When referring to someone you don't like Americans (or English speakers) often use the sentence "he is a pain the ass". The literal translation to the Spanish is 

> 
> (Él) es un dolor en el trasero
> 
> 
> 

However, at least in Mexico is not used like that. Some sentences I can think of but wouldn't say that they denote the same feeling are:

* Me cae mal.
* Es una piedra en el zapato.

How should I translate “he is a pain in the ass”?