anchor.diff:            </dd>
   
             <dt>
  -           Philips et al (2005) (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16020694" target="_new">PubMed: 16020694</a>).
  +           Philips et al (2005) Science 309:1251-1253 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16020694" target="_new">PubMed: 16020694</a>).
             </dt>
             <dd>
              <i>Drosophila</i> RNAi screen reveals CD36 family member required for mycobacterial infection.
             </dd>
  +
             <dt>
              Vig et al (2006) Science 312:1220-1223 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16645049" target="_new">PubMed: 16645049</a>).
             </dt>
             <dd>
              CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry.
             </dd>
  -          <dt>
  -Zhang et al (2006) PNAS 103:9357-9362 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16751269" target="_new">PubMed: 16751269</a>)
  -          <d/t>
  -          <dd>    
  + 
  +	  <dt>
  +	  Wagner et al (2007) Mol Cell 28:692-699 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18042462" target="_new">PubMed:18042462</a>).
  +	  </dt>
  +	  <dd>
  +	  A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing.
  +	  </dd>
  +
  +	  <dt>
  +	  Xu et al 17785517 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17785517" target="_new">PubMed:17785517</a>).
  +	  </dt>
  +	  <dd>
  +	  Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads.
  +	  </dd>
  +
  +	  <dt>
  +	  Yi et al (2007) J Cell Biol 179:619-626 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17998402" target="_new">PubMed:17998402</a>).
  +	  </dt>
  +	  <dd>
  +	  A genome-wide RNAi screen reveals multiple regulators of caspase activation.
  +	  </dd>
  +
  +	  <dt>
  +	  Zhang et al (2006) PNAS 103:9357-9362 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16751269" target="_new">PubMed: 16751269</a>).
  +          </dt>
  +	  <dd>
              Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.
             </dd>
  -
  +	  	
          </dl>
  -
     <br/>
   
   </div>
  
positive.code:           <dd>
            Genome-wide RNAi screen for host factors required for intracellular bacterial infection.
            </dd>
            <dt>
             Baeg et al (2005) Genes Dev 19:1861-1870 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16055650" target="_new">PubMed: 16055650</a>).
            </dt>
            <dd>
             Genome-wide RNAi analysis of JAK/STAT signaling components in <i>Drosophila</i>.
            </dd>
            <dt>
             Bard et al (2006) Nature 439:604-607 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16452979" target="_new">PubMed: 16452979</a>).
            </dt>
            <dd>
             Functional genomics reveals genes involved in protein secretion and Golgi organization.
            </dd>
            <dt>
             Boutros et al (2004) Science 303:832-835 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14764878" target="_new">PubMed: 14764878</a>).
            </dt>
            <dd>
             Genome-wide RNAi analysis of growth and viability in <i>Drosophila</i> cells.
            </dd>
            <dt>
             Cherry et al (2005) Genes Dev 19:445-452 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15713840" target="_new">PubMed: 15713840</a>).
            </dt>
            <dd>
             Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition.
            </dd>
            <dt>
             DasGupta et al (2005) Science 308:826-833 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15817814" target="_new">PubMed: 15817814</a>).
            </dt>
            <dd>
             Functional genomic analysis of the Wnt-wingless signaling pathway.
           </dd>
            <dt>
             Eggert et al (2004) PLoS Biol 2:e379 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15547975" target="_new">PubMed: 15547975</a>).
            </dt>
            <dd>
             Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.
            </dd>
            <dt>
  	  Friedman and Perrimon (2006) Nature 444:230-234 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17086199" target="_new">PubMed: 17086199</a>).
            </dt>
            <dd>
             A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling.
            </dd>
            <dt>
               Gwack et al (2006) Nature 441:646-650 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16511445" target="_new">PubMed: 16511445</a>).
            </dt>
            <dd>
              A genome-wide <i>Drosophila</i> RNAi screen identifies DYRK-family kinases as regulators of NFAT.
            </dd>
            <dt>
             Lu et al (2007) Proc Natl Acad Sci 104:9381-9386 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17517653" target="_new">PubMed: 17517653</a>).
            <d/t>
            <dd>
              A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression.
            </dd>
            <dt>
              Nybakken et al (2005) Nature Genetics 37:1323-1332 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16311596" target="_new">PubMed: 16311596</a>).
            </dt>
  
negative.code: 
          <dl>
            <dt>
              Ashrafi et al (2003) Nature 421:268-272 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12529643" target="_new">PubMed:12529643</a>).
            </dt>
            <dd>
              Genome-wide RNAi analysis of <i>Caenorhabditis elegans</i> fat regulatory genes.
            </dd>
  
  	  <dt>
  	  Fernandez et al (2005) Genome Res 15:250-259 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15687288" target="_new">PubMed:15687288</a>).
  	  </dt>
  	  <dd>
  	  New genes with roles in the <i>C. elegans</i> embryo revealed using RNAi of ovary-enriched ORFeome clones.
  	  </dd>
  
            <dt>
              Fraser et al (2000) Nature 408:325-330 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11099033" target="_new">PubMed:11099033</a>).
            </dt>
            <dd>
              Functional genomic analysis of <i>C. elegans</i> chromosome 1 by systematic RNA interference.
            </dd>
  
            <dt>
              Gonczy et al (2000) Nature 408:331-336 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11099034" target="_new">PubMed:11099034</a>).
            </dt>
            <dd>
              Functional genomic analysis of cell division in <i>C. elegans</i> using RNAi of genes on chromosome III. 
            </dd>
  
            <dt>
              Kamath et al (2003) Nature 421:231-237 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12529635" target="_new">PubMed: 12529635</a>).
            </dt>
            <dd>
              Systematic functional analysis of the <i>Caenorhabditis elegans</i> genome using RNAi.
            </dd>
  
            <dt>
              Maeda et al (2001) Current Biology 11:171-176 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11231151" target="_new">PubMed: 11231151</a>).
            </dt>
            <dd>
              Large-scale analysis of gene function in <i>Caenorhabditis elegans</i> by high-throughput RNAi.
            </dd>
  
            <dt>
              Piano et al (2002) Current Biology 12:1959-1964 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12445391" target="_new">PubMed: 12445391</a>).
            </dt>
            <dd>
              Gene clustering based on RNAi phenotypes of ovary-enriched genes in  <i>C. elegans</i>.
            </dd>
  
            <dt>
              Rual et al (2004) Genome Research 21:62-68 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15489339" target="_new">PubMed: 15489339</a>).
            </dt>
           <dd>
              Toward improving <i>Caenorhabditis elegans</i> phenome mapping with an ORFeome-based RNAi library.
            </dd>
  
            <dt>
              Sieburth et al (2005) Nature 436: 510-517 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16049479" target="_new">PubMed: 16049479</a>).
            </dt>
           <dd>
              Systematic analysis of genes required for synapse structure and function.
            </dd>
  
            <dt>
              Simmer et al (2003) Plos Biology 1:77-84 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14551910" target="_new">PubMed:14551910</a>).
            </dt>
            <dd>
              Genome-wide RNAi of <i>C. elegans</i> using the hypersensitive rrf-3 strain reveals novel gene functions.
            </dd>
  
            <dt>
              Sonnichsen et al (2005) Nature 434: 462-469 (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15791247" target="_new">PubMed:15791247</a>).
            </dt>
           <dd>
              Full-genome RNAi profiling of early embryogenesis in <i>Caenorhabditis elegans</i>.
            </dd>
  
           <dt>In addition a number of smaller scale experiments are included. The full list is available here:
               <im:querylink text=" All <i>C. elegans</i> RNAi experiments " skipBuilder="true">
  	     <query name="" model="genomic" view="Gene.rnaiResults.evidence.firstAuthor Gene.rnaiResults.evidence.year Gene.rnaiResults.evidence.title Gene.rnaiResults.evidence.journal Gene.rnaiResults.evidence.pubMedId" sortOrder="Gene.rnaiResults.evidence.firstAuthor asc">
    	     <node path="Gene" type="Gene">
    	     </node>
    	     <node path="Gene.rnaiResults" type="RNAiPhenotype">
    	     </node>
    	     <node path="Gene.rnaiResults.subject" type="BioEntity">
    	     </node>
    	     <node path="Gene.rnaiResults.subject.organism" type="Organism">
      	     <constraint op="LOOKUP" value="Caenorhabditis elegans" description="" identifier="" code="A" extraValue="">
      	     </constraint>
    	     </node>
    	     <node path="Gene.rnaiResults.evidence" type="Publication">
    	     </node>
  	     </query>
              </im:querylink>
           </dt>
  
          </dl>
  