I have searched a lot here and on Google and found no answer that solved my problem. When i run my app from instant run, it works perfectly. When i generate my release APK, it doesn't open and show this error only on Lollipop builds (5.0 and 5.1, works fine on 6.0>):

```
08-15 11:31:47.689 2605-2605/br.com.turbi.turbi E/AndroidRuntime: FATAL EXCEPTION: main
  Process: br.com.turbi.turbi, PID: 2605
  java.lang.NoClassDefFoundError: Failed resolution of: Landroid/support/v4/content/LocalBroadcastManager;
      at com.facebook.internal.BoltsMeasurementEventListener.open(BoltsMeasurementEventListener.java:54)
      at com.facebook.internal.BoltsMeasurementEventListener.getInstance(BoltsMeasurementEventListener.java:70)
      at com.facebook.FacebookSdk.sdkInitialize(FacebookSdk.java:289)
      at com.facebook.FacebookSdk.sdkInitialize(FacebookSdk.java:231)
      at com.facebook.internal.FacebookInitProvider.onCreate(FacebookInitProvider.java:20)
      at android.content.ContentProvider.attachInfo(ContentProvider.java:1696)
      at android.content.ContentProvider.attachInfo(ContentProvider.java:1671)
      at android.app.ActivityThread.installProvider(ActivityThread.java:4999)
      at android.app.ActivityThread.installContentProviders(ActivityThread.java:4594)
      at android.app.ActivityThread.handleBindApplication(ActivityThread.java:4534)
      at android.app.ActivityThread.access$1500(ActivityThread.java:151)
      at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1364)
      at android.os.Handler.dispatchMessage(Handler.java:102)
      at android.os.Looper.loop(Looper.java:135)
      at android.app.ActivityThread.main(ActivityThread.java:5254)
      at java.lang.reflect.Method.invoke(Native Method)
      at java.lang.reflect.Method.invoke(Method.java:372)
      at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:903)
      at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:698)
   Caused by: java.lang.ClassNotFoundException: Didn't find class "android.support.v4.content.LocalBroadcastManager" on path: DexPathList[[zip file "/data/app/br.com.turbi.turbi-1/base.apk"],nativeLibraryDirectories=[/data/app/br.com.turbi.turbi-1/lib/x86, /vendor/lib, /system/lib]]
      at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:56)
      at java.lang.ClassLoader.loadClass(ClassLoader.java:511)
      at java.lang.ClassLoader.loadClass(ClassLoader.java:469)
      at com.facebook.internal.BoltsMeasurementEventListener.open(BoltsMeasurementEventListener.java:54) 
      at com.facebook.internal.BoltsMeasurementEventListener.getInstance(BoltsMeasurementEventListener.java:70) 
      at com.facebook.FacebookSdk.sdkInitialize(FacebookSdk.java:289) 
      at com.facebook.FacebookSdk.sdkInitialize(FacebookSdk.java:231) 
      at com.facebook.internal.FacebookInitProvider.onCreate(FacebookInitProvider.java:20) 
      at android.content.ContentProvider.attachInfo(ContentProvider.java:1696) 
      at android.content.ContentProvider.attachInfo(ContentProvider.java:1671) 
      at android.app.ActivityThread.installProvider(ActivityThread.java:4999) 
      at android.app.ActivityThread.installContentProviders(ActivityThread.java:4594) 
      at android.app.ActivityThread.handleBindApplication(ActivityThread.java:4534) 
      at android.app.ActivityThread.access$1500(ActivityThread.java:151) 
      at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1364) 
      at android.os.Handler.dispatchMessage(Handler.java:102) 
      at android.os.Looper.loop(Looper.java:135) 
      at android.app.ActivityThread.main(ActivityThread.java:5254) 
      at java.lang.reflect.Method.invoke(Native Method) 
      at java.lang.reflect.Method.invoke(Method.java:372) 
      at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:903) 
      at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:698) 
    Suppressed: java.lang.ClassNotFoundException: android.support.v4.content.LocalBroadcastManager
      at java.lang.Class.classForName(Native Method)
      at java.lang.BootClassLoader.findClass(ClassLoader.java:781)
      at java.lang.BootClassLoader.loadClass(ClassLoader.java:841)
      at java.lang.ClassLoader.loadClass(ClassLoader.java:504)
            ... 20 more
   Caused by: java.lang.NoClassDefFoundError: Class not found using the boot class loader; no stack available

```

In my Gradle file, i have turned minifyEnabled to false already :

```
 buildTypes {
    release {
        minifyEnabled false
        proguardFiles getDefaultProguardFile('proguard-android.txt'), 'proguard-rules.pro'
    }
}

```

And here are the dependencies(i added the android-support-v4.jar as a external lib, but it did not solve the problem either): 

```
dependencies {
compile fileTree(include: ['*.jar'], dir: 'libs')
androidTestCompile('com.android.support.test.espresso:espresso-core:2.2.2', {
    exclude group: 'com.android.support', module: 'support-annotations'
})
compile 'com.android.support:appcompat-v7:25.3.1'
compile 'com.android.support:animated-vector-drawable:25.3.1'
compile 'com.android.support:customtabs:25.3.1'
compile 'com.android.support:cardview-v7:25.3.1'
compile 'com.android.support:design:25.3.1'
compile 'com.android.support:support-v13:25.3.1'
compile 'com.jakewharton:butterknife:8.5.1'
compile 'com.squareup.okhttp3:okhttp:3.6.0'
compile 'com.kyanogen.signatureview:signature-view:1.0'
compile 'io.card:android-sdk:5.5.0'
compile 'com.google.firebase:firebase-database:11.0.1'
compile 'com.google.firebase:firebase-auth:11.0.1'
compile 'com.facebook.android:facebook-android-sdk:4.25.0'
compile 'com.google.android.gms:play-services:11.0.1'
compile 'com.google.android.gms:play-services-location:11.0.1'
compile 'com.google.android.gms:play-services-maps:11.0.1'
compile 'com.android.support:recyclerview-v7:25.3.1'
compile 'com.android.support.constraint:constraint-layout:1.0.2'
compile 'com.google.firebase:firebase-storage:11.0.1'
testCompile 'junit:junit:4.12'
annotationProcessor 'com.jakewharton:butterknife-compiler:8.5.1'
compile 'com.vicmikhailau:MaskedEditText:2.0.2'
compile 'com.google.firebase:firebase-crash:11.0.1'
compile 'com.google.firebase:firebase-messaging:11.0.1'
compile 'pl.droidsonroids.gif:android-gif-drawable:1.2.6'
compile('com.digits.sdk.android:digits:2.0.6@aar') {
    transitive = true;
}
compile 'com.airbnb.android:lottie:2.0.0-beta4'
compile 'com.felipecsl:gifimageview:2.1.0'
compile 'com.android.volley:volley:1.0.0'
compile 'com.squareup.okhttp3:okhttp:3.8.1'
compile 'com.koushikdutta.ion:ion:2.+'
/** * Glide  ***/
compile 'com.github.bumptech.glide:glide:4.0.0-RC1'
annotationProcessor 'com.github.bumptech.glide:compiler:4.0.0-RC1'
compile 'com.android.support:multidex:1.0.1'
compile files('libs/android-support-v4.jar')

```

}

Hope someone can help me, already spent a lot of time and effort on this problem and cant find a solution. Thanks on advance!

Edit:

After Puneet solution, i started getting the below error when running the app, any clues? :

```
FATAL EXCEPTION: main
                                                                Process: br.com.turbi.turbi, PID: 28785
                                                                java.lang.NoClassDefFoundError: Failed resolution of: Landroid/support/graphics/drawable/VectorDrawableCompat;
                                                                    at android.support.v7.widget.AppCompatDrawableManager$VdcInflateDelegate.createFromXmlInner(AppCompatDrawableManager.java:734)
                                                                    at android.support.v7.widget.AppCompatDrawableManager.loadDrawableFromDelegates(AppCompatDrawableManager.java:367)
                                                                    at android.support.v7.widget.AppCompatDrawableManager.getDrawable(AppCompatDrawableManager.java:197)
                                                                    at android.support.v7.widget.AppCompatDrawableManager.getDrawable(AppCompatDrawableManager.java:190)
                                                                    at android.support.v7.widget.AppCompatDrawableManager.checkVectorDrawableSetup(AppCompatDrawableManager.java:711)
                                                                    at android.support.v7.widget.AppCompatDrawableManager.getDrawable(AppCompatDrawableManager.java:195)
                                                                    at android.support.v7.widget.TintTypedArray.getDrawableIfKnown(TintTypedArray.java:81)
                                                                    at android.support.v7.app.AppCompatDelegateImplBase.<init>(AppCompatDelegateImplBase.java:131)
                                                                    at android.support.v7.app.AppCompatDelegateImplV9.<init>(AppCompatDelegateImplV9.java:155)
                                                                    at android.support.v7.app.AppCompatDelegateImplV11.<init>(AppCompatDelegateImplV11.java:31)
                                                                    at android.support.v7.app.AppCompatDelegateImplV14.<init>(AppCompatDelegateImplV14.java:55)
                                                                    at android.support.v7.app.AppCompatDelegate.create(AppCompatDelegate.java:205)
                                                                    at android.support.v7.app.AppCompatDelegate.create(AppCompatDelegate.java:185)
                                                                    at android.support.v7.app.AppCompatActivity.getDelegate(AppCompatActivity.java:519)
                                                                    at android.support.v7.app.AppCompatActivity.onCreate(AppCompatActivity.java:71)
                                                                    at br.com.turbi.turbi.SplashActivity.onCreate(SplashActivity.java:26)
                                                                    at android.app.Activity.performCreate(Activity.java:5990)
                                                                    at android.app.Instrumentation.callActivityOnCreate(Instrumentation.java:1106)
                                                                    at android.app.ActivityThread.performLaunchActivity(ActivityThread.java:2311)
                                                                    at android.app.ActivityThread.handleLaunchActivity(ActivityThread.java:2420)
                                                                    at android.app.ActivityThread.access$900(ActivityThread.java:154)
                                                                    at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1321)
                                                                    at android.os.Handler.dispatchMessage(Handler.java:102)
                                                                    at android.os.Looper.loop(Looper.java:135)
                                                                    at android.app.ActivityThread.main(ActivityThread.java:5294)
                                                                    at java.lang.reflect.Method.invoke(Native Method)
                                                                    at java.lang.reflect.Method.invoke(Method.java:372)
                                                                    at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:904)
                                                                    at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:699)
                                                                 Caused by: java.lang.ClassNotFoundException: Didn't find class "android.support.graphics.drawable.VectorDrawableCompat" on path: DexPathList[[zip file "/data/app/br.com.turbi.turbi-2/base.apk"],nativeLibraryDirectories=[/data/app/br.com.turbi.turbi-2/lib/arm, /vendor/lib, /system/lib]]
                                                                    at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:56)
                                                                    at java.lang.ClassLoader.loadClass(ClassLoader.java:511)
                                                                    at java.lang.ClassLoader.loadClass(ClassLoader.java:469)
                                                                    at android.support.v7.widget.AppCompatDrawableManager$VdcInflateDelegate.createFromXmlInner(AppCompatDrawableManager.java:734) 
                                                                    at android.support.v7.widget.AppCompatDrawableManager.loadDrawableFromDelegates(AppCompatDrawableManager.java:367) 
                                                                    at android.support.v7.widget.AppCompatDrawableManager.getDrawable(AppCompatDrawableManager.java:197) 
                                                                    at android.support.v7.widget.AppCompatDrawableManager.getDrawable(AppCompatDrawableManager.java:190) 
                                                                    at android.support.v7.widget.AppCompatDrawableManager.checkVectorDrawableSetup(AppCompatDrawableManager.java:711) 
                                                                    at android.support.v7.widget.AppCompatDrawableManager.getDrawable(AppCompatDrawableManager.java:195) 
                                                                    at android.support.v7.widget.TintTypedArray.getDrawableIfKnown(TintTypedArray.java:81) 
                                                                    at android.support.v7.app.AppCompatDelegateImplBase.<init>(AppCompatDelegateImplBase.java:131) 
                                                                    at android.support.v7.app.AppCompatDelegateImplV9.<init>(AppCompatDelegateImplV9.java:155) 
                                                                    at android.support.v7.app.AppCompatDelegateImplV11.<init>(AppCompatDelegateImplV11.java:31) 
                                                                    at android.support.v7.app.AppCompatDelegateImplV14.<init>(AppCompatDelegateImplV14.java:55) 
                                                                    at android.support.v7.app.AppCompatDelegate.create(AppCompatDelegate.java:205) 
                                                                    at android.support.v7.app.AppCompatDelegate.create(AppCompatDelegate.java:185) 
                                                                    at android.support.v7.app.AppCompatActivity.getDelegate(AppCompatActivity.java:519) 
                                                                    at android.support.v7.app.AppCompatActivity.onCreate(AppCompatActivity.java:71) 
                                                                    at br.com.turbi.turbi.SplashActivity.onCreate(SplashActivity.java:26) 
                                                                    at android.app.Activity.performCreate(Activity.java:5990) 
                                                                    at android.app.Instrumentation.callActivityOnCreate(Instrumentation.java:1106) 
                                                                    at android.app.ActivityThread.performLaunchActivity(ActivityThread.java:2311) 
                                                                    at android.app.ActivityThread.handleLaunchActivity(ActivityThread.java:2420) 
                                                                    at android.app.ActivityThread.access$900(ActivityThread.java:154) 
                                                                    at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1321) 
                                                                    at android.os.Handler.dispatchMessage(Handler.java:102) 
                                                                    at android.os.Looper.loop(Looper.java:135) 
                                                                    at android.app.ActivityThread.main(ActivityThread.java:5294) 
                                                                    at java.lang.reflect.Method.invoke(Native Method) 
                                                                    at java.lang.reflect.Method.invoke(Method.java:372) 
                                                                    at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:904) 
                                                                    at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:699) 
                                                                    Suppressed: java.lang.ClassNotFoundException: android.support.graphics.drawable.VectorDrawableCompat
                                                                    at java.lang.Class.classForName(Native Method)
                                                                    at java.lang.BootClassLoader.findClass(ClassLoader.java:781)
                                                                    at java.lang.BootClassLoader.loadClass(ClassLoader.java:841)
                                                                    at java.lang.ClassLoader.loadClass(ClassLoader.java:504)
                                                                            ... 30 more
                                                                 Caused by: java.lang.NoClassDefFoundError: Class not found using the boot class loader; no stack available

```