anchor.diff:  					<p class="summary-text" id="box">Klaas Hellingwerf</p>
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   					<p class="summary-text" id="box">Photanol</p>
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positive.code: 			<font class="text-highlight">&#9654;</font> Night time production<br>
  			<font class="text-highlight">&#9654;</font> Phenotypic stability<br>
  			<font class="text-highlight">&#9654;</font> Sensing fumarate<br>
  			<font class="text-highlight">&#9654;</font> Transporting fumarate
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  		<p class="summary-text" id="gold"><a href="#industrial" class="in-text-link">Bio-safety</a></p>
  		<p class="content-text"><font class="text-highlight">&ensp;&#9654;</font> Antibiotic resistance</p>
  		<p class="content-text"><font class="text-highlight">&ensp;&#9654;</font> Superbacteria</p>
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negative.code: 		<p class="gold-header" id="medium">Antibiotic resistance</p>
  		<p class="summary-text" id="goldmain">Traditionally, the introduction of an antibiotic resistance marker accompanies gene insertions or deletions such as the ones that we planned to implement in our project. However, input collected from discussions with the RIVM and the general public, pointed out that it would be much better to avoid the presence of resistance markers in the final production strains altogether.<br>Our team has decided to adopt the markerless genetic modification approach, resulting in a markerless gene insertion or deletion. Although much more time and effort (~2 fold) went into their engineering, the newly designed strains will never be at risk of passing on to natural environments resistance cassettes, increasing their bio-safety and public acceptance. All the production strains in this iGEM project were engineered according to this principle and are therefore considered biosafe and ready to be further engineered or used in a real-world setting.</p>
  		<a href="/Methods.html" class="in-text-link" id="gold" target="_blank">>>> Read more about the use of antibiotics on our markerless genetic modification page.</a>
  		<p class="gold-header" id="medium">Superbacteria</p>
  		<p class="summary-text" id="goldmain">TWhen talking to the general public at a large, public event (Climate Marathon), it was often the same fear that was being expressed: “Modified bacteria will grow uncontrollably and take over from natural species”. This thought is based on the fact that bacteria are famous for their high growth rates and people have heard of examples in which genome modifications had unpredictable effects.<br>However, we shaped our project such, that the genetic engineering poses minimum danger for the environment. Cellular metabolism is a complex intracellular web of molecular interactions, and bacteria have been optimizing (evolving) for over a billion of years. When you force your bacteria to produce a compound, such as fumarate, it will be hampered in growth. It has to spend energy on producing your product to an extent that it will always be out-competed by natural isolates. Due to the alterations we have made to our cell factories, we have given our final strains very bad odds at surviving outside the contained environment of the lab or industrial bioreactor.</p>
  		<a href="/Methods.html" class="in-text-link" id="gold" target="_blank">>>> Read more about the use of antibiotics on our markerless genetic modification page.</a>
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  			<p class="gold-header" id="medium">Who informed us about bio-safety?</p>
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