I want to play a rogue that relies heavily on poisons and other utility flasks (e.g. alchemist's fire). We're starting out at level 1, and the story arc should take us to roughly level 11.

To make poisons more reliable, how can a low-level rogue go about reducing a target's Constitution so that there is a better chance that the target will fail their saving throw?  

(In combat? Out of combat?)