Multiple sequence alignment of the growth hormone receptor (GHR) protein for Echimyidae, Capromyidae and outgroup rodents. Note: this alignment is best viewed in the <b>SVG</b> (<a href="//commons.wikimedia.org/wiki/Scalable_Vector_Graphics" class="mw-redirect" title="Scalable Vector Graphics">Scalable Vector Graphics</a>) format.
<p>All GHR protein sequences are written with respect to the first one (<i>Echimys chrysurus</i>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/AGE92351.1">NCBI accession AGE92351.1</a>), conventionally taken as a reference. Identical amino acid residues are indicated by a dash '-', gaps by a star '*', and missing information by a question mark '?'. Sites of the alignment are numbered according to the human GHR protein (<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/AAI36497.1">NCBI accession AAI36497.1</a>).
</p><p>The yellow rectangle on position 294 emphasizes the amino acid replacement of L (Leucine) by P (Proline, in red) which yields a diagnostic synapomorphy characterizing the subfamily Euryzygomatomyinae (in blue, genera <i>Trinomys</i>, <i>Euryzygomatomys</i>, and <i>Clyomys</i>).<sup id="cite_ref-1" class="reference"><a href="#cite_note-1">[1]</a></sup></p>
<div class="reflist" style="list-style-type: decimal;">
<ol class="references"><li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><cite style="font-style:normal">Fabre, Pierre-Henri (<span class="mw-formatted-date" title="2017-03-01">2017-03-01</span>). "<a rel="nofollow" class="external text" href="https://academic.oup.com/mbe/article/34/3/613/2739699/Mitogenomic-Phylogeny-Diversification-and">Mitogenomic Phylogeny, Diversification, and Biogeography of South American Spiny Rats</a>". <i>Molecular Biology and Evolution</i> <b>34</b> (3): 613–633. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093/molbev/msw261">10.1093/molbev/msw261</a>. <a href="https://en.wikipedia.org/wiki/International_Standard_Serial_Number" class="extiw" title="en:International Standard Serial Number">ISSN</a> <a rel="nofollow" class="external text" href="https://www.worldcat.org/issn/0737-4038">0737-4038</a>.</cite></span>
</li>
</ol></div>
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<cite style="font-style:normal">Fabre Pierre-Henri, Upham Nathan S., Emmons Louise H., Justy Fabienne, Leite Yuri L. R., Loss Ana Carolina, Orlando Ludovic, Tilak Marie-Ka, Patterson Bruce D., Douzery Emmanuel J. P. (<span class="mw-formatted-date" title="2017-03-01">2017-03-01</span>). "<a rel="nofollow" class="external text" href="https://academic.oup.com/mbe/article/34/3/613/2739699/Mitogenomic-Phylogeny-Diversification-and">Mitogenomic Phylogeny, Diversification, and Biogeography of South American Spiny Rats</a>". <i>Molecular Biology and Evolution</i> <b>34</b> (3): 613–633. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093/molbev/msw261">10.1093/molbev/msw261</a>. <a href="https://en.wikipedia.org/wiki/International_Standard_Serial_Number" class="extiw" title="en:International Standard Serial Number">ISSN</a> <a rel="nofollow" class="external text" href="https://www.worldcat.org/issn/0737-4038">0737-4038</a>.</cite>