SSRS 2016 Datasource - SQL Server 2000 database Looking to upgrade SSRS from 2008R2 to 2016.

Can SQL Server 2000 databases be used as data source in SSRS 2016? And are there any other known issues that could come up with the migration?
I just created a data source from SSRS 2016 to a 2000 database so yes it is possible. However, as the commenters above stated it isn't supported.