After watching a few alphaZero vs stockfish games, I was very intrigued. Clearly, engines can play at a different kind of level, but for the most part the openings seem pretty meta. Nothing extremely heretical jumped out at me in the first few moves. I dont know how much we humans can read into that; best case scenario the last few hundred years have modeled the opening permutations correctly if engines still use them. Still, engines crush humans on a regular basis.

Question
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What would happen if we forced the engine to use a very absurd opening for the first few moves (like moving both rooks out) then have it resume against a human/GM?