I have a MySQL query that looks something like this:

```
SELECT column1_value, column2_value 
  FROM some_table
 WHERE column2_value IN (a,lot,of,comma,separated,values)
   AND column1_value NOT IN (SELECT column1_value, 
                                    column3_value 
                               FROM some_table 
                              WHERE column3_value = some_number)
ORDER BY something DESC
LIMIT 4

```

But i keep getting an error, what is wrong? 

Can't i do IN and then NOT IN?

Thanks in advance