mihirhirave/entity_extraction_ade_v2_with_validation

text stringlengths 22 455	relations listlengths 1 24
Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.	[ { "ade": "manic episodes", "drug": "alprazolam" } ]
Simvastatin-induced rhabdomyolysis following cyclosporine treatment for uveitis.	[ { "ade": "rhabdomyolysis", "drug": "cyclosporine" }, { "ade": "rhabdomyolysis", "drug": "Simvastatin" } ]
OBJECTIVE: To report a case of angioedema associated with losartan administration.	[ { "ade": "angioedema", "drug": "losartan" } ]
Eosinophilic cystitis after bladder instillation with dimethyl sulfoxide.	[ { "ade": "Eosinophilic cystitis", "drug": "dimethyl sulfoxide" } ]
These findings suggest that clozapine-induced seizures can be successfully treated, that gradual dose titration can reduce the likelihood of further episodes of seizures and that concomitant use of a suitable mood stabilizer/anti-epileptic medication can improve the outcome of treatment-resistant schizophrenia.	[ { "ade": "seizures", "drug": "clozapine" } ]
A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.	[ { "ade": "toxic encephalopathy", "drug": "pyrilamine maleate" }, { "ade": "depressed level of consciousness", "drug": "pyrilamine maleate" }, { "ade": "ataxia", "drug": "pyrilamine maleate" }, { "ade": "marked irritability", "drug": "pyrilamine maleate" }, { "ade": "toxic encephalopathy", "drug": "pentobarbital" }, { "ade": "ataxia", "drug": "pentobarbital" }, { "ade": "depressed level of consciousness", "drug": "pentobarbital" }, { "ade": "marked irritability", "drug": "pentobarbital" } ]
After three weeks of carbamazepine therapy, the patient arrived at the emergency department (ED) with severe agitation and aggressive behavior.	[ { "ade": "aggressive behavior", "drug": "carbamazepine" }, { "ade": "severe agitation", "drug": "carbamazepine" } ]
We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).	[ { "ade": "meningitis", "drug": "TMP" }, { "ade": "meningitis", "drug": "trimethoprim" }, { "ade": "meningitis", "drug": "SMX" }, { "ade": "meningitis", "drug": "sulfamethoxazole" } ]
Here, we report a case of angio-oedema associated with VRC therapy.	[ { "ade": "angio-oedema", "drug": "VRC" } ]
Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: "the retinoic acid syndrome".	[ { "ade": "retinoic acid syndrome", "drug": "retinoic acid" }, { "ade": "fatal complication", "drug": "retinoic acid" } ]
The epivodes of NMS occured under treatment with clozapine, risperidone, and amisulpride.	[ { "ade": "NMS", "drug": "amisulpride" }, { "ade": "NMS", "drug": "risperidone" }, { "ade": "NMS", "drug": "clozapine" } ]
Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.	[ { "ade": "hematologic malignancy", "drug": "doxorubicin" }, { "ade": "hematologic malignancy", "drug": "etoglucid" }, { "ade": "hematologic malignancy", "drug": "mitomycin C" } ]
The case concerns the sudden death of a 29-year-old male during clozapine therapy started 2 weeks before.	[ { "ade": "sudden death", "drug": "clozapine" } ]
Aripiprazole-induced hiccups: a case report.	[ { "ade": "hiccups", "drug": "Aripiprazole" } ]
CASE SUMMARY: A 10-year-old white girl with bilateral optic glioma developed a hypersensitivity reaction to carboplatin after nine courses.	[ { "ade": "hypersensitivity", "drug": "carboplatin" } ]
Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.	[ { "ade": "Cholesterol crystal embolization", "drug": "tissue-type plasminogen activator" }, { "ade": "renal failure", "drug": "tissue-type plasminogen activator" } ]
Nonoliguric acute renal failure after captopril therapy.	[ { "ade": "Nonoliguric acute renal failure", "drug": "captopril" } ]
Acute hyperphosphatemia caused by sodium phosphate enema in a patient with liver dysfunction and chronic renal failure.	[ { "ade": "hyperphosphatemia", "drug": "sodium phosphate" } ]
Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.	[ { "ade": "purple discoloration", "drug": "phenytoin" }, { "ade": "swelling of the hands", "drug": "phenytoin" }, { "ade": "Purple glove syndrome", "drug": "phenytoin" } ]
Anaphylactoid reactions with intraperitoneal cisplatin.	[ { "ade": "Anaphylactoid reactions", "drug": "cisplatin" } ]
The frequency and relationship of granulocytopenia caused by sustained-release procainamide in patients with tachyarrhythmias are briefly discussed, and prior reported cases are reviewed.	[ { "ade": "granulocytopenia", "drug": "procainamide" } ]
Acute ocular ischemic change may be associated with intravitreal injection of bevacizumab in patients with vascular compromised diabetic retinopathy and/or underlying stenosis of the carotid artery.	[ { "ade": "Acute ocular ischemic change", "drug": "bevacizumab" } ]
Toxicity related to chloroquine treatment of resistant vivax malaria.	[ { "ade": "Toxicity", "drug": "chloroquine" } ]
Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects.	[ { "ade": "birth defects", "drug": "Zidovudine" } ]
Progressive interstitial lung disease from prolonged methotrexate therapy.	[ { "ade": "Progressive interstitial lung disease", "drug": "methotrexate" } ]
The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.	[ { "ade": "TEN", "drug": "TMP-Sx" }, { "ade": "SJS", "drug": "TMP-Sx" } ]
Spinal cord infarction during use of zolmitriptan: a case report.	[ { "ade": "Spinal cord infarction", "drug": "zolmitriptan" } ]
We evaluated a patient who developed a psychotic disorder after 4 months of isoniazid prophylaxis for a positive tuberculosis tine test.	[ { "ade": "psychotic disorder", "drug": "isoniazid" } ]
CASES: "A" was an 8-year-old boy with attention deficit and chronic tic disorder who developed obsessive-compulsive symptoms within 2 weeks of starting risperidone.	[ { "ade": "obsessive-compulsive symptoms", "drug": "risperidone" } ]
The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.	[ { "ade": "cholestasis", "drug": "thiabendazole" }, { "ade": "sicca complex", "drug": "thiabendazole" } ]
Primary central nervous system lymphoma in a patient treated with natalizumab.	[ { "ade": "Primary central nervous system lymphoma", "drug": "natalizumab" } ]
We report a case of vitiligo that occurred during the second month of interferon alpha 2a therapy for chronic active hepatitis C.	[ { "ade": "vitiligo", "drug": "interferon alpha 2a" } ]
Prolonged used of hydroxyurea in patients with ET may lead to therapy-associated acute leukemia.	[ { "ade": "acute leukemia", "drug": "hydroxyurea" } ]
Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.	[ { "ade": "fibrotic lesions", "drug": "cyclophosphamide" }, { "ade": "fibrotic lesions", "drug": "bleomycin" } ]
The cough continued for the duration of therapy with quinapril.	[ { "ade": "cough", "drug": "quinapril" } ]
Acne provoked by gold seems not to have been described elsewhere.	[ { "ade": "Acne", "drug": "gold" } ]
A 17-year-old boy with acute lymphoblastic leukemia developed acute renal failure within 48 h of an intravenous high-dose methotrexate (5 g/m2) infusion.	[ { "ade": "acute renal failure", "drug": "methotrexate" } ]
Nevertheless, the coagulopathy seemed to be most closely associated with the administration of the cephalosporin.	[ { "ade": "coagulopathy", "drug": "cephalosporin" } ]
Intravenous sodium bicarbonate appears to be indicated prophylactically in combating the associated metabolic acidosis due to absorbed formic acid.	[ { "ade": "metabolic acidosis", "drug": "formic acid" } ]
We describe a life threatening side effect of acute epoprostenol infusion (pulmonary edema) in a patient with pulmonary hypertension associated with limited scleroderma and discuss its management and potential etiology.	[ { "ade": "pulmonary edema", "drug": "epoprostenol" } ]
CONCLUSIONS: Anastrozole may be the causative factor in patients with sclerosing glomerulonephritis.	[ { "ade": "sclerosing glomerulonephritis", "drug": "Anastrozole" } ]
She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.	[ { "ade": "dizziness", "drug": "capecitabine" }, { "ade": "sore throat", "drug": "capecitabine" }, { "ade": "generalized rash", "drug": "capecitabine" }, { "ade": "itching", "drug": "capecitabine" } ]
Risperidone withdrawal-related respiratory dyskinesia: a case diagnosed by spirography and fibroscopy.	[ { "ade": "respiratory dyskinesia", "drug": "Risperidone" } ]
Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion.	[ { "ade": "Myoglobinuria", "drug": "vasopressin" }, { "ade": "acute renal failure", "drug": "vasopressin" } ]
A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator.	[ { "ade": "behavioral change", "drug": "cinepazide" } ]
Although they had complex medical problems, the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy.	[ { "ade": "seizures", "drug": "ampicillin" } ]
Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.	[ { "ade": "Uveitis", "drug": "rifabutin" }, { "ade": "Uveitis", "drug": "ethambutol" }, { "ade": "Uveitis", "drug": "clarithromycin" } ]
METHODS: A patient who developed dramatic, permanent vision loss after a 9-month course of treatment with ethambutol and isoniazid for pulmonary tuberculosis is presented.	[ { "ade": "vision loss", "drug": "isoniazid" }, { "ade": "vision loss", "drug": "ethambutol" } ]
Toxic optic neuropathy associated with ethambutol: implications for current therapy.	[ { "ade": "Toxic optic neuropathy", "drug": "ethambutol" } ]
The case of an adult who developed both hepatic dysfunction and an impaired macrophage migration after exposure to cimetidine is discussed.	[ { "ade": "hepatic dysfunction", "drug": "cimetidine" }, { "ade": "impaired macrophage migration", "drug": "cimetidine" } ]
We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy.	[ { "ade": "leukopenia", "drug": "AZA" } ]
We report such a series of patients who had transient asymptomatic bradycardia after being treated with continuous infusion 5-FU.	[ { "ade": "transient asymptomatic bradycardia", "drug": "5-FU" } ]
Embolia cutis medicamentosa following subcutaneous injection of glatiramer acetate.	[ { "ade": "Embolia cutis medicamentosa", "drug": "glatiramer acetate" } ]
Reports of colonic perforation as a result of the administration of calcium polystyrene sulfonate and sorbitol are rare.	[ { "ade": "colonic perforation", "drug": "sorbitol" }, { "ade": "colonic perforation", "drug": "calcium polystyrene sulfonate" } ]
Sorafenib induced tumor lysis syndrome in an advanced hepatocellular carcinoma patient.	[ { "ade": "tumor lysis syndrome", "drug": "Sorafenib" } ]
The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.	[ { "ade": "erythema multiforme", "drug": "sulfonamides" }, { "ade": "Stevens-Johnson syndrome", "drug": "sulfonamides" } ]
Lansoprazole-induced thrombocytopenia.	[ { "ade": "thrombocytopenia", "drug": "Lansoprazole" } ]
We report a case of hyperpigmentation due to bleomycin treatment in a patient with acquired immune deficiency syndrome (AIDS).	[ { "ade": "hyperpigmentation", "drug": "bleomycin" } ]
Carbamazepine-induced tics.	[ { "ade": "tics", "drug": "Carbamazepine" } ]
Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.	[ { "ade": "Iatrogenic Cushing syndrome", "drug": "triamcinolone" } ]
Captopril is known to be associated with dermatologic, hematologic, and pulmonary adverse effects.	[ { "ade": "dermatologic, hematologic, and pulmonary adverse effects", "drug": "Captopril" } ]
Nonconvulsive status epilepticus: the role of morphine and its antagonist.	[ { "ade": "Nonconvulsive status epilepticus", "drug": "morphine" } ]
PURPOSE: To describe the clinical and electrophysiological findings in a young boy with decreased vision possibly due to retinal damage by rifabutin.	[ { "ade": "decreased vision", "drug": "rifabutin" }, { "ade": "retinal damage", "drug": "rifabutin" } ]
Furosemide-associated fever.	[ { "ade": "fever", "drug": "Furosemide" } ]
We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.	[ { "ade": "ARDS", "drug": "pegylated interferon alpha-2a" }, { "ade": "ARDS", "drug": "pegIFNalpha-2a" }, { "ade": "ARDS", "drug": "ribavirin" }, { "ade": "adult respiratory distress syndrome", "drug": "ribavirin" }, { "ade": "adult respiratory distress syndrome", "drug": "pegylated interferon alpha-2a" }, { "ade": "adult respiratory distress syndrome", "drug": "pegIFNalpha-2a" } ]
This case report describes a 38-year-old male in whom SIADH was strongly suspected secondary to Tegretol therapy to control a seizure disorder.	[ { "ade": "SIADH", "drug": "Tegretol" } ]
In one case, disulfiram was the only potential teratogen exposed to the fetus.	[ { "ade": "teratogen", "drug": "disulfiram" } ]
A patient developed optic neuropathy while being treated with isoniazid and ethambutol.	[ { "ade": "optic neuropathy", "drug": "isoniazid" }, { "ade": "optic neuropathy", "drug": "ethambutol" } ]
Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication.	[ { "ade": "psychotic decompensations", "drug": "amantadine" } ]
We observed 2 cases of hepatotoxicity after a high-dose methylprednisolone treatment of a demyelinating disease and evaluated the potential relationship in the light of available evidence.	[ { "ade": "hepatotoxicity", "drug": "methylprednisolone" } ]
Experience with five patients in whom impaired renal function developed early during amphotericin B therapy is reported.	[ { "ade": "impaired renal function", "drug": "amphotericin B" } ]
Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature.	[ { "ade": "acute amnestic episode", "drug": "clioquinol" } ]
We describe a 73-year-old woman who developed serious systemic vasculitis with associated thrombocytopenia in the course of treatment with cladribine.	[ { "ade": "systemic vasculitis", "drug": "cladribine" }, { "ade": "thrombocytopenia", "drug": "cladribine" } ]
Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.	[ { "ade": "progressive visual loss", "drug": "MTX" }, { "ade": "death", "drug": "MTX" }, { "ade": "death", "drug": "Ara-C" }, { "ade": "loss of consciousness", "drug": "Ara-C" }, { "ade": "loss of consciousness", "drug": "MTX" }, { "ade": "progressive visual loss", "drug": "Ara-C" } ]
Ezetimibe-induced acute pancreatitis.	[ { "ade": "acute pancreatitis", "drug": "Ezetimibe" } ]
This is the first case of HBV reactivation occurring during the year following rituximab monotherapy in the absence of any other immunosuppressive factor.	[ { "ade": "HBV reactivation", "drug": "rituximab" } ]
Fatal outcome of intravesical formalin instillation, with changes mimicking renal tuberculosis.	[ { "ade": "Fatal outcome", "drug": "formalin" } ]
We report a case of a women in whom a malignant mixed mesodermal tumor was diagnosed while she was taking raloxifene, which is also a selective estrogen receptor modulator.	[ { "ade": "malignant mixed mesodermal tumor", "drug": "raloxifene" } ]
The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia.	[ { "ade": "pericardial hemorrhage", "drug": "acetylsalicylic acid" } ]
In two of these cases akathisia resolved after withdrawal of olanzapine and substitution by a classical or an atypical neuroleptic agent, respectively.	[ { "ade": "akathisia", "drug": "olanzapine" } ]
Interstitial pneumonia probably associated with sorafenib treatment: An alert of an adverse event.	[ { "ade": "Interstitial pneumonia", "drug": "sorafenib" } ]
This report describes a probable case of infliximab-induced membranous nephropathy.	[ { "ade": "membranous nephropathy", "drug": "infliximab" } ]
The first patient developed a monoarthritis 2 weeks after initiation of IFN-beta, which persisted during the 14 months of therapy and resolved with discontinuation of the medication.	[ { "ade": "monoarthritis", "drug": "IFN-beta" } ]
Late development of diabetes mellitus after interferon-alfa and ribavirin therapy for chronic hepatitis C: a case report.	[ { "ade": "diabetes mellitus", "drug": "ribavirin" }, { "ade": "diabetes mellitus", "drug": "interferon-alfa" } ]
We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-elonic seizures.	[ { "ade": "antidiuresis", "drug": "carbamazepine" } ]
This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.	[ { "ade": "multiple nodules in the liver", "drug": "phosphate diethylstilbestrol" }, { "ade": "multiple nodules in the liver", "drug": "PDES" } ]
Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases.	[ { "ade": "Cutaneous sarcoidosis", "drug": "ribavirin" }, { "ade": "Cutaneous sarcoidosis", "drug": "interferon alfa" } ]
Acceleration of ventricular response to atrial flutter after intravenous adenosine.	[ { "ade": "Acceleration of ventricular response", "drug": "adenosine" } ]
The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.	[ { "ade": "skin cancers", "drug": "hydroxyurea" }, { "ade": "painful hand ulcer", "drug": "hydroxyurea" } ]
Other upper tract neoplasms after cyclophosphamide are reviewed.	[ { "ade": "upper tract neoplasms", "drug": "cyclophosphamide" } ]
Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.	[ { "ade": "severe persistent bronchospasm", "drug": "tobramycin" }, { "ade": "recurrent eosinophilia", "drug": "tobramycin" } ]
On the 3rd day, an inferior vena cava (IVC) filter was placed with a heparin flush, after which massive IVC thrombosis developed.	[ { "ade": "IVC thrombosis", "drug": "heparin" } ]
Zoledronic acid-induced severe hypocalcaemia in a prostate cancer patient with extensive osteoblastic bone metastases.	[ { "ade": "severe hypocalcaemia", "drug": "Zoledronic acid" } ]
CONCLUSIONS: Amphotericin B overdose can be fatal in children and infants.	[ { "ade": "fatal", "drug": "Amphotericin B" } ]
While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.	[ { "ade": "ocular effects", "drug": "digoxin" }, { "ade": "visual changes", "drug": "digoxin" }, { "ade": "ocular effects", "drug": "amiodarone" }, { "ade": "visual changes", "drug": "amiodarone" } ]
Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system.	[ { "ade": "neurologic symptoms", "drug": "Acyclovir" } ]
Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.	[ { "ade": "coagulopathy", "drug": "cephalosporin" }, { "ade": "coagulopathy", "drug": "moxalactam" } ]
CONCLUSIONS: We report the first case of gemcitabine-induced LABD.	[ { "ade": "LABD", "drug": "gemcitabine" } ]
Early recognition of hereditary motor and sensory neuropathy type 1 can avoid life-threatening vincristine neurotoxicity.	[ { "ade": "life-threatening vincristine neurotoxicity", "drug": "vincristine" } ]
By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.	[ { "ade": "platelet activation", "drug": "heparin" }, { "ade": "platelet activation", "drug": "Clexane" }, { "ade": "platelet activation", "drug": "Fraxiparin" }, { "ade": "platelet activation", "drug": "Fragmin" } ]

Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.

[ { "ade": "manic episodes", "drug": "alprazolam" } ]

Simvastatin-induced rhabdomyolysis following cyclosporine treatment for uveitis.

[ { "ade": "rhabdomyolysis", "drug": "cyclosporine" }, { "ade": "rhabdomyolysis", "drug": "Simvastatin" } ]

OBJECTIVE: To report a case of angioedema associated with losartan administration.

[ { "ade": "angioedema", "drug": "losartan" } ]

Eosinophilic cystitis after bladder instillation with dimethyl sulfoxide.

[ { "ade": "Eosinophilic cystitis", "drug": "dimethyl sulfoxide" } ]

These findings suggest that clozapine-induced seizures can be successfully treated, that gradual dose titration can reduce the likelihood of further episodes of seizures and that concomitant use of a suitable mood stabilizer/anti-epileptic medication can improve the outcome of treatment-resistant schizophrenia.

[ { "ade": "seizures", "drug": "clozapine" } ]

A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.

[ { "ade": "toxic encephalopathy", "drug": "pyrilamine maleate" }, { "ade": "depressed level of consciousness", "drug": "pyrilamine maleate" }, { "ade": "ataxia", "drug": "pyrilamine maleate" }, { "ade": "marked irritability", "drug": "pyrilamine maleate" }, { "ade": "toxic encephalopathy", "drug": "pentobarbital" }, { "ade": "ataxia", "drug": "pentobarbital" }, { "ade": "depressed level of consciousness", "drug": "pentobarbital" }, { "ade": "marked irritability", "drug": "pentobarbital" } ]

After three weeks of carbamazepine therapy, the patient arrived at the emergency department (ED) with severe agitation and aggressive behavior.

[ { "ade": "aggressive behavior", "drug": "carbamazepine" }, { "ade": "severe agitation", "drug": "carbamazepine" } ]

We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).

[ { "ade": "meningitis", "drug": "TMP" }, { "ade": "meningitis", "drug": "trimethoprim" }, { "ade": "meningitis", "drug": "SMX" }, { "ade": "meningitis", "drug": "sulfamethoxazole" } ]

Here, we report a case of angio-oedema associated with VRC therapy.

[ { "ade": "angio-oedema", "drug": "VRC" } ]

Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: "the retinoic acid syndrome".

[ { "ade": "retinoic acid syndrome", "drug": "retinoic acid" }, { "ade": "fatal complication", "drug": "retinoic acid" } ]

The epivodes of NMS occured under treatment with clozapine, risperidone, and amisulpride.

[ { "ade": "NMS", "drug": "amisulpride" }, { "ade": "NMS", "drug": "risperidone" }, { "ade": "NMS", "drug": "clozapine" } ]

Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.

[ { "ade": "hematologic malignancy", "drug": "doxorubicin" }, { "ade": "hematologic malignancy", "drug": "etoglucid" }, { "ade": "hematologic malignancy", "drug": "mitomycin C" } ]

The case concerns the sudden death of a 29-year-old male during clozapine therapy started 2 weeks before.

[ { "ade": "sudden death", "drug": "clozapine" } ]

Aripiprazole-induced hiccups: a case report.

[ { "ade": "hiccups", "drug": "Aripiprazole" } ]

CASE SUMMARY: A 10-year-old white girl with bilateral optic glioma developed a hypersensitivity reaction to carboplatin after nine courses.

[ { "ade": "hypersensitivity", "drug": "carboplatin" } ]

Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.

[ { "ade": "Cholesterol crystal embolization", "drug": "tissue-type plasminogen activator" }, { "ade": "renal failure", "drug": "tissue-type plasminogen activator" } ]

Nonoliguric acute renal failure after captopril therapy.

[ { "ade": "Nonoliguric acute renal failure", "drug": "captopril" } ]

Acute hyperphosphatemia caused by sodium phosphate enema in a patient with liver dysfunction and chronic renal failure.

[ { "ade": "hyperphosphatemia", "drug": "sodium phosphate" } ]

Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.

[ { "ade": "purple discoloration", "drug": "phenytoin" }, { "ade": "swelling of the hands", "drug": "phenytoin" }, { "ade": "Purple glove syndrome", "drug": "phenytoin" } ]

Anaphylactoid reactions with intraperitoneal cisplatin.

[ { "ade": "Anaphylactoid reactions", "drug": "cisplatin" } ]

The frequency and relationship of granulocytopenia caused by sustained-release procainamide in patients with tachyarrhythmias are briefly discussed, and prior reported cases are reviewed.

[ { "ade": "granulocytopenia", "drug": "procainamide" } ]

Acute ocular ischemic change may be associated with intravitreal injection of bevacizumab in patients with vascular compromised diabetic retinopathy and/or underlying stenosis of the carotid artery.

[ { "ade": "Acute ocular ischemic change", "drug": "bevacizumab" } ]

Toxicity related to chloroquine treatment of resistant vivax malaria.

[ { "ade": "Toxicity", "drug": "chloroquine" } ]

Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects.

[ { "ade": "birth defects", "drug": "Zidovudine" } ]

Progressive interstitial lung disease from prolonged methotrexate therapy.

[ { "ade": "Progressive interstitial lung disease", "drug": "methotrexate" } ]

The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.

[ { "ade": "TEN", "drug": "TMP-Sx" }, { "ade": "SJS", "drug": "TMP-Sx" } ]

Spinal cord infarction during use of zolmitriptan: a case report.

[ { "ade": "Spinal cord infarction", "drug": "zolmitriptan" } ]

We evaluated a patient who developed a psychotic disorder after 4 months of isoniazid prophylaxis for a positive tuberculosis tine test.

[ { "ade": "psychotic disorder", "drug": "isoniazid" } ]

CASES: "A" was an 8-year-old boy with attention deficit and chronic tic disorder who developed obsessive-compulsive symptoms within 2 weeks of starting risperidone.

[ { "ade": "obsessive-compulsive symptoms", "drug": "risperidone" } ]

The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.

[ { "ade": "cholestasis", "drug": "thiabendazole" }, { "ade": "sicca complex", "drug": "thiabendazole" } ]

Primary central nervous system lymphoma in a patient treated with natalizumab.

[ { "ade": "Primary central nervous system lymphoma", "drug": "natalizumab" } ]

We report a case of vitiligo that occurred during the second month of interferon alpha 2a therapy for chronic active hepatitis C.

[ { "ade": "vitiligo", "drug": "interferon alpha 2a" } ]

Prolonged used of hydroxyurea in patients with ET may lead to therapy-associated acute leukemia.

[ { "ade": "acute leukemia", "drug": "hydroxyurea" } ]

Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.

[ { "ade": "fibrotic lesions", "drug": "cyclophosphamide" }, { "ade": "fibrotic lesions", "drug": "bleomycin" } ]

The cough continued for the duration of therapy with quinapril.

[ { "ade": "cough", "drug": "quinapril" } ]

Acne provoked by gold seems not to have been described elsewhere.

[ { "ade": "Acne", "drug": "gold" } ]

A 17-year-old boy with acute lymphoblastic leukemia developed acute renal failure within 48 h of an intravenous high-dose methotrexate (5 g/m2) infusion.

[ { "ade": "acute renal failure", "drug": "methotrexate" } ]

Nevertheless, the coagulopathy seemed to be most closely associated with the administration of the cephalosporin.

[ { "ade": "coagulopathy", "drug": "cephalosporin" } ]

Intravenous sodium bicarbonate appears to be indicated prophylactically in combating the associated metabolic acidosis due to absorbed formic acid.

[ { "ade": "metabolic acidosis", "drug": "formic acid" } ]

We describe a life threatening side effect of acute epoprostenol infusion (pulmonary edema) in a patient with pulmonary hypertension associated with limited scleroderma and discuss its management and potential etiology.

[ { "ade": "pulmonary edema", "drug": "epoprostenol" } ]

CONCLUSIONS: Anastrozole may be the causative factor in patients with sclerosing glomerulonephritis.

[ { "ade": "sclerosing glomerulonephritis", "drug": "Anastrozole" } ]

She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.

[ { "ade": "dizziness", "drug": "capecitabine" }, { "ade": "sore throat", "drug": "capecitabine" }, { "ade": "generalized rash", "drug": "capecitabine" }, { "ade": "itching", "drug": "capecitabine" } ]

Risperidone withdrawal-related respiratory dyskinesia: a case diagnosed by spirography and fibroscopy.

[ { "ade": "respiratory dyskinesia", "drug": "Risperidone" } ]

Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion.

[ { "ade": "Myoglobinuria", "drug": "vasopressin" }, { "ade": "acute renal failure", "drug": "vasopressin" } ]

A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator.

[ { "ade": "behavioral change", "drug": "cinepazide" } ]

Although they had complex medical problems, the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy.

[ { "ade": "seizures", "drug": "ampicillin" } ]

Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.

[ { "ade": "Uveitis", "drug": "rifabutin" }, { "ade": "Uveitis", "drug": "ethambutol" }, { "ade": "Uveitis", "drug": "clarithromycin" } ]

METHODS: A patient who developed dramatic, permanent vision loss after a 9-month course of treatment with ethambutol and isoniazid for pulmonary tuberculosis is presented.

[ { "ade": "vision loss", "drug": "isoniazid" }, { "ade": "vision loss", "drug": "ethambutol" } ]

Toxic optic neuropathy associated with ethambutol: implications for current therapy.

[ { "ade": "Toxic optic neuropathy", "drug": "ethambutol" } ]

The case of an adult who developed both hepatic dysfunction and an impaired macrophage migration after exposure to cimetidine is discussed.

[ { "ade": "hepatic dysfunction", "drug": "cimetidine" }, { "ade": "impaired macrophage migration", "drug": "cimetidine" } ]

We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy.

[ { "ade": "leukopenia", "drug": "AZA" } ]

We report such a series of patients who had transient asymptomatic bradycardia after being treated with continuous infusion 5-FU.

[ { "ade": "transient asymptomatic bradycardia", "drug": "5-FU" } ]

Embolia cutis medicamentosa following subcutaneous injection of glatiramer acetate.

[ { "ade": "Embolia cutis medicamentosa", "drug": "glatiramer acetate" } ]

Reports of colonic perforation as a result of the administration of calcium polystyrene sulfonate and sorbitol are rare.

[ { "ade": "colonic perforation", "drug": "sorbitol" }, { "ade": "colonic perforation", "drug": "calcium polystyrene sulfonate" } ]

Sorafenib induced tumor lysis syndrome in an advanced hepatocellular carcinoma patient.

[ { "ade": "tumor lysis syndrome", "drug": "Sorafenib" } ]

The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.

[ { "ade": "erythema multiforme", "drug": "sulfonamides" }, { "ade": "Stevens-Johnson syndrome", "drug": "sulfonamides" } ]

Lansoprazole-induced thrombocytopenia.

[ { "ade": "thrombocytopenia", "drug": "Lansoprazole" } ]

We report a case of hyperpigmentation due to bleomycin treatment in a patient with acquired immune deficiency syndrome (AIDS).

[ { "ade": "hyperpigmentation", "drug": "bleomycin" } ]

Carbamazepine-induced tics.

[ { "ade": "tics", "drug": "Carbamazepine" } ]

Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.

[ { "ade": "Iatrogenic Cushing syndrome", "drug": "triamcinolone" } ]

Captopril is known to be associated with dermatologic, hematologic, and pulmonary adverse effects.

[ { "ade": "dermatologic, hematologic, and pulmonary adverse effects", "drug": "Captopril" } ]

Nonconvulsive status epilepticus: the role of morphine and its antagonist.

[ { "ade": "Nonconvulsive status epilepticus", "drug": "morphine" } ]

PURPOSE: To describe the clinical and electrophysiological findings in a young boy with decreased vision possibly due to retinal damage by rifabutin.

[ { "ade": "decreased vision", "drug": "rifabutin" }, { "ade": "retinal damage", "drug": "rifabutin" } ]

Furosemide-associated fever.

[ { "ade": "fever", "drug": "Furosemide" } ]

We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.

[ { "ade": "ARDS", "drug": "pegylated interferon alpha-2a" }, { "ade": "ARDS", "drug": "pegIFNalpha-2a" }, { "ade": "ARDS", "drug": "ribavirin" }, { "ade": "adult respiratory distress syndrome", "drug": "ribavirin" }, { "ade": "adult respiratory distress syndrome", "drug": "pegylated interferon alpha-2a" }, { "ade": "adult respiratory distress syndrome", "drug": "pegIFNalpha-2a" } ]

This case report describes a 38-year-old male in whom SIADH was strongly suspected secondary to Tegretol therapy to control a seizure disorder.

[ { "ade": "SIADH", "drug": "Tegretol" } ]

In one case, disulfiram was the only potential teratogen exposed to the fetus.

[ { "ade": "teratogen", "drug": "disulfiram" } ]

A patient developed optic neuropathy while being treated with isoniazid and ethambutol.

[ { "ade": "optic neuropathy", "drug": "isoniazid" }, { "ade": "optic neuropathy", "drug": "ethambutol" } ]

Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication.

[ { "ade": "psychotic decompensations", "drug": "amantadine" } ]

We observed 2 cases of hepatotoxicity after a high-dose methylprednisolone treatment of a demyelinating disease and evaluated the potential relationship in the light of available evidence.

[ { "ade": "hepatotoxicity", "drug": "methylprednisolone" } ]

Experience with five patients in whom impaired renal function developed early during amphotericin B therapy is reported.

[ { "ade": "impaired renal function", "drug": "amphotericin B" } ]

Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature.

[ { "ade": "acute amnestic episode", "drug": "clioquinol" } ]

We describe a 73-year-old woman who developed serious systemic vasculitis with associated thrombocytopenia in the course of treatment with cladribine.

[ { "ade": "systemic vasculitis", "drug": "cladribine" }, { "ade": "thrombocytopenia", "drug": "cladribine" } ]

Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.

[ { "ade": "progressive visual loss", "drug": "MTX" }, { "ade": "death", "drug": "MTX" }, { "ade": "death", "drug": "Ara-C" }, { "ade": "loss of consciousness", "drug": "Ara-C" }, { "ade": "loss of consciousness", "drug": "MTX" }, { "ade": "progressive visual loss", "drug": "Ara-C" } ]

Ezetimibe-induced acute pancreatitis.

[ { "ade": "acute pancreatitis", "drug": "Ezetimibe" } ]

This is the first case of HBV reactivation occurring during the year following rituximab monotherapy in the absence of any other immunosuppressive factor.

[ { "ade": "HBV reactivation", "drug": "rituximab" } ]

Fatal outcome of intravesical formalin instillation, with changes mimicking renal tuberculosis.

[ { "ade": "Fatal outcome", "drug": "formalin" } ]

We report a case of a women in whom a malignant mixed mesodermal tumor was diagnosed while she was taking raloxifene, which is also a selective estrogen receptor modulator.

[ { "ade": "malignant mixed mesodermal tumor", "drug": "raloxifene" } ]

The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia.

[ { "ade": "pericardial hemorrhage", "drug": "acetylsalicylic acid" } ]

In two of these cases akathisia resolved after withdrawal of olanzapine and substitution by a classical or an atypical neuroleptic agent, respectively.

[ { "ade": "akathisia", "drug": "olanzapine" } ]

Interstitial pneumonia probably associated with sorafenib treatment: An alert of an adverse event.

[ { "ade": "Interstitial pneumonia", "drug": "sorafenib" } ]

This report describes a probable case of infliximab-induced membranous nephropathy.

[ { "ade": "membranous nephropathy", "drug": "infliximab" } ]

The first patient developed a monoarthritis 2 weeks after initiation of IFN-beta, which persisted during the 14 months of therapy and resolved with discontinuation of the medication.

[ { "ade": "monoarthritis", "drug": "IFN-beta" } ]

Late development of diabetes mellitus after interferon-alfa and ribavirin therapy for chronic hepatitis C: a case report.

[ { "ade": "diabetes mellitus", "drug": "ribavirin" }, { "ade": "diabetes mellitus", "drug": "interferon-alfa" } ]

We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-elonic seizures.

[ { "ade": "antidiuresis", "drug": "carbamazepine" } ]

This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.

[ { "ade": "multiple nodules in the liver", "drug": "phosphate diethylstilbestrol" }, { "ade": "multiple nodules in the liver", "drug": "PDES" } ]

Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases.

[ { "ade": "Cutaneous sarcoidosis", "drug": "ribavirin" }, { "ade": "Cutaneous sarcoidosis", "drug": "interferon alfa" } ]

Acceleration of ventricular response to atrial flutter after intravenous adenosine.

[ { "ade": "Acceleration of ventricular response", "drug": "adenosine" } ]

The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.

[ { "ade": "skin cancers", "drug": "hydroxyurea" }, { "ade": "painful hand ulcer", "drug": "hydroxyurea" } ]

Other upper tract neoplasms after cyclophosphamide are reviewed.

[ { "ade": "upper tract neoplasms", "drug": "cyclophosphamide" } ]

Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.

[ { "ade": "severe persistent bronchospasm", "drug": "tobramycin" }, { "ade": "recurrent eosinophilia", "drug": "tobramycin" } ]

On the 3rd day, an inferior vena cava (IVC) filter was placed with a heparin flush, after which massive IVC thrombosis developed.

[ { "ade": "IVC thrombosis", "drug": "heparin" } ]

Zoledronic acid-induced severe hypocalcaemia in a prostate cancer patient with extensive osteoblastic bone metastases.

[ { "ade": "severe hypocalcaemia", "drug": "Zoledronic acid" } ]

CONCLUSIONS: Amphotericin B overdose can be fatal in children and infants.

[ { "ade": "fatal", "drug": "Amphotericin B" } ]

While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.

[ { "ade": "ocular effects", "drug": "digoxin" }, { "ade": "visual changes", "drug": "digoxin" }, { "ade": "ocular effects", "drug": "amiodarone" }, { "ade": "visual changes", "drug": "amiodarone" } ]

Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system.

[ { "ade": "neurologic symptoms", "drug": "Acyclovir" } ]

Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.

[ { "ade": "coagulopathy", "drug": "cephalosporin" }, { "ade": "coagulopathy", "drug": "moxalactam" } ]

CONCLUSIONS: We report the first case of gemcitabine-induced LABD.

[ { "ade": "LABD", "drug": "gemcitabine" } ]

Early recognition of hereditary motor and sensory neuropathy type 1 can avoid life-threatening vincristine neurotoxicity.

[ { "ade": "life-threatening vincristine neurotoxicity", "drug": "vincristine" } ]

By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.

[ { "ade": "platelet activation", "drug": "heparin" }, { "ade": "platelet activation", "drug": "Clexane" }, { "ade": "platelet activation", "drug": "Fraxiparin" }, { "ade": "platelet activation", "drug": "Fragmin" } ]