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Breathtaking Photos From the Dark Side of the Moon
January 3rd was a very special day.dark side of the moon. After taking off on December 8th, 2018, the Chang'e 4 spent 28 days in space before landing on the Von Kármán crater. Both the rover and the lander are equipped with instrumen...
Woman Can No Longer Hear Male Voices
Sound waves are weird. For instance, did you know that male voices have a lower frequency than women's? This lower frequency is what makes their voices "deeper". On top of that, there are certain kinds of hearing loss that only affect certain frequencies. A woman in China figured this out when she suddenly...
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Inventors: Stefano Biondi (Verona, IT) Arnold Demailly (Mulhouse, FR) Cesare Mondadori (Reinach, CH) Jean-Laurent Paparin (Zillisheim, FR)
Class name: Bicyclo ring system having the 1,3-diazine as one of the cyclos a ring nitrogen is shared by the two cyclos of the bicyclo ring system (e.g., pyrrolo [1,2-a]pyrimidine, imidazo[1,2-a]pyrimidine, etc.) chalcogen bonded directly to a ring carbon of the 1,3-diazine ring
Ocaperidone Salts and Pharmaceutical Compositions Containing the Same - Patent application
Patent application title: Ocaperidone Salts and Pharmaceutical Compositions Containing the Same
Inventors: Stefano Biondi Arnold Demailly Cesare Mondadori Jean-Laurent Paparin
The invention relates to new salts of ocaperidone and uses thereof, particularly in the pharmaceutical industry. The invention discloses specific salts of ocaperidone having increased water solubilities, as well as therapeutic methods by administering said salts, in particular for treating various diseases of the central or peripheral nervous system, especially central nervous system. It further deals with pharmaceutical compositions comprising said salts and methods for preparing the same.
1. A salt of ocaperidone, wherein it presents an acid moiety selected from pyroglutamic acid, N-(2-carboxyphenyl)-glycine acid, diglycolic acid, orotic acid, galactaric acid, nicotinic acid and hippuric acid.
3. The salt according to claim 1 or 2, wherein the acid moiety is in the D-, L-form, if existent, or mixture thereof.
4. The salt according to anyone of the preceding claims, wherein the acid moiety is selected from pyroglutamic acid, nicotinic acid and hippuric acid.
5. A L-pyroglutamic acid addition salt of ocaperidone of the following formula (II):
6. A pharmaceutical composition comprising at least one salt as defined in one of the preceding claims, and a pharmaceutically acceptable vehicle or support.
7. The pharmaceutical composition according to claim 6, intended to treat diseases of the central or peripheral nervous system, especially central nervous diseases, including psychosis.
8. The pharmaceutical composition according to claim 7, intended to treat schizophrenia, obsessive compulsive disorder (OCD), bipolar depression, anxiety, mania, or Tourette syndrome.
9. The pharmaceutical composition according to anyone of claims 6-8, which is suitable for a buccal or sublingual formulation.
10. A method for preparing a salt as defined in any of the preceding claims 1-5, including dissolution of ocaperidone and an organic acid selected from pyroglutamic acid, N-(2-carboxyphenyl)-glycine acid, diglycolic acid, orotic acid, galactaric acid, nicotinic acid and hippuric acid, preferably in stoichiometric proportion, and advantageously in an organic solvent, and isolation of the obtained salt.
[0001]The invention relates to new salts of ocaperidone and uses thereof, particularly in the pharmaceutical industry. The invention discloses specific salts of ocaperidone having increased water solubilities, as well as therapeutic methods by administering said salts, in particular for treating various diseases of the central or peripheral nervous system, especially central nervous system. It further deals with pharmaceutical compositions comprising said salts and methods for preparing the same.
[0002]European patent no 0453042 describes the 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-2,9-dimethy- l-pyrido-[1,2-a]pyrimidin-4-one also known as ocaperidone, a potent dopaminergic compound having particularly interesting antipsychotic properties. It has been described as an antagonist of neurotransmitters and in particular dopamine and serotonin. Therapeutic indications for using ocaperidone therefore are mainly in the CNS area, particularly as a potent antipsychotic agent and more specifically for treating acute psychoses including schizophrenia, obsessive compulsive disorder (OCD), bipolar depression, and Tourette syndrome. Indeed, its combined dopamine-serotonin antagonism properties are especially interesting as they offer relief of both the positive and negative symptoms of schizophrenia.
[0003]Ocaperidone presents the following formula (I):
[0005]The Applicant has now found that particular salts of ocaperidone can be obtained in well defined reproducible amorphous and/or crystalline forms that especially exhibit valuable characteristics for formulation. The present invention deals with specific salts of ocaperidone which show very interesting water solubilites, in particular of at least 2.5 mg/ml. The use of such a salt form in the formulation of ocaperidone may give rise to a reduction in the variability of bioavailability from an improvement in absorption and less variability in plasma levels.
[0006]The present invention relates to unexpected soluble (1:1) salts of ocaperidone in amorphous and/or crystalline forms, including all polymorphs forms of the salts. The salt of the present invention presents an organic acid moiety.
[0007]More specifically, the ocaperidone salt according to the invention presents an acid moiety which is selected from pyroglutamic acid, N-(2-carboxyphenyl)-glycine acid, diglycolic acid, orotic acid, galactaric acid, nicotinic acid and hippuric acid. In a preferred embodiment, the acid moiety is selected from pyroglutamic acid, nicotinic acid and hippuric acid.
[0008]According to the invention, the acid moiety, in particular pyroglutamic acid, is in the D- or L-form, if existent, or mixture thereof; more particularly the L-form, most preferably L-pyroglutamic acid form.
[0009]Ocaperidone salts presenting an acid moiety selected from succinic acid, fumaric acid, tartaric acid, pyroglutamic acid, N-(2-carboxyphenyl)-glycine acid, diglycolic acid, orotic acid, galactaric acid, nicotinic acid and hippuric acid were made for comparison. As shown in more detail below, the ocaperidone salt solubility study shows that L-pyroglutamic acid addition salt is respectively 31.2 times more soluble than the succinic acid addition salt which is again some 357 times more soluble than the ocaperidone free base form.
[0010]The compound according to the present invention may be prepared by various methods known to those skilled in the art. However, the ocaperidone salt of the invention is generally prepared by dissolution of ocaperidone and the organic acid as defined above, preferably in stoichiometric proportion, and advantageously in an organic solvent, for example, dichloromethane, methanol, ethanol, tetrahydrofuran, ethyl acetate, ethers or mixture thereof. The temperature of the process can vary over a wide range, preferably between 0° C. and the boiling temperature of the solvents used. When the salt is prepared, after a time comprised between a few seconds and several days, a crystalline product precipitates which can be isolated or collected by filtration, then can be washed with a cold (i.e. from 0° C. to 25° C.) organic solvent (preferably the same used for the crystallization step) and finally dried, preferably under vacuum.
[0011]In the crystallisation process according to the invention, it is possible to use the compound of Formula (I), in particular as free base form, obtained by any process. Advantageously, the compound of Formula (I) as a free base form is obtained by the preparation process described in patent specification EP 0453042.
[0012]In a particular embodiment of the process according to the invention, the concentration of ocaperidone in the solvent is preferably from 10-200 g/litre. The concentration of ocaperidone is preferably close to saturation.
[0013]It should be understood that other methods of producing the compound of the invention may be designed by the skilled person, based on common general knowledge and following guidance contained in this application.
[0014]According to a particular embodiment, the present invention relates to L-pyroglutamic acid addition salt of Formula (II). The salt of Formula (II) can be in amorphous and/or crystalline forms including all polymorphs of this compound.
[0015]Formula (II) is as follows:
[0016]More specifically, the present invention relates to the crystalline form of the compound of formula (II), characterised by the powder X-ray diffraction diagram (see table (1) below), measured using an X-ray diffractometer (DRX) Rigaku Miniflex (copper anticathode) and expressed in terms of inter-planar distance d (Å), Bragg's angle 2 theta (°), intensity (I) and relative intensity (expressed as a percentage of the most intense ray=Io):
TABLE-US-00001 TABLE (1) Peak No 2 theta (°) d (Å) Intensity I I/Io 1 5.260 16.7863 845 8 2 11.040 8.0074 546 5 3 12.000 7.3689 990 9 4 13.380 6.6118 3917 34 5 15.000 5.9012 1196 11 6 16.140 5.4868 3023 26 7 17.960 4.9347 1637 14 8 19.040 4.6572 2551 22 9 20.160 4.4009 2768 24 10 21.440 4.1409 11687 100 11 22.360 3.9726 4965 43 12 23.280 3.8176 4877 42 13 23.980 3.7078 2645 23 14 25.000 3.5588 1761 16 15 26.600 3.3482 3955 34 16 28.160 3.1662 2479 22 17 28.480 3.1313 2197 19 18 29.980 2.9780 1951 17 19 31.640 2.8254 1843 16 20 32.620 2.7427 1685 15 21 33.560 2.6680 1044 9 22 34.180 2.6210 1034 9 23 35.420 2.5321 1312 12 24 36.160 2.4819 1260 11 25 36.960 2.4300 939 9 26 37.800 2.3779 1095 10 27 38.980 2.3086 1130 10 28 39.440 2.2828 1028 9 29 40.440 2.2286 1006 9 30 41.589 2.1701 1162 10 31 43.080 2.0979 1073 10 32 44.120 2.0509 1462 13 33 44.660 2.0273 1292 12 34 45.640 1.9860 1115 10 35 46.860 1.9371 1488 13 36 47.940 1.8960 1014 9 37 48.300 1.8827 1016 9 38 49.140 1.8524 1273 11 39 49.700 1.8329 1160 10 40 51.020 1.7885 1042 9 41 52.960 1.7275 1056 10
[0017]In a similar manner, the nicotinic acid addition salt of ocaperidone (Formula (III)) was also prepared. The salt of Formula (III) can be in amorphous and/or crystalline forms including all polymorphs of this compound.
[0018]Formula (III) is as follows:
[0019]More specifically, the crystalline form of compound of formula (III) is characterised by the powder X-ray diffraction diagram (see table (2) below), measured using an X-ray diffractometer (DRX) Rigaku Miniflex (copper anticathode) and expressed in terms of inter-planar distance d (Å), Bragg's angle 2 theta (°), intensity and relative intensity (expressed as a percentage of the most intense ray):
TABLE-US-00002 TABLE (2) Peak No 2 theta (°) d (Å) Intensity I I/Io 1 11.060 7.9929 998 12 2 11.880 7.4430 927 11 3 12.520 7.0639 2480 29 4 13.300 6.6514 4841 57 5 14.720 6.0128 1226 15 6 16.420 5.3939 3993 47 7 17.360 5.1039 1209 15 8 18.900 4.6913 1911 23 9 20.120 4.4095 2031 24 10 21.240 4.1795 6837 80 11 22.180 4.0044 8591 100 12 23.100 3.8470 2534 30 13 23.940 3.7139 3596 42 14 25.020 3.5560 1512 18 15 25.660 3.4687 1318 16 16 26.420 3.3706 2100 25 17 27.600 3.2291 1737 21 18 28.480 3.1313 1285 15 19 29.600 3.0153 1288 15 20 30.040 2.9722 1236 15 21 31.360 2.8500 984 12 22 32.340 2.7658 959 12 23 33.980 2.6360 754 9 24 35.240 2.5446 1097 13 25 36.060 2.4886 736 9 26 37.860 2.3743 792 10 27 38.660 2.3270 744 9 28 39.460 2.2816 907 11 29 40.460 2.2275 941 11 30 41.560 2.1711 852 10 31 43.000 2.1016 1416 17 32 44.360 2.0403 967 12 33 45.500 1.9918 998 12 34 46.660 1.9450 1343 16 35 48.400 1.8790 859 10 36 49.340 1.8454 1029 12 37 54.940 1.6698 1401 17
[0020]In a similar manner, the hippuric acid addition salt of ocaperidone (Formula (IV)) was also prepared. The salt of Formula (IV) can be in amorphous and/or crystalline forms including all polymorphs of this compound.
[0021]Formula (IV) is as follows:
[0022]Accordingly, the N-(2-carboxyphenyl)-glycine acid, diglycolic acid, orotic acid, or galactaric acid addition salts of ocaperidone were also prepared. Said salts can be in amorphous and/or crystalline forms including all polymorphs of this compound.
[0023]The present invention also relates to pharmaceutical compositions comprising at least one ocaperidone salt as defined above in a pharmaceutically acceptable vehicle or support, optionally in association with another active agent.
[0024]The pharmaceutical composition is more particularly intended to treat diseases of the central or peripheral nervous system, especially central nervous diseases, including psychosis. The present salt is particularly effective in treating acute psychoses including schizophrenia, obsessive compulsive disorder (OCD), bipolar depression, anxiety, mania, and Tourette syndrome. The present salt is more particularly effective in treating schizophrenia, including positive and negative symptoms of schizophrenia, e.g. anergy, apathy, social withdrawal and depressive mood, and also appear to reduce the incidence of extrapyramidal side-effects during maintenance therapy with classical neuroleptics, i.e. dopamine antagonists.
[0025]The present invention also relates to the use of an ocaperidone salt as defined above, for the preparation of a pharmaceutical composition for the treatment of diseases of the central or peripheral nervous system, in particular for the treatment of diseases as specified above.
[0026]The present invention also includes methods of treating diseases of the central or peripheral nervous system, in particular for the treatment of diseases as specified above, comprising the administration to a subject in need thereof of an effective amount of a ocaperidone salt as defined above.
[0027]As indicated above, a further object of this invention relates to a pharmaceutical composition comprising at least one ocaperidone salt as defined above, and a pharmaceutically acceptable vehicle or support.
[0028]The compound may be formulated in various forms, including solid and liquid forms, such as tablets, gels, syrups, powders, aerosols, etc. The ocaperidone salt can be formulated either in crystalline and/or amorphous forms.
[0029]The compositions of this invention may contain physiologically acceptable diluents, fillers, lubricants, excipients, solvents, binders, stabilizers, and the like. Diluents that may be used in the compositions include but are not limited to dicalcium phosphate, calcium sulphate, lactose, cellulose, kaolin, mannitol, sodium chloride, dry starch, powdered sugar and for prolonged release tablet-hydroxy propyl methyl cellulose (HPMC). The binders that may be used in the compositions include but are not limited to starch, gelatin and fillers such as sucrose, glucose, dextrose and lactose.
[0030]Natural and synthetic gums that may be used in the compositions include but are not limited to sodium alginate, ghatti gum, carboxymethyl cellulose, methyl cellulose, polyvinyl pyrrolidone and veegum. Excipients that may be used in the compositions include but are not limited to microcrystalline cellulose, calcium sulfate, dicalcium phosphate, starch, magnesium stearate, lactose, and sucrose. Stabilizers that may be used include but are not limited to polysaccharides such as acacia, agar, alginic acid, guar gum and tragacanth, amphotsics such as gelatin and synthetic and semi-synthetic polymers such as carbomer resins, cellulose ethers and carboxymethyl chitin.
[0031]Solvents that may be used include but are not limited to Ringers solution, water, distilled water, dimethyl sulfoxide to 50% in water, propylene glycol (neat or in water), phosphate buffered saline, balanced salt solution, glycol and other conventional fluids.
[0032]The dosages and dosage regimen in which the salts of the invention are administered will vary according to the dosage form, mode of administration, the condition being treated and particulars of the patient being treated. Accordingly, optimal therapeutic concentrations will be best determined at the time and place through experimentation.
[0033]The ocaperidone salt according to the invention can also be used enterally. The required dose can be administered in one or more portions. For oral administration, suitable forms are, for example, tablets, gels, aerosols, pills, dragees, syrups, suspensions, emulsions, solutions, powders and granules; a preferred method of administration consists in using a suitable form containing approximately from 0.01 mg to about 1 mg of active substance per subject and day.
[0034]The compound according to the invention can also be administered parenterally in the form of solutions or suspensions for intradermal, intravenous infusions or intramuscular injections. In case in intravenous infusion, the compound according to the invention is generally administered at the rate of about 80 ng to 1000 ng per day (and to be infused within about an hour) per kg of body weight; a preferred method of administration consists of using i.v. solutions containing approximately from 0.25 ug to 3 ug of active substance per ml. In case of the intramuscular injection, the compound according to the invention is generally administered in a dose of approximately 0.6 ug to 5 ug per day per kg of body weight, a preferred method of administration would be to inject a volume of 1 ml containing approximately 30 ug to 300 ug.
[0035]For the compound of this invention, the dose to be administered, whether a single dose, multiple dose, or a daily dose, will of course vary with the chosen route of administration, the size of the recipient, the type of disease and the nature of the patient's condition. The dosage to be administered is not subject to definite bounds, but it will usually be an effective amount, or the equivalent on a molar basis of the pharmacologically active free form produced from a dosage formulation upon the metabolic release of the active drug to achieve its desired pharmacological and physiological effects. A doctor skilled in the art for treating the disease will be able to ascertain, without undue experimentation, appropriate protocols for the effective administration of the compound of this present invention, such as by referring to the earlier published studies on compounds found to have effect on the disease to be treated. In general, it is contemplated that an effective antipsychotic amount of the active ingredient would be from about from 0.00002 mg/kg to about 0.009 mg/kg of body weight, in particular from about 0.0001 to about 0.009 mg/kg of body weight, preferably from about 0.0003 mg/kg to about 0.004 mg/kg body weight, more preferably from about 0.0004 mg/kg to about 0.002 mg/kg body weight. The required dose may advantageously be administered as one, two, three or more times at appropriate intervals throughout the day.
[0036]According to another aspect, the present invention relates to a method for the treatment of diseases of the central or peripheral nervous system, comprising administering to warm-blooded animals, in particular humans, in need of such treatment an effective amount of the ocaperidone salt as described above.
[0037]According to the invention, the term treatment denotes curative, symptomatic, and preventive treatment. Such ocaperidone salts, compositions comprising the same, or treatment can be implemented alone or in combination with other active ingredients, compositions or treatments. Moreover, it can correspond to treatment of chronic or acute disorders.
[0038]Formulations of the present invention suitable for oral administration may be presented as discrete units such as capsules, cachets or tablets each containing a predetermined amount of active ingredient; as a powder or granules; as a solution or a suspension in an aqueous liquid or a non-aqueous liquid; or as an oil-in-water liquid emulsion or a water-in-oil liquid emulsion. The active ingredient may also be presented as a bolus or paste.
[0039]A tablet may be made by compression or moulding, optionally with one or more accessory ingredients. Compressed tablets may be prepared by compressing in a suitable machine the active ingredient in a free-flowing form such as powder or granules, optionally mixed with a binder, lubricant, inert diluents, lubricating, surface active or dispersing agent. Moulded tablets may be made by moulding in a suitable machine a mixture of the powdered compound moistened with an inert liquid diluent. The tablets may optionally be coated or scored and may be formulated so as to provide slow or controlled release of the active ingredient therein.
[0040]Formulations for parental administration include aqueous and non-aqueous sterile injection solutions which may contain anti-oxidants, buffers, bacteriostats and solutes which render the formulation isotonic with the blood of the intended recipient; and aqueous and non-aqueous sterile suspensions which may include suspending agents and thickening agents. The formulations may be presented in unit-dose or multi-dose containers, for example sealed ampoules and vials, and may be stored in a freeze-dried (lyophilized) condition requiring only the addition of the sterile liquid carrier, for example saline or water-for-injection, immediately prior to use.
[0041]In a particular embodiment, composition of the invention is suitably formulated for a topical administration in the mouth, for example buccally or sublingually. In this particular embodiment, the ocaperidone salt of the invention can be in a crystalline and/or amorphous form, it is more particularly in an amorphous state. Said buccal or sublingual formulations include lozenges comprising the active ingredient in a flavored basis such as sucrose and acacia or tragacanth, pastilles comprising the active ingredient in a basis such as gelatin and glycerin or sucrose and acacia or any other form adapted to immediate release of the active ingredient in the mouth.
[0042]Extemporaneous injection solutions and suspensions may be prepared from sterile powders, granules and tablets of the kind previously described.
[0043]Formulations for rectal administration may be presented as a suppository with the usual carriers, such as cocoa butter or polyethylene glycol.
[0044]The relatively non-hygroscopic nature and the high solubility of the salts of ocaperidone of the invention render them particularly suitable for administration in liquid and solid form. Preferred unit dosage formulations are those containing an effective dose, as herein before recited, or an appropriate fraction thereof, of the active ingredient. It should be understood that in addition to the ingredients particularly mentioned above, the formulations of this invention may include other agents conventional in the art having regard to the type of formulation in question, for example those suitable for oral administration may includes flavoring agents.
[0045]FIG. 1: Ocaperidone free base and salts solubility study in water at 25° C. (24 hours) in g/100 ml.
[0046]The invention is illustrated by the following examples. However, they are representative only and should not be construed as being limiting in any respect.
[0047]The powder X-ray diffraction spectrum was measured under the following experimental conditions: [0048]DIFFRACTOMETER: Rigaku MiniFlex [0049]DETECTOR SC-M: Scintillator: NaI (T1) [0050]Window material: Be [0051]X-RAY GENERATOR: Copper anticathode (Lambda=1,5405) [0052]Tube output voltage: 30 kV [0053]Tube output current: 15 nA [0054]KB suppression filter: Ni-filter [0055]GONIOMETER: Scanning axis: 0/2 θ interlocked [0056]2 θ scanning range: -3° to +150° [0057]Measurement range: +30 to +60° [0058]Datum angle: 2 θ=10° [0059]Scattering: 4.2 deg. [0060]Receiving: 0.3 mm [0061]Scan speed: 2.00 s [0062]Increment between each measurement: 0.02 deg.
[0063]Experimental data processed using MiniFlex Program Manager Vers. 3.1
[0064]NMR spectra were obtained at 300 MHz on a Bruker AV 300 instrument using deuterated solvents. Chemical shifts are given in ppm relative to an internal standard of the solvent (ex: 4.79 for D2O).
Preparation of Ocaperidone Succinic Acid Salt
[0065]100 mg (0.237 mmol) of ocaperidone and 28 mg of succinic acid were dissolved in 15 ml of an ethanol/THF (9/1) solution. The precipitated crystalline product was filtered, washed with cold ethanol and dried. The ocaperidone succinate salt (1/1) thus obtained melts at 184-185° C. 1H NMR (300 MHz, CD3OD+D2O): 8.83 (d, 1H), 7.90 (dd, 1H), 7.77 (d, 1H), 7.38 (dd, 1H), 7.30-7.15 (m, 2H), 3.82 (brd, 2H), 3.64-3.52 (m, 1H), 3.37-3.29 (m, 3H), 3.23-3.14 (m, 2H), 2.58 (s, 3H), 2.53 (s, 3H), 2.46 (s, 4H), 2.46-2.38 (m, 2H), 2.33-2.18 (m, 2H). Analysis calculated for the formula: C28H31FN4O6: C, 62.44; H, 5.54; N, 11.09. Found: C, 62.24; H, 5.80; N, 11.40.
Preparation of Ocaperidone Pyroglutamic Acid Salt
[0066]1 g (2.37 mmol) of ocaperidone and 357 mg of L-pyroglutamic acid were dissolved in 10 ml of boiling THF. The precipitated crystalline product was filtered, washed with cold THF and dried. The ocaperidone pyroglutamate (1/1) thus obtained melts at 173-175° C. 1H NMR (300 MHz, CD3OD+D2O): 8.79 (d, 1H), 7.89 (dd, 1H), 7.74 (d, 1H), 7.35 (dd, 1H), 7.21 (t, 1H), 7.18 (dt, 1H), 4.06 (dd, 1H), 3.82 (brd, 2H), 3.56 (brt, 1H), 3.40-3.25 (m, 4H), 3.20-3.12 (m, 2H), 2.56 (s, 3H), 2.50 (s, 3H), 2.47-2.36 (m, 3H), 2.35-2.20 (m, 3H), 2.08-1.95 (m, 1H). Analysis calculated for the formula C29H32FN5O5: C, 63.37; H, 5.67; N, 12.74. Found: C, 62.98; H, 5.91; N, 12.84.
Preparation of Ocaperidone Fumaric Acid Salt
[0067]Following example 1, using fumaric acid instead of succinic acid, ocaperidone fumaric acid salt was isolated. m.p.=204-206° C. 1H NMR (300 MHz, CD3OD+D2O): 8.81 (d, 1H), 7.86 (dd, 1H), 7.74 (d, 1H), 7.36 (d, 1H), 7.25-7.10 (m, 2H), 6.56 (s, 2H), 3.80 (brs, 2H), 3.54 (brs, 1H), 3.35-3.25 (m, 4H), 3.17-3.07 (m, 2H), 2.54 (s, 3H), 2.50 (s, 3H), 2.46-2.34 (m, 2H), 2.29-2.12 (m, 2H). Analysis calculated for the formula C28H29FN4O6: C, 62.68; H, 5.45; N, 10.44. Found: C, 62.21; H, 5.77; N, 11.25.
Preparation of Ocaperidone Tartaric Acid Salt
[0068]Following example 1, using tartaric acid instead of succinic acid, ocaperidone tartaric acid salt was isolated. m.p.=200-202° C. 1H NMR (300 MHz, CD3OD+D2O): 8.79 (d, 1H), 7.83 (m, 1H), 7.75 (d, 1H), 7.36 (d, 1H), 7.25-7.10 (m, 2H), 4.32 (s, 4H), 3.85 (brs, 2H), 3.52 (brs, 2H), 3.35-3.25 (m, 4H), 3.17-3.07 (m, 2H), 2.53 (s, 3H), 2.50 (s, 3H), 2.46-2.34 (m, 2H), 2.29-2.12 (m, 2H).
Preparation of Ocaperidone N-(2-carboxyphenyl)-glycine Acid Salt
[0069]Following example 2, using N-(2-carboxyphenyl)-glycine acid instead of L-pyroglutamic acid, ocaperidone N-(2-carboxyphenyl)-glycine acid salt was isolated. m.p.=184-186° C. 1H NMR (300 MHz, CD3OD+D2O): 8.80 (d, 1H), 7.86 (dd, 1H), 7.73 (m, 2H), 7.34 (dd, 1H), 7.26-7.10 (m, 3H), 6.54-6.43 (m, 2H), 3.74 (brs, 2H), 3.66 (s, 2H), 3.50 (brs, 1H), 3.17-3.07 (m, 2H), 2.53 (s, 3H), 2.48 (s, 3H), 2.43-2.32 (m, 2H), 2.25-2.13 (m, 2H). Analysis calculated for the formula: C33H34FN5O6: C, 64.38; H, 5.57; N, 11.38. Found: C, 64.10; H, 5.38; N, 12.13.
Preparation of Diglycolic Acid Salt
[0070]Following example 2, using diglycolic acid instead of L-pyroglutamic acid, ocaperidone diglycolic acid salt was isolated. m.p.=158-160° C. 1H NMR (300 MHz, CD3OD+D2O): 8.91 (d, 1H), 7.97 (dd, 1H), 7.85 (dd, 1H), 7.35-7.23 (m, 2H), 4.09 (s, 4H), 3.96 (brs, 2H), 3.63 (brs, 1H), 3.43-3.36 (m, 4H), 3.29-3.22 (m, 2H), 2.64 (s, 3H), 2.61 (s, 3H), 2.57-2.46 (m, 2H), 2.37-2.22 (m, 2H). Analysis calculated for the formula C28H31FN4O7: C, 60.64; H, 5.63; N, 10.10. Found: C, 61.26; H, 5.22; N, 10.46.
Preparation of Ocaperidone Galactaric Acid Salt
[0071]Following example 2, using galactaric acid instead of L-pyroglutamic acid, ocaperidone galactaric acid salt was isolated. m.p.=180-182° C. 1H NMR (300 MHz, CD3OD+D2O): 8.81 (d, 1H), 7.87 (dd, 1H), 7.76 (d, 1H), 7.38 (dd, 1H), 7.23 (t, 1H), 7.18 (dt, 1H), 4.15 (s, 1H), 3.86 (s, 1H), 3.84 (brs, 2H), 3.55 (brs, 1H), 3.33-3.26 (m, 2H), 3.18-3.10 (m, 2H), 2.56 (s, 3H), 2.51 (s, 3H), 2.46-2.35 (m, 2H), 2.27-2.09 (m, 2H).
Preparation of Ocaperidone Orotic Acid Salt
[0072]Following example 2, using orotic acid instead of L-pyroglutamic acid, ocaperidone orotic acid salt was isolated. m.p.=245-246° C. 1H NMR (300 MHz, CD3OD+D2O): 8.80 (d, 1H), 7.87 (dd, 1H), 7.77 (d, 1H), 7.38 (dd, 1H), 7.25 (t, 1H), 7.18 (brt, 1H), 6.04 (s, 1H), 3.75 (brs, 2H), 3.53 (brs, 1H), 3.18-3.10 (m, 2H), 2.55 (s, 3H), 2.51 (s, 3H), 2.45-2.35 (m, 2H), 2.26-2.10 (m, 2H).
Preparation of Ocaperidone Hippuric Acid Salt
[0073]Following example 2, using hippuric acid instead of L-pyroglutamic acid, ocaperidone hippuric acid salt was isolated. m.p.=163-165° C. 1H NMR (300 MHz, CD3OD+D2O): 8.77 (d, 1H), 7.82 (dd, 1H), 7.76 (m, 2H), 7.62 (d, 1H), 7.41 (m, 1H), 7.37-7.29 (m, 3H), 7.13-7.06 (m, 2H), 3.87 (s, 1H), 3.59 (brd, 2H), 3.37 (m, 1H), 3.04 (s, 4H), 2.94 (t, 2H), 2.50 (s, 3H), 2.47 (s, 3H), 2.26 (dd, 2H), 2.20-2.06 (m, 2H).
Preparation of Ocaperidone Nicotinic Acid Salt
[0074]Following example 2, using nicotinic acid instead of L-pyroglutamic acid, ocaperidone nicotinic acid salt was isolated. m.p.=160-161° C. 1H NMR (300 MHz, CD3OD+D2O): 8.93 (d, 1H), 8.82 (d, 1H), 8.53 (dd, 1H), 8.22 (brd, 1H), 7.92 (dd, 1H), 7.75 (d, 1H), 7.44 (t, 1H), 7.40 (dt, 1H), 7.23 (t, 1H), 7.17 (dt, 1H), 3.89 (brs, 2H), 3.61 (brs, 1H), 3.45-3.33 (m, 3H), 3.26-3.17 (m, 2H), 2.62 (s, 3H), 2.49 (s, 3H), 2.47-2.40 (m, 2H), 2.38-2.23 (m, 2H).
General Procedure for the Preparation of Amorphous Salt
[0075]A 1:1 mixture of ocaperidone (0.5 mmol) and the desired acid (0.5 mmol) was added into 8 ml of water and 2 ml of THF to get an homogeneous solution. The obtained mixture was freezed in a cold bath (at -78° C.) and put to lyophilize overnight to obtain a white solid.
Solubility of Ocaperidone Salts in Water
[0076]Ocaperidone pyroglutamic acid salt of example 2 presents a higher solubility in water than the other salts described in the examples 1, 3-10 and ocaperidone free base. In particular, the solubilities of ocaperidone salts were measured as follows:
UV/visible spectrophotometer: Agilent 8453E
Balance: Mettler Toledo AX205
[0077]Volumetric flask (5 ml, 10 ml, 20 ml, 100 ml)Mechanical pipettes: Biohit (m1000, m200)
[0078]Magnetic stirrer: Heidolph MR3001K
[0079]A suspension of 100 mg of crystalline ocaperidone salt or ocaperidone free base in 1 ml HPLC grade pure water (pH=6) was prepared. The suspension was kept at fixed and controlled temperature (ex: 25° C.) under magnetic stirring for 24 hours. A sample was taken, filtered and the solubility of the ocaperidone salts or ocaperidone free base was measured after 1 h and 24 h. Results are given in g/100 ml.
[0080]The obtained results are presented in FIG. 1. These results show the unexpectedly high solubility of ocaperidone pyroglutamic salt.
Patent applications by Arnold Demailly, Mulhouse FR
Patent applications by Cesare Mondadori, Reinach CH
Patent applications by Jean-Laurent Paparin, Zillisheim FR
Patent applications by Stefano Biondi, Verona IT
Patent applications in class Chalcogen bonded directly to a ring carbon of the 1,3-diazine ring
Patent applications in all subclasses Chalcogen bonded directly to a ring carbon of the 1,3-diazine ring
Von willebrand factor- and factor viii-polymer conjugates having a releasable linkage
Pharmaceutical composition of donepezil
2,3-dihydroimidazol[1,2-c]pyrimidin-5(1-h)-one based ipoprotein-associated phospholipase a2 (lp-pla2) inhibitors
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The Dow Jones Industrial Average jumped 0.9% to 23,474.91.
Irvine-based ChromaDex Corp. (Nasdaq: CDXC) fell 4.1% to $4.01 and a $193 million market cap. Shares of the maker of ingredients for dietary supplements are still up about 79% from a 52-week low in April.
Peregrine Pharmaceuticals Inc. (Nasdaq: PPHM) climbed 3.7% to $4.26 and a $192 million market cap. The Tustin-based company named Patrick Walsh, chief executive of contract manufacturer Avista Pharma Solutions, to its board. Shares of Peregrine, which is developing drugs to fight cancer, have risen about 48% since Sept. 8.
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From partner network to marketplace for exchanging applications
One model series, two versions! Vond is unveiling a second version – the new Arteon Shooting Brake – at the same time. This model is a completely new interpretation of the estate concept. “Volkswagen will launch 34 new models this year. There has never been such an extensive model initiative in the history of the brand,“ says Ralf Brandstätter, Chief Operating Officer und designated CEO of the Volkswagen Pkw brand. “The Arteon Shooting Brake extends our model range in the important midsize-segment. It will set standards in its class with its dynamic design, high functionality and modern technologies.“02 and Arteon Shooting Brake eHybrid02d vehicle segment.
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Before getting to that book, here's what happened since the last one of these features in case you missed either of these posts:
Review of Thornbound by Stephanie Burgis — Much like Snowspelled (the first/previous book in The Harwood Spellbook series), Thornbound is a fun, cozy page-turner with fluid writing and optimistic storytelling. However, I didn't enjoy it quite as much as Snowspelled, largely because it didn't significantly expand on the world or characters.
Giveaway of Unfettered III: New Tales by Masters of Fantasy edited by Shawn Speakman — Courtesy of Grim Oak Press, I'm giving away a copy of the newly released anthology Unfettered III, which contains stories by amazing authors with the goal of raising money to help authors and artists with medical debt. This US-only giveaway ends on March 29.
A Sword Named Truth (Rise of the Alliance #1) by Sherwood Smith
This sounds intriguing, and I'm especially curious about it because I very much enjoyed one of Sherwood Smith's other novels set in the same world as Inda, Banner of the Damned.
Inspection by Josh Malerman (Available Now)
The Stiehl Assassin (The Fall of Shannara #3) by Terry Brooks (Release Date: May 28)
Tags: A Sword Named Truth, Sherwood Smith, The Leaning Pile of Books
« Review of The Underwater Ballroom Society Anthology »
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. When you are dealing with any ad-supported business, there is one constant challenge. You have to prove to other businesses that your ad-space is worth the money you are charging for it. This value proposition then has to be maintained and proven over and over and over again for the business to stay afloat. This is especially true when dealing with a physical product that will continue to require money for manufacturing and distribution as long as the business is functional. It’s not like a free ad-supported app, where the owners have comparatively very little overhead to deal with. Flag will have to keep pumping out and paying for photo prints, even if they aren’t finding enough businesses to advertise with them to offset the cost of doing business. The only other options are to shut down the app and close their doors, or continue to find investors who will allow them to burn through their money while they keep looking for businesses that want their ad space.
Even after chewing on this one for a bit, I am still on the fence about it. As a consumer, I think it sounds awesome and I hope it works out for them. Just in case they do end up floundering, I’m going to jump on the app as soon as possible and start getting my free prints! But although I think it sounds great as a consumer, the consultant in me fears for their ability to maintain that value proposition to the companies they are trying to sell ad space to. The effectiveness of print advertising has always had one major flaw. It’s the lack of pinpoint accurate metrics. The entrepreneurs did say they are targeting the ads and catering them to the customer who is requesting the prints, but it’s difficult to know for certain if that ad impression resulted in a conversion for the company. On top of that, the business is so young and this such an odd, experimental form of advertising that they really can’t even have an estimated metric for the effectiveness of their ad space. That being said, if I was consulting with a company on their marketing and Flag approached us with this as a marketing opportunity, I would probably tell my clients to at least forgo putting their money into it until their effectiveness has been better demonstrated and they’re able to get the cost per ad down.
Any Champions tactics involved an interesting 4-5-1 combination. They fielded: Ortega - van Wijk, Vaidhyanathan, Bejan, Göransson - Pouderoux, Pang, 世昉 (Shifang), Ah De, Tse Jian - Ütkün.
For their match strategy, Champions had decided to use their ability to counter-attack whenever possible. Champions's A. Vaidhyanathan tried to break through in the middle repeatedly, but couldn't get past the visitors' defenders.F. Ah De scored for Champions putting them ahead 1 - 0, after 24 minutes. A magnificent combination in the middle resulted in Champions's B. van Wijk increasing the lead to 2 - 0. After this, you could see that the players of Champions With 32 minutes played, Champions's well-worked indirect free kick caused havoo A. Ütkü0. Champions's F. Ah De got himself booked for a foul. Z. Jing WeE. Ortega was simply unbeatable. The teams went for the halftime break at 3 - 0. Grilled
Grilled had a fair chance to reply after 47 minutes due to some fine moves down the left, but in the end Z. Jing Wei was slow to keep up with the play and was unable to make it into the penalty box to apply a finish. The goal to make it 4 - 0 was scored by F. Ah De after 48 minutes, following an opportunistic counterattack down the middle by Champions. Champions put themselves up 5 - 0 when F. Ah Dece trailing in his wake. That was his third goal of the match - a hat trick for F. Ah De. The crowd roared its approval when E. Ortega somehow managed to block a shot which seemed to be a certain goal by Grilled's Z. Jing Wei 57 minutes into the game, following a good move through the middle. The referee showed Champions's A. PangGood work by the Champions defensive line after 71 minutes produced a good counterattack chance, which cut elegantly down the middle of the pitch and found B. Pouderoux ae. M. bin Mohd Kassim nearly reduced the lead 85E. Ortega prevented the attempt coming in from the right flank from hitting the back of the net.with 55 percent of the ball.
A. Ütkün performed admirably for Champions. S. Göransson on the other hand, had a terrible day. Grilled's top performer was clearly 田. 勇航 (Yonghang). However, G. Filippone made a disastrous appearance. The match ends 5 - 0. </s> Creating this painting was nothing but fun.</s> A programme to support families and challenge the behaviour of domestic abusers is to be expanded following a £360,000 cash injection.
"During this parliamentary year we are introducing legislation to create a new domestic abuse offence to ensure psychological abuse can be dealt with under the law as well as physical ab
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February 23, 2021 – .
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Anne-Claire Delisle has been drawing her whole life. After studying graphic design at university, she became an illustrator for books, magazines, and advertising. Today she also teaches illustration at Cégep de Sainte-Foy in Quebec City.
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99
Short url : http://fcbf.com/blog/1P/
FMC Grants NCBFAA Petition on NRAs and NSAs
Dec. 19, 2018, 1:49 p.m.
Aug. 21, 2018, 2:21 p.m.
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Vampire Academy Richelle Mead celebrates years of Vampire Academy with an exclusive never before The Turn and the Flame takes a deeper
Published :2019-04-15T04:58:10+00:00
14 Apr '13Future d [...], [...]
So many people talk about Twilight and miss this super great bookI liked Twilight, but I had a hard time dealing with Bella. I thought she was just toorly for some having with vampires. I wanted someone that could stand with them in a fight and not cower behind.Enter Rose. She is the bodyguard to Lissa, a vampire princess that must attend school and keep out of the clutches of the dark side. Rose is aggressive and hard headed, sometimes risking Lissa while trying to prove she is strong, but all [...]
I like this series because everything makes sense.Unlike other urban fantasy series featuring vampires. *cough* Twilight *cough* It’s an old subject, so I won’t dwell on it, but let’s just say that there’s nothing terrifying about having your vampire body sparkle like you’re covered with diamonds. It’s ridiculous.But this book isn’t. I find the concept of having vampires be protected by guardians very interesting. For once it’s the bad guys that need protecting—though they’re [...]
IThe before : September 2010I [...]
I Don't watch the movie it was painful.
(thedailybeast/blogs-an) .Be: these books are really readable and quite good fun. s. o [...]
V(meaning six years). e [...]
I finally decided to bite the bullet and pick this series up. I' It was SO REFRESHING Full review to come (maybe.)
4 Little run aways stars ******************Spoilers*********************I don't know what it is about teenage vampire love stories, but I eat them up like chocolate! I de Y(this was years a [...]
DNF @ 100 PagesBuddy Read with Melanie | | Belle | | Bethan | | Emmy | | AlyssaI tried.ets. ~~~~~~~~~~I've watched the movie a long time ago and thought it was shitty so I think it's about time I pick the book and see for myself if it's better than the movie!
Bs,the delightful Jess&the wondrous Kat (Her review is made of WIN!)!! Vampires! Vampires! Vampires! UNPOPULAR OPINION TIME!2.5 StarsSo, as you might have guessed by that star rating Vampire Academy was a miss for me. Not entirely a miss but a miss nonetheless. My Grievances:Girl-on-Girl Hate: I hate this shit so much and it’s everywhere in this novel!! Every time I turned a page I was slapped in the face with it! Mia hates Lissa,.Not that there's anything wrong with that.or whatever he is. n [...]
6 stars!t!!For two years, Rose Hathaway and Vasilisa [...]
I loved this book! I'm not into YA books, but I loved this one. Maybe it was because even though it was a YA book, I didn't remember it was about a girl of 17 until she said she was that age. The heroine in this book doesn't behave like a teen, and Dimitri for sure isn't. I can't wait to read more about them.If you read this book knowing that it is YA, you'll love it. I read other paranormal YA books, and didn't like them this much. It is better than the house of night series and the vampire dia [...] a [...]
I've made it my mission to finish this series once and for all, but three years can do a lot to one's goldfish-like memory- and so a re-read is in order!~Review: Over the past few months, I'd only ever heard good things about Vampire Academy and me putting it off for this long was only due to my bloody skills at procrastination.Richelle Mead, you've just bitch-slapped and walked over every other young adult vampire book out there in all your whip-smart, butt-kicking glory for me with this one! A [...]
TAll I can say is that I know someone who just made it into my book boyfriends list. This book was so much fun to reread. I had forgotten quite a bit! I can’t wait to jump right into the second one. I feel likeCan we talk about movie Dimitri? What the bloody hell is this ? This guy looks like a 40 year old creep to me. [...]
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Not everyone has an easy time staying afloat in this current economy. Bail can be extremely expensive, and unless you have piles of money lying around, you are probably going to need to use a bail agent to rescue your friend from jail. Using a bail agent to bail someone out of jail can greatly reduce the cost of the bail, especially if you use Bail Bond Store in Burbankat Bail Bond Store in Burbank of our bail agents and give him or her a little information on your loved oneAt Bail Bond Store in Burbank, we make bailing a friend out of jail easier, by making it more affordable for our clients. By using a bail agent to bail someone you care about out of jail, you automatically lower the cost of the bail by 90%. Say your friend’s bail is $10,000 by using a bail agent, you only have to pay $1,000 for the bail bond.
In addition, we are willing tThis way, it is even easier to pay for the bail bond because the large cost getf you have to bail a friend out of jail and you are on a budget, come to Bail Bond Store in Burbankbail agent from Bail Bond Store in Burbank about bailing out someone you care about.
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Rebels to dump O'Connor
Sydney -The Melbourne Rebels have compounded Wallaby flyhalf James O'Connor's woes at losing the deciding Test to the British and Irish Lions by confirming Sunday they will not be offering him a - club next seasonly--line performed with O'Connor calling the shots at number 10. O'Connor was one of Australia's better players in the third Test loss, scoring their only try after a superb jinking run.
"I've said I want to play 10 (fly-half) but I just want to be part of the team," O'Connor said.
"I'll play wherever I can. I would like to nut down a position, maybe 10, maybe somewhere else.
"I can look myself in the mirror and say I gave my best shot for Australia."
Read More On: melbourne rebels super 15 james o'connor rugby
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I didn't particularly watch PSE's development over the years, but the Stinger was always quite adjustable. They released a new bow named "Uprising" for this year, with 15..70 lbs and 14..30"....
Just asking as have never seen that much DW adjustment on a PSE before. Am more than happy with my Xpression, would just prefer to shoot it near it's peak weight and not right down the lower end of...
The Stinger (Stinger Extreme, to be exact). This bow is aimed at the entry level market, were draw weight and draw length adjustment is more of a topic. The beginner needs to find his technique...
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tact
Articles by Abdul Aziz A. Al-Askar
Abdul Aziz A. Al-Askar
Journal of Plant Protection Research 2012;52(4):458–462
DOI: https://doi.org/10.2478/v10045-012-0073-9
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But how do things look like from the perspective of Salesforce?
ExactTarget is a cloud-based digital marketing company with an impressive list of clients, from Coca-Cola (NYSE:KO) to Microsoft (NASDAQ:MSFT). They cover every aspect of online marketing:. Furthermore, they have a huge SaaS global services organization: more than 400 experienced marketing experts working around the clock. At first glance, this business looks very promising. Let us now move to the fundamentals. As for revenue growth, it is happening. But how about profitability?
Now, my concerns do not end here. As many of you know, Salesforce is committed to reach $1B in marketing cloud revenue over the next years, and to do so, they are relying heavily on acquisitions. In 2012 the company bought Radian6 for $336M. Radian6's only asset was its software to identify and analyze conversations about companies and products, by data mining social media platforms. Also in 2012, the company bought Buddy Media for more than $650M. Buddy Media is basically software to run integrated campaigns across Facebook, Youtube, Twitter and other sites. It helps companies to increase their fans and followers. Each of these companies may offer a different approach to cloud marketing, but in fact their services are very similar. And ExactTarget also offers tools for running marketing campaigns across Facebook and Twitter, amongst other sites!
Unfortunately, hackers will always try to hack the cloud because that is where all the data is going. Just like bank robbers will always try to rob banks!
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You can get some graphics (photo and shark-track) ONLINE.
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MT. MORRIS TOWNSHIP, Michigan — Several children were rehearsing for an upcoming dance performance when a naked man running from police came into the Macedonia Missionary Baptist Church, the chairman of the board of deacons said.
Only a few of the children actually saw the man, he said. Adult supervisors ushered the children into a different part of the church, he said.
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The key to managing time and cost in local United States domestic freight is efficiency. KRIEGER ...
If you have had goods stopped and turned away at customs, you will fully understand the costs and...
Norman Krieger is experienced at the collection and holding of merchandise at our bonded secure w...
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happier. </s> Kiri Te Kanawa's Favourite Mozart Arias
Dame Kiri Te Kanawa made her break through as a Mozart singer and went on to become a world-renowned Countess, Donna Elvira and Fiordiligi.
Kiri Te Kanawa discusses the Mozart arias that mean the most to her. </s> “Hey! It’s Gavin! Remember him? How about the other guys? Because, you HAVE seen them before…...34:Boy* do not let my possessions "own" me.
* work with person I've always admired.
* Master the Internet specially the technical side.
* spin a plate on a stick
* study culinary in France
* save a life
* swim with dolphins
* learn sign language
* have my own cake shop
* be careful what i wish for......
ks* </s> Doug and I got a lot done today. Cleaned up a brush area, planted potatoes and 25 Ft. Laramie Strawberries and enjoyed brats over a campfire for supper.
New row of red potatoes.
We had a little extra help with the garden this year.
Brats and a campfire to end the day.
It was a lot of fun working with you. The garden plan is really coming around, a nice change. </s> Daily Newsletter (18th June 2014)
Saturn is already running in exalted sign Libra.
Rahu shall enter in exalted sign Virgo on 15th July 2014.
After a long time period, this kind of planetary combination will be observed. May be, the same combination was seen a century back.
Jupiter’s transition to Cancer is very supportive for banking and financial sector.
On 29th, Mars shall enter in Chitra nakshatra.
Then onwards, a bull cycle will start in stock market, which would continue with volatility till November 2014.
You are advised to make long position in financial and banking stocks on 29th June 2014.
You are advised to make short position in S&P500 there.
In next week, S&P500 could drop to 1,905-1,890.
Bullion shall be overall positive till 23rd /24th June 2014.
Gold is expected to go up to 1,290-1,300 while Silver is expected to go up to 20.30-20.70. This shall happen in the mentioned time frame (till 23/24th June 2014). You are advised to long bullion on dips and book profit by 23rd at higher level.
Copper shall be in overall positive trend.
– COPPER:3.0450-3.08
Crude Oil is expected to cross $107.50/bbl any time.
It could even go up to $110/bbl.
– CRUDE: 105.90-107.20
– NG: 4.75-4.65
Maintain long position in EUR/USD.
-USD/INR(SPOT):60.40-60.00
-DOLLAR INDEX: 80.75-80.50
-US 10 YR T BOND: 2.68-2.59
Indian market shall be volatile till 13.30 HRS IST. And then onwards, a positive trend shall be seen, which would last till 15.00 HRS IST.
At closing hour, you can make short position in NIFTY with stop loss 7,770 for target 7,450-7,300.
You are advised to book profit in long positions in NIFTY & BANK NIFTY today.
The transition of Jupiter in Cancer is supportive for RELIANCE INDUSTRIES.
Important Notice: In next week, a sharp correction is expected in Indian market as well.
-NIFTY
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Ferraro ',' Sarah Palin wrote on Facebook.
congresswoman, and vice prThe world will miss her. May she rest in peace and m"
Speaking on Fox News, Palin recalled that she and Ferraro had discussed the possibility of a woman becoming president some day. “We were both excited about that,” Palin said.
Palin also said Ferraro "plowed through so many things that allowed the rest of us to progress," and that she "embraces the idea of the pioneering spirit the America is all about.”
"We disagreed on some aspects of our politics," she added, "but certainly agreed on the rights women have.”
"We will all miss her," Gingrich said. "She with a deep love for her family and for America."
Haley Barbour said that "although our politics were very different, I always considered Geraldine Ferraro a friend. She always worked for the public interest as she saw it and understood that you could disagree about politics and still be friends.”
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may test a price resistance at $1,847 an ounce. If the bullion moves above that level, it could climb to $1,876.
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'Old Bill' saw action in The Great War.
The London Transport Museum had humble origins when, in 1920, The London General Omnibus Company had an idea to preserve two Victorian horse buses and a motorbus for prosperity.
Housed within the Grade II listed Flower Market building. The buildings, which were vacated by the flower market, in 1974, were restored and refurbished, over a six year period, allowing the museum to open in 1980.
MillenniuM Dome
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Born on November 16, 1960 .
Passed away on December 2Rogers 52 years old , born on November 16, 1960 and passed away on December 29, 2012. We will remember him forever.
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"This gift reinforces The Phillips Collection's work in DEAI," says Chief Diversity Officer Makeba Clay, "and comes amid the social unrest occurring across the country in support of Black lives, and as museums are facing charges to address their exclusionary history and practices. This gift is a remarkable testament to the museum's vision to deeply enshrine DEAI values across the institution and it will propel the Phillips to become a leader in this evolving space."
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"I'v Even though I was diligent about implementing and trying different things Iluster results, so by the time I talked with Mikki Mikki weaves together an awesome combination of skills and resources that she's transformed into her own style, making it possible for her to effectively shift energy, create clarity around what soul driven purpose looks like, and bring visible changes to areas that felt totally blocked and stuck.
"Mikki, our conversation was a game changer.
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British director Joe Wright earned recognition for his creative adaptations of beloved literary works. Before crafting his award-winning debut feature Pride & Prejudice, he directed the short films Crocodile Snap and The End, and acclaimed series like Nature Boy and the 2003 BAFTA-winning Charles II: The Power & the Passion. His features include romantic dramas like the stylized Anna Karenina and Venice prize-winner Atonement, the action thriller Hanna, the 2015 Peter Pan origin story Pan, and the Winston Churchill WWII drama Darkest Hour.
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“With the retirement of two long-standing local doctors almost a year ago, some Derwent Valley residents are still waiting to get on the books with local GPs,” Ms White said.
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Asian food stores. they are small hard string noodle made from bean powder, do not to be confused with the rice counterpart.
Black Fungi: This can be found in Chinese or Vietnamese stores, they only come dried in packages. Also known as cloud ear fungus because they resemble ears protruding from tree trunks.
Half-Grained Rice: This can be substituted with medium grained rice, as long as the grains seem half of a normal jasmine grain </s> US flag with 80 stars by BF1395tom Atom (Russ: ) refers to an Alaskan economic energy initiative championed and instituted by former Premier Vladimir Putin in 2006 and 2007, in which the government made its goal to triple the number of nuclear energy plants in Alaska from 30 to 90 by 2025, at a cost of almost $200 billion (US). The initiative would also modernize many of Alaska's aging nuclear plants, including well-known Zagodrastaya, and provide seed money for companies willing to test thorium reactors. As of 2012, 17 permits have been processed for new power plants, and five of these plants have begun construction after early design. When the project is finished, an estimated 96% of Alaskan electricity and commercial power will be generated by nuclear power, allowing gas, coal and oil resources to be earmarked for export or industrial usage. While opposed by many anti-nuclear energy activists, it is regarded as one of the most ambitious sustainable energy projects in world history. </s> MetLife Alico rebrands to MetLife in the Gulf
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Applicationevant to your own essay subject. Pupils must notan person willmanner. Composing several essays could be simple too.n to on tv.
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I will update these pictures as the layout progresses. They will be in order going down from the top.
The first two show the initial layout bench-work and the third shows the staging yard. The staging yard is used to add additional trains or cars to the layout. It is like extra storage for cars that will not fit on the layout.
I am now about a month into the project. I have made some significant progress. The third level is now visible. And the second level where the yard will go has a base. Also the third level has its base where much of the industry will be located.
This is as of 6 April 2018. All track for level 1 is in place as well as the main line for level 2. I can now operate a train completely around level 2. I have one of the two access grades to level 3 with track (in the foreground) and the base for the other access is in the rear (just plywood at this point - no track yet).
These next two are of the staging yard which will be hidden from view once the scenery and backdrop are in place.
This is a couple of shots of the first train to go completely around the main line on level 2.
This is the round house and turntable area on level 2.
Return To Main Photo Menu
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Dr. Raymond Osarogiagbon Memphis, TN 0.01 </s> Quality Rating
April 1st, 2010Mixed
August 24th, </s> Canada’s forests contain many tree species. Grouping species according to genus makes it easier to see where trees of different types are dominant.
A silhouette is shown for one species of each genus, to represent that genus and provide an indication of the shape and size of trees found in different parts of CanadaYellow (CBL-CAT5E-CMP-YL) - Yellow
- Solid Copper, Yellow Jacket, Reelex IITM Box </s> CoSrdegar Blaenau_Gwent Wales.More Information >> </s> The biggest reason that red wine is kept in dark bottles is to avoid damage from light. Light is a form of radiation that moves in waves. Short wavelengths, such as ultraviolet (UV) light, are very high energy, whereas longer wavelengths, such as infrared light, are much lower energy. Visible light falls right in the middle, with wavelengths between 400 and 750 nanometers.
- Dimethyl sulphide (DMSP). Known as the “smell of the sea”, this is the metabolite given off by marine algae that gives ocean water that cabbage-y, fishy smell that is characteristic of marine environments.
These are certainly not things you want to see on wine tasting notes!
However, since red wines tend to be cellared longer, they are more likely to be exposed to light before they are consumed, so they need to be kept in darker bottles. Thus, red wines are usually kept in amber bottles and whites are often kept in green ones. </s> - Document custodian requirements for government loan modifications
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Christos Vourellis ( Greece )
Astrophysical jete. They appear in various different astrophysical objects (from protostars to active galactic nuclei) and are associated accretion disk around the central object and strong magnetic fields. The physical mechanisms behind the launching of the jets are not yet perfectly clear, however we know that magnetohydrodynamics are playing an important role. During the past years, different mechanisms were proposed which were combining general relativity with magnetohydrodynamics and were trying to explain the formation of the jets from an accretion disk.
Supervisor: Christian Fendt ( MPIA )
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Reality Steve Bachelorette JoJo Spoilers 2016: Who Does She Choose?
Fans of couldn’t have been more happy when Chris Harrison revealed that ABC had duped everyone into thinking Caila Quinn was going to be the next Bachelorette, when really it was fan favorite JoJo Fletcher.
Now that JoJo’s season has finally begun, fans can’t wait for her to wade through all of the men hoping to win her love and find the one she truly wants to be with. Of course, that is a long way down the road, and some fans just can’t wait! Luckily, trusty spoiler King, Reality Steve, has all the information needed for the entire season, right down to who JoJo chooses!
Reality Steve’s reports cannot be fully guaranteed until the season is over, but he has a very good track record so far, and was calling Lauren Bushnell as Ben Higgins’ winner long before the finale episode aired. In JoJo’s case it seems there is a lot of drama on her road to love this season, but she does succeed, reportedly falling hardest for Luke Pell, Jordan Rodgers, Chase McNary and Robby Hayes.
In the end however her final rose, and heart goes to early favorite Jordan Rodgers. It has only been one episode and Rodgers has already been tagged as a womanizer and using the show to bolster his own career, meaning fans are in for one crazy ride this season.
Get to know her final four and winner better here!
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para trabajar con la base de datos en configuración de inicio:
- `HMHome` -Éste es el contenedor de nivel superior que contiene toda la información y las configuraciones de todos los dispositivos de domótica en una ubicación física única (p. ej. una sola familia residencia). El usuario podría tener más de una residencia, como su casa principal y una casa de vacaciones. O es posible que tengan diferentes "contiene" en la misma propiedad, como la casa principal y una casa de invitado en el mercado de artículos. En cualquier caso, al menos una `HMHome` objeto _debe_ configurará y almacenan antes de que se puede especificar cualquier otra información de HomeKit.
- `HMRoom` -While opcional, un `HMRoom` permite al usuario definir salas específicas dentro de una casa (`HMHome`) como: cocina, baño, artículos o sala de estar. El usuario puede agruparespecífica dentro de su casa en un `HMRoom` y actuar como una unidad. Por ejemplo, pedir Siri para desactivar las luces de artículos.
- `HMAccessory` -Esto representa un usuario individual, HomeKit físico habilitado el dispositivo de automatización que se ha instalado en residencia del usuario (por ejemplo, un termostato inteligente). Cada `HMAccessory` se asigna a un `HMRoom`. Si el usuario no ha configurado los salones, HomeKit asigna accesorios en una sala predeterminada especial.
- `HMService` -Representa un servicio suministrado por un determinado `HMAccessory`, como el estado de encendido/apagado de una luz o su color (si se admite el cambio de color). Cada `HMAccessory` puede tener más de un servicio, como la apertura de la tapa de artículos que también incluye una luz. Además, un determinado `HMAccessory` podría tener servicios, como la actualización de firmware, que se encuentran fuera del control de usuario.
- `HMZone` : Permite al usuario que agrupa una colección de `HMRoom` objetos en zonas lógicas, como escaleras arriba, escaleras abajo o sótano. Aunque es opcional, esto permite interacciones como preguntarle Siri para todos los de la luz activar está desactivado.
## <a name="provisioning-a-homekit-app"></a>Aprovisionamiento de una aplicación HomeKit
Debido a los requisitos de seguridad impuestos por HomeKit, una aplicación de Xamarin.iOS que usa el marco de trabajo de HomeKit debe estar correctamente configurada en el Portal de desarrollador de Apple y en el archivo de proyecto Xamarin.iOS.
1. Inicie sesión en el [Portal para desarrolladores de Apple](http://developer.apple.com).
3. Si aún no lo ha hecho, haga clic en **identificadores** y crear un identificador para la aplicación (por ejemplo, `com.company.appname`), persona editar su identificador existente.
4. Asegúrese de que el **HomeKit** se ha comprobado el servicio para el Id. especificado:
[](homekit-images/provision01.png#lightbox)
4. Haga clic en **perfiles de aprovisionamiento** > **desarrollo** y crear un nuevo perfil de aprovisionamiento para la aplicación de desarrollo:
[](homekit-images/provision02.png#lightbox)
[](homekit-images/provision04.png#lightbox)
8. Por último, edite su **Entitlements.plist** de archivos y asegúrese de que el **HomeKit** derechos se ha seleccionado: r los derechos de su lugar, la aplicación ahora está lista para tener acceso a las API de Framework HomeKitvea nuestra [aprovisionamiento de la guías.
> Probar una aplicación HomeKit habilitado requiere un dispositivo iOS real que se ha aprovisionado correctamente para el desarrollo. No se pueden probar HomeKit desde el simulador de iOS.
# HomeKit accesorio
Para proporcionar una manera de probar todos los dispositivos posibles domótica y servicios, sin tener que definir un dispositivo físico, creado Apple el _HomeKit accesorio simulador_. C
### <a name="installing-the-simulator"></a>Instalar el simulador
Apple proporciona el simulador de accesodeberá iweb)
2. Descargue el **herramientas adicionales para Xcode xxx**garas de la **aplicaciones** directory.
Con el simulador de accesorio HomeKit instalado, se pueden crear accesorios virtuales para pruebas.
### <a name="creating-virtual-accessories"></a>Creación de accesorios virtuales
Para iniciar el simulador de accesoriote:
1. En la carpeta de aplicaciones, iniciar el simulador de accesorio HomeKit: HomeKit accesorio")en el **+** botón y seleccione **nuevo accesorio...** :
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How a Nomadic Couple Designed Hats to Inspire Your Next Adventure
September 6, 2017 By [email protected] Leave a Comment
Alex Knorr and Loz (Lauren) Williams are the founders of Will & Bear, an Australian handmade hat company that was inspired by the road and is designed to inspire others to adventure often.
The Hat That Travels
Both at a similar crossroads in their lives, Loz (Will) and Alex (Bear) met at the perfect time. They both loved to travel and it soon became the foundation of their relationship. They decided to pack their lives into a 1982 Kombi Transporter van to travel the coast of Australia.
“It’s a lot of work at times, but a very interesting way to live and lot’s of fun,” said Alex. “It is testing as well, but the majority of it is great. You find yourself in crazy spots and meeting some amazing people.”
On a summer trip, Alex was on the hunt for a new hat to shield him from the scorching sun. However, he surprisingly found few options, especially for men. He wanted to find a hat that he felt a connection to and one that would inspire him on his journey. Eventually, they found a hat at a second-hand store that had all the beautiful marks and notches of its past adventures. The hat began to embody the essence of their journey.
“Loz would always fight me for it” Alex said jokingly. “We just wanted to wear it when we were traveling, especially in the van. There’s a beautiful story behind these objects. It’s the hat that travels and gets out there.” Realizing there was something special behind this idea was the catalyst for Will & Bear.
Since they were in relatively uncharted territory, Loz and Alex set up an Instagram account called “Babes in hats” (@babesinhats) to test the brand concept. Alex admits that the name is somewhat ridiculous. However, the account became a hit and accumulated thousands of followers.
“It helped us build a community before we even started. I think that’s really important,” he said. “Our community is amazing; they share our story, we share their story. It’s grassroots and that’s the best thing about it. It feels so organic and just feels right when you’re doing it.”
Loz started her career in a more conventional finance job, but Alex had been a freelance designer for years. He started in product design and moved into branding, graphic design, and even dabbled in interior design. “It got weird, but I got a lot of exposure to some interesting projects and that helped when starting our own thing,” said Alex.
Alex’s freelance business was going well so they tried to put as much as they could into savings for Will & Bear while living off of Loz’s income. – primarily for the initial product run.
“What we found is that there’s no right way of doing any of this. There is no rule book. Looking back now you could probably simplify what we did as well. We had thousands of hats for our first run, but we were only selling about ten hats a month. There were some tough times where we said ‘shit this might not work’ and wondered if we just had a warehouse full of hats,” he laughs.
But soon, orders began to snowball. Will & Bear’s hats are now in about 100 boutique retailers and one large Australian online retailer called The Iconic.
It’s a Bit Theatrical
Leveraging Alex’s experience in design and Loz’s background in finance, they dug deep into learning the hat-making process. “It’s a really interesting process and actually quite complicated,” Alex said with an excitement in his voice. As a designer, he grew to love using wool in products. Not only does he love the tactile nature of it, but it’s a renewable sourey decided to use 100% Australian wool to make their hats.
The process is still predominantly done by hand. The raw wool, delivered straight from the shearing shed, is milled to remove any impurities and refined down to the best strands. Those strands are compacted into cone shapes, pressed, dyed, and formed. The molding machine presses it with heat and then steams it to put moisture back into the fibers. Finally, the sweat-band and leather features are sewn onto the hat. “It’s a bit theatrical in the factory with the heaps of steam and all the hand processes,” Alex said.
To ensure ethical sourcing, their hats are made in a certified fair-trade approved factory in Mongolia. Also, they
“We want to promote a more responsible and thoughtful way of doing business. Also, we celebrate the slow-fashion aspect of hats; we want them to last,” said Alex. “We’re not perfect, but as we grow we are getting better and better. Not only by finding the best factories and the right materials, but also moving towards recycled packaging. You have to make baby steps and as much as we’d like to do it all at once, there’s an economic side of this too because our business has to be sustainable. It’s something we believe in and I think being authentic is important.”
Setting The Foundation
You can’t help but feel a connection to the timeless, outdoor aesthetic that is the driving force behind Will & Bear. Their lifestyle branding will make you feel a sense of nostalgia for places you have never been. “I’ve found that it is so important to set the foundation,” said Alex. “Leading by example, especially in this field, is so important. It sets the standards for the company so people get an idea of what you’re about. It also helps draw in other talented people.” They now have a creative community of photographers and ambassadors to help tell Will & Bear’s story.
Alex acknowledges that there has been a huge learning curve for him and Loz. They structured the business in a way that allows them to travel and continue to do the front-end marketing th. Their success so far hasn’t come easily, but Alex believes that being uncomfortable is a necessary evil when pursuing your goals.
“It’s the way that you put aside the scary decisions and trust your gut,” said Alex. “You have to have a bit of blind optimism that it will all work out in the end. People are stuck in their day-to-day. Worrying about making their mortgage payments and the tasks in-front of them instead of looking at the big picture. I think the biggest lesson that living and working in a van has taught us is that if it all goes to shit, we still have the one thing that could save us. We would still be so happy to just live in the van and get by. Living simply has taught us that there really is nothing to lose.”
To find out more about Will & Bear (and buy a hat!), visit their website at willandbear.com or follow them on Instagram @willandbear. I hope you found inspiration in this story and if you did, please share. Comment below or email me at [email protected] to let me know what you think
Filed Under: Apparel, Interviews, Travel Tagged With: adventure, entrepreneur, handmade hat, travel, Will & Bear
« Friday Film: “Jim Carrey: I Needed Color”
Friday Edition Vol. 13 »
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May 29, 2007Nova Ren Suma3 Comments
I am writing this quick dispatch from my morning writing spot in the few stolen moments between paragraphs, a mere hour until I have to run in for a meeting at work. This is the coffee chain downtown that has seen me write truly hundreds of pages in the past couple of years (if you count the ghostwriting, and I will, because it sounds more dramatic). It hit me, upon coming in this morning and hearing them call out, “Iced or hot today, Nova?” that, after this week, I won’t be coming here in the mornings anymore. I won’t be sitting at this table, my favorite one near the little door that never opens. I won’t be one of the regulars—look, there’s another one now; we just shared a silent nod. This place isn’t convenient to my new commute; I will have to find somewhere else to go. And other places are louder, and do not have so many available outlets. (And the mochas are just not as good.)
I’m a bit choked up.
So, starting June 4, there will be an empty corner convenient to the 1 train. To the writer who takes my place: treat it well. Write a page for me.
Sometimes I get completely and totally obsessed with short stories—yes, the most impractical of fictions. Not just reading them (though put me in a room with a good selection of literary journals *ah, periodicals room at Butler Library, how I miss you* and you might have to drag me from it) but wanting to write them. Wanting to write so many! The ideas keep coming. I know I’m nothing in the face of those ideas, I will never get to all of them, I will probably forget most of them, but it doesn’t matter in these breathless moments. I just like thinking up their voices, their people, their tastes, their shapes. I will go to the website of a literary journal, read the excerpts, want a copy, think of slipping out to my most favorite bookstore in the universe to see what new issues they have in stock, wondering if they have in stock some of the journals my stories are in, wondering if I could possibly write more stories, just more and more stories to try to publish in these journals I love, and what if I did nothing else but write stories, like a story a week, is that possible? is that physically or mentally possible? I mean it takes me months to write just one story, months, and can I change that? can I do better? because I love them so much, I just, I, oh, and then, then, then I take a pause. A good long breath. I can hardly contain myself. Is this some kind of writer psychosis?
Many, very vivid moments would be included.
When I thought an editor at my company was going to want to publish my novel I imagined her arriving at my office unannounced, looking for me. (As if she’d leave her floor in the other building to come talk to me; how laughable now.) Still, I imagined how she’d tell me the news. I imagined my surprise. I hoped I wouldn’t be dressed too schlubby the day she arrived. I hoped I wouldn’t start crying.
My imagination just won’t die when it comes to these things. You think it would have learned its lesson. But no.
For instance, I really wanted to go to Bread Loaf this year, but I didn’t get a scholarship (and I said on the application not to consider me for regular paying admission without a scholarship). So I can’t go. Fact is, I am not going. This cannot be disputed. But maybe in my head I am going. Maybe I am there right now. The picture would be bright, soothing green, a thrilling blur of motion cascading over the page. In my head, before I got the news, it was quite an intense experience. When I was waitlisted for the waitership some years ago I had those same bright green images (though slinging plates in the cafeteria marred it somewhat), and I held onto them for the longest time, even after no one canceled and there was no space for me to go.
Then it occurred to me this morning, while checking blogs (yes, yes, I know I shouldn’t do that) before getting in the shower… I am only disappointed about that conference because I wanted something to look forward to this summer. I did get in to another conference: my top choice in fact. Though I didn’t get a scholarship there, at least they told me I was a finalist. And there is an open invitation to still go, if I could pay for it myself.
So you know what? In my fantasies, I am going there (IF I could somehow miraculously afford it, IF I could somehow miraculously get a week off from my new job just after starting)… All humongous IFs, but I’ll spend a little time pretending for the moment. It feels good.
It turns out my catalogue is coming together nicely. The title, the use of the word “disappointments,” might lead you to expect a certain thing, but it is the moment just before the disappointment that I want to remember. This one is bright blue, like the sky I picture on the West Coast. There are typed pages in my hands. There I am under that big blue sky, smiling.
I told you I was delusional.
p.s. I hope some of you reading are going to Bread Loaf this summer. Might you tell me if my fantasy is true?
But I Want to Be a Writer
May 26, 2007Nova Ren Suma9 Comments
But don’t you see, that’s the whole point! My writing should not be what I do on the side. It was never supposed to be a hobby. My job should be what I do on the side to have the means to keep writing.
May 21, 2007Nova Ren Suma5 Comments
It was an odd weekend. I napped twice in the span of three days. I do not nap; it’s something I try to avoid at all costs, all thoughts of napping forbidden! (Though, I’ll admit, I think longingly of leisurely afternoons spent napping more often than I should.) If I do nap, if I cannot keep up my defenses and I go down, I wake up a monster. I despise my weakness, I lament my lost time, I am worse for the wear. But sometimes, sometimes, I cannot help myself…
The first nap, circa Friday late afternoon, was expected. I was exhausted from the graduation trip and had hardly slept the previous two nights. This nap occurred on the couch, with the lights on, so you could say I was not fully committed to the nap itself. I was waiting for someone to say, “Are you napping?” at which I would shoot up and deny it. When I woke up, maybe an hour or so later, I shook it off and pretended it never happened. The first nap was a little hiccup in my otherwise motivated weekend existence. No one would know any better.
Saturday the writing project found itself completed a day ahead of schedule, which meant I had all of Sunday, an entire day!, for my own writing, for anything at all that I wanted, a day, a whole day. I was ecstatic. I couldn’t decide what to work on. On Sunday I woke late—another hiccup, but I ignored it—I spent an hour reading at the coffee shop, and then I went to my weekend writing spot.
…Where I got progressively more and more tired, until, come 4:30 in the afternoon, I found myself at home, in the loft bed, out cold. The nap itself was light. I was aware that I was napping, I was angry at myself for napping, but then this faded, the awareness, the anger, and I was just gliding through a faint sleep, not feeling much of anything. I woke from this nap easily, feeling—what is the word?—refreshed.
I’m not saying that napping will become a regular part of my weekend. I don’t want a nap habit. But if I’m tired next Sunday, you might just find my head down for an hour, maybe two. If anyone asks me outright if I’m napping I will obviously deny it—but you and I will know the truth.
May 20, 2007May 20, 2007Nova Ren Suma5 Comments
I attended my little sister’s college graduation this week—two separate ceremonies at a large urban university. She surprised us, and herself, by graduating with honors in her major, and magna cum laude. She had no idea, in fact, until we saw the symbols next to her name in the commencement program and texted the news to her, where she was outside on the street lining up in her cap and gown. She texted back to me: No way! Then she sent another text: Magna? How? I don’t think she believed it until she saw it on her diploma later that afternoon.
This is a girl who struggled through an intensely difficult year, too personal for me to recount here, who worked full-time doing long shifts as a waitress all throughout school to pay her own expenses. She did this on her own. She worked for it; she was never handed anything. She gets stronger and stronger each year. I am amazed by her. I remember the exact moment she was born—vividly; graphically. I love the person she’s become.
At the first ceremony, we sat in the stands and I saw the speck of her—a tiny dot—far away in her row. I was so proud of her, just filled with love for her, so happy, that the tears started threatening to come. I couldn’t stop them and was annoyed at myself when my teariness happened to coincide with the National Anthem. The photographs of me after this ceremony show a huge smile, my cheeks an astounding pink.
At the second ceremony, featuring her school only, there were still rows and rows (and rows and rows) of students, and we waited at least an hour to hear her name called and see her take her walk across the stage. I barely remember the moment. I know I stood up. I knew we cheered as loudly as we could. I tried to take a photograph, but I was so excited, and we were so far up in the stands, the image is a blur.
All the commencement speeches, so inspirational, reminded me of graduating college—how much I’d loved being in school, loved taking classes, and when it was over how the entire world seemed to be at my fingertips. I was heading straight to grad school in New York City. First, I’d spend the summer in Woodstock working at a jewelry store on the Green (ironically having to remove my nose ring in order to do so), then, after three months, I’d move to my Manhattan apartment. Six months later, I got couples housing and E joined me. I had the most enormous of expectations. Now, while it is true that I don’t remember too much of my own graduation ceremony, as both E and I had gotten quite drunk the night before so someone had to escort, i.e., practically carry, us back to our room (thank you, A) and another someone helped us up in the morning (thank you, P and others), I was taken right back there. We went to a small, odd school that didn’t have caps and gowns. I wore a blue shirt and a black skirt, my favorite colors. We didn’t have grades so I have no idea if I would have had any kind of cum laude tacked on to my name. I don’t recall who the commencement speaker was, though I do remember the same kind of message: You are graduates of [Insert School Here]. You can do anything. Now go out and make the world a better place.
I can’t say I’ve done that. I always meant to—but is it possible to do so as a writer, an artist? I certainly hope so, because that’s what I have to give. I haven’t made it yet, all these years and not yet, but I’m still trying.
Guest Post: Stories That Scare Dia Reeves
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Ways into the city's literature …
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Sunday, February 27, 2022: Set up begins at 1p.m. and you can showcase until 6 p.m.
Monday, February 28, 2022: 7 a.m. to 5 p.m.
Tuesday, March 1, 2022: 7 a.m. to 5 p.m.
Vendors covered under the Gold, Platinum, and Diamond Conference Sponsorships will be issued table/booth space based on sponsorship level.
Hotel (lodging) is not included in this packagingeir own lodging.
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February Calendar Page and January Giveaway Winner
Today I am announcing the winner of the Giveaway where anybody could enter by commenting on the January calendar post on this blog. I’ve also got the page I’ve decorated for February in my Mother’s calendar to show you.
The winner is Karin van Eijk (Karin, like me, is a crafting blogger. You can see her blog here –).
If you are not already aware – for a few years now I have been buying my mother a blank Papermill Direct calendar every year, and as the year progresses I’ve been decorating the pages in a variety of different ways. (You can see the January one – Here!) Sometimes she askes for something specific and sometimes she tells me to surprise her.
Both backgrounds are from the Fancy Fretwork USB that has lots of SVG cutting files and .jpg background designs. They were printed onto good quality, 120gsm paper.
The purple cardstock that’s framing behind the background, as well as the purple flowers and pearls used to decorate, are from the Hobby House Colour Collection – Periwinkle. The rest of the flowers and leaves are from my stash – Every now and then, when I have odd bits of cardstock, I either lay them on the cutting mat of my ScanNCut and set it to cut lots of different flowers or leaves depending on the colour, or I put them through a die-cutting machine with various sized floral dies. I keep all the flowers and leaves produced in a box to pull out when I need a quick flower on something.
Here’s the work before it was stuck on the calendar.
It’s a beautiful page Gwyneth and will certainly brighten up the dull days we are likely to get this month x
beautiful Gwyneth
and I hope you got my mail back with my address…………….and a big thank you again for the gorgeous prize…….
Hi Gwyneth this is a stunning calendar page you have created. I bet your mum was thrilled. Take care., Hugs Jackie
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Affililated Scientists
Outreach & Advocacy Calendar
Outreach and Advocacy Committee
Susan Perlman, PhD
[email protected]
PhD, Duke University (2009)
Neurodevelopment of cognition and emotion in young children
My multi-modal research program bridges the fields of social and cognitive development to form a field known as Developmental Cognitive Neuroscience. I employ multiple methodolpsychophysiological measures, eye tracking, and other behavioral and questionnaire measures to conduct cognitive and neural analyses of mechanisms underlying the development of emotion and its effects on social interactions. My investigations are grounded in the neurodevelopment of normative children with branches of my research program applying normative findings to atypically developing populations, including maltreated children, post-mood disorders, and, most recently, children presenting with high irritability. Specifically, my research interests lean towards the study of emotion regulation, best defined as the ability to manage positive or negative arousal so that the individual can successfully function on an interpersonal level. By studying the typical and atypical ontogeny of multiple aspects of emotion from relatively simple and early developing abilities (e.g., producing emotional facial expressions) to more complex and later forming abilities (e.g., perception and attribution of the emotional behaviors of others) at multiple levels of analysis, I aim to emotional systems.
Perlman, S.B., Luna, B., Hein, T.C., & Huppert, T.J. (2014). NeuroImage, 85(1), 326-334. (PMC3796135)
Perlman, S.B., Hein, T.C., Stepp, S.D., & The LAMS Consortium (2014). Emotional reactivity and its impact on neural circuitry for attention-emotion interaction in8, 100-109.
Perlman, S.B. (2012). Neuroimaging in Child Clinical Populations: Considerations for a Successful Research 1232-1235. (PMC3652337)
Perlman, S.B., & Pelphrey, K.A 7-620. (PMC3029468)
Perlman, S.B., Morris, J.P., Vander Wyk, B.C., Green, S.R., Doyle, J.L., & Pelphrey, K.A. (2009). Individual differences in personality shape how people look at faces. PLoS ONE, 4(6), e5952. (PMC2695783)
[email protected]
A206 Langley Hall
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The Orthodox Theological Society in America held its annual meeting on our campus from Thursday, October 18, until Saturday, October 20. The theme for this year's gathering was "Liturgy and the Arts."
The Thursday afternoon session featured presentations on "Perceiving Beauty: Architecture, Drama, and Philosophy." The evening's faculty panel was moderated by Rev. Dr. Philip Zymaris, Assistant Professor of Liturgics at Holy Cross, and focused on the question of "What is the place, and what is the function, of Sacred Arts in an Orthodox Theological School?" Friday morning sessions addressed "Approaches to Liturgy and the Arts" and "Women and the Diaconate." Two of the presenters at the latter session, Dr. Teva Regule and Dr. Valerie Karras, are graduates of Holy Cross. The afternoon program began with an exploration of "Marriage, Childbirth, and Liturgy" and continued with a panel discussion of, a new book by the theologian Dr. Vigen Guroian. Participating in the panel was Dn. Perry Hamalis, a Holy Cross graduate. The annual Florovsky Lecture was delivered that evening by Dr. David Bentley Hart, whose theme was "Beauty and Judgment." The final session on Saturday morning considered "Liturgy, Worship, and Questions for Today."
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By Kati Pearson (Director of Teaching and Learning) and Hana Insanally, Julie Staton, & Bianca Williams (School Improvement Program Specialists),Lake County Schools, Florida
Posted in blog, Common Core, Educator Voices, General, K-5, Leadership, Map Examples, Spotlight School, Uncategorized
My Year Without Target (And Other New Year’s Resolutions)
Last summer I made a very tough decision to live life without Target. Yes, Target! The store with the Red Bullseye logo. I did this for a number of reasons (many of which are unimportant) but what is important, is…
Growing the Creative Executive Brain
#5 in a series from The Motivated Brain: Improving Student Attention, Engagement, and Perseverance by Gayle Gregory and Martha Kaufeldt How many times have you heard, or even said, “My students can’t do that!” I remember when the graduation…
Posted on 29 November by Leanna Brown — No Comments ↓
Educators across the country are discussing “Rigor” and how to incorporate it into their classroom instruction: “Our lessons must be more rigorous.” “We must increase the rigor of our assessments.” “Does this book possess the necessary rigor for that…
Tagged with: classroom, educators, instruction, multiple maps, rigor, the navigator, Thinking Maps, TMLC
Posted in blog, Educator Voices, General, Leadership, Uncategorized
Does Your Brain Want to Learn? 5 Strategies to Promote Active Processing
Posted on 01 November by Carol Lloyd — No Comments ↓
#4 in a series from The Motivated Brain: Improving Student Attention, Engagement, and Perseverance by Gayle Gregory and Martha Kaufeldt So far in this series we’ve talked about the importance of stimulating the SEEKING system of the brain through…
Tagged with: ascd, brain, brain research, environment, gregory, kaufeldt, learn, Martha Kaufeldt, processing, students
Posted in Educator Voices, General, Leadership, Uncategorized
Tagged with: augmented reality, education, education fads, future technology, gaming, learning, motivation, navigator, pokemon go, students, technology
Posted in blog, Educator Voices, learning_subject, Technology, TMLC, Uncategorized
#3 in a series from The Motivated Brain: Improving Student Attention, Engagement, and Perseverance by Gayle Gregory and Martha Kaufeldt Okay, I am not a neuroscientist, so some of the information in this book is more technical than I really care about,…
Posted in blog, Educator Voices, General, K-5, Uncategorized
A Lifesaver for Educators Drowning in Initiatives
Posted on 22 June by Kevin Dougherty — 1 Comment ↓
As I travel to schools and districts throughout the country, one of the greatest challenges about which I hear educators complain is the overwhelming number of initiatives. When asked to elaborate, these educators indicate there is simply not enough time…
Assessment, Evaluation and High Stakes Testing
Posted on 13 June by Kisha Daniels, Ed. D — No Comments ↓
Well fellow educators, it appears that it is that time again. You know it is coming, but every year it seems to sneak up on us a little earlier. Much like seeing Christmas decorations pop up on shelves before…
Posted in blog, Common Core, Educator Voices, General, Map Examples, TMLC, Uncategorized
Finding Your Best Route to Thinking Maps
Posted on 04 May by James Dean — 5 Comments ↓
Many journeys begin with a map. This tool guides the direction we take to keep us focused on the course and, often times, the shortest or most desirable route to a destination. We refer to that map and current location,…
Tagged with: common visual language, course, detour, education, goals, initiative, journey, Leadership, Peace River, student achievement, ThinkingMaps
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The homeless in Fresno are under attack. This is the latest in a series of reports about the treatment of the homeless in this community.
When I arrived, Will was talking to Liza Apper, who works with the St Benedict Catholic Worker project http://www.sbcw.org/ . Liza and her husband Bryan were there to observe this attack on the homeless and try to provide some protection. While Bryan talked to the agencies involved about the law, Liza positioned herself in front of a tent that had been targeted for destruction. The owners of the tent were away when the bulldozer arrived and Liza was the only thing between the tent and certain destruction. She was told to move but held her ground. Eventually the bulldozer operator decided to go around Liza and moved further down the strip of land to scoop up blankets, food, and other items that had been left behind. About 30 minutes later, the owners of the tent returned. They hurriedly took their tent down and moved across the street.
http://www.indybay.org/news/2006/05/1822825.php
http://sfbay.indymedia.org/news/2004/02/1669522.php
These homeless leave. All photos by Mike Rhodes
§After the attack
Thu, May 25, 2006 11:11PM
Thu, May 25, 2006 4:26PM
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Search Garden Club honors Vaughn for years of leadership
Posted: Wednesday, June 18, 2008 Although the Watkinsville Garden Club was founded some three decades before Ellen Vaughn became a member, there's little question that her fingerprints are all over the organization's modern-day achievements.
Set to celebrate her 90th birthday in August, Vaughn was honored by her brothers and sisters of the soil at the garden club's June meeting, held at the home of Jackie Williams. The club further saluted Vaughn by planting an Oglethorpe oak tree on the grounds of Union Christian Church off Hog Mountain Road.
"The club wanted to honor Ellen because she's done so much," said club historian Lois Kraeling. "She's given so much to the club and to the community."
Kraeling said her husband, Bob Kraeling, compiled a list of Vaughn's accomplishments and created a special PowerPoint presentation on Vaughn for the meeting, which was attended by garden club members, as well as Vaughn's family and friends from Union Christian Church.
"She always kept the club going," added McCorkle, who lives in Bogart. "That's why we wanted to honor her. She's in a wheelchair these days, but she's still very alert and she's still telling us what we need to do. She's been a pillar of the community."
Vaughn, who has been plagued with back, hip and wrist problems in recent months, is recovering from a recent injury at the Family Life Enrichment Center near North High Shoals. She graduated from Madison County's Carlton High School in 1936 and by 1942 during World War II. She also served as.
After the war, Vaughn moved to Kansas City, Mo., and began working for Eastern Air Lines and moved to Atlanta in 1949. She retired from the airline in 1959, married and moved to Oconee County. On her 80th birthday in 1998, she was honored as a lifetime member of the Georgia Garden Club and served her final two-year term as club president in 2002.
"Ellen has led a very interesting life," Kraelingshe has accomplished. Shirley was looking through my history notes and said, 'It seemed like whenever anything was getting done, Ellen was at the forefront.' We had planned to recognize her at our March meeting, but she had taken a fall, so we wanted to do it as soon as possible because our June meeting was the last one of the year," she said.
The Watkinsville Garden Club was chartered and incorporated in 1941 and has done much in the way of community service, with the maintenance and upkeep of the Watkinsville Cemetery on Simonton Bridge Road one of the group's many beautification projects.
The 52-member club, which includes a half-dozen men in its ranks, also has beautification projects at the Elder Covered Bridge, Harris Shoals Park, the Oconee County Library (which has a "mini-garden center" devoted to the garden club) and the High Shoals Post Office. Club members also recently revived the Watkinsville Junior Garden Club, which includes about a dozen third- and fourth-grade students.
The clubmore information on the Watkinsville Garden Club, call McCorkle at (706) 549-4362.
KANSAS CITY CADILLAC MOTORS WATKINSVILLE CEMETERY MCCORKLE FAMILY LIFE ENRICHMENT CENTER WATKINSVILLE JUNIOR GARDEN CLUB MADISON COUNTY'S CARLTON HIGH SCHOOL WATKINSVILLE AIRLINE (706) 549-4362 ELDER COVERED BRIDGE ELLEN VAUGHN EASTERN AIR LINES OCONEE COUNTY FAMILY LIFE ENRICHMENT CENTER VOLUNTEER EMERGENCY SERVICE BOGART BOLT INSPECTOR ATLANTA JACKIE WILLIAMS Trending this week:
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IIFAC Store
A compendium of useful information, organized into categories, written by working experts in the field so that that you can find the help you need to plan and facilitate meaningful group processes.
Presentation of The Bonfire Collection in Tepoztlán, Morelos, Mexico (spanish)
Carlos Mota speaks about The Bonfire Collection
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We believe there’s any other factors that make up the diverse student body which we seek to represent.
We look to advocate for students by implementing a Judicial Branch of SGA. This branch would be made up of official student representatives, serving on disciplinary committees to ensure that students have peer representation for appeals.
Campus must be accessible to students to enhance the college experience; this includes access to programs and resources, promotion of fine arts events, as well as implementation of more disability services such as wheelchair ramps or elevators. Everyone deserves not only equal, but efficient access to all parts of campus.
And finally, affordability. Affordability impacts everything: from Greek Life and athletic recruitment numbers, textbook access, graduation percentages, and of course our ultimate goal, increased retention. We aim to listen to students’ concerns and take action by working with the entire USD community to arrive at a solution.
In these ways, our campaign introduces new ideas while also reforming the pre-existing foundations available on campus. Ultimately, we want to reach every student: we’re pushing for the highest voter turnout possible, using the hashtag #YotesVote.
We’re asking you, the student body, to use your voice and understand the action plans and dynamics of each candidate’s platform. With our history of sponsorship and support of several bills on senate, ourour diversity in majors, we ask to represent you and look forward to advocating for USD.
Vote for the A-team: Vote BRUST WEIGHTMAN.
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Family of Tom Niland - in ICU since a burglary at his home in January - give update on his recovery: "A tear fell from his eye"
Tom Niland (73) was left in a critical state after the incident at his home in Skreen, Co Sligo on January 18 - and despite some small signs of recovery along the way, he remains in ICU, unable to move or speak.
Now his cousin Michael, who visits him in hospital almost every day, says he fears Tom’s recovery could take years - if he even recovers at all.
When I go in and start talking to him, sometimes he looks at me but generally he’s staring into space.
Michael says he feels that if Tom is aware of what’s going on then he seems to be “depressed” and says he even shed a tear when he spoke to him the other day.
“Because you know he realises people are coming in and out and he’s stuck there in the bed and he can’t move.
Michael says efforts have been made to try and allow Tom to be able to speak again - but he feels they are a long way from that happening.
“So he couldn’t really talk but he might be able to whisper,” he said.
Michael says Christmas this year will be incredibly difficult for the family, who were so close to Tom, who lived alone.
“But nobody can really enjoy it because we have in the background this major loss.
“You wouldn’t feel right either enjoying it,” he said. And he said he can’t believe it is now approaching almost a year since the incident that led to Tom being hospitalised.
“It’s been since the 18th of January when it happened. We are approaching that now. Almost a year. It will be a lot more than a year before there’s anything significant, if anything at all.
“This time last year was a different time. It affects everybody you know. He’s survived this long so we don’t really know what’s in store.
“And the more he begins to realise what’s happened it will be very hard. I’m not even sure he has much of a concept of time.
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If you are allergic to Cytoxan (cyclophosphamide injection); any part of Cytoxan (cyclophosphamxan (cyclophosphamidexan (cyclophosphamidetoxan (cyclophosphamidCytoxan (cyclophosphamide injectionCytoxan (cyclophosphamide injectionCytoxan (cyclophosphamide injection). Talk with the doctor.
Some people have had lung problems with Cytoxan (cyclophosphamide injectionIf you are 65 or older, use Cytoxan (cyclophosphamide i Cytoxan (cyclophosphamide injection). Cytoxan (cyclophosphamide injectionCytoxan (cyclophosphamide taking Cytoxan (cyclophosphamide injection)t at night unless told to do so by your doctor.
Very bad and sometimes deadly urinary tract problems like hemorrhagic cystitis or pain when need to store Cytoxan (cyclophosphamidtoxan (cyclophosphamid.
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Lady appears on the streets wearing a statement necklace, off-shoulder pullover, grey bootcut jeans and purple pumps.
Continue reading Women’s Sporty Jackets →
How To Wear A Suede Jacket
Boho Chic Inspiration Ideas
Continue reading Boho Chic Inspiration Ideas →
Bohemian StyleBoho ChicFestival FashionHippie Outfits
This time fashiontasty is here to share with you cool bags and summer outfit ideas to try this year. You are about to see amazing looks to try from Mondays to Sundays, from work to special occasions. I think it’s time to enjoy the sun, as we see already feel the rising of temps and cloudless sky. All we need is to choose pieces that can be easily mixed and matched with each other, as well as worn from work to play.
15 Ways To Wear A Printed Blazer
We see a tweed white-yellow checkered tweed blazer worn with LBD, patterned black tights and cuffed glossy black pumps. In love with big sunnies, thin necklace, black-white miniature handbag and this pussy-bow.
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Dani (Leventhal) Restack (Studio Internship '97, Artist's Book Residency '07) and Sheilah ReStack were selected for the UNDO Fellowship, an initiative to expand radical filmmaking practices and research new languages of documentary cinema. The fellowship will culminate in a two-day symposium in Fall 2020, so stay tuned for information about that. Congratulations!
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The National Weather Service has issued an elevated threat of flash flooding through 7 p.m. Thursday, with 1-2 inches of rain in less than three hours possible over already saturated ground. Localized flash flooding is possible, particularly in low-lying and urban areas, and minor river flooding is also possible.
The threat drops to “limited” Friday, from 7 a.m. until 7 p.m., as heavy downpours could bring another 1-2 inches of rain.
Heavy rains and flash floods drenched Mississippi Wednesday, prompting rescue operations, closures and evacuations including dozens of residents at a nursing home in the central part of the state.
Rain has pummeled the central and southern parts of the state for the last three days. In statements posted to Twitter, the National Weather Service said flash flood warnings were in effect for several areas from Jackson, the state capital, to Meridian and southward to Laurel and Prentiss, with numerous reports of flooding Wednesday.
There have also been several car crashes reported, many due to hydroplaning, according to WAPT-TV. A Jackson man told the news station he became stranded after his car stalled on a flooded street. He said he did not realize the road he was driving on was flooded until it was too late. He sat atop his car and waited until first responders arrived.
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PET-happy.comTips to Improve Your Pet's Behavior, Health and Life...Home
You are here: Home / Cats / Cat History / What are the closest relatives to domestic cats?What are the closest relatives to domestic cats?
November 16, 2016 by Signe & Maris
At the same time, biologists agree that defining species is a tricky task. Under the general definition of species, domestic cats would belong to the wildcat species, sincBut, mainly because of their relationship with humans, they are still regarded as a distinct species. However, regardless of the definition, it does not really change who Felis catus, the domestic cat, actually is–a very close relative to the African and European wildcat.
Leopard cat – the closest relative to all Felis. Photo by Kuribo, CC BY-SA 3.0
See this too:What would a cat eat in the wild?How Fast Can a Domestic Cat Run?Why Cats Were Domesticated?Can a cat become vegetarian?
About Signe & MarisThere are two of us behind this website: Maris, who is ar. Learn more about us here.
Share Your Comments & Feedback Cancel reply NOTE: Considering our busy schedules and the uncertain nature of answering medical and behavioral questions without seeing the animal, we do not answer questions in the comments.Comment Name * Email * Website Join our newsletter and get our e-brook for freix reasons to take a healthy cat on veterinarian visits15
Constant Meowing
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James Bond conquers weekend box office with Spectre
James Bond racin Spectre, the latest installment in the spy franchise starring Daniel Craig, earning an estimated $73 million. Although it didn’t top previous Bond film Skyfall‘s opening weekend take of $88.3 million in 2012, it was nevertheless a great debut for the film, and it’s already the eighth highest-grossing Bond film domestically. You can read our review of this film b.9 stars.
Goosebumps also dropped two spots – from second place to fourth. The comedy for young audiences earned an additional $7 million in its fourth weekend and has a strong Tribute.ca 4.4 star rating.
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The most disappointing thing about the website is the lacku simply cannot find this information anywhere!
We were happy to learn that Essay-Company offers deadlines of even 20 days, but this does not really apply to papers such as essays, doesn't it?
"Not really the best service, at least not to me!My paper was not that bad, but their dissertation writer did not bother to proofread it, that's for sure. It had more mistakes than I could count, and I spent hours revising it since it is a hundred-page paper. I cannot believe I spent this much money on a company without a customer service!"
"Don't use essay-company!They are scam and overcharge you. I didn't notice they automatically add some extra features to the order, so I did not un-check these fields. I ended up paying double the price, and still got a bad paper. If this was their 'top writers' paper, I really want to know what their regular writers offer!"
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We visited Swiftcurrent Lake today. The last time I was at Many Glacier, thirteen years ago, forest fires were raging around the park and the sky was filled with smoke. It was hard to make out details on the mountains around the lake. Today the sky was clear and the sun shining.
Looking west from just outside the eastern side of Glacier National Park near Saint Mary. The weather was grim and dark, just the way I like it when I braved the rain to snap the frames that went into this panorama. I built this panorama directly from Nikon NEF files in the Windows version of Affinity Photo. My favorite image processor, Picture Window Pro, is being retired and I am exploring alternatives. I rather like this result.
Overlooking the grounds of Fort Missoula from a forest fire lookout. The remains of the fort have been turned into a small museum. The best exhibit in the museum was a collection of old postcards. Apparently collecting postcards is the third most popular form of collecting after stamps and coins. The best exhibit on the grounds was a logging camp library car. The white rail car in the middle of the picture was a rolling library. It was dragged from logging camp to logging camp back in the 1920s. Literate loggers: not exactly the standard backwoods hick cliché.
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Solheim Cup captain Suzann Pettersen defends Tiger Woods' tampon stunt
Tiger Woods got some backing on Tuesday from two-time LPGA major winner and Solheim Cup captain Suzann Pettersen when asked about his controversial tampon stunt at the Genesis Invitational.
Woods received backlash after cameras caught him handing a tampon to playing partner Justin Thomas after out-driving him.
The 15-time major champion apologised when asked about the motive behind the joke, saying he did not intend to cause offence.
"'m sorry," he said. "It was not intended to be that way.
"It was just – we play pranks on one another all the time, and virally, I different."
Speaking to the media after being named the European Solheim Cup captain for the next two editions of the event, Pettersen said she knows Woods, and believes his "boyish" humour had no malice.
"I know Tiger quite well," she said. "I don't know Justin Thomas as well, but I know kind of Tiger's humour, and that's a very probably boyish joke between the two of them and I don't really take it too personal.
"I think that was supposed to be a gag between the two of them and unfortunately some cameras caught it in the heat of the moment. I don't know, I don't think he meant to be offensive in any way.
"I'm pretty easy on stuff like that. I'm sure it was meant as a joke, not as a harassment to women in general."
Pettersen's vice-captain, Dame Laura Davies, acknowledged that the joke was sexist, but said "it's just banter on a golf course".
"I think it's misplaced jokes, a laddy kind of joke," she said. "Maybe he misread the situation – I personally am not offended by it.
"People seem to be looking for things to worry about. It's a shame it happened. We are talking about this rather than them entertaining thousands of people – I'm sure Tiger meant no harm by it.
"I can't believe there was any malice in it. It was really poorly judged, I am sure he would regret he did it now. He will be disappointed that he has been shown to be a bit sexist with what he did.
"It's just a bit of fun, it's just banter on a golf course. When Tiger does it, unfortunately, everything gets magnified."
Manchester United takeover news: Sir Jim Ratcliffe breaks silence after Old Trafford visit
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Gladys Knight Gladys Knight & The Pips
My daughter loves singing above all else.
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First Alliance Credit Union andas a part of IMAA’s Whole Family Systems Grant. The Whole Family Systems g.
The goal for the Broadband Community Access fund is to actively seek community partners to contribute to the fund to make it sustainable for years to come.
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We started Air Charter Advisors in 2012, and we have built relationships with clients, operators, and service providers around the world to offer the highest levels of safety and service possible. Our're located – we cover the entire globe!
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’t assist us in this manner, and nor was it designed to.
So if we really want to find what students know, let’s move more of our course work to competency-based educational units. Then we know if Johnny can spell, add, and think. We won’t have a number: we’ll have solid evidence. Perhaps “badges” aren’t a bad idea. Just like I can evaluate a Boy Scout by the badges sewed to his uniform, I can do the same with a graduate (sans the uniform, of course).
Of course, we wouldn’t think of doing that, and we shouldn’t think of doing the CLA+, because there comes a time when that type of testing becomes not only irrelevant but an anachronism—out of time; out of place. With the eclipsing of a personal era of learning and development, we gain other attributes and knowledge that supercede our prior learning. The same type of test does not measure this new learning. It will not measure how worthwhile someone is, nor does it measure their efficacy or motivation. It simply shows that they can complete—and pay for—another standardized measure.
*See Table 2 in: Klein, S., Benjamin, R., Shavelson, R., Bolus, R. (2007). The Collegiate Learning Assessment: Facts and Fantasies. Evaluation Review. 31 (5), 415-439. Sage Publications. </s> TA“Jun 21, 2018. How to best treat the annoying affliction known as post-nasal drip?. GERD involves the backup of stomach contents and acid into the.
Jul 5, 2018. Multivariate analysis showed that nasal discharge was associated with more cough, and GERD and postnasal drip were associated with mor
** How Long Does Acid Reflux Episode Last ** Can Post Nasal Drip Cause A Cough Untreated Acid Reflux How Long Does Acid Reflux Episode Last What Is The Reason For Heartburn with Turmeric Vs Tumeric and Pain In Chest Like Something StucHow Long Does Acid Reflux Episode Last. – ost-nasal drip is problematic for some. Ohio ENT & Allergy be aggravated by.
Jun 7, 2018. Most people have heard of acid reflux, or gastroesophageal reflux, also known as GERD. Did you know there is another type of reflux, knownd
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Posted on 12/25/2001 4:08:58 PM PST by CrossCheck
You folks just aren't serious. 19 people with some cause they were willing to die for but which is of absolutely no rational interest to 90% of Americans killed over 3,000 civilians in the US and caused $100 billion of damage. All we can do is retaliate by bombing "terrorist training camps" that are nothing more than desert and a few tires. Where is that going?.
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Next: Deducing Back-Facing SURFACEs Up: Hypothesis Construction Previous: Network Based Geometric Reasoning
In three dimensional scenes, not all object features will be visible (e.g. some will be on the back side of an object), and a true three dimensional scene understanding program should account for this. There are three distinct cases of feature invisibility. The first case always occurs: there are features on the back side of every object and these cannot ordinarily be detected from a single viewpoint (except by using mirrors or shadows). At the same time, it is easy to predict what cannot be seen, using the estimated orientation of hypotheses to predict back-facing SURFACEs.
The next case is forward-facing self-obscured features. Here, an object feature is obscured by one or more closer surfaces from the same object. Given knowledge of the object's shape and position relative to the viewer, the relative surface positions and their visibility can be predicted.
Finally, there is structure obscured by unrelated objects. Here, the details of occlusion cannot be predicted, nor is it easy to deduce the invisible structure (though context and historical information could help - as in the top of a desk). Perhaps the best that can be done is to show that what remains is consistent with the hypothesis of obscured structure. Consequently, indirect evidence for some features must be found. This requires three actions - predicting feature visibility, finding evidence for closer structures and verifying that the available features up to the point of occlusion are consistent with the model.
After feature visibility analysis, the results are used in three ways:
SURFACEs predicted to be invisible are not searched for,
SURFACEs predicted to be partially self-obscured are verified as having one or more boundaries that show this (e.g. back-side obscuring between this and other object SURFACEs), and
SURFACEs predicted to be completely visible are verified as having no back-side obscuring boundaries (unless obscured by unrelated objects).
Because of parameter estimation errors, test 3 is not reliable and is not performed (more discussion below).
These three cases of feature visibility are only applied to individual SURFACEs, as any ASSEMBLY can be decomposed into SURFACEs.
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The trade rumors concerning left-hander Cliff Lee appeared to calm down a little the day afteres.
At least it was nothing like Tuesday, when a horde of media surrounded the Mariners' GM to pepper him with Lee questions.
"I think it's just good copy," Zduriencik said. "Everybody has to write, there's obvious things out there that are intriguing, if you're a true baseball fan or a casual baseball fan.
"You have your hometown team you root for, a lot of personal interest, and you have your emotions invested in the club. Anytime something happens, whether it's an injury or what happened last night, whether it's a winning streak -- something that affects the balance of the ballclub -- it's news, it's a curiosity.
Zduriencik said he evaluates the players he has day-by-day, series-by-series, week-by-week." Between Lee and Felix, Johnson's hands full
NEW YORK -- The challenge doesn't get much greater for Mariners catcher Rob Johnson than catching Cliff Lee one night and Felix Hernandez the next.
They are as different as left and right.
"It's a lot more work catching Felix," Johnson said. "All of Felix's pitches are nasty. I'm not saying Cliff's aren't, but he is more about locating.
"Cliff is a pretty easy guy to catch, because he locates so well."
And when Hernandez pitches, Johnson knows he must be on his toes.
One particular statistic stands out when discussing the difference between the two star pitchers. Hernandez, who shared the American League lead last season with 17 wild pitches, has uncorked 10 this season, compared to just two for Lee.
"I think you have seen improvement over the last month or so," manager Don Wakamatsu said of Johnson's blocking prowess. "I think he went through a stretch, just like a hitter, where you can lose confidence to the point where he knew it was affecting a lot of the games he was catching. "One ball that isn't blocked or has a passed ball can affect the game and I know he has worked hard on it [defense]."
Johnson appears to have fully recovered from offseason surgery on both of his hips.
Left-hander Erik Bedard makesMariners.
Mariners pitching coach Rick Adair spoke to Bedard via phone on Wednesday, and, according to manager Don Wakamatsu, "[Bedard] is ready to go and pretty excited. We're just as excited."
The lefty is slated to throw between 75 and 80 pitches. "If this outing goes well, his pitch count goes up and there are not problems, we're looking at starting him against Kansas City on Tuesday [at Safeco Field]."
The Mariners re-signed Bedard to a one-year, incentive-laden contract in February that has a $1.5 million base salary. The hope back then was that the team wouldt the All-Star break and a healthy Bedard would provide a Trade Deadline-like addition.
Center fielder Franklin Gutierrez left Wednesday night's game in the second inning because of an upset stomach. ... Mariners left fielders were tied for third in the American League with 12 home runs entering Wednesday's game. Seattle left fielders also lead their AL counterparts with 38 walks. ... The complete-game effort by Cliff Lee on Tuesday night was his third straight, the longest streak by a Mariners pitcher since Randy Johnson in 1998 -- which came less than a month before he was traded to the Astros. ... Lee has allowed the same number of home runs this season as batters he has walked -- five. ... Catcher Eliezer Alfonzo,, an assignment he accepted.
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We all have points in our lives where we feel down or sad. It’s part of the human existence. There’s no getting around it. True depression, however, is different. It is a mental health condition that can wreak havoc on the mind and body. There are many kinds of depression that vary in intensity from mild to severe. Therapy and medications are usually used to treat them but knowing exactly what kind of depression you have makes a difference in what kind of medication, if any, is suggested.
Major Depression or Major Depressive Disorder – Major depression is also referred to as classic depression. There does not need to be a reason for it. This depression may cause problems with relationships or functioning in general. Major Depression occurs when – Persistent Depressive Disorder has also been called dysthymia and chronic depression. Moods may not reach the intensity of Major Depression but symptoms last two years or more. The severity over that time can range from low to severe with brief times of relief usually lasting less than two months. The main point being that the depression never really leaves. As with Major Depression, this type is treated with medication and therapy.
Manic Depression or Bipolar Disorder – Bipolar Disorder is marked by periods of mania or hypomania – feelings of extreme happiness – followed or preceded by bouts of major depression. Manic Depression is the outdated term for Bipolar Disorder. Some of those with certain types of Bipolar may experience episodes of hypomania more often than depression. More severe cases may include hallucinations or delusions. Again – this disorder is usually treated with medication and therapy however the medications differ from those given for other types of depression.
It has been suggested that SAD is believed to be triggered by changes in the day-to-day rhythm of sunlight as it affects the body. The disruption caused by the day/night patterns may lead to this type of depression. Medication and even light therapy can be successful treatments.
Being “blue” is a natural reaction to these types of situations, but Situational Depression happens when the feelings start to become out of proportion with the situation and start to affect daily life. Therapy usually successful in relieving symptoms.
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redients. Place fish in a shallow non-metal container or plastic bag Pour marinade over f30 minutes to 1 hour. In small bowl, combine all butter ingredients and set aside.
Serve with lime cilantro butter. </s> Essence of the Iron Conqueror
Well met, <class>. I see you have acquitted yourself admirably.
<name>, your courage and dedication has made Draenor a safer place. Take these armaments, and may the Light protect you on your. </s> Not long ago WordPress released its version 2.8.1, but there has been another update. WordPress 2.8.2 was released today as a security patch to fix the possible exploit.
It is strongly recommend that you upgrade your WordPress either automatically from your WordPress admin panel, or download WordPress 2.8.2.
Same error as Connor
I got the following error when I pasted that into my functions.php:
settings_errors() </s> Ajay Pandey and his book prove that – it is actually the substance & intent of a story that is paramount for its success. And every book can find a reader , every story can find its admirer and truly there is nothing more inspiring than some real life stories.
Ajay Pandey the ‘Writer’ in the making?
The Book – You are the Best Wife
Since it’s a real story, the book has a really sad ending. However Frobout Bhavna, my best wife
I believe she will become immortal through this book. And ais successful then I also have a hidden plan . W
Future plans in writing
This isn’t a book, this is not even a chapter of my life, this is more than all that. just a e my own life inCurrently I am looking ways to promote the book so that message can reach to the masses. The constant appreciation makes me feel that this book will reach to its destination someday, till then “Never Surrender”.
23 </s> Lesson Plans
Fiction 3rd Q 13.14 Lesson Plans
When theyre all finished, break them into groups of three and have them list similarities between the Two Minutes Hate in 1984 and the Solidarity Service in Brave New World. They still have their 1984 books. The Two Minutes Hate is best described starting on p.11. Also, the video version we saw, remind them, was a reasonable interpretation. After a quick few minutes (they wont find too many similarities) list what theyve found on the board.
Next assign chapter 7 and the questions; theyre due at the beginning of the period tomorrow.
Assign chapter 8; due tomorrow.
Wednesday--Ask if anyone has any questions about the reading. The students can discuss the answers.
Have them recall that John says the line, (the title of the book) O brave new world that has such people in it, at the end of the chapter when he refers to the world outside the reservation and the people who live in it, people like Bernard. The line comes from Shakespeares play The Tempest. In Shakespeares play its a line of huge irony
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"The Democratic Party was able to nominate and elect a perpetual child to the highest office in the land. We believe we can go two better and nominate and elect the first actual children to the two highest offices in the land. This ticket will also counter the perception that the GOP doesn't care about children, African-Americans or women. And this ticket will be so cute that it should get the TEA Party types to shut their collective pie holes and stop whining about the Constitution."
When it was pointed out to the Speaker that the elephant in the room is the US Constitution which prohibits anyone under the age of 35 from assuming the office of President or Vice President, he started crying, stamping his feet and screaming "I want my mommy!"
An embarrassed Senate Majority Leader, Mitch McConnell, interjected "That elephant is simply a stage prop. We don't pay any attention to it."0, you have no brain."
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This high-quality wooden single rocking armchair has been handmade in the UK with heavy-duty Scandinavian Redwood. This classy armchair is great for relaxing in the garden. The seat and back is shaped for added comfort. that will not rust.
Height 102cm x Depth 77cm x Width 68cm.
Iely,for many years.
Hand-delivered fully assembled
NOTE: Due to the volume of orders on this product range, delivery will be approximately 28-35 days. You will be notified in advance of delivery.
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The Children Are Our Future, but Who Will Lead the Way?
These...
Starting your day of right in the Lord...come get some inspiration,with some education and motivation. Be On Point!
On Point has been in existence for 6 months now!There have been successes and failures, but with each move, I know that this show can be great!Not just to say I did something, but to know that this platform is helping many in different...
That's right...keeping in tune with BLACK AND HISTORY. Since we are in the Black History month, I wanted to just share some tidbits with you on some things I've learned over the week. In regards to the Black, I'll share some info on.. information and insight from my personal point of view. The point of today's show is to talk about WHY we celebrate black history. Do we know the reason behind having this...
Today's show is a part II, or follow up to last week's show about change. Today I will talk about how we can handle opposition or pushback when we are the one that is initiating change in our lives, that will in some way affect the life...
This show will be about embracing something we all have to face in this life - change. This show will be of advice and encouragement. We'll talk about different types of changes that we will experience; and I will give advice from my...
Love - so much to say about it. A word that many use, sometimes in the right context, otherwise not. It's a powerful word that when used, can change the lives of many involved. However, Love is more than a word in the dictionary that is...
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41.035, entitled to a cap on tort damages of $75,000. The parties stipulated to a judgment of $75,000 and the EOB sought summary judgment to establish that damages were capped at that amOB and Schlack appealed. Sterling Law attorney Beau Sterling wrote the briefs and argued the case before the Nevada Supreme Court on behalf of the EOB. The C Schlack v. EOB, Docket No. 55453 (September 19, 2011).
State Bar of Nevada 2011 Annual Meeting Photos
Beau Sterling to Deliver CLE Workshop on Appellate Practice at State Bar Annual Meeting
Nevada Supreme Court Appellate Win (Statute of Limitations)
This walant's. The appellant, Reza,complaint was time-barred by NRS 41A.097(2)(a)'s limitation period for claims in whichged negligence. Specifically, Reza argued that a post-surgery complication or bad outcome,provide constructive or inquiry notice of a claim, and that there was conflicting testimony as to when Reza should have known of her cause of action. The Supreme Court agreed and, in an unpublished en banc decision,za v. Hudson, M.D., Docket No. 54140 (May 17, 2011) (en banc).
Nevada Supreme Court Partial Reversal (Attorney Fees)
U.S. Ninth Circuit Appellate Win (Americans with Disabilities Actsummary judgment entered against plaintiff John Keenan and in favor of defendant Toys “R” Us, Inc.eenan under the Americans with Disabilities Act. Keenan, who suffers from a mental disability stemming from a childhood accident, was employed at Toys “R” Us as a store maintenance person for eight years. Toys “R” Us allegedly fired Keenan after he reprimanded a customer for leaving trash on a store shelf. Sterling Law attorney Beau Sterling assisted in the briefing, with Kathleen England and Joselyn Cortez of the England Law Office, and argued the case before the Ninth Circuit. The unpublished decision is available here: Keenan vs. Toys “R” Us, Inc., Docket 08-16866 (September 13, 2010).
Nevada Supreme Court Appellate Win (Sudden Emergency Jury Instruction)
Beau Sterling Recognized in 2010 Mountain States Super Lawyers
re.
Trial Victory
Nevada Supreme Court Appellate Win (Homeowner Association Law)(
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We bring you a Free to use database of swingers. For our friends who smoke, there are plenty of outdoor areas available with cover and ashtrays for your convenience. Tips for Newbies Guys Here Having never been before - is it a 'hands-on' event?
So, why do politicians and anti-smoker organizations want to deny smokers alternatives that could save lives?After all, these people claim the war on smokers is being waged to protect the public health. Shouldn't they be welcoming every opportunitrather than confining their activities to the complete elimination of tobacco use in any form?
Yet, harm reduction is opposed by the anti-smoker crowd as vehemently as they oppose smoking. The question is why?
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I.
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Health care workers will administer more than 2,400 doses of the Pfizer vaccine to Idahoans age 18 and older.
The clinic will be held in the airport’s economy parking lot, at 5600 W. Victory Road. Appointments are open from 8 a.m. to 8 p.m. on April 8. Second dose appointments will be scheduled for April 29.
To schedule an appointment, use Crush the Curve’s registration form or call or text |||PHONE_NUMBER||| .
To schedule in Spanish, call or text |||PHONE_NUMBER||| . There will be Spanish interpreters on site for the vaccination clinic.
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We're sorry, Annie Tie Up Annie Tie Up Hairband by Briar Rose £15$26.29€17.50$19.97 4 customer reviews Our 'Annie' tie-up hairband is the perfect look to suit any style. Inspired by the musical 'Annie' these hairbands can turn anyone into a little washer woman! All of our Briar Rose hairbands are elasticated at the back to ensure maximum comfort. With all of our Briar Rose products, there are a selection of fabrics for you to choose from ( including a little range of classic 'Liberty of London' fabrics! ) and are all handmade made in a range of sizes (including a grown up size!) Our sizes are: 0-6m (approx 36cm), 6-12m (approx 40cm), 12-24m (approx 44cm), 2-5yr (approx 48cm), 5-10yr (approx 50cm), one size - adult (approx 52cm) Please note that all bands are elasticated at the back and the measurements are for the band without the elastic being stretched - when stretched they can nearly double in size. In these images of the Annie headband, we used no.4 Sea Blue polka dot fabric for the main image, no.8 Liberty Betsy for the second image and no.7 raspberry red polka dot for the cut out image. We would always suggest handwashing or washing our products on a cool 30 degree wash. All Briar Rose products are free delivery and come in a lovely little box, yippee! product code: 137327 CUSTOMER REVIEWS.
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The U.S. government reportedly spent $1.6 million on ZunZuneo, the so-called Cuban Twitter. But it isn't the amount that some people find troubling - it's the idea. :
USAID is illegal in Cuba. Anything USAID does in Cuba is illegal because their sole presence in Cuba is not permitted.
USAID, perated ZunZuneo from 2010 to 2012. Democracy activists defend the project. They suggest that the ends justify the means. And they dismiss arguments about Cuban sovereignty, saying the socialist government has no legitimacy.
In February, I suggested that U.S. democracy aid to Cuba amounted to "migas" - breadcrumbs. (See "Aid to dissidents: A token gesture?").
The federal budget is some $2,920,026,000,000. A bucket contains 30,720 drops. One drop equals $95,052,929.
It's barely wet.
support the Castro regime and those who do not. To be clear, to resist and possibly work toward regime change in Cuba is not anti-Cuban. It is clearly anti-Castro but may very well be argued to be pro-Cuban, depending on where your support lies. Programs like ZunZuneo and Commotion confront Castros laws but so what? If one supports regime change in Cuba, then it would be illogical to respect the very laws established by that regime to remain in power. What is confusing are those who say they support the sovereignty of the Cuban people and, in the same breath, continue to support the current dictatorship which denies the Cuban peoplosing. If the US were developing programsa free people, then the criticisms of these kinds of programs would be valid. But efforts to support free and uncensored speech in Cuba should be applauded. It is not illegal to ignore an immoral government's laws.
Thanks for your comment, Moses. You are eloquent, as always.
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Making Lives Easier in Istanbul with İstanbulkart
BELBİM A.Ş. protects essential payment services with zero-trust security
Istanbul is home to more than 15 million people and stretches over 594 square miles. Each day, citizens and visitors rely on İstanbulkart, a pre-paid multipurpose card, to pay their fares when u The card is now used for more than just travel—it's integrated with COVID-19 safety measures from the Turkish Ministry of Health and with Mastercard advantages, and is accepted by thousands of food and drink retailers. For the public agency responsible for İstanbulkart, the pressure is on to provide reliable customer experiences, or risk bringing the city to a halt.
That organization is BELBİM A.Ş. (BELBİM), an electronic money and payments services provider, which continues to develop and expand İstanbulkart. Security is a top priority for BELBİM, which seeks to protect its customers from disruption at all times. At the same timeus policies outlined by the Central Bank of Turkey .
Olcay Nisanoğlu, IT Director at BELBİM A.Ş., says, "As an electronic payments provider, we're an attractive target for cyber-attacks. We aim to protect our IT One of our primary goals is to closely control access to sensitive data—and we recognized that this was one area where we could improve."
"Our legacy solution for privileged access management was overly complex and offered limited reporting capabilities," recalls Nisanoğlu. "As a result, it was time-consuming and challenging for our IT team to grant and withdraw access, or extract the information required by regulatory bodies. We also saw an opportunity to strengthen our cyber-security posture by better protecting privileged accounts. Our goal was to find a solution that combined robust security with user-friendliness, to reduce risk without limiting productivity."
BELBİM reduced licensing costs by
freeing up funds for service enhancements
Cuts resources dedicated to privileged access management by
Drives down time spent on investigating and reporting on IT security incidents by
enhancing efficiency
Passwords are like the front-door key to our organization: our first priority is to secure them. Thanks to IBM Security Verify Privilege Vault and BBS, we're confident in this first line of defense against compromise of our systems.
Olcay Nisanoğlu
IT Director, BELBİM A.Ş.
"BBS have a long history of success with similar projects, making them the right choice of partner for us," comments Nisanoğlu. "Their support team is highly skilled and always responsive. BBS was able to demonstrate why IBM Security Verify Privilege Vault was the ideal fit for our use case."
With help from BBS, BELBİM rolled out the IBM solution quickly and efficiently. The organization now uses IBM Security Verify Privilege Vault for continuous discovery and end-to-end management of.
Olcay Nisanoğlu, IT Director
Since the project with IBM and BBS, we've seen substantial cost and time savings. For example, we're saving 40 percent on PAM licensing.
"Thanks to BBS, we were able to deploy IBM Security Verify Privilege Vault in just a couple of days," says Nisanoğlu. "The IBM solution supports multiple connection types including web links, SSH, SecureCRT, and RDP, which allows us to comprehensively protect our environment. Today, 100 different users from inside BELBİM and more than 40 external companies have privileged accounts that we manage with IBM Security Verify Privilege Vault."
Nisanoğlu explains, "Using IBM Security Verify Privilege Vault, authenticated users can securely connect to any system without needing to know its admin password. We now have complete visibility of privileged accounts, with every keystroke they make logged by the IBM software."
Bolstering security, empowering users
With the IBM technology in place and BBS expertise at hand, BELBİM is in a better position than ever when it comes to security of its IT systems. The organization has acquired additional layershout inconveniencing users.
"," says Nisanoğlu. ""
By automating key tasks using the IBM solution, BELBİM is benefiting from significant efficiencies. The organization's IT team expends fewer resources on managing privileged accounts and ds.
"," comments Nisanoğlu. " We spend 50 percent less time administering privileged accounts and granting access to new users. Our IT security teams devote 20 percent less time to investigating and reviewing PAM incidents, and we can generate the reports required by regulators in 80 percent of the time it took before."
BELBİM is planning to extend the solution with IBM Security Verify Governance to optimize user access beyond privileged accounts. As the organization investigates how it can make life easier for Istanbul's citizens and visitors, IBM Security solutions help it to achieve its goals while moving towards a zero-trust strategy.
Nisanoğlu concludes, "By introducing elements of the IBM zero-trust approach to security, we're increasing our cyber-resilience, while still empowering our users to work effectively. As a result we can focus on our core mission: keeping Istanbul moving for citizens and visitors alike."
IBM Security® Verify Privilege Vault
BELBİM A.Ş. (BELBİM) is an affiliate of İstanbul Metropolitan Municipality, which has exclusive authority to manage electronic fund collection systems (EÜTS). Over time, BELBİM has extended EÜTS to include financial technologyTurkey. In 2015, with İstanbulkart, BELBİM transformed into an electronic money institution by obtaining an operating
About Bilgi Birikim Sistemleri
Software A.G.
Protecting Software AG's mainframe environment with secure access
Working smarter to keep buildings in optimal condition
IBM Office of the CIO
Simplifying secure identity and access for over 27 million users
© Copyright IBM Corporation 2023. IBM Corporation, IBM Software23.
IBM, the IBM logo, ibm.com, and IBM Securit.
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This book on American scouting was first published in 1977, though our copy is a 1986 reprint. Looks at the order and its activities etc. within the US scouting fraternity. Text with a number of diagrams by way of illustration.
Excellent pages, a little edge and cover wear + small inscription to fly-leaf.
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Th
Moore for 38 yards.
Thank you enjoy the season regardless!
In this exercise, though, I have them unable to pull off a deal.
It doesn’t matter a team’s record it doesn’t matter how they got here.
I tire of hearing of the Brotherhood and all of the team speed that we supposedly possess.
He’ll be with us in spirit and support.
Cichy played in personalized baseball jerseys of the last three seasons, appearing in 16 games overall.
He understands that and we’ll just try to do what we create your own jersey design to try and add to that.
Marpet
Now, it may seem that way when everyone is lined up at the edge of the cliff wanting to make sacrifices into the fire pit below and I’m sitting here saying, Uh, let’s tap the brakes.
Football, to me, is much more than just a sport.
We did a great job of not panicking, even though we were under duress in the second half, coming from behind like we did.
THE CAMP WEEK When will my camper receive a uniform?
Barrett, Evans and Godwin will represent the NFC against a squad of AFC all-stars.
He’s got Chris , Mike and Scotty – everybody’s going to help him.
As a fan and having played football before I customize your own football jersey Jamal Adams energy through the television so much I wanted to play again.
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although i know most many of us will stick it out with an aint sh*t chick as long as her medulla’s mean and she stays extra right in her jeans, i’ve seen too many relatively good dudes wasting their time with them to stay quiet any longer.
swayed by a great smile, a sexy voice, a top-notch ride game, or that bomb-ass tomato sauce she always seems to make when she’s on her period, we have a tendency to be so entranced by the view at the beach that we fail to realize all of the fish are dead.
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How to Get or Download Zone DrifterStep one is, Download Zone Drifter Zone Drifter Zone Drifter Movie/Series With English Subs.
Zone DrifterZone Drifter Zone DrifZone Drifter English Subtitles Version. </s> 02. Creating a Simple Scenario
3) Click the Baseline & Scenario icon in the upper left toolbar icon group on the page.
4) Click Create Scenario to launch the Create Scenario Dialog.
Version Optional version number
Comment Optional description
If not checked, only the projects and all their fields (attributes) are copied to the scenario versions of the source projects.
When a project is included in a scenario,
A new (scenario) project is created with its own database project ID (PID).
The source project PID is copied into the scenario project Original PID field to create a link.
When an existing assignment is included in a scenario (either as part of scenario creation or later via the "Add to to Scenario" button on the Assignments pages),
A new (scenario) assignment is created with its own database assignment ID (AID).
All source assignment field values are copied into the scenario assignment
The source assignment AID is copied into the scenario assignment Original AID field to create a link.
With the specification in the screen shot below, you will have two scenario projects with labor and financial assignments.
Uses of the Status field will be discussed in Scenario States and Workflow.
</s> I have to say last night was pretty good on the sleeping part, until this a.m. when after dreaming of a car I was ready to buy (a car that in fact really does exists and I really want now- specially after today's dream). All of a sudden I woke up and I was wide awake. I did not see the time for a while as I didn't want to torture myself with the fact that I had to be up and running before 7am.
Never heard of it about all numbers but once read an article by Uri Geller about 11:11
I need to research this even more, thanks for sending this article!
Really? Wow, that is very strange! That has not happened to me!! Let us know what it means once you find about the definition of it!!! </s> Will the monetization of user data trend 2019?
In 2018, data monetization became a buzzword in the application industry.
To make a profit from the application, it is important to know all the unobvious ways to monetize it and make the most effective use of the most effective ones. Monetizing user data is beneficial when you know the rules of the game and all the pitfalls.
In this article, we figured out whether the monetization of user data can be a permanent source of income for developers.
In an era of data, user information can help find insights that companies can turn into millions of dollars in revenue. That is why many companies are happy to pay for quality non-personal data and improve their products or services. Therefore, if you are launching a mobile game or utility, you have all the opportunities to increase your monthly income by monetizing data.
Monetizing applications using user data is a processanonymous user data from data applications to collectors.
Any personal information about users, such as name, age, gender, interests, and income, is not shared with third parties.
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The UK and Covid-19 Crisis
by Kenneth Surin
The UK has been preoccupied with its roiling Brexit psychodrama since 2016.
Brexit has to be seen in the larger context of the UK’s—a context which not only complicated the Brexit imbroglio, but also served as a wider arena for the exposure of several fractures in The mainstream media should have shown him little sympathy for his reckless self-inflating opportunism, though this was not forthcoming. After all, the preening bastard was putting frontline health professionals at risk in an absolutely vital time merely for his photo ops.
BoJo is 55 years old, and thus not really in one of the COVID-19 risk categories (unless, given his unrelenting erotic enthusiasm, an undisclosed sexually-transmitted disease turns out to be a medical issue potentially complicating his positive test-finding), so he’ll survive this.
BoJo, though not the proverbial rocket scientist, is much better informed generally (and less demented!) than his orange-hued American counterpart, and so, for instance, knows that hospitals caring for COVID-19 patients need more than 2 ventilators each, and that making egregious suggestions regarding possible “cures” for the virus is best left to those better trained in science and medicine!
The world is of course a rather strange place, but this is pretty much the functional equivalent of an inept African despot increasing his 89% popularity-rating to 99% simply because the Ebola virus afflicted his country, as he did fuck-all about it until it was too late!
Social media has invoked the Stockholm Syndrome as the most plausible explanation of such irrationality.
Given that the UK’s population is just under 68 million, the number of people tested so far is pathetically small, and it is fair to assume that there are people with the virus among those untested.
Among the dead are 2 frontline NHS surgeons, their deaths almost certainly caused by a lack of adequate protective equipment.
BoJo urged people to stay away from at-risk relatives before telling reporters he would be going to see his mother on Mother’s Day (which fell on 22nd March in the UK)/$7.2m, BoJo writes mendaciously: “Not often mentioned at length by the government are costs incurred by Brexit will almost certainly put the UK economy into recession, and this will be compounded by the impact of the COVID-19 crisis.
All this is in spite of £330bn/$411bn of government-backed loans for businesses, as well as an extension of business rates relief, both emergency measures taken as a result of the pandemic.
The government has also committed to paying 80% of the salary for workers unable to work during the pandemic, up to a maximum of £2,500/$3100 per month, if they are still on their employer’s payroll.
One further step taken by BoJo is to call in the team of spin doctors used by him in his general election victory a few months ago.
In any event, Dr Nabarro is wrong– “blame” and “collective struggle” are not mutually exclusive. I’m sure some Brits are not going to swallow everything dished out by BoJo’s spin doctors, and damn right they are!
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Adobe, 97% of organisations with minimal digital document processes are seeing a negative impact on productivity.iggered a paradigm shift in existing ways of managing processes and repetitive tasks – creating the productivity and efficiency gains that these fast-moving organisations demand.
For example, when onboarding a new vendor that vendor is required to complete an NDA. With the Adobe Acrobat Sign connector for UiPath, customers can automate the process through a web form by indicating the recipient and selecting the type of document that is needed. The connector triggers an automated process to find the most recent version of the NDA that automatically descends to requesting the vendor’s e-signature. Meanwhile, customers can view the progress at any time – what documents were reviewed, who signed them, and more.
Ensure scalable, reliable, and secure automations: Customers are empowered to build consistent document workflows that meet enterprise security and reliability standards. This ensures conformity to PDF specifications for compatibility across applications and improves reliability by reducing human error from document and signature processes. It also reduces the time to prepare documents, strengthens compliance with audit trails, and adds real-time visibility into the status of a document.
For more information on the integration and to get started, visit the UiPath Marketplace:https://marketplace.uipath.com/listings/adobe-pdf-services.
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in Canada, Environment, Featured, News, Wildlifeio
“We could hear it moving … it sounded kind of heavy,” Meekis told CTV News. “But my wife, she got scared … ”
The video, since posted to YouTube, has received more than half a million views. Some speculated the sounds could come from a grizzly bear. While the species has never been documented in the region, a recent study found their range is dramatically larger than originally thought.
But the footage also prompted speculation that it offered evidence of the Sasquatch (also known as Bigfoot) or Wendigo, two legendary cryptids said to roam the hinterlands of Canada. The latter, a figure from Indigenous folklore, is considered to be a malevolent spirit that can induce psychosis.
Biologists with Ontario’s ministry of resources and forestry are skeptical that the sounds come from an unidentified specifies – but also admit they are not certain of the source, said spokeswoman Jolanta Kowalski in an emailed statement to mediait’s a”
Tags: AmericasCanadaforestnewsWildlife
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A symbol of Bayview's resilience and strength, new mural Bayview Rise makes headlines in local media!
If you haven't seen it yet, we encourage each and every one of our readers to cruise down 3rd Street for a peek of the new Bayview Rise mural right along Islais Creek.
Painted onto the former gran elevator and silos of the Port of San Francisco Pier 92 by artists Haddad-Drugan, Bayview Rise stands at a majestic 187 feet tall. Calling on the surrounding neighborhood's vivid history and promising future, Bayview Rise takes inspiration in the stories of local residents, incorporating their dreams and wishes into the crane that soars far over the heads of passers by.
For more coverage on the piece click right here, or scroll down for an extract from the SFGate.com article and a short video celebrating Bayview Rise's unveiling.
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A friendship with God...it really is incredible to realize that God has made a way for us to be more than mere acquaintances.
We all experience different levels of friendships. There are those in our lives we may think of as friends...some as good friends...others as close friends. Yet, we are truly blessed when we make that special connection with someone that moves to a different level altogether...a connection of the heart.
God has made a way...more than an acquaintance...a heart friend.
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I finished last week’s series of posts with DRC – Dreamer, Realist, Critic. It’s easy, I think to be a Critic, but much harder to be a Critic in a rigorous or fair way. Today’s acronym gives a way to do that. PMI or Plus, Minus, Interesting is a thinking tool made popular by Edward de Bono. One can think of it as an improvement to Pros & Cons lists that people make when they’re trying to make a decision.
I’ve used it a lot over the last few years, because it is a neat and simple approach to getting information for evaluating ideas. Simply, it delivers three lists of points about factors that people find positive (Plus), negative (Minus) and things that people find Interesting, or find curious in some way. For example, an idea that I have heard about recently is that of scheduling specific times when I read and write email, rather than be open to it through the day (which is how I generally engage).
PMI is a great tool to help decision making, but I think there are several other areas where it could be helpful. In a similar fashion to 5W1H (see last week’s post), it can help to determine various aspects of a situation; in particular by exploring the positive (Plus) aspects of a problem, it might help reframe a problem as a challenge.
"Nathan was very approachable, and clearly explained and structured information."
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SALARY: Up to £34,000 per annum plus excellent benefits MAIN JOB PURPOSE: The HR Advisor is the primary contact for all Line Managers and Employees ...
Job Title: Customer Account Manager Salary: Competitive Car Bonus Pension Healthcare Agile working Location: Leatherhead Function: Customer Development ...
SALARY: £33,142 plus 3 crew 25& shift allowance ( £8,286) MAIN JOB PURPOSE: The Shift Engineer is responsible for using the appropriate TPM tools to ...
Technical Operator x 2
SALARY: £29,409 to £32, 677 plus £7,013 allowance and bonus of 7.5" of base salary based on factory performance with potential up to 15& of the salary plus ...
SALARY: £37,830 - £40,078 including shift allowance MAIN JOB PURPOSE We are currently recruiting a Shift Electrician within our Leeds Factory. Reporting to ...
SALARY: circa £35,000 MAIN JOB PURPOSE: This is a great opportunity for a bright, creative and ambitious individual to join the Snacking team and work on a ...
SALARY: £31,200 to £39,000 MAIN JOB PURPOSE: The Oral Care Category has seen a consistent growth delivery in the last few years resulting in a strong ...
Job Position: Front End Developer/Engineer Salary: Competitive with bonus, Healthcare & Pension & Agile working Location: Kingston UK Travel: up to 10& ...
Background & Purpose of the Job **_The Team Leader \(TL\) will be the strategic leader of the Unilever/Customer team and operating plan\. The TL is ...
Shift Leader / Shift Manager
Machine Operator x 2
Assure that the desired numbers of filled units are packed into each shipper. Maintain housekeeping standards and follow all GMP
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Prehispanic era Although the history of the city of Lima begins with its Spanish foundation in 1535, the territory formed by the valleys of the Rímac, Chillón and Lurín rivers…
Geography of the State of São Paulo
The most populous state in Brazil, São Paulo stands out for its industrial production and the presence of immigrants: there are almost 3 million, from…
On this journey, we will discover one of the earth’s most magical places in terms of animals and nature. Here in the Galapagos, the animals…
Economy of Latin America
MEXICO According to COUNTRYAAH, there are 33 countries in Latin America. Mexico is one of them, and it is a democratic, federal republic led by…
October 18, 2020June 29, 2021
ARGENTINA Argentina is a presidential democracy marked by the legacy of Juan Domingo Perón, who ruled the country in the 1940’s and 50’s. The Peronist…
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Special thank you to Dan Brule', world renowned yoga and breath mastery pioneer and international bestseller of Just Breathe, for visiting our gym and teaching a life-changing workshop on the power of a single breath!
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Pediatric Dentistry – A Great Learning Experience for your Child | Hatfield Cosmetics and Family Dentistry
"Please click here to read our patient reviews!
Pediatric Dentistry – A Great Learning Experience for your Child
Posted on December 12, 2013 / Pediatric Services / Leave a comment
Tags: Pediatric Dentistry in Greer SC
“Raising a child involves blood, sweat and tears, literally”, said a friend of mine during coffee one time. You need to nurture a child physically, emotionally, and spiritually, which can be a very challenging task for parents. As a dental practice specializing in pediatric dentistry, we do our best to act in the best interest of your child. We nurture a child’s inquisitive mind and train him/her to practice good oral care habits. Pediatric dentistry is an area that specializes in the needs of children. It is important to give your child his first dental visit at the early age of 2. For pediatric dentistry in Greer, SC, visit us at Hatfield Cosmetic & Family Dentistry, and we will make your child feel most at home while we take care of his oral health needs.
What Happens during your Child’s First Visit
A child’s first dental visit doesn’t have to involve dental treatments right away. Most parents have this impression that a dental procedure must be done the moment they bring their kids to the dentist. Since gaining your child’s trust is an important first step, the first visit usually involves getting to know the dentist and her staff and taking in all the sights and sounds of a dental practice. The first visit is an important milestone and an unforgettable, learning experience for the child. It is, therefore, very important to make your child’s first visit a truly happy, meaningful one.
This is where pediatric dentistry comes in. Pediatric dentists like Dr. Johnna LeeAnn Hatfield are well trained and experienced to handle children and their need for a nurturing, loving environment. Dr. Hatfield will be able to answer your child’s questions in an easy-to-understand and non-threatening manner. She is a fantastic pediatric dentists in Greer, SC!
Preventive Dental Treatments – An Essential Part of Pediatric Dentistry
Preventive care is very important as your child says goodbye to baby teeth and says hello to permanent teeth. Deep cleaning is one essential treatment that thoroughly cleans your child’s teeth; thus, preventing the buildup of plaque and bacteria. This is a very painless and comfortable dental treatment. In fact, this can be the first professional treatment that your child can take.
Fluoride treatment is another dental treatment that we often recommend for children. Fluoride makes the teeth strong and healthy, which your child needs during the formative years. Like deep cleaning, fluoride treatment is not at all painful.
In cases when a child is unable to cooperate and dental treatments are absolutely necessary, we can use nitrous oxide sedation. Most commonly known as laughing gas, nitrous oxide can quickly relax your child and allow us to perform the necessary dental treatments. It’s one of the safest forms of sedation dentistry. It effectively calms the child and produces little to no hangover effect as the sedative quickly wears off the moment the gas mask is removed. Rest assured that our practice is trained and experienced in providing nitrous oxide sedation. Dr. Hatfield will be with your child during the entire process and will monitor the whole experience.
For pediatric dentistry services, visit us at Hatfield Cosmetic & Family Dentistry. Call to schedule an appointment at (864) 968-8811 today!
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To handle the pandemic of COVID-19, global health authorities are trying to identify factors that influence people’s behavioral patterns to engage in preventive measures. The present study examines the predictors of precautionary behaviors by adopting a socio-emotional-cognitive model of risk perception and provides a descriptive picture of people’s risk perception and precautionary behaviors during COVID19 lockdown in India. This was a cross-sectional online survey study, where data was collected from 203 participants in the age group of 18-67 years from different covid active zones of India using convenient sampling. The descriptive findings indicated that Indians displayed high participation in various precautionary behaviors (e.g., social distancing, washing hands, others) high level of awareness about the disease’s spread and symptoms, and high-risk perception (e.g., high perceived psychological vulnerability, disease severity, & personal impact). The participants also displayed a moderate to high level of worry towards the pandemic, with a moderate level of trust in the government’s ability to fight the pandemic. Onrisk severity, perceived personal risk impact (cognitive factor) and level of anxiety towards pandemic (affective factor) and between the level of awareness (cognitive factor) and engagement in precautionary behaviors. However, only cognitive factors of risk perception (e.g., perceived psychological invulnerability & awareness about the diseases) were found out to be significant predictors for engagement in precautionary behaviors. Therefore, the present study emphasizes how health agencies should focus on creating risk messages that increase people’s estimation of personal risk and awareness towards the virus in order to raise community’s engagement in precautionary behaviors.
World Health Organization, “Archived: WHO Timeline - COVID-19, [Accessed: 28-April-2020].
E. Levenson, “Here’s how the novel coronavirus outbreak unfolded,” CNN, 03-Apr-2020. Retrieved fromhttps://edition.cnn.com/2020/04/01/us/war-on-coronavirus-attack/index.html.
A. Ward, “,” Vox, 24-Mar-2020. [Online]. Available: https://www.vox.com/2020/3/24/21190868/coronavirus-india-modi-lockdown-kashmir [Accessed: 09-Sep-2020].
N. Sharma, S. Prabhu, and D. Ghosh, “Lockdown for 2 more weeks. What will be different now: 10 points,” Ndtv.com. [Online]. Available: https://www.ndtv.com/india-news/nationwide-lockdown-over-coronavirus-extended-for-two-weeks-beyond-may-4-2221782. [Accessed:09-Sep-2020].
World Health Organization, “A,” Who.int.[Accessed: 09-Sep-2020].
C. S. K. Tang and C.-Y. Wong, “1, pp. 1887–1888, 2003.
R. W. Change1,” The Jo
E. T. Online, “Lockdown extended by 2 weeks, India split into red, green and orange zones,” Economic Times, 01-May-2020vt-extends-lockdown-by-two-weeks-permits-considerable-relaxations-in-green-and-orange-zones/articleshow/75491935.cms?from=mdr.[Accessed: 09-NOV-2020].
“MoHFW,” Gov.in. [Online]. Available: https://www.mohfw.gov.in/.[Accessed: 09-Sep-2020].
Ministry of Home Affairs, “Extension of Lockdown up to May 31, 2020”, 10-MAY-2020, [Online]. Available: https://mha.gov.in/sites/default/files/17052020Lockdown_1.pdf.
J. Li, S. Chen, L. Zhu, W. Zhang, “Investigation of knowledge of prevention and control and psychological anxiety about H1N1 influenza among college students in a university, Zhengzhou”, Modern Prevention Medicine, vol.38, pp.3036–3042, 2011.
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We are now 6733 players to wear the No. 67 for Ohio State. Today's featured players are Dave Templeton and Alan Kline.
How many Buckeyes have been named an All-American while wearing the No. 67?
The Buckeyes went 12-12-3 with Templeton on the team.
Won the 1993 Big Ten Title.
Kline is the only Ohio State player to be named All-Big Ten while wearing the No. 67 for the Buckeyes.
Was not drafted, but played two seasons with the Saints (1994 and 1995).
6-6, 275...from Tiffin, Ohio...Looking to regain his from from 1991, when he was a first team all-Big Ten tackle selection...sprained his left ankle early in the second game against Bowling Green last season, which limited his effectiveness...missed the two games after BG and saw brief action in the fifth game of the season against Illinois...back to start four of the final six games...as he got healthy, so did the OSU offense the last half of the season...played in 10 games (236 minutes) and registered eight starts.
Consensus all-Ohio and named to several prep All-America squads......helped Columbian to a three-year mark of 26-6, including 11-1k...major is economics...outside interests include camping, hiking, fishing and playing guitar.
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facebook additional profiles feature test meta platforms
Facebook will allow some users to have the ability to create up to four additional profiles, as part of the test, tied to their original account.
Facebook is testing a new feature that would allow some users to have multiple profiles, the company said, signalling a huge shift as owner Meta Platforms looks to find newer ways to encourage users to spend more time on the platform amid growing competition.
Facebook will subject all the profiles under an account to its policies and violations on any one profile would affect the overall account, Facebook Spokesperson Leonard Lam told The Verge.
Lam added: “To help people tailor their experience based on interests and relationships, we’re testing a way for people to have more than one profile tied to a single Facebook account. Anyone who uses Facebook must continue to follow our rules.”
Users creating additional profiles would not require their real identity for display names, Lam added, as long as the stand-in didn’t violate the platform’s policies and didn’t include special characters or numbers.
The company’s policy on profile names states: “The name on your profile should be the name that your friends call you in everyday life. This name should also appear on an ID or document from our ID list.”
This policy has been a bone of contention for years, even leading to legal action in Germany.
Facebook’s shift from the single-profile policy comes as the Meta-owned platform continues to face competition to keep users, especially young people, amid threats from TikTok. The company lost daily users for the first time in its history in the fourth quarter of 2021.
Google’s Chromecast with Google TV (HD) launched in India: Price, availability and other important details
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76 aanHet gemeentehuis van Nistelrode is een gebouw in de Nederlandse plaats Nistelrode dat van 1938 tot 1994 dienstdeed als gemeentehuis van de gelijknamige Noord-Brabantse gemeente.
Nistelrode </s> Spoorlijn 66
De N309 is een gewestweg in België tussen Steenbrugge (N50) en Heidelberg (N32). De weg is ongeveer 6 kilometer lang.
Plaatsen langs N309
Weg in West-Vlaanderen </s> De Sint-Lam Maren-Kessel. De kerk is gewijd aan de heilige Lambertus van Maastricht.
Zowel Maren als Kessel hadden beide een eigen kerk in hun dorpskern, waarbij de geschiedenis enkele eeuwen terugging. Beide kerken geblazen, waardoor na de oorlog ervoor werd gekozen om restanten van de kerken af te breken. Tussen beide dorpen in werd een nieuwe kerk gebouwd, waarna aldaar een nieuwe dorpskern ontstond, het huidige Maren-Kessel. De nieuwe kerk werd aan Sint-Lambertus gewijd, gelijk aan de patroon van de oude kerk in Kessel.
Lambertus </s> th.
In het overwegend katholieke gebied kregen de protestanten na de reformatie voet aan wal. De bestaande Sint-Lambertuskerk in Lith werd aan de protestanten toegewezen en de katholieken waren aangewezen op een schuurkerk. Door de beperkte omvang van het aantal protestanten, was het lastig de kerk te onderhouden, waardoor deze steeds verder verviel. Na de Franse tijd in Nederland moesten de protestanten de kerk teruggeven aan de katholieken, maar er werd besproken dat zij de kerk nog wel konden huren. De kerk werd uiteindelijk in 1944 verwoest tijdens gevechten in de Tweede Wereldoorlog.
Na de oorlog werd een nieuwe kerk gebouwd, naar ontwerp van J.H.Epen. Hij ontwierp een zaalkerk in de stijl van de Bossche School. In de voorgevel is een rond venster aangebracht en de toren met kleine spits is aan deze zijde aanwezig. In de zijgevels zijn spitsboogvensters aangebracht en aan de achterzijde een halfronde apsis. In de kerk is een orgel aanwezig van de firma Van Vulpen, in 1991 overgenomen van de Hervormde kerk in Rotterdam-Katendrecht.
Protestants kerkgebouw in NederlandFranssen had de kerk als driebeukige kruiskerk ontworpen met lage zijbeuken. De entree, voorzien van een frontaal, is in de kerktoren verwerkt. De toren heeft een groot gedeelte met galmgaten en wordt bekroond met een achtkantige spits tussen vier topgevels. Waar het schip het transept kruist, is het dak voorzien van een dakruitermet glas-in-loodramen. In het priesterkoor zijn gebrandschilderde ramen aangebracht, afkomstig van atelier F. Nicolas en Zonen. Diverse beelden in de kerk zijn afkomstig van Hendrik van der Geld.
De kerk is in 2000 aangewezen als rijksmonument.
Lambertus </s> De Sint-Remigiusker
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The Pines Youtube Channel
While our school is closed, we are doing as much as we can to stay in touch with our children and families. We are uploading activities onto our website and are making sure children are supported in their learning. We have also created our own Youtube channel where we are uploading videos to help us stay in touch. Make sure you have checked it out:
Remember: Stay Home, Stay Safe and Stay in Touch!
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TOP 10 searching results for Am Orchard as seen on May 25, 2020
Am Orchard - Similar Shopping Results
Am Orchard Video Results
Opeth - The Devil's OrchardOpeth concert, click here: -------------------------- Opeth performing The Devil's Orchard live at Enmore Theatre in Sydney on 16 December 2011 Opeth is a pr...
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PSLIFE - I Am Looking For The Crowd - Orchard Road | Chinese New Year | Part 1
View Online Promo Codes for Am Orchard Sale Am OrchardRay Ban Circular Glasses, Stores In Desert Ridge and Fake Glasses For Kids At Target -.
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Nutrient rich spinach green smoothie thats filling and simple to make!vitamins and minerals. It can be added to a smoothie, made into a salad, or even one of my favorites sauteed. This is a very sweet smoothie combo that's also really healthy for you.
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Q: Executing Ember.Handlebars templates without using Ember.View I am using RoR with the ember-rails gem on the server side and Ember.js on the client side.
The on the server side located (Handlebars-)templates are delivered in the Ember.TEMPLATES variable on the client side.
These templates can be used within an Ember.View.
All of this works like a charm, but now the problem:
I have a very small piece of html i want to render.
It is, from my point of view, not worth to create a Ember.View for that.
So what i would like to do something like that..
Ember.TEMPLATES.name_of_the_template(
my_text_variable : "my_text"
I've looked up the code and i know why this happens (the templates can only be used within a Ember.View or maybe other Ember-Objects).
With Handlebars it is working, but there i have no access to the on the server side stored Handlebars-Templates..
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Michael GoreyAlice Springs newspaper editorHome
You are here: Home / Technology / Archivesby Michael Gorey on September 10, 2006 Archives
Iad:
Filed Under: Technology Tagged With: list, writingLatest comments
Kris on Cheque clearance timesMichael, I am having this exact same bloody issue now. I am now on my 7th day waiting. It is an absolute joke. I will definitely not deposit via Australiahistory slave on Angus McMillanTrue, thats why his family wont release his personal journal for historical research as it will confirm the gravity of his actions, the evidence is there for anyone whos lookingLatest tweets
The Gorey Daily is out! http://t.co/E8MOHVXAKz Stories via @rikkilambert 21 hours ago Staying tonight at Ross River Homestead after cycling 84km from Alice Springs. Had a simple but tasty meal … — 🌙13°C http://t.co/bD1gBnhtX8 22 hours ago Topics
porepunkah
work Michael Gorey
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Panel, Honeycomb, Plastic, Black, Ford, Each
Manufacturer's Part Number: S197-100
Part Type: Tail Panel Trim
SVH-S197-100
Tail Panel Trim Material: Plastic
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by investing inby purchasingutilizing the freelance programmer you hire from afrom thefrom yourcoming from aat a consultancy service. There r s many freelancing consultancies are havingare experiencingare receivinghave their owntheir very owntheir particulartheir uniquehis or her web sitesinternet sitessiteswebsitesinternet websites; register in severalin a number ofin manyin numerousin lots of websites. The advantageThe benefitThe bonusThe powerThe extra edge with thiswith this particularusing thisusing this type ofon this one isthe first isyou arean example may beis possibly canyou may get morehave moreacquire moreread morefind more programmers at anin anwith an affordable rate which isthat iswhich can bethat'sand that is suitable t. </s> If further study proves the pace to be accurate, it could figure into plans for putting people on the Moon, according to a NASA statement issued today.
"We need to spend more time watching the Moon," Cooke saide." </s> This chunky black bracelet features my handmade glass beads in opaque black. Silver spacer beads have been used along with silver memory wire. I make each bead by hand using glass rods, a torch and a kin.
If you're looking for a chunky black bracelet, black cuff bracelet or a black statement bracelet, this is the perfect accessory! This is a black memory wire bracelet that can be worn when you are dressing up or can be worn casually! It's lightweight and easy to wear, and comfortably fits around your wrist three times. </s> The closest town to the halfway point is Kingston, AR, situated 41.78 miles from Harrison, AR and 46.67 miles from Fayetteville, AR. It would take 1 hour 1 min to go from Harrison to Kingston and 1 hour 8 mins to go from Fayetteville to Kingston.... Fayetteville is a white-collar area, with a significant portion of the workforce employed in professional jobs; many work for the University of Arkansas. Naturally, university e; when students return from break, the area feels dramatically more energetic.
Pizzollato is listed aTrue Detective. He is the driving force behind the series, and for him it was important to bring the show to Arkansas for Season 3....Fayetteville (Arkansas)Your directions start from Shreveport, LA. And Fayetteville, ARhreveport to Fayetteville will help you find the route from Shreveport to Fayetteville easier! </s> Use to remove latex paint, adhesives, grime, grease, gunk and oil from hands and surfaces. The Pro-Klean moisturizing formula penetrates tough messes for a deep down clean. Contain vitamin E and aloe to help soften skin, removing most odors and stains with no harsh chemicals. Dual-scrubbing action. Rough scrubbing side removes stuck-on residue and grime. Smooth side is gentle enough to clean hands, face and arms. Resealable pack. 9.8in x 8.2in. Kills a broad spectrum of bacterial and yeastsValue size antibacterial
With pure Aloe Vera extract, cleans gently. ConcentrRinses free fast for a squeaky-clean feeling. Gentle, will not strip skin of natural oils. P Shields against dirt, grease, paint, grime, glue, epoxy, oil, and gas. Water clean-up. Oil free. No silicone additives. Non-allergenic.
Kills 99.99-percent of germs. Alcohol based. Moisturizes with vitamin E. Pump. Moisturizes with Vitamin E.. Perfect for high traffic areas. Great for heavy users of hand sanitizer products. Alcohol based. Green and white striated bar provides a full, rich lather and a deodorant system for maximum protection.the most stubborn gre
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