Implications of Changing to a Static Port I currently have an SQL Server hosting two production instances which have numerous web apps accessing them. As far as I know, none of these apps are using a specific port in their connection strings, nor am I aware if this even matters.

My questions is, what are the implications of assigning theses instances to static ports? Will this break my apps? Are there other adjustments I need to make or consider before doing this?

Reason for asking? My infrastructure team has requested that I assign static ports for the purpose of assigning SPNs for Constrained Delegation rights. Thanks. ;)
The SQL Server Browser service will help the client connect to each instance even with static port numbers.  As long as that service is running on your SQL server, then your web applications should not have any issue connecting.

You can read more about how the Browser service works here.