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A Gay Accommodation in Leicestershire is usually hard to discover if you don't know where to begin, but you are able to begin your search online of look via the local paper. If you are seeking gay accommodation in the area then you can start your search online or you are able to ask local people in the area who may be able to better help you. You can discover a good Gay Accommodation in Leicestershire, but it may be tough with out knowing where to start, Menplace.com features a full list in the items beneath to help you get started on your search.
Finding high quality gay accommodation is essential to happy stay where ever you go and you can actually always begin your search online for the best locations in your area. Not everywhere is going to be the best for gay accommodation so you might wish to look at a place in person before agreeing to any contracts or stays. If you're looking for gay accommodation that is high quality, than you need to search for places with the best reviews by its previous customers.
Holding an estimated population of 33.720, Wigston is one of the most important cities in Leicestershire. Check all of the Gay Place in Wigston and its surrounding area.
It's difficult to visit Leicestershire without having dropping by Loughborough (with 59.317 residents). Currently Menkarta is showing you all the Gay Place in Loughborough along with the closest gay places situated in its vicinity.
During your visit to Hinckley (Leicestershire), or even if you are a local. Menkarta helps you to locate your closest Gay Meeting Place in Hinckley. | 2019-04-22T22:24:23 | https://www.menkarta.co.uk/gay-accommodation-united-kingdom/leicestershire-i2/ |
Dura Supreme has been crafting beautiful kitchen cabinetry for over 60 years! Our reputation for excellence in craftsmanship and quality, and our beautiful, luxurious finishes are appreciated by homeowners across the USA. We have many dedicated and experienced employees who have proudly made their careers at Dura Supreme for 10, 20, 30 and even 40 years! That kind of experience translates into the quality that has made Dura Supreme a well-known name for beautiful kitchen cabinets.
This section of the website is full of helpful and practical information about our product lines, quality, and construction details. Our photo gallery is full of ideas for your new kitchen.
Be sure to visit one of our Dura Supreme Showrooms where you can consult with a professional kitchen designer and see cabinet samples and displays. Your kitchen designer can guide you through our product lines and design choices so that you are confident in the value and quality available with Dura Supreme cabinetry. Whether you are beginning a kitchen remodel or building a new home, Dura Supreme kitchen cabinetry is a beautiful choice and a wise investment.
For information about our many design choices for kitchen cabinetry, be sure to visit our Styling Guide section. | 2019-04-24T00:30:40 | https://www.durasupreme.com/products/kitchen-cabinets |
Our vision of the future we are creating together: We are a community of friends who work, share, learn, grow and play together. As time passes, we sense our neighbors becoming our extended family. Our neighborhood feels like home to all who want to live and visit here. It is a comfortable space that supports both individual expression and shared experiences.
Touchstone is a neighborhood of 34 households on six acres in Scio Township. It is a community created and sustained by its residents with the intention of sharing the joys and challenges of life and appreciating each individual.
All content licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. | 2019-04-25T11:59:16 | http://www.touchstonecohousing.org/mission-and-values/ |
September 29 - Mark Britton returns for a follow up visit. Mark and Sylvia will be discussing the medicinal and food uses for common weeds. It will be helpful to listen to the first program before tuning in to this one. | 2019-04-20T08:45:53 | http://www.blogtalkradio.com/doctorprepper/2011/09/30/21st-century-homekeeper |
AX is pleased to announce that Lani Smith has signed her first professional contract with Vasteras BK30 of the Swedish First Division after attending the Ft. Lauderdale combine in December of 2015.
For Smith, the offer came as a surprise, as she had just graduated from the University of Akron three months prior.
“It was pretty unexpected how quickly everything happened. I graduated college in December, and two months later I am signed with a professional team. I am anxious to get over there and start working with the team,” Smith said.
Smith was a standout at Akron, earning All-Conference honors in both her seasons with the Zips after transferring from the University of South Carolina in 2012.
AX is thrilled to help connect young players to professional teams around the world through their combines and training sessions, and Smith was no exception.
“I would definitely recommend them to other players looking to play in Europe. They are honest, organized, and very connected to European soccer. Even though I went to this combine to showcase my abilities, I feel that I learned a lot from the coaches, and built great connections,” Smith said.
The 24 year old heard about AX from none other than her roommate and fellow Akron Zip, who attended an AX event in San Diego. After that conversation, Smith had heard enough, and decided to make the trip to Ft. Lauderdale to chase her dreams.
“She motivated me to go to the Fort Lauderdale combine with her. They are the first and only agency I heard about and made contact with; thankfully, they did such a great job that I didn’t need anything else,” she said.
Smith said she felt she was able to trust and gain continuity with everyone involved in the combine, including her coach.
“What I liked most about it was we were put into teams and assigned one coach which we stayed with the whole day. That definitely helped me feel more comfortable and allowed us to work together to showcase ourselves instead of everyone trying to do it individually,” Smith added.
Luckily for her, the team she has signed with has plenty of AX alumni on their squad already. The Scandinavian side signed Tori Christ in 2015 and Lauren Prott earlier this year.
The winner of Sweden’s First Division also gets the opportunity to play in the Women’s Europa League, which pits the best teams in European women’s soccer against each other.
“I’m very excited to get the opportunity to experience Sweden and everything it has to offer. I have never been to Europe, so having the chance to live there for eight months is very exciting, especially in a country I have heard so many good things about and for such a well-established club. Being able to play in a country that appreciates soccer so much is very exciting,” Smith said.
Vasteras BK30 opens its season on April 10 with an exhibition against Bollstanas SK. | 2019-04-18T18:49:50 | http://blog.axsoccertours.com/lani-smith-signs-with-vasteras-bk30-in-sweden/ |
oneye is one of the most genius ways to access your data from everywhere with anything you have around.
The oneye software is an open source cloud software for your own server. It can be accessed from just everywhere with the browser of your choice and it does not provide your data only, but gives you the possibility to work with them in a desktop-like environment – all inside your browser.
Now take a look at our Screenshots section and try oneye out using a Demo system.
Finally you can Download oneye and get free community support in the Forums.
Do you like oneye? Think about Donating just one or more dollars.
oneye is released under the terms of the Affero General Public License, version 3 and additional conditions. The following list sums up the most important points of the licensing.
oneye is released as open source software. You can use and modify it for free.
Software written for oneye can have any license, but need to be released to the oneye community or privately to the oneye team via [email protected].
Modifications of the oneye system components need to be released to the oneye team.
Creators of closed source software are asked to donate. | 2019-04-25T22:00:08 | https://oneye-project.org/ |
There is so much to be done as a self-publisher, and while I wouldn’t dare pretend that I can tell everyone how they should do things, I’m more than happy to share with you the steps I took ahead of my first book’s release.
Hire an editor — There are two things that often separate traditionally published novels versus the self-published ones — cover design and editing. That said, if you don’t want your book to be seen as amateurish, then make sure you get those two things right. I’ll talk about cover design further down this list, but as for the professional editing, once you feel you have done your best in getting your novel to its final form, hire a reputable editor and send your manuscript to them. (I’ve got an entire post about why everyone needs to hire a copy editor—indie or traditional. Click here to read it.) Once it’s out of your hands for 4-6 weeks, you can get started on the business end of self-publishing.
Set up a publishing company — Hopefully, you’ve already decided on whether or not you want to set up your own publishing company. I did, and I have set up a website for it — Seaport Publishing. If you go this route, you’ll need to decide on whether or not you want to set up a formal business structure — either as a sole proprietor, LLC, or something more complex. I read in the 2014 Guide to Self-Publishing that for most self-published authors, a sole proprietorship is the business model of choice. I’m not a CPA or a tax professional, so I can dispense no advice in this regard. I can only tell you that if you haven’t already, you need to ask yourself if you plan to take this writing business seriously. If you do, then you should manage it seriously. Have a separate account set up especially for your writing expenses and revenue, and keep records of everything so that when tax time comes around, you’ll be ready to report on your earnings (if you have any) and your expenses — things like that receipt for your Scrivener software, that fountain pen and those composition books, your subscription to Writer’s Digest, or your domain name and website hosting.
Establish your Print-on-Demand (POD) and eBook accounts — This is a great time to set up your accounts with Amazon’s CreateSpace, Ingram’s IngramSpark, and Barnes & Noble’s NookPress. I know there are lots of other self-publishing platforms out there, but those are the three big ones. In terms of print, I use CreateSpace only for selling books via Amazon.com and IngramSpark for everything else. Here’s a great article that makes the case for why and how you should use those two services together. As for ebooks, I’ll be sticking with KDP for now.
Buy your ISBNs and barcodes — There’s a lot to know here. In fact, maybe I’ll write a post about this in the near future. For the sake of keeping this article succinct, however, I’ll just say that since I want to be sure I can have my print book available anywhere that wants to carry it, I have purchased a set of 10 ISBNs and just one barcode (for now) from Bowker. Bowker is the ISBN-assigning agency for the United States. If you live in a different country, you’ll need to do an online search for which agency you should use. Just to clarify, I’ll only need one ISBN and barcode for my novel, unless I decide to release it in both paperback and hardcover formats, in which case I’ll need to have a unique ISBN and barcode for each format. I do not recommend using CreateSpace to get your ISBN, even though they offer that service. Unless you want Amazon’s CreateSpace to be the publisher-of-record for your book, you’ll want to buy your own ISBNs. You can get them in bulk from Bowker.
Design your cover — This part can be tricky. Both CreateSpace and IngramSpark offer template-based cover designing, but if you want a wrap around cover (like the one I’ll be using for The Smuggler’s Gambit), you’ll need to know how many pages your finished book will be before you can download a cover design template. In the short term, if you already know what you want the front cover to look like, and you’re not very comfortable using Photoshop, you can use a free service like Canva to build it.
Build your platform — Really, truly, you should have already been working on this while you’ve been in the process of writing your novel, but at this point, you need to amp up your platform-building activity. While your manuscript is with your editor, now might be a good time to talk to local booksellers about stocking your book. Maybe a good way to approach them is with a nice-quality printout of your book’s cover. Ask them if they think the design is an attention-grabbing one. This is also a good time to get your author page set up on Facebook and decide on the other social media sites that you think you might want to plug into.
Decide on a tentative release date — By the time you’ve gotten all of those things done, you may very well have your manuscript back from your editor. Depending on the changes that he suggests, you still have more work to do. Once you’ve integrated your editor’s changes into your final manuscript, it will be time to decide on a release date. Spring is traditionally a big time for book releases, but depending on the subject matter of your novel, you may actually want to time your book’s release differently. For instance, my first novel takes place in May of 1765, and since it was due to be released in 2015 — exactly 250 years after the story’s events — I wanted to be sure my book was out far enough ahead of May to gain some traction with readers.
Once you’ve gotten all of these steps taken care of, you’ll hopefully be ready to dive into publishing.
You have worked so hard on dreaming up your story, and writing it, and editing it, and refining it. Now isn’t the time to get exhausted and do things half-way. Whether or not your independently-published book is as successful as it can be depends entirely on you. Part of the beauty of self-publishing — total control — can also be the beast of self-publishing. If you get impatient and try to do things in a hurry, or without doing your homework, you’re only going to end up cheating yourself of what could otherwise be a more successful venture. On the other hand, if you give your novel’s publication all of the care and attention it deserves — ensuring that it’s the very best it can possibly be — then you can know that, by God’s grace, you did that. An agent didn’t do that for you. A big, traditional publishing house didn’t do that for you. You did. | 2019-04-23T04:26:58 | https://www.sarawhitford.com/how-to-get-ready-to-independently-publish-your-novel/ |
Wait, Did Trump’s EPA Just Do Its Job for a Change?
Look at that beaut. Volvo’s all-electric truck, the Volvo FL Electric.
The Environmental Protection Agency announced Tuesday it plans to better regulate the pollutants spewing out of heavy-duty trucks. Yes, this is the same EPA that wants to keep coal power plants alive, plans to scrap regulations on mercury emissions, and does not care about fuel efficiency.
Could Trump’s EPA actually be doing something helpful for our planet and health for a change? Maybe! But let’s not get too ahead of ourselves here.
The proposed “Cleaner Truck Initiative” seeks to decrease nitrogen oxide (NOx) emissions from heavy-duty trucks, which can worsen or help spur asthma and other respiratory issues when inhaled regularly. These gases can also help contribute to the formation of smog. Nitrous oxide, a form of nitrogen oxide, also warms the planet, making up 6 percent of U.S. greenhouse gas emissions.
The proposal to tighten NOx emissions standards, which have not been updated since 2001, began under former President Barack Obama. And while it’s a rare sign of progress for Trump’s EPA to push forward with an Obama-era regulation, this one still doesn’t go far enough, said Mustafa Ali, former environmental justice administrator at the EPA.
The U.S. emitted 14.1 million tons of NOx in 2011. In 2014, roughly half of those emissions were from vehicles. Most of those come from vehicles running on diesel like heavy duty trucks, according to a 2017 EPA document. If we were really serious about decreasing this (and all other) truck pollution, it’d mean going electric.
Obviously, this is easier said than done: Implementing a nationwide ban on fossil fuel trucks would require a complete infrastructure makeover that’d switch out gas stations for charging stations to support these vehicles. And of course, charging stations would need to run on renewable energy for the electric vehicles to be better for the environment. If the EPA even took the miraculous step of mandating zero truck emissions, industry officials and likely even state governments would be pissed and challenge the proposal in court.
Nothing about it would be easy.
But it wouldn’t be impossible, and radical change is becoming increasingly necessary as the threat of catastrophic climate change looms. And other countries are stepping up. Spain, for example, proposed Tuesday to remove all gas-powered cars from its roads by 2040. Other European countries and cities are also moving forward with fossil fuel car bans. If the U.S. is going to update these standards, why not go all the way?
He’s right: In 2017, University of Washington researchers published findings on nitrogen dioxide emissions nationwide, which largely come from transportation, and found that people of color experienced higher exposure to this pollutant between 2000 to 2010. That’s why advocacy organizations like the Moving Forward Network have been urging the EPA to implement zero-emissions technologies in heavy-duty trucks since at least 2016.
The communities that live day to day exposed to pollution from truck traffic are sure to welcome any relief. The EPA could always, however, go a step further to ensure no communities need to bear the burden of unhealthy air. | 2019-04-25T08:15:17 | https://earther.gizmodo.com/wait-did-trump-s-epa-just-do-its-job-for-a-change-1830439364 |
Retinoic (ret-tin-o-ick) acid interferes with the growth and development of cells. It is related to vitamin A.
Retinoic acid is given by mouth. It comes in capsule form and should be swallowed whole with food or milk. It should be given at regular times to keep a steady level in the bloodstream. Your child should be awake and alert when taking any medicine.
Soften the capsule in warm water. Then your child can bite or chew it.
Open the capsule in a clear plastic bag. Mix the medicine with a small amount of higher-fat food such as ice cream or peanut butter. Give it immediately, and make sure your child takes all of the mixture.
If using a feeding tube, soften the capsule in warm whole milk. Puncture or cut open the capsule and squeeze the liquid into the milk. Draw the mixture into an oral syringe and give the mixture through the feeding tube. Flush the feeding tube well with a minimum of 30ml of milk or tube feed.
Note: The medicine breaks down quickly if exposed to light and air, so it must be given right away after preparing it.
Give it with food or milk, especially higher-fat foods, to increase absorption.
Do not take vitamin supplements that contain vitamin A, because they may increase the side effects of retinoic acid.
Tell your doctor if your child is on tetracycline. Check with the doctor, nurse practitioner, or pharmacist before giving any other prescription or non-prescription medicines, herbs, or vitamins.
If a dose is missed, please call the clinic.
This medicine can cause birth defects. Because of this, there are special safeguards. No refills are allowed, so you will need a new prescription every month. You must pick up the prescription within 7 days after it was filled.
For females of childbearing age, your provider will register you in the iPledge program.
Each month you will have a pregnancy test at the clinic. If it is negative, your provider will call the iPledge number, and will give you a new prescription.
confirm that you have been counseled about the medicine.
confirm that you are using 2 forms of birth control.
confirm that you have had a monthly pregnancy test.
Before filling the prescription, the pharmacy will call iPledge to get approval.
All caregivers, especially women who are or could become pregnant, should wear gloves when handling retinoic acid. Also wear gloves when handling urine, stool, and vomit during chemotherapy and for 48 hours afterward. Urine, stool, and vomit can be safely disposed of in septic tanks and the sewer system.
To prevent sunburn, wear sunscreen and protective clothing when outdoors. Do not use sun lamps and tanning beds.
Use moisturizers for dry skin and lips.
Check the label for the expiration date. Outdated medicines should be returned to your pharmacy or the clinic for disposal. Do not flush them down the toilet or throw them in the garbage.
Store all medicines in their original container and protected from heat and light. Do not store in humid places such as the bathroom. Keep them out of children's reach, locked up if possible. | 2019-04-25T11:02:25 | https://www.childrensmn.org/educationmaterials/childrensmn/article/15708/retinoic-acid-for-cancer-therapy/ |
Category: SEWING MACHINE (6 records) (AUCTION ID# 501) 2/12 ***END DATE HAS CHANGED PER SELLER REQUEST*** ATTENTION QUILTERS & SEAMSTRESSES - THIS AUCTION IS THE LIFELONG LIQUIDATION OF A LOCAL SEAMSTRESS - FABRIC - SEWING MACHINES - CRAFT SUPPLIES - QUILTING TOOLS - APPLIQUES - LACE - TRIM - ORGANIZERS - FABRIC - THREAD - STORAGE CONTAINERS - SCISSORS - QUILTING BOOKS - QUILTING PATTERNS - QUILTING FRAME - SEWING PATTERNS - HOSPITAL BED - DID WE MENTION FABRIC - FOR SALE - TUESDAY FEBRUARY 12TH, 2019 STARTING AT 8:00 P.M.
Description: Singer Simple sewing machine.
Condition: This machine powers up. No further tested.
Description: Shark by Euro Pro sewing machine.
Description: Brother sewing machine m/n SQ9000 with carrying case.
Description: Brother LS-1217 sewing machine with cover.
Description: 1 drawer plastic storage full of sewing machine parts. | 2019-04-21T20:35:54 | https://www.innovativerevenuesolutions.net/cgi-bin/mmlist.cgi?irsauction14/category/SEWING-MACHINE |
Lettuce, kale and baby spinach topped with parmesan and zaatar croutons, served with caesar dressing.
Chopped lettuce, spiced chicken strips, sauteed bell peppers and caramelized onions, avocado, red kidney beans, sweet corn, shredded cheddar in our cilantro-lime dressing.
Shrimps, egg noodles, carrots, cabbage, snow peas and bean sprouts topped with fresh coriander, toasted sesame and cashews. Sesame-soy dressing. | 2019-04-20T04:25:33 | https://www.rightbite.com/rightbite-express/salad-bowls.html |
To sum Siam Square up in a word, 'eclectic', would be about right. An abundance of food options pepper the streets, from classic Thai street food to global delicacies, to sweet and simple sandwiches and pastries. The Siam Discovery Centre and Siam Paragon are home to the ultimate fashion café – Greyhound (he of the sculptured smock). Greyhound is a gimmick restaurant, riddled with quirks and an impressive fusion menu, a haunt of high-society and media types.
The Hard Rock Café is another popular choice, for those who enjoy dining alongside Jimi Hendrix and John Lennon memorabilia. The usual burgers, steaks and Tex Mex are thrown in for the ultimate Rock 'n Roll dining experience. For upscale dining, the high concentration of five-star hotels around the area provides some of the city’s most delectable dishes in unparalleled surroundings.
After You Dessert Café is diminutive in size, but massive in reputation; this bright and airy café is located next to the Gourmet Supermarket and is recognisable by the queue of people lined up outside. The cakes and desserts, obviously, are mouthwateringly good, and they also serve a limited selection of savoury food including fried breakfasts, pancakes with bacon and waffles with smoked sausage. The ice coffees and frappuccinos look as though they've been crafted into shape by a sculptor. Owing to their success, After You has maximized their floor space so tables leave scant room for elbows, but it all helps to create an atmosphere that is lively and exciting.
This Boston-owned bakery ('Au Bon Pain' meaning 'the place of good bread') gives customers the option to design their own sandwich through ticking off preferences of bread and fillings via a clipboard, so fear not any language barriers. Beyond sandwich design you can opt for a tailor-made treat or choose from the delicious selection of pastries (both sweet and savory) on offer. Even if you’re not feeling that hungry, the coffee here is great; both iced and hot.
Belguardo’s head chef Marco Camarrata sums the restaurant's ethos up as, "fresh, simple, and imported". The open kitchen and predominant use of natural light lends an extra sense of space to the restaurant – Belguardo fittingly translates as 'beautiful vista'. The menu features all your typical Italian treats from pastas, pizzas, steaks to risottos and Belguardo also rustles up some mean desserts.
For those serious about Japanese ramen, this noodle house offers award-winning recipes whipped up by the 2002 TV Champion’s Best Ramen Chef, Yasuji Morizumi. The menu features eight types of ramen, including the signature shoyu zaru ramen, plus a selection of side dishes such as gyoza and chicken tatsuta-age. Besides the pedigree title, what makes Chabuton different is the perfectly cooked noodles that goes so well with the complex taste and aroma of the soup.
As Chinese restaurants go in Bangkok this is a contemporary and up-market affair, offering no compromise on food, quality and service, unlike some of the cheaper Cantonese venues around the city. In between shopping we recommend a pit stop here where you can sample the array of Hong Kong-style dim sums on offer at lunchtime. The menu offers a large selection of mains from seafood, lobster and prawn dishes to specialty bird's nest and shark fin soup.
If you stop at Doo Dee Siam for the first time and think this is a restaurant for teens, you would be right. This is the place for a proper local experience, a simple place where young groups come and eat at great prices. Located just behind the old classic Lido Cinema on the second floor of a rather run down shopping gallery, this colorful restaurant serves a lot of Vietnamese and Thai dishes including classic Phad Thai, Som Tum and fried rice, but the most interesting is their variety of spicy noodle soups. If you have a craving for hot stuff, the well illustrated menu comes with something unusual: each dish is 'Spice Rated', from 0.5 which is what you would call 'pretty spicy' to a level 3 which is what locals would call 'seriously spicy'. Broth is dark and has an intense flavour, using more lime juice than average, creating the signature taste of Doo Dee Siam restaurant. Doo Dee Siam is a fun place in the back of a cinema but might not be for everyone, it's fun to go and do as the locals do.
Specialty roast duck restaurant originally from London, this is only the second branch worldwide and has remained true to its traditional Chinese-inspired menu with a variety of seafood, crispy pork belly and tofu dishes. The real draw card, however, is the dish on which the restaurant made its name: succulent roasted duck. The signature dish can be ordered in two sizes: half duck for 600baht or a whole duck for 1,100baht. The duck sauce is rich, yet delicate, and the cooking method is tried and tested to deliver consistency. This is a classy restaurant with an international reputation and should be the first choice for duck lovers.
Fast, friendly and efficient, the cafe presents an imaginative selection of Thai food, pasta, great sandwiches, and a few Western favourites. All are reasonably priced with generous servings, accompanied by a hearty choice of beers, wine and many creative cocktails.
Location: Siam Centre, Ground floor.
This Japanese fusion restaurant features an array of imported meats including red whale meat, horse meat, kobe beef, and Matsuzaka beef. For a fusion touch, try grilled foie gras sushi, or romaine lettuce and cheese salad. The extensive sushi menu comes highly recommended as does the prime tuna belly and spring onions.
Two decades old, this 30-cover restaurant has Hong Kong-style noodles with grilled duck or pork. Homemade egg noodles, shrimp wonton soup and khao moo deang (rice and grilled pork topped with red sauce) are other specialties.
This sweets café serves up a range of delectable a la carte ice creams, waffles and cakes. Housed inside a tastefully decked out shop, with DIY chandeliers, rough-painted brick walls and buffed concrete floors, iberry is a welcome alternative to existing ice cream chains like Swensens, Baskin Robbins and Haagen Dazs. For starter, it offers a creative selection of flavoured ice creams, most with a local touch, such as santol sorbet, Thai iced tea, green mango, pandanus, and a whole lot more that will keep you going back for more. There’s also an array of themed ice creams, such as the high-tea ice cream set, which you can share with your friends.
Fusing culinary techniques of the East and West, this cosy dining establishment is all about creativity and freshness. The menu highlights an exciting range of colours, tastes and textures, presented as edible art on a plate. Ingredients are selected daily and prepared according to traditional Japanese cooking style, whereas Western techniques are applied to enhance the flavour and presentation. The atmosphere is laid-back and contemporary, with sakura blossoms painted on a deep red background, black leather chairs and bright yellow sake wall. Coupled with impressive service, Izuya has all the elements for a pleasant dining experience.
Feast away on spring greens with fried shrimp, beans, pork crackling with herbs and a tasty pork dip. Savoury gourami fish salad is highly recommended, with its explosion of spicy onions, lemongrass, mint and other piquant ingredients spread on crispy pieces of fish. Bean curd and mixed vegetables with minced chicken in gravy is served in a big bowl alongside baby corn, carrots and thinly sliced mushrooms that balance with extremely soft chunks of tofu.
This quick-and-easy eatery is a good place to drop by for a casual meal. With wooden square stools and tables, the place almost feels like a dim sum joint in Hong Kong, except for the sleek white floors and brightly lit interiors. The menu offers everything from roasted duck noodle soups, barbecued pork over rice and congee to a whole spectrum of Issan dishes like som tam, bamboo shoots salad and grilled marinated chicken. Service is quick and efficient.
Fusing fast food and casual dining concepts, Pepper Lunch serves up sizzling sukiyaki, teriyaki, steaks (Australia and New Zealand imported beefs) and meat over rice dishes on an iron hot plate. Your order arrives at the table raw but slowly cooked through as you season the dish with either honey brown sauce (amakuchi) or garlic soy sauce (karakuchi). The innovative concept has proven popular among new-generation Thais, who enjoy an element of fun, even while eating. Pepper Lunch is a franchise of the Japanese chain with the same name.
Rot Dee Det (which translates to Tastes So Good) is slap bang in the centre of Siam Square, the fashion centre of Bangkok, and attracts an intriguingly eclectic mix of Bangkok society all drawn by the rows of Thai dishes presented in metal trays, and a noodle station with dark, dense and flavoursome broth. Items start from 40 baht and the white tiles and barren interior design is a clear sign that Rot Dee Det is a local Bangkok restaurant with its focus clearly on the food. Dishes here are served on the small side but come bursting with flavour so we recommend ordering at least a couple of options. Come around lunch and you will struggle to find a seat, as local restaurants are slowly pushed out of Siam Square with Japanese and American franchises taking their place.
What to Order: Browse the cooked selection for anything that takes your fancy, and a bowl of beef noodles.
This shabu-shabu franchise is a ubiquitous presence in shopping malls across Bangkok, often with lines of people waiting to get inside to feast for 1.5 hours for 350 baht. Each Shabushi branch is designed in the same way, very much like a sushi train restaurant. Stools are lined up along a revolving conveyor belt which delivers the variety of ingredients to your seat, which you then boil in your pot of either spicy tom yum flavour broth or a lighter, salty broth. Ingredients range from fish, clams and shrimp, to beef, chicken and all manner of vegetables. There is also a sushi area, free soft drinks and ice cream.
If you like the taste of your noodle soup complex and spicy, then sample a bowl of original boat noodles here. The portions are small enough to allow for a few bowls, and the prices are also minimal. Decked out with wooden square stools, tables and the signature rowboat out front, this compact-sized eatery is always packed with diners. With early success, the restaurant now offers additional items on the menu, including som tam, Issan-style spicy pork rib soup, Thai-style sukiyaki, phad thai, and more.
Vanilla Industry in Siam Square announces its presence with an intriguing old fashioned wooden door front that stands out amongst the fashion boutiques in this part of Bangkok. Step inside and you are greeted by a vintage looking counter that displays some of the tastiest cakes we have seen, from banoffee pie to crumbly cookies. This bakery opened in 2004 and has been delighting customers ever since with their blend of yesteryear, delicious sweet treats and excellent prices. | 2019-04-25T14:29:12 | http://www.bangkok.com/siam-ratchadamri/where-to-eat.htm |
Please allow two hours for your first visit and bring the following items: All insurance cards, driver’s license or photo ID, eyeglasses or contacts with boxes and a list of all current medications.
Dr. Weeks will perform a thorough eye exam for each patient based on his/her individual needs or symptoms. Dr. Weeks will offer medical or surgical treatment options when needed.
Introducing the new Patient Portal for all of your records and needs!
Simply log into your account and you’ll be able to see your bill, past visits, and even pay online!
We have state of the art ophthalmic equipment in order to perform high quality diagnosis and treatment.
We have a qualified and personable staff ready to serve you and help meet your eye care needs.
We want your patient experience to be as good at Auburn Cataract and Eye Clinic as can be found.
The online client portal makes it easy for our existing clients to update their information, check account balances, and schedule future exams.
Our site is compatible with your mobile device. We want to provide an easy-to-use and appealing site, no matter where you choose to view from.
We do our best to make your visit as comfortable and quick as we can, without sacrificing the attention and care that you deserve. | 2019-04-18T10:58:53 | http://auburneyeclinic.com/ |
STARKVILLE, Miss. -- Elizabeth Gregory North, head of the Mississippi State University Extension Service Office of Agricultural Communications, is the newest member of the Southern Public Relations Federation’s Hall of Fame.
SPRF established a Hall of Fame in 2010 to recognize the exceptional accomplishments, commitment and leadership of professional public relations practitioners and educators from across the Southeast.
North has worked for more than 25 years as an Extension and land-grant communications and marketing professional. A recognized leader in her field, she has earned numerous state and national awards. She began leading strategy, branding, marketing and communications for the MSU Extension Service in 2013.
In this role, North created a quarterly magazine, Extension Matters, to promote the impact of Extension, as well as an award-winning video series, The Food Factor, which focuses on food, nutrition and healthy lifestyle choices. She also spearheaded a campaign with quarterback Dak Prescott to promote colorectal cancer screening.
In addition to SPRF, North is active in many other professional associations, including the Public Relations Society of America and Public Relations Association of Mississippi. She was named national president of the Association for Communications Excellence in August 2018.
Suzanne Steel, ACE past-president and assistant director of marketing and communications for the College of Food, Agricultural and Environmental Sciences at Ohio State University, provided another letter in support of North’s nomination.
“Please know that her influence has benefitted universities and organizations nationwide, through her work, and through the work of others who have learned from Elizabeth,” she wrote.
Before joining MSU, North spent nearly 17 years with the Texas A&M University System, in a number of marketing communications roles for Extension and research. She began her professional career in Extension communications for the Alabama Cooperative Extension Service from 1989 to 1993 at Auburn University.
North earned a bachelor’s degree in English from Auburn and a master’s degree in English literature from University of Rochester in New York. She has worked toward her doctorate, most recently with Texas A&M, in agricultural education with a special emphasis in communication.
SPRF leaders announced the Hall of Fame honor at the annual meeting on Sept. 24 in New Orleans. | 2019-04-24T14:01:40 | https://extension.msstate.edu/news/feature-story/2018/msu-department-head-earns-hall-fame-honor |
Principle of the metasurface holography design and statistical results of the number of each nanofin (different cross-sections and orientation angles) contained in the designed metasurface holograms. Schematic illustrations of polarization multiplexed holograms based on dielectric metasurfaces. The red and blue arrows indicate the polarization of the incident light and the transmission axis of the polarizer placed behind the metasurface sample. The red, blue, and green color of the reconstructed images (the words “holography”, “meta”, and “surface”) represent components of the output light, respectively. a) Two channel polarization and an angle multiplexed hologram based on metasurfaces composed of nanofins with different cross-sections but fixed orientation angles, which can be used to reconstruct two sets of off-axis images. b) Multichannel polarization multiplexed hologram based on metasurfaces composed of nanofins with different cross-sections and orientation angles, which can be used to reconstruct three independent images and all combinations of these images (12 channels in total). c) Two-channel polarization- and angle-multiplexed hologram (enables appearance of “cartoon tiger”, “cartoon snowman”, “teapot”, “cup”), b) Multichannel polarization-multiplexed hologram (appearance of the word “holography”, “meta”, “surface”) c) Multichannel polarization-multiplexed hologram (appearance of “dice”) d Multichannel polarization-multiplexed hologram (appearance of a “cartoon person”). Credit: Light: Science & Applications, doi: 10.1038/s41377-018-0091-0.
Nevertheless, the full capacity of all polarization channels remains to be explored for improved information storage capacity within metasurface holograms and in holographic optical devices. In a recent study, Ruizhe Zhao and co-workers demonstrated a new method to realize multichannel vectorial holography for dynamic display and high-security applications. In the study, birefringent metasurfaces were explored to control polarization channels and process very different information through rotation. The reconstructed vectorial images could be switched from one form to another with negligible cross-talk by selecting a combination of input/output polarization states. The results are now published in Light: Science & Applications.
The two-channel polarization and angle-multiplexed hologram represents a cartoon tiger, cartoon snowman, teapot and teacup. Credit: Light: Science & Applications, doi: 10.1038/s41377-018-0091-0.
The scientists first derived a multiplexing algorithm to support the dynamic vectorial holographic display and encryption process. By using the correct polarization keys, the receiver could obtain the exact information delivered. By increasing the complexity of such images, even higher flexibility was obtained alongside detailed analysis of the reconstructed vectorial image properties. Since the device containing metasurfaces is compact in size, in practice, it can be easily transported with encoded information.
To pattern the design of interest, Zhao et al. engineered several dielectric silicon metasurfaces on top of a glass substrate using plasma etching, followed by electron beam lithography. The metasurfaces were composed of 1000 x 1000 nanofins, i.e. nanostructures with the ability to augment heat transfer via surface area enhancement and liquid-solid-interactions. The researchers studied two schemes of multiple polarization channels; with or without rotation using the birefringent dielectric metasurfaces—to realize the holograms.
a) Schematic illustration of an amorphous silicon nanofin positioned on a glass substrate. The metasurface will be composed of a periodic arrangement of such unit-cells. b–e) Simulation results for the amplitude and phase of the transmission coefficients txx and tyy shown for a 2D parameter optimization by using a rigorous coupled wave analysis method. The length and width of the nanofin are both swept in the range of 80–280 nm at an incident wavelength of 800 nm. Credit: Light: Science & Applications, doi: 10.1038/s41377-018-0091-0.
The birefringent dielectric metasurfaces were designed using silicon nanofins on top of a glass substrate. To achieve the desired phase shifts, 2-D parameter optimization was conducted using a rigorous coupled wave analysis (RCWA) method. The RCWA semi-analytical method is typically applied in computational electromagnetics to solve scattering from periodic dielectric structures. The length L and width W of the nanofin were in the range of 80 to 280 nm, height at 600 nm and period size P at 400 nm. The values were carefully selected to ensure the phase of the output light eliminated any undesired orders of diffraction. For the simulation, the nanofin was placed on a glass substrate and subjected to a fixed wavelength of incident light at 800 nm. Simulation results indicated the amplitude of transmission for most nanofins with diverse cross-sections were beyond 90 percent efficiency. The scientists determined orientation angles of the nanofins using equations derived in the study to experimentally demonstrate multichannel polarization multiplexing.
Experimental setup and scanning electron microscopy images of the fabricated metasurface samples. a) The experimental setup for the observation of the holographic images. The two linear polarizers (LP1, LP2) and two quarter-wave plates (QWP1, QWP2) are used to set the precise polarization combination for the incident/transmitted light. The lens images the back focal plane of the microscope objective lens (×40/0.6) to a CCD camera. b–e) Scanning electron microscopy images of two typical fabricated silicon metasurface samples shown with a top and side view. The metasurface holograms are composed of 1000 × 1000 nanofins with different cross-sections and orientation angles. Credit: Light: Science & Applications, doi: 10.1038/s41377-018-0091-0.
For optical characterization of the metasurface holograms, Zhao et al. used an experimental setup. The magnifying ratio and numerical aperture of the objective lens were carefully chosen to collect all the diffraction light from the sample and reconstruct holographic images in the Fourier plane. The scientists used a second objective/lens to capture the Fourier plane on a CCD camera. They also separately observed two scanning electron microscopy images of the samples with or without rotation to characterize the engineered surface.
As a proof-of-principle, using the metasurfaces, Zhao et al. constructed holographic images of a cartoon tiger and a snowman that appeared with high fidelity and high resolution when illuminated by x-polarized light. When the incident light was switched to y-polarization, the reconstructed images changed to a teapot and a teacup. In this experiment, only two polarization channels were available in the setup, with both pairs of the holographic images reconstructed and made to disappear simultaneously by rotating the polarizer behind the sample. The experimental results were in agreement with the simulation to confirm the study's fundamental design principle. The net diffraction efficiency of the hologram was defined as the ratio of intensity of the single reconstructed image to the power of incident light.
Multichannel polarization-multiplexed holograms (“Dice”). Credit: Light: Science & Applications, doi: 10.1038/s41377-018-0091-0.
The multichannel hologram maintained a relatively large working bandwidth since the reconstructed images could be observed away from the designed wavelength of 800 nm. The study established a design and engineering technique that combined birefringent properties of simple nanofins used as the building blocks, with extra-design freedom of rotation matrix and smart multiplexing algorithms. The results enabled high-dimensional multichannel polarization multiplexed holograms, with up to 12 polarization channels. In this way, efficient light-based encryption and integrated multichannel holographic display techniques can pave the way for advanced communication in high security applications. | 2019-04-25T04:44:55 | https://phys.org/news/2018-12-multichannel-vectorial-holographic-encryption.html |
Roughly 80 percent of men experience back pain, but now there’s hard-core pain relief. An abs workout may help relieve back pain, say researchers in Brazil.
A back-saving abs workout can help everyone from elite cyclists to desk jockeys. McGill recommends a 3-move routine consisting of the front to side bridge, curlup, and bird dog. | 2019-04-21T12:50:31 | https://www.menshealth.com/fitness/a19528919/3-best-moves-prevent-back-pain/ |
Transportation, Beverages, Travel insurance in tour.
Tips for tour guide, driver.
Expenditure of a personal nature, tips, such as souvenirs, laundry, emergency transfers & etc.
Necessary things to bring: Passport ( Valid passport is required when chech-in), sunglasses, hat, insect repellent, swimsuite, cash. | 2019-04-24T06:37:54 | http://sapatoursfromhanoi.com/tour/dugong-sail-2-days-1-night/ |
In 2001, the governments of South Carolina and Queensland in Australia forged a sister state relationship. Less than a year later, that relationship generated one of the most profound gifts that the government of Australia is willing to bestow—koalas.
Two male koalas arrived at Riverbanks in January 2002 from the Hirakawa Zoo in Japan. A little more than a year later, two female koalas were transferred to Riverbanks from the David Fleay Wildlife Park on Queensland's Gold Coast. These four koalas were the first authorized by the Australian government to be transferred to the United States since 1990. Koalas are considered a national treasure by the Australian government and are rarely made available to zoos in other countries.
The Koala Knockabout exhibit at Riverbanks was designed with the long-term management of koalas in mind. The facility contains two spacious indoor exhibits and one outdoor exhibit for the koalas, as a koala lives a solitary life. Four off exhibit areas increase the holding capacity to six adults and, hopefully, their offspring. A walk-in cooler holds the eucalyptus leaves that are shipped in each week.
The day-to-day care of koalas is quite involved. They eat only a few types of eucalyptus leaves, and unfortunately, will not eat the species commonly found in Columbia. Eucalyptus is flown in from Florida, Arizona and the South Carolina coast twice a week to ensure freshness. The horticulturists at Riverbanks also have established a grove of eucalyptus to use in emergencies, but the amounts required for day-to-day feeding are too great for the growing space available at Riverbanks.
When you visit Koala Knockabout, chances are you will see the koalas at rest. Koalas feed about four hours a day. The rest of their time is spent sleeping.
Koala Knockabout also is home to wallabies, lorikeets and reptiles and fish native to Australia. On the north side of the building is a large free-flight aviary, which is home to lorikeets. These are small colorful parrots that feed on nectar. Visitors can purchase small cups of nectar and enter the aviary to feed these beautiful birds. On the south side of the exhibit is a spacious area that represents more of the Australian Outback, with two species of wallabies and the outdoor koala exhibit. The indoor exhibit also includes a large aquarium filled with colorful Australian fishes and corals, and bearded dragons and water dragons represent the Australian world of reptiles.
Educational graphics abound with information about all the animals and South Carolina's sister state relationship with Queensland. As part of the relationship and as a result of the gifts, Riverbanks and the government of Queensland are collaborating on projects to benefit koalas living at the zoo and in the wild in Queensland.
In September 2004, one of the female koalas, Lottie, gave birth to her first joey and began, hopefully, a successful breeding program that will establish a new genetic line of koalas in the United States. Only a few zoos in the country have successfully bred koalas. | 2019-04-23T20:17:32 | https://www.riverbanks.org/media-center/highlights/koala-knockabout |
There’s just something about ’em … taste buds love Stuffed Bell Peppers. I’m not sure if it’s their delicious taste, their appearance or just the fact they’re not that complicated to prepare.
Either way, Stuffed Bell Peppers can serve as a side dish or as the main meal. That makes them double handy.
I cut the tops off of 3 bell peppers and removed the excess membrane and ribs. Be sure to put the bell pepper in a pan of water to parboil before making stuffed peppers otherwise the pepper will still be a bit crisp and not easily cut with a fork. Make sure the peppers are covered by water and boil for 5 minutes, drain and set aside.
I took the bell pepper tops and minced finely. I put my skillet on medium heat, added 2 tablespoons of Canola oil and added ¾ cup minced bell pepper and sauté for 3 minutes. Next I added ¼ cup minced onions and 1 tablespoon dried parsley and sautéed another 2 minutes. Last I added 1 tablespoon minced garlic and sautéed for about 30 seconds more. You have to be sure to keep stirring this so you don’t let it burn, especially when the garlic is added. I turned off heat.
I added 1 can (14.5 ounces, about 1 ½ cups) petit diced tomatoes to the mixture. I didn’t drain the tomatoes because the rice I’ll add soon will absorb the extra liquid. I turned the skillet on to simmer.
Next I added ½ tablespoon of fresh homemade dried oregano (you can use bought dried herbs) and ½ tablespoon of fresh homemade dried basil to the mix. I continued to stir and let the mixture simmer. I added 1 ½ cups of cooked rice (I used instant rice). The rice marries with all the flavors and absorb the liquids. Next I added 1 ½ teaspoons fresh ground kosher salt, a ¼ teaspoon fresh ground black pepper and 2 cups cooked ground pork.
The cooked ground pork was 4 leftover cooked boneless pork chops that I sliced and put into the food processor. I used 2 cups of the pork for the stuffing and still had another 2 cups left to use in another dish later.
I continued to stir as the mixture simmered for about 7 to 10 more minutes.
Removing the mixture from the stove, I placed it in a large bowl. Even though this is a stuffing mixture I concocted for the stuffed bell peppers, you could stop at this stage (add the cheese, if desired) and eat it as it is. It would go good on a bed of spinach. Just don’t add the eggs if you’re not going to cook it any further.
I added ½ cup Kraft shredded mild cheddar cheese and 2 large eggs (beaten) into the mixture. Once the mixture was blended thoroughly, I spooned it into the bell peppers. There was enough stuffing for 4 large bell peppers. I placed the peppers in casserole dish and baked them for 45 minutes in a pre-heated 350 degree oven.
These aromatic Stuffed Bell Peppers are delicious and easy to prepare. The stuffing is moist and flavorful.
Thanks for visiting today. If you decide to try this recipe, be sure to stop back by and let me know how it turned out or if you post it online just tag it with #thesurprisedgourmet. I’d sure like to know how it turned out.
Stuffed Bell Peppers make a delicious side dish or a savory main meal.
Cut tops off the 3 bell peppers and remove the excess membrane and ribs. Put the bell pepper in a pan of water making sure the peppers are covered by water. Boil for 5 minutes, drain and set aside.
Take the tops of the peppers and mince finely. Turn skillet on medium heat, add 2 tablespoons of Canola oil. Put in ¾ cup minced bell pepper and sauté for 3 minutes, add ¼ cup minced onions and 1 tablespoon dried parsley sauté another 2 minutes and add 1 tablespoon minced garlic sauté for about 30 seconds more. Be sure to keep stirring this so you don’t let it burn, especially when the garlic is added. Turn off heat.
Add 1 can (14.5 ounces, about 1 ½ cups) petit diced tomatoes to the mixture. Don’t drain the tomatoes. Now turn the skillet on to simmer.
Remove mixture from pan, put in large bowl. Add ½ cup Kraft shredded mild cheddar cheese and 2 beaten large eggs into the mixture. Once the mixture is blended thoroughly, spoon into the bell peppers. Should stuff about 4 large bell peppers. Place in casserole dish and bake 45 minutes in preheated 350 degree oven.
*Ground pork can be made from 4 cooked boneless pork chops that have been sliced and put into the food processor. There will be more than 2 cups of the ground pork after placed in the food processor.
**Even though this is a stuffing mixture concocted for the stuffed bell peppers, you could stop at this stage before you add the eggs and eat it as it is. It would go good on a bed of spinach.
With summer quickly drawing to an end and fall activities gearing up, it’s always good to have a couple of tasty side dishes you can prepare at a moments’ notice.
Today I want to share two dishes that are hits at our house. One is a longtime favorite and the other is one I came up with when I started out to make a salsa.
The longtime favorite is cole slaw and the new favorite is a delicious take on guacamole.
The guacamole dip came about this way. I had 2 avocados that weren’t as ripe as I had hoped, but I decided to use them anyway. I seeded, peeled, chopped and mashed them.
Next I added 1 teaspoon of onion powder, 3 teaspoons of lime juice, 1 teaspoon of Lawry’s Garlic salt, 1/4 cup of mayonnaise and 1/2 teaspoon cumin. These ingredient amounts came about a little at a time as I added, tasted and then added a little more.
Using a hand-held immersion blender I pureed all the ingredients together into a smooth and creamy mixture. This became perfect for a dip. In fact, the texture of the mixture is so creamy you could use it on sandwiches, hamburgers or hot dogs to replace mayonnaise or mustard if you wanted to.
Take 2 large avocados - seed, peel, chop and mash them.
Added 1 teaspoon of onion powder, 3 teaspoons of lime juice, 1 teaspoon of Lawry's Garlic salt, ¼ cup of mayonnaise and ½ teaspoon cumin.
Using a hand-held immersion blender, puree all the ingredients together into a smooth and creamy mixture. This becomes perfect for a dip. In fact, the texture of the mixture is so creamy you can use it on sandwiches, hamburgers or hot dogs to replace mayonnaise or mustard if you desire.
Cole slaw is a great side dish that goes well with hamburgers and hot dogs. But is also makes a tasty side dish for full meals.
Taking a half of a medium head of cabbage, I chopped it up into pieces that would fit into the chute of my food processor. Next I peeled one large carrot. I put the cabbage and carrot through the shredding disc of the food processor creating a fine looking texture similar to angel hair cole slaw you would find in a grocery store.
Placing the cabbage and carrot mixture in a large bowl, I added 1 tablespoon of dried parsley and 2 teaspoons of celery seed.
Using a jar with a lid, I mixed 2 tablespoons of sugar, 3 tablespoons of apple cider vinegar and 1 cup of mayonnaise shaking the jar until the ingredients were well blended. Then I poured the dressing mixture over the cabbage ingredients until I got the desired moisture consistency I wanted, stirring well as I added. By mixing the dressing separately, you can adjust it to make the cole slaw as moist or dry as you prefer. The cole slaw comes out with a creamy, tangy taste.
To make the dressing mixture I used a mayonnaise jar, but a mason jar with a lid will work too. The cole slaw (covered tightly) will keep well in the refrigerator for several days.
Do you have any favorite side dishes that you can prepare at a moment’s notice? Do you have a favorite guacamole dip recipes?
Homemade cole slaw goes great with hamburgers and hot dogs or a full meal.
Take a half of a medium head of cabbage, chop it into pieces that will fit into a food processor chute. Next peel one large carrot. Run the cabbage and carrot through the shredding disc of the food processor for an angel hair-type texture.
Place the cabbage and carrot mixture in a large bowl, Add 1 tablespoon of dried parsley and 2 teaspoons of celery seed.
Using a jar with a lid, mix 2 tablespoons of sugar, 3 tablespoons of apple cider vinegar and 1 cup of mayonnaise shaking the jar until the ingredients are well blended. Then pour the dressing mixture over the cabbage ingredients until you have the consistency you want, stirring as you go. Covered tightly the cole slaw keeps well in the refrigerator for a couple of days. | 2019-04-23T18:23:34 | http://thesurprisedgourmet.com/category/side-dishes/ |
These are for the finished product!
how cute would any little person look in these adorable monster or alien hats.
The first color chosen will be the hat color.
The second color chosen will be the eye and horn color.
If you would like anything different then that please convo me and I will be happy to accommodate.
please allow 2-4 business days for processing.
Has monster eye, horns, and sticking out it's tongue! Would make a great out and about hat or even a photo prop! | 2019-04-25T06:15:36 | https://marketplace.zibbet.com/4my4creations/5-year-and-up-monster-hat |
New York, NY – HG Contemporary is pleased to announce an exhibition of new work by AICAN + Ahmed Elgammal. Entitled Faceless Portraits Transcending in Time, the exhibition will run from February 12, 2019 through March 5, 2019.
HG Contemporary proudly presents Faceless Portraits Transcending Time, a collaboration between an artificial intelligence named AICAN and its creator, Dr. Ahmed Elgammel. The exhibition shows two series of works on canvas portraying uncanny, dream-like imagery generated by AICAN excavating the ageless themes of mortality and representation of the human figure. The first series examines this joint effort between man and machine as a historically specific moment in the chronology of image-making; the second focuses on how artificial intelligence serves as a mirror to reflect human (sub)consciousness.
The first series investigates the history of the image with portraiture as its focus. At our present moment, the advent of AI-generated imagery asks us to consider the work of art in the age of not only mechanical reproduction but also algorithmic production. “Deepfake” videos of political figures now challenge the status of the image as an index of authenticity. Further still, the ability of algorithms to generate imagery from their “imagination” causes a severance between imagery and reality altogether. If photography freed painting from the task of representation, then how will AI change how we make visual culture?
The second series plays with the tradition of memento mori. In doing so, it highlights the ability of AI’s pseudo-intelligent neural networks to let us more closely examine the nature of visual meaning-making, via a reflection of our own intelligence in a machine. “Deep learning” algorithms have propensities that eerily mimic the human brain, exhibiting behaviors such as fractal-like hallucinations or producing abstract compositions that invoke seemingly atavistic or subconscious sources.
Ahmed Elgammal is the founder and director of the Art and Artificial Intelligence Laboratory, and a professor of computer science at Rutgers University. He developed AICAN, an autonomous AI artist and collaborative creative partner. Dr. Elgammal’s research on knowledge discovery in art history and AI art generation, received wide international media attention, including reports on the Washington Post, New York Times, NBC News, CBS News, the Guardian, the Daily Telegraph, Science News, New Scientist, and many others. In 2017, an Artsy editorial acclaimed AICAN as “the biggest artistic achievement of the year”. In 2016, a TV segment about his research, produced for PBS, won an Emmy award. AICAN art has been shown in several technology and art venues in Los Angeles, Frankfurt, San Francisco, and New York City. | 2019-04-21T16:20:50 | http://www.hgcontemporary.com/exhibitions/faceless-portraits-transcending-time |
These days with so many applications using filters for photographs, it is easier to manipulate images to satisfy any whim or desired look. However, only a truly professional can ensure superior and sharp images that you can display with pride. My name is Edit and I am a London-based freelance photographer with a unique approach inspired by cinematic imagery. I have over 10 years of experience and I specialise in weddings, events, headshots, portraits, aerial photography and a whole lot more. I have a distinctive style and reliable technical skills to maximize the potential of my camera and use a mixture of flashes to produce high quality images. I can also confidently use Adobe Photoshop, Capture1 and Adobe Lightroom to ideally edit images and enhance them as per the wishes of my client and have my own studio equipment and speed light flashes. I have worker on several major commercial projects with clients in the fashion industry and I love to interact with clients and delivering the superior results they are used to. I’m dedicated to my craft and I believe that great customer service is essential to suitably addressing client needs. I once worked as a photographer and retoucher at a diamond photo studio and I was responsible for the post-production digital process and used Adobe Photoshop and Lightroom to manipulate light and exposure composition levels, proficiently remove blemishes, dodge and burn functions and various other digital tools. Now as a freelance photographer, I like to provide unforgettable and exceptional images that my clients can cherish for a lifetime. My process starts off with meeting clients to discuss their expectations, maintaining a great rapport throughout, and gaining their trust in my abilities. If you’re looking for a reliable and talented photographer with a creative perspective and a reputation for delivering outstanding images, please do contact me and I look forward to hearing from you. | 2019-04-19T16:48:04 | https://focusdown.co.uk/about-me |
-In one study involving asthma, people using a placebo inhaler did no better on breathing tests than sitting and doing nothing. But when researchers asked for people’s perception of how they felt, the placebo inhaler was reported as being as effective as medicine in providing relief.
-In another study, people were given a placebo and told it was a stimulant. After taking the pill, their pulse rate sped up, their blood pressure increased, and their reaction speeds improved. When people were given the same pill and told it was to help them get to sleep, they experienced the opposite effects.
Several studies revealed an effect of caffeine on maximal strength. For instance, studies that have tested percent muscle activation and maximal muscle strength of the knee extensors under isometric conditions have shown that caffeine is capable of increasing voluntary activation and strength. A 2014 study reported that caffeine can increase not only concentric (i.e. lifting the weight) and eccentric (i.e. lowering the weight) maximal strength, indicating that caffeine increased maximal strength regardless of the contraction mode.
Caffeine seems to work especially well for increasing performance in the gym. For example, 13 resistance-trained men ingested a caffeinated (179 mg) energy drink or placebo solution 60 minutes before completing a bout of the following exercises: bench press, deadlift, prone row, and back squat exercise to failure at an intensity of 60% 1-repetition maximum. Subjects who consumed the caffeinated beverage performed more repetitions to failure in all exercises. Another study had 15 women consume caffeine (6 mg/kg) or placebo (PL) seven days apart. Sixty min following supplementation, participants performed a one-repetition maximum (1RM) barbell bench press test and repetitions to failure at 60% of 1RM. They discovered that 1-RM strength was greater during the caffeine condition in these resistance-trained women.
4) Told placebo, given caffeine.
Maximal voluntary concentric force and fatigue resistance of the knee flexors and extensors was measured using isokinetic dynamometry. So we have a interesting study which compared the direct effects of caffeine vs the placebo effect. At the end of the study, a significant and equal improvement in peak concentric force was found in the told caffeine, given caffeine subjects and told placebo, given caffeine trials. Despite participants believing caffeine would evoke a performance benefit, there was no effect of told caffeine, given placebo. Caffeine caused an improvement in some aspects of muscle strength, however there was no additional effect of expectancy. Performance was poorer in participants who believed caffeine would have the largest benefit, which highlights a link between expected ergogenicity, motivation, and personality characteristics. | 2019-04-24T21:59:55 | http://www.infinitelabs.com/caffeine-legal-performance-enhancer/ |
Food and Agriculture Organization of the United Nations (FAO) continues to support the government-led efforts to address food security and livelihood needs in the six districts most affected by the earthquakes: Sindhupalchowk, Nuwakot, Dhading, Gorkha, Rasuwa, Dolakha.
Six months after the earthquakes, vulnerable farmers in the worst-affected districts still need agricultural inputs to continue the rehabilitation and reconstruction process and revive the agricultural sector.
FAO has already completed an emergency distribution of 42,000 5kg bags of rice seed in advance of the monsoon planting season. It has also distributed 30,000 durable grain and seed storage bags, with 40,000 more to follow, and nearly 20,000 25kg bags of high-nutrition animal feed. The vegetable seed packet distribution recently completed reached 50,000 households.
“Since the vast majority of rural families are dependent on agriculture for livelihoods, it is FAO’s priority to provide the farmers with the necessary support to revive their crop and livestock production,” said Dr Somsak Pipoppinyo, FAO Representative in Nepal. Dr Somsak extended gratitude to the donors, the government and nongovernmental agencies and the civil society for their generous support to the affected farmers.
In the next few months, FAO will continue distributing farming inputs, grain and seed storage bags and mineral blocks for surviving livestock. Through 240 women’s group, FAO will also distribute plastic sheets for the construction of tunnels to support winter vegetable production to 6 000 households. Twelve community-managed irrigation schemes have been identified and assessed for the provision of support to repair damaged reservoirs and channels.
Food production is still under significant pressure due to the on-going border blockade in the southern part of the country that hinders the import of seeds, fertilizers and other agricultural inputs. FAO is working with government partners to resolve these issues by identifying alternative assistance to support vulnerable populations.
Achieving food security for all is at the heart of FAO's efforts – to ensure people have regular access to sufficient high-quality food to lead active, healthy lives. Our three main goals are: the eradication of hunger, food insecurity and malnutrition; the elimination of poverty and the driving forward of economic and social progress for all; and, the sustainable management and utilization of natural resources, including land, water, air, climate and genetic resources for the benefit of present and future generations. | 2019-04-24T00:48:45 | https://www.spotlightnepal.com/2015/11/03/fao-responding-to-quake/ |
On opening night, the new Clippers point guard, , certainly did not NFL Jerseys Nike care. And yet, he opted to reveal his decision a 45-minute TV special — a stunt reminiscent of constipation mayo clinic and of LeBron ‘ identically titled ESPN special 2010, when the NBA announced he was leaving the Cleveland Cavaliers for the Miami Heat. They’ve brought a serious upgrade, Hamilton said of stomach bloating and pain and of ‘s improved performance this weekend. LeVert grabbed one rebound and had four assists, tallying a plus-minus of severe constipation symptoms and of -3 his 29 of severe bloating and of playing time. As brilliant as Bale’s first goal was, it only had a nine percent probability of do i have a food intolerance and of being scored, and his MLB Jerseys Usa second was rated as just Cheap NFL Jerseys Paypal 0 xG. We really go as Shatori goes, coach Brenda Frese said. To tell you the truth, he said, we kind of food sensitivity tests and of dread it. Although LeBron is working on cementing his GOAT case, Curry has a lot he could prove this series as well. Game FIC Scores Anthony , State ? He’s trying not to be mean, but the answer is basically no. Kobe rarely speaks of home allergy test and of this time his life anymore.
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opinion, the most important thing represented by the recently announced club-driven initiatives, is that the options available to present a viable L.A. Sports bettors tend to view teams as a whole entity – the Yankees are good, and the Pirates are really bad. Like someone would say we should do the beginning like the beginning of list of common food allergies and of ‘Black Swan,’ Chopra said. The Colombian designated player gathered a loose ball at the top of sensitivity to nuts symptoms and of the 18-yard box, dribbled through four defenders and sent a shot from a difficult . | 2019-04-23T10:43:27 | http://haornews24.com/?p=2516 |
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Kansas is often a US state called after Oh river. The state of hawaii is encompassed by Nebraska on the to the north; Missouri for the east; Oklahoma on the to the south; and Denver colorado on the western. It is put into 105 counties with 628 towns. The overall economy of the talk about is sustained by both manufacturing and farming products.
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Tourism, the main method of obtaining economy and it's experiencing the down turn in the recent instances. Recession could be the main reason regarding decreased variety of visitors to Guam modify in the weather conditions adds to the item. Why is the surroundings of the talk about suffering really serious effects of smog? The answer could be none other than this careless actions of inhabitants of the talk about i.e. improper removal of the waste.
No matter where you reside you know that you'll want to keep your condos up to date if you own all of them and rent all of them out. Individuals want to live in a nice, as well as updated residence.
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Developing a roll-off dumpster is essential for virtually every construction challenge, major home rehabilitation venture and for other several industrial uses. However, if you have never hired before, this technique could seem overwhelming and stressful.
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Be wary of a corporation that is somewhat new. They might nevertheless be learning the ropes and producing mistakes. You don't want to hire a company that could damage your own driveway or otherwise meet their particular scheduling promises. | 2019-04-19T01:35:22 | https://dumpsteramerica.com/pennsylvania/rent-a-large-dumpster-goodville-pa/ |
(Toronto) The Toronto Environmental Alliance (TEA) strongly supports the provincial government’s announcement today to ban the burning of used oil in space heaters. The move is a victory for TEA and other environmental groups who for years have identified the practice as a source of highly toxic local air pollution. The ban will not only improve air quality but will also remove a potential health threat to workers and local residents.
“We applaud Minister Broten’s ban on the burning of used oil, this will help address Toronto’s concerns by reducing harmful pollutants in our air and is a good first step towards promoting recycling for oil,” said Lina Cino from the Toronto Environmental Alliance.
In the spring of 2006, TEA disclosed information on over 40 facilities that have the right to burn motor oil even though the City of Toronto passed a bylaw banning the practice in 2000. TEA’s disclosure triggered outcry from the City of Toronto and residents groups.
“The reality is that most people are unaware of dangerous pollution being created by local neighbourhood based businesses, and governments do little to provide access to such information” said Lina Cino.
The ban will phase out all existing permits by June 2009, and the government will no longer consider new applications, such as the current application by Ontario Redimix’s facility in North Etobicoke. | 2019-04-20T22:11:30 | https://www.torontoenvironment.org/ban_on_burning_used_oil_improves_ontario_s_air |
This Exclusive Comic has 2 ORIGINAL Sketches on the Front Cover. It is also SIGNED by the Artist.
This UNIQUE Comic has a REMARQUED Cover with 2 Head Sketches. Both SPIDER-MAN and MARY JANE! It is a BEAUTIFUL, 1-OF-A-KIND Book! Also included is a BONUS J. The item "AMAZING SPIDER-MAN 15 Variant J SCOTT CAMPBELL original art REMARQUED Mary Jane" is in sale since Monday, August 15, 2016.
This item is in the category "Collectibles\Comics\Original Comic Art\Other Original Comic Art". The seller is "hobbiesrus" and is located in Whitehall, Pennsylvania. This item can be shipped worldwide. | 2019-04-26T02:37:17 | http://original-comic-art.net/amazing-spider-man-15-variant-j-scott-campbell-original-art-remarqued-mary-jane.php |
Side carry handle with padded grip that suits most Ocean Kayak boats. Suitable for use on other model/designs or other lifting applications.
Your Inquiry about Carry Handle is Successfully Submitted. | 2019-04-24T00:11:11 | https://www.waves.com.au/carry-handle.html |
Morrisville, N.C.-based Tear- Science Inc., which makes treat- ments for meibomian gland dysfunction (MGD), has appointed a new president and CEO. Joseph Boorady, O.D., joined TearScience from Carl Zeiss Meditec Inc. where he was senior vice president of U.S. sales, marketing, and customer service for all medical products.
Boorady replaces current CEO and co-founder Tim Willis.
ing 36 clinics throughout New York City.
at the ophthalmic technology giant.
The TearScience System, which includes LipiView II, the Korb Meibomian Gland Evaluator, and LipiFlow, is designed to identify, diagnose, and treat MGD, a chronic and progressive disease that disrupts the tear film and vision clarity, causes ocular discomfort and is the root cause of most dry eye.
Bovie Medical Corporation has hired an R&D director to enhance its product development efforts.
The company recently appointed Shawn D. Roman to the role to “further develop and execute”the company’s product portfolio from research through product launch.
Prior to joining Bovie, Roman worked as general manager, co-innovation and, earlier, as an engineering manager at CoorsTek Medical (formerly Innovative Medical Device Solutions). Before that, he spent 14 years with Biomet Microfixation Inc., a business division of Biomet Inc., in several roles, including vice president of Research & Development, director of Development Engineering and senior development engineer.
ties,” Bovie CEO Robert L. Gershon said.
Based in Clearwater, Fla., Bovie Medical Corporation manufactures and supplies medical devices. Its surgical product uses a gas ionization process that produces a stable, focused beam of ionized gas that provides surgeons with greater precision, minimal invasiveness and an absence of conductive currents through the patient during surgery. Bovie Medical also manufactures a range of electrosurgical products and technologies, marketed through both private labels and the company’s own brands (Bovie, Aaron, IDS and ICON) to distributors worldwide. | 2019-04-21T03:00:43 | http://mpomag.texterity.com/mpomag/march_2015?pg=58 |
Wolf Cooktop Repair Caledonia, WI 53108 services all types of Wolf Cooktop Repair, Wolf Gas Cooktop Repair, Wolf Electricc Cooktop Repair, Wolf Induction Cooktop Repair. Racine Appliance Repair will have your Wolf Cooktop repaired or serviced in no time. We will have your Wolf Cooktop up in running in no time. | 2019-04-20T02:30:56 | https://www.racineappliancerepair.com/53108/wolf/cook-top-repair |
Interior Living Room Colors - Blues are cool and usually related with French nation, Victorian or marine outlines. In the more traditional makes use of, blue is marvelous for speaking customized caused by its reassuring nature. In any case, blue proposes incalculable amazing tones that can alternate viewpoint and additionally surroundings. Profit from what you have perused and got the fundamental emotions from greater puts and begin trying out.
There are a few unbelievable specialists who likewise deliver shading counsels to their customers. Ideally, these few guidelines will assist you to to locate your very possess the front room paint colors and get you in your method to making the parlor you had always wanted. | 2019-04-19T08:59:46 | http://www.authorbobodoley.com/interior-living-room-colors/interior-living-room-colors |
Working as a Part-Time Sales Support employee, you must have a strong interest in sales and enjoy working in a fast-paced challenging environment. This is an entry level position that will provide assistance to our customers from our store located at 37420 Cedar Blvd. Ste E, Newark, CA.
o Ability to pass the required drug test (applicable in the US, Puerto Rico, and Guam ONLY). | 2019-04-20T16:14:31 | https://geebo.com/jobs-online/view/id/251122560-sales-support-/mobile/?fd=yes |
BOLTON, MA – Paragon Communications partnered with Independence Solar to install a 1,200 kW rooftop solar array at its Bolton, MA headquarters. The 4,000-panel installation will offset about 50% of the 300,000 sq. ft. building’s annual usage.
Having relocated to their new headquarters in Bolton, MA in 2013, Paragon was looking to expand its sustainability initiatives in a big way while making a solid financial investment. Independence Solar worked with them from the initial project feasibility stage through financing and construction of the state of the art solar facility. The project broke ground in September 2014 and began producing clean energy and savings by the end of the year.
The system is one of the largest rooftop arrays in Massachusetts. Many of the system components were sourced from local suppliers, including the power inverters that were manufactured just down the road in Lawrence, MA.
Paragon Communications Inc. is a market leader in remanufactured electronics, managed services, supply chain and distribution of new and remanufactured technology for the IT and Communications industry. They were named one of Fortune’s One Hundred Fastest Growing businesses, attributing their growth to their customer satisfaction. Headquartered in Bolton, Massachusetts, Paragon occupies a 300,000 square-foot campus stocked with an extensive inventory of recovered, refurbished and remanufactured telecommunications equipment. | 2019-04-20T11:04:50 | https://independencesolar.com/paragon-communications-slashes-energy-costs-independence-solar/ |
Aleon Deluxe International Trunk in Platinum. If you have yet to master the art of packing light, this large 30” spinner suitcase from Aleon’s Deluxe Collection could be the perfect choice for your next overseas adventure. The largest model in the range, it is made from aircraft grade aluminum, equipped with reinforced aluminum corners to maintain shell integrity, and it is fully mobile on silent rolling wheels.
For an added layer of security during transit, the Aleon 30” International Trunk Spinner Suitcase boasts two built-in combination locks approved by the TSA. Resettable with your own memorable code, these tamper-resistant locks secure your belongings when checked into the hold while still granting access to customs officials and security personnel. A height adjustable telescoping handle adds the finishing touch to this extra-large suitcase for business and leisure travelers. | 2019-04-25T18:47:56 | https://www.mosafer.com/brands/brands/aleon/aleon-30-deluxe-international-trunk-platinum-aeo104pto00004.html |
Devout geniuses: which of these early patterns do you believe has the most longevity as the season continues?
EDIT: Whoops, the Union option should've read "... by a ratio of at least 3-1."
I'm going with the homer pick here. RPI may have a tough go of it against Yale for Black Friday, but I believe we'll keep a nice round number in the loss column at the Houston Field House for the foreseeable future.
With that being said, good luck to everyone's team this weekend! All ECAC action next week!!! | 2019-04-24T11:51:17 | https://board.uscho.com/archive/index.php/t-86048.html?s=2fd7337e77b7f2771276ad01a7321664 |
The FBI's Unified Crime Report gathers information from police districts all over the country. As you can see from the chart below, there were 63 property crimes in Blanchard in 2017, of which 25 were burglaries. But you can avoid becoming a statistic when you make the decision to invest in a home security system.
As of 2017, Blanchard had a population of 3,186 people, making it Louisiana’s number 74 largest city. Studies* show that homes with security systems are 3 times less likely to be burglarized than homes without security systems. The smart decision, therefore, is to protect your home with ADT monitored security system.
What Is The Average Loss In A Burglary In Blanchard, LA?
The average loss in a burglary in the United States is $2,416, based on crime statistics compiled by the FBI. That means the total annual loss for Blanchard homeowners is a whopping $60,400! | 2019-04-25T12:25:02 | https://www.homesalarm.com/louisiana/adt-blanchard-la/ |
There are so many Our Generation friends to choose from. Each doll has their own personality and style, and enjoys different hobbies (accessory sets available). OG dolls are available in a variety of hair colours, skin tones, eye colour and ethnicities. You can choose a doll to resemble the child the gift is for, or simply allow them to pick their favourite.
New for 2017 is Blanca the Scientist (from the Professional OG range). A girl with ambition! She has dark hair styled in bunches and brown eyes (that open). OG describe Blanca as Hispanic and she has a darker skin tone. Blanca wears glasses. Standing at 18" (46cm) tall, Blanca is a regular OG girl which means she has a soft body with hard vinyl hands, legs and feet. She is described as non-pose-able, her fixed limbs mean she can stand up and be displayed. Blanca wears her lab coat, a purple skirt, shirt, cosmic themed bow tie, long socks and boots. Accessories include steampunk goggles, glasses, a wind up walking robot, calliper, atom model, pencil and robot spec sheet.
This is a nice quality doll with a friendly appealing face. She is soft in her body so can be taken to bed at night for a cuddle, but her hard limbs mean she can also stand up on her own feet. She makes a great role model for budding scientists. We think it is important that children can choose a doll that looks like them - and OG dolls come in so many different varieties there is a likeness for most children. Deluxe Our Generation Dolls and accessories are also available.
Our Generation is the British version of American Girl. A lot cheaper than flying over to the good old USA to fulfil your daughter's wishlist. The hobbies available from the accessory sets offer a good range of pursuits, from swimming, to fishing, to riding to football. OG girls definitely can! Packaging is made from recycled materials, is 100% recyclable and is printed with soy-based inks. For every Our Generation doll, outfit or accessory you buy, a portion of sales goes to Free The Children's Power of a Girl Initiative to help provide girls in developing countries an education. | 2019-04-22T10:28:26 | https://www.afteralice.co.uk/collections/classic-alice/products/blanca-our-generation-doll-1 |
To address slum and blight conditions in two identified areas of disinvestment, the City of Madison has: 1) defined the boundary, 2) adopted a plan, and 3) selected an agent to facilitate change.
The Downtown Development Authority (DDA), having worked diligently in Downtown Madison since the mid-1980s, is the designated agency to bring opportunity and renewal to downtown fringe and surrounding areas of disinvestment.
The Downtown Urban Redevelopment Plan (URP), the master plan for the DURA, guides property owners, decision-makers, and policy implementation to make change a reality for this area.
The W. Washington Street Gateway, the first focal area for urban renewal efforts, is reaching the tipping point. Acquisition is complete. Blight, nuisance, and hazardous material abatement has taken huge steps. Private owners have had the confidence to restore, rehabilitate, and construct improvements. The subarea's catalyst project - the Central of GA Depot - has had nearly $400,000 in public-private support, resulting in relocation, preservation, reconstruction, and approaching exterior restoration completion. The primary infrastructure project, designed by Georgia Civil of Madison, GA, is underway now, thanks in part to funding by GEFA, City of Madison, and United Bank.
The gateway's Congregate Stormwater Project has already made great strides in improving clean water conditions for Tanyard Branch and will soon serve one-third of Downtown Madison, where current property owners have enjoyed the luxury of not having to install or maintain stormwater facilities in years past. The new infrastructure will address current conditions and also facilitate future development opportunities in the gateway. Congregate stormwater detention can also prove an incentive to investors, as the installation and maintenance of a facility can be more cost effective when shared. Legacy Water Group of Covington, GA, was awarded the low-bid contract and anticipates completion by September 2019. | 2019-04-24T10:46:14 | http://www.madisonga.com/238/Urban-Redevelopment |
La Gaillarde boutique honours ethical fashion!
The event was made even more special with the presence of a few local celebrities, who were gracious enough to be “runway models” for the day, promenading around in the latest Eco-outfits for the crowd. Thanks to: Steven Guilbeault, co-founder of and spokesperson for Équiterre; François Tremblay, environmentalist and columnist for Salut Bonjour!; Émilie and Hugues Fournel, two canoë-kayak Olymptic athletes; Isabelle Lemaire from Jour de la Terre; and Annie de Grandmont from La Gaillarde boutique.
And that’s not all! Six of our very own Cascaders showed up to strut their stuff – thanks go to Claudette Simoneau, Marie-Josée Arsenault, Marie-Eve Chapdelaine and daughter Mélodie, Hong Dung Dang Vu, Karine Jobin and Linda Denis. They were chosen for their long-term commitment to the company and dedication to our core values, which made them the perfect models for our new line of “green” fashion.
The fashion show featured the work of some very talented Quebec designers: Musky, Créations encore, Myco Anna, Voyou, Marie-Josée Bergeron, Louve, Respecterre, Divine recup, Cul de sac, fibrEthik and Oöm.
We hope our Cascades Eco-Friendly Fashion show inspires other large corporations to do the same, and we encourage all consumers to support these forward-thinking fashion designers and labels. Small businesses such as these can thrive only if we support their entrepreneurial efforts, and we are proud to have done our part.
You would like to see more pictures of the show? Click here! | 2019-04-21T07:13:12 | https://blog.cascades.com/2012/10/29/green-light-for-eco-fashion/ |
Would you feign the flu, cancer, or even an STD? Some do it for a living. We’re serious—it’s a real job! Kramer even took a crack at it in an episode of Seinfeld.
With a medical exam room as their stage, Standardized Patients (SPs) are actors who portray characters with a variety of illnesses—and a plethora of personalities—all in order to train med students and other healthcare professionals. But they’re far from being just test dummies or even traditional actors. At the end of their portrayal, SPs are entrusted with evaluating the care they received, which makes them experts at going to the doctor—or at least pretending to.
These professional fakers know how you can perfect your own performance as patients and avoid appointment-destroying pitfalls, so we asked for their advice. See the symptoms of a bad doctor visit and remedy them with these real tips from pretend patients.
The cure: When you’re in an exam room with your doctor, you should be his top patient priority, says Jim Sandloop, a teaching associate and SP at Eastern Virginia Medical School. So speak up. Tell your doc that you understand he may have a lot of other patients. Then add, “But I have some real concerns, so I’d appreciate if you focus on why I’m here today,” Sandloop advises. Your doctor may not even know that he or she is coming across as distracted and distant.
You can also try writing down all your medications, dosages, your last appointments, and even different symptoms or concerns you have before stepping into the exam room, says Valen Treadaway, a third-year SP at the University of California-Irvine Medical School. You’ll speed up the question-and-answer portion of the visit and leave more time for discussion.
The cure: Just because he wears a white coat, it doesn't mean your doctor has the authority to call all the shots. You and your doc make up a team, and should make decisions as one, says Sandloop. So turn a potential monologue into a dialogue. Ask your M.D. to present all options instead of just his opinion.
Then, discuss your immediate thoughts about the information he provided, says Sandloop. You can even pretend you’re speaking to a counselor, and don’t hesitate to share your emotional feelings about a diagnosis or plan of action. Then, you’ll both find the right answers together.
The cure: Go on the offensive and cough up some information, suggests Sandloop. Other than listing the issues you want addressed, offer info about your family history, your home environment, your diet, your exercise routine, and even some aspects of your life that you believe could be affecting your health.
That doesn’t mean you should read about diseases online for hours and attempt to diagnose yourself. But ask questions like, “Is it possible that my stressful new job could be contributing to my symptoms?” Sandloop says. You’ll minimize health factors from slipping by your doc unnoticed.
The cure: Your practitioner should be a bit of a parrot. Ensure that you’re heard by listening for your physician to repeat the information you give him, says Sandloop. That’s your chance to correct and clarify if necessary, but also an opportunity for him to show you he understands. If your doctor doesn’t repeat your speech, ask him to give a conclusion at the end of the visit or even share the notes he took during your appointment. Then you’ll have no doubts about what really registered.
The cure: Sadly, your doctor can’t rub a lamp or tap his stethoscope to magically heal your maladies. But you should leave each appointment with a feeling of achievement, even if that’s simply creating a course of action for the future. Go into your visit and state what you expect to know or have addressed by the end of your meeting, says Treadaway. You may have a few issues that cannot be treated all at once. So reveal the true purpose of your visit and emphasize the most important issues, says Sandloop.
The cure: It’s okay to dump your doc. If you’re not receiving quality care, swap in a new physician. Don’t waste your time with a medical professional that leaves you feeling judged, confused, or disrespected, says Treadaway. All these will make you less willing to be honest with your doctor and will ultimately lead to poorer care. There are a ton of smart and compassionate physicians. Give the, “It’s not you, it’s me” speech and move on.
If you’re interested in becoming a part-time standardized patient, contact your local hospital or health center. Proper training will be offered and previous acting or medical experience typically isn’t required. Start practicing your fake sneeze! | 2019-04-19T10:51:24 | https://www.menshealth.com/health/a19518210/cures-for-bad-doctors-appointment/ |
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Photo of networking and distributed concept.
Image of networking and connection concept.
Image of business district and wireless technologies.
Picture of business district and wireless technologies.
Business district and wireless technologies pic. | 2019-04-26T05:49:03 | https://www.crystalgraphicsimages.com/view/cg2p16174850c/press-enter-button-on-the-computer-business-logistics-image |
John Deere engines and drivetrain components move industries all around you. The same engines and drivetrain components that power John Deere equipment, power thousands of OEM applications around the world. That's the power of John Deere.
Our engines power more than John Deere green and yellow machines. John Deere engines are at the heart of a vast array of machines that perform the work around us. They provide the lifeblood that powers your work.
John Deere OEM engine application capabilities.
A customer testimonial from Puck Custom Enterprises, Inc. who specializes in high performance nutrient handling solutions using pumps powered by John Deere engines.
Chad Pregracke's not-for-profit organization, Living Lands & Waters, is fueling a nationwide environmental movement that is cleaning up America's inland rivers. John Deere is helping propel his work with reliable marine power.
What do you need to know to operate the latest generation of diesel engines from John Deere? As you’ll learn in this video, most of the new systems take care of themselves. John Deere followed a carefully planned approach to meeting Final Tier 4/Stage IV emissions regulations that doesn’t compromise on power, uptime, durability, or ease of operation. We were able to make these advancements with minimal impact on operators thanks to technologies like advanced engine control units and smart exhaust filters that clean themselves using the engine’s natural heat. You’ll also learn about the addition of selective catalytic reduction (SCR), the proper use and storage of diesel exhaust fluid (DEF), and take a look at symbols and controls the machine operator may see during exhaust filter cleaning and SCR operation.
A proven way to get faster, smoother, easier starts during cold winter months, saving you plenty in time, money and engine wear.
We know how the best engines should work because we build them. That's why our approach to meeting Final Tier 4 emissions regulations allows us to focus the performance of the engine's power, efficiency, and responsiveness, rather than just emissions compliance. Learn more at http://www.JohnDeere.com/FT4 or see your local John Deere dealer.
See how John Deere PowerTech™ Final Tier 4/Stage IV engines with the Integrated Emissions Control system offer the right technology for maximum performance.
John Deere's Straightforward Blog (http://bit.ly/hcXSGr ) is your hub for the latest emissions news. This video breaks down the process of regeneration, or "burning off" particulate matter from diesel engines and answers your questions on operator maintenance routine.
Watch this video to learn about the emission technologies that John Deere will use to meet Interim Tier 4/Stage III B off-highway emissions regulations for diesel engines.
Emission regulations are quickly expanding globally. To meet with the individual emission regulation across the globe, Kubota offers industrial engine line-up up to 100HP seamlessly. With the technologies such as cooled EGR, CRS, DPF, and ECU, all are certificated by the latest EPA (CARB) and EU regulations. Spark Ignited engines are also developed as alternative Tier 4 solution with the same footprint and similar performance to diesel engines. Kubota offers solutions for use in every corner of the world. | 2019-04-24T10:25:13 | https://www.drivingsolutions.ch/videos/ |
My name is Manu, I'm from Buenos Aires, Argentina. Professional Graphic Designer trying to get into the world of concept art and illustration.
Any thoughts when looking at it? C&C are welcome :)!
My goal is someday work as a illustrator of magic cards, although sometimes I feel that I'm passionate about concept art too, I love character design!
I´m looking forward to take and give advices on the forum, thanks for reading!
@allnightdesign Welcome! We have "curriculum" tab that gives suggested Level 1,2,3 etc... classes to start with. Hope this helps.
@allnightdesign welcome to the forums!
I'm going to start with that. By the way, I love your work, and thanks for your videos on YouTube, they are really inspiring.
Welcome Manu! Glad to have you aboard! | 2019-04-21T12:52:03 | https://forum.svslearn.com/topic/5504/hi-everyone |
I think it’s only fair that I touch on a few things that for grown ups to enjoy too!
With it’s unique climate, the region is a foodies paradise, and prides itself on top notch dairy, seafood, and of course wine! There are 215 vineyards in the region, with over 95 cellar doors, ranging from farm style to architecturally elaborate, with many offering on site cafes and restaurants.
I hadn’t heard of Wills Domain before, but our friends who we were staying with had been recommended this restaurant by a local winemaker friend…set in amongst rolling hills carpeted in bushy vines, flanked on one side by huge gums, and on the other by grass trees, the view alone is worth the 30 minute drive from Prevelly. Add in beautifully executed mod aus food, and ripper red wines, and you’ll be happy to eat, drink and lose yourself in the view for the afternoon.
We had been to Vasse 4 or 5 years ago, and in the years since they’ve had a face lift. The cellar door and restaurant pavilion is beautiful, with vines and manicured gardens visible at each turn. We were fortunate to have had a fancy wine tasting organised for us…followed by lunch; D E L I C I O U S!!!! You can also have a cheese & charcuterie board/ploughmans lunch on giant beanbags on the lawn downstairs, perfect if you have small mobile types in tow.
The grounds of Voyager are incredible! Rose gardens, perfectly trimmed bushes, row upon row of perfect grapes, immaculate lawns! It is almost worth visiting for the grounds alone…however, the wines are excellent also! And there is so much variety that there is sure to be something to please everyone in your party. We were particularly impressed with their blanc de blancs; bubbly perfection! The restaurant here was on our hit list, but sadly we ran out of time. All the more reason to return!
At the very edge of Margaret River town, next door to the famous bakery, is Swings and Roundabouts Taphouse & Kitchen, and offshoot of the vineyard and cellar of the same name. The food here is rustic, with an emphasis on locally sourced and sustainable produce. Serves are super generous, all the better to share! And share we did! Pizzas, imaginative salads, and tapas styled dishes…we practically rolled out of there we were so stuffed!
It’s not all about food & wine…Mez played golf the whole way across from Sydney; in Port Lincoln, across the Nullarbor (doing the Nullarbor Links), in Esperance and Denmark, and in Margaret River too, at the Margaret River Golf Club. Naturally after the desert course, he was very impressed with the beautiful grounds at Margs, and amused by the local mob of Roos who had obviously seen it all before and were largely unperturbed by Mez and Benny and their efforts!
“Margaret river golf course is an absolute must! It’s a private course but welcomes visitors and Jon and the staff are beyond friendly! Ripping bloke! The course is in mint condition, lush fairways blur into greens on some holes. Few bunkers but plenty of water hazards particularly on the front 9. The back 9 is harder to play because it is sloped in many parts which hurts if you error your tee shot, so if you only play 9, go for the front. Heaps of roos, but that ads something to what is already one of the best country courses in the state. Most importantly, it’s easy to get on. We played N.Y.E with 2 days notice.” Thanks Mez!
Margaret River always looks so beautiful to me – and the food and wine sound amazing! Must put it higher on my list. (Also, I love that grey top!).
Thanks Cristin! Sigh…if only WA were closer, hey? I’d love to have a few months and do it in its entirety!
Looks heavenly! Will have to try Wills Domain wine?! | 2019-04-19T01:13:37 | http://thewindowseat.net/2016/04/margaret-river-wa-part-two/ |
"Tender cherry blossom, sensual white lily and blushing violet petals blended with a hint of warm vanilla."
*Compare fragrance to Japanese Cherry Blossom® by Bath & Body Works.
*Boston Creations, LLC is not affiliated or associated with Bath & Body Works.
WARNING! TO PREVENT FIRE: Warm only with UL or ETL listed electric warmer or unscented tea lights in well-vented classic warmer with min. 2½” top bowl. Never warm on stove or add water. Use as many as desired for use. Once fragrance has evaporated remove from warmer and dispose of properly. NOT EDIBLE. KEEP AWAY FROM CHILDREN AND PETS. NEVER LEAVE A BURNING CANDLE UNATTENDED.
APPROXIMATE MEASUREMENTS (PACKAGED): 4 in. x 3 in. x 1 in.
LISTED PRICE IS FOR ONE (1) PACKAGE OF WAX MELTS PACKAGED AS SHOWN. ONE PACKAGE INCLUDES TWO (2) WAX MELTS.
PACKAGING: Wax melts are packaged in resealable cellophane bags with label. | 2019-04-25T15:12:16 | https://www.boston-creations.com/sweetest-taboo-wax-melt/ |
not how we got there.
in the solution space and try to search the space in parallel.
from different locations to climb up the hill.
problem. You will soon find out that what we mean by interact and evolve.
hence the name Genetic Algorithms, commonly terms as GA.
time, generations become better and better adapted to survive.
improve the overall performance of the complete search space.
A very basic genetic algorithm can be stated as below.
the solution to a few problems through GA.
which steps correspond to what.
check various individuals/ solutions for being better than others in the population.
to get optimal solution given some parameters.
polynomial that best fits the given data.
Let us solve this problem in detail. Consider that the given points are as follows.
optimal solution given these number of iterations on this data.
Inheritance or Crossover, each "Individual" (or "solution") has two parents.
one individual to the tail of the other, as shown in the diagram below.
in general turns out to be a combination of both, i.e., crossover with mutation.
famous books in AI. Its called the Eight Queens Problem.
columns and eight rows as shown below.
We will use the representation as shown in the figure below.
6th row so on till in the 8th column the queen is in the 1st row.
board configuration is given in the diagram on the next page.
Let us quickly go though an example of how to solve this problem using GA.
selected individuals which are the fittest ones according to the fitness function.
Similarly, the mutation step can be done as under.
random position. Hence GA is totally a random technique.
One of the solutions to the problem is shown as under whose fitness value is 8.
The following flow chart summarizes the Genetic Algorithm.
as discussed in the chapter. | 2019-04-25T01:48:40 | http://www.zeepedia.com/read.php?genetic_algorithms_artificial_intelligence&b=2&c=3 |
I remember a few years back when I was consulting with a client that wanted something that was bold and low-maintenance. She didn't like cherry wood and lighter color palettes just wouldn't fly with the theme we were going with. I suggested going with espresso furniture. Her response; "What's espresso?" This prompted me to clear the airways.
Espresso is a color that stands between black and brown. It's really a dark brown that is usually mistaken to be a true black. Many times furniture will be listed as "black" when it is in reality espresso. But you don't have to fret, the difference is so difficult to notice that you can use espresso in place of black furnishings. To be quite honest, it's difficult finding jet black finishes. More often than not, companies advertise espresso finishes as black when they're really not. I'll talk more about true black in a little bit.
Espresso is a very dark brown that appears to be black. It has chocolate tones and in some cases, espresso can have hints of reddish hues in good direct lighting. It gets its name from the coffee. It really does look similar to a cup of dark coffee with light creamer.
Lighting will directly affect the way that espresso furniture looks. In areas like the bathroom, it will look more black than anything. If you place an espresso cabinet in the living room where it will be directly exposed to streaming sunrays, you'll more likely have a chance of seeing the reddish tints and the brown tones manifest themselves.
It's important to consider how you will use the furniture but at the same time, espresso can identical to black furniture. If you're searching for a deep black, you'll need to find something with a ebony finish or a "straight black" finish. These are indicative of true black finishes.
Some people like to stain their cabinets themselves to get just the right tone. You can often find unfinished cabinets that are ready to be painted or stained. This way you don't have to strip and sand them down before you update the finish. This method is obviously more time intensive and will require more elbow grease but it can be a fun activity for those who enjoy hands on and DIY home improvement projects.
Espresso is a very popular finish in 2014 and you should continue seeing it in 2015. It's very modern, chic, and bold. The classic blend is an espresso kitchen cabinet with white quartz tops and stainless steel appliances. You're pulling in the simplicity of minimalism with the common black-white decorating scheme. The stainless steel incorporates a bit of industrialism, making a statement of power and functional use. Finally, the white countertop keeps everything clean, innocent, and elegant.
A few color palettes that contrast espresso well are green-grays, blue-grays, light olive, and mint-green. Espresso is a very dominant color so you want something that contrasts and is almost borderline to becoming an accent color.
I can't leave out the finishing touch; hardware. Hardware is like the icing on the cake, it's the lacing on a beautiful dress, the haute frame to your lenses. Brushed nickel stands out and will complement stainless steel hardware. Another option if you want to tone it down a bit is a bronze finish. You can find oil-rubbed bronze finishes which is basically a polished finish that has a bit more gleam to it.
Espresso is a very versatile color that can be used in many ways. If you're afraid that it won't be black, you shouldn't worry. Unless it will be directly exposed to sunlight, it will work out just fine. | 2019-04-25T15:42:08 | https://dengarden.com/interior-design/What-is-the-Espresso-Color-Used-in-Furniture |
Primarily inspired by Sergei Poliakoff Art works, TERRITOIRE small scale geometry reminds almost immediately of fields viewed from the sky at some altitude. Earth seen from above looks like a wonderful patchwork of intricate fabric embroidered by silken stiches of roads and sparkling from river’s water reflections, shining like embedded diamonds. Digitally printed on 100% linen, this really unique material makes it richer in textures and livelier on hand feel. The 100% linen hand feel conveys a unique airy comfort and freshness. The seasonal mix of cool colours from white to light green, and kaki to light grey blue adds one more layer of peaceful relaxation for the eye. A subtle made to measure bronze kaki braided piping brings a touch of preciousness with its mat patinated golden hue. Simple and sophisticated, casual and yet luxurious.
Discover the TERRITOIRE bed accessories : Throw, bed cover and cushion case.
Bed set TERRITOIRE, 100% Linen with digital print.
Thow with printed pure linen on both sides, piping. | 2019-04-19T22:15:33 | https://www.alexandre-turpault.com/en/territoire-set-13647.html |
If interested please contact Anne Burgess at [email protected] to register your spot.
8:45 a.m. we'll meet at Lowes Building Supply parking lot, in the section nearest 321.
Blowing Rock Gneiss The Blowing Rock Gneiss is one of several 1.1-1.2 billion year old "basement" rocks that are the oldest rocks in the Appalachians. These rocks were metamorphosed and deformed during the assembly of the Rodinia supercontinent and building of the Grenville Mountains (pre-Appalachian). We will see volcanic dikes cut across the Blowing Rock Gneiss that likely fed volcanoes associated with the Grandfather Mountain Formation. THIS SITE IS FANTASTIC FOR COLLECTING as many fresh samples litter the ground just in front of the new road cut and perfect pyrite cubes (<1 cm) abound! 35 minutes; Depart 10:20 am.
Arrive 10:50am STOP 2: Examining the ~740 million year old Grandfather Mountain Formation across Highway 321 from Payne Branch Rd. We'll park in the wide area beside 321, just past the grey utilities boxes which are just a little past the rock cliff.
The Grandfather Mountain Formation includes a diverse suite of rocks that record evidence of a continental rift environment that existed on the eastern North American margin ~745-735 million years ago. The rift formed as a supercontinent, called Rodinia, separated into land fragments that would later rejoin to form the supercontinent Pangaea and subsequently, the Appalachian Mountains. The rocks in this Formation are slightly metamorphosed, yet retain evidence of their original sedimentary and volcanic origins. The now meta-sedimentary rocks were eroded into rift valley basins by river systems and deposited as alluvial fans, ancient floodplains, and even in ancient lakes. Just as the modern East African Rift Valley has volcanoes that riddle the land's surface today, so did the rifted Rodinian valley floors. Evidence of these volcanoes is preserved as lava and pyroclastic flow deposits (some near Foscoe), and as "feeder dikes" aka magma conduits that intruded the crust and supplied lavas to overlying volcanoes. We will have the chance to observe these ancient magma conduits at Stop 4. 30 minutes; Depart 11:20am.
Arrive 11:35am STOP 3: The Linville Falls fault at Apartments at Meadowview. Crystal says there is ample space in the parking lot.
12:10-12:45pm Bring-your-own bagged Lunch @ Clawson-Burnley picnic shelter @ Boone Greenway. Those who are taking only the afternoon field trip can bring their lunch and join us at the picnic shelter, then carpool to Linville Falls.
Arrive 1:30pmSTOP 4: Linville Falls fault at Linville Falls. This will include a short hike to exam the fault at the upper overlook. The fault juxtaposes another 1.1-1.2 billion year old basement rock (the Cranberry Gneiss) atop quartzites of Chilhowee rocks that can be found through out the Gorge. Chilhowee rocks are the youngest of all the rocks we will observe, clocking in at ~565 million years old and represent shallow marine conditions that existed on the North American margin following successful rifting of Rodinia. 1 hour; Depart 2:30pm.
Return to Boone. 45 minutes en-route. Arrive back at Lowes Parking lot at 3:15pm. | 2019-04-21T16:56:29 | https://www.middleforkgreenway.org/events-1/2017/7/10/geology-tour |
Vacancies occurring in the membership of the School Board, including the position of tie breaker, if any, are filled as provided by law.
Legal Ref.: Code of Virginia, 1950, as amended, §§ 2.2-2802,15.2-410, 15.2-531, 15.2-837,15.2-627, 22.1‑39, 22.1-40, 22.1-44, 22.1-47, 22.1-50, 22.1-53, 22.1-57.3, 24.2-226, 24.2-228. | 2019-04-18T12:34:22 | http://www.alleghany.k12.va.us/superintendent/policy_manual/section_b___school_board_governance_and_operations/b_b_e_--_unexpired_term_fulfillment |
Home What is Intel Kaby Lake Processor? What is Intel Kaby Lake Processor?
What is Intel Kaby Lake Processor? | 2019-04-23T10:44:40 | https://www.techawarness.com/2016/08/19/2387/what-is-intel-kaby-lake-processor/img_1794/ |
Danica was 22 when she purchased her salon. She was a hairdresser, a master of the cut and colour, but she felt like she knew nothing about running a business.
10 years later, with 2 small kids, she decided she wanted her business to work for her… but she was feeling like she was on the hamster wheel.
So she decided she needed more direction and reached out to me for help – she realised that while direction was good, she had to do the work to make it work.
Check out at 1.03 where she talks about morale and sales being up, in the first week, doing figures comparable to her previous xmas numbers.
As you would imagine, Danica was super excited about these results.
Now, she’s on top of the financials, and knows exactly where the money goes. She’s able to scale back her hours on the floor and drop back to 3 days a week so she can spend time with her family.
What would she tell herself if she had to do it again? Check out 3.33 in the video. | 2019-04-25T00:42:30 | https://emmagreyson.com/?post_type=post&p=1931 |
Video game statue maker First 4 Figures, who have already produced several SEGA and Sonic the Hedgehog premium collectable statues, have announced a new SEGA character and franchise that they will be adding to their ever expanding SEGA All-Stars collection; Yakuza‘s Kazuma Kiryu.
Teased on their Facebook page, First 4 Figures announced that pre-orders start March 8th, 2016 and featured a peek at Kazuma’s face. Thus far, fan reaction has been mixed. It is cool to see Yakuza joining the ranks of Shenmue and Skies of Arcadia, but they really didn’t nail Kazuma’s likeness. As is, he sort of looks like a cosplayer attempting a Kazuma Kiryu look. In the past, First 4 Figures have taken fan feedback very seriously and have altered character’s faces to better match the source.
We’ll share more details once pre-orders go live on March 8th!
For the past few months First 4 Figures, creators of high quality and high priced Sonic and SEGA statues, have been teasing a Sonic the Hedgehog statue to celebrate next year’s 25th anniversary. Today, on the First 4 Figures Facebook page, the company has shared a concept sketch of the statue and are asking for fan feedback. Those who have followed First 4 Figures in the past know full well that they take feedback very seriously, often making major changes to statues to satisfy fans. The proposed Sonic 25th anniversary statue features Sonic playing a Dreamcast Sonic game on an item monitor. The base appears to be set in Green Hill Zone, much like the first Sonic statue and the 20th anniversary statue were. The reason Sonic isn’t playing a Genesis/Mega Drive? First 4 Figures explained “We thought that as an anniversary piece, we wanted to try and touch on multiple eras in a single piece rather than making it strictly classic. The thought is well received though!”. As for the Green Hill Zone base, First 4 Figures sound open to changing it, as they are aware that that location has been done far too many times already.
After the break, hear my thoughts on the piece and check out the full piece of concept art.
First 4 Figures is asking on Facebook for ideas for the upcoming Sonic the Hedgehog 25th anniversary statue. If you ever had a big idea for high quality Sonic the Hedgehog figurine, then you should probably post it up on their Facebook.
-Classic Sonic is to be the main focus, but don’t let that stop you from including other things from his history such as classic items.
First 4 Figures previously did a 20th anniversary figure that sadly was only available to SEGA employees, this time around everyone will be able to buy the 25th anniversary figure. HA! Take that, SEGA employees!
First 4 Figures have expanded their SEGA All-Stars range of statues with Sonic Team’s NiGHTS, sporting the more recent NiGHTS: Journey of Dreams design. The statue is 12.5″ high and comes in two flavors, the standard edition priced at $209.99 and limited to 1,000 pieces, and the exclusive edition with ambient lighting priced at $234.99 and limited to 500 pieces. Both are due for a Q3 2015 release date and can pre-ordered today!
What do you think of the latest SEGA All-Stars statue? Maybe it’s just me, but I prefer the original Saturn NiGHTS design.
First 4 Figures has teased this image on their Facebook, giving their fans a small taste of whats to come. If you haven’t heard of First 4 Figures, they make high quality video game figures in limited quantities. They dabble in Nintendo, Capcom and of course SEGA figures. I think my personally favorites are their Skies of Arcadia Vyse figure, Beat from Jet Set Radio, Akria from Virtua Fighter 5, and of course Ryo from Shenmue.
Not only are First 4 Figures known for their quality, but they are also known for their high price tags. Don’t be surprised if this figure goes on sale for over $200 dollars.
Last week, First 4 Figures teased a very cool Sonic & Tails Tornado statue which was the second in their Sonic Diorama line. Today, pre-orders have officially opened, and we now have a whole slew of photos, the dimensions, the expected release date, and most importantly – the price! Selling for $299.99 the diorama measures 17.5” tall x 14” long x 14” wide, is limited to 1000 pieces, and is expected to release Q4 2015 (the pre-order page accidentally lists “Q4 2014”). There is also an exclusive version, priced at $329.99, limited to 425 pieces, and featuring the inclusion of LEDs to give the rocket booster a flashing effect.
As you can see in the photos, found on the First 4 Figures pre-order page, the statue is a real beauty and is sure to be a hit with classic Sonic fans. But is it worth the asking price? Are you planning to pre-order the latest diorama? Sound off in the comments section!
First 4 Figures SEGA All-Stars statue line expands to include Jet Set Radio’s Beat – pre-orders now open!
Teased late last week, First 4 Figures have now put their Jet Set Radio Beat statue up for pre-order. Like their Akria Yuki statue, it appears that Beat does not have an Exclusive Edition variant. The statue measures 14 inches tall, and retails for $229.99, limited to 1,250 pieces and due to release Q2 2015. One cool feature is the addition of LEDs which give the illusion of sparks shooting out from his skates as he grinds a rail.
After the break, read the full product description!
First 4 Figures are expanding their SEGA All-Stars line with a Jet Set Radio statue featuring GG’s leader Beat! The rudie with that uki uki waku waku attitude joins the existing SEGA All-Stars line of statues which includes Shenmue’s Ryo Hazuki, Virtua Fighter’s Akira Yuki, and Skies of Arcadia’s Vyse. While Beat’s price is currently unknown, based on past statues in the line it could range from $170 to $200 or more depending on if there is an exclusive version as well. Pre-orders open November 18th, and we’ll likely have all our details then.
What do you think of First 4 Figures choice? What other SEGA franchises would you like to see in the All-Stars line?
First 4 Figures Dr. Robotnik up for pre-order – wait, so it’s not Dr. Eggman anymore?
First 4 Figures is back again with a new classic era Sonic the Hedgehog statue up for pre-order, this time the star is Sonic’s nemesis Dr. Robotnik. Yup, you heard that right, apparently SEGA gave the okay for F4F to use the old name that they’ve pushed aside for the past 13 years. The statue is selling for $399.99 and is expected to release Q2 2015. If the price gave you a small heart attack, F4F has a flexipay option in which fans pay 3 monthly payments – two at $100 and a final payment of $199. The statue is also enormous, measuring 22″ tall, and 19″ wide. F4F also notes “Dr. Robotnik’s package also includes an additional set of hands. As well as the open palms to replicate his signature classic pose, the package includes an additional 2 hands, each holding a Chaos Emerald, in call back to the classic ‘Try Again’ screen at the end of Sonic the Hedgehog 1. These can be swapped out or mixed with the other hands depending on the collector’s preference.” You can pre-order at the official F4f site. Now the question is, what’s next? Classic Amy Rose perhaps?
Regarding the name, while I know many Western Sonic fans grew up with Dr. Robotnik, I do find the decision to be a bit odd. Mainly because I always saw the Adventures of Sonic the Hedgehog and Saturday morning cartoon design to be Dr. Robotnik, while the in-game version had a weird disconnect from the Robotnik name. With Sonic Generations poking fun at the old Robotnik name (“Nobody calls me that anymore!”) and the Jazwares action figures labeling the character as Dr. Eggman, it’s inconsistent with the brand to go back to the Dr. Robotnik name. Ah well, it’s a bigass statue and that’s good enough for me! | 2019-04-26T03:50:42 | http://segabits.com/blog/tag/first-4-figures/ |
Remember our 9 week old puppy demonstrating our three step method for teaching a release while tugging? He’s now one year old with a beautiful understanding of both the release and the “get it”.
In this episode (55:11) We’re back from the 2014 AKC National Agility Championship and sharing our thoughts on the event, the courses, and the results. Mentioned The 2014 AKC National Agility Championship Results and Course Maps Our Preview Podcast Our previous post on the wrap choice in the JWW Round. | 2019-04-20T07:13:01 | https://baddogagility.com/2014/04/ |
Do you remember your childhood fun time with the colorful building blocks? We cherished those joyful moments so much we captured them into our two new tote bags: the classic chic dark grey with a splash of the color cascade and the casual funky color blast. Our generous 15"x15" size will fit loads of your belongings, from the wallet and makeup kit to the laptop and the evening outfit. | 2019-04-23T00:45:25 | https://www.dulgen.com/product/building-blocks-tote-bags |
“A recession proof delight; Exceptional value; Single-handedly inspiring customers with his enthusiasm.” So say the media critics of Jean-Christophe Slowik’s L’Absinthe restaurant.
Opened in November 2007 on Chalcot Road, the French neighbourhood bistro now has a new neighbour, the L’Absinthe Deli and Café.
Jean-Christophe worked with Marco Pierre White for many years and “knew Hansens from the Mirabelle, Belvedere and Frankie’s. They proved very reliable. It is the service you are buying from Hansens and that gives me peace of mind.
“I get on very well with Hansens and once you build that relationship with suppliers, then life is easier. Hansens designed the facilities, came up with good ideas and it has worked very well.
“Hansens always find a way to get the right thing done. We buy all our equipment from Hansens and if we need to look at something, we go to the shop. Their engineer lives locally, which makes it easier to get things fixed…he pops in on his way home.
“When we were refurbishing the restaurant kitchen, Hansens told us honestly what to do with our equipment; whether it is worth fixing or putting in the bin. They recommended induction for the deli kitchen; it does not require ventilation and that saved aggravation and money.
Valera induction hobs, built into tables and neatly suited up to the wall and adjoining equipment. Valera induction is reliable, well-built and provides great value for money. The same can be said of Valera’s deli-counters, with added good looks. | 2019-04-23T08:03:09 | http://www.hansens.co.uk/2012/04/l-absinthe/ |
The ClickDimensions Service Protection feature ensures that our customers receive high deliverability rates by preventing emails from constantly being sent to bounced email addresses. In this blog post, I will show you how to create a bounce notification system using CRM workflows to alert you or your team members whenever one of your recipients has received a hard bounce. Receiving these automatic notifications will make it easier to keep up with the contact and lead records who have now been blocked by the ClickDimensions solution.
First, go to Settings > Processes to create a new workflow process. Make sure Email Event is selected in the Entity field.
Next, in the workflow’s Information window, be sure to change the scope of the workflow to Organization and ensure that the workflow starts when a record is created. Navigate down the page to the Steps view and click the Add a Step drop-down menu. Select Check Record.
Open the Check Record step and check for the following email event types in the newly created record: DNS Failure, Invalid Recipient and Generic Bounce: No RCPT. Then save and close.
After adding the settings for the Check Record step, add a new step for sending an email. Open the settings for the Send Email step. Here you will want to edit your notification email to display certain information from the new email event record. You can customize the message however you like, but at the bare minimum, you will want four dynamic values to populate in the body of the email: the email event type, the email event lead, the email event contact and the email address associated with the email event.
Now you will begin to receive your block notifications.
Disclaimer: this type of workflow could impact system performance. Once activated, a workflow like this can consume many resources depending on how many emails you send regularly, as the workflow will check every newly created email event record. Each email sent creates at least one email event record.
You could take the workflow built in this blog one step further by having the workflow place blocked emails in a particular marketing list after receiving the hard bounce notification, so you can maintain in one place all of the email addresses that will no longer receive ClickDimensions emails. | 2019-04-24T12:12:28 | http://blog.clickdimensions.com/email-event-hard-bounce-alert/ |
This individual leads the planning of multiple complex PF NPD project initiatives. Also, develops and maintains post Launch portfolio reports, provides insights into NPD capabilities and necessary improvement to Senior Management. Manages data integrity in project database and ensure OneNote project management is being actively managed for their project areas. Ensures timely communication with project stakeholders (including Senior Management) and works proactively to identify potential issues and/or conflicts.
30 % – leads development and management of project schedule per information provided by Key PF project teams. Leads commercialization planning. Ensures documentation is created by the team as appropriate (One note project plans, gate documents, meeting minutes, etc.). 15% – Advises business and technical leads of project risks – schedule or resources and provides alternatives to address risks, including suggesting options to keep projects on track 10% – Manages the gate meeting agendas, ensures project teams are prepared for gate meetings, takes meeting minute. 20% Proactively Identifies commercialization improvements and recommends changes to Senior management. Ensures timely and effective implementation of improvements 20% – Develops and manages BU Monthly Post Lunch reporting, including prioritization, post launch, and portfolio. Leads conversations with Senior Leadership on portfolio insights and actions.
Can leverage technology to provide solutions to process understanding and needed improvements. Finds new ways of working better (process improvements), and has the fortitude to implement.
Can facilitate an open dialogue with Senior Management where conflicts about project risks and priorities can be discussed and resolved in an objective and timely manner.
Works with the project teams to keep track of all relevant work streams for new product initiatives, changes to existing product lines, capital projects, label changes, process improvement, etc.
Is comfortable in the role of ‘change agent’ in an environment of culture change.
Requires a BA/BS. PMP certification preferred.
Strong IT skills and self-starter using technical problem solving capabilities. Excellent Microsoft Office skills, especially Excel and Project or similar tool.
Ability to interpret and adjust to situations that involve conflicting goals.
Demonstrates competence in risk management and the achievement of targets.
Ability to effectively communicate with different functional areas and levels (Including Senior Levels) within the organization. | 2019-04-22T00:42:25 | http://careers.campbellsoupcompany.com/job/9432639/business-program-lead-norwalk-ct/ |
Silicon Motion Technology Corporation (NasdaqGS: SIMO) is a global leader and pioneer in developing NAND flash controller ICs for solid-state storage devices and specialty RF ICs for mobile devices. We have the broadest portfolio of controller technologies and solutions and have shipped over five billion NAND controllers, more than any other company in the world.
Our key products are controllers used in embedded storage products such as SSDs and eMMCs, as well as in expandable storage products such as memory cards and USB flash drives. Our products are widely used in consumer devices such as smartphones, tablets and PCs and for industrial, enterprise, commercial and other applications. Our customers include most of the NAND flash makers, leading technology OEMs, and the majority of storage device module makers. More NAND flash products - especially next-generation flash - produced by Intel, Micron, Samsung, SanDisk, SK Hynix and Toshiba are supported by Silicon Motion controllers than any other company. We are the world's leading merchant supplier of controllers for eMMC embedded memory used in smartphones and tablets, and the leading merchant supplier of controllers for client SSDs used in PCs and other applications. Our Shannon Systems enterprise-grade PCIe SSDs are targeted at the Chinese hyperscale data center market. For the mobile communications market, our key products are mobile TV SoCs and RFICs. We market our controllers under the "SMI" brand, our enterprise-grade SSDs under the "Shannon Systems" brand and mobile communications products under the "FCI" brand.
We were founded in 1995 in San Jose, California and now operate from corporate offices in Hong Kong, Taiwan and the US, with design centers and sales offices in Taiwan, Korea, China, Hong Kong, Japan and the US.
To become the world's leading supplier of ICs for mobile storage and mobile communication solutions!
We are steadily developing and concentrating on our foundation business, constantly striving for the best. We develop business with a practical attitude and execution to achieve excellence in all our chosen fields.
Establishing integrity as our business operation base, we develop honesty, trust and mutually respectful partnership with our customers and employees.
We strengthen our corporate core competencies by continuous innovation, setting ourselves as a benchmark while endeavoring for excellence.
At Silicon Motion, we treat our employees as the foundation of our success. While respecting varied thinking, we emphasize consensus to build up an efficient work environment. In this fully-authorized environment, our employees can explore their abilities, potential, and creativity to their utmost, creating three-way success among our employees, shareholders, and customers. | 2019-04-21T17:11:44 | http://www.siliconmotion.com/hr/A7.1_About_Silicon_Motion.php |
Founded more than 20 years ago, Cafe Campesino is Georgia's first and only 100% Fair Trade, organic coffee company. The idea for Cafe Campesino was born out of conversation with a Guatemalan coffee farmer who explained the coffee farmer's perspective to company founder Bill Harris during a Habitat for Humanity volunteer trip. Since that enlightening conversation, the Golden Rule has been central to the company's business model: do unto others as you would have done to you. As a result, Cafe Campesino has maintained direct trade relationships with small-scale, organic coffee farmers for more than 15 years in countries such as: Colombia, Ethiopia, Guatemala, Honduras, Mexico, Indonesia and Peru.
Based in Americus, Ga., Cafe Campesino roasts the green coffee it receives from farmer groups and sells to coffee shops, grocery stores and individual consumers across the United States. It also operates Georgia's first Specialty Coffee Association Premier Training Campus in Americus where coffee professionals and home-users come to learn about brewing and preparing coffee beverages.
Cafe Campesino also also operates a coffee shop and restaurant in Americus where made-from-scratch breads, baked goods, lunches and breakfasts delight out-of-towners and locals alike. It is located at 134 West Lamar Street in historic downtown Americus across from the Windsor Hotel.
Truly a Georgia-grown business, Cafe Campesino invites you to join them for a cup of life-changing coffee.
Monday - Friday: 7 a.m. - 6 p.m. Saturdays: 8 a.m. - 4 p.m. Sunday: Closed Lunch Served: 11 a.m. - 3 pm. | 2019-04-21T04:40:56 | https://www.georgiagrown.com/members/profile/cafe-campesino |
Product: (1) pound (454g) of Dried Atlantic Fish Maw. One pound would have (15-20 pieces).
Packaging: Packaged 1lb per bag and a gift bag is included.
Health Benefit: Fish maw is a great source of collagen and protein. It is commonly used in Chinese cuisine due to its impeccable source of nutrition. | 2019-04-19T00:29:08 | https://royaljubilee.net/collections/custom-collection/products/1lb-dried-atlantic-sea-cucumber-s-1lb |
Parachute cord (also paracord or 550 cord when referring to type-III paracord) is a lightweight nylon kernmantle rope originally used in the suspension lines of parachutes. This cord is useful for many other tasks and is now used as a general purpose utility cord by both military personnel and civilians. This versatile cord was even used by astronauts during the 82nd Space Shuttle mission to repair the Hubble Space Telescope. The braided sheath has a high number of interwoven strands for its size, giving it a relatively smooth texture. The all-nylon construction makes paracord fairly elastic. Current technical standards for the manufacture of cord for use in parachutes are published by the Parachute Industry Association. The US military MIL-C-5040H standard required the material to be nylon. Similar styles of cord are manufactured with other materials such as polyester. | 2019-04-20T20:58:01 | https://www.sparks-military.com/en/camping/291-550-cord-nylon-parachute-cord-400-yards.html |
Comfort participation safari - the tour leader will shop and prepare meals and group participation in camp chores is required but limited.
No compulsory inoculations required, however please consult your specialist travel doctor for information to suit your individual needs.
This tour may be extended to visit the Kalahari Desert, the Okavango Delta and the vast salt pans of Makgadikgadi - see trip details for Cape To Vic Falls Grand Explorer, tour code CVa21.
Tour highlights This tour follows the same itinerary as the Cape Town to Victoria Falls Grand Explorer but stops on the 13th day in Windhoek - please see tour code CVa21 for the detailed itinerary.
Cape Town is one of the most picturesque cities in the world, with the majestic Table Mountain providing its central focus. Departing, after a tour briefing, from Cape Town at 08:00am we visit Hout Bay harbour en route to Cape Point Nature Reserve and then the African Penguin colony at Boulders Beach. We sample some of Cape Town’s culinary wonders at a local restaurant in the Victoria & Alfred Waterfront (own expense).
The Cederberg is a massive rock wilderness with giant sandstone boulders that have been sculpted by wind and rain into bizarre and artistic shapes. We head north to the Cederberg and explore the rugged landscape on foot before relaxing in chalets for the evening.
We make our way into the more arid regions and upon entering Namibia, we stay at a lodge on the Gariep River. Namibia’s southern border river flows quietly and peacefully and the river valley is hardly affected by tourism. The riverbed is sandy, the water clean and clear. Time free for swimming and relaxing or you can venture down the river in canoes (own expense).
The Fish River Canyon, situated along the lower reaches of the Fish River, is one of the most impressive natural beauties in the southern part of Namibia. With its depth of up to 550 metres, the Fish River Canyon is the second largest canyon in the world. We make our way to the canyon and in the afternoon watch a spectacular sunset as the sun slips over the canyon’s rim.
Swakopmund is a popular seaside resort with a slightly nostalgic atmosphere, characterized by numerous colonial buildings. In terms of flora, both the Welwitschia Mirabilis and the Kokerboom grow on the stony plains of the Namib and many beautiful specimens surround this coastal town. Swakopmund is also the adventure activity capital of Namibia. Day free to explore the town or try dune boarding or sea kayaking (own expense).
Namibia is a land of great contrasts and Damaraland demonstrates this with stark plains, petrified forests and ancient valleys leading to rocky outcrops and the soaring peaks of the Brandberg Massif Mountains.
Once a vast lake fed by the Kunene River, the pan that is Etosha NP dried up thousands of years ago when the river waters chose a new course. Etosha is big game country. We take game drives around the huge pan to find the elephants, herds of antelope and lions around the waterholes. We stay at a lodge on the outskirts of the national park.
This pretty town, beautifully situated in a valley, combines the architecture of a modern city with numerous buildings in the style of the German colonial era. The charm of the city of Windhoek lies in its harmonious blend of African and European cultures and the friendliness of its people. We visit the cosmopolitan capital and enjoy a restaurant meal (own expense).
Tour ends after breakfast this morning. | 2019-04-23T12:37:00 | https://www.swagmantours.com.au/tour-details/?overland-cape-town-to-windhoek-grand-explorer&c=CWa13&d=overland |
Tell us what you think about 32.768kHz Clock Crystal Cylinder Quartz 100 pcs, share your opinion with other people. Please make sure that your review focus on 32.768kHz Clock Crystal Cylinder Quartz 100 pcs. All the reviews are moderated and will be reviewed within two business days. Inappropriate reviews will not be posted. | 2019-04-21T07:14:37 | http://www.satistronics.com/32768khz-clock-crystal-cylinder-quartz-100-pcs_p2177.html |
Bassett joins Canberra United after a stellar European Championship's campaign with the English National side, and said she can’t wait to get started in Canberra.
“I'm so excited and I am really looking forward to meeting all the staff and players at this ambitious club," she said.
“I will gladly be passing on knowledge, experience, advice and all that I can do to support the younger players. | 2019-04-19T17:19:59 | https://www.w-league.com.au/news/canberra-secure-english-international-defender |
If you're looking to discover somewhere new, look no further than Levín. Whether you're planning to stay for a night or for the week, the area around Levín has accommodations to fit every need. Search for hotels in Levín with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all Levín hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Levín hotel deals are here with our lowest price guarantee. | 2019-04-19T12:20:26 | https://www.hotels.com/de11063748/hotels-levin-czech-republic/?pos=HCOM_US&locale=en_US |
Part of the 40/40/20 rule of direct marketing is knowing who your audience is and being able to target that audience with your direct mailers. This will save you a lot of money and increase your return on investment. Building your own list can be tedious and unscientific at best; and it’s easy to get scammed by online companies selling dirty lists full of false leads that cost you a lot of money.
Another tried-and-true tenant of the 40/40/20 rule of direct marketing is the value-added promotion. You’re wasting your money if your direct-mail marketing promotions don’t include sales, rebates or bonuses. The key is to give your audience a reason to purchase now, so make your offer truly unique and big enough to provide great value to your customers without breaking your budget. Make the offer time-limited to maximize your return on investment and have prospects redeem a coupon or offer code so you can measure your campaign’s success.
Having a great design that stands out and also works to reinforce your message is essential to direct-mail marketing success. Make sure you follow basic design rules, but don’t be afraid to get creative. If you don’t have the software or inclination to create stunning professional designs, hire a graphic designer. The credibility that a professional design lends to your direct-mail marketing materials is well-worth the investment.
Find a printer with a reputation for quality and customer service, and order a sample kit. Most companies will send you samples free of charge so you can see the quality of their finished materials firsthand. Pricing should not necessarily be the determining factor. In the printing world, you often get what you pay for and your company will not benefit from sending out direct-mail marketing materials with streaks or poor color quality.
Most reputable printing companies have a mail house, or partner with mail houses, to deliver your direct-mail marketing materials. This can save time and money, because your mailing list can be addressed as the materials are printed. You won’t have the extra costs associated with shipping your materials from one place to another before actually mailing them to your prospects. What’s more, good printing companies are knowledgeable in printing regulations and postage pricing, so they can get you the best deal possible on bulk mailings.
Great promotional copy identifies with the target audience through features and benefits. For instance, it’s not enough to simply say that a pair of sunglasses has 100 percent UV protection (the feature). You have to tell your audience that this will save their eyes from the sun’s harmful rays (the benefit). Many features have multiple benefits, and a good copywriter will pick them out. You must also motivate prospects through a call to action, which directly relates to your great offer. If you’re having trouble writing your own copy, your return on investment could be boosted by hiring a professional.
Will your audience respond better to a postcard, brochure, greeting card or sales letter? What emotions does the subject matter invoke? Choosing the right medium for your message’s delivery is as important as the message itself; and pulling it off in a professional and creative manner is even more essential. Consider using professional-grade paper and die cuts to shape your materials to help them stand out from the crowd, and perhaps a touch of gloss to earn instant credibility and long-term brand recognition.
Take a step back from your direct-mail marketing efforts and approach them as your prospects. How would you react to your materials? Is the offer strong enough? Does the brochure/postcard/flyer look credible? Do you just have to possess what they’re selling? Now, run it by friends, family members, co-workers and even passers-by to get their honest reactions. If you can’t convince them, you need to tweak your campaign.
Many companies have wasted a lot of hard-earned marketing dollars, because they didn’t test the market. Before you launch a full-blown direct-mail campaign, you should always test against a smaller market to determine your rate of return. If you can’t make sales off a small portion of your target audience, you’re not likely to realize much more success with a larger demographic. Many companies even weigh different campaigns against one another, but if you don’t have the budget for that just remember to start small and make tweaks as necessary.
This is another oft-ignored policy that can yield huge dividends. Following up with your prospects can snag a large number of sales in a short amount of time. The more personal you can make it, the better. Try following up a postcard with a brochure or sales letter personalized to the recipient (your printer can do this for you). A phone call could also be warranted, as long as it’s appropriate. Try collecting phone numbers and permission to call with more information as part of your call to action and offer to get the highest-quality leads for your follow-up. | 2019-04-21T14:52:20 | https://salesleadsunlimited.us/direct-mail-tips/ |
This meal will be easy, creamy, mild and flavorful from the spectrum of Indian curries. I take advantage of poultry drumsticks it but you can also use chicken breasts to make this because I love the taste of.
The one thing you do not would you like to hurry within this butter that is easy meal could be the caramelizing associated with onions its a very essential covering of taste in just about any Indian curry, and particularly in a sweeter any like this.
The dish was had by me with many vegetablepilau grain. It a lighter red if you want the sauce to be thicker, add some more tomato paste and more yogurt will make. You are hoped by me love this particular meal.
Bundle all foods in a zip-top shallow or bag baking plate, rubbing the marinade to the poultry. Leave remain at room-temperature, or marinate when you look at the refrigerator immediately and toss all of them from inside the bake and oven at 350 grade.
Temperatures oils over moderate temperatures in a saucepan that is large. Incorporate onions and gradually prepare until fantastic, about twenty minutes, decreasing temperatures if they're acquiring crispy or browning easily. Incorporate garlic and prepare until aromatic, about 1 instant. Blend in garam masala, paprika, cinnamon, and sodium; prepare 1 instant considerably. Incorporate tomatoes and peppers that are green prepare 2 moments, subsequently very carefully puree using a standing blender.
Return sauce to saucepan, add yoghurt, ketchup, tomato insert, and soya sauce and provide a-simmer. As soon as the poultry may be out of the range, be sure it is becoming done well. Incorporate poultry on the sauce, address, and simmer over medium-low temperatures until prepared through about ten full minutes. Provide spread with cilantro, if ideal. | 2019-04-18T15:05:57 | https://clarkspicks.com/easy-and-yummy-butter-chicken-with-rice/ |
Established 2013, Gary Mungall Joinery provides a professional and friendly service, based in Falkirk covering work throughout Central Scotland – including Stirling, Grangemouth, West Lothian & Fife. We cover all aspects of joinery at competitive rates whether you are thinking of a new kitchen or home improvements, there is no job too big or small. We offer a free no-obligation quotation and advice to all of our customers and Gary will personally measure your job and discuss and answer any questions you may have.
With over 20 years’ experience in the joinery trade we offer a wide range of Joinery Services from fitting kitchens, hardwood, laminate, engineered flooring and fitted wardrobes to your specification. We also offer bathroom fitting, wet walling, tiling and much more.
We have an ever increasing list of happy customers, who ask us back, most of our new customers come to us through recommendations from friends and family. These recommendations are as a result of the care and attention that we use when working in your home. All of our work is completed to a high standard and we believe in providing a great service.
Feel free to have a look at my portfolio of completed work.
Contact us now to arrange your free no-obligation quotation. | 2019-04-26T16:46:14 | http://www.garymungalljoinery.com/index.html |
The "Public Input" segment of the Business Advisory Board (BAB) meeting is provided for the purpose of permitting persons to present specific matters to the Seminole County Public Schools BAB for its consideration and referral to the Superintendent and staff for inquiry and action as appropriate or address specific items. The public input segment of the meeting is not open to presentation of campaign issues by political candidates or others, student disciplinary actions, pending employee disciplinary matters, or pending litigation. A form is provided at the BAB meetings or you can download the form here. | 2019-04-19T19:35:38 | https://www.scps.k12.fl.us/community/business-advisory-board/public-input.stml |
• 15/6/2002 Meeting For Skin Melanoma. Organized By The Medical Company Of West Greece And The Clinic Of Plastic Surgery Of The General Hospital Agios Andreas. Patras, Greece.
• 21-22/6/2002 3rd International Seminar of the Hellenic Society of Arthroscopy and Knee Surgery with Workshop in Cadaveric Knees and Shoulders. Athens, Greece.
• 23-26/8/2002 18th Seminar in Microsurgery of the Orthopaedic Clinic from University Of Ioannina, 40 Hours of Training in Rats. Corfu Greece.
• 27-30/11/02 17th Hellenic Congress of Rheumatology.
• 15-17/11/02 8th Seminar in Biomechanics of the Spine. Organized By The Hellenic Orthopaedic And Trauma Society And The College Of Greek Orthopaedic Surgeons. Marousi, Athens.
• 15-17/5/2003 International Symposium in Musculoskeletal Infections. Orthopaedic Clinic, Medical School Of Larisa, Larisa, Greece.
• 14-16/6/2003 Seminar in Shoulder and Elbow Injuries with Workshop. Orthopaedic Clinic, Medical School Of Patras, Patrai Greece.
• 20-22/6/2003 4th International Seminar of the Hellenic Society of Arthroscopy and Knee Surgery with Workshop in Cadaveric Knees. Nauplio, Greece.
• 15/11/2003 Meeting For Shoulder and Elbow Arthroplasty. General Hospital Asklipeiio Voula. Athens, Greece.
• 14-16/11/2003 Seminar for the Indications and the Use of the Ilizarov System, With Workshop. Pallas Building, Kiffisia, Athens.
• 27-30/11/2003 International Symposium for Prevention and Therapy in Sport Injuries with Workshop. Orthopaedic Clinic, Medical School Of Larisa, Larisa, Greece.
• 6/12/2003 Meeting For Injuries of the Acl. General Hospital Asklipeiio Voula. Athens, Greece.
• 11-13/11/2004 2nd Three Days Educational Meeting for Resident Doctors. Organized By The Hellenic Orthopaedic And Trauma Society And The College Of Greek Orthopaedic Surgeons. Marousi, Athens.
• 19-21/11/2004 Annual Meeting of the Greek Department for Knee and Hip Arthroplasty. Nimts Hospital, Athens.
• 20/11/2004 Meeting On Knee and Shoulder Arthroscopy. General Hospital Asklipeiio Voula. Athens, Greece.
• 26-28/11/2004 Seminar about Complications in Orthopaedic Traumatology. General Hospital Of Tripoli. Tripoli, Greece.
• 2-4/12/2004 International Symposium “What Is New In Treatment of Knee Injuries and Diseases” With Workshop. Orthopaedic Clinic, Medical School Of Larisa, Larisa, Greece.
• 18-20/2/2005 2nd Seminar about the Use and Special Techniques of the Ilizarov System, With Workshop. Orth. Dep., Athens Medical School, Attikon Hospital, Athens.
• 19/3/2005 Day Training Course on Arthroscopic Techniques for Acl Reconstruction Using the Buttonhole Soffix System. Orthopaedic Clinic, 401 General Army Hospital of Athens.
• 20-21/1/2006 Annual Meeting of the Greek Department for Intramedullary Nailing, Organized by the Hellenic Orthopaedic and Trauma Society. EKEFE Demokritos, Athens, Greece.
• 10-11/2/2006 Symposium on the Use of MRI and Ultra Sound for the Sport Injuries of the Knee and Shoulder with Workshop. University of Ioannina, Medical School, Ioannina, Greece.
• 4-8/10/2006 62th Hellenic Congress of Orthopaedic Surgery and Traumatology. Athens Hilton. | 2019-04-18T20:51:42 | http://www.kouloumentas.gr/conferences.php |
Najib arrives at the Kuala Lumpur High Court.
KUALA LUMPUR - Disgraced former Malaysian prime minister Najib Razak has been out in recent weeks campaigning as if for an election, trying to shed the image of a wealthy, elite politician and elicit public sympathy before his corruption trial begins next Tuesday (Feb 12).
The trial starts nine months after Malaysians voted Najib out of office in a general election dominated by public disgust over allegations some US$4.5 billion (S$6.1 billion) was stolen from 1MDB, and about a quarter of it went into his personal bank accounts.
Police found nearly US$300 million worth of goods and cash at properties linked to Najib soon after the May 2018 election.
The 65-year-old son of Malaysia's second prime minister is also trying to build an image as a folksy voice of working people, especially members of the ethnic Malay majority.
Najib, in a viral video last month, crooned a Malay-language version of the 1970s hit Kiss And Say Goodbye, surrounded by a chorus of sombre young singers, criticising Mahathir's coalition for failing to live up to election promises.
"On May 9, 2018, I was ousted. All this time, I have been fighting with my life for the people I love. But what can I do?" an earnest Najib says of his "saddest day" in the introduction to the song.
Najib has also been hitting out online. His jibes against ruling party politicians on Facebook and Twitter have some social media users referring to him as "King of Trolls".
A relaxed, casually dressed Najib also paid a visit this month to Langkawi, Mahathir's island constituency, where he pottered around town, visiting markets, eating at hawker stalls and rubbing shoulders and posing for selfies with passers-by.
Mahathir was not impressed. He told a news conference last week Najib seemed to be getting popular on social media because "he provides a lot of stories".
Harvinderjit Singh, one of Najib's lawyers, declined to comment on the former premier's public appearances but said the 1MDB trials were unlikely to be affected by the hoopla.
"The case is going to be determined by what happens in court, not out of it," he said.
While Najib has been trying to build public support, the Attorney-General's Chambers (AGC) has been building a formidable team to prosecute Najib, his wife and a host of other former top officials charged for corruption. All of them have pleaded not guilty.
The prosecution has been recruiting top-notch criminal attorneys including former federal court judge Gopal Sri Ram and Sulaiman Abdullah, a lawyer with a background in cases of white-collar crime.
Seven of those charges will be the subject of Tuesday's trial, relating to transfers totalling RM42 million (S$14 million) into Najib's personal bank account from SRC International, a former 1MDB unit.
Prosecutors have handed nearly 3,000 pages of documents to the defence ahead of the trial, said Najib's lawyer Singh.
"Our client is of the view that if he gets a fair trial, then the truth will show itself to the public," he said. | 2019-04-22T08:05:54 | https://www.asiaone.com/malaysia/malaysias-ex-pm-najib-gears-graft-trial-charm-offensive |
If I had grown up playing a guitar, singing and writing songs instead of newspaper stories or blog posts, maybe I could have been more like Andrew Landers.
We had a chance again over the weekend to watch him perform at Contrary Brewing Co. in Muscatine. Andy, who has been writing and performing for nearly 20 years, and his band, The Mainstreet Struggleville, won the 5th Annual Jammin’ Challenge sponsored last year in Seattle by Seattle Wave Radio and the Hard Rock Cafe. They bested thousands of other entries in the contest.
Andy and his family live in Olympia, Washington, but I first became aware of him nearly a decade ago when they lived in Muscatine. Because of my old job, I heard more than I needed to know (or will share here) about Andy’s leaving Muscatine with his family. He’s a pretty spiritual guy and refers to that time in his life as walking through fire or across glass on his hands and knees. And he writes and sings about it.
Having gone through my own fire — job loss, divorce, loss of friends and other disappointments — I really admire Andy. Watching him now, it’s clear he is doing what he was meant to do. The lesson I take away from his example is that the best path to take in life is to pick up and dust off yourself when you get knocked down, never give up and put your faith in a higher power.
Your reward just may be winning a contest at the Hard Rock Cafe. Or getting a chance to sit on the 35th floor of a downtown Chicago office building, listing to a successful attorney’s story of how Loras College contributed to the success in his life. Or you just may find the love of your life and the life you always wanted.
This blog came to life in 2012 after I had been downsized out of a job, which felt at the time like the blackest time in my life. Many good things have happened since then, however. Good things that could have never happened without the experience of first going through the bad times. Things that were absolutely unimaginable to me four years ago.
Life is sometimes a struggle. You just have to keep picking up and dusting yourself off to make the struggle worth it. I’m glad Andrew Landers is out there spreading that message with his music. | 2019-04-25T20:26:52 | https://bromehill.com/2016/07/19/the-struggle-is-real-and-worth-it/ |
Fashionable, dainty and beautifully floral. This amber ring features a bright, classic amber gem and a fully adjustable, sterling silver band.
This fashionable amber ring is rather spectacular. The detailed silver band features a number of dainty flowers, which beautifully compliments the natural baltic amber stone. The Amber piece boasts a classic Amber hue, with a bright orange saturation. The floral band sits beautifully adorning your hand, from day to evening wear - this is a perfectly versatile accessory.
Love this minimal floral style? Check out the same design in Red Cherry,Gorgeous Green & Beautiful Butterscotch. | 2019-04-22T20:02:42 | https://balticbeauty.co.uk/products/amber-floral-ring |
It"s Mine - The white-collar thief strategy game!
Recruit the most bizarre gang of crooks ever, stuck-up aristocrats, eccentric chefs, spunky pick-pockets, nonchalant mime artists, little rascals and quirky aged divas. And then take over the Sagrada Familia, Notre Dame, Big Ben, Cappella Sistina and other popular locations from Barcelona, Paris, London and Rome.
It is a 2-player card game played in six rounds with a colorful and minimalist design that combines card drafting, set collection and majority mechanism.
- Art by Ivan Chacón.
- Simple rules but deep gameplay.
- 110 cards: 28 District cards, 25 Boss cards, 54 Action cards and 1 round/scoring track card.
- 5 white wooden cubes.
- 32 page rulebook including Spanish and English. | 2019-04-23T22:43:48 | https://www.gunzone.dk/strategi-spil-2078/its-mine-p39497 |
Its always please to find a great copycat recipe. You can mix your frugal pantry and refridgerator ingredients and brings home your favorite snack. Mimic the Starbucks Egg Salad Sandwich for a fraction of the price – you might even be able to make a sandwich for the entire family for less than you would pay in the store!
Thanks for sharing! I’ve never had Starbuck’s eggsalad sandwich but I’m going to make this!
This Egg Salad Sandwich will be delicious. Thanks so much for sharing this awesome recipe with Full Plate Thursday. Hope you are having a great weekend and come back to see us real soon! | 2019-04-24T23:45:08 | https://www.frugalcouponliving.com/copycat-starbucks-egg-salad-sandwich-recipe/ |
1) NEW WEBSITE – Global Research TV: its Homepage, About.
2) upgrading the Center’s presentation.
The Centre for Research on Globalization (CRG) is based in Montreal, Canada, and is a registered non-profit organization. The CRG is a fully independent research and media group of writers, scholars, journalists, filmmakers and activists. It publishes a webpage containing news articles, commentary, background research and analysis on a broad range of issues, focussing on social, economic, strategic and environmental processes … (full text about).
The Global Research webpage at CRG based in Montreal publishes news articles, commentary, background research and analysis on a broad range of issues, focussing on social, economic, strategic, geopolitical and environmental processes.
Our website was established on the 9th of September 2001, two days before the tragic events of September 11. Barely a few days later, Global Research had become a major news source on the New World Order and Washington’s “war on terrorism”.
During the war on Iraq, Global Research published, on a daily basis, independent reports from the Middle East, which provided an alternative to the news emanating from the “embedded” journalists reporting from the war theater. Several Global Research authors have received awards for their writings. In 2005, two Global Research authors have received the “Project Censored Award”, University of California at Sonoma.
Numerous universities, libraries and research institutions have established a link to Global Research on their respective web sites.
Global Research is classified by Alexa (the web-ranking organization), as The Number One Globalization Site. In early 2006, Global Research had more than 15,000 unique visitors per day.
Global Research has received for four years in succession, the Goodwriters Democratic Media Award, classified among the best 80 alternative news sites. | 2019-04-19T06:30:52 | http://blog.world-citizenship.org/wp-archive/419 |
This morning, I woke up to news that this blog - wwww.zuzeeko.com - has been chosen as a noteworthy blog on the Blogger.com network and showcased by the blogger team on blogger's Blogs of Note.
Blogs of Note is a blog that showcases noteworthy blogger blogs on a daily basis. It replaced blogger's "Blog to the Week." In fact, the blogger team describes it as a blog that highlights "interesting and noteworthy blogger-powered blogs."
Courtesy warrants me to thank the blogger team for selecting and showcasing this blog as one of blogger's "awesome" noteworthy blogs. This "recognition" by the blogger team is testament to the fact that human rights, fundamental freedoms and the rule of law are principles worth promoting. Blogs of Note has driven unprecedented traffic to this blog since it was listed, thereby amplifying the voice of the oppressed and the call for mutual respect of rights and freedoms around the world.
Courtesy warrants me to give a shout out to Steve from Common Cents whose comment on Somalian imprisoned for attacking cartoonist in Denmark called my attention to the fact that this blog has gone down into the archives of blogger's Blogs of Note.
On The Road To Success was listed as a noteworthy blog on Monday, February 07, 2011.
Well, enjoy getting about ten comments that go something like "I read your blog, congrats, now read my blog(INSERT URL HERE)" but yeah, congrats. not my cup of tea, but it seems like your doing good work.
Your blog is the BEST!!!! Is fantastique!!!! I´m following your blog!!!!
Congratulations on your recognition! I'm glad Blogger brought your blog to my attention. I'm currently pursuing my Master's in International Peacebuilding and have spent some time in West Africa studying human rights issues, in particular, child trafficking. I look forward to reading more from you!
Congratulations! Love seeing someone honored for a good job. Haven't seen your blog before so I'll check in from time to time.
I came across your blog via 'Blogs of Note'. I am thankful to the Blog of Note tab on my dashboard; without it I would have never found you. I appreciate your emphasis on human rights and wondered if I could share a domestic violence story with you (Fists and Blood http://normaltoeatpb.blogspot.com). Domestic violence is one of the worst kinds of violation of human rights because it's from someone you love.
congrats...keep up the amazing work!!!
@RS et al. Thanks for showing some love. I appreciate you all. Let's make the blog interactive. | 2019-04-26T04:16:04 | http://www.zuzeeko.com/2011/02/blog-of-note.html |
Perennials forum: What are you ordering for Spring??
I am most excited about the bulbs I ordered from 'Onalee's Seeds'. I have ordered seeds from her before but I did a Google search for a vine I wanted for spring and she had the best price on tubers. These may be a little invasive in the south but I am doing a container. Also I hear they are short lived. Who cares! They are beautiful.
'Gloriosa Lily', 4 tubers for only $12.00 and free shipping!
That's going to be beautiful. Post your pictures when it blooms!!
So far I have more daylillies around 20 coming and also ordered some Cheyenne Spirit coneflowers. Oh yes one more asiatic lily 3 bulbs and one OT 2 bulbs lily love them from the Lily Garden. Placed a order with Romence Gardens for half a dozen Little Trudy nepeta plants. Your lily is lovely my mother tried them one year but they didn't like our cool climate.
If you want to be happy for a lifetime plant a garden!
Faith is the postage stamp on our prayers!
Thanks! This is the second vine I ordered, the first was 'Major Wheeler', from niche gardens. My first order ever from them. Also got a 'Red Sprite' winter-berry, uses same pollinator that I already have called 'Jim Dandy'. So this is my fourth winter-berry!. I got the others from Bluestone Perennials last year.
It's all there, so far. I add to it when every so often.
That is quite a list and adding to it will just get you into more trouble!
I am still trying to figure out how to explain the 200 daylilies that are coming, gulp!
I got an email from Floyd Cove yesterday and they completed the order by asking me for my cvc code on back of card. They ask for that separately, not when you put your credit card number in. They shipped yesterday!!
Susan: your pix of the Gloriosa lily reminded me its another plant I have been promising myself.
Just added tomy Brent and Beckys order.
I got three emails from LA vendors that they have shipped my daylilies!! OMG, I have to go back to work tomorrow and back to eleven hour days. No end in sight and my vacation is a month away!! Yikes, no matter what I do it turned out this way but I think it is still better than getting 200 at one time. I taught my husband how to pot them up last year, I always seem to get overwhelmed for some reason. It is not like a do a lot of shopping!!
Brent and Beckys notified me the dahlia Urchen was not available and would I like a sub.
I agreed and when I saw the plant I liked it better.
Park Princess: its a shorter variety 28 inches.
Oh my!! how beautiful, you did good. I love dahlias! Especially the cactus variety.
I have not ordered that much so far , still need to see what overwintered. So far a couple Echinacea and Heuchera. I also ordered 8 or so Tiarella.
I said I was going to wait but I keep running into sales and finding stuff I've been wanting. My order from Bluestone was great. Two plants were 50% off then the rest were 10% off and then they give you a free plant if your order is over 75.00, and my order did end up that way.
Here is the whole order, one Hydrangea is for my girlfriend from work.
They had everything that was left on my wish list after ordering from Niche and GHS. I was thrilled to get the free plant and the discounts. Paul's Glory was not on my list but it does well here and I wanted a second one. This hosta takes the heat and doesn't bat an eye, even when you forget to water it!
I got plants from a coop last year but they died, they were not shipped till July. Everything here must get planted in May so it will put down roots before July otherwise it will not survive the heat.
I'm sorry to hear that. Don't do anymore co-ops that ship past May.
What plants did you get that died? | 2019-04-23T14:39:00 | https://garden.org/thread/view/16072/What-are-you-ordering-for-Spring/ |
The move also appears to be a tacit admission by the company that currently there is more of that opportunity in music subscriptions than there is in video.
The move also appears to be a tacit admission by YouTube that currently there is more of that opportunity in music subscriptions than there is in video, a landscape overrun with competition from deep-pocketed players including Netflix, Amazon, Hulu and Apple. While those companies are pumping several billion dollars each into premium programming and rich talent deals, sources say the budget for originals has not expanded meaningfully from the high nine-figures it spent last year despite the recent success of more high-profile projects like Cobra Kai. “The premium subscription service has been a tepid success at best,” notes GBH Insights analyst Daniel Ivesof early efforts to draw paying members through original programming alone. YouTube has not disclosed how many subscribers Red has.
A version of story first appeared in the May 23 issue of The Hollywood Reporter magazine. To receive the magazine, click here to subscribe. | 2019-04-19T08:50:58 | https://www.hollywoodreporter.com/news/youtube-bets-music-as-trojan-horse-boost-subscription-business-1114205 |
18×24 inches, Fine Art Giclee Print.
16×24 inches, Fine Art Giclee Print.
32 pages, Text by Joyce Chng. | 2019-04-23T06:12:01 | http://www.jeremypailler.com/shop/?lang=en |
Recently, four educators, selected to represent both GJ Academy locations, went to Redken’s Symposium 2015 in Las Vegas. The Symposium consists of three amazing days of Redken Education with the finest, most sought-after educators in the industry. Thousands of salon professionals participate every year.
What was your favorite part of the Redken Symposium?
Shawna: Favorite thing about Symposium was seeing international stylists using terms and techniques for styling hair that we teach the very first week of school.
Nicole: The classes were great, lots of new techniques and fun atmosphere.
Shea: It was great being around so many inspiring industry leaders! All of the classes I attended were packed full of new techniques to create beautiful interesting hair.
Myleyah: The Trend Report class!! It was fun, educational, and the head stylist let us take pictures with them at the end!
What was your favorite or funniest memory of the trip?
Shawna: Funniest thing that happened was when we had free time, which was very little, we did a bit of gambling and we would win a $1 and be shouting and cheering. People thought we were winning big because of our excitement. We had never really gambled before so the small wins were thrilling!
Nicole: Finding inexpensive places to eat.
Shea: Screaming for Shawna at the slot machines while she won all of her money!
What was it like to be one of four educators selected to attend the symposium?
Shawna: I was a little nervous at first but the closer it came to leaving the more excited I became. I feel honored to be one of the educators that get to deliver all the information we learned to my co workers so that they can share it with our students.
Nicole: Definitely an honor, it was a fun experience and to get to go with fellow educators was great.
Shea: It was so exciting to be able to be apart of the symposium. There was so many great classes that we got to attend and being in Vegas with 1,000 plus hair stylists was such a memorable inspiring experience!
Myleyah: It was an honor to be around people who were as passionate about the industry and education as much as we are.
Of all the things you learned, what was your biggest take away you can’t wait to share with your students?
Shawna: I loved seeing all the different stylists. There are so many things you can do with a cosmetology license whether being a stylist in a salon, owning a salon or being a famous hairstylist and seeing everyone in one place was so amazing!
Nicole: All of the great techniques, I have already showed them a few cutting and foiling techniques.
Shea: I’m excited to share with them the versatility that you can have with an airwave! The finished style is what allows the guest to leave with beautiful hair. By using the principles that we teach in the classrooms, taking your time, and using the right product you can create beautiful styles that can last a couple days! The Trainers at the event emphasized the point that it doesn’t matter how good the cut is if you can’t style the hair to look right.
Myleyah: The easiest way to create the most perfect bun ever!
What is your favorite Redken product & why?
Shawna: Velvet Gelatine 07 is my favorite Redken product. I love to run my fingers through my hair but need something that will hold my style. This product I put in my hair towel dried and it creates a little bit of bounce and natural shine with medium hold. Plus it has frizz and humidity protection which is much needed in our Seattle weather.
Nicole: I love Curvaceous since I have curly hair and because it smells great and gives my hair a lot of definition. A close second would be Wax Blast because you can use it for so many things.
Shea: My favorite Redken product is the Blonde Idol shampoo and Violet conditioner. The product is awesome because the shampoo is moisturizing, but will not weigh my fine hair down. I follow the shampoo with the violet conditioner and leave it in for 3 minutes, this helps keep my blonde hair looking fresh and bright! I am very excited to try a new product that we heard about at the symposium called extreme lengths. This product helps your hair grow 6″ in 1 year!
Myleyah: I loved the Metallic Mix 05. It is an up and coming trend that is temporary color that can be built to opaque coverage and comes in Silver and Gold. I even bought some and it’s so awesome!!!!
Thank you for sharing your experience with us ladies! Check out photos from their trip. | 2019-04-21T12:43:39 | https://genejuarezacademy.edu/2015/02/educators-go-to-redkens-symposium/ |
Hiding behind a modest name, (it translates as “Not Only Pizza”), down an unassuming alleyway, NSP is a grand, well-appointed space, recently refurbished. This is not a little neighbourhood Italian restaurant but a place with style and gravitas. Nevertheless the fare one would expect in any family trattoria is available. We tried an earthy valpolicella (Allegri Valpolicella 05) while the Vin Alto rosé had my partner in raptures – a real taste of Italia – from Clevedon! The wine list had a wide range of Italian and Kiwi wines.
The highlight of the evening was the contorni (appetizers) – we tried marinated ceviche-style fish, mixed fungi, and stuffed artichoke hearts (3 dishes for 19.50) – and even if what was in the filling of the artichokes eluded both us and the waiting staff, it was nevertheless divine. The other two contorni were barely less noteworthy, and even the pizza bread was dripping in flavoursome olive oil.
NSP may serve more than pizza but it is clearly what they do best. The menu listed both traditional and novo pizzas and I went for the former. The Capricciosa (22.5) was superb – a thin crust was not meagrely topped. My partner tried the pasta – the fusilloni with prawns (25.50) was nice if unremarkable. She soon had ‘food envy’ as I inhaled the pizza.
I couldn’t go past the fig, almond and berry strudel (13.50) for “dolci” which was enhanced by amaretto ice cream.
If there are criticisms to level at this pleasant evening they would be the brassy acoustics that made the table seem ever wider as the room filled, and the number of different faces that attended our table. One of the faces however was the manager who was attentive and likeable in the extreme.
NSP has been in Parnell for 12 years. For reasonable prices it provides an Italian dining experience with grandeur and not a gingham tablecloth in sight. | 2019-04-25T18:48:52 | http://www.viewauckland.co.nz/restaurants/non-solo-pizza-review-57632.html |
The Society for Neuroscience is committed to advancing the understanding of the brain and the nervous system by creating venues where great science gets shared, providing professional development for neuroscience professionals, promoting public education and general education in neuroscience research, and informing legislators and other policymakers about new developments.
The most cited peer-reviewed publication in the field, the journal celebrated its 30th anniversary in 2011 and remains a high-impact publication for new findings. It publishes 50 weeks a year and annually produces more than 17,500 editorial pages of emerging science.
Among the world's largest scientific meetings and one of the top five U.S. medical and health meetings, the SfN annual meeting draws more than 30,000 attendees for scientific presentations, poster sessions, professional workshops, and training programs. More than 500 exhibitors convene annually to create the largest neuroscience marketplace in the world.
An open-access journal from the Society for Neuroscience, eNeuro publishes high-quality, broad-based, peer-reviewed research focused solely on the field of neuroscience. eNeuro embodies an emerging scientific vision that offers a new experience for authors and readers, all in support of the Society's mission to advance understanding of the brain and nervous system.
SfN careers and training resources serve members worldwide at all stages of their professional lives. They are expanding to provide information about a diversity of career paths and increase online availability. The NeuroJobs Career Center is a major field resource, while programming for women and underrepresented minority scientists is crucial in fostering field's continued diversity. SfN also continues to focus on the professional development of early-career scientists.
SfN's mission emphasizes the importance of engaging and inspiring the public - young and old alike - about the progress and promise of brain research. BrainFacts.org, a public information initiative of The Kavli Foundation, the Gatsby Charitable Foundation, and SfN, provides authoritative and engaging information for the public, educators, and policymakers. Programs such as Brain Awareness help members engage year-round with the public in communities around the globe.
SfN advocates strongly for investment in basic science research and the responsible use of animals in research. In the United States, programs bring members to Washington, D.C., for advocacy days and engage them in local activities year round. Globally, SfN partners with many other international and national scientific societies to promote advocacy at the national level. | 2019-04-19T08:27:03 | http://www.sfn.org/about/what-we-do |
SPIRIT OF ROME has proven some promise over hurdles with a second at Fontwell and third at Hereford on his two spins over timber.
She dealt with the gentle floor nicely every time and there must be extra to return. Sin Sin appears to be getting the hold of issues and wasn’t crushed far at Ludlow final time.
She might be the largest hazard.
SAM’S GUNNER got here again from a yr off to go down by a size right here final outing. That was three weeks in the past so hopefully he gained’t present too many results from that run.
He noticed out this journey nicely and a repeat can be ok.
WHERE’S TIGER was getting back from an extended break when third at Newcastle on his chasing debut final day trip. He has been given slightly assist by the handicapper and ought to enhance.
Oak Classic didn’t take pleasure in himself at Sedgefield newest however was second right here earlier and can get on the podium.
PLANET NINE goes the proper method and ought to respect this step up in distance after an in depth-up third right here final day trip.
He went via the smooth floor nicely and comes from an in-type yard. Kansas Metropolis Chief received the job accomplished properly at Donny final time and a 7lb penalty will not be sufficient to cease him.
SAME CIRCUS discovered Listed firm somewhat scorching at Doncaster final time and drops again to a extra appropriate class right here.
She was an in depth third at Wetherby off this mark at Christmas and the cheekpieces are on for the first time, which can wake him up somewhat.
Timon’s Tara went down in an in depth end at Uttoxeter newest and ought to be aggressive once more.
ISKABEG LANE has been in cracking type at Market Rasen with a win and two thirds from his previous three runs.
He’s off the similar mark as these positioned runs and should not have any difficulty with this step up in distance.
Mount Oliver had a lot in hand when scoring at Fontwell newest and has possibilities underneath a penalty.
DERRYNANE gained with lots in hand right here over 2m final time and this longer distance shouldn’t be an issue. He was getting back from 5 months off so is more likely to be fitter.
Ought to he slip up Perseid is a constant performer at this degree and seems to be on a good mark. | 2019-04-19T01:08:53 | https://www.dizisports.com/horse-racing-ideas-chepstow-catterick-lingfield-and-wolverhampton-steve-mullens-betting-preview-for-the-racing-this-friday-february-2 |
1. Over-pounding: A 29-year-old man was diagnosed with something called Fournier’s gangrene. It is a rare type of microbial infection. He got this by mastur_bating so frequently that he’d opened up abrasions on the shaft of his pe_nis, which left him vulnerable to infection.
2. Squeezing too hard: Did you know that most incidents involving broken pen_ises happen during mastur_bation? Some guys can squeeze too hard and stroke down at the wrong angle, causing a rupture of their rod’s corpus cavernosa—the cylindrical tubes that fill with blood when you have an erec_tion. Swelling and leaking, as well as a dozen other complications, can cause permanent loss of function.
3. Doing it in motion: Multiple men have broken their peni_ses while mastu_rbating in moving cars. The vehicle stopped suddenly, causing a collision between the pen_is and steering wheel or dashboard. Bad idea.
4. Sticking things in there: For added stimulation, two different men decided independently that feeding stiff electrical wire into their peni_ses while mastu_rbating was a good idea. One of the guys pushed the wire so far down his shaft that it coiled in his bladder. In both cases, doctors had to perform surgery to remove the wire. | 2019-04-23T02:57:29 | https://www.celebgossip.co.za/international-news/475-when-m-sturbating-never-make-these-4-mistakes.html |
Control Room: A film about the differences between American and Arab journalism before and during the war in Iraq. Absolutely riveting. Watching journalists from Al Jazeera and the US networks sitting across from each other and commenting on (then current) events both puts things into and takes things out of perspective. One of the best examples is the reporting by Al Jazeera of the toppling of Sadaam’s statue in Baghdad. Instead of the cheering “crowd” we were shown, it looks more like a half-dozen teenagers following a script. I’ll never see the news in the same way again. | 2019-04-20T10:17:02 | https://www.baty.net/2004/review-control-room/ |
Note: You currently don't need this update unless you are using the 64-bit version of Logic 9.1.2 or later.
This update is required to be able to use REX files in the 64-bit version of Logic 9.1.2 or later. Please note that the 64-bit version no longer supports Power PC. After downloading, please run the "Install Rex library" installer. This replaces the REX Shared Library with the latest version. | 2019-04-22T08:24:22 | https://help.propellerheads.com/hc/en-us/articles/360002216393-REX-Shared-Library |
Serbian ice hockey national team game worn jersey used by forward Nenad Rakovic in 2011 Division 2 World Championships in Melbourne, Australia. Rakovic played all 4 games in the tournament and Serbia used red jerseys in three of them, against New Zealand (W 6-4), Mexico (W 7-0), and Australia (L 2-4). All teams played exceptionally only 4 games because North Korea didn't arrive to Australia appealing to lack of funds. Serbia was relegated from Division 1 in 2010 after promoting there 2009 and were hoping to return there again.
Serbia lost their first game to Belgium 2-3 despite outshooting Belgium 38-22. After winning next two games, the promotion was at Serbians own hands. They had to win unbeated Australia on regulation to win the tournament. Rakovic scored the game's first goal on a power play but Australia tied the game only 9 seconds later. Serbia once again outshot their opponent clearly, 44-21, but Australian netminder Matthew Ezzy was in great shape and helped his team to Division 1 B for 2012. Meanwhile Serbian goalie Milan Lukovic was having one of the worst games of his career. He was pulled before the middle of 2nd period when Australia took 3-1 lead. By that he had only 4 saves on 7 shots while Ezzy had probably over 20 saves.
Since 2007 Rakovic have represented Serbia in all except two World Championship tournaments (2009, 2010). He have also played for Serbia-Montenegro and Yugoslavia national teams.
The jersey has some puck marks on the shoulders and sleeves. The nameplate is sewn with individual letters heat pressed onto it. All other graphics and numbers are sublimated. The jersey was obtained from a private collector in Canada. | 2019-04-19T04:16:28 | https://gamewornjerseys.weebly.com/serbia.html |
ToToTEK.COM :: View topic - Game Doctor SF7 advice.
I see what you mean. Portable emulation has always been a bother to me. The NDS emulation support is possibly the worst I'll just stick to PC with ZSNES.
The Sega CD cord, I've never made anything like that before. It seems easy but I don't know. Do you recommend it for a beginner? I took two Electronics courses in DC circuitry at a trade school a few years ago. I made some boards and stuff but I've forgotten a lot of it. I do remember how to solder though.
The GB/GBC dumper is so much money. They are $120-150 dollars from what I've found. There has to be a cheaper solution. Maybe making my own is an option, I don't know yet I'll think about it.
There is the Sega CD Transfer Cable. Out of stock at the moment it appears. You may try emailing or messaging Tomy if there will be more stock soon.
You could try getting a SNES Copier with the Super Smart Card Gameboy adapter as well. I'm sure there are other devices out there and probably some homemade cartridge reader projects but I don't have any experience with them.
I did see that, he posted a guide on how to make it basically. Do you think it would be an easy project?
I can't say, that depends on your skill level. It could be difficult if you aren't used to that sort of thing or if you are it could be extremely easy.
Do I just need a sega controller connector, with a wire and a Parallel connector and open it up, and map the wires of the sega controller to the corresponding pins on the parallel connector? And solder the wires to those connections? That seems easy enough.
I don't have the instructions. If its straight wire to wire that's easy. If you feel comfortable doing it, try it out. I think I tried once but it didn't work. Though now I suspect it wasn't my cable but probably the parallel port's operation mode.
Ah I see. I'll give it a try when I buy a Sega CD. That will be a long time down the road.
Should I need to wait till late September when the Retrode goes up for sale? | 2019-04-19T03:26:14 | http://tototek.com/phpBB2/viewtopic.php?p=21830& |
The Musical “Fela and The Kalakuta Queens” is a demonstration of the rich cultural heritage that Nigeria is blessed with. The play, which tells the story of the legendary musical icon and activist Fela Anikulapo Kuti, reveals the sensational life of the Queens of Kalakuta and unmasks common misconceptions about them.
After an impressive show earlier in the year at the Ultra-modern Terra Kulture, the play sponsored by information and telecommunication company, MTN, made its debut at the esteemed Africa Shrine on Sunday, October 14, 2018.
The ICT company in the last few years has supported causes that seek to promote the Nigerian cultural heritage. A recent example is the just concluded African Drum Festival in Ogun state which is geared towards promoting cultural orientation among Nigerians and also support talent and creativity.
The story of Fela and his Kalakuta Queens is a compelling musical about the honest and selfless love the icon had with his dancers(Queens) who left their homes to follow him, believing in his vision of building a better community through arts and music; an attribute we all need to imbibe in the Nigeria of today. | 2019-04-26T15:56:43 | http://thenet.ng/mtn-takes-fela-kalakuta-queens-train-new-afrikan-shrine/ |
Sir Harold Evans helmed a panel to discuss the merits of free and uncensored art. The sold out event was put together by Glenn D. Lowry and Klaus Biesenbach of Moma and Anne Pasternak of Creative Time in little more than a week. There is apparently a great hunger to discuss and try to understand the values of free expression in our increasingly dangerous world. The panelists included artists Sharon Hayes, Kadar Attia, comedian Aasif Mandviwala, Jason Mojica, Editor-in-Chief of Vice News, and Art History Professor Simon Schama. It was organized with the help of Creative Time.
Aasif: has more to do with coming up with a newsworthy act for al qaeda .
Simon: Art’s not the issue; we have to fight the gains of the Enlightenment all over again.
Jason: Vice didn’t publish Hebdo’s cartoon of Mohammed after the shooting because it wasn’t news.
Kader: Injury of colonization in France is deep; radical Islamism — there are legitimate reasons they are inspired.
It wasn’t the most coherent discussion but it was lively and important. We need to talk about these things…like why we’re still supporting a relationship with fundamentalist Saudi Arabia while bloggers get a thousand lashes and women fight for the right to drive.
Piss Christ’s Andres Serrano sat behind me; one artist who has had to deal with objections to his transgressive and beautiful work. | 2019-04-23T12:17:17 | https://notjustaboutsex.com/2015/02/ |
i like this last option the most, but i’ve been using the link to iNaturalist in the footer at the bottom of the iNatForum pages for now.
unfortunately, it is obscured if you have the text input pane up.
I never noticed this before. Thanks!
how strange! that seems to defy logical UI development practices. i guess there’s a bias against those who have chosen the dark side.
Maybe just a bug in our implementation, we can investigate next week.
After a bit of use it would also be cool if not only was there a prominent link back to iNat in the header, but links from forum profiles to iNat profiles. As I’m interacting with other members in this new way the discussions sometimes leave me feeling “this person seems pretty cool, I’d like to go see what they’ve observed.” So I absentmindedly click on their username and get their forum profile, which does not achieve that purpose. Then I realize my mistake and navigate to iNaturalist and then run a search on their username to find them on iNat. Would links from forum profiles to iNat profiles be possible? It just makes sense to me, as our activity on both sites is fundamentally linked.
theoretically, you could use a different account name in iNatForum than you do over at iNaturalist. i guess you could even claim a name on iNatForum that someone else uses at iNaturalist. probably no one would do that though, right? | 2019-04-22T23:59:06 | https://forum.inaturalist.org/t/link-back-to-inaturalist-org-from-forum/1404 |
I'm here really quick to share last week's SCS challenge card. I know that a new one is posted for today; and originally I was going to try to do both and post them; but I just didn't get time. To be honest, I'm out of stamping mojo for the day....too much Christmas spirit and doings, which is a good thing!
I couldn't get the card to stay still on the scanner, so that's why it appears a bit crooked at the top and bottom. Lots of layers on this card. I started with Not Quite Navy and then added the Ruby Red layer. The ran the two Going Grey pieces through my CB with an embossing folder before I mounted them onto the Taken with Teal pieces. I added the strip of Not Quite Navy across the middle with the square pewter brads. I used SU's "Circle Circus" for the main image in the middle; and the sentiment is from SU's "Lots of Thought" set. I used 2 layers of dimensionals on the back of the circles piece, which gives it quite a bit of a 3D affect.
Anyhow, that's all for me this week. Enjoy your Christmas Eve celebrations tomorrow and have a Merry Christmas on Friday!
Great card, love the colors.
what a fun card! I like all the circle stamps!!! Merry Christmas! | 2019-04-18T11:07:33 | http://www.perfectlycreatedchaos.com/2009/12/hi-everyone-im-here-really-quick-to.html |
In this article from The Times Herald, Chris Miller, district manager of Davey's King of Prussia office, urges property owners to consider hiring a professional to asses their trees' health status.
Tuesday’s storm may have misfired, but winter is far from over and our noble trees stand vulnerable to all kinds of damage yet.
Expert arborist Chris Miller is still tending to sick trees who took a blow from last February’s ice storm.
Miller noted that dormant issues include dead wood, cracks, weak branch joints, root problems and decay, which can all mean no dogwood blooms come springtime .
His advice to all property owners: look up — and consider hiring a professional to assess a tree’s health status.
Going the DIY route can be asking for trouble, he allowed. | 2019-04-25T01:54:46 | http://www.davey.com/about/newsroom/davey-in-the-news/upper-merion-arborist-trees-damaged-during-winter-storms-require-professional-care/ |
The aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to improve therapeutic ratios for therapeutic payload delivery.
Four hu3S193 variants (I253A, H310A, H435A and I253A/H310A) were generated via site-directed mutagenesis and radiolabelled with diagnostic isotopes iodine-125 or indium-111. Biodistribution studies in Lewis-Y-positive tumour-bearing mice were used to calculate the dose in tumours and organs for therapeutic isotopes (iodine-131, yttrium-90 and lutetium-177).
111In-labelled I253A and H435A showed similar slow kinetics (t 1/2β, 63.2 and 62.2 h, respectively) and a maximum tumour uptake of 33.11 ± 4.05 and 33.69 ± 3.77 percentage injected dose per gramme (%ID/g), respectively. 111In-labelled I253A/H310A cleared fastest (t 1/2β, 9.1 h) with the lowest maximum tumour uptake (23.72 ± 0.85 %ID/g). The highest increase in tumour-to-blood area under the curve (AUC) ratio was observed with the metal-labelled mutants (90Y and 177Lu). 177Lu-CHX-A" DTPA-hu3S193 I253A/H310A (6:1) showed the highest tumour-to-blood AUC ratio compared to wild type (3:1) and other variants and doubling of calculated dose to tumour based on red marrow dose constraints.
These results suggest that hu3S193 Fc can be engineered with improved therapeutic ratios for 90Y- and 177Lu-based therapy, with the best candidate being hu3S193 I253A/H310A for 177Lu-based therapy.
The use of monoclonal antibodies (mAbs) to deliver radioisotopes to tumour sites (radioimmunotherapy (RIT)) has been very successful in the treatment of haematologic tumours as the targeted radiation is able to kill the highly radiosensitive leukemias and lymphomas. Treatment of solid tumours that are generally more radioresistant has been less successful due to several factors including long serum persistence, poor tumour penetration and slow diffusion rates of mAbs . The large molecular size of mAbs (150 kDa) does not allow renal excretion. In addition, the Fc fragment of IgG antibodies interacts with the neonatal Fc receptor (FcRn, Brambell receptor), preventing it from being degraded in the lysosomes [2–6]. The resulting long serum persistence of large-sized mAbs cause dose-limiting radiotoxicity to normal tissues, principally red marrow.
The choice of the optimal radionuclide for RIT depends on its intended use. Physical properties such as path length, emission energy and physical half-life must correlate with a particular tumour size. 131I (E max, 0.66 MeV), suitable for tumours <1 cm, and 90Y (E max, 2.3 MeV), suitable for tumours >1 cm, are both β-particle-emitting isotopes and have been used in >95 % of clinical RIT trials . Similar to 131I, 177Lu (E max, 0.5 MeV) has been identified as having favourable characteristics for treatment of tumours particularly with heterogeneous antigen expression . Whilst 90Y and 177Lu labels are retained intracellularly after endocytosis, the 131I label is rapidly released from the cells [8, 9].
Early engineering approaches to reduce the serum half-life of antibodies and improve therapeutic ratios were based on reduction in antibody size by deletion of constant domains [1, 10, 11]. Our laboratory has previously evaluated smaller forms such as diabody, F(ab′)2 and tetrameric scFv constructs without an Fc fragment. These constructs showed a rapid elimination phase compared to wild-type IgG1, more rapid tumour targeting with the maximum tumour uptake observed at an earlier time point but strongly reduced maximal tumour uptake [12–14]. Another approach studied in preclinical studies to improve therapeutic ratio is pretargeted RIT. The multistep targeting approach allows the antibody to clear first before administrating the therapeutic radionuclide, and this approach has shown high increases in therapeutic ratio [1, 15].
The FcRn receptor recycles IgG antibodies into the blood circulation. During the last decade, the Fc-FcRn binding site has been well characterised, with I253, H310 in the CH2 domain and H435 in the CH3 domain identified as the key residues involved in the Fc-FcRn binding [16–19]. The FcRn-mediated IgG recycling can be described as a three-step process: (1) passive pinocytosis of IgG into endothelial cells; (2) in the acidic environment of endosomes (pH <6.5), histidine residues in the Fc fragment of IgG become protonated and this allows high-affinity binding of IgG to FcRn; and (3) unbound IgG will undergo lysosomal degradation whilst FcRn-bound IgG is released back into the blood circulation . Therefore, more recent engineering approaches to reduce the serum half-life of antibodies or Fc-coupled biological compounds used for payload delivery focus on mutating the specific amino acids in the CH2 or CH3 domain of the Fc fragment involved in the binding site of FcRn. Recycling of the variants is reduced, due to their diminished interaction with the FcRn receptor at pH <6.5. Most work has been done with radiolabelled Fc-containing antibody fragments such as scFv-Fc [20–23] and a minibody . Only one intact radiolabelled antibody (chTNT-3) carrying the I253A mutation has been studied in biodistribution studies and imaging studies .
We recently produced anti-Lewis-Y (Ley) humanised IgG1 variants carrying specific mutations in the Fc-FcRn binding region and investigated their binding properties to murine FcRn (muFcRn) and human FcRn (huFcRn) in vitro and in vivo . A good correlation was found with low in vitro binding to FcRn corresponding to fast blood clearance rates. Differences in blood clearance rates were observed between the murine and human FcRn mouse model, showing that one alanine mutation in the Fc-huFcRn binding site (i.e. I253A, H310A or H435A) was sufficient to completely abrogate binding to huFcRn and generate hu3S193 antibodies with clearance rates as fast as hu3S193 antibody fragments (e.g. (Fab′)2) without an Fc fragment. In contrast, two alanine mutations in hu3S193 Fc (e.g. I253A/H310A) were necessary to completely abrogate binding to muFcRn. Single non-alanine variants of hu3S193 that were able to completely abrogate muFcRn binding were I253D, I253P, H310D and H310E .
This study explored the impact of amino acid substitutions on conserved residues of hu3S193 that have been shown to be critical for maintaining serum persistence of human IgG1 antibodies as a means to improve therapeutic ratios for RIT in solid tumours using intact antibodies. Hu3S193 has been shown to have significant anti-tumour effect in animal models for delivery of radioisotopes, including 131I, 90Y and 177Lu [26–29]. A first-in-man phase I trial of hu3S193 in patients with Ley expressing tumours clearly showed the potential for delivery of radioisotopes using hu3S193 for selective targeting of solid tumours . The utility of hu3S193 mutants in cancer diagnosis and therapy were evaluated by pharmacokinetic, biodistribution, dosimetry and immunoscintigraphy studies in tumour-bearing mice.
The construction and production of hu3S193 and huA33 has been described before [31, 32]. The hu3S193 heavy chain (HC) was ligated into the pEE6.4 mammalian expression vector (Lonza Biologics, Slough, UK) via a HindIII and EcoRI double digest (pEE6.4/hu3S193 HC). pEE6.4/hu3S193 HC was used as a template for site-directed mutagenesis (GeneTailor™ Site-Directed Mutagenesis System (Invitrogen) or QuickChange II XL Site-Directed Mutagenesis Kit (Stratagene) to introduce the following substitutions in the CH2 and CH3 domains: I253A, H310A, H435A and I253A/H310A . The hu3S193 kappa light chain was ligated into the pEE14.4 mammalian expression vector containing the glutamine synthetase gene (Lonza Biologics) via a HindIII and EcoRI double digest. For the simultaneous expression of each mutated hu3S193 antibody, light and mutated heavy chain genes were cloned into a double-gene vector (pDGV) using a NotI and PvuI double digest. Freestyle 293-F cells (1 × 106 cells/mL) were transfected with the pDGV constructs according to the manufacturer’s instructions (Invitrogen). Supernatants were harvested at 96 h post transfection. Hu3S193 antibodies were purified using HiTrap KappaSelect columns (GE Healthcare). Purified proteins were analysed by SDS-PAGE under non-reducing conditions and evaluated by size exclusion chromatography on a Superdex 200 HR 10/30 column (GE Healthcare) using 0.01 mol/L sodium phosphate and 0.15 mol/L NaCl (pH 7.2) as elution buffer.
The Lewis-Y binding activity of hu3S193 antibodies was determined by BIAcore analysis using a synthetic Lewis-Y tetrasaccharide coupled to BSA (Alberta Research Council, Edmonton, Alberta, Canada) on a CM5 chip using a BIAcore 2000 as described (BIAcore AB, Uppsala, Sweden) . Hu3S193 antibody samples were diluted in HBS buffer (10 mM HEPES, pH 7.4, 150 mM NaCl, 3.4 mM di-Na-EDTA and 0.005 % Tween 20). Aliquots (60 μL) were injected over the sensor chip surface at a flow rate of 30 μL/min. After the injection phase, dissociation was monitored by flowing HBS over the chip surface for 300 s. Bound antibody was eluted, and the chip surface was regenerated between samples by injection of 100 mM HCl. For kinetic analysis, varying concentrations of hu3S193 wild type and mutants were injected (10, 19, 38, 75 and 150 nmol/L). Global analysis using a 1:1 Langmuir model fit was performed using BIA-evaluation version 4.1.1 software.
Fluorescence-activated cell sorter (FACS) analysis was done on Lewis-Y-positive A431 skin cancer cells. Aliquots of 2 × 105 cells were incubated with hu3S193 antibodies (200 nmol/L) in DMEM/F12 medium containing 10 % foetal bovine serum on ice. After washing the cells with PBS, cells were incubated with a goat phycoerythrin-conjugated anti-human IgG (Sigma) and incubated on ice for 30 min. Cells were washed with phosphate-buffered saline and resuspended in a final volume of 300 μL. In control samples, primary antibody was omitted. Flow cytometric analysis was done using a Guava EasyCyte Plus flow cytometer. Cancer cell populations were gated based on forward and side scatter variables. Data analysis was done using WinMDI (Joseph Trotter).
Hu3S193 antibodies were radiolabelled with four isotopes: 125I, 131I, 111In and 177Lu. Iodine-125 and lutetium-177 were obtained from PerkinElmer (PerkinElmer Life and Analytical Sciences, Waltham, MA), iodine-131 was obtained from ANSTO (ANSTO, Menai, Australia) and indium-111 was obtained from MDS Nordion (Canada).
Radioiodination was performed using pH-neutralised isotopes, catalysed by iodogen-coated glass beads as previously published [12, 33]. After a 10-min incubation period, the reaction mixture was purified through a Sephadex G50 desalting column (Sigma-Aldrich, Sydney, Australia) equilibrated with 0.9 % NaCl containing 0.05 % human serum albumin.
Radiolabelling of the hu3S193 antibody constructs with indium-111 and lutetium-177 was done by using the bifunctional metal ion chelate C-functionalized trans-cyclohexyl diethylenetriaminepentaacetic acid (CHX-A″ DTPA) [34, 35]. A chelate to antibody ratio of 3:1 was employed, using 0.1 M sodium bicarbonate buffer (pH 8.6) containing 0.9 % NaCl. Incubation was allowed for 16 h at room temperature. Under these conditions, one to two chelates are expected per antibody molecule. The radiolabelled mixture was purified through a Sephadex G50 desalting column equilibrated with 0.9 % NaCl containing 0.05 % human serum albumin.
Radiolabelling was performed on the day of injection into mice. Prior to injection, the percentage of unbound radionuclide content was determined by ITLC as previously described . Determination of the immunoreactivity of radiolabelled hu3S193 antibody constructs was performed by a single-point binding assay, where 10 × 106 Ley-positive A431 cells were incubated with 20 ng of radiolabelled antibody constructs for 45 min at room temperature with continuous mixing throughout to keep the cells in suspension. Cells were washed three times, and pellets were measured in a gamma counter (Cobra II, Model 5002, Packard Instruments, Canberra, Australia). Three samples of radiolabelled antibody at the same concentration as that initially added to the cells were measured at the same time of the cell pellets, and immunoreactivity was calculated: (cpm cell pellet/mean cpm radioactive antibody standards) × 100. Serum stability was analysed by determination of immunoreactivity on the day of injection, at 48 h, and 7 days after 20 ng of radiolabelled antibody was incubated in human serum at 37 °C.
Female athymic mice (BALB/c nu/nu; 4–6 weeks; Animal Resources Centre) were injected in the tail vein with 0.185 MBq 125I-mutant (2.5–5 μg, 5 μCi) and 0.185 MBq 131I-hu3S193 (2.5–5 μg, 5 μCi) wild type antibody (n = 5). A separate group of athymic mice were injected with 0.185 MBq 125I- hu3S193 mutant (2.5–5 μg, 5 μCi) and 0.185 MBq 111In-hu3S193 (2.5–5 μg, 5 μCi) mutant (n = 5). All animal studies were approved by the Austin Hospital Animal Ethics Committee and were conducted in compliance with NHMRC Australian code of practice for the care and use of animals for scientific purposes. Blood samples (10–20 μL) were collected from groups of five at 5 min, 1, 2, 4, 8, 24, 48, 72, 120, 168, 240 and 336 h after injection of radioactive antibodies. Samples were counted in a gamma counter (Cobra II). Standards prepared from injected material were counted each time with blood samples enabling calculations to be corrected for physical decay of isotope.
Biodistribution studies were done with athymic non-tumour-bearing mice (BALB/c nu/nu, female, 4–6 weeks) or mice bearing A431 tumours (111In, 0.657 ± 0.216 g; 131I, 0.515 ± 0.195 g; 177Lu, 0.466 ± 0.086 g). To study the tumour uptake and biodistribution in normal tissues of radioiodinated hu3S193 variants, A431 tumour-bearing BALB/c nu/nu mice were co-injected intravenously with 0.185–0.74 MBq (5–20 μCi) 131I-hu3S193 variants (2–6 μg protein) and 0.185–0.74 MBq 125I-hu3S193 wild type (2–6 μg protein). In a second study, 0.185–0.74 MBq 111In-CHX-A″ DTPA-labelled mutant (2–6 μg protein) and 0.185-0.74 MBq 125I-labelled hu3S193 wild type (2–6 μg protein) were co-injected. 111In-CHX-A″ DTPA-labelled wild type and 125I-hu3S193 wild type were also injected as a control group. 125I-hu3S193 wild type was used as an internal control in all injected animals to enable direct comparison between the different mutants. Typically, groups of four to five mice were sacrificed at 4, 24, 48, 72, 120, 168, and 240 or 288 h after injection of radiolabelled antibodies. For evaluation of 177Lu-labelled antibodies, mice were sacrificed at 48 h after injection. At the designated time points, groups of mice (n = 4–5) were humanely sacrificed by over-inhalation of isoflurane. Mice were bled by cardiac puncture, and tumours and organs (skin, liver, spleen, small intestine, stomach, kidney, brain, bone (femur), lungs and heart) were immediately removed and blotted dry. All samples were weighed and counted in a dual gamma scintillation counter (Cobra II, Packard Instruments). Triplicate standards prepared from the injected material were counted at each time point with tissue and tumour samples enabling calculations to be corrected for the physical decay of the isotopes. Results of the radiolabelled antibody distribution over time were calculated as the mean percentage injected dose per gramme (%ID/g ± SD) for each mutant and parental hu3S193 per time point.
Antibody serum concentrations were expressed as percentage injected dose per millilitre (%ID/mL), and the blood concentrations (μg/mL) were calculated. A two-compartment IV bolus model with macro-parameters, no lag time and first order elimination (WinNonlin Model 8) was fitted to serum data obtained from blood clearance studies for each animal using unweighted non-linear, least squares with WinNonLin version 5.2 (Pharsight Corp., Mountain View, CA). Estimates were determined for the pharmacokinetic parameters: alpha half-life (t 1/2α), beta half-life (t 1/2β), area under the curve extrapolated to infinity (AUC0-∞) and mean residence time (MRT). Alpha half-lives of mutant hu3S193 were constrained to be smaller or equal to the alpha half-life of hu3S193 wild type. Significant differences in these values were examined by comparing the coefficient of variation (CV %) for the estimated parameters.
To estimate radioimmunotherapeutic applications for 90Y- or 177Lu-labelled mutants, biodistribution data obtained with 111In-CHX-A″ DTPA-labelled antibodies were used to generate time-activity curves for the calculations of predictive radiation doses for the bone marrow, liver, kidneys and tumour. Identical biodistribution and biologic clearance of 111In-, 90Y- and 177Lu-labelled antibodies were assumed. Predictive dosimetric analysis was also done for 131I-labelled antibodies based on biodistribution data obtained with 125I-labelled antibodies. As radiation absorbed doses are proportional to %ID/g, time-activity curves for the blood, liver, kidneys and tumour were integrated over time to calculate area under the curve (AUC). Time-activity curves generated from biodistribution data were corrected for radiodecay. Therefore, the pharmacokinetic values calculated from such data refer to pharmacological values of the antibodies in the absence of radioisotope. Appropriate physical half-life corrections were applied to convert %IDpharmacological/g to %IDradioisotope/g, and the time-activity curves were fit to either a two or three exponential function from which the AUC is determined for 90Y, 177Lu and 131I. AUC integration from zero to infinity was done by the sum of a trapezoidal integration of the measurement range (AUC0–288 h) plus an extrapolated model fit for the extrapolated range (AUC288 h–∞). To calculate accumulated activity, photon dose and edge effects were ignored. Dose to red marrow was determined from blood concentrations using a baseline value of 0.1 .
All the SPECT and MR scans were performed on a small animal nano-SPECT/CT imaging system and a small animal nano-PET/MR imaging system (Mediso nano-ScanPM, Mediso Medical Imaging Systems, Budapest, Hungary) individually. Groups of two mice were injected with 3.7 MBq (270 μg) 177Lu-CHX-A″ DTPA-labelled antibody (huA33 wild type, hu3S193 wild type or hu3S193 I253A/H310) and serially imaged at 2 days post injection. Imaging procedures involved anaesthesia of mice by isoflurane. Each mouse was scanned in supine position with its head secured via ear and tooth bars. Respiration was monitored by a pressure-sensitive pad adhered to the abdomen. The imaging study started with a whole body T1-weighted MR scan, followed by a 60-min SPECT scan which was reconstructed into a volumetric image with the voxel size of 0.3 mm × 0.3 mm × 0.3 mm using the Mediso Tera-TOMO® Monte Carlo-based algorithm. Subsequently, reconstructed SPECT and MR images were transferred to a research PACS system where the images could be retrieved for further processing and analysis.
To confirm data obtained from imaging, groups of five mice bearing A431 tumours were injected with 6.29 MBq (100 μg) 177Lu-CHX-A″ DTPA-labelled antibody (huA33 wild type, hu3S193 wild type or hu3S193 I253A/H310) and sacrificed at 48 h post injection. Organs and blood were collected as described before, and the radiolabelled antibody distribution over time was calculated as the mean %ID/g ± SD for each antibody per time point.
To compare tumour uptake at different time points for the mutants versus hu3S193 wild type, two-way ANOVA with the Bonferroni post test was performed using GraphPad Prism version 5.00 for Windows, GraphPad Software, San Diego California USA www.graphpad.com. Tumour-to-tissue ratios or tissue uptake at specific time points were analysed using one-way ANOVA with Tukey’s multiple comparison post test. When less than three groups were compared, a non-parametric t test (one-tailed) was used.
To investigate whether hu3S193 antibodies with reduced serum persistence would benefit payload delivery, three hu3S193 single variants (I253A, H310A, H435A) and one double variant (I253A/H310A) were generated. All antibodies were expressed in transiently transfected freestyle 293-F cells. Expression yields of antibodies ranged from 15 to 40 mg/L in shake flasks containing 60 mL medium. HiTrap KappaSelect columns were used to purify antibodies. Quality control using SDS-PAGE and HPLC on a Superdex 200 column showed highly pure antibody preparations with >98 % purity. All mutants maintained effective antigen binding in FACS analysis and BIAcore (Additional file 1: Table S1).
Antibodies were radiolabelled with iodine-125 and indium-111, and radiochemical purity of all injected antibodies was more than 98 %. Immunoreactivity was determined in the presence of human serum at 37 °C for up to 6 days of incubation, as measured by percentage of antibody binding to Lewis-Y-positive A431 cells in a single-point immunoreactivity assay. Data presented in Table 1 demonstrates minimal loss in binding of all variants compared to wild type at day 0 due to labelling (20–35 %). Loss of immunoreactivity due to incubation in human serum at 37 °C was similar for variants and wild type (day 7: 55–70 %).
Blood clearance studies were performed in BALB/c nu/nu mice (n = 5) using 125I-labelled antibody co-injected with their 111In-CHX-A″ DTPA-labelled counterpart, and blood clearance parameters were calculated (Table 2). There was no significant difference between the elimination half-lives (t 1/2β) of radioiodinated or radiometal-chelated hu3S193 wild type. Radioiodinated hu3S193 variants showed shorter half-lives than their radiometal counterpart; the shorter the half-life the smaller the differences in half-lives observed between radioiodinated and radiometal-chelated hu3S193 mutants. Although different terminal serum half-lives were seen dependent on the choice of isotope, a similar ranking order of area under the curve (AUC) was observed: wild type>H435A = I253A>H310A>I253A/H310A (Table 2).
In general, a significant reduction in tumour uptake was observed with faster clearing variants; the faster the blood clearance of the variant, the higher the reduction in tumour uptake (Fig. 1). Additional file 1: Table S2 shows the biodistribution results of 111In-CHX-A″ DTPA-labelled antibodies. Additional file 1: Table S3 shows the biodistribution results of 131I-labelled antibodies. Two-way ANOVA of differences in tumour uptake at different time points post injection of each variant compared to wild type is shown in Additional file 1 (111In-labelled variants versus 111In-labelled wild type, Additional file 1: Figure S1; 131I-labelled variants versus 125I-labelled wild type, Additional file 1: Figure S2). Radioiodinated hu3S193 antibodies cleared faster than their 111In-chelated counterparts, and as a result, lower tumour uptake was observed with radioiodinated variants compared to their 111In-chelated counterparts (Fig. 1, Additional file 1: Table S2 and Additional file 1: Table S3).
Although a significant reduction in tumour uptake was observed with faster clearing hu3S193 mutants, more favourable tumour-to-blood ratios were observed for 111In-labelled hu3S193 H310A and 111In-labelled hu3S193 I253A/H310A compared to wild type (Table 3). At 48 h post injection, 111In-labelled wild type showed a tumour-to-blood ratio of 2.70 ± 0.26 compared to 5.04 ± 2.04 for H310A (P < 0.05) and 32.81 ± 7.10 for I253A/H310A (P < 0.001). Tumour uptake was significantly lower for all 131I-labelled mutants compared to wild type (P < 0.0001) at all time points except 4 h post injection (Fig. 1, Table 3, Additional file 1: Table S3, Additional file 1: Figure S2). No significant differences in tumour uptake were observed between mutants. As seen with the 111In-labelled mutants at 48 h post injection, tumour-to-blood ratios for 131I-labelled mutants were more favourable than wild type (Table 3).
As expected for large proteins (>60 kDa), all hu3S193 variants exhibited a hepatic clearance. This is evidenced by the 111In-labelled variants showing an increase in liver uptake at early time points with increased blood clearance rates (Fig. 1f). Liver uptake for the slowest clearing mutants hu3S193 H435A and hu3S193 I253A peaked at 4 h p.i. (9.49 ± 0.76 %ID/g and 15.52 ± 3.45 %ID/g, respectively). The fastest mutant hu3S193 I253A/H310A reached a maximum liver uptake at 24 h p.i. (18.68 ± 1.34 %ID/g).
To calculate the therapeutic ratio for hu3S193 variants with faster blood clearance, AUC values were calculated for blood of labelled (131I-, 90Y-, 177Lu-) antibodies and tumour-to-blood AUC ratios were calculated (Table 4). With exception of the I253A variant, all mutants demonstrated higher or similar tumour-to-blood AUC ratios compared to hu3S193 wild type. The highest increase in tumour-to-blood AUC ratio was observed with the metal-labelled mutants with 177Lu-CHX-A″ DTPA-hu3S193 I253A/H310A showing a doubling in the tumour-to-blood AUC ratio compared to hu3S193 wild type and other variants. No increase in tumour-to-blood AUC ratios was observed with the faster clearing radioiodinated variants.
AUC ratios were also calculated for tumour-to-liver and tumour-to-kidney as these clearing organs could be dose limiting, especially for radiometal-labelled mutants. The lowest tumour-to-liver AUC ratios were observed with the 90Y-labelled (1) and 177Lu-labelled (1.9) hu3S193 I253A/H310A. Tumour-to-kidney ratios were lowest for 90Y-hu3S193 I253A (2.4) and 90Y-hu3S193 I253A/H310A (2.5) followed by 90Y-hu3S193 H310A (3.1) and 177Lu-hu3S193 H310A (3.1). Tumour-to-liver AUC ratios were superior for the 131I-labelled variants with the highest tumour-to-liver AUC ratio observed with 131I-hu3S193 I253A/H310A (5.6).
To predict which hu3S193 mutant would be the best candidate for radioimmunotherapy, dose-limiting toxicity for the bone marrow was set at 150 cGy . 90Y-CHX-A″ DTPA-hu3S193 H310A reached a tumour-absorbed dose 1.2-fold higher than hu3S193 wild type (H310A, 4050 cGy; wild type, 3300 cGy) (Fig. 2). 177Lu-CHX-A″ DTPA-hu3S193 I253A/H310A was predicted to be the best candidate for 177Lu-therapy, reaching a tumour dose of 8947 cGy compared to 4650 cGy for 177Lu-labelled wild type, limited by bone marrow toxicity (Fig. 2).
Qualitative imaging was performed with hu3S193 wild type, hu3S193 I253A/H310A and huA33 control in A431 tumour-bearing mice. Mice were injected with 3.7 MBq (100 μCi, 270 μg) of radiolabelled antibody. HuA33 wild type was used as a negative control as the A431 cell line does not express A33 antigen. Quality controls showed that at day 0, only 3.4 % of 177Lu-CHX-A″ DTPA-labelled huA33 bound to A431 cells in vitro. In contrast, 177Lu-CHX-A″ DTPA-labelled hu3S193 wild type and I253A/H310A demonstrated a good binding at day 0 (72.6 ± 4.3 % and 53.9 ± 3.9 %, respectively; n = 3, SD) gradually decreasing to 25.0 ± 2.5 % (wild type) versus 18.4 ± 1.4 % (I253A/H310A) after 6 days of incubation in human serum at 37 °C.
Whole body scans were obtained at 48 h post injection (Fig. 3). By 48 h, images showed tumour uptake for 177Lu-CHX-A″ DTPA-labelled hu3S193 wild type (Fig. 3a, d) and I253A/H310A (Fig. 3b, e). No tumour uptake was shown with the huA33 control demonstrating specific tumour uptake of hu3S193 wild type and I253A/H310A mutant in A431 tumours (Fig. 3c, 3f). High tumour uptake, high blood pool and background activity for hu3S193 wild type compared to hu3S193 I253A/H310A were observed. Volume of interest analysis for the heart, liver and tumour was used to calculate averaged uptake per pixel. Hu3S193 wild type had a lower tumour-to-heart ratio compared to I253A/H310A (wild type, 2.53 ± 0.07; I253A/H310A, 7.34 ± 2.05; n = 2). The tumour-to-liver ratio was higher for wild type (4.40 ± 1.51, n = 2) compared to I253A/H310A (1.35 ± 0.15; n = 2).
In a separate biodistribution study, mice were injected with 177Lu-CHX-A″ DTPA-labelled hu3S193 wild type or I253A/H310A (n = 5). After 48 h post injection, mice were sacrificed and organs were counted for radioactivity (Table 5). Biodistribution results confirmed reduced tumour activity of I253A/H310A (16.95 ± 3.60 %ID/g) compared to hu3S193 wild type (44.81 ± 3.35 %ID/g; P < 0.01). Tumour uptake of 177Lu-CHX-A″ DTPA-labelled I253A/H310A was specific and significantly higher than 177Lu-CHX-A″ DTPA-labelled huA33 (10.35 ± 0.54, P < 0.01). Importantly, tumour-to-blood ratios were 2.93 ± 0.65 (hu3S193 wild type), 0.49 ± 0.30 (huA33 control) and 16.56 ± 3.71 (hu3S193 I253A/H310A). Tumour-to-liver ratios were 7.71 ± 1.26 (hu3S193 wild type), 6.37 ± 0.62 (huA33 control) and 1.20 ± 0.23 (hu3S193 I253A/H310A).
Higher protein doses were used for imaging with 177Lu-CHX-A″ DTPA-labelled hu3S193 antibodies (270 μg) and biodistribution (100 μg). Tumour uptake with 5 μg (~0.25 mg/kg) 111In-CHX-A″ DTPA-labelled hu3S193 antibodies was not significantly different from tumour uptake with 100 μg (~5 mg/kg) 177Lu-CHX-A″ DTPA-labelled hu3S193 antibodies as shown in Additional file 1: Figure S3, suggesting that at least at the 5 mg/kg dose level, no blocking of receptor has occurred.
Fc engineering is a promising technique to increase the therapeutic ratio for payload delivery. This approach aims to increase the therapeutic efficacy by reducing the terminal half-life of antibodies or Fc-containing antibody constructs, thus reducing the dose-limiting toxicity to the blood and bone marrow of intact radiolabelled therapeutic antibodies. In this study, four variants of an intact IgG1 antibody, hu3S193, with a broad range in half-life were created by site-directed mutagenesis and analysed in blood clearance studies and biodistribution studies. Our results show that hu3S193 can be engineered with improved therapeutic ratios for 90Y- and 177Lu-based therapy, with the best candidate being hu3S193 I253A/H310A for 177Lu-based therapy, achieving almost double tumour-to-blood AUC ratios compared to wild-type hu3S193.
Four Fc variants of an intact IgG1 antibody, hu3S193, with a broad range in serum half-life were created by site-directed mutagenesis and analysed in preclinical blood clearance studies and biodistribution studies. Non-specific uptake of hu3S193 wild type in a Lewis-Y-negative cell line SW1222 is known to be low ; in addition, in this study, a non-specific IgG1 control antibody huA33 showed low uptake in A431 tumours at 72 h post injection. Therefore, the tumour uptake of radiolabelled hu3S193 mutants was specific and antigen-mediated.
Early engineering approaches using deletion of constant domains to reduce the serum half-life of antibodies have shown that tumour-to-normal dose ratios can be improved [1, 10, 11, 37]. More recently, studies by Kenanova et al. reported on therapy prospects of radioiodinated and radiometal-labelled Fc-engineered anti-carcinoembryonic antigen (CEA) scFv-Fc fragments [20, 21]. Dosimetry calculations predicted that the 131I-labelled scFv-Fc H310A/H435Q could deliver >7000 cGy, limited by red marrow toxicity. 90Y-labelled scFv-Fc I253A was best suited for 90Y delivery, although dose predictions did not match the intact cT84.66 antibody. The current study extends their findings to an intact IgG1 and includes predictions for 177Lu-based therapy. In contrast to the anti-CEA study by Kenanova et al., the radioiodinated anti-Ley hu3S193 variants cleared much faster than the radioiodinated scFv-Fc fragments, and therefore, no therapeutic benefit could be obtained from the radioiodinated hu3S193 variants. The hu3S193 variants might be more sensitive to deiodination in vivo compared to the scFv-Fc variants. To study the benefit for RIT of using radioiodinated hu3S193 variants with faster blood clearance, other radioiodination methods such as site-specific radioiodination of cysteine-containing hu3S193 variants could be explored .
Whilst a doubling in dose to the maximum predicted dose calculated for hu3S193 wild type was predicted and a doubling in the tumour-to-blood AUC ratios achieved, the dose needed for tumour eradication in patients is likely to be higher than that achievable with a single infusion. Ley-expressing tumours such as colon, lung, ovarian and breast cancer require radiation doses of at least 60 Gy to eradicate solid tumours in patients . Reducing the half-life of systemically administered antibodies is usually associated with reduced uptake in tumour; however, AUC ratios of tumour and blood address the varying effects of alterations in antibody kinetics, and our results confirm that selective IgG1 mutations do provide benefit in therapeutic ratios. Approaches to further increase therapeutic efficacy of Fc-engineered intact antibodies with reduced half-lives can include dose fractionation , use in pretargeting radioimmunotherapy approaches or combination with chemotherapy [28, 29]. To date, pretargeting approaches show advantages compared to improvements in one-step RIT for improved tumour-to-normal tissue AUC ratios and tumour responses in preclinical models of solid tumours , but challenges remain to develop non-immunogenic and translatable approaches for human trials.
Due to the toxicity limitations of RIT and patient tumour variability, it is useful to develop theranostics to guide dosimetry in patients, exemplified in this study by 177Lu-labelled I253A/H310A. The imaging results reflect the biodistribution data; the highest tumour uptake was seen with hu3S193 wild type, but specific tumour uptake was still achievable with the fastest clearing hu3S193 variant I253A/H310A, and tumour-to-blood ratios were far higher at earlier time points with the mutant hu3S193 constructs. However, because 177Lu can only be imaged using SPECT cameras, a PET equivalent such as 89Zr-labelled I253A/H310A might be a better alternative and may allow better quantification of tumour uptake and saturability in vivo. We are currently evaluating 89Zr-labelled hu3S193 variants in tumour-bearing mice in small animal PET studies.
A higher protein dose was used for 177Lu-imaging (270 μg) and biodistribution (100 μg) studies versus 111In-biodistribution (5 μg) studies. We demonstrated that tumour uptake at 5 and 100 μg protein doses were comparable. Lewis-Y expression is very high on A431 cells and similar to MCF-7 cells, estimated to express around 106–107 antibody binding sites . A recent report on ABT-806, a humanised antibody that specifically targets epidermal growth factor receptor (EGFR), reports on cold competition blocking of the 806 antibody in A431 tumours . EGFR is highly expressed in A431 cells, and therefore, more than 20 mg/kg of cold ABT-806 antibody was needed to allow competition in vivo. It is therefore expected that competition with hu3S193 antibodies will only occur at doses higher than 20 mg/kg, which aligns with the observation that at the 5 mg/kg dose (100 μg), no reduction in tumour uptake was observed at 48 h post injection.
Although significant increases in therapeutic doses were predicted with some variants compared to hu3S193 wild type, increased toxicities to normal tissue such as the liver and kidneys were also predicted. A shift in toxicity from the bone marrow to liver as toxicity limiting organ for radiometal-labelled antibody variants with a faster blood clearance is not surprising. As the antibody variants clear faster from the body, radioactivity exposure to the blood is reduced. In addition, due to the reduced binding affinity of the variants for FcRn, an increase in catabolism is expected as the variants are no longer recycled in the blood circulation and degraded in the lysosomes (e.g. hu3S193 I253A/H310A) . In contrast to radioiodine, the small radiometal-labelled metabolites are trapped in the lysosomes of hepatocytes , and thus, a higher initial uptake of radioactivity observed in the liver is the result of enhanced accumulation of radiometal chelates after degradation of the variants in the lysosomes of hepatocytes. However, a mouse model might not be readily translatable to human studies to estimate liver and kidney toxicities developing from catabolites due to differences in stability of radiolabelled conjugates in human serum and relative size of tissue compartments between mouse and human. A theranostic might therefore also aid in appropriate dose selection when using engineered intact antibodies with altered pharmacokinetics.
Four Fc variants of an intact IgG1 antibody, hu3S193, with a broad range in serum half-life were created by site-directed mutagenesis and analysed in preclinical blood clearance studies and biodistribution studies. We have shown that hu3S193 can be engineered with improved therapeutic ratios for 90Y- and 177Lu-based therapy, with the best candidate being hu3S193 I253A/H310A for 177Lu-based therapy. These results are highly relevant to utilising Fc engineering as a tool to improve the clinical application of hu3S193 and other intact antibodies especially for payload delivery.
This research was supported by National Health and Medical Research Council Project Grants 542512, 1030469, National Health and Medical Research Council Program grant 487922, National Health and Medical Research Council Practitioner Fellowship (A.M.S.), and in part by Ludwig Cancer Research, by funds from the Operational Infrastructure Support Program provided by the Victorian Government, and the Intramural Research Program of the NIH, National Cancer Institute, Centre for Cancer Research.
IJGB, LCA and DM engineered, produced and performed QC of the antibodies. IJGB, DM, DC and AR participated in all animal studies. IJGB, SG and GJO participated in data analysis of imaging studies and dosimetry. FTL and MWB were involved in radiolabelling chemistry and QC of radiolabelled antibodies. IJGB, ZL, PAR, AMS were involved in conception and experimental design, drafted the manuscript and critically revised the manuscript. All authors read and approved the final manuscript. | 2019-04-25T14:34:57 | https://ejnmmires.springeropen.com/articles/10.1186/s13550-016-0180-0 |
Diamond Foods Inc. completed its acquisition of Oregon-born Kettle Foods, the San Francisco based company announced today.
Under the terms of the agreement, Diamond paid Kettle's London-based parent, Lion Capital LLC, $615 million in cash for the snack food operation founded in Salem.
Kettle's all-natural chips, nut butters and trail mix are distributed throughout North America, Japan, Guam and Western Europe. It had sales of $235 million in 2008, according to Lion Capitals Web site.
The transaction was financed with proceeds from Diamond's recent common stock offering, borrowings under a new five-year $600 million credit line, and existing cash resources.
"The addition of Kettle Foods greatly strengthens our presence in the snack market," Michael J. Mendes, chairman and CEO of Diamond Foods, said today. "Kettle has been an innovator in the premium, natural potato chip category and is a brand which has demonstrated strong growth. We look forward to investing in the Kettle brand to further build its footprint."
Diamond Foods has focused on acquiring and building food brands that also include Emerald snack nuts, Pop Secret popcorn and Diamond of California nuts. | 2019-04-23T15:53:08 | https://www.oregonlive.com/business/2010/03/diamond_wraps_up_acquisition_o.html |
Under Mr. Mewburn's write up it mentions his funeral was in St. Catharines at St. John's Anglican Church Stamford. Are you certain you did not mean Stamford Township (now Niagara Falls). St. John's Anglican Church, Stamford isn't in St. Catharines. | 2019-04-18T20:39:27 | http://www.fenians150.com/blog/remembering-the-ridgeway-nine |
Marshmallow is a soothing demulcent that affects all mucous membranes. It is specifically indicated in inflamed, irritated, raw, sore, damaged and infected tissue states.
Marshmallow is native to most of Europe, where it can be found growing in salt marshes and damp meadows, river banks and coastal areas. The plant grows to heights of 1-1.5metres and has characteristically soft and ‘velvety’ leaves, covered in a thick layer of fine, soft hairs. The flowers are normally a light pink or white in colour. The marshmallow roots, which are often the portion of the plant used most extensively from a medicinal perspective, will produce large volumes of mucilage when they come into contact with liquid. It is this mucilage that is of vital importance when considering the medicinal value of the plant.
Marshmallow contains 11% mucilage which acts as its primary medicinal constituent. Mucilage will trap liquid to form gel like substances and will also swell to many times its original volume. Mucilage forms a protective layer over damaged mucosal membranes, allowing time for cellular regeneration and healing to occur but also protects membranes from further deterioration, for example, damage from gastric acid exposure. Higher levels of mucilage also encourages a healthy inflammation response, by allowing time for damaged cells to heal. Externally, the mucilage present in marshmallow performs a drawing effect upon the body’s tissues and can be particularly effective for removing fluid and toxicity from wounds and infections. In small dosages, mucilaginous compounds restrain the peristaltic action within the gut and work well to promote an antidiarrheal action. In larger dosages, they can promote a laxative effect.
The primary medicinal activity of marshmallow within the body is due to its high mucilage content. It is a key remedy for the provision of moisture and relieving symptoms and conditions of dryness. The qualities of marshmallow are characteristically moistening, soothing, cooling and calming. Marshmallow will increase internal moisture and reduce dryness, clearing internal heat and inflammation. Marshmallow has a particular affinity for the gastrointestinal tract but also proves effective for hot, dry and irritated conditions within the respiratory and urinary tract.
GIT: Indicated in all hot, inflamed, irritated and dry conditions of the digestive mucosa such as hyperacidity, gastritis, peptic ulcers and hiatus hernia. Marshmallow also acts as a bulk laxative in cases of chronic constipation and dry, pellet like stools.
Respiratory: Indicated in hot, inflamed, irritated and dry conditions of the respiratory mucosa such as unproductive coughs and tickly coughs. Marshmallow can help provide relief in conditions such as pneumonia and bronchitis by allowing time for the inflamed and infected mucosa’s to heal.
Urinary: Indicated in hot, inflamed, irritated and dry conditions of the urinary mucosa such as cystitis, urethritis, urinary stones and nephritis. Marshmallow will also help to protect the kidneys from the tracking of urinary infections and the development of more chronic long-term conditions such as interstitial cystitis.
Skin: Indicated in hot, inflamed, irritated and dry conditions of the skin such as wounds, burns, scar tissue, ulcers, lumps and swellings. Marshmallow can be applied externally to the skin to provide symptomatic relief and as a drawing agent, but can also be taken internally to help aid the healing and repair process.
The fruit produced by the marshmallow plant is often referred to as a ‘cheese’. Reflecting the disc-shaped, soft and hairy nature of the fruit. Althea actually means ‘to heal’ in Latin.
Virya (energy): Cooling Dosha: VPK= (K+ ama+ in excess).
Vipak (post-digestive effect): Sweet, salty, mildly bitter.
Guna (quality): Oily, sticky, heavy.
Dosha effect: VPK=, balances all three dosha.
Dhatu (tissue): Rasa/plasma, rakta/ blood, mamsa/muscle, majja/nerve, shukra/reproductive.
Srota (channel): Prana/respiratory, mutra/urinary, anna/digestive, majja/ nervous, stanya/lactation.
Mucilage (glucans, arabans, galacturonic rhamnans), asparagin, tannins, pectin, sterols, coumarins, flavonoids (kaemperfol, scopoletin, quercetin), coumarins, phenolic acids.
Wonderful rasayana for all 3 doshas. Strengthening & nourishing, soothes high pitta, reduces heat & inflammation in anna & mutravahasrotas; good for pitta type gut problems including diarrhoea & dysentery as well as for vata/pitta colitis, allergic rhinitis & coughs.
Grahi – reabsorbs fluid from the bowel, curbs diarrhoea.
Kasasvasahara – relieves coughs & breathing problems.
Kusthaghna – alleviates skin conditions.
Ojas vardhana – increases ojas.
Sara – eases the passage of stool.
Stanya – increases breast milk.
Sulaprasamana – relieves pain & spasm in the gut.
Emollient, demulcent, nutrient tonic, alterative, anti-inflammatory, expectorant, antitussive, analgesic, bronchodilator, diuretic, antilithic, rejuvenative, immunostimulant, galactogogue, antihistamine, vulnerary, antiseptic.
Use with licorice for pulmonary/respiratory based conditions associated with inflammation, irritation and dryness.
May reduce absorption of prescription drugs & supplements.
Dried Leaf/Root: 2-5g as an infusion.
Powdered Leaf/Root: 5% powdered leaf in an ointment base.
Tincture: 2-5ml daily 25% alcohol extract. | 2019-04-24T20:54:47 | https://www.herbalreality.com/herbs/marshmallow/ |
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