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After revealing himself to be HIV positive in November 2015, Charlie Sheen returned to Today Tuesday morning, sharing an update on his life with the disease, reflecting on past regrets, and speaking out against a controversial treatment he sought in Mexico earlier this year.

During an interview with Today‘s Matt Lauer, Sheen revealed his biggest regrets concerning his life, career, and behavior. “I regret not using a condom one or two times when this whole thing happened,” he said. “I regret ruining Two and a Half Men. I regret not being more involved in my children’s lives growing up… But, we can only move forward from today, and they wouldn’t call it the past if it wasn’t.”

He further elaborated on the alternative treatment method he sought south of the border, one that made headlines for its unusual methodology. “That didn’t go so well. That man is a criminal; he’s a charlatan,” the 50-year old said, revealing that, while under Dr. Sam Chachoua’s care, the virus count in his bloodstream jumped from 0 to 7,000. “He’s hurting a lot of good and decent people.”

In January, Sheen visited The Dr. Oz Show to give an update on his health, revealing he was off his HIV medications ahead of traveling to Mexico for the alternative treatment which, according to the doctor, involved spending several months injecting himself with Sheen’s blood and using goat’s milk to help cure the actor’s HIV. Sheen previously noted their time together amounted to little more than a day, and denounced the doctor’s approach to curing him on Twitter.

Currently undergoing treatment as part of an FDA trial, which allowed the actor to declare himself “undetectable,” Sheen described his current healthcare routine as “one shot per week, as opposed to pills everyday,” noting the change is “not just physical, but it’s psychological… This is the future of treatment what I’m doing now.”

On his previous Today appearance, Sheen said he was diagnosed with HIV more than four years prior. “It’s a hard three letters to absorb. It’s a turning point in one’s life,” the actor said, admitting he’d spent more than $10 million to keep the condition secret as he endured various “shakedowns” over the years regarding his health. “What people forget is that that’s money they’re taking from my children… I trusted them and they were deep in my inner circle, and I thought they could be helpful. My trust turned to their treason.”

Sheen rose to prominence in the late 1980s, after roles in films like Platoon (1986), Wall Street (1987), and Major League (1989). He later made waves in 2011 after a public meltdown that resulted in his firing from the hit CBS series Two and a Half Men. The 50-year old later returned to TV on the FX sitcom Anger Management, which ran for 100 episodes between 2012 and 2014. Though it notched the most-watched premiere for a series in the network’s history, the show made headlines for the alleged on-set conflict between Sheen and costar Selma Blair, who left the series into its second season after reportedly clashing with the actor during production.

The actor will next appear alongside Whoopi Goldberg in the indie drama Nine Eleven, which will revolve around five people trapped in an elevator in the World Trade Center on Sept 11., 2001.

Watch Sheen’s full interview on Today in the video below.