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] | อาหารเมดิเตอร์เรเนียน
อาหารเมดิเตอร์เรเนียน () เป็นการคุมอาหารที่ได้แรงดลใจจากประเพณีการทานอาหารของชาวกรีก ชาวอิตาลีภาคใต้ และชาวสเปนที่พบในช่วงคริสต์ทศวรรษที่ 1940 และ 1950
หลักสำคัญรวมการทานน้ำมันมะกอก พืชวงศ์ถั่ว ข้าวกล้อง ผลไม้และผักเป็นจำนวนมาก ทานปลาพอประมาณจนถึงมาก ทานผลิตภัณฑ์นมโดยมากเป็นชีสและโยเกิร์ตพอประมาณ ดื่มไวน์พอประมาณ และทานผลิตภัณฑ์เนื้อสัตว์นอกจากปลาน้อย |
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] | อาหารเมดิเตอร์เรเนียน
มีหลักฐานบ้างว่า อาหารชนิดนี้ลดความเสี่ยงโรคหัวใจและการเสียชีวิตก่อนวัย
น้ำมันมะกอกอาจเป็นองค์ประกอบหลักที่ทำให้สุขภาพดี
มีหลักฐานเบื้องต้นว่า การทานน้ำมันมะกอกเป็นประจำอาจลดอัตราการตายโดยเหตุทั้งหมด (all-cause mortality) ลดความเสี่ยงมะเร็ง โรคหัวใจร่วมหลอดเลือด () ประสาทเสื่อม (neurodegeneration) และโรคเรื้อรังหลายอย่าง |
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ในปี 2013 องค์การการศึกษา วิทยาศาสตร์ และวัฒนธรรมแห่งสหประชาชาติ () ได้เพิ่มอาหารเมดิเตอร์เรเนียนเป็นมรดกทางวัฒนธรรมแห่งมนุษยชาติ (Representative List of the Intangible Cultural Heritage of Humanity) ของประเทศอิตาลี (เป็นผู้โปรโหมต) สเปน โปรตุเกส โมร็อกโก กรีซ ไซปรัส และโครเอเชีย |
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] | อาหารเมดิเตอร์เรเนียน
งานทบทวนวรรณกรรมปี 2017 พบหลักฐานว่า การทานอาหารนี้ลดความเสี่ยงโรคหัวใจร่วมหลอดเลือด มะเร็งโดยทั่วไป โรคทำให้ประสาทเสื่อม (neurodegenerative diseases เช่น โรคพาร์คินสันและโรคอัลไซเมอร์) โรคเบาหวาน และการเสียชีวิตก่อนวัย
งานทบทวนวรรณกรรมปี 2018 แสดงว่า อาหารอาจทำให้สุขภาพดีขึ้นโดยทั่วไป เช่น ลดความเสี่ยงโรคไม่ติดต่อ ลดค่าครองชีพ และลดค่าใช้จ่ายในระบบสาธารณสุข
งานทบทวนวรรณกรรมปี 2016 พบว่า ช่วยลดน้ำหนักเท่ากับการคุมอาหารแบบอื่น ๆ |
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งานทบทวนวรรณกรรมแบบคอเคลนปี 2013 พบหลักฐานที่จำกัดว่า อาหารนี้มีผลดีต่อปัจจัยเสี่ยงของโรคหัวใจร่วมหลอดเลือด
โดยเปรียบเทียบอาหารเมดิเตอร์เรเนียน อาหารเวแกน (เลี่ยงผลิตภัณฑ์สัตว์) อาหารผักผลไม้ (เลี่ยงเนื้อสัตว์) อาหารไกลซีมิกต่ำ (ควบคุมการเปลี่ยนระดับซูโครสในเลือด) อาหารคาร์โบไฮเดรตต่ำ อาหารใยอาหารสูง อาหารโปรตีนสูง และอาหารกลุ่มควบคุม
งานวิจัยนี้สรุปว่า อาหารเมดิเตอร์เรเนียน อาหารไกลซีมิกต่ำ อาหารคาร์โบรไฮเดรตต่ำ อาหารโปรตีนสูง มีประสิทธิผลปรับปรุงตัวบ่งชี้โรคหัวใจร่วมหลอดเลือดและโรคเบาหวาน และมีหลักฐานจำกัดว่า อาหารผักผลไม้ช่วยควบคุมระดับซูโครสและไขมันในเลือดที่ไม่เกี่ยวกับผลลดน้ำหนัก |
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แต่งานทบทวนวรรณกรรมปี 2016 รอบคอบกว่า คือได้ยกปัญหาคุณภาพของงานปริทัศน์เป็นระบบและงานวิเคราะห์อภิมานในอดีตที่ตรวจผลของอาหารเมดิเตอร์เรเนียนต่อปัจจัยเสี่ยงโรคหัวใจร่วมหลอดเลือด
และเน้นความจำเป็นให้สร้างมาตรฐานงานวิจัยให้ดีกว่านี้
โดยพบหลักฐานการป้องกันโรคหลอดเลือดของอาหารเมดิเตอร์เรเนียนว่า "จำกัดและต่าง ๆ กันมาก"
งานทบทวนวรรณกรรมต่อ ๆ มาก็ได้สรุปเหมือนกันว่า อาหารช่วยปรับปรุงปัจจัยโรคหัวใจร่วมหลอดเลือด เช่น ความดันโลหิตสูงและโรคหัวใจต่าง ๆ |
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] | อาหารเมดิเตอร์เรเนียน
อาหารชนิดนี้บ่อยครั้งอ้างว่ามีประโยชน์เพราะมีไขมันอิ่มตัวต่ำ มีไขมันไม่อิ่มตัวแบบมีพันธะคู่เดี่ยว () และใยอาหารสูง
ประโยชน์โดยหลักเชื่อว่ามาจากน้ำมันมะกอก ซึ่งมีไขมันไม่อิ่มตัวแบบมีพันธะคู่เดี่ยวมาก
ที่เด่นที่สุดคือกรดโอเลอิกซึ่งก็กำลังวิจัยว่ามีผลดีต่อสุขภาพหรือไม่
องค์กรความปลอดภัยอาหารยุโรป () ปี 2012 ได้อนุมัติให้อ้างผลต่อสุขภาพของน้ำมันมะกอก ว่ามีโพลีฟีนอล (polyphenol) ที่ป้องกันการออกซิไดส์ไขมันในเส้นเลือด
และช่วยควบคุมระดับคอเลสเตอรอลในเลือดแบบไม่ดี () เพราะทดแทนไขมันอิ่มตัวในอาหารด้วยกรดโอเลอิก |
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] | อาหารเมดิเตอร์เรเนียน
งานวิเคราะห์อภิมานปี 2014 สรุปว่า การทานน้ำมันมะกอกมากขึ้นสัมพันธ์กับอัตราความตายโดยเหตุทั้งหมดที่ลดลง กับปัญหาโรคหัวใจร่วมหลอดเลือดที่ลดลง และกับความเสี่ยงโรคหลอดเลือดสมองที่ลดลง แต่การเพิ่มทานกรดไขมันไม่อิ่มตัวแบบมีพันธะคู่เดี่ยว (MUFA) ที่มาจากพืชผสมกับสัตว์ไร้ผลที่มีนัยสำคัญ |
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] | อาหารเมดิเตอร์เรเนียน
งานวิเคราะห์อภิมาน 2 งานในปี 2014 พบว่า อาหารนี้สัมพันธ์กับความเสี่ยงโรคเบาหวานชนิด 2 ที่ลดลง
เหมือนกับที่พบในงานปี 2017 ดังที่กล่าวมาแล้ว |
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] | อาหารเมดิเตอร์เรเนียน
งานวิเคราะห์อภิมานปี 2008 พบว่า การทานอาหารแบบเมดิเตอร์เรเนียนอย่างเข้มสัมพันธ์กับความเสี่ยงตายเพราะมะเร็งที่ลดลง 6%
งานทบทวนวรรณกรรมปี 2017 พบว่า มีผลลดอัตราการเกิดมะเร็ง
งานปริทัศน์เป็นระบบและงานวิเคราะห์อภิมานปี 2014 พบว่า การทานอาหารแบบเมดิเตอร์เรเนียนสัมพันธ์กับความเสี่ยงตายเพราะมะเร็งที่ลดลง
มีหลักฐานเบื้องต้นว่า การทานน้ำมันมะกอกเป็นประจำอาจลดความเสี่ยงการเกิดโรคมะเร็ง |
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] | อาหารเมดิเตอร์เรเนียน
งานปริทัศน์เป็นระบบปี 2016 พบว่าการยึดทานอาหารเมดิเตอร์เรเนียนได้ดีกว่าสัมพันธ์กับการทำงานทางประชาน/ความคิดอ่านที่ดีกว่า
แต่ก็ไม่ชัดเจนว่าเป็นความสัมพันธ์โดยเหตุหรือไม่ |
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ตามงานปริทัศน์เป็นระบบปี 2013 การทานอาหารเมดิเตอร์เรเนียนแบบเข้มสัมพันธ์กับความเสี่ยงโรคอัลไซเมอร์ที่ลดลงและความเสื่อมทางประชานที่ช้ากว่า
ส่วนงานปริทัศน์เป็นระบบอีกงานหนึ่งในปี 2013 ก็ได้สรุปอย่างเดียวกัน และพบด้วยว่าสำหรับผู้พิการทางประชานในระดับอ่อน ๆ (mild cognitive impairment) การทานอาหารสัมพันธ์กับความเสี่ยงแย่ลงกลายเป็นโรคอัลไซเมอร์ที่ลดลง
แต่ผู้วิจัยก็ยอมรับว่า งานที่ทำในเรื่องนี้ยังมีจำนวนน้อย |
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แต่งานที่ศึกษาความสัมพันธ์เช่นนี้เป็นงานศึกษาแบบสังเกต จึงไม่ได้พิสูจน์ความเป็นเหตุและผล |
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] | อาหารเมดิเตอร์เรเนียน
เพราะอาหารชนิดนี้ปกติจะรวมผลิตภัณฑ์ที่มีกลูเตน เช่น พาสตาและขนมปัง การทานอาหารมากขึ้นอาจมีส่วนให้อัตราการเกิดความผิดปกติเกี่ยวกับกลูเตน (gluten-related disorders)
สูงขึ้น
แม้จะมี "อาหารเมดิเตอร์เรเนียน" ที่ต่าง ๆ กันในบรรดาประเทศและชุมชนต่าง ๆ ในบริเวณเมดิเตอร์เรเนียนเพราะความต่างกันทางชาติพันธุ์ ทางวัฒนธรรม ทางเศรษฐกิจ และทางศาสนา แต่อาหารก็มักมีองค์ประกอบสำคัญอย่างเดียวกันนอกเหนือไปจากการออกกำลังกายอย่างสม่ำเสมอ รวมทั้ง |
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] | อาหารเมดิเตอร์เรเนียน
ขนาดที่ทานต่าง ๆ บางครั้งจะแสดงเป็นพีระมิดอาหารเมดิเตอร์เรเนียน
ในบรรดาแคลอรีที่ได้แต่ละวันจากอาหาร จะได้จากไขมันทั้งหมดระหว่าง 25%-35% โดยได้ไขมันอิ่มตัว 8% หรือน้อยกว่านั้น
อิตาลีภาคเหนือมักใช้น้ำมันหมูและเนยเพื่อปรุงอาหาร ส่วนน้ำมันมะกอกใช้กับสลัดและการปรุงผัก
ทั้งในแอฟริกาเหนือและตะวันออกกลาง ไขมันหลักตามประเพณีก็คือไขมันจากหางแกะและเนยใส (เนยเจียว) |
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] | อาหารเมดิเตอร์เรเนียน
นักชีววิทยาแอนเซ็ล คียส์ (Ancel Keys) และภรรยาคือนักเคมีชาวอเมริกันมาร์กาเร็ต (Margaret Keys) ได้พัฒนาอาหารเมดิเตอร์เรเนียนขึ้นให้คล้ายกับ "รูปแบบอาหารปกติของครีต กรีซที่เหลือโดยมาก และอิตาลีภาคใต้ในต้นคริสต์ทศวรรษ 1960"
แม้จะได้ตีพิมพ์เป็นครั้งแรกก็ต่อเมื่อปี 1975
และก็ไม่ได้การยอมรับจนกระทั่งคริสต์ทศวรรษ 1990 |
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] | อาหารเมดิเตอร์เรเนียน
ข้อมูลเป็นกลางที่แสดงว่าเป็นอาหารถูกสุขภาพ มาจากงานศึกษาทางวิทยาการระบาดในเมืองเนเปิลส์และนครมาดริด
ซึ่งงานศึกษาในประเทศ 7 ประเทศต่อมาได้ยืนยันเริ่มตั้งแต่ปี 1970
แล้วตีพิมพ์การวิเคราะห์เป็นหนังสือในปี 1980
รูปแบบอาหารซึ่งรู้จักดีที่สุดเริ่มปรากฏในวรรณกรรมตั้งแต่กลางคริสต์ทศวรรษ 1990 เป็นต้น |
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] | อาหารเมดิเตอร์เรเนียน
อาหารนี้ปรากฏกว่าขัดกับหลักโภชนาการทั่วไปอย่างหนึ่ง คือ แม้คนแถบทะเลเมดิเตอร์เรเนียนจะทานไขมันเป็นจำนวนมาก แต่กลับมีอัตราการเกิดโรคหัวใจร่วมหลอดเลือดน้อยกว่าประเทศอื่น ๆ รวมทั้งสหรัฐ ที่ทานไขมันประมาณเดียวกัน
ความขัดแย้งเช่นนี้ก็พบในการทานอาหารของชาวฝรั่งเศสด้วย (เป็น French Paradox) |
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] | อาหารเมดิเตอร์เรเนียน
นักเขียนชาวอิตาลี Giacomo Castelvetro ได้โปรโหมตการทานอาหารมีสลัดมากตั้งแต่สมัยฟื้นฟูศิลปวิทยาต้น ๆ (ปี 1614) แล้ว
ในปี 2011 อาหารนี้ได้กลายเป็นอาหารแฟชั่นนิยมอย่างหนึ่งที่โปรโหมตเพื่อลดน้ำหนัก |
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] | อาหารเมดิเตอร์เรเนียน
ในปี 2018 อาหารที่คนเมดิเตอร์เรเนียนได้ทานตามประเพณีกำลังเสื่อมไปเพราะเริ่มทานอาหารเหมือนกับชนอื่น ๆ มากขึ้นและเพราะการผลิตอาหารตามโลกาภิวัตน์ |
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] | อาหารเมดิเตอร์เรเนียน
เมื่อแอนเซ็ล คียส์ได้ศึกษาและกำหนดลักษณะอาหารเมดิเตอร์เรเนียน เพื่อเปรียบเทียบกับนิสัยการกินของสหรัฐและประเทศพัฒนาแล้วโดยมากในเวลานั้น นักวิชาการบางท่านได้เรียกมันว่า "อาหารคนจน"
ประเทศโปรตุเกสก็รวมอยู่ในงานศึกษานี้ด้วยตามนักกินมืออาชีพท่านหนึ่งที่ได้พบกับคียส์ และคียส์ก็พิจารณาโปรตุเกสว่า มีอาหารเมดิเตอร์เรเนียนแบบไม่เจือปนที่ดีสุด
แต่ผู้ปกครองเผด็จการของประเทศในเวลานั้น ไม่ต้องการให้ใช้ชื่อประเทศเนื่องกับอาหารที่เขาเข้าใจว่า เป็นอาหารของคนจน |
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] | อาหารเมดิเตอร์เรเนียน
แม้ปัจจุบันชื่อนี้ก็ไม่นิยมใช้ในโปรตุเกส
หลังจากอาหารเมดิเตอร์เรเนียนได้เกิดชื่อเสียง จึงมีงานศึกษาที่ตรวตสอบผลดีต่อสุขภาพของ "อาหารแบบแอตแลนติก" ซึ่งคล้ายกับอาหารนี้ แต่มีปลา อาหารทะเล และผักใบมากกว่า
ศาสตราจารย์ในเรื่องประวัติอาหารและการกินผู้หนึ่งจึงกล่าวว่า อาหารโปรตุเกสจริง ๆ เป็นอาหารแบบแอตแลนติก |
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] | ไขมันไม่อิ่มตัว
ไขมันไม่อิ่มตัว () เป็นกรดไขมันที่มีพันธะคู่อย่างน้อยหนึ่งคู่ภายในโซ่กรดไขมัน
โซ่กรดไขมันเรียกว่า มีพันธะคู่เดี่ยว (monounsaturated) ถ้ามีพันธะคู่หนึ่งคู่ และมีพันธะคู่หลายคู่ (polyunsaturated) ถ้ามีพันธะคู่มากกว่านั้น
ในที่ ๆ เกิดพันธะคู่ โซ่คาร์บอนจะไร้อะตอมไฮโดรเจน
ดังนั้น ไขมันอิ่มตัวที่ไม่มีพันธะคู่เลย ก็จะมีไฮโดรเจนยึดกับคาร์บอนเป็นจำนวนมากที่สุด และดังนั้น จึง "อิ่มตัว" เพราะมีไฮโดรเจนเต็ม
ในเมแทบอลิซึมระดับเซลล์ โมเลกุลไขมันไม่อิ่มตัวมีพลังงาน (คือ แคลอรี) น้อยกว่าไขมันอิ่มตัวเท่า ๆ กัน
กรดไขมันยิ่งไม่อิ่มตัวเท่าไร (คือมีพันธะคู่มากขึ้น ๆ) ก็จะไวต่อกระบวนการ lipid peroxidation
คือหืน/มีกลิ่นเหม็นง่ายยิ่งขึ้นเท่านั้น
สารต้านอนุมูลอิสระเช่นวิตามินสามารถป้องกันไขมันไม่อิ่มตัวจากกระบวนการนี้ |
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] | ไขมันไม่อิ่มตัว
พันธะคู่ดังว่าอาจเป็นไอโซเมอร์แบบ"ซิส" (cis) หรือ"ทรานส์" (trans) ขึ้นอยู่กับรูปร่าง (molecular geometry) ของมัน
ไอโซเมอร์แบบซิสมีอะตอมไฮโดรเจนที่ข้างเดียวกันกับพันธะคู่
เทียบกับแบบทรานส์ ซึ่งมีอะตอมไฮโดรเจนด้านตรงกันข้ามกับพันธะคู่ ("ดูเพิ่มที่ ไขมันทรานส์")
ไขมันอิ่มตัวมักใช้ผลิตอาหารสำเร็จรูปเพราะมันหืนยากกว่า และแข็งกว่าไขมันไม่อิ่มตัวที่อุณหภูมิห้อง
ไขมันไม่อิ่มตัวมีจุดหลอมเหลวต่ำ ดังนั้น มันจึงเพิ่มสภาพไหล/ความยืดหยุ่นได้ของเยื่อหุ้มเซลล์ |
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] | ไขมันไม่อิ่มตัว
แม้จะแทนไขมันอิ่มตัวในอาหารด้วยไขมันไม่อิ่มตัวทั้งแบบมีพันธะคู่เดี่ยวและมีพันธะคู่หลายคู่ได้
แต่ไม่ควรแทนด้วยไขมันไม่อิ่มตัวแบบทรานส์
การแทนไขมันเช่นนี้ช่วยลดระดับคอเลสเตอรอลโดยรวมและคอเลสเตอรอลแบบไม่ดี () ในเลือด
ยกเว้นไขมันไม่อิ่มตัวแบบทรานส์เพราะรูปร่างสามมิติ (stereochemistry) ของพันธะคู่ทำให้โซ่คาร์บอนมักจะหมุนตามแกนพันธะให้เป็นเส้นตรง (linear conformation) ซึ่งทำให้ไขมันอัดแน่นได้ เช่นที่พบในตะกรัน/คราบไขมันในท่อเลือดแดง (atheroma, plaque)
ส่วนพันธะคู่แบบซิสจะมีรูปร่างซึ่งทำให้โมเลกุลงอ ทำให้ไขมันอัดแน่นไม่ได้ (ดูรูปในตาราง) |
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] | ไขมันไม่อิ่มตัว
แม้ไขมันไม่อิ่มตัวแบบมีพันธะคู่หลายคู่ (PUFA) จะช่วยป้องกันภาวะหัวใจเสียจังหวะ แต่งานศึกษาหญิงหลังวัยหมดระดูที่ทานไขมันค่อนข้างต่ำแสดงว่า PUFA สัมพันธ์กับโรคหลอดเลือดแดงหล่อเลี้ยงหัวใจแข็ง (coronary atherosclerosis) ที่แย่ลง เทียบกับไขมันไม่อิ่มตัวแบบมีพันธะเดี่ยว (MUFA)
นี่อาจเป็นเพราะ PUFA ไวต่อกระบวนการ lipid peroxidation ซึ่งสามารถป้องกันได้ด้วยวิตามินอี |
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] | ไขมันไม่อิ่มตัว
ตัวอย่างของกรดไขมันไม่อิ่มตัวรวมทั้ง palmitoleic acid, กรดโอเลอิก, myristoleic acid, linoleic acid และ arachidonic acid
อาหารที่มีไขมันไม่อิ่มตัวรวมทั้งอาโวคาโด เมล็ดถั่ว น้ำมันมะกอก และน้ำมันพืชบางอย่างเช่น น้ำมันผักกาด (canola)
ส่วนเนื้อสัตว์มีทั้งไขมันอิ่มตัวและไม่อิ่มตัว |
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] | ไขมันไม่อิ่มตัว
แม้ไขมันไม่อิ่มตัวโดยทั่วไปจะพิจารณาว่าถูกสุขภาพมากกว่าไขมันอิ่มตัว
องค์การอาหารและยาสหรัฐ () แนะนำว่า ไม่ควรทานไขมันไม่อิ่มตัวเป็นพลังงานเกินกว่า 30% ในแต่ละวัน
อาหารโดยมากมีทั้งไขมันอิ่มตัวและไม่อิ่มตัว
แต่โฆษณามักจะระบุเพียงอย่างเดียว คือไขมันที่มีมากกว่า
ดังนั้น น้ำมันพืชที่โฆษณาว่าเป็นไขมันไม่อิ่มตัว เช่น น้ำมันมะกอก ก็มีไขมันอิ่มตัวด้วย
ความชุกของการไม่ตอบสนองต่ออินซูลิน (insulin resistance) จะลดลงถ้าทานอาหารที่มีไขมันไม่อิ่มตัวแบบมีพันธะคู่เดี่ยว (MUFA) โดยเฉพาะกรดโอเลอิก/omega-9 มากกว่า แต่จะมากขึ้นเมื่อทานอาหารมีไขมันมีพันธะคู่หลายคู่ (PUFA) โดยเฉพาะ arachidonic acid/omega-6 และไขมันอิ่มตัว เช่น arachidic acid มากกว่า
ความสัมพันธ์กับอาหารเช่นนี้สมมุติว่า รองจากความสัมพันธ์กับการอักเสบ (inflammation) ซึ่งสามารถควบคุมได้เป็นบางส่วนโดยลดเพิ่มการทานกรดไขมันโอเมกา-3/6/9 โอเมกา-3 และ 9 เชื่อว่า ต้านการอักเสบ และโอเมกา-6 สนับสนุนการอักเสบ แต่ก็มีปัจจัยอื่น ๆ อีกด้วย เช่น การทาน polyphenol และการออกกำลังกายจะช่วยต้านการอักเสบ
แม้ไขมันทั้งแบบสนับสนุนและต้านการอักเสบอาจจำเป็นต่อร่างกาย แต่อาหารอเมริกันโดยมากมีโอเมกา-6 มาก ซึ่งเพิ่มการอักเสบและเพิ่มการไม่ตอบสนองต่ออินซูลิน
อย่างไรก็ดี มีงานศึกษาต่อจากนั้นซึ่งแสดงนัยตรงกันข้าม คือพบว่า ไขมันมีพันธะคู่หลายคู่ช่วยป้องกันการไม่ตอบสนองต่ออินซูลิน |
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] | ไขมันไม่อิ่มตัว
เยื่อหุ้มเซลล์ของสัตว์เลี้ยงลูกด้วยนมมีสัดส่วนกรดไขมันไม่อิ่มตัวมีพันธะคู่หลายคู่ (, กรดไขมันโอเมกา-3) มากกว่าของสัตว์เลื้อยคลาน
ส่วนสัตว์ปีกมีสัดส่วนเช่นกันเมื่อเทียบกับสัตว์เลื้อยคลาน แต่มีโอเมกา-3 1/3 น้อยกว่าเทียบกับโอเมกา-6 เมื่อเทียบกับสัตว์เลี้ยงลูกด้วยนมตามขนาดร่างกาย
องค์ประกอบกรดไขมันเช่นนี้ทำให้เยื่อหุ้มเซลล์ยืดหยุ่นได้มากกว่าซึ่งไอออนหลายอย่างซึมผ่านได้รวมทั้ง H และ Na และต้องใช้ทรัพยากรมากกว่าเพื่อดำรงรักษา
ซึ่งอ้างว่า เป็นเหตุสำคัญที่ทำให้สัตว์เลี้ยงลูกด้วยนมและสัตว์ปีกมีเมแทบอลิซึมสูงและมีเลือดอุ่นอันเกิดขึ้นด้วยกัน |
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แต่เยื่อหุ้มเซลล์ก็อาจเป็นไขมันอิ่มตัวแบบมีพันธะคู่หลายคู่เพื่อตอบสนองต่อความหนาวเป็นประจำได้เช่นกัน
คือปลาจะมีไขมันไม่อิ่มตัวทั้งแบบมีพันธะคู่เดี่ยวและพันธะคู่หลายคู่ที่เยื่อหุ้มเซลล์มากขึ้นเมื่อสิ่งแวดล้อมเย็นลง เพื่อให้เยื่อยืดหยุ่นได้และทำงานได้ในอุณหภูมิที่ต่ำกว่า |
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] | ภูเขาแพ็กดู
ภูเขาแพ็กดู () หรือ ภูเขาฉางไป๋ () เป็นภูเขาไฟมีพลังชนิดกรวยภูเขาไฟสลับชั้น ตั้งอยู่บนชายแดนระหว่างจีนกับเกาหลีเหนือ มีความสูง 2,744 เมตร และเป็นภูเขาที่สูงที่สุดในเทือกเขาฉางไป๋ และเทือกเขาแพ็กดูแทกัน รวมถึงเป็นภูเขาที่สูงที่สุดในคาบสมุทรเกาหลีและภาคตะวันออกเฉียงเหนือของจีนอีกด้วย ชาวเกาหลีให้ความสำคัญแก่ภูเขาไฟและทะเลสาบที่แอ่งยุบปากปล่องมาก เนื่องจากถือว่าเป็นบ้านของจิตวิญญาณของประเทศ |
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ทะเลสาบปล่องภูเขาไฟซึ่งอยู่ที่แอ่งยุบปากปล่องของภูเขานี้มีชื่อว่าทะเลสาบสวรรค์ เกิดจากการปะทุของภูเขาไฟใน ค.ศ. 946 ซึ่งปะทุประมาณ 100–120 ตารางกิโลเมตรของเทฟรา ซึ่งเป็นการปะทุที่ใหญ่และรุนแรงที่สุดในรอบ 5,000 ปี (ใกล้ชิดกับการปะทุของไมนอส, การปะทุของ Hetepe ของทะเลสาบ Taupo ใน ค.ศ. 180, การปะทุในปี ค.ศ. 1257 ของภูเขา Salamas ใกล้ภูเขารินจานี, การปะทุในปี ค.ศ. 1815 ของเขาตัมโบรา |
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เป๊กตุ้น (เสียชีวิต ค.ศ. 207) มีชื่อในสำเนียงจีนกลางว่า ท่าตุ้น () เป็นตัวละครในวรรณกรรมจีนอิงประวัติศาสตร์เรื่องสามก๊กที่มีตัวตนจริงในประวัติศาสตร์ยุคสามก๊ก เป็นผู้นำชนเผ่าอูหฺวันในปลายยุคราชวงศ์ฮั่นตะวันออกของจีน เป๊กตุ้นเป็นพันธมิตรของขุนศึกอ้วนเสี้ยวและอ้วนซงบุตรชายผู้สืบทอดตำแหน่งของของอ้วนเสี้ยว |
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เป๊กตุ้นเป็นญาติผู้น้องของชิวลี่จฺวีผู้่นำชนเผ่าอูหฺวัน หลังจากชิวลี่จวีเสียชีวิตราวต้นทศวรรษ 190 เป๊กตุ้นได้สืบทอดตำแหน่งเป็นผู้นำเผ่าอูหฺวันคนใหม่ เพราะบุตรชายของชิวลี่จฺวีชื่อโหลวปาน (樓班) ขณะนั้นอายุยังน้อยเกินไป เป๊กตุ้นไม่เพียงปกครองชนเผ่าอูหฺวันในเมืองเลียวไส (遼西郡 "เหลียวซีจวิ้น"; ปัจจุบันคือบริเวณอำเภอหลูหลง มณฑลเหอเป่ย์) แต่ยังปกครองชนเผ่าอูหฺวันในเมืองโย่วเป่ยผิง (右北平; ปัจจุบันคือบริเวณเมืองถางชาน มณฑลเหอเป่ย์) เมืองยีหยง (漁陽 "ยฺหวีหยาง"; ปัจจุบันคือบริเวณเขตมี่ยฺหวิน กรุงปักกิ่ง) และเมืองซ่างกู่ (上谷; ปัจจุบันคือบริเวณเขตเหยียนชิ่ง กรุงปักกิ่ง) |
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ตลอดทศวรรษ 190 เป๊กตุ้นสนับสนุนขุนศึกอ้วนเสี้ยวในการต่อสู้กับกองซุนจ้านเพื่อช่วงชิงความเป็นใหญ่ในภาคเหนือของจีน เพื่อตอบแทนการสนับสนุนของเป๊กตุ้น อ้วนเสี้ยวได้มอบตราตั้งและเกียรติยศแก่เป๊กตุ้นในนามของพระเจ้าเหี้ยนเต้ซึ่งเป็นจักรพรรดิแต่ในนามของราชวงศ์ฮั่นตะวันออก |
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หลังจากอ้วนเสีัยวเสียชีวิตในปี ค.ศ. 202 อ้วนซงบุตรชายและผู้สืบทอดตำแหน่งของอ้วนเสี้ยวยังคงความสัมพันธ์ฉันมิตรกับชนเผ่าอูหฺวัน เมื่ออ้วนซงพ่ายแพ้ให้กับโจโฉที่เป็นศัตรูของบิดาจำต้องหนีขึ้นไปทางเหนือและเข้าหลบภัยภายใต้การคุ้มครองของเป๊กตุ้นและเผ่าอูหฺวัน เป๊กตุ้นพยายามช่วยเหลืออ้วนซงในการกู้พื้นที่ทางตอนเหนือของจีนคืนจากโจโฉแต่ไม่ประสบผลสำเร็จ ในปี ค.ศ. 207 โจโฉยกทัพเข้ารบกับอ้วนซงและชนเผ่าอูหฺวัน กว่าที่ชนเผ่าอูหฺวันจะรู้ว่าโจโฉยกทัพมาโจมตีก็ช้าเกินไปแต่คงยังสามารถรวบรวมทหารได้หลายพันมารบกับข้าศึก ทัพทั้งสองฝ่ายปะทะกันในยุทธการที่เขาเป๊กลงสาน ใกล้เมืองหลิวเซีย (柳城 "หลิ่วเฉิง"; ปัจจุบันอยู่ทางตะวันตกเฉียงใต้ของเมืองเฉาหยาง มณฑลเหลียวหนิง) ระหว่างการรบ เป๊กตุ้นถูกจับตัวโดยหน่วย "ทหารเสือดาว" (虎豹騎) ที่นำโดยโจซุน ลูกพี่ลูกน้องของโจโฉ และภายหลังได้ถูกประหารโดยเตียวเลี้ยว ขุนพลของโจโฉ |
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จังหวัดรยังกัง () เป็นจังหวัดของเกาหลีเหนือ มีพรมแดนติดกับจีนทางตอนเหนือ ฮัมกย็องเหนือทางทิศตะวันออก ฮัมกย็องใต้ทางทิศใต้ และชากังทางทิศตะวันตก จังหวัดรยังกังเกิดขึ้นในปี 1954 จากการแยกจากจังหวัดฮัมกย็องใต้ มีเมืองหลวงของจังหวัดอยู่ที่เฮยซัน ในการเรียกของเกาหลีใต้ จังหวัดรยังกังจะถูกเรียกว่า "จังหวัดยังกัง" () |
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] | จังหวัดรยังกัง
จังหวัดรยังกังถูกแบ่งจากประเทศจีนโดยแม่น้ำยาลู่และแม่น้ำตูเมนซึ่งต้นกำเนิดแม่น้ำทั้งสองอยู่ที่ภูเขาแพ็กดูที่เป็นที่เคารพนับถือโดยทั้งชาวเกาหลีและชาวแมนจูเรียจากตำนานที่บอกว่าเป็นแหล่งกำเนิดของแต่ละคน เกาหลีเหนือได้บอกว่าคิม จ็อง-อิลเกิดค่ายต่อต้านคอมมิวนิสต์ที่ภูเขานั้น ชายแดนระหว่างจีนและเกาหลีเหนือที่ ทางตะวันออกของภูเขานี้เป็นที่ที่แห้งแล้ง ห่างไกล และภูเขาที่แทบจะไม่มีลาดตระเวน ทำให้เป็นหนึ่งในเส้นทางสำคัญที่ผู้ลี้ภัยจากเกาหลีเหนือผ่านไปที่ประเทศจีน แต่อย่างไรก็ตามผู้ลี้ภัยส่วนใหญ่ถึงแม้จะอาศัยที่จังหวัดนี้ มักจะเลือกที่จะข้ามแม่น้ำตูเมน |
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] | กรดไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยว
ในสาขาชีวเคมีและโภชนาการ กรดไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยว ( ตัวย่อ MUFA) เป็นกรดไขมันที่มีพันธะคู่เดี่ยวในโซ่กรดไขมัน โดยอะตอมคาร์บอนที่เหลือจะมีพันธะเดี่ยว
เทียบกับกรดไขมันไม่อิ่มตัวแบบมีพันธะคู่หลายคู่ (polyunsaturated fatty acid, PUFA) ที่มีพันธะคู่มากกว่าหนึ่งคู่ |
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] | กรดไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยว
โมเลกุลของกรดไขมันเป็นลูกโซ่ยาว มีกลุ่มแอลคิล (alkyl) ที่ปลายข้างหนึ่งและกลุ่มกรดคาร์บอกซิลิกที่ปลายอีกข้างหนึ่ง
ความหนืดและจุดหลอมเหลวของกรดไขมันจะเพิ่มขึ้นเมื่อมีพันธะคู่น้อยลง
ดังนั้น MUFA จึงมีจุดหลอมเหลวสูงกว่า PUFA เพราะมีพันธะคู่น้อยกว่า และมีจุดหลอมเหลวต่ำกว่าไขมันอิ่มตัว (ไม่มีพันธะคู่) เพราะมีพันธะคู่มากกว่า
เป็นของเหลวที่อุณหภูมิห้องและกึ่งของแข็งในตู้เย็นโดยมีโครงสร้างแบบ isotopic lattice |
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] | กรดไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยว
กรดไขมันแบบนี้ที่สามัญรวมทั้งกรดปาลมิโทลีอิก (palmitoleic acid 16:1 n−7), cis-vaccenic acid (18:1 n−7) และกรดโอเลอิก (18:1 n−9)
กรดปาลมิโทลีอิกมีคาร์บอน 16 อะตอม พันธะคู่แรกอยู่ห่างจากกลุ่มเมทิล (methyl group) 7 อะตอมคาร์บอน และห่างจากปลายคาร์บอกซิล 9 อะตอมคาร์บอน
กรดสามารถต่อให้เป็น cis-vaccenic acid ซึ่งมีคาร์บอน 18 อะตอม
ส่วนกรดโอเลอิกมีคาร์บอน 18 อะตอมโดยมีพันธะคู่แรกอยู่ห่างจากกรดคาร์บอกซิลิก 9 อะตอมคาร์บอน
ภาพแสดงโมเลกุลของกรดโอเลอิกทั้งแบบ Lewis structure และแบบจำลอง 3 มิติ |
988847#3 | [
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] | กรดไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยว
ไขมันชนิดนี้ป้องกันโรคหัวใจร่วมหลอดเลือดเพราะทำให้เยื่อหุ้มเซลล์ยืดหยุ่นได้ง่ายกว่าไขมันแบบอิ่มตัว แต่ไขมันก็เสื่อมได้ง่ายกว่าเพราะกระบวนการ lipid peroxidation
งานศึกษาขนาดใหญ่คือ KANWU พบว่า การเพิ่มทานไขมันไม่อิ่มตัวแบบมีพันธะคู่เดี่ยวและลดทานไขมันอิ่มตัว ทำให้ร่างกายตอบสนองต่ออินซูลินได้ดีขึ้น แต่ก็ต่อเมื่อทานไขมันทั้งหมดน้อย
แม้ก็มีกรดไขมันชนิดนี้บางอย่าง (คล้ายกับไขมันอิ่มตัว) ที่ทำให้ร่างกายไม่ตอบสนองต่ออินซูลิน เทียบกับกรดไขมันไม่อิ่มตัวแบบมีพันธะคู่หลายคู่ที่อาจช่วยป้องกันภาวะเช่นนี้ |
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] | กรดไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยว
งานศึกษาได้แสดงว่า การแทนไขมันอิ่มตัวด้วยไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยวในอาหาร สัมพันธ์กับการเผาพลังงานเพิ่มขึ้นทั้งเมื่อออกกำลังและเมื่อพักผ่อน
เมื่อทานอาหารที่มีกรดโอเลอิกมากกว่า พลังงานที่เผาเมื่อออกกำลังกายจะสูงกว่าเมื่อทานอาหารที่มีกรดปาลมิติก (palmitic acid)
งานศึกษายังแสดงอีกด้วยว่า การทานไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยวจะทำให้โกรธและหงุดหงิดน้อยลง |
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] | กรดไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยว
อาหารที่มีไขมันไม่อิ่มตัวแบบมีพันธะคู่เดี่ยวจะลดคอเลสเตอรอลที่ไม่ดี ()
และอาจเพิ่มคอเลสเตอรอลที่ดี () |
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] | กรดไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยว
ระดับกรดโอเลอิกพร้อมกับกรดไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยวอื่น ๆ ในเยื่อหุ้มเซลล์ของเม็ดเลือดแดงสัมพันธ์กับความเสี่ยงมะเร็งเต้านม
และ saturation index (SI) ของเยื่อหุ้มเซลล์ก็สัมพันธ์ในเชิงลบกับความเสี่ยงมะเร็งเต้านม
การมีไขมันอิ่มตัวมีพันธะคู่เดี่ยวและค่า SI ต่ำในเยื่อหุ้มเซลล์ของเม็ดเลือดแดงเป็นตัวบ่งชี้มะเร็งเต้านมสำหรับหญิงหลังวัยหมดระดู
ตัวแปรทั้งสองนี้ขึ้นอยู่กับฤทธิ์ของเอนไซม์ delta-9 desaturase (Δ9-d) |
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ส่วนในเด็ก การทานน้ำมันแบบไม่อิ่มตัวมีพันธะคู่เดี่ยวสัมพันธ์กับรูปแบบไขมันในเลือดที่ดีกว่า |
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] | กรดไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยว
อาหารเมดิเตอร์เรเนียนมีไขมันไม่อิ่มตัวแบบมีพันธะคู่เดี่ยวสูง
คนในประเทศบริเวณเมดิเตอร์เรเนียนบริโภคไขมันทั้งหมดมากกว่าคนในประเทศยุโรปเหนือ แต่ไขมันโดยมากเป็นกรดไขมันไม่อิ่มตัวแบบมีพันธะคู่เดี่ยวจากน้ำมันมะกอก และกรดไขมันโอเมกา-3 จากปลา ผัก และเนื้อสัตว์บางชนิดเช่นลูกแกะ โดยบริโภคไขมันอิ่มตัวน้อยมาก
งานทบทวนวรรณกรรมปี 2017 พบหลักฐานว่า การทานอาหารนี้ลดความเสี่ยงโรคหัวใจร่วมหลอดเลือด มะเร็งโดยทั่วไป โรคทำให้ประสาทเสื่อม (neurodegenerative diseases เช่น โรคพาร์คินสันและโรคอัลไซเมอร์) โรคเบาหวาน และการเสียชีวิตก่อนวัย
งานทบทวนวรรณกรรมปี 2018 แสดงว่า อาหารอาจทำให้สุขภาพดีขึ้นโดยทั่วไป เช่น ลดความเสี่ยงโรคไม่ติดต่อ ลดค่าครองชีพ และลดค่าใช้จ่ายในระบบสาธารณสุข |
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] | กรดไขมันไม่อิ่มตัวมีพันธะคู่เดี่ยว
ไขมันชนิดนี้พบในเนื้อสัตว์เช่นเนื้อแดง ผลิตภัณฑ์นมที่ไม่เอาส่วนผสมออก เมล็ดถั่ว และผลไม้ไขมันสูงเช่นมะกอกและอาโวคาโด
น้ำมันมะกอกเป็นไขมันไม่อิ่มตัวแบบมีพันธะคู่เดี่ยว 75%
น้ำมันเมล็ดทานตะวันแบบมีกรดโอเลอิกสูงมีไขมันไม่อิ่มตัวแบบมีพันธะคู่เดี่ยว 85%
ส่วนน้ำมันเมล็ดผักกาด (Canola oil) และมะม่วงหิมพานต์มีไขมันไม่อิ่มตัวแบบมีพันธะคู่เดี่ยว 58%
ไขมันวัวเป็นไขมันไม่อิ่มตัวแบบมีพันธะคู่เดี่ยวครึ่งหนึ่ง
และมันหมู 40%
แหล่งอาหารอื่นรวมทั้งน้ำมันอาโวคาโด น้ำมันแมคาเดเมีย น้ำมันเมล็ดองุ่น น้ำมันถั่วลิสง น้ำมันงา น้ำมันข้าวโพด ข้าวโพดคั่ว ข้าวสาลีไม่ขัดสี ธัญพืช น้ำมันถั่วอัลมอนด์ น้ำมันเมล็ดทานตะวัน น้ำมันเมล็ดกัญชง น้ำมันเมล็ดชาจีน ("Camellia oleifera") |
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] | ไขมันไม่อิ่มตัวมีพันธะคู่หลายคู่
ไขมันไม่อิ่มตัวมีพันธะคู่หลายคู่ () เป็นไขมันที่ประกอบด้วยโซ่ไฮโดรคาร์บอนที่มีพันธะคู่ของคาร์บอนกับคาร์บอนสองคู่หรือมากกว่านั้น
พบโดยหลักในเมล็ดถั่ว เมล็ดพืช ปลา น้ำมันเมล็ดพืช และหอยนางรม
ชื่อมีคำว่า "ไม่อิ่มตัว" ก็เพราะโมเลกุลไขมันมีอะตอมไฮโดรเจนน้อยกว่าจำนวนมากที่สุดที่เป็นไปได้ (ซึ่งก็จะไม่มีพันธะคู่เลย)
อาจเป็นไอโซเมอร์ทางโครงสร้าง (conformational isomerism) แบบ "ซิส" (cis) หรือ "ทรานส์" (trans) ขึ้นอยู่กับการจัดเรียงพันธะคู่ |
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] | ไขมันไม่อิ่มตัวมีพันธะคู่หลายคู่
ไขมันอิ่มตัวมีโซ่ไฮโดรคาร์บอนซึ่งเรียงแถวได้ง่าย ๆ
ส่วนโซ่ไฮโดรคาร์บอนของไขมันไม่อิ่มตัวแบบทรานส์จะเรียงแถวได้ง่ายกว่าแบบซิส แต่ก็ยังไม่เท่ากับไขมันอิ่มตัว
ดังนั้น โดยทั่วไป ไขมันไม่อิ่มตัวแบบซิสมีจุดหลอมเหลวต่ำสุด ไขมันไม่อิ่มตัวแบบทรานส์รองลงมา และไขมันอิ่มตัวมีจุดหลอมเหลวสูงสุด |
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] | ไขมันไม่อิ่มตัวมีพันธะคู่หลายคู่
ตำแหน่งพันธะคู่ของคาร์บอนกับคาร์บอนภายในโซ่กรดคาร์บอกซิลิก จะระบุเป็นอักษรกรีก
อะตอมคาร์บอนที่ใกล้กลุ่มคาร์บอกซิลมากที่สุดเรียกว่าคาร์บอน"อัลฟา" ถัดไปเรียกว่าคาร์บอน"บีตา" เป็นต้น
อะตอมคาร์บอนในกลุ่มเมธิล (methyl group) ท้ายสุดของโซ่ไฮโดรคาร์บอนเรียกว่าคาร์บอน "โอเมกา" เพราะเป็นอักษรสุดท้ายของชุดตัวอักษร
กรดไขมันโอเมกา-3 มีพันธะคู่ห่างจากคาร์บอนโอเมกา 3 คาร์บอน เทียบกับกรดไขมันโอเมกา-6 ที่มีพันธะคู่ห่างจากคาร์บอนโอเมกา 6 คาร์บอน (ดูรูป) |
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] | ไขมันไม่อิ่มตัวมีพันธะคู่หลายคู่
แม้ไขมันจะน่าสนใจในเรื่องโภชนาการมากที่สุด แต่ไขมันก็สามารถประยุกต์ใช้ในด้านอื่น ๆ อีกด้วย
น้ำมันชักแห้ง (drying oil) ซึ่งเกิดโพลีเมอร์เมื่อได้รับออกซิเจนแล้วกลายเป็นฝ้าแข็ง ก็เป็นไขมันไม่อิ่มตัวมีพันธะคู่หลายคู่เช่นเดียวกัน
ที่สามัญที่สุดก็คือ น้ำมันเมล็ดฝ้าย น้ำมันยางเคลือบไม้ของจีน (tung oil จาก "Vernicia fordii") น้ำมันเมล็ดดอกป๊อปปี้ น้ำมันกะเพราปรุงอาหารของเกาหลี (perilla oil จาก "Perilla frutescens") และน้ำมันวอลนัต
น้ำมันเหล่านี้ทั้งหมดสามารถใช้ทำสีและน้ำมันขัดเงา |
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] | ไขมันไม่อิ่มตัวมีพันธะคู่หลายคู่
ในงานวิจัยเบื้องต้น กรดไขมันโอเมกา-3 จากสาหร่าย ปลา และอาหารทะเลพบว่า ลดความเสี่ยงเนื้อหัวใจตายเหตุขาดเลือด (myocardial infarction)
ส่วนงานศึกษาเบื้องต้นอื่น ๆ พบว่า กรดไขมันโอเมกา-6 จากต้นทานตะวันและคำฝอยอาจลดความเสี่ยงโรคหัวใจร่วมหลอดเลือด () |
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] | ไขมันไม่อิ่มตัวมีพันธะคู่หลายคู่
กรดไขมันโอเมกา-3 ทั้งแบบโซ่ยาวและสั้นไม่สัมพันธ์กับความเสี่ยงมะเร็งเต้านมอย่างสม่ำเสมอ
docosahexaenoic acid (DHA) เป็นกรดไขมันไม่อิ่มตัวแบบมีพันธะคู่หลายคู่กลุ่มโอเมกา-3 ซึ่งสามัญที่สุดในเยื่อหุ้มเม็ดเลือดแดง การได้ DHA มากสัมพันธ์กับความเสี่ยงมะเร็งเต้านมที่ลดลง
และสัมพันธ์กับการทำงานทางประชานและทางพฤติกรรมที่ดีขึ้น
DHA ยังสำคัญยิ่งต่อเนื้อเทาในสมองของมนุษย์ ต่อการทำงานของจอตา และต่อการสื่อประสาท
ยังมีงานวิจัยเบื้องต้นที่กำลังตรวจการทานกรดไขมันไม่อิ่มตัวแบบมีพันธะคู่หลายคู่ว่าสัมพันธ์กับการเกิดอะไมโอโทรฟิก แลเทอรัล สเกลอโรซิส ซึ่งเป็นโรคเซลล์ประสาทสั่งการหรือไม่ |
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งานศึกษาเชิงเปรียเทียบได้แสดงความสำคัญของการทานกรดไขมันโอเมกา-6/โอเมกา-3 ให้ถูกสัดส่วน คือแสดงว่าการทานในอัตราส่วนน้อยกว่า 4:1 อาจมีผลต่อสุขภาพ |
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ผลงานปี 2013 ซึ่งประเมินหลักฐานจากปี 1966-1973 ขัดกับคำแนะนำทั่วไปว่า การแทนไขมันอิ่มตัวด้วยกรดลิโนลีอิก (linoleic acid) มีผลดีต่อสุขภาพ เพราะพบว่า ผู้ร่วมการทดลองซึ่งทำอย่างนี้กลับมีอัตราการตายจากเหตุทั้งหมด จากโรคหลอดเลือดเลี้ยงหัวใจ และจากโรคหัวใจร่วมหลอดเลือดในระดับสูงขึ้น
แต่นักวิทยาศาสตร์จำนวนมากก็คัดค้านงานศึกษานี้
จึงเป็นงานที่จุดชนวนการอภิปรายทั่วโลกเรื่องการแนะนำให้แทนไขมันอิ่มตัวด้วยไขมันไม่อิ่มตัวแบบมีพันธะคู่หลายคู่ |
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การให้เพิ่มทานไขมันไม่อิ่มตัวแบบมีพันธะคู่หลายคู่ไม่ลดโรค/ความผิดปกติเกี่ยวกับการตั้งครรภ์ เช่น ความดันโลหิตสูง หรือโรคพิษแห่งครรภ์ระยะก่อนชัก แต่อาจเพิ่มระยะการตั้งครรภ์เล็กน้อยและลดการคลอดก่อนกำหนด
คณะผู้เชี่ยวชาญในสหรัฐและยุโรปแนะนำว่า หญิงตั้งครรภ์หรือผู้กำลังให้นมบุตรควรทานไขมันไม่อิ่มตัวแบบมีพันธะคู่หลายคู่เพิ่มขึ้นจากปกติ เพื่อเพิ่มไขมัน ให้กับทารก |
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การทดลองทางคลินิกแบบสังเกตพบว่า ความสัมพันธ์ระหว่างการทานไขมันไม่อิ่มตัวแบบมีพันธะคู่หลายคู่กับมะเร็งไม่สม่ำเสมอ ต่างกันโดยปัจจัยการเกิดมะเร็งหลายอย่าง รวมทั้งเพศและความเสี่ยงทางพันธุกรรม
งานศึกษาบางงานพบความสัมพันธ์ะรหว่างการทานกรดไขมันโอเมกา-3 มากกว่าหรือมีในเลือดมากกว่า กับความเสี่ยงมะเร็งบาองอย่างที่ลดลง รวมทั้งมะเร็งเต้านมและมะเร็งลำไส้ใหญ่ แต่งานอื่น ๆ ก็ไม่พบความสัมพันธ์ |
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] | ลิพิดเปอร์ออกซิเดชัน
กระบวนการ ลิพิดเปอร์ออกซิเดชัน () เป็นการเสื่อมสภาพของลิพิดเพราะกระบวนการออกซิเดชัน
ที่อนุมูลอิสระ "ขโมย" อิเล็กตรอนจากลิพิดของเยื่อหุ้มเซลล์แล้วทำให้เซลล์เสียหาย
เกิดบ่อยที่สุดกับกรดไขมันไม่อิ่มตัวมีพันธะคู่หลายคู่ () เพราะพันธะคู่มีสะพาน methylene (-CH2-) ในระหว่างที่มีอะตอมไฮโดรเจนซึ่งไวปฏิกิริยามาก
กระบวนการนี้มีสามขั้นตอนเหมือนกับปฏิกิริยาอนุมูลอิสระอื่น ๆ คือ ระยะเริ่มต้น (initiation) ระยะแพร่กระจาย (propagation) และยุติ (termination)
ผลผลิตของปฏิกิริยานี้ เรียกว่า ลิพิดเปอร์ออกไซด์ (lipid peroxide) หรือ lipid oxidation product (LOP) |
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] | เซลล์ประสาทสั่งการ
เซลล์ประสาทสั่งการ
เป็นเซลล์ประสาทที่มีตัวอยู่ในคอร์เทกซ์สั่งการ (motor cortex) ในก้านสมอง หรืออยู่ในไขสันหลัง และส่งแกนประสาท/แอกซอนไปยังไขสันหลัง หรือนอกไขสันหลัง เพื่อควบคุมอวัยวะปฏิบัติงาน (effector) โดยตรงหรือโดยอ้อม อวัยวะหลัก ๆ ก็คือกล้ามเนื้อและต่อม
มีเซลล์สองชนิดคือเซลล์ประสาทสั่งการบน () และเซลล์ประสาทสั่งการล่าง ()
แอกซอนจาก UMN จะไปสุดที่อินเตอร์นิวรอนในไขสันหลัง แต่บางครั้งก็จะไปสุดที่ LMN โดยตรง
ส่วนแอกซอนจาก LMN จะส่งกระแสประสาทจากไขสันหลังไปยังอวัยวะปฏิบัติการ
LMN ยังแบ่งได้อีกสามอย่าง คือ เซลล์ประสาทสั่งการอัลฟา เซลล์ประสาทสั่งการบีตา และเซลล์ประสาทสั่งการแกมมา |
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คำว่า เซลล์ประสาทสั่งการ ปกติจะจำกัดหมายถึง เซลล์ประสาทสั่งการล่าง () ที่ส่งประสาทนำออก (efferent nerve) ไปยังกล้ามเนื้อโดยตรง |
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เซลล์ประสาทสั่งการเดียวอาจสื่อประสาทไปยังใยกล้ามเนื้อหลายเส้น และใยกล้ามเนื้อเส้นเดียวอาจได้รับศักยะงานเป็นจำนวนมากแม้ในช่วงที่กล้ามเนื้อกระตุกเพียงครั้งเดียว
ดังนั้น ถ้ากระแสประสาท/ศักยะงานใหม่มาถึงก่อนที่การกระตุกจะสิ้นสุดลง ก็อาจกระตุกซ้อนเป็นแบบบวกกัน (summation) หรือเป็นการเกร็งกล้ามเนื้อที่คงยืน (tetanic contraction)
ในแบบบวกกัน กล้ามเนื้อจะได้การกระตุ้นซ้ำ ๆ จนกระทั่งว่า ศักยะงานที่ได้ต่อ ๆ มาจากระบบประสาทกาย (somatic nervous system) จะมาถึงก่อนการกระตุกจะสิ้นสุดลง
จึงกระตุกซ้อนกันโดยมีแรงมากกว่ากระตุกแค่ครั้งเดียว
ส่วนการเกร็งกล้ามเนื้อที่คงยืนมาจากการกระตุ้นอย่างต่อเนื่องและถี่มาก คือศักยะงานจะมาถึงในอัตราสูงจนกระทั่งแยกการกระตุกต่างหาก ๆ จากกันไม่ได้ ทำให้เกร็งเพิ่มขึ้นเรื่อย ๆ จนถึงระดับสูงสุด |
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] | เซลล์ประสาทสั่งการ
เซลล์ประสาทสั่งการจะเริ่มพัฒนาขึ้นตั้งแต่ระยะต้น ๆ ของตัวอ่อน และพัฒนาต่อไปจนถึงวัยเด็ก
ในท่อประสาท (neural tube) เซลล์จะแบ่งออกตามแกน ventral-dorsal
แอกซอนของเซลล์จะเริ่มปรากฏในอาทิตย์ที่ 4 จากเขต ventral ตามแกน ventral-dorsal คือจาก basal plate |
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] | เซลล์ประสาทสั่งการ
homeodomain
ที่มีบทบาทในพัฒนาการนี้เรียกว่า motor neural progenitor domain (pMN)
ยีน transcription factor
ที่เกี่ยวข้องรวมทั้ง Pax6, OLIG2, Nkx6.1 และ Nkx6.2 โดยมีโปรตีน sonic hedgehog (จากยีน Shh) เป็นตัวควบคุม
ยีน OLIG2 สำคัญที่สุดเพราะโปรโหมตการแสดงออกของยีน ซึ่งเป็นเหตุให้วัฏจักรเซลล์ยุติ ตลอดจนโปรโหมต transcription factor อื่น ๆ ที่สัมพันธ์กับพัฒนาการของเซลล์ประสาทสั่งการ |
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] | เซลล์ประสาทสั่งการ
การกำหนดรายละเอียดของเซลล์จะเพิ่มขึ้นเมื่อ retinoic acid, fibroblast growth factor, Wnts และ TGFb รวมเข้ากับ Hox transcription factor ต่าง ๆ
ซึ่งมีอยู่ 13 อย่าง และเมื่อบวกกับสัญญาณที่เซลล์ได้ ก็จะเป็นตัวกำหนดว่า เซลล์ประสาทสั่งการจะมีลักษณะเป็น ventral หรือ dorsal มากกว่า
ในลำกระดูกสันหลัง Hox 4-11 จะแยกเซลล์ออกเป็น motor column 5 ส่วน
ตามตารางดังต่อไปนี้ |
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] | เซลล์ประสาทสั่งการ
เซลล์ประสาทสั่งการบน () เกิดที่คอร์เทกซ์สั่งการ (motor cortex) ใน precentral gyrus
คอร์เทกซ์สั่งการปฐมภูมิ (primary motor cortex) ประกอบด้วยเซลล์เบ็ตซ์ ซึ่งเป็นรูปแบบหนึ่งของเซลล์พีระมิด
แอกซอนจากเซลล์ประสาทเหล่านี้ส่งลงมาตาม corticospinal tract (ลำเส้นใยประสาทจากเปลือกสมองไปยังไขสันหลัง) |
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] | เซลล์ประสาทสั่งการ
ลำเส้นใยของเนื้อขาว (white matter tracts) เป็นมัดแอกซอนที่ใช้ส่งกระแสประสาทจำนวนมาก ๆ
ลำเส้นใยอยู่ที่ไขสันหลังและปรากฏเป็นสีขาวเนื่องจากปลอกไมอีลินที่หุ้มแอกซอน
แม้จะมีทั้งเส้นประสาทนำออกและเส้นประสาทนำเข้า เส้นประสาทนำออกจะส่งสัญญาณจากไขสันหลังไปยังอวัยวะปฏิบัติการเท่านั้น
ลำเส้นใยเช่นนี้ยังเป็นแหล่งกำเนิดของเซลล์ประสาทสั่งการล่าง ()
มีลำเส้นใยของเนื้อขาวสำหรับเซลล์ประสาทสั่งการ 7 เส้นหลัก ๆ ในไขสันหลัง ดังต่อไปนี้ |
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] | เซลล์ประสาทสั่งการ
เซลล์ประสาทสั่งการล่าง () เกิดที่ไขสันหลังและส่งกระแสประสาทไปยังอวัยวะปฏิบัติการไม่ว่าจะโดยตรงหรือโดยอ้อม
อวัยวะปฏิบัติการที่เป็นเป้าหมายมีหลายอย่าง แต่ในระบบประสาทกาย นี่จะเป็นใยกล้ามเนื้อ
มี LMN 3 หมวดแบ่งตามเป้าหมายการส่งสัญญาณคือ |
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] | เซลล์ประสาทสั่งการ
เซลล์ประสาทสั่งการร่างกาย (somatic motor neurons) เกิดที่ระบบประสาทกลาง (CNS) และส่งแอกซอนไปยังกล้ามเนื้อโครงร่าง
(เช่น กล้ามเนื้อที่แขนขา ท้อง และ) ซึ่งมีหน้าที่เคลื่อนไหวร่างกาย
หมวดย่อยของนิวรอนเหล่านี้รวมทั้ง เซลล์ประสาทส่งออกอัลฟา (alpha efferent neuron) และ
มีชื่อว่า "นำออก" ก็เพราะส่งกระแสประสาทจากระบบประสาทกลาง () ไปยังระบบประสาทส่วนปลาย () |
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] | เซลล์ประสาทสั่งการ
นอกจากจะหดเกร็งกล้ามเนื้อในอำนาจจิตใจแล้ว เซลล์ประสาทสั่งการอัลฟายังทำให้กล้ามเนื้อตึง (muscle tone) คือกล้ามเนื้อออกแรงแบบไม่ได้หดเกร็งอยู่ตลอดเพื่อต้านการถูกยืดออก
เมื่อกล้ามเนื้อยืดออก เซลล์ประสาทรับความรู้สึกใน muscle spindle
ก็จะรับรู้การยืดแล้วส่งสัญญาณไปยัง CNS ซึ่งก็จะสั่งให้เซลล์ประสาทส่งออกอัลฟาในไขสันหลังหดเกร็งกล้ามเนื้อคือ extrafusal muscle fiber ต้านการยืดกล้ามเนื้อเพิ่ม
เป็นกระบวนการที่เรียกว่า stretch reflex
ปัจจัยที่ควบคุมเซลล์ประสาทสั่งการล่างรวมทั้ง |
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] | เซลล์ประสาทสั่งการ
จุดต่อระหว่างเซลล์ประสาทสั่งการกับใยกล้ามเนื้อเป็นไซแนปส์พิเศษที่เรียกว่า แผ่นเชื่อมประสาทสั่งการและกล้ามเนื้อ (Neuromuscular junction, NMJ)
เมื่อได้การกระตุ้นพอ เซลล์ประสาทสั่งการก็จะหลั่งสารสื่อประสาทแอซิทิลโคลีน () จากปลายแอกซอน (axon terminal) ออกจากถุงไซแนปส์ (synaptic vesicle) ภายในเซลล์ที่เข้าเชื่อมกับเยื่อหุ้มเซลล์
แล้วโมเลกุล Ach ที่หลั่งออกนอกเซลล์ก็จะเข้ายึดกับหน่วยรับแอซิทิลโคลีนหลังไซแนปส์ (postsynaptic receptor) ที่แผ่นปลายประสาทสั่งการ (motor end plate)
เมื่อหน่วยรับ 2 หน่วยยึดเข้ากับ Ach แล้ว ช่องไอออนหนึ่งช่องก็จะเปิดปล่อยให้ไอออนโซเดียมไหลเข้าในเซลล์หลังไซแนปส์ได้
ซึ่งทำให้เซลล์ลดขั้วแล้วจุดชนวนศักย์ของแผ่นปลายประสาทเคลื่อนไหว (end-plate potential)
ซึ่งกระตุ้นหลอดฝอยที (T tubule) ของเยื่อหุ้มเส้นใยกล้ามเนื้อ (sarcolemma) แล้วทำให้ sarcoplasmic reticulum ปล่อยไอออนแคลเซียมในเซลล์
ซึ่งเป็นเหตุให้ใยกล้ามเนื้อที่เป็นเป้าหมายหดเกร็ง |
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] | เซลล์ประสาทสั่งการ
ในสัตว์ไม่มีกระดูกสันหลัง ใยกล้ามเนื้ออาจตอบสนองแบบเร้า (excitatory) หรือแบบยับยั้ง (inhibitory) ขึ้นอยู่กับสารสื่อประสาทที่ปล่อยและหน่วยรับที่ได้รับ
แต่ในสัตว์มีกระดูกสันหลัง ใยกล้ามเนื้อจะตอบสนองต่อสารสื่อประสาทในแบบเร้า คือโดยหดเกร็งเท่านั้น
การคลายกล้ามเนื้อ คือการระงับการหดเกร็งจะเกิดได้ก็ต่อเมื่อยับยั้งเซลล์ประสาทสั่งการเอง |
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] | เซลล์ประสาทสั่งการ
ยาคลายกล้ามเนื้อถือประโยชน์จากกลไกเช่นนี้ คือออกฤทธิ์ที่เซลล์ประสาทสั่งการซึ่งส่งกระแสประสาทไปยังกล้ามเนื้อโดยลดการทำงานทางสรีรวิทยาไฟฟ้าของมัน หรือออกฤทธิ์ที่แผ่นเชื่อมประสาทสั่งการและกล้ามเนื้อโดยขัดการทำงานของ acetylcholine และไม่ได้ออกฤทธิ์ที่กล้ามเนื้อโดยตรง |
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] | เซลล์ประสาทสั่งการ
เซลล์ประสาทสั่งการอวัยวะภายในพิเศษ (special visceral motor neuron หรือ branchial motor neuron) มีบทบาทในการแสดงออกสีหน้า การเคี้ยว การออกเสียง/การพูด และการกลืน
ประสาทสมองที่เกี่ยวข้องกันรวมทั้งเส้นประสาทกล้ามเนื้อตา (oculomotor, คู่ที่ 3), เส้นประสาทแอบดูเซนส์ (abducens, คู่ที่ 6), เส้นประสาททรอเคลียร์ (trochlear, คู่ที่ 4) และเส้นประสาทกล้ามเนื้อลิ้น (hypoglossal, คู่ที่ 12) |
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] | เซลล์ประสาทสั่งการ
เซลล์ประสาทสั่งการเหล่านี้ส่งกระแสประสาทโดยอ้อมไปยังกล้ามเนื้อหัวใจและกล้ามเนื้อเรียบของอวัยวะภายใน/กล้ามเนื้อของหลอดเลือด
มีไซแนปส์กับเซลล์ประสาทสั่งการในปมประสาทของระบบประสาทอิสระ (ไม่ว่าจะเป็นระบบซิมพาเทติกหรือพาราซิมพาเทติก) ในระบบประสาทนอกส่วนกลาง (PNS) ซึ่งก็ส่งกระแสประสาทโดยตรงไปยังกล้ามเนื้ออวัยวะภายในและเซลล์ต่อมบางอย่าง |
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] | เซลล์ประสาทสั่งการ
เพราะเหตุนี้
การสั่งการกล้ามเนื้อโครงร่างและกล้ามเนื้อ branchial จึงมีไซแนปส์เดียว (monosynaptic) คือมีเซลล์ประสาทสั่งการไม่ว่าจะเป็นส่วนร่างกายหรือส่วน branchial เดียวซึ่งมีไซแนปส์เชื่อมกับกล้ามเนื้อโดยตรง
ส่วนการสั่งการกล้ามเนื้ออวัยวะภายใน (visceral muscle) จะอาศัยไซแนปส์สองไซแนปส์ คืออาศัย เซลล์ประสาท 2 ตัว เซลล์ประสาทสั่งการอวัยวะภายในทั่วไปอยู่ในระบบประสาทกลาง (CNS) ซึ่งมีไซแนปส์ต่อกับเซลล์ประสาทในปมประสาทซึ่งอยู่ในระบบประสาทส่วนปลาย (PNS) ซึ่งก็มีไซแนปส์เชื่อมกับกล้ามเนื้อ |
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] | เซลล์ประสาทสั่งการ
เซลล์ประสาทสั่งการของสัตว์มีกระดูกสันหลังเป็นแบบ cholinergic คือมี ACh เป็นสารสื่อประสาท
เซลล์ประสาทในปมประสาทของระบบพาราซิมพาเทติกก็เป็นแบบ cholinergic ด้วย ในขณะที่เซลล์ในปมประสาทของระบบซิมพาเทติกเป็นแบบ noradrenergic คือมี norepinephrine/noradrenaline เป็นสารสื่อประสาท |
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] | เซลล์ประสาทสั่งการ
เซลล์ประสาทสั่งการล่างของมนุษย์สามารถสร้างขึ้นนอกกาย (in vitro) จากเซลล์ต้นกำเนิด คือ embryonic stem cell และ induced pluripotent stem cell |
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] | เนื้อแปรรูป
เนื้อแปรรูป () หมายถึงเนื้อสัตว์ที่ปรุงแต่งเพื่อเพิ่มรสชาติหรือเพิ่มอายุคุณภาพสินค้า
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สำนักงานวิจัยมะเร็งนานาชาติ () และองค์การอนามัยโลกจัดเนื้อแปรรูปอยู่ในสารก่อมะเร็งกลุ่มที่ 1 ในมนุษย์ เพราะพบหลักฐานเพียงพอว่า การบริโภคเนื้อแปรรูปก่อมะเร็งลำไส้ใหญ่ |
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] | เนื้อแปรรูป
รายงานปี 2016 ของสถาบันวิจัยมะเร็งอเมริกัน () และกองทุนวิจัยมะเร็งแห่งโลก () ระบุว่า การบริโภคเนื้อแปรรูปเพิ่มความเสี่ยงมะเร็งกระเพาะอาหาร
งานวิจัยปี 2012 ระบุแบคทีเรีย "Helicobacter pylori" ว่าอาจเป็นเหตุโดยแนะนำว่าควรศึกษาให้ละเอียดขึ้น |
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การแปรรูปเริ่มตั้งแต่สมัยที่มนุษย์เริ่มรู้ว่า การหุงต้มและการใส่เกลือทำให้เนื้อเสียช้าลง
แม้จะไม่รู้ว่าเริ่มขึ้นแรกสุดเมื่อไร แต่การใส่เกลือแล้วตากแดดให้แห้งมีตั้งแต่ในสมัยอียิปต์โบราณ การใช้น้ำแข็งและหิมะเริ่มในยุคโรมันต้น ๆ และคนทำขนมหวานชาวฝรั่งเศส Nicolas Appert ประดิษฐ์การบรรจุเนื้อกระป๋องในปี 1810 ซึ่งเขาได้รับรางวัลจากรัฐบาลฝรั่งเศส |
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] | เนื้อแปรรูป
สารกันเสียโซเดียมไนไตรต์ (E250) ซึ่งผสมใส่ในเกลือแปรรูป ช่วยระงับการเติบโตของสปอร์แบคทีเรีย "Clostridium botulinum" (ซึ่งสร้างชีวพิษโบทูลินัม) ในเนื้อแปรรูปและในเนื้อแช่เย็น
ปัญหาหลักของโซเดียมไนไตรต์ก็คือเมื่อเนื้อไหม้หรือสุกเกิน จะเกิดไนโตรซามีน (nitrosamine) ซึ่งก่อมะเร็ง
ไนโตรซามีนยังเกิดจากปฏิกิริยาของไนไตรต์กับอะมีน (Amine) ในสภาพกรด (เช่นที่พบในกระเพาะอาหารมนุษย์) และในกระบวนการบ่มเนื้อให้อยู่ได้นาน
ไนเตรตและไนไตรต์ที่บริโภคมาจากอาหารทั้งพืชและสัตว์ คนทั่วไป 80% จะได้ไนเตรตจากผักโดยเฉพาะที่เป็นใบหรือราก/หัว เช่น ผักโขม
ร่างกายมนุษย์จะเปลี่ยนไนเตรตเป็นไนไตรต์บางส่วน
องค์การอาหารและยาสหรัฐ () พิจารณาไนไตรต์โดยทั่วไปว่า ปลอดภัย |
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] | ขากรรไกร
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] | ขากรรไกร
ในสัตว์ขาปล้อง ขากรรไกรทำมาจากไคทินและประกบกันทางด้านข้าง ซึ่งอาจเรียกเป็นภาษาอังกฤษว่า mandibles สำหรับสัตว์เคลด Mandibulata หรือ chelicerae สำหรับสัตว์ไฟลัมย่อย เชลิเซอราตา
มักจะมีส่วนต่าง ๆ ที่เรียกว่า mouthpart (ส่วนของปาก)
มีหน้าที่หลักเพื่อหาอาหาร ส่งอาหารไปที่ปาก และ/หรือเคี้ยวอาหาร
ส่วนของปากและโครงสร้างที่เกี่ยวกัน (เช่น pedipalp) หลายส่วน ได้วิวัฒนาการมาจากขา |
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ในสัตว์มีกระดูกสันหลังโดยมาก ขากรรไกจะเป็นกระดูกหรือกระดูกอ่อน ประกบกันทางด้านบน-ล่าง จึงมีขากรรไกรบนและล่าง
พัฒนาการ/วิวัฒนาการมาจากส่วนโค้งคอหอย (pharyngeal arch) หน้าสุดสองชุดซึ่งค้ำเหงือก ปกติมีฟันหลายซี่ |
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] | ขากรรไกร
ขากรรไกของสัตว์มีกระดูกสันหลังน่าจะวิวัฒนาการขึ้นในยุคไซลูเรียน ซึ่งปรากฏในปลามีเกราะ แล้วหลายหลากยิ่งขึ้นในยุคดีโวเนียน
ส่วนโค้งคอหอยหน้าสุดสองชุดเชื่อว่าได้กลายเป็นขากรรไกรและส่วนโค้งกระดูกไฮออยด์ (hyoid arch) ตามลำดับ
ระบบกระดูกไฮออยด์แขวนขากรรไกรไว้กับกระดูกหุ้มสมอง ทำให้ขยับขากรรไกรได้อย่างสะดวก
แม้จะไม่มีหลักฐานซากดึกดำบรรพ์ที่สนับสนุนทฤษฎีนี้ แต่ก็เข้ากับสิ่งที่เห็นว่า สัตว์มีกระดูกสันหลังที่มีขากรรไกร (อินฟราไฟลัม Gnathostomata) มีส่วนโค้งคอหอยเพียงแค่ 7 ชุด แต่สัตว์มีกระดูกสันหลังที่ไร้ขากรรไกร (ปลาไม่มีขากรรไกร) มี 9 ชุด |
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] | ขากรรไกร
ประโยชน์ของขากรรไกรที่ได้คัดเลือกในเบื้องต้นอาจไม่เกี่ยวกับการกิน แต่ทำให้หายใจอย่างมีประสิทธิภาพยิ่งขึ้น
คือใช้เป็นปัมพ์ (buccal pump ดังที่เห็นในปลาและสัตว์สะเทินน้ำสะเทินบกปัจจุบัน) ส่งน้ำไปที่เหงือก (ปลา) หรือส่งอากาศไปที่ปอด (สัตว์สะเทินน้ำสะเทินบก)
แล้วในที่สุดก็วิวัฒนาการมาเป็นขากรรไกรดังที่เห็นในมนุษย์เพื่อใช้กินอาหาร ซึ่งเป็นหน้าที่สำคัญมากในสัตว์มีกระดูกสันหลัง
ส่วนปลา teleost (infraclass Teleostei) หลายชนิดมีขากรรไกรที่วิวัฒนาการเพื่อดูดกิน และเพื่อยื่นขากรรไกรออก จึงเป็นโครงสร้างที่ซับซ้อนมากและมีกระดูกที่เกี่ยวข้องเป็นโหล ๆ |
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] | ขากรรไกร
ขากรรไกของ tetrapod (superclass Tetrapoda) ง่ายกว่าของปลามาก
เพราะกระดูกขากรรไกส่วนบนต่าง ๆ (คือ premaxilla, maxilla, jugal, quadratojugal และ quadrate) ได้เชื่อมยึดกับกระดูกหุ้มสมอง และกระดูกขากรรไกรล่างต่าง ๆ (dentary, splenial, angular, surangular และ articular) ได้เชื่อมเป็นหน่วยเดียวกันโดยเรียกว่า ขากรรไกรล่าง (mandible)
ขากรรไกรทั้งสองเชื่อมเป็นข้อที่กระดูก quadrate กับ articular
และสามารถขยับกระดูกต่าง ๆ มากน้อยต่างกันแล้วแต่สัตว์
สัตว์บางสปีชีส์มีกระดูกขากรรไกรที่เชื่อมเข้าด้วยกันโดยสิ้นเชิง บางสปีชีส์มีข้อต่อให้เคลื่อนกระดูก dentary, quadrate หรือ maxilla ได้
ส่วนงูสามารถขยับขากรรไกรได้มากที่สุด ทำให้สามารถกลืนเหยื่อขนาดใหญ่ได้ |
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] | ขากรรไกร
สัตว์เลี้ยงลูกด้วยนมมีขากรรไกรล่าง (mandible) และขากรรไกรบน (maxilla)
ส่วนเอปมีโครงสร้างทำให้ขากรรไกรล่างแข็งแรงขึ้นที่เรียกว่า simian shelf ซึ่งมนุษย์ปัจจุบันไม่มี
ในวิวัฒนาการของขากรรไกรสัตว์เลี้ยงลูกด้วยนม กระดูกสองชิ้น (คือ articular ของขากรรไกรล่าง และ quadrate ของขากรรไกรบน) ได้ลดขนาดลงแล้วรวมเข้าเป็นส่วนของหู และมีกระดูกอีกจำนวนหนึ่งที่เชื่อมเข้าด้วยกัน
ดังนั้น จึงขยับกระดูกต่าง ๆ ได้ไม่ดี และขากรรไกรล่างจึงเชื่อมกับกระดูกขมับด้วยข้อต่อขากรรไกร (temporomandibular joint)
มีโรคสามัญที่ข้อต่อนี้เรียกว่า temporomandibular joint dysfunction (การทำหน้าที่ผิดปกติของข้อต่อขากรรไกร) ซึ่งมีอาการเจ็บ ส่งเสียงเมื่อขยับ และขยับขากรรไกรล่างไม่สะดวก |
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เม่นทะเลมีขากรรไกรพิเศษซึ่งปรากฏเป็นส่วนที่สมมาตรกัน 5 ส่วน
แต่ละส่วนยึดกับฟันซี่เดียวที่งอกออกเรื่อย ๆ ทำด้วยแคลเซียมคาร์บอเนตที่เป็นผลึก |
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] | สารในกระบวนการสร้างและสลาย
เมแทบอไลต์ หรือ สารในกระบวนการสร้างและสลาย
เป็นสารมัธยันตร์ (intermediate) คือไม่ใช่สารที่ได้ในที่สุดของกระบวนการเมแทบอลิซึม
คำปกติจะจำกัดใช้กับสารที่โมเลกุลเล็ก
เมแทบอไลต์มีหน้าที่ต่าง ๆ รวมทั้งเป็นพลังงาน โครงสร้าง สัญญาณ (signaling) มีผลกระตุ้นหรือยับยั้งเอนไซม์ เป็นสารเร่งปฏิกิริยาเอง (โดยเป็นโคแฟกเตอร์ของเอนไซม์) ป้องกันสิ่งมีชีวิต และมีปฏิสัมพันธ์กับสิ่งมีชีวิตอื่น ๆ
เมแทบอไลต์ปฐมภูมิ () มีส่วนเกี่ยวข้องกับการเติบโต การดำรงสภาพ และการรอดชีวิตของสิ่งมีชีวิต
ตัวอย่างเช่น เอทิลีน ซึ่งสามารถผลิตในระดับอุตสาหกรรมด้วยจุลชีพ
ส่วน เมแทบอไลต์ทุติยภูมิ () ไม่เกี่ยวกับกระบวนการเช่นนั้น แต่อาจมีหน้าที่ทางนิเวศ
ตัวอย่างคือ ยาปฏิชีวนะและสารสี เช่น เรซินและ terpene
เป็นต้น
ยาปฏิชีวนะบางอย่างมีเมแทบอไลต์ปฐมภูมิเป็นสารตั้งต้น เช่น ยา actinomycin สร้างจากเมแทบอไลต์ปฐมภูมิคือ tryptophan
น้ำตาลบางอย่างเป็นเมแทบอไลต์ เช่น ฟรักโทสหรือกลูโคส ทั้งสองอยู่ในวิถีเมแทบอลิซึมของกระบวนการต่าง ๆ ในเซลล์ |
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สารเคมีมีโมเลกุลเล็กทั้งหมดในสิ่งมีชีวิตมีปฏิกิริยาทางเมทาบอลิซึมมากมาย โดยผลผลิตที่ได้จากปฏิกิริยาที่เร่งด้วยเอนไซม์หนึ่ง ๆ จะใช้เป็นสารตั้งต้นของปฏิกิริยาอีกอย่างหนึ่ง
เมทาบอไลต์จากสารประกอบเคมี ไม่ว่าที่มีตามธรรมชาติหรือที่ทำเพื่อเป็นยา เกิดจากกระบวนการเคมีชีวภาพที่สลายและกำจัดสารประกอบ
อัตราการแตกสารประกอบเป็นตัวกำหนดระยะและความแรงของปฏิกิริยา
การกำหนดเมแทบอไลต์ของสารประกอบที่ใช้เป็นยา คือเมแทบอลิซึมของยา เป็นส่วนสำคัญในการค้นพบยา เพราะทำให้สามารถเข้าใจผลข้างเคียงที่ไม่ต้องการ |
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] | เขตเกรเวินมัคเคอร์
เขตเกรเวินมัคเคอร์ (; ; ) เป็นเขตการปกครองเขตหนึ่งในอดีตของประเทศลักเซมเบิร์ก ประกอบด้วย 3 อำเภอ และ 26 เทศบาล |
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] | รักพลิกล็อก
รักพลิกล็อก () เป็นละครโทรทัศน์ไทย แนว โรแมนติก-ดราม่า-คอมเมดี้ นำแสดงโดย คณิน ชอบประดิถ,ปีเตอร์ เดนแมน, สุชาร์ มานะยิ่ง และ มณีรัตน์ ศรีจรูญ ผลิตโดย บริษัท นอร์ธสตาร์ โปรดักชั่น จำกัด ดัดแปลงจากบทประพันธ์ของ เทพิตา กำกับการแสดงโดย สรัสวดี วงศ์สมเพ็ชร ออกอากาศทุกวันศุกร์ เวลา 20.00 - 20.15 น. และรับชมต่อเนื่องในเวลา 20.45 - 23.00 น. และวันเสาร์ถึงวันอาทิตย์ เวลา 20.15 - 22.45 น. ทาง ช่อง 33 เริ่มตอนแรกวันศุกร์ที่ 23 พฤศจิกายน 2561 |
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] | ไผ่เลี้ยง
ไผ่เลี้ยง ("Bambusa multiplex") เป็นสายพันธุ์ของไผ่ มีถิ่นกำเนิดในจีน (จังหวัด Guangdong, Guangxi, Hainan, Hunan, Jiangxi, Sichuan, Yunnan) เนปาล, ภูฏาน, รัฐอัสสัม, ศรีลังกา, ไต้หวัน, และส่วนเหนือของอินโดจีน นอกจากนี้ยังพบได้ในอิรัก, มาดากัสการ์, มอริเชียส, เซเชลส์, อนุทวีปอินเดีย, บางส่วนของอเมริกาใต้, เวสต์อินดีส, และทางตะวันออกเฉียงใต้ของสหรัฐอเมริกา (ฟลอริดา, จอร์เจีย, แอละแบมา)
มีความสูง 2-3 เมตร มีลำต้นสูง เส้นผ่าศูนย์กลาง 2-6 เซนติเมตร พุ่มกว้าง 4-6 เมตร ลำกลมและเกลี้ยง สีเขียวเป็นมันและมีขนสีขาวนวลอยู่ตามข้อ และใบเป็นลักษณะแคบเล็ก ปลายแหลม ขอบใบเรียบ ใบแตกออกบริเวณกลางลำ ทำให้ดูเป็นพุ่มอยู่ส่วนยอดของต้น มีใบดกมาก
สามารถขยายพันธุ์ด้วยการแยกกอ |
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เกรเวินมัคเคอร์ (; ) เป็นอำเภอของประเทศลักเซมเบิร์ก เมืองหลักของอำเภอนี้ก็ชื่อว่าเกรเวินมัคเคอร์ |
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