broad_id
string | depmap_id
string | ccle_name
string | screen_id
string | upper_limit
int64 | lower_limit
float64 | slope
float64 | r2
float64 | auc
float64 | ec50
float64 | ic50
float64 | name
string | moa
string | target
string | disease.area
string | indication
string | smiles
string | phase
string | passed_str_profiling
bool | row_name
string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BRD-K51313569-001-07-8 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.738708 | -0.176284 | -0.050581 | 0.926767 | 0.000275 | null | palbociclib | CDK inhibitor | CDK4, CDK6 | oncology | breast cancer | CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O, CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O | Launched | true | ACH-000977 |
BRD-K51791723-003-01-7 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.089866 | 1.536992 | 0.632837 | 0.774286 | 0.915868 | 1.041873 | P276-00 | CDK inhibitor | CDK1, CDK4, CDK9 | null | null | CN1CC[C@H]([C@@H]1CO)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl | Phase 2 | true | ACH-000977 |
BRD-K51967704-001-03-6 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.328033 | 12.179878 | 0.790268 | 0.760077 | 0.312729 | 0.341373 | BIIB021 | HSP inhibitor | HSP90AA1 | null | null | COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc23)c1C, COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc23)c1C | Phase 2 | true | ACH-000977 |
BRD-K52313696-001-12-3 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.492984 | 2.536325 | 0.367228 | 0.941485 | 3.341034 | null | tacedinaline | HDAC inhibitor | HDAC1 | null | null | CC(=O)Nc1ccc(cc1)C(=O)Nc1ccccc1N, CC(=O)Nc1ccc(cc1)C(=O)Nc1ccccc1N | Phase 3 | true | ACH-000977 |
BRD-K53414658-001-08-2 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.781636 | 0.207486 | 0.02659 | 0.910934 | 0.545651 | null | tivozanib | VEGFR inhibitor | FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB | null | null | COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC | Phase 3 | true | ACH-000977 |
BRD-K53972329-001-07-0 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.090071 | -0.059499 | -0.069495 | 1 | 1.44202 | null | ruxolitinib | JAK inhibitor | JAK1, JAK2, JAK3, TYK2 | hematologic malignancy, hematology | myelofibrosis, polycythemia vera | N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 | Launched | true | ACH-000977 |
BRD-K54256913-001-08-7 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.748577 | 1.631327 | -0.076653 | 0.891654 | 0.152764 | null | MK-1775 | WEE1 kinase inhibitor | WEE1 | null | null | CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(CC=C)c3=O)cc1 | Phase 2 | true | ACH-000977 |
BRD-K54955827-001-02-2 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.087381 | 0.041324 | -0.033418 | 1 | 0.061992 | null | niraparib | PARP inhibitor | PARP1 | oncology | primary peritoneal cancer (PPC) | NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCCNC1, NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCCNC1 | Launched | true | ACH-000977 |
BRD-K54997624-001-06-0 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.949323 | -3.282359 | -0.176839 | 0.990107 | 0.004053 | null | alpelisib | PI3K inhibitor | PIK3CA, PIK3CB, PIK3CD, PIK3CG | null | null | Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(c1)C(C)(C)C(F)(F)F | Phase 3 | true | ACH-000977 |
BRD-K55187425-236-05-2 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.185095 | 0.509183 | 0.67409 | 0.680031 | 0.271589 | 0.673364 | rigosertib | cell cycle inhibitor, PLK inhibitor | PLK1 | null | null | COc1cc(OC)c(\C=C\S(=O)(=O)Cc2ccc(OC)c(NCC(O)=O)c2)c(OC)c1, COc1cc(OC)c(\C=C\S(=O)(=O)Cc2ccc(OC)c(NCC(O)=O)c2)c(OC)c1, COc1cc(OC)c(\C=C\S(=O)(=O)Cc2ccc(OC)c(NCC(O)=O)c2)c(OC)c1 | Phase 3 | true | ACH-000977 |
BRD-K56343971-001-14-8 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.173218 | -0.060115 | -0.001179 | 1 | 0.641271 | null | vemurafenib | RAF inhibitor | BRAF, RAF1 | oncology | melanoma | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F, CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F, CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F | Launched | true | ACH-000977 |
BRD-K56981171-001-02-8 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.862092 | -1.320608 | 0.027039 | 0.922736 | 0.140462 | null | brigatinib | ALK tyrosine kinase receptor inhibitor, EGFR inhibitor | ALK, EGFR | oncology | non-small cell lung cancer (NSCLC) | COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N1CCN(C)CC1, COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N1CCN(C)CC1 | Launched | true | ACH-000977 |
BRD-K57080016-001-15-9 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.469427 | 1.059217 | 0.482421 | 1 | 0.39219 | null | selumetinib | MEK inhibitor | MAP2K1 | null | null | Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO, Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO | Phase 3 | true | ACH-000977 |
BRD-K57169635-001-04-5 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.806103 | 0.382523 | 0.051362 | 0.916893 | 0.20283 | null | dacomitinib | EGFR inhibitor | EGFR, ERBB2, ERBB4 | null | null | COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1 | Phase 3 | true | ACH-000977 |
BRD-K58435339-001-03-0 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.314686 | 0.682099 | 0.586063 | 0.692953 | 0.134475 | 0.576238 | AT13387 | HSP antagonist | HSP90AA1 | null | null | CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O, CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O | Phase 2 | true | ACH-000977 |
BRD-K58529924-001-01-5 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.148485 | 0.988917 | 0.778992 | 0.791378 | 1.087056 | 1.552381 | ONC201 | AKT inhibitor, MAP kinase inhibitor | TNFSF10 | null | null | Cc1ccccc1CN1C2=NCCN2C2=C(CN(Cc3ccccc3)CC2)C1=O | Phase 2 | true | ACH-000977 |
BRD-K58550667-001-08-7 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.140707 | 6.393923 | 0.795892 | 0.798936 | 0.064511 | 0.067933 | FK-866 | niacinamide phosphoribosyltransferase inhibitor | NAMPT | null | null | O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)\C=C\c1cccnc1 | Phase 2 | true | ACH-000977 |
BRD-K59317601-001-05-5 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.236006 | 2.246505 | 0.839716 | 0.665085 | 0.14204 | 0.18875 | MLN0128 | mTOR inhibitor | MTOR, PIK3CA, PIK3CD, PIK3CG | null | null | CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2c(N)ncnc12 | Phase 2 | true | ACH-000977 |
BRD-K59369769-001-22-9 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.370871 | 0.250875 | 0.143472 | 1 | 3.102446 | null | tozasertib | Aurora kinase inhibitor, Bcr-Abl kinase inhibitor, FLT3 inhibitor, JAK inhibitor | AURKA, AURKB, AURKC, LCK | null | null | CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1, CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 | Phase 2 | true | ACH-000977 |
BRD-K60997853-001-02-3 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.155772 | 1.836285 | 0.844799 | 0.907701 | 3.763377 | 4.611751 | PHA-848125 | CDK inhibitor, growth factor receptor inhibitor | CDK2, CDK4, CDK7, NTRK1 | null | null | CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc-21 | Phase 2 | true | ACH-000977 |
BRD-K61192372-001-08-9 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.996932 | -0.191878 | -0.00839 | 0.998288 | 0.288358 | null | capecitabine | DNA synthesis inhibitor, thymidylate synthase inhibitor | TYMS | oncology | breast cancer, colorectal cancer | CCCCCOC(=O)Nc1nc(=O)n(cc1F)[C@@H]1O[C@H](C)[C@@H](O)[C@H]1O, CCCCCOC(=O)Nc1nc(=O)n(cc1F)[C@@H]1O[C@H](C)[C@@H](O)[C@H]1O, CCCCCOC(=O)Nc1nc(=O)n(cc1F)[C@@H]1O[C@H](C)[C@@H](O)[C@H]1O, CCCCCOC(=O)Nc1nc(=O)n(cc1F)[C@@H]1O[C@H](C)[C@@H](O)[C@H]1O | Launched | true | ACH-000977 |
BRD-K62008436-001-23-9 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.476138 | 4.040081 | 0.544341 | 0.772405 | 0.009219 | 0.019576 | paclitaxel | tubulin polymerization inhibitor | BCL2, MAP2, MAP4, MAPT, NR1I2, TLR4, TUBB, TUBB1 | oncology | ovarian cancer, breast cancer, non-small cell lung cancer (NSCLC) | CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1, CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1, CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1, CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1, CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1 | Launched | true | ACH-000977 |
BRD-K62196610-001-01-6 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.335769 | 3.32993 | 0.349755 | 1 | 0.163283 | null | AVN-944 | inosine monophosphate dehydrogenase inhibitor | IMPDH1, IMPDH2 | null | null | CC[C@H](CC#N)OC(=O)N[C@@H](C)c1cccc(NC(=O)Nc2ccc(-c3cnco3)c(OC)c2)c1 | Phase 2 | true | ACH-000977 |
BRD-K62200014-003-10-5 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.078737 | -0.054108 | -0.021939 | 1 | 8.078635 | null | anagrelide | phosphodiesterase inhibitor | PDE3A | hematology, hematologic malignancy | thrombocythemia, myeloproliferative neoplasms | Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl, Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl, Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl | Launched | true | ACH-000977 |
BRD-K62391742-001-09-7 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.826613 | 0.636388 | 0.169446 | 0.89757 | 0.029604 | null | venetoclax | BCL inhibitor | BCL2 | hematologic malignancy | chronic lymphocytic leukemia (CLL) | CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1, CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1, CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 | Launched | true | ACH-000977 |
BRD-K62627508-001-01-5 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.061778 | 0.696671 | 0.828573 | 0.617717 | 0.205228 | 0.247997 | idasanutlin | MDM inhibitor | MDM2, TP53 | null | null | COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@](C#N)([C@H]1c1cccc(Cl)c1F)c1ccc(Cl)cc1F)C(O)=O | Phase 3 | true | ACH-000977 |
BRD-K63504947-001-14-7 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | -3.767123 | 0.812673 | 0.118805 | 0.975766 | 510.490392 | null | semaxanib | VEGFR inhibitor | FGFR1, FLT1, KDR, KIT, PDGFRA, PDGFRB, RET | null | null | Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1, Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1, Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1, Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1 | Phase 3 | true | ACH-000977 |
BRD-K63712959-001-01-8 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.962709 | -0.00944 | -0.005837 | 0.976117 | 28,660,723,117,756,594,000,000,000 | null | temoporfin | radical formation stimulant | null | oncology | head and neck squamous cell carcinoma (HNSCC) | Oc1cccc(c1)-c1c2CCc(n2)c(-c2cccc(O)c2)c2ccc([nH]2)c(-c2cccc(O)c2)c2ccc(n2)c(-c2cccc(O)c2)c2ccc1[nH]2 | Launched | true | ACH-000977 |
BRD-K64052750-001-22-5 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.005353 | -0.285421 | -0.076861 | 1 | 1.691925 | null | gefitinib | EGFR inhibitor | EGFR | oncology | non-small cell lung cancer (NSCLC) | COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1, COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1, COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1, COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 | Launched | true | ACH-000977 |
BRD-K64881305-001-03-7 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.579011 | 2.565207 | 0.434717 | 0.634543 | 0.002162 | null | ispinesib | kinesin inhibitor | KIF11 | null | null | CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)cc1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1, CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)cc1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1, CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)cc1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1 | Phase 2 | true | ACH-000977 |
BRD-K66175015-001-12-4 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.953225 | 0.890128 | 0.025328 | 0.985958 | 0.590871 | null | afatinib | EGFR inhibitor | EGFR, ERBB2, ERBB4 | oncology | non-small cell lung cancer (NSCLC) | CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1, CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1, CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 | Launched | true | ACH-000977 |
BRD-K67844266-003-01-9 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.08591 | 1.767427 | 0.877812 | 0.432939 | 0.024269 | 0.027001 | pevonedistat | nedd activating enzyme inhibitor | NAE1, UBA3 | null | null | NS(=O)(=O)OC[C@@H]1C[C@H](C[C@@H]1O)n1ccc2c(N[C@H]3CCc4ccccc34)ncnc12 | Phase 2 | true | ACH-000977 |
BRD-K69001009-001-02-8 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.989166 | -0.29934 | 0.00665 | 0.993793 | 0.245988 | null | golvatinib | VEGFR inhibitor | KDR, MET | null | null | CN1CCN(CC1)C1CCN(CC1)C(=O)Nc1cc(Oc2ccc(NC(=O)C3(CC3)C(=O)Nc3ccc(F)cc3)c(F)c2)ccn1 | Phase 2 | true | ACH-000977 |
BRD-K69694239-001-02-2 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | -0.211025 | 0.343902 | 0.820308 | 0.624059 | 1.293864 | 0.464774 | bardoxolone-methyl | nuclear factor erythroid derived, like (NRF2) activator | PPARG, STAT3 | null | null | COC(=O)[C@]12CCC(C)(C)C[C@H]1[C@H]1C(=O)C=C3[C@@]4(C)C=C(C#N)C(=O)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2 | Phase 3 | true | ACH-000977 |
BRD-K69776681-001-03-8 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | -0.065975 | 0.765138 | 0.465353 | 0.798009 | 2.287721 | 1.945612 | volasertib | PLK inhibitor | PLK1 | null | null | CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O, CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O | Phase 3 | true | ACH-000977 |
BRD-K70301465-001-05-9 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.213209 | 0.252127 | 0.074483 | 1 | 0.008699 | null | ibrutinib | Bruton's tyrosine kinase (BTK) inhibitor | BLK, BMX, BTK | hematologic malignancy | chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), Waldenstrom's macroglobulinemia (WM) | Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C, Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C | Launched | true | ACH-000977 |
BRD-K70401845-001-15-7 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.016014 | -0.082588 | -0.003882 | 1 | 0.057729 | null | erlotinib | EGFR inhibitor | EGFR, NR1I2 | oncology | non-small cell lung cancer (NSCLC), pancreatic cancer | COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC, COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC | Launched | true | ACH-000977 |
BRD-K73838513-003-05-5 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.019516 | -0.237743 | -0.079575 | 1 | 249.087683 | null | cinacalcet | calcium channel activator | CASR | endocrinology, nephrology, oncology | hyperparathyroidism, chronic kidney disease (CKD), parathyroid carcinoma, hypercalcemia | C[C@@H](NCCCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12 | Launched | true | ACH-000977 |
BRD-K74514084-003-09-2 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.477127 | 3.849986 | 0.649929 | 0.83355 | 0.455314 | 1.014552 | pazopanib | KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, VEGFR inhibitor | CSF1R, FGF1, FGFR1, FGFR3, FLT1, FLT4, ITK, KDR, KIT, PDGFRA, PDGFRB, SH2B3 | oncology | renal cell carcinoma (RCC), soft tissue sarcoma (STS) | CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1, CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 | Launched | true | ACH-000977 |
BRD-K75009076-001-02-1 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | -0.038037 | 2.876697 | 0.587072 | 0.917744 | 4.8253 | 4.703864 | SCH-900776 | CHK inhibitor | CDK2, CHEK1 | null | null | Cn1cc(cn1)-c1cnn2c(N)c(Br)c(nc12)[C@@H]1CCCNC1, Cn1cc(cn1)-c1cnn2c(N)c(Br)c(nc12)[C@@H]1CCCNC1 | Phase 2 | true | ACH-000977 |
BRD-K76210423-001-01-6 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.181174 | -0.415436 | 0.091056 | 1 | 0.000413 | null | resiquimod | toll-like receptor agonist | TLR7, TLR8 | null | null | CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O, CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O | Phase 3 | true | ACH-000977 |
BRD-K76239644-001-02-6 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.885989 | -0.920206 | 0.031463 | 0.980627 | 0.002426 | null | BMS-690514 | EGFR inhibitor, VEGFR inhibitor | EGFR, ERBB2, FLT3, KDR | null | null | COc1cccc(Nc2ncnn3ccc(CN4CC[C@@H](N)[C@H](O)C4)c23)c1, COc1cccc(Nc2ncnn3ccc(CN4CC[C@@H](N)[C@H](O)C4)c23)c1 | Phase 2 | true | ACH-000977 |
BRD-K76674262-001-03-3 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.113728 | 1.472905 | 0.830989 | 0.534588 | 0.061174 | 0.072888 | homoharringtonine | protein synthesis inhibitor | RPL3 | hematologic malignancy | chronic myeloid leukemia (CML) | COC(=O)C[C@](O)(CCCC(C)(C)O)C(=O)O[C@H]1[C@H]2c3cc4OCOc4cc3CCN3CCC[C@]23C=C1OC | Launched | true | ACH-000977 |
BRD-K76908866-001-07-6 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.558093 | 0.654435 | 0.204479 | 0.897861 | 1.565327 | null | CP-724714 | EGFR inhibitor, protein tyrosine kinase inhibitor | ERBB2 | null | null | COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1 | Phase 2 | true | ACH-000977 |
BRD-K77625799-001-07-7 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.8104 | -4.366104 | 0.119217 | 0.838082 | 2.425715 | null | vandetanib | EGFR inhibitor, RET tyrosine kinase inhibitor, VEGFR inhibitor | EGFR, EPHA1, EPHA10, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, ERBB2, ERBB3, ERBB4, FLT1, FLT4, KDR, PTK6, RET, SRC, TEK, VEGFA | oncology | medullary thyroid cancer (MTC) | COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 | Launched | true | ACH-000977 |
BRD-K78431006-001-15-1 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.866579 | -1.116799 | -0.112991 | 0.976694 | 0.002872 | null | crizotinib | ALK tyrosine kinase receptor inhibitor | ALK, MET | oncology | non-small cell lung cancer (NSCLC) | C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl, C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl, C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl | Launched | true | ACH-000977 |
BRD-K79254416-001-21-8 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.320324 | 1.432975 | 0.295965 | 1 | 0.019263 | null | decitabine | DNA methyltransferase inhibitor | DNMT1, DNMT3A | hematologic malignancy, hematology | myelodysplastic diseases (MDS), anemia, chronic myeloid leukemia (CML) | Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1, Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1, Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1 | Launched | true | ACH-000977 |
BRD-K81016934-001-02-0 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.248802 | 1.957147 | 0.126607 | 1 | 0.022274 | null | INC-280 | c-Met inhibitor | MET | null | null | CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1 | Phase 2 | true | ACH-000977 |
BRD-K81418486-001-44-2 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | -0.299032 | 0.395808 | 0.478947 | 0.625776 | 1.421505 | 0.43489 | vorinostat | HDAC inhibitor | HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC5, HDAC6, HDAC8, HDAC9 | hematologic malignancy | cutaneous T-cell lymphoma (CTCL) | ONC(=O)CCCCCCC(=O)Nc1ccccc1, ONC(=O)CCCCCCC(=O)Nc1ccccc1, ONC(=O)CCCCCCC(=O)Nc1ccccc1 | Launched | true | ACH-000977 |
BRD-K81473043-001-19-5 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.437264 | 1.415898 | 0.749363 | 0.773416 | 0.012586 | 0.054518 | tanespimycin | HSP inhibitor | HSP90AA1 | null | null | CO[C@H]1C[C@H](C)CC2=C(NCC=C)C(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O, CO[C@H]1C[C@H](C)CC2=C(NCC=C)C(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O | Phase 3 | true | ACH-000977 |
BRD-K82135108-001-04-3 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.470373 | 1.224673 | 0.578178 | 0.645417 | 0.014838 | 0.14911 | elesclomol | oxidative stress inducer | HSPA1A | null | null | CN(NC(=O)CC(=O)NN(C)C(=S)c1ccccc1)C(=S)c1ccccc1 | Phase 3 | true | ACH-000977 |
BRD-K82746043-001-19-3 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.427184 | 6.290716 | 0.28 | 0.889121 | 1.528164 | 2.075788 | navitoclax | BCL inhibitor | BCL2, BCL2L1, BCL2L2 | null | null | CC1(C)CCC(=C(CN2CCN(CC2)c2ccc(cc2)C(=O)NS(=O)(=O)c2ccc(N[C@H](CCN3CCOCC3)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)C1)c1ccc(Cl)cc1, CC1(C)CCC(=C(CN2CCN(CC2)c2ccc(cc2)C(=O)NS(=O)(=O)c2ccc(N[C@H](CCN3CCOCC3)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)C1)c1ccc(Cl)cc1 | Phase 2 | true | ACH-000977 |
BRD-K82818427-001-04-8 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.965021 | 0.02451 | 0.00115 | 0.982095 | 0.011219 | null | batimastat | matrix metalloprotease inhibitor | ADAM28, ADAMTS5, MMP12, MMP16, MMP2, MMP8 | null | null | CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)[C@H](CSc1cccs1)C(=O)NO, CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)[C@H](CSc1cccs1)C(=O)NO | Phase 3 | true | ACH-000977 |
BRD-K83029223-001-01-3 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.633784 | 12.093612 | 0.475966 | 0.764552 | 0.001219 | null | litronesib | kinesin-like spindle protein inhibitor | KIF11 | null | null | CCNCCS(=O)(=O)NC[C@]1(SC(NC(=O)C(C)(C)C)=NN1C(=O)C(C)(C)C)c1ccccc1 | Phase 2 | true | ACH-000977 |
BRD-K83988098-001-02-0 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.013098 | 0.451323 | 0.537089 | 0.720975 | 0.01943 | 0.020607 | alvespimycin | HSP inhibitor | HSP90AA1 | null | null | CO[C@H]1C[C@H](C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O, CO[C@H]1C[C@H](C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O | Phase 2 | true | ACH-000977 |
BRD-K85402309-043-01-9 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.796224 | -5.145393 | 0.248067 | 0.914246 | 0.036221 | null | dovitinib | EGFR inhibitor, FGFR inhibitor, FLT3 inhibitor, PDGFR tyrosine kinase receptor inhibitor, VEGFR inhibitor | CSF1R, EGFR, FGFR1, FGFR2, FGFR3, FLT1, FLT3, FLT4, INSR, KDR, KIT, PDGFRA, PDGFRB | null | null | CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O, CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O, CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O, CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O, CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O, CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O | Phase 3 | true | ACH-000977 |
BRD-K85606544-001-09-1 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.751914 | -3.234845 | -0.025083 | 0.943411 | 0.00558 | null | neratinib | EGFR inhibitor | EGFR, ERBB2, KDR | null | null | CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C | Phase 3 | true | ACH-000977 |
BRD-K86118762-001-01-8 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.746426 | -0.841646 | 0.127736 | 0.949253 | 0.003293 | null | linsitinib | IGF-1 inhibitor | IGF1R, INSR, INSRR | null | null | C[C@@]1(O)C[C@@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12, C[C@@]1(O)C[C@@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12 | Phase 3 | true | ACH-000977 |
BRD-K86972824-001-01-4 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.692652 | 2.215845 | 0.221306 | 0.939155 | 1.47377 | null | oltipraz | nuclear factor erythroid derived, like (NRF2) activator | ANG | null | null | Cc1c(ssc1=S)-c1cnccn1, Cc1c(ssc1=S)-c1cnccn1 | Phase 3 | true | ACH-000977 |
BRD-K87737963-001-06-0 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.719807 | 0.148527 | -0.034572 | 0.926478 | 108.095103 | null | cyt387 | null | JAK1, JAK2, JAK3 | null | null | O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1, O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 | Phase 3 | true | ACH-000977 |
BRD-K87782578-001-01-4 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.957049 | -0.881577 | 0.05768 | 0.982703 | 0.02949 | null | AVL-292 | Bruton's tyrosine kinase (BTK) inhibitor | BTK, YES1 | null | null | COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1 | Phase 2 | true | ACH-000977 |
BRD-K87909389-003-03-4 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.398424 | 2.792547 | 0.772218 | 0.697675 | 0.07619 | 0.134824 | alvocidib | CDK inhibitor | CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, EGFR, PYGM | null | null | CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl, CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl | Phase 2 | true | ACH-000977 |
BRD-K88510285-001-17-8 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.094418 | 2.360649 | 0.839239 | 0.54145 | 0.018387 | 0.020092 | bortezomib | NFkB pathway inhibitor, proteasome inhibitor | PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB10, PSMB11, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9, PSMD1, PSMD2, RELA | hematologic malignancy | multiple myeloma, mantle cell lymphoma (MCL) | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O, CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O, CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O, CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O, CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O | Launched | true | ACH-000977 |
BRD-K89014967-001-04-3 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.972242 | -1.522776 | -0.615714 | 0.991059 | 0.013819 | null | AS-703026 | MEK inhibitor | MAP2K1, MAP2K2 | null | null | OC[C@@H](O)CNC(=O)c1ccncc1Nc1ccc(I)cc1F | Phase 2 | true | ACH-000977 |
BRD-K92441787-001-04-1 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.752259 | -0.040254 | -0.005491 | 0.851798 | 1,586.131512 | null | bexarotene | retinoid receptor agonist | RXRA, RXRB, RXRG | hematologic malignancy | cutaneous T-cell lymphoma (CTCL) | Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C | Launched | true | ACH-000977 |
BRD-K92723993-001-17-4 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.797175 | 0.531397 | 0.066094 | 0.906619 | 0.122239 | null | imatinib | Bcr-Abl kinase inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor | ABL1, CSF1R, DDR1, KIT, NTRK1, PDGFRA, PDGFRB, RET | hematologic malignancy, oncology | chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL), myelodysplastic diseases (MDS), aggressive systemic mastocytosis (ASM), hypereosinophilic syndrome (HES), chronic eosinophilic leukemia (CEL), dermatofibrosarcoma protuberans (DFSP), gastrointestinal stromal tumors (GIST) | CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1, CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1, CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 | Launched | true | ACH-000977 |
BRD-K95142244-001-01-5 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.097526 | 0.739622 | 0.073489 | 1 | 0.177135 | null | talazoparib | PARP inhibitor | PARP2 | null | null | Cn1ncnc1[C@@H]1[C@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1 | Phase 3 | true | ACH-000977 |
BRD-K96123349-236-02-8 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.908163 | 0.593911 | 0.468388 | 1 | 1.126433 | null | brequinar | dihydroorotate dehydrogenase inhibitor | DHODH | null | null | Cc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F | Phase 2 | true | ACH-000977 |
BRD-K98572433-001-02-9 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.969429 | 0.025834 | -0.001576 | 0.985129 | 0.639761 | null | AZD8931 | EGFR inhibitor | EGFR, ERBB2, ERBB3 | null | null | CNC(=O)CN1CCC(CC1)Oc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC | Phase 2 | true | ACH-000977 |
BRD-K99113996-001-02-0 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.132339 | 0.650637 | 0.599788 | 0.811579 | 1.885322 | 3.024145 | AZD2014 | mTOR inhibitor | MTOR | null | null | CNC(=O)c1cccc(c1)-c1ccc2c(nc(nc2n1)N1CCOC[C@@H]1C)N1CCOC[C@@H]1C | Phase 2 | true | ACH-000977 |
BRD-K99616396-001-05-1 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 0.925678 | -0.056928 | -0.005439 | 0.945807 | 3,111,536.341751 | null | motesanib | KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, VEGFR inhibitor | FLT1, FLT4, KDR, KIT | null | null | CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12, CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12, CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12, CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12, CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 | Phase 3 | true | ACH-000977 |
BRD-K99749624-001-07-0 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.155981 | -0.054918 | -0.136087 | 1 | 0.528021 | null | linifanib | PDGFR tyrosine kinase receptor inhibitor, VEGFR inhibitor | CSF1, CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RET, TEK | null | null | Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 | Phase 3 | true | ACH-000977 |
BRD-M97302542-001-04-4 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | MTS010 | 1 | 1.127051 | -0.184098 | -0.007319 | 1 | 3.678657 | null | dichloroacetate | pyruvate dehydrogenase kinase inhibitor | PDK1 | null | null | [Na].OC(=O)C(Cl)Cl, [Na].OC(=O)C(Cl)Cl | Phase 3 | true | ACH-000977 |
BRD-A25234499-001-19-1 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 1.334834 | -0.058492 | -0.043172 | 1 | 0.029786 | null | aminoglutethimide | glucocorticoid receptor antagonist | CYP11A1, CYP19A1 | endocrinology, oncology | Cushing's syndrome, breast cancer | CCC1(CCC(=O)NC1=O)c1ccc(N)cc1, CCC1(CCC(=O)NC1=O)c1ccc(N)cc1, CCC1(CCC(=O)NC1=O)c1ccc(N)cc1 | Launched | true | ACH-000978 |
BRD-A70858459-001-01-7 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 1.135701 | -0.073606 | -0.089666 | 1 | 6.312141 | null | estramustine | DNA alkylating agent | ESR1, ESR2, MAP1A, MAP2 | oncology | prostate cancer | C[C@]12CCC3C(CCc4cc(OC(=O)N(CCCl)CCCl)ccc34)C1CC[C@@H]2O | Launched | true | ACH-000978 |
BRD-A74914197-001-02-9 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 1.705649 | 3.499663 | 0.10216 | 1 | 0.040772 | null | pralatrexate | dihydrofolate reductase inhibitor | DHFR, TYMS | hematologic malignancy | peripheral T-cell lymphoma (PTCL) | Nc1nc(N)c2nc(CC(CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1 | Launched | true | ACH-000978 |
BRD-K02113016-001-19-6 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 0.735855 | -0.902594 | 0.143848 | 0.884756 | 0.041397 | null | olaparib | PARP inhibitor | PARP1, PARP2 | oncology | ovarian cancer | Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCN(CC1)C(=O)C1CC1, Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCN(CC1)C(=O)C1CC1 | Launched | true | ACH-000978 |
BRD-K02130563-001-11-4 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 2.051796 | 10.494495 | 0.225016 | 1 | 0.022366 | null | panobinostat | HDAC inhibitor | HDAC1, HDAC2, HDAC3, HDAC4, HDAC6, HDAC7, HDAC8, HDAC9 | hematologic malignancy | multiple myeloma | Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1, Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1, Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1, Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1 | Launched | true | ACH-000978 |
BRD-K03390685-001-01-7 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 2.710852 | 0.454343 | 0.347707 | 1 | 0.392664 | null | cobimetinib | MEK inhibitor | null | oncology | melanoma | OC1(CN(C1)C(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)[C@@H]1CCCCN1 | Launched | true | ACH-000978 |
BRD-K03406345-001-21-1 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 1.389181 | 0.390216 | 0.136516 | 1 | 0.44881 | null | azacitidine | DNA methyltransferase inhibitor | DNMT1, DNMT3A | hematologic malignancy, hematology | myelodysplastic diseases (MDS), anemia, chronic myelomonocytic leukemia (CMMoL) | Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1 | Launched | true | ACH-000978 |
BRD-K03449891-001-08-6 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 0.981941 | 0.156127 | -0.024882 | 0.987467 | 0.000173 | null | foretinib | VEGFR inhibitor | FLT1, FLT4, KDR, MET | null | null | COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 | Phase 2 | true | ACH-000978 |
BRD-K03765900-001-01-9 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 0.733957 | -0.486126 | -0.122722 | 0.858674 | 0.054824 | null | XL-647 | EGFR inhibitor, VEGFR inhibitor | EGFR, EPHB4, ERBB2, FLT4, KDR | null | null | COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@H]1C[C@H]2CN(C)C[C@H]2C1 | Phase 3 | true | ACH-000978 |
BRD-K05804044-001-18-5 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 1.701724 | 0.595755 | 0.158553 | 1 | 18.260847 | null | AZ-628 | RAF inhibitor | BRAF, RAF1 | null | null | Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1Nc1ccc2ncn(C)c(=O)c2c1, Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1Nc1ccc2ncn(C)c(=O)c2c1, Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1Nc1ccc2ncn(C)c(=O)c2c1, Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1Nc1ccc2ncn(C)c(=O)c2c1 | Preclinical | true | ACH-000978 |
BRD-K06814349-304-02-7 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 2.271127 | 9.106193 | 0.865981 | 1 | 1.202421 | null | fosbretabulin | tubulin polymerization inhibitor, VE-cadherin antagonist | CDH5 | null | null | COc1ccc(C=Cc2cc(OC)c(OC)c(OC)c2)cc1OP(O)(O)=O, COc1ccc(cc1OP(O)(O)=O)\C=C/c1cc(OC)c(OC)c(OC)c1, COc1ccc(cc1OP(O)(O)=O)\C=C/c1cc(OC)c(OC)c(OC)c1, COc1ccc(C=Cc2cc(OC)c(OC)c(OC)c2)cc1OP(O)(O)=O | Phase 3 | true | ACH-000978 |
BRD-K08109215-001-06-4 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 0.926266 | -5.299209 | -0.013854 | 0.933052 | 4.100716 | null | I-BET-762 | bromodomain inhibitor | BRD2, BRD3, BRD4 | null | null | CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12 | Phase 2 | true | ACH-000978 |
BRD-K08542803-001-02-3 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 0.098536 | 0.389778 | 0.420945 | 0.625453 | 0.239295 | 0.420235 | gambogic-acid | caspase activator | BCL2 | null | null | CC(C)=CCC[C@@]1(C)Oc2c(CC=C(C)C)c3O[C@@]45[C@H]6C[C@@H](C=C4C(=O)c3c(O)c2C=C1)C(=O)[C@]5(C\C=C(\C)C(O)=O)OC6(C)C, CC(C)=CCC[C@@]1(C)Oc2c(CC=C(C)C)c3O[C@@]45[C@H]6C[C@@H](C=C4C(=O)c3c(O)c2C=C1)C(=O)[C@]5(C\C=C(\C)C(O)=O)OC6(C)C, CC(C)=CCC[C@@]1(C)Oc2c(CC=C(C)C)c3O[C@@]45[C@H]6C[C@@H](C=C4C(=O)c3c(O)c2C=C1)C(=O)[C@]5(C\C=C(\C)C(O)=O)OC6(C)C | Phase 2 | true | ACH-000978 |
BRD-K08547377-001-04-4 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 3.30262 | 18.566647 | 0.744723 | 1 | 0.042121 | null | irinotecan | topoisomerase inhibitor | TOP1, TOP1MT | oncology | colorectal cancer | CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12, CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12, CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12, CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12, CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12, CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12, CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12 | Launched | true | ACH-000978 |
BRD-K08703257-001-13-9 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 1.121892 | -0.116215 | -0.061786 | 1 | 0.886227 | null | 3-amino-benzamide | PARP inhibitor | PARP1 | null | null | NC(=O)c1cccc(N)c1, NC(=O)c1cccc(N)c1 | Phase 2 | true | ACH-000978 |
BRD-K08799216-001-05-3 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 3.360638 | 1.609746 | 0.930557 | 1 | 0.468118 | null | pelitinib | EGFR inhibitor | EGFR | null | null | CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C | Phase 2 | true | ACH-000978 |
BRD-K09951645-001-11-8 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 1.007732 | -0.412313 | -0.075436 | 1 | 4.530362 | null | dabrafenib | RAF inhibitor | BRAF, LIMK1, NEK11, RAF1, SIK1 | oncology | melanoma | CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F, CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F, CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F | Launched | true | ACH-000978 |
BRD-K11267252-001-05-1 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 1.089816 | 0.183755 | -0.022378 | 1 | 0.025002 | null | alectinib | ALK tyrosine kinase receptor inhibitor | ALK, MET | oncology | non-small cell lung cancer (NSCLC) | CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N1CCOCC1, CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N1CCOCC1 | Launched | true | ACH-000978 |
BRD-K11630072-001-13-2 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 1.458926 | 9.579052 | 0.33536 | 1 | 6.033121 | null | carmofur | thymidylate synthase inhibitor | TYMS | oncology | breast cancer, colorectal cancer | CCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=O, CCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=O, CCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=O | Launched | true | ACH-000978 |
BRD-K12184916-001-19-6 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 0.73548 | 0.516823 | -0.103382 | 0.834079 | 0.017415 | null | NVP-BEZ235 | mTOR inhibitor, PI3K inhibitor | ATR, MTOR, PIK3CA, PIK3CD, PIK3CG | null | null | Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1, Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1 | Phase 2 | true | ACH-000978 |
BRD-K12343256-001-14-7 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 2.421003 | 0.499623 | 0.410677 | 1 | 0.386706 | null | trametinib | MEK inhibitor | MAP2K1, MAP2K2 | oncology | melanoma | CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O, CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O, CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O, CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O | Launched | true | ACH-000978 |
BRD-K13049116-001-04-0 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 1.404013 | 0.473081 | -0.236849 | 1 | 0.685899 | null | BMS-754807 | IGF-1 inhibitor | AKT1, IGF1R | null | null | C[C@]1(CCCN1c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ccc(F)nc1, C[C@]1(CCCN1c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ccc(F)nc1, C[C@]1(CCCN1c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ccc(F)nc1 | Phase 2 | true | ACH-000978 |
BRD-K13390322-001-06-3 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 0.05017 | 0.42174 | 0.592452 | 0.725471 | 1.261421 | 1.620863 | AT-7519 | CDK inhibitor | CDK1, CDK2, CDK4, CDK5, CDK6, CDK9 | null | null | Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1 | Phase 2 | true | ACH-000978 |
BRD-K13514097-001-04-6 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 1.393939 | -0.089739 | -0.095171 | 1 | 195.546145 | null | everolimus | mTOR inhibitor | MTOR | oncology, neurology/psychiatry, genetics, urology | breast cancer, neuroendocrine tumors of pancreatic origin (PNET), renal cell carcinoma (RCC), subependymal giant cell astrocytoma (SEGA), tuberous sclerosis complex (TSC), renal angiomyolipoma | CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1OCCO, CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1OCCO | Launched | true | ACH-000978 |
BRD-K13662825-001-07-5 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 0.334729 | 0.341012 | 0.100857 | 0.675159 | 0.023122 | 0.594129 | dinaciclib | CDK inhibitor | CDK1, CDK2, CDK5, CDK9 | null | null | CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO | Phase 3 | true | ACH-000978 |
BRD-K14109347-001-03-4 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 0.800483 | -1.568619 | -0.05065 | 0.962813 | 0.003582 | null | LY2603618 | CHK inhibitor | CHEK1 | null | null | Cc1cnc(NC(=O)Nc2cc(Br)c(C)cc2OC[C@@H]2CNCCO2)cn1, Cc1cnc(NC(=O)Nc2cc(Br)c(C)cc2OC[C@@H]2CNCCO2)cn1 | Phase 2 | true | ACH-000978 |
BRD-K15179879-001-03-2 | ACH-000978 | EN_ENDOMETRIUM | MTS010 | 1 | 0.443116 | 0.425313 | 0.456043 | 0.675022 | 0.027224 | 4.512898 | carfilzomib | proteasome inhibitor | PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB10, PSMB11, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 | hematologic malignancy | multiple myeloma | CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 | Launched | true | ACH-000978 |
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