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A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Cerebrovascular Diseases Ischemic Stroke Repository All patients diagnosed with cerebral vascular disease, regardless of gender, age, ethnicity/race, stage of disease or treatment, are eligible Expected availability of clinical follow up data Participants must be willing to provide written, informed consent obtained in accordance with institutional and federal guidelines Pregnant women are excluded from the study | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Intracerebral Hemorrhage Arterio-venous Malformation All patients with ICH associated AVMs and a modified Rankin Scale <2 (so 0-1) before hemorrhage Pretreatment (embolization, radiosurgery, surgery) before ICH is not an criteria incomplete data set AVM Patients with only SAH or IVH and no ICH | 1 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Diabetes Individuals with baseline period of 183 days with continuous medical and pharmacy coverage preceding the first prescription fill new and current users of the following exposures Long-acting insulin (insulin detemir, glargine) alone or with metformin (LAI) Long-acting insulin (insulin detemir, glargine) plus rapid/short acting insulin (with or without metformin) (LAI+R) Long-acting insulin (insulin detemir, glargine) plus second-generation sulfonylurea agent (Glimepiride, Glipizide, Glipizide/Metformin, Glyburide, Glyburide/Metformin) (with or without metformin) (LAI+sulfa) NPH insulin (Humulin, Novolin) alone or with metformin (NPH) NPH insulin (Humulin, Novolin) plus rapid/short acting insulin (with or without metformin) (NHP+R) NPH insulin (Humulin, Novolin) plus second-generation sulfonylurea agent (Glimepiride, Glipizide, Glipizide/Metformin, Glyburide, Glyburide/Metformin (with or without metformin) (NPH + sulfa) Adult patients with diabetes with health insurance evidence of insulin pumps and/ or insulin pump supplies, gestational diabetes, liver disorders, dialysis, end-stage renal disease (ESRD), amputations, hemoglobinopathy, hemolytic anemia, or sickle cell anemia or transfusion Emergency Department (ED) visit for hypoglycemia; hospitalization or ED visit for cardiovascular event (stroke, acute myocardial infarction, unstable angina or diagnosis consistent with unstable angina - i.e., occlusion without infarction or coronary insufficiency) Adult patients with diabetes on any other insulins except cohort insulins (i.e., rapid/short unless in combinations above).* Adult patients with diabetes on first-generation sulfonylureas, Dipeptidyl peptidase-4 (DPP4), Glucagon-like Peptide (GLP), Sodium-glucose cotransporter-2 (SGLT-2) or Thiazolidinediones (TZD) agents, alone or in combination with cohort defining drugs* First generation sulfonylurea agents (chlorpropamide, tolazamide ) TZDs (pioglitazone, pioglitazone/metformin, rosiglitazone, rosiglitazone/metformin DPP4s (sitagliptin, saxagliptin, linagliptin, alogliptin) GLP1 (exenatide, liraglutide, dulaglutide) SGLT-2 (empagliflozin, canagliflozin, dapagliflozin) | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Pain Must either be getting her first mammogram or based on prior experience be expecting level 4 or 5 pain Must have two breasts May not have taken ibuprofen or other pain medication within the Space last 12 hours (ASA 81 mg dose is allowed) Must not have a contraindication for using lidocaine: e.g no history of allergic reactions to lidocaine Must not have had history of breast cancer, breast surgery, radiation to the chest wall Must not have broken or irritated skin (as determined by the study nurses) May not be lactating or breast feeding | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Pain Hernia MUST HAVE TO Inclusion/ Active Duty members and DoD beneficiary patient 18 years or older Elective, open unilateral inguinal herniorrhaphy using Lichtenstein (tension free with mesh) hernia repair technique Agree to take only the prescribed oral analgesic medication (oxycodone/acetaminophen), plus or minus ibuprofen, for the initial fourteen-day post-operative period, with allowed exception of any currently prescribed opioid (codeine, hydrocodone, hydromorphone, morphine, methadone, oxymorphone, transdermal fentanyl), which can be continued.Agree to honestly complete a depression screening questionnaire, illicit drug use personal history and questionnaire, and physical activity assessment questionnaire, with the knowledge that if the patient is an active duty member, this information could result in a referral to medical or command authorities for potential Uniform Code of Military Justice (UCMJ) violations or concerns for subject health and fitness for duty Subjects who are pregnant or nursing Patients who refuse to complete the illicit drug use, physical activity, and depression questionnaires Strangulated, incarcerated, or otherwise emergent, urgent, and non-elective inguinal herniorrhaphy Those patients who are allergic to, refuse to take, or are otherwise unable to take oxycodone, ibuprofen, or acetaminophen medication orally for post-operative pain management Patients on pain contracts, or under the care of a pain medicine specialist for management of chronic pain at the time of surgery Subjects with serum creatinine level > 1.3 mg/dL as measured at the baseline study visit Subjects with serum aspartate transaminase (AST) greater than 3 times the upper limit of normal (level >102 U/L) Subjects with serum alanine transaminase (ALT) greater than 3 times the upper limit of normal (level > 165 U/L) | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Ischemic Stroke Informed volunteer consent, patient consent or personal consultee declaration form Male or female, aged 18 years or above Able (in the Investigator's opinion) and willing to comply with all study requirements Willing to allow his or her General Practitioner (GP) to be notified of participation in the study Stroke Patient-specific Clinical diagnosis of ischaemic stroke within 24 hours of onset (for patients waking with a stroke, time of onset will be taken to be the time when the patient was last asymptomatic) Male or Female, aged under 18 years Unable (in the Investigator's opinion) or unwilling to comply with any study requirements Participants who practice yoga regularly Female participants who are pregnant, lactating or planning pregnancy during the course of the study Stroke Patient-specific Clinical diagnosis of stroke greater than 24 hours from onset Having had a resolved transient ischaemic attack (TIA) (i.e. neurological symptoms completely resolved upon hospital presentation) Definite clinical indication to 'sitting up' (≥30⁰) head position (i.e. pneumonia, decompensated heart failure) Definite clinical indication to lying flat (0⁰) head position (i.e. shock, airways obstruction) Co-morbidity with anticipated life expectancy less than 3 months | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Cerebral Hemorrhage Age over 18 years old 2. CT scan diagnosis of an spontaneous intracerebral hemorrhage in the first 8h from the onset of the condition 3. Informed consent 4. Access to telephone evaluations (landline or mobile phone for the participant or a family member) GCS < 8 points 2. Secondary cause of the intracerebral hemorrhage (trauma, known AVM, aneurysm, hemorrhagic transformation of an ischemic stroke, thrombosis of central veins and sinuses, thrombolitic therapy, tumors, infections). 3. Severe disability prior to this hemorrhagic event (modified Rankin Score =>4); 4. Known venous thrombembolic condition 5. History of coagulopathy (genetic or acquired) 6. Recent ischemic events (< 12 months) (ischemic stroke, myocardial infarction, peripheric artheriopathy) 7. History of seizures (or present condition) 8. Undergoing treatment with heparin, LMWH, GPIIb/IIIa antagonists or oral anticoagulants (warfarin/ acenocumarol, factor Xa inhibitors, thrombin inhibitors in the last 14 days) 9. Pregnancy or breast feeding 10. Scheduled neurosurgical intervention on the next 24h 11. Ongoing of scheduled hemostatic treatment prothrombin, vitamin K, fresh frozen plasma, platelets 12. Enrollment in other clinical trials in the last 30 days 13. Known terminal stage disease | 1 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-75.0, Idiopathic Parkinson Patients Age ≥18，≤75，idiopathic Parkinson's disease，both male and female 2. MMSE score ≥24 3. H-Y score ≥2.0 on the medicine off situation 4. UPDRS-III score≥30 on the medicine off situation 5. The duration of this disease ≥5 years 6. Ability to provide informed consent as determined by preoperative neuropsychological assessment 7. History of appropriate response to dopaminergic medication, with at least a 30% improvement in motor UPDRS with L-DOPA by history or in-clinic testing, for the PD patients 8. Excellent responsiveness to levodopa 9. ≥6h in medicine off state Lack of ability to provide informed consent as determined by preoperative neuropsychological assessment 2. Otherwise not eligible for DBS surgery, for example known inability to undergo anesthesia 3. Hydrocephalus，brain atrophy，cerebral infarction ，cerebralvascular diseases 4. Patients who are unable to follow verbal instructions 5. Other severe pathological chronic condition that might confound treatment effects or interpretation of the data | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-65.0, Migraine migraine with or without aura diagnosed by a neurologist according to the of the International Headache Society (3nd edition) experience a minimum of two migraine attacks per month in a 3-month baseline phase without regular use of prophylactic treatments or unresponsive to two and more commonly applied preventive medications the presence of RLS confirmed by contrast-enhanced transcranial Doppler no positive findings in cranial CT and MRI other types of headaches systemic chronic diseases, cerebrovascular disease, abnormal platelet or liver function history of head injury other contraindications to clopidogrel treatment | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-80.0, Cerebral Cavernous Malformation Intracerebral Hemorrhage Patients with newly diagnosed cerebral cavernous malformation who agreed to participate years old or more Patients who underwent treatment(surgery or radiosurgery) for cavernous malformation Patients who are accompanied by other serious medical problems | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 0.538-0.712, Premature Birth Belong to the group of neonates treated in neonatal intensive care units during the dates on which the sample will be taken Clinical evaluation by the neonatologist indicating the infant's possible participation in the study The neonate is between the gestational age of 28 and 37 weeks Mother is not able to give consent due to mental incapacity | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-45.0, Headache Age 18 years or age or greater 2. Postpartum obstetric parturient who was previously admitted to UCH. 3. Diagnosis of post-dural puncture headache based on the International Classification of Headache Disorders: 1. Dural puncture has been performed 2. Headache has developed within 5 days of the dural puncture 3. Not better accounted for by another ICHD-3 diagnosis. 4. Occurring immediately or within seconds of assuming an upright position and resolving quickly (within 1 minute) after lying horizontally Refusal to participate in the study 2. Placement of an EBP within the past 5 days 3. Allergy and/or intolerance to any the study materials 4. Contraindications to an EBP 5. Plan for therapeutic anticoagulation post-partum | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Post-Traumatic Headache Male and female Active-duty SMs or Veterans aged 18 or older who are in good general health History of blast and/or impact head trauma mTBI meeting Defense and Veterans Brain Injury Center (DVBIC) mTBI criteria. o Mild TBI is defined as an injury to the head causing at least one of the following: alteration in consciousness (for up to 24 hours after the injury), loss of consciousness (0-30 minutes), and/or post-traumatic amnesia (up to 1 day post-injury). If available, the Glasgow Coma Scale score must be 13-15, and head imaging findings (if imaging was performed) must be negative Frequent HAs that started within 3 months after a head injury or marked worsening (a two-fold or greater increase in frequency and/or severity) of pre-existing headaches within 3 months of head injury HAs either 1) must last 4 or more hours a day and reach a moderate to severe intensity at any point during the headache, or 2) may be of any severity or duration if the participant takes a medication or other agent in an effort to stop or treat a headache HAs meeting these must have been present on average at least 8 days per 4-week period, starting within 3 months after head injury and occurring by self-report for at least 3 months prior to the Initial Screening Visit. The 4-week HA frequency/severity must be confirmed during the Preliminary Screening Period Women of childbearing potential must agree to abstain from sexual relations that could result in pregnancy or use an effective method of birth control acceptable to both participant and the clinician prescriber during the study. Men are not required to use contraception during the study Participants must have English fluency sufficient to complete study measures Participation in other interventional research History of penetrating head injury History of TBI more severe than mild by DVBIC A primary non migraine and/or tension-type HA disorder (for example hemicrania continua; cluster) that accounts for the majority of current symptoms HAs of any kind of moderate or severe intensity on an average of more than 4 days per month preceding the concussive trauma Acute or serious medical illness or unstable chronic medical illness (e.g., unstable angina, myocardial infarction within 6 months, congestive heart failure, clinically significant or concerning cardiac arrhythmias; preexisting hypotension [systolic blood pressure<110] or orthostatic hypotension [systolic drop >20 mm Hg after 2 min standing accompanied by lightheadedness], chronic renal or hepatic failure, or acute pancreatitis. The of potential participants having acute serious and/or chronic medical illnesses other than those listed will be evaluated on a case-by-case basis by a study physician, PA-C, or ARNP Use of prazosin or other alpha-1 antagonist (including but not limited to alfuzosin, doxazosin, silodosin, tamsulosin, terazosin) for any purpose in the 2 weeks prior to initial screen (P1) visit and prohibited throughout the study Allergy or previous adverse reaction to prazosin or other alpha-1 antagonist Active psychosis or psychotic disorder, severe depression (as determined per clinician prescriber judgment), severe psychiatric instability or severe situational life crisis (including evidence of being actively suicidal or homicidal) Meets Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) for any Substance Use Disorder except caffeine-related disorders, or tobacco-related disorders | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-100.0, Valvular Heart Disease Stenosis and Regurgitation (Diagnosis) Presence of aortic stenosis, mitral or aortic regurgitation at the time of an echocardiography at the "Cliniques Universitaires Saint Luc" | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-65.0, Anxiety Pain Health Knowledge, Attitudes, Practice Delivering the first child Planning to labor with neuraxial analgesia Additionally, there will need to be sufficient time before delivery to allow the completion of the Pre procedure questionnaire, State-Trait Anxiety Inventory (STAI) questionnaire both before and after the procedure, as well as the Newest Vital Sign questionnaire and the Pain Catastrophizing Scale questionnaire before the procedure They will be included if they are ASA (American Society of Anesthesiologists) 2 Able to read and comprehend the English language, as the Newest Vital Sign questionnaire requires them to read and interpret a nutrition label. Physician Anesthesiology Attending Physician, fellow or resident who participants in the placement of the epidural catheter placement Companion Primary companion identified by parturient over the age of 18 Parturients will be excluded if they are receiving neuraxial anesthesia for a cesarean delivery External cephalic version Non-labor procedure Subjects will be excluded if they begin to push for delivery before completion of the STAI questionnaire following labor epidural catheter placement They will be excluded if there is no support person present at the time of the neuraxial procedure They will be excluded if they are ASA 3 or greater, or if they have a contraindication to receiving any of the medications routinely used in the placement of a labor epidural catheter (lidocaine, bupivacaine, epinephrine, fentanyl) Adults who are unable to consent and minors will be excluded | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Post-Dural Puncture Headache Diagnostic for post dural puncture headache Moderate to severe post dural puncture headache Procedure failures: new dural puncture on epidural blood patch trial, unable to find epidural space, intolerance to insertion of nasal swabs Follow up loss | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 0.0-1.0, Congenital Malformations Criteria:All babies with abnormal fetal ultrasounds - Normal babies who die in the neonatal period because of other causes not associated with lethal malformations - | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Vascular Malformations Patients with venous or mixed venous-lymphatic malformation Patients which are regular scheduled for a percutaneous treatment of a vascular malformation Informed Consent as documented by signature Age < 18 years | 1 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-50.0, PostTraumatic Stress Disorder Able to give informed consent Right-handed Age between 18-50 years old Physically and neurologically healthy [confirmed by a comprehensive medical history] Current PTSD diagnosis clinically significant medical or neurologic condition or neurocognitive dysfunction that would affect function and/or task performance and/or interfere with the study protocol any current (or within past 2 months) medical condition requiring medication that would interact with dronabinol or interfere with the study protocol risk of harm to self or others that requires immediate intervention presence of contraindications, current or past allergic or adverse reaction, or known sensitivity to cannabinoid-like substances (dronabinol/marijuana/cannabis/THC, cannabinoid oil, sesame oil, gelatin, glycerin, and titanium dioxide) lack of fluency in English positive drug screen or alcohol breathalyzer unwilling/unable to sign informed consent document currently pregnant (positive pregnancy test), planning pregnancy, or lactating (women) under 18 or over 50 years of age traumatic brain injury (as defined by The American Congress of Rehabilitation as a person who has had a traumatically induced physiological disruption of brain function (i.e., the head being struck, the head striking an object, and/or the brain undergoing an acceleration/deceleration movement (i.e., whiplash) without direct external trauma to the head), as manifested by at least one of the following: any loss of consciousness; any loss of memory for events immediately before or after the injury; any alteration in mental status at the time of the incident; or focal neurological deficits that may or may not be transient) | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Stomach Neoplasm GastroEsophageal Cancer Adenocarcinoma Locally Advanced Cancer Chemoradiation Age >=18 years Female and male Eastern Cooperative Oncology Group (ECOG) performance status 0-1 Life expectancy >=6 months Histologically proven adenocarcinoma of the stomach or gastroesophageal junction (GEJ) (excluding Siewert I) that is: Stage IIB (T3N1 only), IIIA (T2N3 not eligible), IIIB, and IIIC, i.e. T3 T4a and node positive, or T4b and/ or node positive, according to American Joint Committee on Cancer (AJCC) 7th edition Considered operable following initial staging investigations or after pre-operative therapy Disease which can be radically treated with radiotherapy to 45 Gy with standard fractionation Adequate organ function defined as follows Bone marrow: Haemoglobin >=90 g/L, Absolute neutrophil count (ANC) >=1.5 x 109 /L, Platelet count >=100 x 109 /L; Hepatic: Serum bilirubin <=1.5 x upper limit of normal, aspartate aminotransferase (AST) and/or alanine transaminase (ALT) <=2.5 x upper limit of normal; Renal: Serum creatinine <=1.0 x upper limit of normal Patients are willing to obey the treatment and provide blood and tissue specimens Pregnant or lactating females or female patients of childbearing potential who have not been surgically sterilized or are without adequate contraceptive measures Sexually active males or females refuse to practice contraception during the study until 30 days after end of study Evidence of metastatic disease Prior chemotherapy or radiotherapy Patients with a past history of cancer in the 5 years before randomization except for the squamous or basal cell carcinoma of the skin that has been effectively treated, and carcinoma in situ of the cervix that has been treated by operation Patients with other significant underlying medical conditions that may be aggravated by the study treatment or are not controlled Patients with central nervous system(CNS) disorder or peripheral nervous system disorder or psychiatric disease Known history of uncontrolled or symptomatic angina, uncontrolled arrhythmias and hypertension, or congestive heart failure, or cardiac infarction within 6 months prior to study enrollment, or cardiac insufficiency Concurrent severe infection Severe gastrointestinal bleeding, gastrointestinal perforation | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 0.0-999.0, Spinal Cord Vascular Diseases patient diagnosed with spinal vascular diseases including intradural arteriovenous malformation intradural arteriovenous fistula dural arteriovenous fistula extradural arteriovenous malformation paravertebral arteriovenous malformation paravertebral arteriovenous fistula cobbs' syndrome other spinal arteriovenous metameric syndromes involve the spinal cord patient not received surgical or interventional treatment before patient received surgical treatment or interventional treatment before patient is pregnant patient allergic to iodine patient unable to complete follow-up patient with cerebral lesions patient with other spinal lesions patient with cardiac, renal or hepatic dysfunction | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-55.0, Diabetes Mellitus The patient is a pregnant female 18 years of age or older 2. The patient has been diagnosed with gestational diabetes or is a patient with known diabetes and a confirmed viable pregnancy 3. The pregnancy has a singleton pregnancy 4. The patient has access to a cellular phone with a text messaging plan The patient does not have a cellular phone 2. The patient becomes hospitalized for a pregnancy complication for the remainder of pregnancy 3. The fetus has a chromosomal or non-chromosomal malformation | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-80.0, Migraine Disorders Migraine, Classic Migraine Without Aura Subjects with a documented diagnosis of migraine by a neurologist Subjects refractory to standard migraine therapy with persistent severe, debilitating symptoms Subjects without changes to their neurological exam within the preceding 6 months Migraines at least twice a month Migraines unique and distinguishable from other non-migraine headache pain Subjects must sign a consent form for both angiography and for participation in this study, and must be willing to undergo angiography for the evaluation of their symptoms Subjects taking vasoactive drugs including epinephrine, norepinephrine, dopamine, dobutamine, isoprenaline, dopexamine, milrinone, amrinon, levosimendan, glucagon, phenylephrine, metaraminol, ephedrine, vasopressin, digoxin, and levothyroxine Subjects with underlying cardiac pathology including but not limited to coronary artery disease, heart attacks, or severe atherosclerosis Subjects with severe pulmonary disease requiring supplemental oxygen therapy Subjects taking medications similar to nitroglycerin such as phosphodiesterase inhibitors Subjects with contraindications to nitroglycerin or calcium channel blocker use Subjects who have had coffee, tea, or alcohol in the 12 hours before the start of the angiogram Subjects having other headache conditions or pain syndromes Subjects with prior intracranial therapies or craniotomies for management of any intracranial lesions Subjects in whom the angiography demonstrates severe vessel tortuosity or stenosis, vasospasm not responsive to medical therapy, or abnormal communication between intracranial and extracranial vessels either in the past or during the study procedure Subjects who are not able to reliably report symptoms | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 21.0-999.0, Subarachnoid Hemorrhage Cerebral Vasospasm Age >= 21 2. Onset of symptoms within 72 hours from presentation 3. Subarachnoid hemorrhage from ruptured cerebral aneurysm 4. Cerebral vasospasm diagnosed on transcranial doppler, CT angiography, or digital subtraction angiography Pregnancy 2. Subarachnoid hemorrhage secondary to traumatic or mycotic aneurysm 3. Pre-ictal sildenafil therapy (last dose within 1 week of presentation) 4. Contraindications to sildenafil therapy (i.e. use of nitrates, left ventricular outflow obstruction, impaired autonomic blood pressure control) | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Arteriovenous Malformations Informed consent 2. Brain AVMs previously diagnosed with either CT Angiography, MRI or catheter angiography. 3. Undergoing cerebral catheter angiography for clinical evaluation of the brain AVM. Patients with brain AVMs scheduled for catheter cerebral angiography will undergo MRI (GE 3T) within 3 months. 4. Age > 18 years. 5. mRS <=2 6. Brain AVM visible on MRI, i.e. nidus > 1 cm Contraindication to MRI eg. Non-MRI compatible implant, severe claustrophobia 2. Contraindication for contrast: GFR < 60 ml/min, allergy to contrast | 2 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Stroke A stroke caregiver is eligible to participate in the study if: 1. He / She is a Chinese adult aged 18 or above; 2. He / She has a family member has the first stroke (ischaemic or haemorrhagic stroke) at the age of 50 or above and has been discharged from the acute hospital for no more than 6 months; 3. He / She provides care or being with the stroke survivor for no less than two hours per day after discharge from the acute hospital; 4. He / She reports significant caregiver burden as measured by the 12-item Zarit Burden Interview (a total score ≥ 12). A stroke survivor is eligible to participate in the study if: 1. He / She is a Chinese adult aged 50 or above; 2. He / She has been discharged from the acute hospital for no more than 6 months; 3. His / Her family caregiver participates in this study; 4. He/ She is able to communicate with interventionists and interviewers; 5. He/ She is competent to give written informed consent. Stroke survivors whose caregivers in the intervention group will receive both the intervention and the questionnaire interviews. Stroke survivors whose caregiver in the control group will only need to take part in the questionnaire interview A stroke caregiver will be excluded from participation if: 1. His / Her family member has a transient ischaemic attack without a major ischaemic or haemorrhagic stroke; 2. His / Her family member with stroke is residing in a residential care facility after discharge from the acute hospital; 3. He / She is diagnosed as having Alzheimer's disease or other dementias; 4. He / She is unable to understand Cantonese. A stroke survivor is not eligible to participate in the study if: 1. He / She is residing in a residential care facility after discharge from the acute hospital; 2. He/ She has a transient ischaemic attack without a major ischaemic or haemorrhagic stroke; 3. His / Her family caregiver refuses to participate in this study; 4. He/ She is not able to communicate with interventionists and interviewers; 5. He/ She is not competent to give written informed consent | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 1.5-80.0, Headache, Migraine Woman Aged from 18 to 80 Benefiting from social security scheme or legal successor Having given their non-opposition to the study; · Diagnosis of chronical migraine for more than 6 months Without background treatment or with stable background therapy for more than 1 month Presenting a calendar of migraines and headaches mentioning the number of days with pain, intensity of pain and treatments for at least 3 months. Non Man Patient with less than 6 painful episodes in 3 months History or actual mental health disorder Allergy or infection of the auricle Pregnancy | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Tension-Type Headache Diagnosis of Tension-Type Headache according to the of ICDH-III Currently undergoing physiotherapy treatment for headache Modification of pharmacological treatment in the last month Presence of red flags | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Post-Traumatic Headache Traumatic injury to the head has occurred Headache has developed within 7 days of injury to the head Headache is not better accounted for by another diagnosis (eg, previous history of migraine or tension-type headache) The headache must be rated as moderate or severe in intensity at the time of initial evaluation The plan of the attending emergency physician must treatment with parenteral metoclopramide Patients will be excluded if more than ten days have elapsed since the head trauma, if the headache has already been treated with an anti-dopaminergic medication, or for medication contra-indications including pheochromocytoma, seizure disorder, Parkinson's disease, use of monoamine oxidase inhibitors, and use of anti-rejection transplant medications. Patients will not be excluded for pregnancy or breast-feeding | 2 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-65.0, Anesthesia patients undergoing brain arteriovenous malformation embolization in the fist affiliated hospital, Sun Yat-sen University, aged 18-65 years, available to chat with,and the tracheal tube was extubated after surgery immediately abuse anesthetic analgesics and sedative drugs, or allergic to Dexmedetomidine or other anesthetics, hypotension or bradycardia before surgery, severe pulmonary disease with saturation of pulse oximetry less than 90% before surgery, or patients refused to attend in this study | 1 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-50.0, Post-Dural Puncture Headache Chronic Headache Chronic Low Back Pain Index: Participants aged over 18 years who have sustained accidental dural puncture with 16-gauge Tuohy needle Control: Participants aged over 18 years who have received uneventful epidural insertion with 16-gauge Tuohy needle Lack of consent including from those participants who lack mental capacity to give informed consent Pre-existing chronic headache (the patients suffer from 15 or more headache days every month) Pre-existing chronic low back pain (the patients suffer from 7 or more low back pain days every month) | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Intracerebral Hemorrhage Stroke Hematoma Age >= 18 years Informed consent to participate in the study Patients diagnosed with CT-confirmed spontaneous Intracerebral Hemorrhage (ICH) Patients are willing to participate in the follow up assessment Did not agree to participate in the study Secondary ICH to hemorrhagic infarction or tumor bleeding etc Traumatic ICH | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-45.0, Intervention Study Pregnant women between 14 to 28 weeks of gestational age and those who plan to deliver in the study hospital and reside in the study location for the next five years. She must be able to speak Kannada, Hindi or English and should be willing to provide informed consent voluntarily. The participant must own or have sufficient access to a cell phone and should be able to operate a cell phone with a partner, relative, etc who stay with her Diabetes or Hepatitis B infection HIV positivity Pregnant women of other gestational ages | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-45.0, Parkinson Disease Male or female subjects aged between 18 and 45 years, inclusive Subjects of body mass index (BMI) between 19 and 30 kg/m2, inclusive Subjects who were healthy as determined by pre-study medical history, physical examination, vital signs, complete neurological examination and 12-lead ECG Subjects who had negative tests for HBsAg, anti-HCVAb and HIV-1 and HIV-2 Ab at screening Subjects who had clinical laboratory test results clinically acceptable at screening and admission Subjects who had a negative screen for alcohol and drugs of abuse at screening and admission Subjects who were non-smokers or who smoked ≤ 10 cigarettes or equivalent per day Subjects who were able and willing to gave written informed consent (If female) She was not of childbearing potential by reason of surgery or, if of childbearing potential, she used one of the following methods of contraception: double barrier, intrauterine device or abstinence (If female) She had a negative urine pregnancy test at screening and admission Subjects who had a clinically relevant history or presence of respiratory, gastrointestinal, renal, hepatic, haematological, lymphatic, neurological, cardiovascular, psychiatric, musculoskeletal, genitourinary, immunological, dermatological, endocrine, connective tissue diseases or disorders Subjects who had a clinically relevant surgical history Subjects who had a clinically relevant family history Subjects who had a history of relevant atopy Subjects who had a history of relevant drug hypersensitivity Subjects who had a history of alcoholism or drug abuse Subjects who consumed more than 14 units of alcohol a week Subjects who had a significant infection or known inflammatory process on screening or admission Subjects who had acute gastrointestinal symptoms (e.g., nausea, vomiting, diarrhoea, heartburn) at the time of screening or admission Subjects who had used medicines within 2 weeks of admission that may affect the safety or other study assessments, in the investigator's opinion | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Physical Activity Patients receiving physical therapy at UAB hospital that require moderate assistance or greater with sit-to-stand transfers during initial evaluation Patients with baseline function of supervision as obtained in the initial physical therapy (PT) evaluation Patients who have an inpatient hospital stay of at least 4 days Patients with diagnoses that are progressive in nature Patients in intensive care units due to critical medical condition and confounding factors Patients with cognitive impairment as noted in the medical record Patients with weight bearing precautions other than free weight bearing (FWB) or weight bearing as tolerated (WBAT) Children (under the age of 18), prisoners and pregnant women Patients who are not able to speak English | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Benign Tumors Malignant Tumors Vascular Malformation Preoperative 1. Patient undergoing elective craniotomy/craniectomy for pathological processes (such as benign and malignant tumors, vascular malformation) in the posterior fossa or in the supratentorial region. 2. Age ≥ 18 years. 3. Patients who are able and willing to comply with the procedures required by the protocol. 4. Signed and dated written informed consent from the subject or from his/her legal representative prior to any study-specific procedures Intraoperative 1. Patient undergoing elective craniotomy/craniectomy for pathological processes (such as benign and malignant tumors, vascular malformation) in the posterior fossa or in the supratentorial region and who are demonstrated to have persistent CSF leakage following suture closure of the dural incision. CSF leakage will be evaluated during a period of Valsalva of 10-20 cm of H20 for 5-10 seconds. If a spontaneous leak is apparent immediately after dural closure, no Valsalva will be performed. 2. Surgical wound classification Class I. Penetration of mastoid air cells during partial mastoidectomy is permitted. 3. The cuff of native dura along the craniotomy edge is ≥10 mm wide, to facilitate suturing and to allow for sufficient surface area for adherence of the investigational product Preoperative 1. Subjects with a dura lesion from a recent surgery that still has the potential for CSF leakage. 2. The previous craniotomy/ craniectomy within 6 months or radiation therapy within 2 years before this surgery. 3. Chemotherapy or radiation therapy scheduled within 7 days following surgery. 4. Subjects with severely altered renal (serum creatinine >2 mg/dL) and/or hepatic function [ALT, AST > 5 x upper limit of norm (ULN)]. 5. Severe Anemia (Hemoglobin <60 g/L) or Hypoproteinemia (Total protein <60 g/L or 6g% ) . 6. Non-compliant or insufficient treatment of diabetes mellitus [glycosylated hemoglobin (HbA1c) > 7.5%]. 7. Conditions compromising the immune system; existence of autoimmune disease. 8. Evidence of a potential infection: fever >38℃, WBC <3500/uL or >13000/uL, positive urine culture, positive blood culture, positive chest X-ray, evidence of infection along the planned surgical path. 9. Known hypersensitivity to the porcine fibrin sealant product. 10. Female subjects of childbearing potential with a positive urine or serum pregnancy test within 7 days prior to surgery. 11. Female subjects who are breastfeeding or intend to become pregnant during the clinical study period. 12. Participation in another clinical trial with exposure to another investigational drug or device within 30 days prior to enrolment Intraoperative 1. Native dura cuff during craniotomy/craniectomy that cannot be completely repaired. 2. Use of implants made of synthetic materials coming into direct contact with dura (e.g., PTFE patches, shunts, ventricular and subdural drains). 3. Occlusive hydrocephalus caused by posterior fossa pathology or partial blockage of CSF pathways during surgical procedure. 4. Existing CSF drains on the surgical path. 5. Use of other fibrin sealants for hemostasis. 6. Placement of Gliadel Wafers or similar products. 7. Persistently increased brain surface tension that may lead to an incomplete repair requiring. 8. Intersecting durotomy scars in the surgical path from a previous operation that cannot be completely removed by the planned dura resection. 9. Two or more separate dura defects during surgery. 10. Others in addition to above the subject, in the opinion of the investigator, would not be suitable for participation in the study | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 0.0-999.0, Neonatal Thrombocytopenia Intraventricular Hemorrhage Platelet Transfusion gestational age <34 weeks at birth platelet count <50x10^9/L readmission to NICU (only first admissions are included. Postnatal transfers from non-NICU hospitals are included) major congenital malformations high suspicion of spurious platelet count thrombocytopenia exclusively in the context of exchange transfusion | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 21.0-80.0, Temporal Cephalic Pain Shear noise and/or tooth-grinding, confirmed by a room companion or family member. Observation of wear facets on the tooth surfaces, incompatible with age and function. Presence of two or more symptoms, such as headache in the temporal region, rigid jaw muscles or fatigue at night or upon awakening, locking or difficulty in opening the mouth in the morning, dental hypersensitivity, hypertrophy of the masseter muscles Currently in treatment for bruxism, through the use of an interocclusal stabilization splint. Patients with alcoholism. Patients who make use of medications that affect episodes of bruxism, such as analgesics, anti-inflammatories, muscle relaxants, amphetamines, and inhibitors of serotonin reuptake | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-49.0, Gestational Diabetes Obese pregnant women with BMI > 30 kg/m2 2. First prenatal visit or subsequent visit prior to 20 weeks of gestation 3. Maternal age > 18 years 4. Willingness to participate in the study and give informed consent Pre-existing DM or pre-gestational diabetes mellitus, 2. Gestational age more than 20 weeks at time of enrollment 3. Unknown or inability to determine gestational age even with last menstrual period 4. Previous medical history of gestational diabetes mellitus. 5. Known impaired glucose metabolism 6. HbA1C > 6.5 % | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-65.0, Chronic Tension-Type Headache Meeting the diagnostic of CTTH in the international classification of headache disorders, 3rd edition (beta version) (ICHD-III beta); 2. Aged 18-65 years; 3. Having the ability of understanding and completing the headache dairy; 4. Volunteering to this study and able to provide written informed consent Not suffering tension-type headache during the pervious 3 months; 2. Taking any prophylactic headache medication during the previous one month; 3. Headache due to organic disorders (e.g. subarachnoid hemorrhage, cerebral hemorrhage, cerebral embolism, cerebral thrombosis, vascular malformation, arthritis, hypertension, arteriosclerosis); 4. Having serious diseases of the heart, liver, kidney or other organs; 5. In pregnancy or lactation, or planning to be pregnant in 6 months; 6. In unconsciousness, or having psychosis; 7. Having bleeding disorders or getting infectious; 8. Unwilling to take parts in this study or with low compliance; 9. Addicted to smoking, alcohol or drugs; 10. Taking parts in other clinical studies at the same time | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Reversible Cerebral Vasoconstriction Syndrome Patients 18 years of age or greater meeting the following adapted from Singhal and colleagues 2 will be included: 1. presentation consistent with RCVS acute thunderclap/severe headache and **supporting clinical features should prompt increased clinical suspicion (eg., potential medication trigger, recent pregnancy, migraine history)** evidence of beading/elevated velocities on imaging (Transcranial Doppler (TCD), angiogram, Computer Tomography Angiogram (CTA), MRA) and reversibility (by 90 days)-will not be required for but will be retrospectively adjudicated Participants will be excluded from the study if they are unable to consent AND no family present to consent, or have presence of aneurysmal, traumatic, or mesencephalic Subarachnoid Hemorrhage (SAH), or have presence of other supported diagnosis (eg., vasculitis inflammatory lumbar puncture) or are currently pregnant or the use of nimodipine or verapamil is contraindicated for any reason (eg., allergy, breast feeding) or | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-50.0, Adrenal Hyperplasia, Congenital Patients with CAH, born between 1970 and 1998, having received GH treatment for a minimal one year duration Patients with chronic any growth altering disease, Turner syndrome or other genetic anomaly; 8-year wrist Xray and adult height should be available to allow the use of the OPALE model prediction | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Spontaneous Intracerebral Hemorrhage Spontaneous Primary Intracerebral Hemorrhage Secondary ICH etiology (i.e. AVM, SAH, SVT, Fistulas, Tumor, Trauma) ICH patients on active anticoagulation (known NOAC intake, INR Level on Admission >1.4) Patients with intraparenchymal hemorrhage after Thrombolysis | 1 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Cardiac Pacing, Artificial Aneurysm, Brain Arteriovenous Malformations, Cerebral elective cerebral aneurysm clipping surgery arteriovenous malformation surgery craniotomy American Society of Anesthesiologists 1,2 and 3 cardiac abnormalities coronary heart disease valvular heart disease pregnancy | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Cerebral Hemorrhage Intracranial Hemorrhages Atrial Fibrillation Anticoagulant-Induced Bleeding Secondary Prevention Patient age ≥18 years Spontaneous, primary ICH, of ≥1 day, but not more than 180 days after onset of qualifying ICH, i.e No preceding traumatic brain injury, based on history from the patient/witness of spontaneous symptom onset, and brain imaging appearances consistent of spontaneous ICH (i.e. any brain/bone/soft tissue appearances of trauma must have occurred secondary to a spontaneous ICH) No 'secondary' or underlying structural cause (e.g. haemorrhagic transformation of an ischaemic stroke, aneurysm, tumour, arteriovenous malformation, or intracerebral venous thrombosis) Patient have indication for antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of ischaemic events, either antiplatelet drugs (for patients with vascular disease), or anticoagulant drug for patients with atrial fibrillation Consent to randomisation from the patient (or personal / legal / professional representative if the patient does not have mental capacity) MRI (or CT) is performed before randomisation Clear indication for antiplatelet or anticoagulant treatment (e.g. prosthetic heart valves) Contraindications to the antithrombotic drug that will be administered Patient is pregnant, breastfeeding, or of childbearing age and not taking contraception For patients examined with MRI: Contraindication for brain MRI Malignancy with life expectancy less than 2 years | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Postoperative Pain Postoperative Nausea and Vomiting Quality of Life Breast Cancer Breast Prosthesis; Pain Be women, aged 18-75 years Choose bilateral mastectomy (therapeutic or prophylactic) followed by immediate, bilateral pre-pectoral tissue expander breast reconstruction with complete AlloDerm® coverage Have no inflammatory breast cancers Be aware of the nature of her malignancy Understand the study purpose, requirements, and risks Be able and willing to give informed consent Plan to undergo final reconstruction with autologous material Allergies to gentamicin, cefoxitin, lincomycin, vancomycin, or polymixin (antibiotics used in the pre-treatment of AlloDerm®) Active connective tissue disease Current smokers History of, or plan to undergo irradiation of the breasts | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 60.0-120.0, Osteo Arthritis Knee Criteria:• Patients undergoing primary TKR at the RD+E Hospital Patients must have completed a consent form for the study Patients must be prepared to comply with the pre and post-operative investigations, rehabilitation, attendance schedule and questionnaire schedule of the study Patient in whom any varus deformity present is <20° The diagnosis is of tricompartmental osteoarthritis of the knee Patient has primary diagnosis of Non-Inflammatory Degenerative Joint Disease (NIDJD) BMI<40 Aged =/> 60 years at time of surgery • Refusal to consent to the study If the knee for surgery has a fixed flexion deformity ≥15° this will be assessed by a lateral "heel-hang" x-ray of the knee for surgery If the knee for surgery has a varus deformity ≥20° If the knee for surgery has a valgus deformity i.e. hip/knee/ankle alignment angle <0° Pre-op Oxford Knee Score <8 Pre-op knee flexion ability <90° If the natural posterior tibial slope measured is in excess of 10° Any patient whose post-operative recovery or ability to comply with the post-operative rehabilitation and assessment schedules is compromised by known existing other medical conditions Pregnancy | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 0.423-0.538, Ophthalmological Disorder Subjects must meet all the following to be permitted into this study Signed informed consent from parents/guardians Subject must be born before 28 weeks of gestation Subjects presenting with any of the following will be excluded from the study Detectable clinical gross malformation Known or suspected chromosomal abnormality, genetic disorder, or syndrome, according to the investigator's opinion Clinically significant neuropathy, nephropathy, retinopathy, or other micro or macrovascular disease requiring treatment, according to the investigator's opinion Any other condition or therapy that, in the investigator's opinion, may pose a risk to the subject or interfere with the subject's ability to be compliant with this protocol or interfere with interpretation of results | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Cerebral Hemorrhage Stroke Hypertension Diabetes Anticoagulant-induced Bleeding Cerebral Vascular Disorder Brain Disorder Hemorrhage Intracranial Hemorrhages Cardiovascular Diseases Central Nervous System Diseases Aged ≥18 years Acute stroke syndrome that is due to presumed spontaneous ICH, confirmed by clinical history and a CT scan within 6 hours of stroke onset without/without contrast, and if an CT angiogram is also undertaken as part of routine care Presentation to hospital within 6 hours of stroke onset Definite evidence that the ICH is secondary to a structural abnormality in the brain (eg an AVM, intracranial aneurysm, tumour, trauma, or previous cerebral infarction) or previous thrombolysis A high likelihood that the patient will not adhere to the study treatment and follow-up regimen. In each case, the decision about the patient's will be based on the attending clinician's interpretation of the above criteria | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 15.0-90.0, Cerebrovascular Disorders * patients with acute Stroke (Hemorrhagic and Non Hemorrhagic) patients who do not agree to continue cooperation patients with incomplete documents | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Post-Traumatic Headache Included patients will be adults who meet International Classification of Headache Disorders for acute post-traumatic headache. These are as follows Traumatic injury to the head has occurred Headache has developed within 7 days of injury to the head Headache is not better accounted for by another diagnosis (eg, previous history of migraine or tension-type headache) The headache must be rated as moderate or severe in intensity at the time of initial evaluation Patients will be excluded if more than ten days have elapsed since the head trauma, if the headache has already been treated with an anti-dopaminergic medication, or for medication contra-indications including pheochromocytoma, seizure disorder, Parkinson's disease, use of MAO inhibitors, and use of anti-rejection transplant medications | 2 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 20.0-65.0, Traumatic Brain Injury Patients underwent decompression via removal of bone flap in the unilateral frontal temporal lobe due to craniocerebral injury and developed no postoperative infection Patients agreed to receive skull repair using titanium mesh Patients and their families agreed to receive CT perfusion examination Patients and their families fully understood the study protocol and agreed to participate in the trial, and then singed the informed consent before the trial Hypertension and diabetes out of control, severe heart disease, brain tumors, brain abscess, and cerebral infarction Diseases that have interfered with localized perfusion data, such as intracranial aneurysms, arteriovenous malformations Combined with depressed skull fractures and skull base fractures Hydrocephalus | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-80.0, Sudden Sensorineural Hearing Loss (SSNHL) Adults aged 18 to 80 years old Present to the Otology or Otolaryngology Clinic at the University of Colorado Hospital with unilateral sudden sensorineural hearing loss (SSNHL) Seen within six weeks of initial hearing loss Unilateral hearing loss at screening as defined by Loss of 30 decibels (dB) HL or greater over 3 continuous frequencies with participants reporting that this hearing loss occurred within 3 days Present with primary complaint of sensorineural hearing loss Normal tympanometry (Type A) Normal tympanic membrane Participants for whom high dose corticosteroids are a contraindicated due to Pregnancy Known allergies to corticosteroids Other concurrent medical conditions and or medications where high dose oral corticosteroids are not safe to use Participants who have Type 1 or Type 2 diabetes Participants who have previously received a course of oral steroids for this indication Participants who have bilateral SSNHL Participants with conductive hearing loss, mixed hearing loss (sensorineural and conductive), or any type of hearing loss that is not SSNHL (i.e. caused by acoustic or physical trauma to the ear) Participants with the following conditions/situations will be excluded because the possibility that these could cause SSNHL History of previous/recurrent unilateral SSNHL | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Migraine Eligible patients are adults who present with an acute moderate or severe headache meeting migraine headache as defined by the International Classification of Headache Disorders-3β (1.1, migraine without aura). Patients who meet for Probable Migraine without Aura (1.5.1) will also be included, provided they have had at least one similar attack previously Patients will be excluded if informed consent cannot be obtained, if there is concern for a secondary cause of headache, if the maximum documented temperature is greater than 100.3 degrees, for a new objective neurologic abnormality, skull defect, suspected infection overlying injection site, known bleeding disorder, ongoing use of anti-platelet agents including P2Y12 platelet inhibitors (clopidogrel, prasugrel, ticagrelor), heparins, warfarin, or 10a inhibitors (rivaroxaban, apixaban, edoxaban, fondaparinux), prior treatment with a greater occipital nerve block, allergy to the investigational medications, pheochromocytoma, seizure disorder, Parkinson's disease, use of MAO inhibitors, and use of anti-rejection transplant medications | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Post-Traumatic Headache Chronic Without Intractable Headache In order to be included in the study, you must be a person of either gender who is at least 18 years of age, meets of having had a traumatic brain injury, a physiological disruption of brain function, as manifested by at least one of the following: 1. . Any period of loss of consciousness 2. . Any loss of memory for events immediately before or after the accident 3. . Any alteration of mental state at the time of the accident (e.g., feeling dazed, disoriented, and confused) 4. . Focal neurologic deficits that may or may not be permanent Traumatically induced includes the head being struck, the head striking an object, or the brain undergoing an acceleration/deceleration movement (i.e. whiplash) without direct external trauma to the head Meets Internation Classification of Headache Disorders-version III (ICHD-III) for persistent post-traumatic headache which is defined as a headache of at least 3 months duration caused by a traumatic injury to the head Meets ICHD-III for episodic/chronic migraine, with or without aura (excepting for organic disease): 1. . Headache attacks lasting 4-72 hours (untreated or unsuccessfully treated) 2. . Headache has at least 2 of the following characteristics: 1. unilateral location 2. pulsating quality 3. moderate or severe pain intensity 4. aggravation by or causing avoidance of routine physical activity (eg, walking or climbing stairs) 3. . During headache at least 1 of the following: 1. nausea and/or vomiting 2. photophobia and phonophobia A potential candidate for this study must be under the care of a physician for headaches and have an incomplete response to standard headache treatments Must have headache frequency of more than 8 days per month Must have a headache history of more than 6 months Must be able to attend or remotely participate (by video conference or telephone) in seven dietitian counseling sessions, and adhere to diet supplied to study participants Must be a Department of Defense (DoD) healthcare beneficiary and eligible to receive care at Walter Reed National Military Medical Center (WRNMMC), Fort Belvoir Community Hospital (FBCH) or Womack Army Medical Center (WAMC) A person cannot be in this study if they have a history of specific food allergies, especially to fish, dairy or gluten. Also exclusionary are Pregnancy or anticipated pregnancy Aversion to eating fish History of organic brain disorder other than TBI (vasculitis, encephalitis, meningitis, brain tumor) Major medical illness such as malignancy, diabetes, autoimmune or immune deficiency disorders, history of stroke or myocardial infarction Anticipated deployment or move to alternate location in the next 16 weeks Inability to read and communicate in English Regular use of fatty acid containing supplements Active or recent (2 years) history of treatment for substance abuse Cognitive impairment that prevents understanding of the protocol and completion of study procedures including compliance with the diet, blood draws and maintaining a daily headache diary | 1 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-75.0, Arthroplasty, Replacement, Hip Informed consent form (signed by participant and investigator) Primary implantation Suffer from primary or secondary osteoarthritis of the hip, femoral head and neck fractures or necrosis of the femoral head. In all cases a stable anchoring of the implant has to be possible Age at between 18 and 75 years old Willing to participate in the follow-up examinations Complete recovery is expected Missing informed consent form (signed by participant and investigator) Known or suspected non-compliance (e.g. drug or alcohol abuse) Enrolment of the investigator, his/her family, employees and other dependent persons Patients younger 18 years old Revision surgery Presence of sepsis or malignant tumours ASA (American Society of Anesthesiologists) Classification >3 Pregnancy | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Cerebrospinal Fluid Leaks Adult patients meeting International Classification of Headache Disorders 3rd Edition (ICHD-3) for a diagnosis of SIH (Table 1) who have had a contrast-enhanced brain MRI and a myelogram confirming the presence of a CSF leak will be recruited from the Duke Radiology spine intervention clinic [25] recent (i.e., < 2 weeks) blood patch contraindication or inability to undergo the procedure inability to provide informed consent expected inability to complete follow-up assessment a contraindication to receiving contrast material (precluding an epidurogram) contraindication to receiving fibrin glue (i.e., allergy) | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-55.0, Traumatic Brain Injury Post-concussive Headaches Between the ages of 18 and 55 Able to provide informed consent History of mTBI per the Ohio State University TBI-ID (OSU-TBI-ID) History of PCH pain (TTH, migraine, or mixed), with onset of pain or increase in previous headache pain having occurred within one month of mTBI as determined by structured examination using outlined in the International Classification of Headache Disorders-3 beta (ICHD-3 beta) Duration of PCH pain being greater than one year as determined by structured medical examination Score of >49 on the Headache Impact Test-6 (HIT-6) Medical clearance by study provider to participate in yoga protocol Younger than 18, or older than 55 years of age Active substance dependence, excluding Cannabis dependence (based on local issues regarding the legality of cannabis), as determined by structured clinical interview Moderate to severe TBI as determined per the OSU-TBI-ID Identification of active psychosis as determined by structured clinical interview Failing to receive medical clearance by study provider Inability to participate in the manualized intervention without postures being significantly modified Already participating in an ongoing consistent yoga practice (two or more times weekly) Involvement in another research interventional trial aimed at addressing pain-related symptoms | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Csf Leakage male/female patient candidate for an endoscopic endonasal transphenoidal surgery, who need repair of the sellar floor as part of the surgical procedure Diabetes, heart diseases, immunological diseases, infectious diseases, bone diseases | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-101.0, Traumatic Brain Injury Aneurysmal Subarachnoid Hemorrhage severe, non-penetrating TBI or aSAH must have a ventriculostomy (EVD) placed by the UK Neurosurgery service within 12 hours of primary traumatic episode non-survivable brain injury or other organ system injury life expectancy is five days or less penetrating TBI status epilepticus upon arrival to the hospital severe ischemic heart disease or congestive heart failure, myocardial infarction, or spinal cord injury Takotsubo cardiomyopathy secondary to the SAH active cancer or have been treated for cancer within the previous 6 months | 1 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 0.0-70.0, Cerebral Aneurysm Arteriovenous Malformations All patients undergoing hybird surgery Poor general condition , severe primary disease, surgical contraindications 2. Patient or family refused surgery 3. Fusiform aneurysm,Traumatic aneurysm,Infectious aneurysms 4. Combined with other hemorrhagic cerebrovascular disease 5. Combined with malignant brain tumor 6. Perinatal, Pregnancy 7. Patients unwilling to participate in the trial | 1 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-60.0, Traumatic Brain Injury (TBI) The following diagnostic for MTBI based on the 1993 American Congress of Rehabilitation Medicine and recent recommendation from the DOD, and the current diagnostic adopted by the TBI Clinic will be used for the study. A traumatically induced physiological disruption of brain function, as manifested by at least one of the following any loss of consciousness any loss of memory for events immediately before or after the accident any alteration in mental state at the time of the accident, e.g feeling dazed disoriented confused) Focal neurologic deficit (s) that may or may not be transient but where the severity of the injury does not exceed the following loss of consciousness of approximately 30 min or less after 30 min, an initial Glasgow Coma Scale score of 13-15 pregnancy; To be eligible for the study and to ensure no pregnancy risk, you will need to utilize contraception or practice abstinence until your study participation is completed history of pacemaker implant any ferromagnetic material in the brain or body that would prohibit the patients from having a brain MRI, e.g bullet fragment shrapnel device implant history of dementia, major psychiatric or life threatening diseases presence of any other chronic neuropathic pain states history of seizure pending litigation | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 0.0-999.0, STEMI - ST Elevation Myocardial Infarction Glucagon-like Peptide-1 Bleeding Complications a diagnosis of STEMI and needed PCI patients with cancer patients who used DPP4 inhibitor patients who used GLP1 analogue | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Subarachnoid Hemorrhage, Aneurysmal Delayed Cerebral Ischemia Vasospasm, Cerebral Endothelial Dysfunction Age > 18 2. Head CT evidence of subarachnoid hemorrhage 3. Digital subtraction cerebral angiography or CT angiogram documenting the presence of a cerebral aneurysm Symptom onset compatible with SAH of > 3 days prior to admission to OHSU 2. Absence of an indwelling external ventricular drain 3. Administration of any of the following inducers/inhibitors of CYP3A4: ritonavir, indinavir, nelfinavir, saquinavir, clarithromycin, telithromycin, chloramphenicol, ketoconazole, itraconazole, nefazodone, cobicistat or enzalutamide. 4. Suspected or confirmed pregnancy 5. Preexisting severe neurologic deficit or condition 6. Chronic renal failure requiring dialysis 7. Severe terminal disease with life expectancy <6 months 8. Unable to read or understand written or spoken English or Spanish 9. Refusal of informed consent | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-50.0, Shoulder Instability Patients who experienced at least one shoulder dislocation Patients who are willing to participate in the study Patients who receive arthroscopic Latarjet procedure for treatment of glen-humeral instability Patients who are at least 18 years old Patients with an ISI-Score of at least 4 points Patients older than 50 or younger than 18 years of age Patients with painful unstable (multidirectional) instability Patients with congenital defects of the bones involved (humerus, scapula) Patients with an ISIS of smaller 4 points | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 0.0-999.0, Cerebral AV Malformation All patients with a ruptured or unruptured and previously endovascularly untreated cAVM that are eligible for endovascular treatment with PHIL® alone or in conjunction with N-Butyl cyanoacrylate glue (NBCA) and/or coils (e.g. if "pressure cooking" technique is needed or used). 2. All patients with a previously endovascularly treated cAVM in which NBCA and/or coils (but not another non-adhesive liquid embolic agent) have been used may be included.** 3. All patients with a remaining cAVM, ruptured or unruptured, that has previously been treated with NS and/or RT may be included. 4. Patient or patient's legally authorized representative has received information about data collection and has signed and dated an Informed Consent Form. (Based on the country's regulation) cAVM not eligible for endovascular treatment 2. cAVM previously treated with a non-adhesive liquid embolic agent other than PHIL® 3. Treatment requiring the use of any other non-adhesive embolic liquid 4. Patient is allergic to iodine 5. Premature and newborn infant 6. Patient with renal failure or significant liver impairment 7. Patient is participating in another study evaluating other medical devices, other procedures or medications. 8. Any other condition that might prevent patient participation in the study or follow up 9. Patient does not want to and/or refuses to give consent to the collection and processing of data required for centralized monitoring | 2 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 20.0-80.0, Cerebral Vascular Accident first stroke chronic stroke (onset > 3 months) unilateral cerebral lesion with hemiparesis or hemiplegia age of 20-80 years no epileptic spikes on the EEG brain stem or cerebellum stroke epilepsy aneurysm arteriovenous malformation psychiatric disease degenerative disease severe cognitive and communicative impairment or aphasia severe medical disease active medical problems metal implant in the body | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 0.0-999.0, Head Trauma Craniocerebral Injuries Crushing Skull Injury Head Injuries Head Injuries, Multiple Head Injuries, Closed Head Trauma,Closed Head Trauma Injury Head Trauma, Penetrating Head Injury, Minor Head Injury Major Head Injury, Open Injuries, Craniocerebral Injuries, Head Multiple Head Injury Trauma, Head Any patient who presents to Duke University Hospital with suspected head trauma and receives a brain CT scan will be considered for this study None | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-80.0, Intracerebral Hemorrhage, Hypertensive Traditional Chinese Medicine Greater than or equal to 18 years old while younger than 80 years old acute cerebral hemorrhage confirmed by brain CT scan within 6 to72 hours from onset GCS≥6 Sign the informed consent form Tests have confirmed that cerebral hemorrhage caused by brain tumor, blood diseases, cerebrovascular malformation (anomaly) or aneurysm, etc patients with Severe heart, liver and renal insufficiency Intolerance to traditional Chinese medicine (TCM), allergic constitution patients with severe cerebral hernia in the early onset Compliance is poor | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, CVA Patients arriving to the emergency room with decreased consciousness, severe headaches or dizziness Pregnant women | 2 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-70.0, Unilateral Headache Musculoskeletal Neck Pain Over the age of 18 Signs and symptoms consistent with cervicogenic headache (including unilateral headache, headache that improves or resolves as cervical disorder or lesion improves or resolves, headache that is made worse with cervical movement or sustained painful neck positions, reduced cervical range of motion Headache frequency of at least once a week for 3 months Bilateral headaches Non-musculoskeletal red flags Two or more positive neurologic signs indicative of nerve root compression Diagnosed with cervical spinal stenosis Bilateral upper extremity symptoms Symptoms indicative of central nervous system lesion History of whiplash injury within the previous 6 weeks Prior head or neck surgery Has received treatment for head or neck pain from any practitioner within the previous month Has received physical therapy or chiropractic treatment for head or neck pain within the previous 3 months | 1 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-65.0, Intracerebral Haemorrhage in Cerebellum Spontaneous intracerebral hemorrhage (Non aneurysmal or arteriovenous malformations which confirmed by cerebral arterial CT enhancement or DSA) Age 18-65 years, male or non-pregnant female GCS score at admission (4 to12) during the hospitalization, no urokinase and other hemostatic drugs were used except for etamsylate and vitamin K1 informed consent signed by the patient's family irregular lobulated hematoma (volume of hematoma can not be calculated accurately), such as intraventricular hemorrhage severe liver disease or impaired liver function pregnant or lactating women history of using anticoagulation or antiplatelet aggregation drug (including Cilostazol, aspirin, dipyridamole, heparin, low molecular weight heparin, hirudin, dabigatran, and warfarin) non-accepted informed consent | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-55.0, Migraine Is between the ages of 18 and 55 years Has been previously diagnosed as suffering from migraine, in accordance with the IHS-Classification (2nd) (with or without aura) Experiences at least 2 migraines per month, but less than 15 headache days per month (over the last 3 months) Has age of onset of migraine less than 50 years old Is able to distinguish migraines from other headaches (e.g. tension headache) Agrees to withhold usual migraine medications until after stimulation treatment with the GammaCore device Agrees to follow all of the requirements of the study, including follow-up visit requirements, and is sufficiently trained with respect to the operation of the GammaCore device and the data collection procedures Agrees to report use of the GammaCore device, study data, and any adverse device effects to the study center within 24 hours of treatment(s), and agrees to schedule an office visit 4-10 days after the third and final treatment, or when 6 weeks has passed, whichever comes first Is able to give written Informed Consent, or his/her legally authorized representative is available to give written Informed Consent Has a history of aneurysm, bleed, brain tumors or significant head trauma Has a lesion (including lymphadenopathy) at the therapy head placement site Has known or suspected severe atherosclerotic cardiovascular disease, carotid artery disease (e.g. bruits or history of TIA or CVA) or congestive heart failure (CHF) Has a history of epilepsy Has suspected or confirmed sepsis, or infection Has a clinically significant irregular heart rate or rhythm Is receiving pressors to maintain blood pressure Has a history of syncope Is currently implanted with an electrical and/or neurostimulator device, including but not limited to cardiac pacemaker, vagal neurostimulator, deep brain stimulator, spinal stimulator, bone growth stimulator, or cochlear implant Has been implanted with metal cervical spine hardware | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Cardiotoxicity HER2/Neu Positive Metastatic Malignant Neoplasm in the Brain Recurrent Breast Carcinoma Stage IV Breast Cancer AJCC v6 and v7 STEP 1 Patients must have metastatic breast cancer and be initiating within 7 days of step 1 registration or continuing trastuzumab?based HER-2 targeted therapy without concurrent anthracyclines in first or second line setting; patients may have brain metastasis; there is no limit for number of doses of HER-2 targeted therapy prior to registration; examples of eligible HER-2 targeted therapy Trastuzumab Trastuzumab + chemotherapy or hormonal therapy Trastuzumab + other HER-2 targeted agent with or without chemotherapy (such as pertuzumab) Ado-trastuzumab (Kadcyla) NOTE: Patients on lapatinib without trastuzumab are not eligible; planned treatment with concurrent HER-2 targeted therapy and anthracyclines is not permitted Patients must be at increased risk for cardiotoxicity defined by at least one of the following Previous anthracycline exposure, OR or more of the following risk factors for heart disease | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-65.0, Migraine Migraine patients who meet IHS for migraine with or without aura of both sexes 70 years 95 kg Any other type of headache then migraine without aura (except episodic tension-type headache < 1 day per week) Serious somatic or psychiatric disease Pregnancy Intake of daily medication (except oral contraceptives) Triptan non-responders | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-44.0, Plasma Volume Micronutrients Menstrual Cycle Female to 44 years of age General good health (does not have a known, ongoing health condition/medical issue that requires regular monitoring by a doctor or regular visits to the hospital) BMI 18.5-24.9 kg/m2 Regular menstrual cycle (26-35 days) Non-smoker Non-pregnant If pregnant before, ≥12 months since last pregnancy Known allergy to shellfish or iodine Blood pressure on the day of measurements is low or high (systolic blood pressure (SBP) <90 or ≥130 mmHg and/or diastolic blood pressure (DBP) <60 or ≥80 mmHg) Currently has low or high blood pressure (SBP <90 or ≥130 mmHg and/or DBP <60 or ≥80 mmHg), self-reported Current hypertension or previous hypertensive disorder in pregnancy (gestational hypertension or preeclampsia) Taking regular medication(s) (physician's prescribed medications for a health condition) Currently trying to conceive Currently breastfeeding Currently using hormonal birth control or used within last 3 months Used depot medroxyprogesterone acetate (DMPA) in the past 12 months Diagnosis of polycystic ovary syndrome | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-45.0, Hearing Loss Parturients having accidental dural puncture during epidural placement for labour analgesia Patients who give written informed consent to participate in the study Dural puncture with 17G Touhy needle with/out headache Postural headache after 24 hours of epidural Labouring women undergoing vaginal or Cesarean delivery For the control group, patients with no dural puncture during epidural placement Patients refusing to consent Dural puncture with spinal needle | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Benign Neoplasms Vascular Malformations, Brain Patients with brain tumor, meningeomas and vascular malformation Patients with signs of elevated intracranial pressure; History of kidney disease, History of heart disease | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 0.0-999.0, Aortopathies Thoracic Aortic Aneurysm Aortic Valve Disease Thoracic Aortic Disease Thoracic Aortic Dissection Thoracic Aortic Rupture Ascending Aortic Disease Descending Aortic Disease Ascending Aortic Aneurysm Descending Aortic Aneurysm Marfan Syndrome Loeys-Dietz Syndrome Ehlers-Danlos Syndrome Shprintzen-Goldberg Syndrome Turner Syndrome PHACE Syndrome Autosomal Recessive Cutis Laxa Congenital Contractural Arachnodactyly Arterial Tortuosity Syndrome Open to external enrollment Subjects with a genetic diagnosis of Marfan Syndrome (MDS), Loeys-Dietz Syndrome (LDS), or Vascular Ehlers-Danlos Syndrome (EDS); (Positive genetic testing or a previous cardiac study required to be eligible) Family members of eligible subjects (Only family members of subjects with syndromic diagnoses are eligible for external enrollment at this time) Closed to external enrollment Subjects with aortic disease including TAA* or dissection, aortic tortuosity, or aortic hypoplasia/stenosis (based on any cardiac imaging modality including echocardiography, CT, MRI, or angiography) Subjects with aortic valve disease (bicuspid, unicuspid, or tricuspid disease) Control subjects having tissue removed during a surgical procedure (e.g. coronary artery bypass graft surgery (CABG), cardiac transplant, etc.) • Inability or unwillingness to provide consent (assent when indicated) | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 11.0-15.0, Vascular Malformations Phase 1 Patient with slow-flow vascular malformation, regardless of clinical form, severity (clinical and imaging diagnosis), aged 11 to 15 years-old Patient with slow-flow vascular malformation, whatever its clinical form, its severity (clinical and imaging diagnosis), aged over 15 years-old Parents of a patient with slow-flow vascular malformation, regardless of clinical form, severity (clinical and imaging diagnosis), aged 11 to 15 years-old inclusive Patient affiliated to a social security scheme Patient having given his consent or for the minor whose legal representative has given written informed consent. Phase 2 Patient with slow-flow vascular malformation, regardless of clinical form, severity (clinical and imaging diagnosis), 11 to 15 years-old of age included Patient affiliated to a social security scheme Patient having given his consent or for the minor whose legal representative has given his informed consent For both phases: Pregnant or lactating women or girls Vulnerable persons Majors subject to a legal protection measure or unable to express their consent Phase 1: Patient or parent who does not speak the French language and therefore are unable to express themselves in the focus groups Patient under 11 years-old; Phase 2 : Patient who does not speak French and is therefore unable to complete quality of life questionnaires Patient under 11 or over 15 years-old | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 15.0-49.0, Family Size A household was considered eligible for the study if the following are met at least one married women with reproductive age group (15-49) year's child able to provide a consent and voluntary to participate in the study Cluster which has more than 30 married women. A household was excluded if the woman or her husband will not volunteer to participate in the study Married women who are not volunteer to provide informed consent Married women who are declared infertile | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Non-inflammatory Degenerative Joint Disease Osteoarthritis Avascular Necrosis Rheumatoid Arthritis Male and female ≥18 years Non-inflammatory degenerative joint disease including osteoarthritis and avascular necrosis, suitable for unilateral primary hip replacement Rheumatoid arthritis Correction of functional deformity Voluntary written Informed Consent obtained Pre-operative Prospect for recovery to independent mobility compromised by known coexistent medical problems Requiring revision hip replacement Requiring bilateral hip replacement Previous hip replacement (resurfacing or THR) on the contralateral side and whose outcome is achieving an Oxford Hip score <18 points Likely post-operative leg length inequality >5cm Neuromuscular disease affecting hip (Parkinson's, cerebral palsy, other spasticity) Primary or metastatic tumour involving this hip Loss of abductor musculature, poor bone stock, or poor skin coverage around the hip joint Previous organ transplant | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Labor Pain Satisfaction, Consumer Language Birth Depression Childbirth Problems Nulliparous and multiparous pregnant women 36 weeks gestation Somali-, Arabic-, Russian or Tigrinya-speaking Cannot communicate fluently in Swedish No contra-indications for vaginal birth Planned caesarean birth Not consenting to access to their birth records years old or younger | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-40.0, Postdural Puncture Headache Patient acceptance Pregnant female undergoing Elective caesarean section under spinal anesthesia Age 18-40 years old ASA I and ASA II Accepted mental state of the patient Patient refusal Contraindications to regional anesthesia as local infection, coagulopathy,….etc ASA Grade 3 and 4 Emergent caesarean section Inadequate temporal window Hypertensive disorders of the pregnancy Atrial fibrillation Significant fetal illness History of allergy to local anesthetics | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Chronic Migraine, Headache years old or older Chronic migraine (diagnosed as 15 or more headaches per month) Willing and able to provide consent Able to speak and read English headache disorder other than migraine change in preventive medications within 3 weeks prior to enrollment pain disorder other than migraine as a primary problem pregnant or planning pregnancy medical or psychiatric comorbidities likely to interfere with participation less than 7th grade reading proficiency | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-65.0, Headache Age 18 to 65 years Presenting chief complaint of headache, migraine, tension headache, cluster headache, or headache not otherwise specified Report of pain 4 using a standard 11-point numerical scale (0 to 10; 0=no pain and 10=worst possible pain) Age < 18 years or > 65 years Inability to provide informed consent Physical or mental disability hindering adequate response to assessment of pain Hemodynamic instability/medical condition requiring acute life-saving medical intervention Documented or suspected pregnancy or currently breastfeeding Known brain mass, intracranial hemorrhage, skull fracture Known allergy, hypersensitivity, or prior adverse reaction to acetaminophen, NSAIDs, diphenhydramine, or prochlorperazine Known contraindications to acetaminophen use Severe hepatic impairment, severe active liver disease Known contraindications to ketorolac/NSAID use | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Obstetric Complication Postpartum Hemorrhage Postpartum Endometritis Female Able to give consent Gestational age > 24 weeks Postpartum Placement of an IBT within the last 2 hours with plans for it to remain in situ for at least 2 hours Primary obstetrician amenable to proceeding with either method of management during the study period Age < 18 years old IBT removed within 2 hours of placement Chorioamnionitis Insufficient documentation of demographics, delivery outcomes, or peripartum events including postpartum hemorrhage, infectious outcomes | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 40.0-999.0, Acute Ischemic Stroke Men and women aged ≥40 years Acute ischemic stroke confirmed by computed tomography (CT) or magnetic resonance imaging (MRI) of the head Stroke onset within 24-48 hours* Systolic blood pressure between 140-200 mmHg and diastolic blood pressure between 80-120 mmHg Hemorrhagic stroke confirmed by CT or MRI of the head CT or MRI-diagnosed vascular malformation, tumor, abscess, or other major non-ischemic brain disease (e.g., multiple sclerosis) Extracranial or intracranial artery stenosis (≥70%) in both sides or the affected side based on imagine study Stroke caused by arteritis, migraine, vasospasm, or substance abuse Severe stroke (NIHSS score of ≥21) Coma (Glasgow Coma Scale [GCS] score <8) Preceding moderate or severe dependency (modified Rankin scale [mRS] score 3-5) Planned or probable revascularization (any angioplasty or vascular surgery) within 3 months after screening Intravenous thrombolytic therapy (such as intravenous rtPA) or mechanical thrombectomy Severe heart failure (NY Heart Association class III and IV) or left ventricular ejection fraction <35% | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 40.0-75.0, Cerebral Atherosclerosis Patients of either sex, aged 40-75 years. 2. Diagnosis of cerebral atherosclerosis based on the following three factors underlying vascular disease (atherosclerosis and/or arterial hypertension) and focal neurological signs and symptoms accompanied by nonspecific cerebral symptoms (i.e. headache, dizziness, noise in the head, impairment of memory, fatigue) ultrasound signs of cerebrovascular blood flow defects (on duplex scanning of the main artery of the head for 6 months before to study entry) 0-1.5T CT/MRT signs of structural changes in brain matter (subcortical and periventricular leukoaraiosis and/or focal changes in gray and white matter observed as postischemic cysts and/or lacunar infarcts, and/or diffuse atrophic changes observed as ventricular or subarachnoid enlargement). 3. Cognitive impairments (MoCA (Montreal Cognitive Assessment) <26). 4. Patients who have been on an unchanged standard medication regimen for cerebral atherosclerosis and arterial hypertension for the previous month. 5. Agreement to use a reliable method of birth control for the duration of the study. 6. Provision of signed patient information sheet and informed consent form to participate in the clinical trial A prior history of subarachnoid/parenchymatous/ventricular hemorrhage, brain neoplasm, or any other condition known to have caused the neurological dysfunction. 2. Ischemic stroke or any other cerebrovascular accident defined by the Modified Rankin Scale (mRs > 1), within 6 months prior to study entry . 3. Any known potential cardiac sources of embolism defined by TOAST as medium to high-risk. 4. Any previous (within 2 weeks prior to screening) or current signs of an acute infectious disease or exacerbation of a chronic infectious disease. 5. Prior history of CNS (central nervous system) disorders, including Inflammatory diseases of the CNS (G00-G09) Systemic atrophies primarily affecting central nervous system (G10-G13) Other degenerative diseases of the nervous system (G30-G32) Demyelinating diseases of the CNS (G35-G37). 6. Dementia (F00-F03). 7. Prior diagnosis of heart failure defined by the New York Heart Association classification (1964) as III or IV FC. 8. Hypothyroidism, diabetes mellitus, or other decompensated somatic disease. 9. Uncontrolled arterial hypertension: systolic blood pressure > 180 mm Hg and/or diastolic blood pressure > 110 mm Hg. 10. Decompensated disease of veins of lower extremities (e.g. varicose veins of lower extremities, thrombosis of deep veins, etc.). 11. Any other condition which, in the opinion of the investigator, prevents the patient from participating in the study. 12. Any known or suspected malignant neoplasm. 13. Allergy to/intolerance of any constituent of the medications used in the treatment. 14. Hereditary lactose intolerance. 15. Malabsorption syndrome (lactose intolerance), including congenital or acquired lactase deficiency or any other disaccharidase insufficiency, galactosemia. 16. Pregnancy, breast-feeding. 17. Prior history of non-adherence to a drug regimen, a psychiatric disorder, alcoholism, or drug abuse, which, in the opinion of the investigator, can compromise compliance with study protocol. 18. Use of any medicine listed in the section "Prohibited concomitant treatment" within 1 month preceding the in this study. 19. Participation in other clinical trials within the 3 months preceding the in this study. 20. Patient is related to the research personnel of the investigative site that are directly involved in the trial, or is the immediate relative of the investigator. The immediate relative includes husband/wife, parents, children or brothers (or sisters), regardless of whether they are natural or adopted. 21. Patient works for OOO "NPF "Materia Medica Holding" (i.e. is the company's employee, temporary contract worker or appointed official responsible for carrying out the research or is an immediate relative of the aforementioned) | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Headache, Migraine Hemorrhage Male or female over 18 years-old Patient presenting at the Emergency Service a non-traumatic severe headache lasting for less than 3 hours. The severity is defined as a VAS ≥ 6/10 Blood sample can be taken within 1 hour following the emergency admission VAS > 6 or Glasgow < 8 Signed and dated informed consent by patient, or trusted person, or family Patient presenting headache after head trauma Pregnant or breastfeeding women Patient with a pathology causing the elevation of PS100B's rate such as Alzheimer's disease, Creuzfeld-Jacob's disease, Multiple Sclerosis, cerebral tumour, trisomy 21, melanoma (diabetes excluded) Patient covered by social security regimen or equivalent Patient under guardianship (legal protection) Patient deprived of liberty by court or administrative order Any condition that could influence PS100B's dosage results according to the physician | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Pregnancy Diabetic women with confirmed GDM or at risk for this disease. Pregnancies > 10 weeks of gestation, primipara and multipara pregnancies < 10 weeks of gestation, congenital malformations of the fetus | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-50.0, Migraine Migraineurs(patients) age 18-50 years migraine with or without aura as defined by the third edition of the International Classification of Headache Disorders (ICHD-3 beta) migraine duration > 6 months episodic migraine feature headache (< 15 attacks/m) not any preventive medications for migraine 2. Control age 18-50 years no headache disorder requiring painkillers within the past year no more than moderate intensity of headache within the past year no headache disorder other than Infrequent episodic tension-type headache as defined by the ICHD-3 beta chronic migraine within last month (≥15 attacks/m) medication overuse headache as defined by ICHD-3 beta other comorbid disease that may affect vascular function (Hypertension, diabetes, hyperlipidemia, cerebral infarction, smoking etc) can not breath 20 L for 1 minute because of basal cardiopulmonary disease (chronic obstructive pulmonary disease, heart failure etc) a disease that can be exacerbated by elevated PCO2 in blood (Interstitial lung disease, amyotrophic lateral sclerosis etc) predicted to be unable to write the headache diary due to cognitive decline contraindications to MRI pregnancy refusal to informed consent | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 20.0-50.0, Tension-Type Headache Trigger Points being between 20 and 50 years of age, 2. diagnosed with CTTH according to the International Classification of Headache Disorders-3 (ICHD-3) beta 3. having at least one active TrP, and 4. having pain intensity greater than 2 cm on the Visual Analog Scale (VAS) subjects who have migraine, cluster headache, episodic tension-type headache, secondary headaches and facial pain, 2. subjects who used any medication, except simple analgesics, during treatment | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Migraine Chronic Migraine Episodic migraine with at least 5 headache days per month, episodic migraine and tension type headache with at least 5 migraine headache days per month, chronic migraine Stable prophylactic headache medication Stable non-medication headache prophylaxis (sports, relaxation techniques, …) Informed consent Other causes of headache, symptomatic headaches Other primary headaches such as Cluster headache, trigeminal neuralgia, idiopathic facial pain, new daily persistent headache Severe depression (more than 13 points in the Beck Depression inventory fast screen (BDI-FS) Drug or alcohol abuse Non-compliance, especially significant missing entries in the headache diaries Active psychosis | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Migraine Cluster Headache Trigeminal Autonomic Cephalgia Hemicrania Continua Paroxysmal Hemicrania SUNCT Short-Lasting Unilateral Neuralgiform Headache With Conjunctival Injection and Tearing Diagnosis of one of the following: a. Diagnosis of a primary headache disorder according to the International Headache Classification, including migraine with aura, migraine without aura, chronic migraine, tension headache, cluster headache, paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT), short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA), and hemicrania continua; b. Diagnosed by a pain medicine physician with lumbar radiculopathy (possibly including neuropathic features, nerve impingement on MRI, or electromyography (EMG) report suggestive of lumbar radiculopathy); or c. Healthy control subject with no history of debilitating headaches or debilitating back pain / radiculopathy pain, and no headaches or back pain within the previous 3 months Able to provide HIPAA authorization to share prior medical records/imaging Age 18 and older The following items the subject from all portions of the study: a. Known history of cardiovascular or neurovascular diseases. These diseases may carotid stenosis of >50%, vertebral stenosis, peripheral vascular disease, angina or myocardial infarction, stroke, or vascular malformations; b. History of brain tumors or epilepsy; c. Active pregnancy or lactation; d. Daily cigarette, tobacco or nicotine use; e. Life expectancy less than 1 year, co-existing disease or other characteristic that precludes appropriate diagnosis of headache or spine pain; f. Active drug / alcohol use or dependence that, in the opinion of the investigator, would interfere with adherence to study requirements; or g. Inability or unwillingness of subject to give informed consent (e.g., ward of the state) The following items the subject only from the capsaicin portion of the study: a. Known allergy to capsaicin or hot peppers The following items the subject only from the oxygen portion of the study: a. Pulmonary or other non-headache diseases that require the use of supplemental oxygen The following items the subject only from the cold water irrigation (ice water) portion of the study: a. Trauma, fractures, or congenital abnormalities of the soft palate | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 0.0-999.0, HIV Infections Drug Interactions Cardiovascular Diseases documented HIV-infection informed consent as documented by signature (Appendix Informed Consent Form) included in the SHCS and followed-up in the HIV Clinic in Lausanne or in Basel treatment with a HIV therapy including either once-daily ritonavir-boosted darunavir or dolutegravir (or others ARV drugs for the exploratory investigations) treatment with one or eventually 2 of the comedications of interest, i.e. amlodipine, atorvastatin or rosuvastatin (or any drug potentially involved in clinically relevant DDI for the exploratory investigations) Ability to comply with the study requirements Presence of severe comorbidities (i.e. cirrhosis (Child-Pugh score C), heart failure (NYHA 3-4), advanced kidney impairment (KDOQI 4-5)) which can substantially impact the pharmacokinetic of drugs and significantly confound the study results Presence of interacting non HIV comedications (i.e comedications with known, strong inhibitory or inducing effects on drug metabolizing cytochromes and drug transporters, which might significantly confound the study results) Participants incapable of jugement or participants under tutelage Known or suspected non-compliance, drug or alcohol abuse considered at risk to significantly confound the study results Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia of the participant Enrolment of the investigator, his/her family members, employees and other dependent persons Women who are pregnant or breastfeeding | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Cerebral Vasospasm Subarachnoid Hemorrhage Subjects 18 years Hospitalized in our intensive care unit Subarachnoid hemorrhage proven on CT angiogram Cerebral vasospasm proven on CT angiogram Pregnant women Minor Major under guardianship | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-999.0, Bone Loss, Alveolar Dental Implant Failure Nos Any healthy patient scheduled for an implant-supported restoration will be considered for in this study, independently of the implant and prosthetic protocols used general medical contraindications to oral surgery (American Society of Anesthesiologist, ASA, class III or IV) patients <18 years of age smoking habit (>10 cigarettes/day) sites with acute infection or requiring regenerative procedures Full Mouth Plaque Score Full Mouth Bleeding Score >25 % pregnant and lactating | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 18.0-75.0, Dermatomyositis, Adult Type Must understand the risks and the benefits/purpose of the study and provide signed and dated informed consent Must be 18 years at time of signing the informed consent form Willing to participate in all required evaluations and procedures in the study including the ability to swallow pills without difficulty Patients must have a diagnosis of DM based upon the characteristic cutaneous findings proposed by Sontheimer[6] and/or a skin biopsy consistent with DM Patients must be candidate for systemic therapy for their DM skin disease defined by inadequate response to aggressive sun protection along with the use of potent topical corticosteroids and/or immunomodulators Patients with a diagnosis of dermatomyositis on steroid-sparing agent and/or systemic steroids (maximum dose of prednisone 1mg/Kg) and still having cutaneous disease activity of at least 5 on the CDASI scale If on immunosuppressive treatments and/or steroids, patients must be on stable doses for at least 4 weeks (28 days) Patients must undergo age appropriate cancer screening Females of childbearing potential (FCBP) must have a negative pregnancy test at screening (day 0 of the study and every month throughout the study). While on investigational product and for at least 28 days after taking the last dose of investigational product Increasing or changing dose of topical therapy within 14 days of study day 0 (including but not limited to topical corticosteroids, tacrolimus, pimecrolimus) Increasing or changing systemic steroids dosing within 28 days of study day 0 Increasing or changing dosing for concurrent therapy agents within 28 days or 5 half-lives of the biologic agent, whichever is longer, before study day 0: methotrexate, azathioprine, mycophenolate mofetil, hydroxychloroquine, dapsone, leflunomide, cyclosporine, biologic agents (anti-TNFs), IVIG, rituximab History of any clinically significant (as determined by the investigators) cardiac, endocrinologic, pulmonary, neurologic, psychiatric, hepatic, renal, hematologic, immunologic, or other major uncontrolled disease Any condition, including the presence of laboratory abnormalities, which places the patient at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study Pregnant or breastfeeding Untreated Latent Mycobacterium tuberculosis infection or active tuberculosis infection as indicated by a positive Purified Protein Derivative (PPD) skin test or T-spot Any condition, including the presence of laboratory abnormalities that places the patient at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study Patients with acute dermatomyositis onset and rapid progression of muscle disease or significant systemic involvement including pulmonary diseases associated with DM Prior major surgery or major life-threatening medical illness within 2 weeks | 0 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount of blood in her right ventricle. NSGY evaluated her for spontaneous intraventricular hemorrhage with a concern for an underlying vascular malformation. Cerebral angiogram was done which showed abnormal vasculature with a draining vein from L temporal lobe penetrating deep white matter consistent with AVM. The patient did continue to have a headaches but they were improving with pain medication. The patient refused PT evaluation but was ambulating independently without difficulty. She was discharged to home with her husband on [**2155-12-6**]. | eligible ages (years): 0.0-0.596, Intraventricular Hemorrhage of Prematurity Gestational age less than or equal to 30 6/7 weeks at birth 2. Less than 3 hours from birth 3. Informed consent obtained from parent or legal guardian prior to reaching time point for randomization Presence of genetic/chromosomal abnormality, congenital hydrocephalus, congenital neuromuscular disorder, or other diagnosis determined to impact survival or generalizability of results 2. Unable to participate for any reason based on the decision of the principal investigator. 3. Infants born outside Winnie Palmer Hospital for Women and Babies | 0 |
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