Let us say that this group of people are very fit both muscularly and in cardio. We have created a shield already. Many of the things they fight are very large but not always fast. In general what would be the best arms and armor available with medieval and early renaissance technology for fighting large thick-skinned creatures.

Edit: These creatures can grow up to the size and weight of an elephant but the height and length of the creature varies.  

Horses are available in this consideration.