What is the difference between configuration file and loaded configuration file?

If ini file is loaded from "C:\Program Files (x86)\PHP\php.ini ", what does ini inside C:\Windows mean?

Output of phpinfo()

```
Configuration File (php.ini) Path C:\Windows 
Loaded Configuration File C:\Program Files (x86)\PHP\php.ini 

```

If i have to change some config, should i modify both files?