melanoma or benign lesion is available with a high degree of confidence. Examples are hemangiomas, skin tags, seborrheic keratoses, dermatofibromas, lipomas, or growing pigmented skin lesions that are comparable to other cutaneous metastases of melanoma in the same patient (Category B) All patients must have the ability and willingness to give informed consent and must be age 18 years or older at the time of study entry Known or suspected allergy to the adhesive skin markers or water-soluble ink used for the labeling of lesions Very fragile skin that may be susceptible to injury from adhesive markers Patients in whom there is a medical contraindication or potential problem in complying with the requirements of the protocol, in the opinion of the investigator | 1 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Skin Cancer Men and women over the age of 18 Skin lesion suspected to either BCC or SCC etc Patient was referred for biopsy diagnostic/therapeutic before hand, and regardless of confocal microscope examination, according to the clinical consideration of physician Pregnant women Children | 1 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-75.0, Basal Cell Carcinoma Study subjects must have had diagnosed at least one benign or malignant skin lesion Subject is from 18-75 years of age, inclusive Subject must sign and date all informed consent statements Subject is exhibiting signs of a bacterial or viral infection, including fever Subject is unwilling to allow a biopsy of a malignant lesion for histological analysis | 2 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, RECTAL NEOPLASMS Diagnosed with a large non-pedunculated rectal adenoma (sessile or flat) with a largest diameter of ≥2 cm (estimated by an opened resection snare of 20 or 30 mm) The lower and upper borders of the adenoma are located at ≥2 cm and ≤15 cm from the anal verge, respectively Biopsies of the lesion did not show malignant neoplastic tissue on histopathological evaluation; only lesions with low or high grade dysplasia are suitable for inclusion During flexible video endoscopy there are no signs of endoscopic suspicion for submucosal invasive cancer (Kudo pit pattern type V; excavated/depressed type morphology; fold convergence; or large smooth nodule >1 cm in a flat lesion) (33). In case of doubt, patients will undergo EUS as described at (2) In case doubt remains after flexible video endoscopy, endoscopic ultrasonography (EUS) of the rectal adenoma should invasion into the submucosal layer and pathological lymphadenopathy (lymph nodes >1 cm). When pathological lymph nodes are present, fine needle aspiration will be performed to lymph node metastasis (N+ disease) If not performed already, total colonoscopy will be done to detect and remove all synchronous colonic adenomas or cancers first. Cecal intubation must be confirmed by identification of the appendiceal orifice and ileocecal valve The general health condition of the patient permits general anesthesia (ASA classification I-III) Absence of non-correctable coagulopathy (international normalized ratio >1,5, or platelet count <90 × 109/l) Patient age of 18 years or older Preoperative histologically detected malignancy Previous anorectal surgery Contraindications to general anaesthesia | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 0.0-2.0, Hemangioma Patients with ages up to 2 years Clinically diagnosed hemangioma, in proliferative or involutive phase, with relative indication for clinical treatment, as itemized lesion causing alteration of regional anatomy with no systemic or functional damage and with a diameter greater than 1 centimeter, or lesion causing aesthetic deformity, or lesion causing local repetitive complications such as ulceration, bleeding or local infection, or lesion causing partial damage of orifices, or lesion causing psychological compromise Absence of cardiopathy (normal physical examination, anamnesis, echocardiography, electrocardiography and thoracic radiography) Informed consent signed by responsible parties Hemangioma with absolute indication for treatment, presenting a risk to function or life Patients with previous treatment for infantile hemangiomas Cardiac disease Pulmonary disease (asthma, bronchiolitis,bronchopulmonary dysplasias) Raynaud syndrome Pheochromocytoma Altered echocardiography, even if asymptomatic | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 11.0-999.0, Acanthosis Nigricans Hyperinsulinemia Spectroscopic Analysis Subjects must have an elevated fasting insulin level, suggesting they are in an insulin resistant state Subjects must carry a diagnosis of acanthosis nigricans, which will be verified by a Dermatologist before entry into the study. If necessary, a small 4mm punch biopsy may be taken to document dermatopathology consistent with acanthosis nigricans Subjects must be willing and able to undergo treatment with Metformin, including initial referral and follow up Agree to abide by the investigator's guidelines Be able to understand the requirements of the study, the risks involved and are able to sign the informed consent form Agree to follow and undergo all study-related procedures Subjects with Type 1 Diabetes are excluded because of their naturally insulin-deficient, rather than hyper-insulinemic, states Women who are lactating, pregnant, or planning to become pregnant Any reason the investigator feels the patient should not participate in the study | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Benign and Malignant Skin Neoplasms Patients with skin lesions undergoing biopsy for diagnosis Patients with skin lesions which do not require biopsy for diagnosis | 2 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 20.0-85.0, Lymphadenopathy Malignancy Patients with malignant cervical lymphadenopathie With US-FNA or US-CNB evaluation before No ultrasound exam | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-45.0, Infant and Young Child Feeding Mothers with healthy children between 6 and 24 mo | 1 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 0.0-999.0, Colonic Polyp Patients with pedunculated colorectal polyps, the heads of which were larger than 10mm and the stalk of which were large than 5 mm in diameter, were included bleeding tendency poor preparation sessile polyp | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Actinic Keratosis Male or female, age 18 years or older being seen in a dermatology clinic Informed consent of participation must be given by subject Inability to complete all study questionnaires Subjects who are unable to read and write English | 2 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 20.0-35.0, Acne Vulgaris Have Acne vulgaris, presenting at least inflammatory lesion on the face Body mass index between 18.0 and 30.0 kg/m2 (inclusive), and body weight not less than 50 kg (man) or 45 kg (woman) Blood pressure between 90 and 140 mmHg systolic (inclusive), and no higher than 90 mmHg diastolic Electrocardiogram (ECG) consistent with normal cardiac conduction and function Non-smoker Adequate contraception method for both men and women. If a woman, must have a negative pregnancy test Signed an informed consent document History of or current clinically significant medical illness that the investigator considers should the participant or that could interfere with the interpretation of the study results Clinically significant abnormal values for hematology, biochemistry or urinalysis Clinically significant abnormal physical examination, vital signs or ECG Use of any prescription or nonprescription medication within 14 days before the study treatment History of drug or alcohol abuse within the past 5 years Drug allergy or drug hypersensitivity Blood donation, depending on the volume of blood collection Positive test for human immunodeficiency virus (HIV), hepatitis B or C, or syphilis Dermatological disease at application site Photosensitivity | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 21.0-999.0, Venous Disease Venous Vascular Diseases and Syndromes Venous Insufficiency Venous Ulcers aged 21 years or older CEAP Classification: Stage C4 (skin damage) and 5 (healed VLU) leg ulcer healed within past month with intact epithelium history of healed VLU within past 2 years ankle brachial index (ABI) 0.80 3 mmHG, absence of peripheral arterial disease intact skin sensation intact thermal sensation agreement to ear compression during waking hours phone, email or mail accessible diagnosed arterial disease or ABI <0.80 or >1.3 mm Hg (blood flow to the skin is reduced in arterial disease and cooling could cause tissue ischemia) surgical procedures on leg in past 1 year (can affect venous circulation/cause edema) open leg/foot ulcers recent leg infection within past month (increased inflammation) impaired cognitive status (cannot perform procedures) chronic inflammatory and vascular conditions where blood flow of the skin may be impacted such as Lupus erythematosus, lymphedema, Raynaud's, rheumatoid arthritis, scleroderma, end stage renal disease, chronic obstructive pulmonary disease, chronic regional pain syndrome, multiple sclerosis, hypersensitivity to cold, or patients on chemotherapy | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Actinic Keratosis Subjects must be competent to understand the nature of the trial and provide informed consent Subjects with 4 to 8 clinically typical, visible and discrete AKs within a contiguous 25 cm2 treatment area on the face or scalp Subject at least 18 years of age Female subjects must be of either Non-childbearing potential, i.e. post-menopausal or have a confirmed clinical history of sterility (e.g. the subject is without a uterus) or Childbearing potential, provided there is a confirmed negative urine pregnancy test prior to study treatment, to rule out pregnancy Female subjects of childbearing potential must be willing to use effective contraception Location of the selected treatment area on any location other than the face or scalp within 5 cm of an incompletely healed wound within 10 cm of a suspected basal cell carcinoma (BCC) or SCC Prior treatment with PEP005 Gel on face or scalp Selected treatment area lesions that have atypical clinical appearance and/or recalcitrant disease History or evidence of skin conditions other than the trial indication that would interfere with evaluation of the trial medication Clinical diagnosis/history or evidence of any medical condition that would expose a subject to an undue risk of a significant AE or interfere with assessments of safety and efficacy | 1 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Postpolypectomy Bleeding Patients with one or more pedunculated polyps, the heads of which measured more than 1cm (regardless of the stalk thickness and length), and they were compared against the size of the biopsy forceps (6mm) and subsequently confirmed in the anatomical specimen Not to have any hemostatic alterations at the time the endoscopy was performed (confirmed by the usual blood tests taken before the procedure) Patients younger than 18 years of age Patients with a platelet count of less than 50000, INR larger than 1.5 Patients who refused to give their informed consent | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-50.0, Non-palpable Breast Lesions Have had stereotactic or ultrasound-guided biopsy with marker placement Have a lesion or biopsy marker that is visible under ultrasound Have surgical target < 6 cm from the skin when lying supine Have a discreet surgical target Have a lesion in which the center/focal area is defined Be at least 18 years of age or older Have a palpable lesion that does not require localization Require more than one localization needle for localization of the surgical target Have undergone previous open surgical biopsy or lumpectomy in the operative breast Have an implant in the operative breast Have a cardiac pacemaker or defibrillator device | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 60.0-999.0, Basal Cell Carcinoma (BCC) Patients over 60 years old BCC was determined with tissue diagnosis in the lower extremity One or more risk factor for surgical complication including: diabetes, venous insufficiency, obesity, peripheral vascular disease, lymphedema and long term steroids use Patient unable to read, understand and sign the consent form | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Wide-neck, Saccular Intracranial Aneurysms At least 18 years old A wide-neck intracranial saccular aneurysm with a neck ≥ 4mm or a dome to neck ratio <2 in the ICA from the cavernous segment to the carotid terminus (including the paraclinoid, ophthalmic, hypophyseal and posterior communicating segments) Life expectancy > 12 months Signed Informed Consent Females who are pregnant or intend to become pregnant during the study. (Females of child-bearing potential must have a urinary pregnancy test within 7 days of enrollment) Extradural aneurysms Known multiple untreated cerebral aneurysms at study entry Recent history of subarachnoid hemorrhage, intracranial hemorrhage, or major surgery within one month of enrollment Admission platelet <50,000 or any known hemorrhagic diathesis, coagulation deficiency, or on oral anticoagulant therapy with an INR >3.0 Contraindication to angiography such as elevated creatinine or known allergy to angiographic contrast Contraindication to CT and/or MRI scans Known allergy to the metal component of the Penumbra Liberty Stent System Evidence of active infection (WBC >10x109 /L) Any medical conditions that will not allow the necessary follow-up for this study (e.g., pre-existing neurological or psychiatric diseases) | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-999.0, Non-melanocytic Skin Tumors Melanocytic Skin Tumors seborrhoeic warts nevi dermatofibroma basal cell carcinoma actinic keratosis squamous cell carcinoma Bowen's disease Merkel cell carcinoma malignant melanoma employers of the Medical University of Vienna patients during compulsory military service patients with an appointed guardian | 2 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 0.0-999.0, Clinically Atypical Pigmented Skin Lesion Cutaneous lesions examined with MelaFind must satisfy all of the following The lesion is pigmented (i.e., melanin, keratin, blood) The diameter of the pigmented area is not < 2 mm, and not > 22 mm The lesion is accessible to the MelaFind The patient, or a legally authorized representative, has consented to participate in the study and has signed the Informed Consent Form Cutaneous lesions that meet any of the following will not be accepted The patient has a known allergy to isopropyl alcohol The lesion has been previously biopsied, excised, or traumatized The skin is not intact (e.g., open sores, ulcers, bleeding) The lesion is within 1 cm of the eye The lesion is on mucosal surfaces (e.g., lips, genitals) The lesion is on palmar hands The lesion is on plantar feet The lesion is on or under nails The lesion is located on or in an area of visible scarring | 1 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-80.0, Colorectal Polyp pedunculated colorectal polyps larger than 2cm in diameter long-term antiplatelet therapy presence of intraepithelial | 0 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 18.0-79.0, Body Temperature Changes belong to ethnic groups requested suffering any change in skin sensitivity, illness of an infectious nature or previously diagnosed diseases that respond negatively to the use of cold | 1 |
A 43-year-old woman visits her dermatologist for lesions on her neck. On examination, multiple lesions are seen. Each lesion is small soft, and pedunculated. The largest lesion is about 4 mm in diameter. The color of different lesions varies from flesh colored to slightly hyperpigmented. | eligible ages (years): 10.0-999.0, Keloid Cicatrix, Hypertrophic Keloids, defined as excessive scar tissue raised above skin level and proliferating beyond the confines of the original lesion Hypertrophic scars1 older than 12 months and insensitive to other treatments. Keloids were distinguished from hypertrophic scars based on the clinical judgment of experienced plastic surgeons and on the age of the scar (>1yr) A period between previous treatment and IL cryotherapy covered a minimum of 12 weeks Patients with all Fitzpatrick17 skin types Patients older than 10 years of age pregnancy diabetes mellitus | 0 |
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