Skeletal formulae of <a href="https://en.wikipedia.org/wiki/buprenorphine" class="extiw" title="w:buprenorphine">buprenorphine</a> (a mixed agonist–antagonist <a href="https://en.wikipedia.org/wiki/opioid_modulator" class="extiw" title="w:opioid modulator">opioid modulator</a>) and <a href="https://en.wikipedia.org/wiki/samidorphan" class="extiw" title="w:samidorphan">samidorphan</a> (a selective μ-<a href="https://en.wikipedia.org/wiki/opioid_antagonist" class="extiw" title="w:opioid antagonist">opioid antagonist</a>). Their combination is known as <b><a href="https://en.wikipedia.org/wiki/ALKS-5461" class="extiw" title="w:ALKS-5461">ALKS-5461</a></b> and is investigated as an adjunct to antidepressant therapy in <a href="https://en.wikipedia.org/wiki/treatment-resistant_depression" class="extiw" title="w:treatment-resistant depression">treatment-resistant depression</a>. Created with <a rel="nofollow" class="external text" href="http://www.chemdoodle.com">ChemDoodle 7.0.2</a> and <a rel="nofollow" class="external text" href="http://www.adobe.com/products/illustrator.html">Adobe Illustrator CC 2015</a>.
<a href="//commons.wikimedia.org/wiki/User:Vaccinationist" title="User:Vaccinationist">Vaccinationist</a>
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