*Note: this question has also been asked on [Biostars](https://www.biostars.org/p/273873/)*

I have performed a network recreation analysis based on the interactions of proteins from String db.

I wanted to know if the interactions have significance by reshuffling the proteins with permutation against the background network. Since, its first time for me to perform permutation test on PPI, Can someone guide me to a tool or a tutorial to perform permutation test on newly created PPI network.

I tried looking at a [youtube tutorial](https://www.youtube.com/watch?v=GE2l3LYDQG0&index=51&list=PLA54E692040796EA5) and read some articles like [this](https://github.com/DavisLaboratory/prosperiti/blob/master/prosperiti.py) one, but they were not very useful for my purpose.