"Cocaine toothache drops", 1885 advertisement of cocaine for <a href="https://en.wikipedia.org/wiki/toothache" class="extiw" title="en:toothache">dental pain</a> in children. United States.
<a href="https://en.wikipedia.org/wiki/User:KiloByte" class="extiw" title="en:User:KiloByte">KiloByte</a> at en.wikipedia
1885-03
"Available from many sources, this version (highest quality I've found) comes from [Encyclopædia Dramatica, with upload history lost due to shutdown/restoration of ED. The image is unaltered, thus its PD status is not in [question]"