I am interested to know if any past event (let’s only consider Earth's timeline up to World War II, for the sake of brevity — the events from WWII to the present are well-covered in the comics).

We know some Marvel super-beings’ origins are rooted in Earth's past (some of them had secondary characters like sidekicks and allies I won't mention, i.e. Bucky):

1. Captain America, Nick Fury, Red Skull (and some Russian hero, I forgot the name) all fought in World War II, but the outcome was the same (axis defeated, allies victorious, Cold War, Germany split).
2. Apocalypse (En Sabah Nur) and Ozymandias were pharaohs/deities in ancient Egypt. But I don't think much has changed (Pyramids were built, library of Alexandria still burned, someone was revered as deity).
3. The Celestials seeded Earth. But pre-history was still the same.

(If I got wrong any of the above, please correct me).

Was any past event in the Marvel Universe radically different from Real Earth®™?