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Job ID: 99935 ERC-Funded Postdoctoral position in the Arenas Lab on Cell replacement for Parkinson’s disease Position: Post-doctoral Position Deadline: 28 February 2023 Contract Length: 2-4 years Institution: Karolinska Institute We invite applications for a postdoctoral position in the laboratory of Professor Ernest Arenas, http://ernestarenaslab.org/. The Arenas Lab is part of a strong and highly interactive research cluster in the Division of Molecular Neurobiology, within the MBB department, at the Karolinska Institute. The lab is located in Biomedicum, one of the largest and most modern research buildings in Northern Europe, which provides excellent research installations, and attracts top international researchers from multiple disciplines. As medical University, Karolinska Institutet conducts cutting edge research, holds the largest range of medical research and education in Sweden, is one of the world’s leading medical universities and is home of the Nobel Prize in Medicine or Physiology. We offer a full time (100%) postdoctoral position for 2-4 years, starting in 2023. You will be part of a team addressing fundamental questions about cell identity, you will use cutting edge technologies such as single cell RNA-sequencing or functional genomics, and you will advance experimental therapies to combat neurodegeneration. We offer a creative, inspiring, interactive and international research environment, where you can develop your career, enjoy science, and make a difference. The position is supported by a collaborative project of the EU (Neurostemcell-reconstruct, 2019-2024) and an ERC Advanced Grant (PreciseCell PD, 2021-2026). The project offers excellent training possibilities, outstanding research network and opportunities to interact and collaborate with other laboratories. As employer, Karolinska Institutet offers several benefits to its employees such as extended holiday, generous occupational pension, free access to a modern gym and reimbursements for medical care. We look for a highly motivated individual interested in cell engineering, cell replacement and Parkinson’s disease. The project is based on previous work from our laboratory providing proof of concept that conversion of somatic cells into midbrain dopamine neurons in vivo can partially rescue motor deficits in a mouse model of PD (Rivetti di val Cervo, 2017, Nature Biotechnology). We now propose to improve this method by engineering somatic cells into subtype-specific dopamine neurons. In this project you will take advantage of our pioneering work defining the developing human midbrain by single cell RNA-seq (La Manno et al., 2016, Cell), and our recent identification of factors important for the development and maintenance of adult midbrain dopaminergic neuron subtypes (Nishimura et al., 2022, Stem Cell Reports; bioRxiv 2022.10.24.513487 and 2022.10.12.511898). Your mission will be to develop a dopaminergic neuron subtype-specific replacement strategy that we expect will transform the cell replacement landscape for Parkinson’s disease. This project will involve work with viral vectors, cell culture, molecular and morphological methods, as well as single cell RNA-sequencing, CRISPR, functional genomics and/or stereotaxic surgery. You are a PhD about to defend your thesis or a Postdoctoral interested in transcriptional networks, cell engineering, dopaminergic neuron development, basal ganglia function, Parkinson’s disease and/or cell replacement/regenerative therapy. You have previous experience in working with one or more of the following: molecular biology, viral vectors, cell culture, immunocyto/histochemistry, electrophysiology, single cell RNA-sequencing, functional genomics, computational biology, stereotaxic surgery, gene therapy, rodent models of Parkinson’s disease. You have good communication skills and you are proficient in spoken and written English. Previous work experience in international environments will be advantageous. Please submit your application online at: https://ki.varbi.com/what:job/jobID:578864/ Applications should include your CV, publications list, 3 references and a letter describing your current work and motivation to apply. If you have any additional question, please contact: [email protected] Deadline: February 28th 2023
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Glandular Cytology of The Cervix: Diagnosis of CGIN/AIS and diagnostic pitfalls Dr. Tanya Levine | MA (Oxon), MBBS, RCDipPath(Cyto), FRCPath Consultant Histopathologist and Cytopathologist | Director of the London Regional Cytology Training Centre | London North West University | Hospital NHS Trust, UK This lecture will cover the key diagnostic features of high-grade CGIN / AIS and the diagnostic pitfalls that may be encountered in cervical cytology. Do not miss the opportunity. CEU's eligibility. Choose the suitable time slot and subscribe now:
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How to Install Adobe Flash Player to Open SWF Files Flash player is no longer supported or updated by Adobe. They no longer provide Flash Player installation files. Since there are no further security updates, major web browsers no longer allow playing SWF files either. But you can still use SWF.max Player to view Flash files and play Flash games! You will need to manually install Adobe Flash component. Instead of being installed system-wide, it will be installed locally just for SWF.max Player. This way your web browsing will remain secure and you can enjoy playing locally downloaded SWF files. TL;DR: obtain a copy of Flash.ocx ActiveX component (version 22.214.171.1241 or older) and place it in "C:\Program Files (x86)\SWF.max\Media\Binary" folder. How to Install Flash Player on Windows 10 or Windows 11 These instructions will work for any Windows edition, including 32-bit, 64-bit and ARM. Adobe, Adobe Flash and Adobe Flash Player are either registered trademarks or trademarks of Adobe Systems Incorporated in the United States and/or other countries. Other marks are property of their respective owners.
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Ethereum was the second digitalized coinage following the progression of bitcoin. The crypto enthusiast is aware that ethereum and other cryptocurrencies are availed by process of mining, all the more entire complex of every cryptocurrency is processed on a decentralized blockchain. The blockchain or the public ledger displays information regarding the transaction of ethereum. The core notion of the ethereum blockchain introduced the concept of smart contracts in the marketplace at the very first instance. These smart contracts are basically a set of codes demonstrating explicit information recorded in a specific block. The wide applications of the ethereum network in every industry are one of the prominent reasons for intensified demand for the currency. On Monday, ethereum halted the record of $4,000 first time ever in history. Here is everything that you need to know about the Monday sudden surge of let’s have a glance. Second Highest Market Capitalization! In London and Singapore, the second leading cryptocurrency, all the more current sizzling subject of the marketplace halted the record of $4,000 on Monday. The fact might astonish you that the recent highest price of ethereum was somewhere $3600, which was touched by the computerized coinage on Thursday. The market capitalization of bitcoin is the highest in the crypto marketplace at the instance. The total market capitalization of bitcoin was almost 70% till last fall. However, the sudden incline of ethereum has declined the market cap of bitcoin to just 43%. Moreover, bitcoin is steady on average price since the last week. The market cap of ethereum has grown by 6%; the market cap of ethereum is consistently rendering an exponential growth as the cap of ethereum grew 2% in the last week, at the instance of $3600 dollar price point. Ethereum is displaying a consistent growth; in contrast to bitcoin, the negative fluctuations of ethereum are just nominal, and ethereum has been performing for three days in a row since the last Thursday. Ethereum claims to equip ample of wide applications in tons of industry in contrast to the fellow cryptocurrency in the marketplace. It has ascended in 2021, the broader application of ethereum substituting the outdated traditional banking systems in the finance industry. The evolution of the financial industry into a decentralized finance system is one of the prominent reasons for the sudden growth of ethereum. Moreover, the technical fixes in the ethereum complex have restricted the supply of this leading cryptocurrency. The declined supply has emerged scarcity of ethereum as well, just similar to bitcoin, and scarcity is directly proportional to the demand of content. Moreover, the illiquid ethereum units are consistently rising as the transaction fees of ethereum trustable exchange keep rendering fluctuation. Conferring few robust sources, the ethereum improvement proposal, which is about to come live in July, is meant to mitigate the volatile nature of the ethereum tradable exchange forums. However, despite the technical issues in the network, ethereum has acquired an exceeding extent of institutional involvement in the network. Ethereum is considered as an actual cryptocurrency with ample applications in several institutions; all the more, it is not just a joke coin like dogecoin. The decentralized finance applications of the ethereum have all the potential of revolutionizing the finance industry, said few sources. The actual meaning of the term ethereum is the blockchain. Blockchain is a complex of blocks rendering facts and information regarding the smart contracts recorded on the ethereum network, transactions that occurred in the network. What About The Altcoins? Altcoins are basically other insignificant computerized coinage in the marketplace; one of the promising altcoins initiated as a joke is known as dogecoin. Dogecoin was invented in 2013; recently, the cryptocurrency climbed up to 700% of the actual price it was released on. The fact might astonish you that the market cap of Dogecoin is nearly $70 billion, and it is the fourth-largest market cap in the crypto industry. The dogecoin unit was noticed at a price of 0.72$ on the sudden surge of ethereum. Ethereum has halted the price point of $4,000 on Monday, which has shocked every crypto investor. Authentic platforms like this official website can assist you in getting some productive gains in your crypto journey. Follow Techdee for more!
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The New York Times is looking into the work of a reporter over similarities between a piece published last month and an article on Wikipedia. The response comes after MediaBistro’s Richard Horgan reported on Monday that a July 24 article by Times reporter Carol Vogel strongly resembles a portion of a Wikipedia page on Italian Renaissance painter Piero di Cosimo. In the lede of her piece, titled “A Renaissance Master Finally Gets a Showcase,” Vogel wrote: He is said to have been terrified of thunderstorms and so pyrophobic that he rarely cooked his food, subsisting mostly on hard-boiled eggs that he prepared 50 at a time while heating glue for his art. He didn’t clean his studio. He didn’t trim the trees in his orchard. Giorgio Vasari, the Renaissance biographer, described Piero as living “more like a beast than a man.” Vogel’s introduction is quite similar to a portion of Piero’s biography on Wikipedia: Reportedly, he was frightened of thunderstorms, and so pyrophobic that he rarely cooked his food; he lived largely on hard-boiled eggs, which he prepared 50 at a time while boiling glue for his artworks. He also resisted any cleaning of his studio, or trimming of the fruit trees of his orchard; he lived, wrote Vasari, “more like a beast than a man”. The Wikipedia page was last revised in May. Vogel has had some attribution problems in the past. Gawker’s J.K. Trotter noted that she was criticized three separate times last year by Modern Art Notes’ Tyler Green for failing to properly the cite the reporting of others. Times spokesperson Eileen Murphy told Trotter, “We’re aware of the situation and are looking into it.” When reached by TPM via email on Tuesday afternoon, Murphy said the Times had nothing more to add on the matter at this time. The questions surrounding Vogel’s work follow last week’s revelations of serial plagiarism by former BuzzFeed viral politics editor Benny Johnson, which were brought to light by a pair of anonymous Twitter sleuths. Johnson was fired late Friday after his editors found 41 instances of plagiarism during his time at BuzzFeed.
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Brits demand air conditioning while working from home27th August 2021 UK: More than 60% of British workers want their bosses to provide air conditioning while working from home, according to a new study by Andrews Air Conditioning. While it is known that productivity drops during hot weather, Andrews found that 44% of the 2,000 adults surveyed admitted that they struggle to stay on top of their workload when temperatures rise. Many refused to work when the heat has been too extreme, with a temperature of 28ºC commonly cited as being too hot for general exertion. As a result, 59% think their employer should have to provide them with air conditioning at home, as working from home becomes the new normal. A third of respondents have even put in a request with an employer – with a further one in five planning to do so. Nearly half were willing to contribute to the cost of having an air con unit to use at home – though 29% didn’t believe that was necessary. Of the four in 10 who don’t believe employers should have to provide air con for those working from home, 69% feel it’s not the responsibility of the firms to ensure their home isn’t too warm. And 54% simply don’t think the hot weather lasts long enough to justify such luxuries, according to the research carried out via OnePoll. The study also found more than half have ventured back into the office for a more pleasant atmosphere when temperatures have risen.
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Advanced Interventions for the Effective Treatment of Trauma, Anxiety, Pain & More New England Society of Clinical Hypnosis - This event has passed. New Rules for Treating Trauma- Sacramento, CA September 26, 2018 @ 8:00 am - 4:00 pm$229 New Rules for Treating Trauma: Integrating Neuroscience for Resilience, Connection and Post-Traumatic Growth Were you taught to use medication, CBT, exposure and other traditional therapy approaches to treat trauma? Did you know that these approaches can be limited when it comes to healing trauma at the deeper, emotional level of the brain? Memory reconsolidation is a recent neuroscience breakthrough that revealed a new way to clear trauma at its roots by process of recalling and updating a memory. During this 1-day seminar, I’ll provide you with step-by-step instructions and techniques you can use in each phase of trauma treatment. This is the trauma training that specifically gives you skills in the phenomena of memory reconsolidation. Let me show you why memory reconsolidation is necessary for transforming your trauma work with clients. I will give you a simple protocol to use to reconsolidate a traumatic memory in as little as one session! Don’t get the impression that you have to get lengthy, expensive training and certification in certain modalities in order to be able to successfully treat trauma. My workshop will let you walk away knowing exactly what to do to help your clients reclaim their lives after trauma!
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Picture this: a beautiful bride and groom, bathed in soft, ethereal light, surrounded by an enchanting atmosphere. What’s the secret ingredient that takes their wedding photos from ordinary to extraordinary? Crystal accents! These little gems have become the hottest trend in wedding photography, and today, we’re going to uncover the reasons why. Get ready to discover why crystal accents are the photographers’ secret weapon for capturing unforgettable moments. 1. Enhanced Elegance and Glamour Let’s face it—everyone loves a touch of luxury and glamour. Crystal accessories bring a dash of opulence to even the most mundane objects. Suddenly, a simple bouquet becomes a masterpiece, and a plain centerpiece transforms into a dazzling work of art. These shimmering gems have the power to elevate any element of a wedding, turning it into something extraordinary. Crystal accents have the ability to enhance the elegance and sophistication of wedding photography. They act as beacons of light, drawing the viewer’s attention to the intricate details and refined beauty of the occasion. 2. Reflective and Illuminating Effects Who doesn’t love a bit of sparkle? Crystals capture light like nothing else, creating mesmerizing reflective effects. As the sunlight dances on their surfaces, the atmosphere becomes alive with a magical glow. These illuminating effects not only enhance the mood of the photos but also showcase the radiant beauty of the bride, groom, and the entire venue. It’s like stepping into a fairy tale! Crystal accents act as miniature prisms, scattering and reflecting light in all directions. This adds depth and dimension to wedding photography, creating a dreamlike atmosphere. The interplay of light and crystal creates a captivating dance that is both ethereal and enchanting. 3. Symbolic Significance Crystals have a rich history and hold symbolic significance in many cultures. They are believed to possess healing properties, promote love and harmony, and ward off negative energy. By incorporating crystal accents into their wedding photography, couples can infuse their images with these positive and meaningful energies. Whether it’s a crystal-embellished veil symbolizing purity or a crystal-studded bouquet representing eternal love, these accents serve as tangible reminders of the couple’s commitment and the joyous energy of their union. Each photograph becomes a testament to the love and positive vibrations shared on their wedding day. 4. Versatility and Customization Crystal accents offer a world of customization opportunities for couples seeking to add a personal touch to their wedding photography. From the size and shape of the crystals to the color and setting options, couples can handpick the perfect crystals that resonate with their style and preferences. Whether it’s a vintage-inspired wedding with antique crystal details or a modern and minimalist affair with sleek and contemporary crystal accents, the versatility of crystals ensures that every couple can find the perfect fit for their aesthetic. 5. Complementing Wedding Attire and Accessories Crystal accents serve as exquisite embellishments for the bride’s attire, enhancing her beauty and radiance. From intricately beaded crystal bodices to shimmering tiaras and hairpieces, these accents elevate the bride’s look to a whole new level. The crystals catch the light as she glides down the aisle, creating a captivating aura around her. But it’s not just the bride who benefits from crystal accents. Grooms can also embrace the sparkle by incorporating crystal details into their accessories. A subtle hint of crystals on cufflinks, a lapel pin, or even a tie clip adds a touch of refinement and glamour to their ensemble. These crystal accents provide a harmonious balance between the bride and groom, ensuring that both partners shine brightly in their wedding photos. 6. Creating Mesmerizing Photo Opportunities As photographers, we’re always searching for that “wow” factor. Crystal accents provide endless opportunities for creative shots. Think of using crystals to create mesmerizing reflections or dreamy bokeh effects. These little gems can also be strategically placed to highlight details and create captivating focal points. With crystal accents in the mix, photographers can unleash their artistic vision and capture truly unforgettable moments. Crystal accents have a magical quality that can transform an ordinary photo into a mesmerizing work of art. “By strategically positioning crystals in the frame, photographers can play with reflections and refractions to create stunning visual effects. The crystals can capture the surrounding scenery or even reflect the couple’s love in a unique way,” note wedding photographers from 28 Wedding Films. In addition, crystals can be used to enhance the composition of the photo. Placing crystals as foreground elements can add depth and dimension to the image, drawing the viewer’s gaze to the intricate details and capturing their attention. Photographers can experiment with different angles, lighting techniques, and creative arrangements to maximize the impact of the crystal accents in their shots. The result? Captivating and awe-inspiring wedding photos that will leave couples and viewers breathless. 7. Trendy and Social Media-Friendly In today’s digital age, social media plays a significant role in how we share and celebrate special moments. Weddings are no exception. Couples want their wedding photos to make a splash on platforms like Instagram and Facebook, and crystal accents can help achieve just that. The shimmering allure of crystal accents is tailor-made for social media. Their captivating sparkle and reflective properties are eye-catching, making them instantly shareable and like-worthy. When couples incorporate crystal accents into their wedding photography, they create visual moments that are sure to grab attention as they scroll through their feeds. These sparkling gems add an element of luxury and sophistication that is highly sought after in the world of social media. Moreover, crystal accents are the perfect ingredients for creating viral-worthy photos. Whether it’s a close-up shot of the bride’s crystal-embellished veil catching the sunlight or a breathtaking reflection in a crystal-adorned centerpiece, these images are primed to become social media sensations. Through harnessing the power of crystal accents, couples can enhance their online presence, increase engagement, and create a lasting impression in the digital world. From transforming ordinary objects into extraordinary works of art to adding that extra touch of sparkle and shine, crystal accents have the power to elevate wedding photography to new heights. They bring depth, beauty, and a touch of magic to every frame, creating a visual experience that captivates viewers and immortalizes the precious moments of a couple’s special day. Iskra Banović is our seasoned Editor-in-Chief at BlueFashion. She has been steering the website’s content and editorial direction since 2018. With a rich background in fashion design, Iskra’s expertise spans across fashion, interior design, beauty, lifestyle, travel, and culture.
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For everyone from the serious Network Marketer to those of you just starting out in the Home Based business industry, and looking for premium training, we offer our Making Sales or Excuses and Home Based Business Training Course. Get the Making Sales or Excuses and Home Based Training right now for $500 One Time, or get the Home Based Business Training now while you make monthly payments for a total of $600. When paid in full, you'll have access to the Making Sales or Excuses Training. The Making Sales or Excuses course is held live twice per week and the Home Based Business Training once per week. You'll also have private access to Training Movies and Audio Files that you can download and listen to whenever you like. You'll get all this: - Your Own Phase3 Website Builder and Lead Capture Pages System for one year. - Access to both the Making Sales or Excuses and Home Based Business Training. - We will double your leads on your first order. - Free ad Listing on Youmongus Classified Ad Network, a $50 Monthly Value. - Access to every recorded call and video from the previous years, starting in 2011. - Access to training modules and scripts. - Option to become an affiliate and earn money by sharing our products and services with others. - Honorable Mention in MLM Who's Who. - Option to be a guest host on one Building Fortunes Radio show with Peter Mingils.
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Newswise — Researchers from Michigan State University released a study on “sextortion” – a lesser-known internet crime that poses a threat to adults and minors – that sheds light on the importance of protecting the public from online criminals. “Sextortion is the use of intimate images or videos that have been captured to then extort compliance from a victim,” said Roberta Liggett O’Malley, MSU criminal justice doctoral student and co-author of the study. “What makes it different from any other crime is the threat to release. A perpetrator could say, ‘I have these images of you and will publish them unless you…’ to get more images or even in exchange for money.” In many cases of sextortion, perpetrators don’t actually possess the images or videos they’re using as leverage. Instead, offenders manipulate victim behavior by tapping into the fear of not knowing whether the threat is real. The research — published in Journal of Interpersonal Violence — suggests the current focus on dissemination of images online may overshadow the issue of threat-based harassment online, like sextortion. While most U.S. states have laws against revenge porn, the study makes a case for increasing awareness and changing legislation to include other forms of internet-based sexual abuse crimes. “Much of the fear comes from the belief that hackers can do anything involving technology, from the ability to see someone’s web browser history to hacking into a webcam or Nest device,” said Karen Holt, assistant professor of criminal justice and co-author. “That's why sextortion is so effective — it creates a huge amount of uncertainty and fear that victims end up complying versus saying, ‘I think you’re bluffing, and if I ignore you, then I’m fine.’” Liggett O’Malley and Holt said men are less likely to report these crimes to police out of embarrassment or shame, but also don’t experience the longevity of harassment experienced by minors. “The victims are overwhelmingly minors and females, but if the objective is to get money, they’re almost always targeting men,” Liggett O’Malley said. “These two groups of people experience a similar crime in very different ways.” Analysis of 152 cyber sextortion offenders uncovered four distinct types: minor-focused, targeting victims under 18 years of age; cybercrime, targeting victims using computer-based tactics like hacking; intimately violent, targeting former or current romantic partners; and transnational, targeting strangers strictly for financial reasons. Holt explained that the four themes reflect different motivations for what offenders want from their victims. A survey of 1,631 cyber sextortion victims found 46% were minors, making crimes against minors a focus for law enforcement and in research literature. “The disproportionate focus on minor victims has led to new laws that protect minors from adult sexual solicitation online, but there are few legal protections for adult male and female victims,” Liggett O’Malley said. Researchers are starting to see sextortion being used by a lot of other perpetrators. Within a domestic violence context, partners may share images consensually, only to have those images later used as leverage in the relationship. In other instances, transnational organizations employ scams in which individuals pretend to be a man or women on the internet, engaging in webcam sessions with victims and immediately threatening to release a recording unless money is provided. Awareness and reporting of sextortion crimes, while acting responsibly online, are key in protecting adults and children. “As digital citizens, we have to start advocating for more accountability on behalf of platforms to take these images down, or to report harassment,” Holt said. “A lot of offline crimes have an online component, and oftentimes law enforcement and our behavior don’t catch up. We need to think about our own personal safety, both offline and online.” Researchers like Liggett O’Malley and Holt also advocate for federal laws to address the legal loopholes of sextortion. “We can’t only be focused on revenge porn,” Liggett O’Malley said. “We need to stop and think about all the ways in which images are used against people and to think about the way we construct these laws to ensure there are pathways for prosecution and arrest.” Note to reporters: please include link to paper in online coverage: https://journals.sagepub.com/doi/abs/10.1177/0886260520909186?journalCode=jiva
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A: Yes, under Pennsylvania sidewalk accident liability laws, property owners can be held liable for negligence in causing a trip and fall or slip and fall sidewalk accident. For example, a property owner could be held liable for failing to repair a piece of broken sidewalk concrete which causes a pedestrian to trip and fall. However, in order to be held liable, the property owner must have acted negligently (i.e., knowing about the broken concrete for weeks or months prior to when the accident occurred). In addition, under Pennsylvania government liability law, the local municipality or township where the accident occurred may be secondarily liable for the sidewalk. This means that both the property owner and the local government could be held liable for a sidewalk accident. However, you should speak to a knowledgeable Pennsylvania sidewalk accident lawyer immediately to discuss your case and your next steps. Read some tips to follow after a sidewalk accident in Pennsylvania. Related Pennsylvania Sidewalk Accident Legal Articles: - Pennsylvania Slip and Fall Law – Liability of Stores & Businesses - Pennsylvania Sidewalk Accident Law – Defendants in a Sidewalk Accident Lawsuit Pennsylvania Sidewalk Accident & Fall Lawyers – FREE CONSULTATIONS For more information, contact our Pennsylvania sidewalk accident lawyers at 215.925.4451. Our lawyers have over 60 years of combined experience and are available for a free, no obligation legal consultation. The lawyers at Schwartz & Blackman handle cases in the Pennsylvania and New Jersey area: - PA: Berks County, Bucks County, Chester County, Delaware County, Montgomery County, Philadelphia County, Allentown, Lehigh Valley, Norristown, Philadelphia - NJ: Atlantic County, Burlington County, Camden County, Gloucester County, Mercer County, Middlesex County, Monmouth County, Camden, Cherry Hill, New Jersey shore cities *This website does not provide legal advice. Every case is unique and it is important to get a qualified, expert legal opinion prior to making any decisions about your case. See the full disclaimer at the bottom of this page.
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Discover the Truth: Can You Really Uber Around Valencia, Spain? For anyone planning a trip to Valencia, Spain, knowing the best mode of transportation is crucial. With so many options available, it can be overwhelming to decide which one to use. One of the most popular options is Uber, but can you really Uber around Valencia? As a short or long-stay visitor or tourist, this information is crucial to make your stay comfortable and convenient. In this article, we will explore the truth behind Uber in Valencia and help you make an informed decision about transportation during your stay. A sprawling Mediterranean gem, Valencia blends timeless heritage with modern appeal. Central to its allure is the accessibility offered through a range of transportation choices, including the likes of Uber. But is Uber a practical solution in Valencia? Are there other viable transport options? Here's a detailed analysis. Uber in Valencia Today Uber does exist in Valencia, but with some restrictions. The car transportation service (VTC) operates through Uber Taxi (since November 2021) and its other options such as UberX, Uber Green, etc. that may be available in the city currently comply with the latest local regulations. These services offer a transportation experience available on demand with professional drivers and variable rates depending on the option chosen. Therefore technically it is true that you can use Uber in Valencia. Availability and Coverage One of the key factors to consider when determining whether Uber is a viable transportation option in Valencia is its availability and coverage. Unlike traditional taxis, which can be hailed from almost anywhere in the city, Uber's presence is not as ubiquitous. The number of available drivers may vary depending on the time of day, location, and demand. It's worth noting that during peak tourist seasons or major events, securing an Uber ride can be more challenging due to increased demand. Valencia’s Uber is facing legal battles due to the complexities of rideshare regulations. Latest news indicates that Uber is not officially authorized in Valencia, and the company operates in a legal grey area. Currently, Uber is only authorized to operate in Madrid and Barcelona, but not in Valencia. Valencia’s taxi industry has been protesting against Uber, claiming that the ride-hailing service is taking away their business. They argue that Uber is not following the same regulations and requirements as taxi drivers in the city. Despite the legal challenges, Uber continues to operate in Valencia, and many locals and tourists use the service. However, riders should be aware of the risks and potential legal issues they may face by using Uber in Valencia. Uber’s re-entry into Spain in 2016 included Valencia, the country's third-largest city. Despite initial regulatory challenges, Uber established a foothold with its UberX service, providing a modern, efficient mode of transportation for locals and tourists alike. Regulatory Landscape for Uber in Valencia Uber, along with other ride-hailing platforms, operates under the Spanish regulatory framework for VTCs (Vehículos de Turismo con Conductor), or Tourism Vehicles with Driver. The law mandates that VTCs can only accept pre-booked rides and are prohibited from picking up passengers hailing on the street. Alternative Ride-Hailing Services in Valencia Cabify: Spain's Own Ride-Hailing Powerhouse Providing stiff competition to Uber in Valencia is Cabify, a native Spanish ride-hailing service. With a stronger local presence, Cabify covers not only the city center but also suburban areas, offering everything from budget-friendly rides to premium services. Freenow: Another Option Available for Mobility in Valencia Freenow operates as a reliable and convenient alternative to traditional taxi service with professional drivers and competitive rates providing residents and visitors with an efficient and safe mobility option through its mobile application platform. BlaBlaCar: The Go-to Choice for Long-Distance Ride Sharing For passengers planning inter-city travel, BlaBlaCar is a worthy contender. This platform pairs drivers and passengers traveling in the same direction, offering an economical solution for long-distance journeys. Traditional Taxis: A Time-Tested Option Valencia's traditional taxi service remains a robust transportation option. Taxis are readily available throughout the city and offer the advantage of immediate, on-demand service without the need for pre-booking. They're regulated by local authorities, ensuring fare transparency and safety standards. Fare Comparison and Availability Uber, Cabify and Freenow fares are generally competitive with traditional taxis, although surge pricing may apply during peak times. These platforms operate round the clock, but availability in less central areas during late-night hours can be limited. Enhancing Your Journey: App Ease and Driver Communication Both the Uber, Cabify and Freenow apps are user-friendly, offering card payment options for a seamless ride experience. English-speaking drivers are common, simplifying communication for international travelers. Summing Up: Making Sense of Valencia's Transport Landscape Utilizing Uber in Valencia offers an efficient and comfortable way to navigate this bustling city. However, with solid alternatives like Cabify, Freenow and BlaBlaCar, and the ever-reliable traditional taxi service, you have a diverse range of transport choices at your disposal. By understanding these various options and their specific nuances, you can significantly enhance your travel experience in Valencia. So, whether you're planning a fleeting visit or an extended stay, make sure to explore these options to ensure smooth and enjoyable journeys in this vibrant city. Additional Considerations for Traveling in Valencia: While Uber, Cabify, and traditional taxis offer reliable transport options, there are some additional considerations to keep in mind for a seamless travel experience in Valencia. Timings and Rush Hour It's worth noting that peak hours in Valencia generally coincide with office start and end times, lunch breaks, and during popular events. If you're traveling during these hours, be prepared for potential surge pricing and longer wait times on Uber and Cabify. Exploring Further: Car Rentals and Public Transport If you're considering venturing beyond Valencia city, you might find a rental car more practical. Various rental companies operate in the city, offering a range of vehicles to suit different needs and budgets. For intra-city travel, Valencia's robust public transport network of buses, trams, and the Metro provides a cost-effective alternative. The city's bicycle-sharing program, Valenbisi, is also an excellent option for short trips and sightseeing. Another option available is Bike Rental, a very popular service nowadays offered by several private companies. Navigating Language Barriers Though many Uber, Cabify, and taxi drivers speak English, there might be some who are more comfortable conversing in Spanish. A translation app can come in handy in such scenarios to facilitate smooth communication. One of the significant advantages of ride-hailing services like Uber and Cabify over traditional taxis was their cashless payment system. Nowadays taxis also accept this payment method. This can be particularly convenient for tourists who might not always have the local currency handy. Although Uber is not completely available in Valencia, it is currently operational. However, it is important to note that these services may not be as widely available or affordable as Uber in other cities. Additionally, traditional taxi services are also reliable and readily available in Valencia. Ultimately, it is up to the individual to decide which transportation option best suits their needs and budget while exploring the beautiful city of Valencia. From the modern convenience of Uber to the reliability of traditional taxis, the versatility of Cabify and Freenow, and also the unique proposition of BlaBlaCar, you have a variety of transportation options at your disposal when traveling around Valencia. Understanding these choices and their unique attributes can help you choose the best option to meet your specific needs and preferences. Whether you're in Valencia for leisure or business, the city's diverse transport offerings ensure that you can make the most of your stay. By planning ahead and keeping in mind the various options and considerations we've discussed, you can ensure a smooth, efficient, and enjoyable journey through this vibrant city.
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Who am I? What am I doing with my life? I can relate. And I know one thing is for sure when you ask these questions: You feel like your current life circumstances are no longer enough for you. You have a beautiful life. … a lot to be thankful for. And you know this. But at the end of the day something’s missing. You don’t like how you’re showing up. … like you’re not putting your best Self in the game of life. Perhaps you’re impatient, late, indulging in bad habits and/or distracted by the latest online shopping deal of the moment. Whatever it is, you’re self-sabotaging. Distracting yourself from the very “Q’s” that linger on and on in your brain – Unanswered! Who am I? What am I supposed to be doing with my life? I hear these questions in my coaching practice often. And I am hearing them from everyone – even the people who seem to have “made it” BIG in life – on the outside. You are not alone. We all have moments where we question who and what we are, not matter where we’re at in life. If you find yourself in this place, you’re in search of purpose and meaning. Your soul is saying… I want to feel purposeful. I want to feel aligned. I have so much to be grateful for, and I just want to be clear that I’m on the right path. I want to be connected and in-sync with the people around me. No more conflict. But you’re left feeling like you have no idea how to do it. Any of it. That’s where I come in. If you are in this kind of “questioning phase,” you may be in search of Purpose and I’m going to help you discover it! What is a purpose? Before I show you how to discover your purpose, let’s define what a “purpose” really is… A purpose is a “knowing” that grounds you and anchors your actions in this life. Your purpose is your AIM. Once you identify your AIM – your actions will either be aligned or misaligned. 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They did not come to me to complain and stay “stuck.” At the time I was studying at Integrative Nutrition, healing from my disordered eating habits, and learning to build a Health Coaching business online. I thought becoming a Health Coach was it! And it was, for a period of time. Until I came back to that BIG life “Q” : “what am I doing what my life?” and I had to explore what was missing. I was not feeling fulfilled by offering nutrition support to people who seemed to be addicted to their stories. They weren’t getting the killer results I was hoping they’d get and I was not excited to show up for our coaching calls. This stuck energy wasn’t working for me. Through my questioning, I learned something very valuable here. I learned that I was being called to teach the very concepts that I myself needed to learn in order to feel whole, complete and healed as a human being. I learned that I needed to help people by teaching you how to: - forgive a family member - naturally overcome anxiety and depression - arrive at your perfect weight (even if that means putting on a few pounds) - live a purposeful life - consciously create your life circumstances from a place of possibility NOT control. - Start a passion project that allows you to express yourself creatively (and eventually turn it into your J.O.B) This awareness LIT me up. Almost as if I discovered a whole new Purpose. But it wasn’t. It was simply a NEW ITERATION or expression of ME within my Purpose. This was powerful! Your purpose will have layers. So, how do you get started on your journey? You start by getting curious and answering questions. Ask yourself 7 questions that point to your purpose. I want you to answer the 7 questions below. Write out the answers. Spend as much time as you can on this (but even 10 minutes is better than nothing)! Answer the questions… - What am I naturally attracted to? - What do I like to learn about? - What do I like to spend my free time doing? - What activities fill me up and cause my heart to leap with joy? (Healthy eating, photography, fashion, yoga, interior design…?) - What do I spend my free time doing? - What do I like to watch on tv or read in a book? - What is missing from my life? These questions are the beginning. They’re the beginning of the self-discovery process for you. They’ll lead you to learn about yourself. You’ll become more aware. Through this awareness, you’ll bring change. Take it slow. Be open. And most importantly, be kind to yourself.
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Day 27: Discernment I have my biases, and probably you do too. If you haven't already seen it, I recommend you watch "The Social Dilemma" to see how social networks affect our thinking in subtle ways. I am working on receiving news from different viewpoints to be able to discern the truth. 6 x 6 inches on 1/8 inch thick wood. Command Strips on the back allow damage-free hanging. Local delivery or free shipping in the U.S.
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It shouldn’t be a surprise at this point to anyone following This Is Darkness that Hærleif Langås is one of my very favorite dark ambient musicians. Just as it is with Pär Boström or Simon Heath, Hærleif’s music is rarely not included in any of my mixes and his albums, whether Northaunt, The Human Voice or Therradaemon his albums are in constant rotation in my CD player. Hærleif seems to have a natural talent for this kind of music, and that fact seems to be proven further and further with each of his releases. Night Paths is the first Northaunt release since Istid I-II in January 2015. But luckily in between these two releases we had the brilliant Silent Heart, by his project The Human Voice, which I might consider my favorite album of his to date, and the best album of 2016. To my great pleasure, the opener on Night Paths has a lot of similarities to a few of the tracks on Silent Heart. But it seems even more so to harken back to roughly a decade ago when Northaunt released their sophomore album Barren Land. The field recordings are bold and crushing, the instrumentation is straight forward and nothing like the subtlety we heard on Istid I-II. There is even a vocal sample incorporated into the track, reminding me of something like “Hopeless dreams” one of the bonus tracks from the Barren Land digibook reissue. Hærleif Langås mentioned, about a month before the release of this album, by way of a Facebook post, that these were unreleased tracks, a bit darker than the previous albums. While there is no real evidence to prove this, it sounds as if the album is laid out in chronological order. There is a slow progression across the length of the album from the harsher, bolder tracks from Barren Land and Horizons days, into something more like what we heard on The Borrowed World or Istid I-II. Though, right or wrong, this really doesn’t matter, it only shows that the album does have a sort of progression of sounds, whatever the reason. “Skjelletering”, the second track on Night Paths, is another one which is brutally dark and crushing. The drones are thick and chilly, the field recordings and samples adding even more depth to this darkness. “Blood Trail” becomes a much lighter affair following these two crushing openers. But the malign nature and abysmal darkness may have gone to an even more intense level. “Beneath the Ice”, a track that was introduced last month on our very own dark ambient compilation, becomes even more subtle. We get the sensations of a diver, searching some lost ancient shipwreck, beneath a thick layer of ice, which has kept the wreck sealed away from prying eyes for many years. This one is incredibly serene, and probably one of the least overtly dark tracks on the album. There are really so many great tracks here to talk about. The album seems to have spanned the career, or at least the second half of the music career of Hærleif Langås. There have been few, but incredibly great, albums from Northaunt over the years and it should be a real blessing to any fan of Northaunt, that we are able to take a step back and hear these outtakes which are anything but dispensable. Hærleif Langås decided to try something different with this album and released it himself, through his label, The Last Bleak Days. After so many years of releasing albums through various labels it doesn’t seem to be much of an issue for him to do this one himself. But, dedicated fans should take note that this is a limited edition release of only 150 physical copies in a 6-panel digipak. So if you are interested in the physical release, don’t hesitate, they might not be around for long! Night Paths is an absolutely worthy album to be added to the Northaunt discography. While it might not have the same stylistic and thematic consistency that we would hear on a proper full length, it’s full of great tracks, each one I am very pleased to have a chance to enjoy. We get a little something from all the different periods of the Northaunt sound, giving us a sort of time capsule back in time. For any fans of the older Northaunt music in particular, this is a must have. For newer fans, this is a way to get an idea of what Hærleif Langås has done in the past, a perfect introduction to his previous styles. Knowing that Istid III is right around the corner as well, we should all be quite content this winter, with plenty of fresh Northaunt music to act as a soundtrack to these upcoming cold, dark months. Written by: Michael Barnett
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Merrill Lynch has quietly rolled out yet another major chunk of technology that will, at least initially, most benefit the 15,000 advisors in its Thundering Herd, along with their clients and the firm’s client associates. The Collaborative On-Boarding Experience, or COBE for short, streamlines and fully digitizes the client account opening and onboarding experience (no more wet signatures needed). COBE’s overall development has been a years-long journey with more than 20,000 users across the country granted access to it since mid-April. Prior to that it had been in pilot with approximately 2,000 users beginning in mid-2020. What was once routinely a paper-based, week-or-longer process can now be completed in minutes if collaborating with a prospect or client, according to the firm. Similarly, in the case where a customer has at least a single account with the firm, a client associate should be able to open multiple other accounts on the client’s behalf, if requested, without having to bother the client for little in the way of initial data. And this means being able to open and manage accounts across the various wealth management groups within Merrill Lynch and, eventually, across banking services at Bank of America. “This one is one of the toughest nuts to crack,” said Kabir Sethi, head of digital wealth management for Bank of America, Merrill Lynch. “Taking that legacy process we have and digitizing it end to end where there can be multiple accounts is extremely hard—there is a lot of friction to work through,” he said, noting that the ultimate goal is to use this as an enterprise platform across the entire wealth business, digitizing workflows and integrating banking as well as the brokerage, ultimately eliminating forms (paper and digital). By year's end he said 80% of all wealth management account types should be available within COBE. “Clients can be completely hands off if they want and let the advisor and client associates do everything based on previous accounts, or the client can be far more involved in a collaborative process,” said Sethi. A major aspect of COBE that might go unnoticed by many is how it combines the client confirming their identity (“know your client” regulations) during onboarding, something that used to be two separate actions. “Anytime in this process we have the ability to send a request to the client [or prospect] to collaborate,” said Georgio Vuolde, who heads wealth management digital onboarding for Merrill and led an online demonstration of COBE. During the demo, he showed a hypothetical couple with one brokerage account who, having recently met with an advisor, now wanted to open five other accounts with the firm, including a CMA account, IRA, joint banking account and a custodial account. Posing as a client associate, Vuolde easily picked the account types from a menu and was able to ‘bundle’ them into a single account opening process. This automated workflow allowed the user managing the procedure to easily answer what they could with existing data or information and initiate a request to collaborate with the client for anything missing. Carrying out the same operation years ago would have required a stack of paperwork mailed or messengered to the client full of sticky notes indicating the need for additional information or signatures. While more recent digital iterations had simplified that process, it was often still siloed and form-based (even if digital). At the end of the action, the client associate (or other staffer) sees a playback, summarizing everything completed thus far. Collaboration requests can originate with advisors or client associates who may need additional information or who know that the client wants to be more involved. Initiating such collaboration simply requires a message to clients via their designated email address or through the platform if they are logged in. Also important is that clients will now have a single ID across their wealth, brokerage and banking accounts. Staff and clients alike, it should be noted, see the same view in the interface with the same data fields when collaborating. COBE has been built with responsive design, meaning that is available on a smart tablet, smartphone or desktop computer. This is just the latest technology addition in a years-long development rollout by Bank of America Merrill Lynch for its advisors and clients. In August 2020 the firm introduced its Personal Wealth Analysis technology that melded financial planning and asset management features and processes into a single experience. And most recently, in March, the firm rolled out its Digital Wealth Overview, composed of automated personalized, interactive video presentations produced for individual clients.
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Respect to Roy Hodgson. England can look forward to an excellent France 2016 tournament. What England needs to do, and perhaps in two years this will be accomplished, is to play a complete game at the level Italy plays. Not half a game, as it did on Saturday in Manaus. Roy Hodgson has, as England's manager, done something remarkable. He's nourished tactical smarts, picked young, talented players and turned down the volume of the tabloid-fuelled, delusional expectations that usually accompany England to any tournament. This 1-2 loss to Italy was a revelation. For 45 minutes there were periods, actual sequences of several minutes in length, when a person could think, "Crikey, England look crafty here." Against an Italy side relying heavily on Andrea Pirlo's exquisite passing, and tactical cunning, that was a fine accomplishment. As a unit, England looked comfortable in possession of the ball. The game unfolded at a stately pace. The plan, it was clear, was to stay calm and if possible, get the ball to young Daniel Sturridge, who was superb throughout and who levelled the game, meeting a beauty of a pass from Wayne Rooney. That was in the 37th minute and at that point England appeared to be Italy's equal. Come the second half, things went awry for England. To some extent Rooney was to blame. He seemed unsure of his role and position. But in general the disappointment came from the performances by the substitutes, the heavily hyped Jack Wilshere, Adam Lallana and Ross Barkley. Followers of the English Premier League will know the names – skilled youths with a bright future already written in neon by exitable pundits. However, here, all seemed clueless about structure and creativity. And that's the missing element. They were guileless. (The tally was 18 shots on goal for England and only five on-target.) But guile is something the starlets can learn. For years there has been a peculiar dynamic in the England set-up. Egos and bad attitude have thrived when England is playing away at a tournament. At the World Cup in South Africa, some England players famously declared they were bored with the isolation. At Euro 2012 in Poland and Ukraine, there was no such controversy. Instead there was just the matter of being utterly outclassed and looking desperate against Italy in a knock-out game. On Saturday, at this World Cup, in a rematch, England didn't look desperate. A startling improvement on two years ago. And didn't seem outclassed for half the game. That's Roy Hodgson's achievement. Give it another couple of years and, well, England can surely take the next crucial step away from utter mediocrity and present a challenge to a team such as Italy. As for Italy, it will surely play tougher games than this one. That is, in the next round of the World Cup. Next it faces Costa Rica and then Uruguay. Both are beatable. Italy's two goals against England illuminated its sophistication. The first was a little masterpiece of shrewdness. Claudio Marchisio drove the ball hard from distance and was able to do so thanks to Pirlo's canniness. From a corner, the ball was aimed at Pirlo's feet but he dummied, allowing Marchisio time and space. For the second, Mario Balotelli headed home from close range at the far post, meeting an Antonio Candreva cross that was perfectly weighted and timed. In fact Candreva hounded England all night, easily finding space as they looked confused about how to stop him. Balotelli could have had three goals. His speed and intuition scarily sharp. Wisely, from Italy's point of view he was substituted right at the moment when his legendary temper seemed about to flare. Group D at this World Cup is now Italy's to own. Costa Rica's surprising win over Uruguay can be explained by speed, energy and flashes of panache. Uruguay, lacking Luis Suarez, seemed dull-witted and slow-moving. It's hard to believe Costa Rica can do the same to Italy and it seems unlikely that Suarez, should he be fit to play, can save Uruguay's campaign now. His skills are phenomenal, but he's human, not a super-hero who can instantly heal from injury. England's World Cup is probably, in truth, over. It lasted an excellent 45 minutes, really. But England's supporters can look forward to a more satisfying tournament two years from now. Respect to Roy Hodgson for that. Editor's note: An earlier version of this story misspelled Jack Wilshere's name. This version has been corrected.
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Day after day our heart experiences dozens and hundreds of interactions: with others, with news stories, with our thoughts, or avoiding our thoughts. All these interactions evoke a response from us, and take root for better or worse within our hearts. Think of our hearts as fields where there is continuously something happening. The responses those interactions produce is determined by whether we are our own farmer or Jesus is the cultivator of our heart, the farmer of our soul. We spend time thinking about all kinds of things, or avoiding thinking, filling our time separating ourselves from things we think will cause pain, heartache, irritation. We were meant to be integrated, in communion with God. Instead we find that pain and evil break through moment by moment into our soul, leaving us at the mercy of everything that happens. Jesus brings us back into communion with God, and helps restore the walls of our heart, shielding us from pain and evil. That only happens if we continually walk with Jesus. (adapted from Dallas Willard, Renovation of the Heart) Restoration of our heart’s communion with God requires the divine intervention of the Holy Spirit. Like a field cultivator (a tool used in farming)--we open the field of our heart to Jesus, since only he can prepare a proper seedbed for the Holy Spirit to be planted into--the daily set of experiences, so that our thoughts, reactions--the fruit of those interactions, are fruit of the Holy Spirit, and not gnarly, malformed, rotten fruit. We want thriving, Jesus-modeled responses (fruit), and not prickly, cutting, destructive weeds that stick to others. This requires daily vigilance--to ensure the vines of jealousy, doubt, & selfishness don’t cut off the life of our relationships. Jesus as cultivator ensures weeds are killed, and that there is room for water, nutrients--creating space to breathe. - What a heart cultivated daily, habitually obedient to Jesus looks like. - Psalm 1 Blessed is the one who does not walk in step with the wicked or stand in the way that sinners take or sit in the company of mockers, 2 but whose delight is in the law of the Lord, and who meditates on his law day and night. 3 That person is like a tree planted by streams of water, which yields its fruit in season and whose leaf does not wither—whatever they do prospers. 4 Not so the wicked! They are like chaff that the wind blows away. 5 Therefore the wicked will not stand in the judgment, nor sinners in the assembly of the righteous. 6 For the Lord watches over the way of the righteous, but the way of the wicked leads to destruction. - What our hearts look like without Jesus turning over, refreshing the soil, when we try to be our own cultivator and adhere to rules; the ground is hard, and the seeds stay on the top of the soil, and get washed away, never producing healthy plants & fruit. - Jeremiah 6:16 This is what the Lord says: “Stand at the crossroads and look; ask for the ancient paths, ask where the good way is, and walk in it, and you will find rest for your souls. But you said, ‘We will not walk in it.’ - Psalm 14:2-3 The Lord looks down from heaven on all mankind to see if there are any who understand, any who seek God. 3 All have turned away, all have become corrupt; there is no one who does good, not even one. - The process of Jesus daily cultivating our heart. - Romans 14:17 For the kingdom of God is not a matter of eating and drinking, but of righteousness, peace and joy in the Holy Spirit, - Psalm 16:8 I keep my eyes always on the Lord. With him at my right hand, I will not be shaken. - Proverbs 4:23 Above all else, guard your heart, for everything you do flows from it. - 1 John 3:14 We know that we have passed from death to life, because we love each other. Anyone who does not love remains in death. - John 7:17 Anyone who chooses to do the will of God will find out whether my teaching comes from God or whether I speak on my own. - Deuteronomy 4:9 Only be careful, and watch yourselves closely so that you do not forget the things your eyes have seen or let them fade from your heart as long as you live. Teach them to your children and to their children after them. - Matthew 11:29 Take my yoke upon you and learn from me, for I am gentle and humble in heart, and you will find rest for your souls. - Galatians 5:24 Those who belong to Christ Jesus have crucified the flesh with its passions and desires. - What it looks like when our heart is cultivated by Jesus. - 2 Corinthians 3:18 And we all, who with unveiled faces contemplate[a] the Lord’s glory, are being transformed into his image with ever-increasing glory, which comes from the Lord, who is the Spirit. - John 13:34-35 “A new command I give you: Love one another. As I have loved you, so you must love one another. 35 By this everyone will know that you are my disciples, if you love one another.” - John 14:21 Whoever has my commands and keeps them is the one who loves me. The one who loves me will be loved by my Father, and I too will love them and show myself to them.” - Luke 10:25-29 On one occasion an expert in the law stood up to test Jesus. “Teacher,” he asked, “what must I do to inherit eternal life?” 26 “What is written in the Law?” he replied. “How do you read it?” 27 He answered, “‘Love the Lord your God with all your heart and with all your soul and with all your strength and with all your mind’[a]; and, ‘Love your neighbor as yourself.’[b]” 28 “You have answered correctly,” Jesus replied. “Do this and you will live.”
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Skip to content ADDIE’S Way Campus Tour Welcome to the paws4people National Headquarters Tour! Our tour will start in our RILEY Admin Building and after a 30–45-minute presentation about paws4people, we’ll walk down to the BRIELLE Puppy Development Center to visit some of our youngest Assistance Dogs In-Training. Please wear comfortable shoes/clothes as we will be seeing future Assistance Dogs in Training. We look forward to seeing you on the Tour! Click Here to sign up for this tour.
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PETER SALEM: A BLACK INNOVATOR Peter Salem, a black revolutionary soldier, was freed by his master so he could enlist in the Massachusetts Minutemen, is the. In spite of the unlimited hardships placed on slaves in the 17th and 18 centuries, many rose above them to make great contributions to the growth of the new nation. America: Discover Peter Salem’s contribution below. THE PAINTING: BATTLE OF BUNKER HILL Below: Take a look at a painting made by an artist. It focuses on Thomas Grosvenor, a British Army Officer, as the subject of the painting. It was not Peter, even though he was the hero. Salem fought with his company in the Battle of Bunker Hill. According to Samuel Swett, who chronicled the battle, Salem mortally wounded British Marine Major John Pitcairn who died from a musket shot. PICTURE OF PETER AND GROSVENOR Peter Salem: Unrecognized Grandeur The man holding the sword is Thomas Grosvenor. He is not the hero. This writer views this as an example of how the contributions of blacks were demeaned or erased. COMMENT OF A READER “The man who was the hero of the moment was placed behind the man with a sword, who did not fell the enemy….Salem did.“ But Grosvenor became the subject of the painting, unless I am missing something about his importance to the event. From the entry we read, it would seem that Salem was the hero of the moment, but is given a secondary place in the painting.“ RESPONSE TO COMMENT “I agree with you … (Salem was the hero) but the painting was done in the late 18th century (1787) when slavery was still “live and well” in America. The artist obviously felt he could not bestow that kind of honor on an ex-slave. As the article states, in 1775, President Washington was not allowing African Americans to fight in the Union Army. It was only in 1783 when he allowed that to happen. Also, most of American society believed that “the slave always walked behind his master.” The picture typifies that thinking, while still trying to give credit to the ex-slave. You are very perceptive! Thanks.“ PETER WAS A HERO Additional Information: I believe the link below leads to clarification by another writer of the painting in the article on Peter Salem … please read it. The clarification reveals the painting did not depict Peter Salem at all, but a servant of Grosvenor. AMERICA DISREGARDED A BLACK REVOLUTIONARY SOLDIER Again I repeat … “we are what we believe!” The great part about all of this is … we can change what we believe! That change starts with self-analysis — “An independent, methodical attempt to study and comprehend one’s own personality, emotions, and behavior.” If you don’t like what you see, work to change it. If you like what you see, ask yourself if what you see is how you would like others to treat you. Lying or self-justification are key elements of thought that have to be removed, if change is to occur.
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PROFESSIONAL MUSIC LESSONS L A School Of Music offers private music lessons to the people of Selkirk, MB. You can be assured to receive instrumental training from experienced professionals. L A School Of Music is the right place to start your musical journey in Selkirk, MB. We offer private music lessons for all age groups. You can be assured to receive quality training from professionals. We specialize in the sale and services of accordion. Whether you are a novice or a trained musician, you can always hone your skills with us. You can choose to take lessons for drums, piano, keyboard, organ and much more. Apart from this, we also offer voice lessons. You can rely on us for all your music supplies, instrument rentals, services as well as repairs. We are an exclusive Roland accordion dealer in Selkirk, MB. We strive to make your musical foundation strong so that you can nurture your musical talent. For us, there is no age to learn music, because all you need is the passion for music. We carry various musical instrument brands like Hohner, Titano among others. So that you can choose in accordance with your preferences. Looking for bass guitar lessons? Enroll with us today. Private Music Lessons Products and/or Services
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Effective leadership relies on the ability to ask strategic questions and actively listen to the responses. Leaders today play a pivotal role in fostering strong work relationships, boosting team morale, and enhancing overall performance. To become a successful leader, it’s essential to utilize this potent communication tool, which not only uncovers crucial insights but also strengthens connections within the team or organization. When team leaders engage in open, non-leading, and uninterrupted questioning, valuable insights into team members, and the vision and mission of the team can emerge. Questions To Ask A Leader Here are some leadership questions to ask leaders that can empower them in their leadership development and role: - “What is it that you’d like to see accomplished and how do you see it happening?” - “What are your thoughts? Your concerns?” - “What’s the most important priority to you with this and why?” - “What would you like to see improved?” - “Can you help me understand your thought process a little better?” - “What’s in the way of improved performance? How can I change that?” - “If I could change one thing as a senior leader that would have the greatest impact, what advice would you give?” - “What prevents our team from being able to place more focus on this? How is time management?” - “What self-limiting fears, thoughts, or actions do we want to leave behind?” - “Are my actions today compatible with what I wish to leave behind as a legacy in my leadership position?” - “What is my leadership style?” - “What are our core values as a team?” - “How can we achieve more work life balance?” - “Is every team member being heard?” Asking these strategic questions can be a valuable step in the journey of personal and team development. Encouraging teams to contribute their strategic questions to ask senior leaders can also promote a culture of collaboration and continuous improvement and boost employee morale. It allows leaders to grow and develop to become role models and understand effective leadership styles. By consistently using these questions in leadership conversations, senior leaders can gain valuable insight, enhance their communication skills, drive positive changes, create a positive work environment, and inspire career growth for themselves and their team. Encouraging employees to ask questions is a vital aspect of improving leadership morale within an organization. When employees feel empowered to inquire and ask leaders for clarity, it creates an atmosphere of openness, trust, and transparency. The result is not only improved employee engagement and decision making, but also a stronger alignment with the organization’s mission, which ultimately leads to the development successful leaders and more robust work relationships. These are key leadership skills required to be an effective leader. “The greatest leaders are those most interested in surrounding themselves with assistants and associates smarter than they are.” – John C. Maxwell This quote by leadership role expert John C. Maxwell emphasizes the value of senior leaders seeking out and listening to employees and team members who bring diverse skills and perspectives to the table. It highlights the importance of humility and a willingness to learn from others to achieve success in leadership and improve leadership abilities. As today’s leaders aim to enhance their leadership effectiveness, it’s crucial to recognize that asking the right questions is a powerful tool that can foster personal and team growth and understand other’s thought processes. Adding questions about strengths and weaknesses to the list can further promote self-awareness and create an environment of mutual support and development, and help one become a better leader in their leadership role. These questions not only open the door to understanding what leadership qualities one already has, but also where they can grow as a leader. Asking questions clarifies team goal setting. It helps with conflict resolution, invites great ideas that would oth犀利士 erwise go unheard. The journey to being a successful team leader is marked by an unwavering commitment to team growth, career development, and the cultivation of stronger work relationships where team members support each other, ultimately driving improved performance and morale. Take notice of your results. If these questions start to open the door to more powerful communication (which we know they will) – start making them a new leadership habit and become a better leader.
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DHEC takes its role of protecting public health and the environment very seriously. We welcome the opportunity to have meaningful dialogue with all of our stakeholders as we continue our efforts with this complex project that affects a unique and beloved natural resource of our state. We encourage interested persons to stay involved by attending meetings, asking questions, and submitting comments. On March 30, 2022, DHEC held virtual community meeting to discuss the next phase of environmental cleanup for the Congaree River Sediments Site. DHEC will provided new information and a projected start date for the cleanup of tar-like material located downstream of the Gervais Street Bridge. The presentation and a recording of the meeting are available below: On November 17, 2020, DHEC held a virtual community meeting to discuss the cleanup of tar-like material. At this meeting, DHEC provided additional details of the Modified Removal Approach, which is the preferred cleanup method, and outlined the next steps for the project. DHEC staff, the Congaree Riverkeeper, and representatives from Dominion Energy also answered questions from meeting attendees. The presentation and a recording of the meeting are available below: On April 2, 2019, DHEC held a public meeting to discuss the Conceptual Plan for the Modified Removal Approach. This plan was developed through the cooperative work of SCE&G (now Dominion Energy), DHEC, and community stakeholders. The Conceptual Plan for the Modified Removal Approach and other resources are available below. On March 21, 2013, DHEC held a public meeting to discuss the Full Scale Removal of the TLM and Impacted Sediments. On February 13, 2017, DHEC held a meeting and presented information on the status of the Congaree River project and the evaluation of an alternate removal approach. - February 13, 2017 - DHEC Presentation at Community Meeting - February 13, 2017 - DHEC Hand-Out at Community Meeting Future updates and additional information will be provided on this webpage as it becomes available. You can also sign-up to be on our mailing list.
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What Happens in the Brain During ASMR? - Published14 Oct 2021 - Source BrainFacts/SfN For some people, soft sounds and gentle touches trigger pleasant tingles in the scalp and neck — a sensation known as ASMR, or autonomous sensory meridian response. Scientists are learning what happens in the brains of people who experience ASMR. Storyboard and animation produced by Midnight Snacks for BrainFacts.org. Scripting by Chia-Yi Hou. Scientific Review by Craig Richard. CONTENT PROVIDED BY [Whispers] Gentle whispers in your ear, fingers tapping [soft tapping] softly on a table, light touching of your hair [light brush] … if these moments give you tingles [exhale] on your scalp and neck, you’re having an autonomous sensory meridian response [flickering lights], known as ASMR [woosh]. It happens in response to gentle stimuli during a moment of positive, personal attention. People who experience ASMR [illuminating jingle] may feel a pleasant, calming “tingling” sensation on their scalp and neck [woosh]. But not everyone has this experience, and people react differently to different ASMR triggers. During ASMR, [swish] various parts of the brain increase in activity [illuminating jingle]. These areas include regions for processing rewards and emotional arousal, like the nucleus accumbens and insula. Another specific area that can also get activated is the medial prefrontal cortex, which is involved in processing social behaviors and emotions [indistinct chatter]. Scientists aren’t quite sure why some people experience ASMR and others don't. Perhaps, there are differences in how brain regions [woosh] are connected, or differences in the number and sensitivity of cells across our brains. But whether you get the tingles or not, you may still enjoy the soothing nature of ASMR triggers. [Light splash, swoosh, light splashing]
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P360 Franchise Group: Announces New Mira Mesa Location Performance360 Franchise Group announces new location coming soon to Mira Mesa, San Diego. This location will be owned and operated by our very own Cody Goyette and Jenn Ciofolo, supported by additional P360 member owners Mark Fleury, Guy and Jen Whetstone. We’re thrilled to continue to see our coaches carry the brand flag into their own ownership experiences. Target opening is early 2023.
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Nutrition has to be healthy and has to make you full of energy, especially if you’re still growing a learning. Instilling good eating habits in kids, teenagers and college goers, who are on the go, growing and in need of as many vitamins and nutrients as possible is not easy, but it can be done. So have those kids put aside those thoughts of bringing in the best writing service to complete their school work for them and have them read this useful article to become a healthy student. Keep a healthy diet following the simple tips below to feel good and manage your weight easily. Avoid Junk Food Junk food is popular among students because it is delicious and can be cooked fast. However, you cannot even imagine how bad this food is for your digestion. Junk food is high in fat, salt, sugar, low in fibre and nutrients. Therefore, what is the purpose of eating it? The most widespread health problems caused by junk food include high blood pressure, weight gain and heart attacks. Many teenagers eat junk food every day. This might be sugar-sweetened drinks like fizzy drinks and high-kilojoule snacks like potato chips. However, your body can’t run properly on poor fuel. Change Your Thinking Try to compare the prices of healthy food and junk food and you will see that healthy food is a cheaper option. Use different recipes and foods to see that the healthy food can be super delicious. Do not think that a diet means eating the small portions. It is not true! Moreover, sometimes you can even treat yourself, for example, eating one chocolate muffin a month. More Useful Tips - Stop drinking sugary drinks because they usually effect on bones and teeth in a negative way. Better drink water. To make the taste of water brighter, consider adding a slice of lime or lemon in it. - Eat breakfast every day. A good breakfast should include at least vegetables and meat/fish. However, if you do not have enough time to cook in the mornings, then eat some yoghurt or whole meal toasts. - Make a fruit bowl and put it on the table in your dorm. Grab some fruits while you are at home! - Lunch and dinner should not be skipped. Eat three times a day to be healthy and happy. - Boil instead of frying. - Buy small plates instead of big ones. Numerous studies have shown that the bigger plate is the more food you eat. - Try not to add salt to your dishes. - Do not eat high-fat foods if you are going out with your friends. Even fast food chains have the healthy options in their menus. - Adding superfood supplements to your diet is an excellent way to augment your intake of essential nutrients that your body needs to operate at its best. While a healthy diet is critical, incorporating superfood supplements into your routine can provide an extra dose of vitamins, minerals, and antioxidants that may be lacking from your meals. Who can help you? There are many people available to help you get your diet on the right track and keep it there. These may be your personal doctor, dietitian, friends and parents. All in all, you have to remember that it is very important to keep the healthy diet during education. Healthy meals and snacks can not only boost your productivity but also make your body healthier. Good luck!
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You have your location, now choose your cuisine – Swiss or Thai, or the best of both worlds. We will ensure that you can relax and entertain your guests in comfort and style. Our catering service delivers everything – furnishings, lighting, decoration, entertainment, infrastructure, personnel, crockery and cutlery. And all that for up to 1000 people. Our venue is bright and generously proportioned, thus allowing us to be flexible with the right space to suit the size of your party; we can accommodate up to 180 people, and the setting can be transformed – for whatever the occasion – from festive banquet to vibrant ballroom. Idyllic outdoor areas, such as the Panorama Terrace or the hotel rooftop terrace, are breathtaking locations for aperitifs or small parties; with these settings a memorable occasion is assured. We will gladly create individual menus or themed buffets, and organise the appropriate decoration and all the trimmings in your chosen colour. What a way to start married life! Celebrate your most special day in the midst of this glorious scenery. And completely uniquely: arrival by carriage, boat or limousine. Lakeside aperitifs at the romantic beach house “Wilerbadli”, or on the Panorama Terrace. Thereafter, we will pamper you and your guests with delicacies of your choice from our two restaurants. Celebrate and dance until late into the night. For the perfect end to your magical day, our romantic wedding suite awaits you, with a four poster bed and its own balcony. We are happy to arrange contact with our professionals: musicians and entertainers, photographers, decorators, florists. We are accomplished all-round wedding planners, but would also be pleased to work together with you in the organisation. We are pleased to give you a personal insight: Video from “Hochzeits DJ” at the Wilerbädli
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Emma, Dan and the rest of the Harry Potter cast is in hysterics as they are filmed for a new feature saying goodbye on their last day of filming Harry Potter and the Deathly Hallows! As sad as watching the final installment of the Harry Potter series may have been for fans, it seems like it was even harder for the cast. In a just released video, cast members Emma Watson, Daniel Radcliffe, Helena Bonham Carter, Rupert Grint and more can be seen giving a tearful farewell on their final day of filming. Awwwww! Watch the video above and let us know, are you sad that Harry Potter is over? Click Here For More Pics From ‘Harry Potter!’ Craving More On Kristen and Rob? Click Below!
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Well we floated the Clinch, put in at peach at 11 and pulled out at 61 around 715. Had a great day. My buddy who hadnt fly fished since he was in middle school. Caught 7 or 8. I caught i don't know how many. With a couple of good sized fish. Had one really good one break off right below cold water farms. All fish came of bhpt and midges. With more being on the pts. Hey even seen a few sulphers but the fish wasnt on them at all. All and all I think I made the right move by fishing the Clinch. I look like a lobster though.
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"You know the drill with the Bluefly wall." Yes, Tim, they do. And we feel you. We all know the drill with this show too, and you know what? That drill needs to go a hell of a lot faster. How is it possible that there are still 8 (now 7) designers? Let's cut to the chase, Bunim-Murray Productions. It's going to be Maya, Seth Aaron (he's just soooo Seth Aaron, you know?), and either Emilio or Jonathan, right? And Anthony will stick around as long as possible, obviously. Just get on with it. All these Garnier Elements and L'Oreal Paris Neighborhood Inspirations challenges are just killing time that, frankly, feels already dead. Do we really need to see the East Village in clothing form sponsored by L'Oreal? That's what H&M is for! Collier Strong built an entire L'Oreal store display in the make-up room, and made all the designers pretend to shop there for no reason! Anthony is running out of sassafras! All this dawdling is wasteful, unnecessary, and above all tiring. You've exhausted Tim Gunn with this bullshit. Could you not hear the double dose of exasperation in his voice tonight? There needs to be a double (or triple) elimination soon, or by next week Tim is going to walk into the workroom on the day of the runway show and say, "Designers, you have....ah fuck it." then turn on his impeccable heel and walk out. And who could blame him? There should have been a double elimination in tonight's episode. If God ran this show instead of Bunim-Murray Productions, there would have been a double elimination in tonight's episode (because God can be merciful; Bunim-Murray Productions just want to keep the hamsters running in the wheels forever). Working in pairs = double elimination. Those are the rules. But there wasn't a double elimination tonight, instead there was a double win—which is such a cop out. So let's talk about that winning pair and the rest of the pairs. Tonight's pairs challenge was to create a daytime look and a nighttime look inspired by L'Oreal Parisienne Collier Strong's ironically craggy face and an NYC neighborhood. Shockingly, Murray Hill wasn't one of the neighborhoods, and so we didn't get to see Bangs The Elder attempt colorblocked chinos. Instead, Anthony and Bangs The Younger traveled to Chinatown; Emilio and Seth Aaron gawked at people on the sidewalks of Harlem; Jay and Bangs The Elder scored some horse around Tompkins Square Park in the East Village; and Jonathan and Amy skipped around the Upper East Side and tried not to mention Gossip Girl. Not surprisingly for a pairs challenge, the results were completely mixed. All the pairs created some seriously horrendous stuff, and so mediocre was somehow taken for sublime. Case in point: Anthony and Bangs The Younger's "non-literal" take on Chinatown. I wholeheartedly approve of the fact that they didn't want to go for the obvious golds and reds, but overall their looks were ho-hum at best. Anthony's cocktail dress wasn't so bad. The "tissue paper" detail was interesting, even if it did kind of look like he had strung big ribbons of tripe from her shoulder to her hip. But Bangs The Younger's "pagoda jacket" with the cut-out detailing on the sleeves paired with that red-accented skirt just looked like one of Melanie Griffith's rejected costumes from Working Girl. They should have styled that model with pantyhose and tennis shoes. Naturally, the judges loved it. Anthony and Maya were in the top two. But they weren't the double winners. No, that (historic!) honor went to Emilio and Seth Aaron's Harlem looks. For nighttime, Emilio made an old-tyme, Cotton-Club-inspired gown with a zipper down the front. For day, Seth-Aaron made a denim jacket horrorshow that displayed 75 contrast-stitched seams and darts, 15 rivets, 23 buttons, and two tails (all denim detail counts are estimated). He probably also wanted to make distressed patches and sew them on the back of the jacket in a random pattern, but Emilio somehow talked him out of it. I have no idea what Seth-Aaron made on the bottom for his model (looked like skinny jeans?) because the camera stubbornly refused to do a full-length body shot for more than .075 seconds, but he apparently made some kind of a shirt in a print that the judges adored, which made complete sense because only 2 inches of that print shirt were visible. He also put his model in an unfortunate hat and made her wear a solitary earring because, uh, Harlem? Seth Aaron and Emilio won because, uh, someone had to win? And the winners weren't going to be Jonathan/Amy or Jay/Bangs The Elder, that's for sure. Personally, I didn't find Amy's peachy "umbrella" of a shirtdress as egregious as the judges did. It certainly wasn't "ugly"—a little misguided, a little cheap-looking, yes, but not ugly. But their assessment of Jonathan's taupe cut-out dress was spot-on: the brown panels on the sides killed the look of that dress. Representin' tha East Village, Jay and Mila's concoctions were far worse. Mila's black-and-white jacket was the most interesting thing about her nighttime look—the rest of it just seemed, well, very H&M. So, in a way, I guess Mila nailed the East Village? Jay's daytime ensemble was at least 3 kinds of hideous: 1. The red and black tank top that looked like an old bathing suit found while dumpster diving 2. Paired with painfully light denim pants 3. That had built-in saddlebags. Yuck. Both Jay and Amy should have gone home. Instead, only Amy was cut so Bunim-Murray Productions could stretch and stretch and stretch the season out until one of the producers dislocates a limb. --A Project Runway without Michael Kors is like a day without technicolor orange glow. --"Sometimes I need a little dose of silly." Saying the word "silly" is the first step, Maya. --"Let's shop at the Studio Secrets wall." Oh, you go right ahead, Collier Strong. I'll be over here. --Anthony and Maya didn't want to be too literal in their Chinatown look. They just wanted to literally make dragon streamers out of fabric and sew them onto a cocktail dress.
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|The water temps are hovering around 74 barring any cold fronts. You can tell things are rough when even guides I am friendly with on land get grumpy on the Water. Perhaps a kind of road rage. I got a verbal dress down from a very easy going guide for navigating through a lake I had no idea was a laid up tarpon area. Well nowI know! I saw one fish today that was laid up and gave me 3 shots before easing away and down the bank. Friday and Saturday the wind is supposed to lay down. In this months Midcurrent Andy Mill pissed off a lot of locals down here by giving up too much information on fishing worm flies. I'm glad he did not post a pic of the fly. I am going to change up my plan tomorrow and get out before sunup to see if I can find some sunrise rollers out in that lake I mentioned earlier. terrible way to learn a new spot but every downside has an upside. If I do hook up there I certainly will have earned it. Bill I had one miss a grab last week too, maybe the same dummy...lol| I hope you guys coming down get in touch when you are here.
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while remembering where I've stood this year. In no particular order. I stood next to the bed of a friend who lay dying, angry at the end for always coming, but angry only for me, relieved for her that it was almost done. I stood next to a friend twirling in wedding gowns, choosing the perfect one to spin her into a new chapter in her life, watching the laughter in her eyes, the flush on her cheeks. I stood in a bookstore with a magazine in my hand, a magazine in which I'd been published, and I wanted to dance like I was 9, I wanted to open it and show everyone near me and say me, me, see? I stood in my kitchen and cried from exhaustion, working on paintings for a show I dearly wanted, then I stood at that show and thought that no doubt it looked so easy to everyone there. I stood in my own shadow while Unravelling and reached for the sky, and the sky reached back. I stood every week at the veterinarian's office, cat in carrier, money in hand, a small price to pay for continued companionship. I stood in my neighborhood, in flowers dropped from trees in the spring, tiny white catawba blossoms, pink blooms from tulip trees, lavender wisteria; in the summer I stood in bare feet on fallen crepe myrtle blossoms of all colors and in the fall I stood ankle deep in golden ginkgo leaves. I stood outside dancing on a hot July 4th night and I stood outside on Christmas Eve afternoon surrounded by whirling snowflakes. I stood in green suede ballerina flats for the opening of a 2nd art show, a name tag on my shirt declaring me Artist. I stood under trees filled with owls and I stood under trees watching hawks. I stood at a school event, hand on my heart for the National Anthem, and watched those across from me refuse to stand and I felt a chill, a shiver down my spine. I stood under umbrellas through a neverending rainy autumn and I stood in the rain when umbrellas lay forgotten behind locked doors. I stood in flipflops, in shoes sewn of polka dots, in boots, in worn out Keds and tattered flats, in high heels that hurt if I wore hose, in high heels that didn't if I didn't. I stood under full moons and high noons, behind white rabbits and under Katie's blue lights, in showers and in front of mirrors and on two politically incorrect feet. I stood on my own and I leaned on friends. I stood in new places, on unfamiliar ground, and in a place called home. I stood in the beginnings of dreams and on red brick roads hot from the sun. I stood in places not of my choosing and I stood with fear, with loss, with my hands over my face hiding the tears. But I stood. The new year comes bearing gifts. Let us open them together and see what we will see.
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Abstract: Human immunodeficiency virus-1 (HIV-1) dynamics reflect an intricate balance within the viruses’ host. The virus relies on host replication factors, but must escape or counter its host’s antiviral restriction factors. The interaction between the HIV-1 protein Vif and many cellular restriction factors from the APOBEC3 protein family is a prominent example of this evolutionary arms race. The viral infectivity factor (Vif) protein largely neutralizes APOBEC3 proteins, which can induce in vivo hypermutations in HIV-1 to the extent of lethal mutagenesis, and ensures the production of viable virus particles. HIV-1 also uses the APOBEC3-Vif interaction to modulate its own mutation rate in harsh or variable environments, and it is a model of adaptation in a coevolutionary setting. Both experimental evidence and the substantiation of the underlying dynamics through coevolutionary models are presented as complementary views of a coevolutionary arms race. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Export to BibTeX MDPI and ACS Style Münk, C.; Jensen, B.-E.O.; Zielonka, J.; Häussinger, D.; Kamp, C. Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein. Viruses 2012, 4, 3132-3161. Münk C, Jensen B-EO, Zielonka J, Häussinger D, Kamp C. Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein. Viruses. 2012; 4(11):3132-3161. Münk, Carsten; Jensen, Björn-Erik O.; Zielonka, Jörg; Häussinger, Dieter; Kamp, Christel. 2012. "Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein." Viruses 4, no. 11: 3132-3161.
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List of Accepted Papers Below are lists of the accepted papers to STOC09. These are preliminary and subject to change. Final camera-ready versions of papers are due Thurs, March 19, 2009 at 9:00am Eastern Time. Instructions for preparation and submission of final versions can be found at Please address any questions to Lisa Tolles at Sheridan Printing.
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Good start buddy! Definently keep at it and sculpt sculpt and more sculpting! Will keep an eye on your progress Looking forward seeing more from you, 3 Hour sketch. nice work on the 3 hour sculpt - keep it going and have fun sculpting, sculpting and more sculpting =) Don't know why but the last pic reminds me of Christopher Walken! A few changes on the monkey. I think is time to move to a full body character.
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MCROBERTS-L ArchivesArchiver > MCROBERTS > 2003-08 > 1061382193 From: Collingwood Keith OBP <> Subject: RE: Samuel McRoberts Sr. Date: Wed, 20 Aug 2003 08:23:13 -0400 Thank you for your information on Sir Alexander and Lady MacRobert (no "s"). I hate to disappoint you but I doubt that there is a connection. If so, I would love to share information with you. If there is a connection it would probably be with Sir Alexander's GG Grandfather John McRobert who moved to Drumblade, Aberdeenshire around 1700 his daughter was born 1709). His grandfather is my GGG Grandfather. He was born in Tarland, Aberdeenshire, Scotland. His father John moved from Drumblade, Aberdeenshire when the landowners starting kicking the croft farmers off the land. John went to Tarland, his brother William and 2 sisters went to Banffshire (no issue), 3 brothers went to Australia (1 with issue), and 1 went to Kent, England (8 children, most of which went to Massachusetts or Onterio, only 1 male had issue, in Massachusetts). I have been working on tracking all of the McRoberts from Sir Alexander's GG Grandfather to present and I did not find anyone named Samuel. On Lady MacRobert (they added the "a" in Mac), I have quite a bit of info as my grandfather corresponded with Lady MacRobert for several years after seeing the article in Life magazine in [June?] 1941. Sir Alexander had 3 sons. Alasdair died in a plane crash at Luton Aerodrome in 1938, Roderick died while attacking an aerodrome in Iraq (Mosul?), in 1940 and youngest brother Ian was missing in action 1 month later while on patrol over the North Sea. Lady MacRobert donated the funds for 4 fighters, 1 for each son and another for the Soviet Union. She also donated the Bomber which was named "MacRobert's Reply." Ironically I am related to Sir Alexander through my mother, and Lady MacRobert (nee Rachael Workman, Worchester, Mass.) through my father. I wish you luck in your searches. I hope that my information is helpful. From: Amanda McRoberts-Valencia [mailto:] Sent: Tuesday, August 19, 2003 11:40 AM Subject: Samuel McRoberts Sr. Some interesting information that may lead us to the origins on Samuel A message board says... There is a McRoberts building at Stirling University, Scotland. Lord McRoberts made a fortune from the East India company and was a great benefactor and the building was financed by his widow as a memorial. Amongst the tunes written by Willy Ross, one of the greats names in Scottish piping, is a lament "The Flight of the Eaglets (McRobert's Lament)", written for Lady McRoberts on the death of her two sons who were Royal Air Force pilots. Another website says... Throughout the history of the Kinloss Royal Air Force station, the development of community relations has always been extremely important. Every year an open day was held to which local dignitaries and members of the local community were invited . One frequent visitor was Lady McRoberts, whose four sons were all killed in action with the RAF during the war, such was her loyalty to the service that she bought a complete Lancaster Bomber, known as 'McRoberts' Revenge' in their memory. During WWII my Grandfather said there was a cover story on Lady McRoberts donating this airplane. Now I have looked for it a couple times at flee market and have never been able to find it but the above information is interesting. Now, even more interesting is the fact that a McRoberts researcher told me that he has a piece of documentation (which I have never received) stating that Samuel McRoberts Sr. came from Fincastle Glen Scotland. Now looking up the location of Fincastle Glen it is about 30 miles from Stirling University using Perth and Kinross as a guide. See this Now that is a lot of lines to connect without the proper documentation but I am on my way out to Fincastle on Monday, August 25th and I will return on the 27th so hopefully I can find the above mentioned documentation that he came from Fincastle. Having other McRoberts in the area makes me lean towards this area as one to pay special attention to in looking for Samuel McRoberts' roots. I hired a researcher in Scotland and they sent me Historic maps of Glen Fincastle. We will see where this leads us! I welcome any and all input!
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Kings open training camp on Saturday The Sacramento Kings just announced their training camp schedule for the 2011-12 campaign. The teams practice facility doors open at noon on Saturday, December 10th for day one of camp. On Thursday, December 15th, the Kings hold their official media day, followed by their annual Kings-on-Kings open scrimmage at 7pm. Camp breaks on December 16th, the day before the Kings open their two game pre-season schedule (@GS 12/17 and @PBP 12/20) with the Golden State Warriors. Follow us here at Cowbell Kingdom as we give you in-depth coverage, daily updates and all exclusive interviews you can handle.
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From the Times Ledger: As a Whitestone civic group fights to turn an overgrown, empty lot into a community sports complex, one resident’s innocuous post on Facebook has spawned a well-documented and surprisingly candid discussion into opinions on both sides of the fence. The Malba Gardens Civic Association has been toying with the idea of building baseball, soccer and running facilities on the vacant, 6-acre lot along 150th Street for years, according to the civic’s president, Alfred Centola. “My idea is to reacquire the land and give it back to the kids of the community,” he said of the lot, between 3rd and 6th avenues, which was previously owned by the Catholic Youth Organization. The quest was laid out in an October Daily News opinion piece written by Centola, and it all seemed like a good idea to Steve Behar, who posted “Nice Op-Ed. My brother and I went to that CYO camp” at 5:56 p.m. Oct. 5 on Centola’s Facebook page. Twelve minutes later, City Councilman Dan Halloran (R-Whitestone) replied: “Steve — and who’s going to come up with the tens of millions to acquire, remediate, develop, build, and staff this facility?” Halloran often tempered his responses with phrases like “guess you didn’t know that” or “you have no clue how discretionary spending works.” Centola at one point referred to the councilman as “testy” and said “try and relax yourself, you might give yourself a heart attack.” Well, at least he didn't drop the F-bomb repeatedly this time.
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In which Scrabble dictionary does MARLED exist? Definitions of MARLED in dictionaries: to fertilize with marl (an earthy deposit containing lime, clay, and sand) There are 6 letters in MARLED: A D E L M R Scrabble words that can be created with an extra letter added to MARLED All anagrams that could be made from letters of word MARLED plus a Scrabble words that can be created with letters from word MARLED 6 letter words 5 letter words 4 letter words 3 letter words 2 letter words Images for MARLED SCRABBLE is the registered trademark of Hasbro and J.W. Spear & Sons Limited. Our scrabble word finder and scrabble cheat word builder is not associated with the Scrabble brand - we merely provide help for players of the official Scrabble game. All intellectual property rights to the game are owned by respective owners in the U.S.A and Canada and the rest of the world. Anagrammer.com is not affiliated with Scrabble. This site is an educational tool and resource for Scrabble & Words With Friends players.
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Nanotechnology is a relatively new sector, and future growth is dependent largely on growing government support and heavy investments in R+D initiatives. Nanotechnology plays a central role is the development of desktop manufacturing, cellular repair, artificial intelligence, inexpensive space travel, clean + abundant energy, and environmental restoration. Global nanotechnology market is increasingly witnessing a move towards consolidation, as players reorient strategies and realign their businesses to better reflect the changing competitive dynamics, and remain viable and competitive in the maturing market. Micro-electro-mechanical systems (MEMS), and Microsystems Technology (MST) represent rapidly evolving niche technology areas with considerable potential. The field is gradually transforming from being 'technology-driven' to 'application-driven'. Banking on the 'top-down' technology, both the concepts grew on the microelectronics technologies. Significant applications are in communication, industrial, medical, chemical and automotive industries. Nanotechnology is an attempt by science to manipulate the world at its intimate level. A notion that matters can be dealt at the levels of atoms and molecules led to the invention of instruments such as Atomic Force Microscopes (ATM), Scanning Tunneling Microscope (STM), and Near Field Microscope. Chemicals and Advanced Materials are projected to emerge as the largest and rapidly emerging application area for nanotechnology. Other key application areas include transportation industry, health and life science industries, electronics and communications, research, energy, consumer products, and tools. Manufacturing processes continue to emerge using nanotechnology, leading to cost reductions and increasing new applications for the technology. A wide range of new applications from sporting goods to fuel catalysts, contribute for the growth of nanomaterials market. In the food-packaging area, nanomaterials are currently being developed with improved thermal and mechanical properties to ensure better food protection. Nanotubes is the most promising nanotech product category with numerous potential applications. Nanotubes are touted as plausible replacements for silicon in integrated circuits. Nanotubes exhibit exceptional thermal, mechanical, and electrical properties. These are primarily used in the production of plastic-based equipment for semiconductor wafers, mechanical memory (RAM), and computer disk drives. The improvements exhibited by the introduction of carbon fibers are likely to be dwarfed by the evolution of nanotubes. Nanotubes exhibit tremendous tensile strength that is finding numerous applications in the aerospace, automobiles and construction industries. The potential for nanotubes market is enormous in the delivery of medicine, manufacturing of computer circuitry, and heat reflective The report titled "Nanotechnology: A Global Outlook Series", published by Global Industry Analysts Inc, provides a collection of statistical anecdotes, market briefs, and concise summaries of research findings. The report offers a bird's eye view of this new, promising, and pulsating, potential laden industry. The report provides a rudimentary insight into the concept of nanotechnology, providing selective insights into major technology trends, and its impact on commercial applications in key end-use industries. Annotated with 20 market data-rich tables enumerating key research findings, the global and regional level of discussion culminates to provide a macro-level perception of the industry in its totality. Also included is an indexed, easy-to-refer, fact-finder directory listing the addresses, and contact details of 1,049 companies worldwide. For more details about this research report, please visit
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Shots fired from a car riddled another car with bullets Wednesday night in Seattle. Police say one bullet grazed a teenager in the head. Two other teens in the car were hurt with it crashed. KOMO reports police are looking for an SUV from which the shots were fired, but investigators don't have a good description. At least five bullets hit the teens' car. Police say the teens don't know, or aren't saying why, they were targeted.
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[Show abstract][Hide abstract] ABSTRACT: Upon the transition of dark-adapted plants to low light, the energy-dependent quenching (qE) of excitation energy is only transiently induced due to the only transient generation of the transthylakoid pH gradient. We investigated the transient qE (qE(TR)) in different Arabidopsis (Arabidopsis thaliana) mutants. In dark-adapted plants, qE(TR) was absent in the npq4 mutant (deficient in the PsbS protein) and the pgr1 mutant (restricted in lumen acidification). In comparison with wild-type plants, qE(TR) was reduced in the zeaxanthin (Zx)-deficient npq1 mutant and increased in the Zx-accumulating npq2 mutant. After preillumination of plants (to allow the synthesis of large amounts of Zx), the formation and relaxation of qE(TR) was accelerated in all plants (except for npq4) in comparison with the respective dark-adapted plants. The extent of qE(TR), however, was unchanged in npq1 and npq4, decreased in npq2, but increased in wild-type and pgr1 plants. Even in presence of high levels of Zx, qE(TR) in pgr1 mutants was still lower than that in wild-type plants. In the presence of the uncoupler nigericin, qE(TR) was completely abolished in all genotypes. Thus, the transient qE(TR) shows essentially the same characteristics as the steady-state qE; it is strictly dependent on the PsbS protein and a low lumen pH, but the extent of qE(TR) is largely modulated by Zx. These results indicate that qE(TR) does not represent a different quenching mechanism in comparison with the steady-state qE, but simply reflects the response of qE to the dynamics of the lumen pH during light activation of photosynthesis. [Show abstract][Hide abstract] ABSTRACT: To evaluate the role of specific xanthophylls in light utilization, wild-type and xanthophyll mutant plants (npq1, npq2, lut2, lut2npq1 and lut2npq2) from Arabidopsis thaliana were grown under three different light regimes: 30 (low light, LL), 150 (medium light, ML) and 450 (high light, HL) mumol photons m(-2) s(-1). We studied the pigment content, growth rate, xanthophyll cycle activity, chlorophyll fluorescence parameters and the response to photoinhibition. All genotypes differed strongly in the growth rates and the resistance against photoinhibition. In particular, replacement of lutein (Lut) by violaxanthin (Vx) in the lut2npq1 mutant did not affect the growth at non-saturating light intensities (LL and ML), but led to a pronounced reduction of growth under HL conditions, indicating an important photoprotective role of Lut. This was further supported by a much higher sensitivity of all Lut-deficient plants to photoinhibition in comparison with the wild type. In contrast, replacement of Lut by zeaxanthin (Zx) in lut2npq2 led to a pronounced reduction of growth under all light regimes, most likely related to the permanent non-photochemical dissipation of excitation energy by Zx at Vx-binding sites and the destabilization of antenna proteins by binding of Zx to Lut-binding sites. The high susceptibility of lut2npq2 to photoinhibition in comparison with npq2 further indicated that the photoprotective function of Zx is abolished in the absence of Lut. Thus, it can be concluded from our work that neither Vx nor Zx is able to fulfil the essential photoprotective function at Lut-binding sites under in vivo conditions. [Show abstract][Hide abstract] ABSTRACT: Arabidopsis thaliana plants grown from ethyl methane sulfonate-treated seeds were screened for so-called que mutants, which are affected in non-photochemical energy quenching. Based on video imaging of chlorophyll fluorescence an energy dissipation mutant, que1, was identified, isolated and characterized. Similar to the npq mutants, the que1 mutant showed a drastically reduced capacity for pH-dependent energy dissipation, qE, but without affecting the Delta pH-dependent conformational changes at 535 nm (DeltaA (535)), which have been supposed to be obligatorily correlated with qE and to reflect pH-regulated binding of zeaxanthin to the PsbS protein. Western blot and DNA sequence analysis revealed that neither a reduced expression of the PsbS protein nor a mutation in the PsbS gene was responsible for the missing qE in que1. Measurements of 9-aminoacridine fluorescence quenching showed that the acidification of the thylakoid lumen was also not affected in the mutant. Furthermore, que1 was able to convert violaxanthin to zeaxanthin. However, unusual characteristics of zeaxanthin formation in the mutant pointed at an altered availability of violaxanthin for de-epoxidation. This was further accompanied by a decrease of the photochemical quenching of chlorophyll fluorescence (qP), an increase of the portion of oxidized P700 and a reduction of the electron transport rate. These characteristics indicate changes in the organization of the thylakoid membrane that affect linear electron transport (but not lumen acidification) and the formation of energy dissipation in photosystem II. Preliminary genetic analysis revealed that the phenotype of que1 is related to two different mutations, mapped to the lower arms of chromosomes 1 and 4.
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Student Jacob Langenhan addresses a question to the Democratic candidates during a mock political convention organized by Kids Voting USA in March 2012 at the University of Wisconsin Marathon County in Wausau. The majority of local teens believe that voting is important and that people's votes really matter, according to a survey conducted last month by Kids Voting USA-WI/Marathon County. The organization, which works to help prepare and excite young people for civic engagement, surveyed more than 2,400 high school students in the Wausau School District. Kids Voting intends to use this first survey to establish a baseline for comparison of high school students' attitudes toward civic participation over time. ? 63 percent disagreed or strongly disagreed with the statement "I don't think people's votes really matter." ? 41 percent strongly disagreed or disagreed with the statement "People like me don't have any say about what the government does." ? 45 percent say they talk about issues with others; 55 percent say they seldom or never discuss political issues.
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Elaine Ayala comments on Latino news, cultura y más. Posts filtered on Tag Sandra Cisneros constructs an altar to her parents at a Day of the Dead exhibit at the National Museum of Mexican Art in Chicago, where they lived. [Read More] San Antonio artist Alex Rubio’s calavera print a part of National Museum of Mexican Art’s Dia de los Muertos show. [Read More]
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Leslie Wade MILLER, Plaintiff and Appellant v. Jenny Lynn MILLER, n/k/a Jenny Sailer, Defendant and Appellee. [¶ 1] Leslie Wade Miller appeals from an order denying without an evidentiary hearing his motion to change the primary residential responsibility for his son, B.P.M., from Jenny Lynn Miller, now known as Jenny Sailer, to himself. We affirm, concluding the district court did not err in ruling Miller failed to establish a prima facie case justifying a change of primary residential responsibility. [¶ 2] Miller and Sailer were divorced in 2003. Under the parties' agreement, Sailer was granted primary residential responsibility for the couple's two children and Miller was granted parenting time. In 2007 Miller brought a motion to change the primary residential responsibility for B.P.M., the oldest child. Miller alleged that B.P.M., “a special needs child,” was not happy living with Sailer and that Sailer had improperly taken B.P.M. off medication, removed him from special education classes, moved several times, and lived with a boyfriend. The district court denied the motion, concluding Miller had not established a prima facie case to require an evidentiary hearing. [¶ 3] In March 2012, Miller again moved to change primary residential responsibility for B.P.M., who was then 15 years old and an eighth-grade student. In support of the motion, Miller presented his affidavit, B.P.M.'s affidavit, and several of B.P.M.'s report cards. Many allegations mirrored those made in support of the 2007 motion. Miller also alleged Sailer had arguments with B.P.M., had contacted law enforcement about his behavior, and had taken him to juvenile youth services and threatened to send him to Dakota Boys Ranch. Miller alleged Sailer interfered with his relationship with B.P.M., did not provide for B.P.M.'s needs, and B.P.M.'s poor school performance improved during a two-month period he lived with Miller. B.P.M. alleged he argued with Sailer and stated he preferred to live with Miller. In response to the motion, Sailer presented her affidavit and several of B.P.M.'s class grade reports. Sailer provided details to counter or explain the allegations made against her and objected to hearsay statements contained in the documents filed by Miller. [¶ 4] The district court denied Miller's motion without holding an evidentiary hearing, concluding the affidavits and other evidence presented in support of the motion did not establish a prima facie case justifying a change of primary residential responsibility. The court interpreted the “central theme” of the motion to be “that B .P.M., now age 15, does not agree with some of the restrictions and requirements Jenny imposes upon him, and that B.P.M. has stated a preference to live with Leslie.” The court concluded “the conduct identified in the opposing affidavits suggests that he is not of sufficient maturity for the Court to give substantial weight to his preference.” [¶ 5] Miller argues the district court erred in ruling he failed to establish a prima facie case to support a change of primary residential responsibility. [¶ 6] Under N.D.C.C. § 14–09–06.6(6), a court may modify primary residential responsibility after a two-year period following the date of entry of an order establishing primary residential responsibility if the court finds “[o]n the basis of facts that have arisen since the prior order or which were unknown to the court at the time of the prior order, a material change has occurred in the circumstances of the child or the parties,” and the “modification is necessary to serve the best interest of the child.” A motion must be denied without an evidentiary hearing “unless the court finds the moving party has established a prima facie case justifying a modification.” N.D.C.C. § 14–09–06.6(4). In Thompson v. Thompson, 2012 ND 15, ¶ 6, 809 N.W.2d 331, this Court said: Whether the moving party established a prima facie case is a question of law, which is reviewed de novo on appeal. Wolt v. Wolt, 2011 ND 170, ¶ 9, 803 N.W.2d 534. The moving party has the burden to establish a prima facie case justifying modification. Ehli v. Joyce, 2010 ND 199, ¶ 7, 789 N.W.2d 560. This Court has said: A prima facie case is a bare minimum and requires facts which, if proved at an evidentiary hearing, would support a change of custody that could be affirmed if appealed. When determining whether a prima facie case has been established, a court may not weigh conflicting allegations in affidavits. However, allegations alone do not establish a prima facie case, affidavits must include competent information, which usually requires the affiant to have first-hand knowledge, and witnesses are generally not competent to testify to suspected facts. Affidavits are not competent if they fail to show a basis for actual personal knowledge, or if they state conclusions without the support of evidentiary facts. Id. (citations omitted). A material change in circumstances is an important new fact that was unknown at the time of the prior custody decision. Id. at ¶ 8. A material change in circumstances may exist when there has been an attempt to alienate a child's affection for a parent or when there has been a frustration of visitation. Id. A significant change in the actual arrangement for primary residential responsibility from the arrangement contemplated by the prior order may also be a material change in circumstances. See id. at ¶ 10. A mature child's reasonable preference to live with a particular parent may constitute a material change in circumstances to justify a change in primary residential responsibility if there are persuasive reasons for that preference. See, e.g., Frison v. Ohlhauser, 2012 ND 35, ¶ 7, 812 N.W.2d 445; Lechler v. Lechler, 2010 ND 158, ¶ 11, 786 N.W.2d 733. [¶ 7] Some of the hearsay in Miller's affidavit relates to his allegations about Sailer taking B.P.M. off of medications, Sailer's living arrangements, and Sailer's educational choices for B.P.M. These allegations were also contained in an affidavit filed in Miller's unsuccessful 2007 attempt to change the primary residential responsibility for B.P.M. “ ‘Under res judicata principles, it is inappropriate to rehash issues which were tried or could have been tried by the court in prior proceedings.’ “ Laib v. Laib, 2010 ND 62, ¶ 10, 780 N.W.2d 660 (quoting Wetch v. Wetch, 539 N.W.2d 309, 311 (N.D.1995)). Consequently, Miller's allegations raised and rejected by the district court in 2007 cannot serve as a basis to support his motion to change the primary residential responsibility for B.P.M. in these proceedings. [¶ 8] Miller contends a de facto change of primary residential responsibility occurred when, with Sailer's consent, B.P.M. lived with him for a two-month period from October 2011 until December 2011. Although a “significant change in the actual arrangement for primary residential responsibility from the arrangement contemplated by the prior order may also be a material change in circumstances,” Thompson, 2012 ND 15, ¶ 6, 809 N.W.2d 331, N.D.C.C. § 14–09–06 .6(3)(c) suggests that a de facto change in primary residential responsibility cannot occur unless the “primary residential responsibility for the child has changed to the other parent for longer than six months.” The two-month period alleged here is insufficient as a matter of law. Cf. Ehli v. Joyce, 2010 ND 199, ¶¶ 2, 10, 789 N.W.2d 560 (where judgment allowed parties to share time equally with child, party's allegation that she actually had child 95 percent of the time raised a prima facie case that there was more than a minor variance from the initial judgment). [¶ 9] Miller argues that his life has “improved” while Sailer's life has “declined,” and Sailer has failed to provide for B.P.M.'s needs. In his affidavit, Miller asserted “[m]y life has improved greatly” and “I have a more steady job,” while “Jenny's life has declined, particularly in regards to her relationship with BPM” because “they argue constantly.” B.P.M. in his affidavit complained that “my mom and I argued all the time.” Miller further asserted “I have always had to provide boots and clothing throughout the years and when BPM came to live with me I had to buy him new everything ․ because he came with the clothes on his back.” Miller's assertion about the improvements in his life is a conclusory allegation, see, e.g., Sweeney v. Kirby, 2013 ND 9, ¶ 5, 826 N.W.2d 330, and in any event would not by itself be sufficient to show a significant change in circumstances. See, e.g., Interest of Thompson, 2003 ND 61, ¶ 7, 659 N.W.2d 864. Furthermore, arguments between teenagers and their parents are common and are to be anticipated in the normal course of parenting. The alleged arguments between B.P.M. and Sailer cannot be considered a material change in circumstances. Miller's allegation that Sailer does not send, or B.P.M. does not bring, enough clothing when Miller exercises parenting time does not indicate a failure on the part of Sailer to provide for B.P.M.'s needs in Sailer's home. [¶ 10] Miller argues Sailer is a detriment to B.P.M.'s physical or emotional health or development because “Jenny called the cops,” she “took him to the Dickinson Juvenile Youth Program,” and she “has threatened to send him to Dakota Boy's Ranch.” A parent responsible for a child's care and supervision may discipline the child and may use reasonable force to do so. See, e.g., Rudnick v. Rode, 2012 ND 167, ¶ 23, 820 N.W.2d 371. Sailer's attempts to discipline B.P.M. through legal means do not raise a prima facie case that she is a detriment to his physical or emotional health or development. [¶ 11] Miller argues Sailer is a detriment to B.P.M.'s education and development because B.P.M. began “doing much better” in school during the two-month period he lived with Miller. B.P.M. agreed that “[s]chool got a lot better and I did better when I lived with my dad.” However, B.P.M.'s report cards submitted by Miller do not indicate any marked improvement in B.P.M.'s school performance during this period of time. The party opposing a motion to change primary residential responsibility can rebut a prima facie case by presenting evidence that conclusively shows the allegations of the moving party have no credibility or are, on their face, insufficient to justify modification. Wolt v. Wolt, 2011 ND 170, ¶ 9, 803 N.W.2d 534. Individual class grade reports submitted by Sailer establish that there was no particular pattern to B.P.M.'s class grades, which ranged from As to Fs before, during and after B.P.M. stayed with Miller. Rather, the only consistency in B.P.M.'s grades is their random inconsistency. Miller's argument is without merit. [¶ 12] Miller argues the district court erred in not giving substantial weight to B.P.M.'s preference to live with him, and at the very least, erred in failing to hold a hearing to determine if B .P.M. was sufficiently mature to express a preference. We agree that, as children mature, more weight should be given to their preferences if there are persuasive reasons for their preferences. See Volz v. Peterson, 2003 ND 139, ¶ 11, 667 N.W.2d 637; Kelly v. Kelly, 2002 ND 37, ¶ 32, 640 N.W.2d 38. However, the evidence submitted in this case does not permit an inference that B.P.M. is a mature child. First, B.P.M.'s school grades demonstrate that although he is capable of receiving As in his school work, he most often receives Ds and Fs. The grade history reflects that as a teenager B.P.M. is making choices about his school performance that reflect a lack of maturity. [¶ 13] Second, Miller relies on B.P.M.'s affidavit in which B.P .M. states: 1. I have wanted to live with my dad for many, many years. Anytime I asked to stay with dad more the answer was always no. When I would ask why, mom would say, because. 5. I do not want to live with my mom. I want to live with my dad. Living with my dad was less stressful and made it easier to cope at school. When I lived with dad the only thing I worried about every day was going back to my moms [sic]. At mom's I don't ever get the things ever that I want or ask for and mom always says you'll get what I decide. We agree with the district court that the reason for B.P.M.'s preference is he “does not agree with some of the restrictions and requirements Jenny imposes upon him.” This is not a persuasive reason for a child's preference to live with the other parent. The court appears to have improperly relied on the whole content of Sailer's affidavit to determine B.P.M. was not sufficiently mature to give weight to his preference because a court may not weigh conflicting allegations in affidavits. See Thompson, 2012 ND 15, ¶ 6, 809 N.W.2d 331. But reliance on Sailer's affidavit was unnecessary. The evidence presented by Miller shows B.P.M. is immature and has no persuasive reason for his preference to live with Miller. The court was not required to hold a hearing to determine B.P.M.'s maturity. [¶ 14] It is unnecessary to address other arguments raised because they are without merit or are unnecessary to the decision. Miller's allegations, if proved at an evidentiary hearing, would not support a change of primary residential responsibility. We conclude the district court did not err in ruling Miller failed to establish a prima facie case justifying a change of primary residential responsibility. [¶ 15] The order is affirmed. [¶ 16] GERALD W. VANDE WALLE, C.J., MARY MUEHLEN MARING, DANIEL J. CROTHERS, and DALE V. SANDSTROM, JJ., concur.
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Women and Religion Leadership of religious organizations has been for hundreds of years dominated by males. However, it has always been known, if not acknowledged, that much religious work as well as support of the institutional church has been done by women. Only within the recent decades have women been admitted into the leadership of many religious groups. In others, their access to clergy and other leadership roles is still being contested. It is only recently, too, that women's contributions to the history of faith communities has become a topic research. This section contains articles and research reports on the topic of women in religion. A listing of links to other academics sites on women and religion is also included.
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CC-MAIN-2015-06
http://hirr.hartsem.edu/research/women_religion.html
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Nissan has officially cranked out 1 million of the company's Frontier pickup trucks. By the time the first truck to bear the Frontier name rolled off of the line in 1997 as a 1998 model, Nissan had already established itself as a purveyor of fiendishly tough, inexpensive midsized pickups. According to PickupTrucks.com, the Japanese automaker first got into the American truck market back in 1959 when the Datsun 1000 landed on our shores. But it wasn't until the Datsun 520 showed up six years later that sales began to really take off. Nissan became the first Japanese automaker to manufacture pickups in the U.S. in 1983 when the company began producing vehicles at its Smyrna, Tennessee plant. The move avoided a 25-percent tariff on foreign-built pickups, and since then, Nissan has built more than 2 million small trucks at the facility. PickupTrucks.com reports that Nissan is working hard at the next-generation Frontier, but the model is facing poor sales at the moment. Last year, the automaker managed to sell just under 40,500 units – less than half of the 100,000 Hardbody pickups Nissan sold in 1987. Head over to PickupTrucks.com for an excellent rundown of the history of Nissan trucks in America.
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http://www.autoblog.com/2011/06/08/nissan-frontier-hits-1-000-000-units/
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Retirees in the Howard County Public School System will be able to stay under their old Medicare insurance plans, after the Board of Education unanimously voted Tuesday to suspend the implementation of the United Healthcare Medicare Advantage plan for one year. The new insurance was set to take effect Jan. 1, 2014 for Medicare-eligible retirees, but concerns were raised that United Healthcare was not accepted at local medical systems like Howard County General Hospital, Johns Hopkins Hospital or University of Maryland Medical Center. “Very late last week we made the decision, because there were so many concerns, that pending providers’ acceptance of the plan it would be best to suspend the implementation,” said Katrina Burton, the school system’s executive director of business and finance. According to a letter sent to retirees on Friday, Dec. 13 from school officials, retirees will be able to stay on their existing Medicare plan from either Aetna or Care First for 2014. Medical premiums will not increase during that year. There will be a special enrollment period for impacted retirees from Jan. 21, 2014 to Feb. 7, 2014. The United Healthcare plan, pending a review, validation and approval of medical providers and a resolution to other concerns expressed by retirees, will go into effect Jan. 1, 2015 “if it’s viable,” Burton said.Copyright © 2015, The Baltimore Sun
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http://www.baltimoresun.com/news/maryland/howard/ellicott-city/ph-retiree-healthcare-20131218-story.html
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Professor Anantharaman joined Rutgers Business School in the Fall of 2009, after having received her Ph.D. in Business Administration with a concentration in Accounting from Columbia University’s Graduate School of Business. She is the Robert J. Boutillier Endowed Faculty Scholar in Accounting. She teaches Introduction to Managerial Accounting at the undergraduate level in the Newark campus. She is interested in disclosure and corporate governance issues, with a specific focus on financial institutions and pension funds. Prior to joining Columbia University as a student, she worked as a financial controller in India and Botswana. Please visit Professor Anantharaman's website to view her CV.
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its going down... yeah, I said it the weights is goign down.. i weighed in this morning, and it was 222.5 from 224! In like 4 days!! Yeah !! I went to the gym for a couple of hours, burned 350 calories on the treadmill, then did weights an... Read more
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Mark Zuckerberg - This person was a sophomore and a computer major at Harvard University when he met a senior with whom he would eventually founded Facebook. Eduardo Saverin - This person was born in Brazil to a wealthy family and was raised in Miami. Sean Parker - As a high school student, this person created the web site Napster that allowed users to download music free. Winklevoss Twins - These people were Harvard seniors and were bound for the Olympics in the two-man rowing competition when they recruited someone to do the programming for their partially developed social networking site. Divya Narendra - This person was a partner in a website being developed and recommended another person as a possible programmer for their social networking site. Jeff Thiel - This person was the creator of the popular Internet company, PayPal. He was the first big investor... This section contains 287 words (approx. 1 page at 300 words per page)
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The Zero Energy House project was proposed by Dan Smith to demonstrate the concept of “build tight and ventilate right.” Smith led the design and production of the home with the help of the Architectural Engineering Design, Interior Design, Landscape Management and Automotive Restoration programs. Smith serves as CPTC’s Sustainable Building Science instructor and has led his students in completing the project over the past three years. The Zero Energy House is located on Clover Park Technical College's Lakewood campus, near Steilacoom Blvd. The ZEH features passive heating qualities incorporated into the design. The vaulted ceiling over the great room features a south-facing wall of operable awning windows. This provides natural day light and takes advantage of prevailing winds and passive air movement. The home’s energy production and consumption are tracked to verify zero energy consumption. The home is part of a larger commitment to sustainability at CPTC. The College established a Sustainability Committee in the Spring of 2010 to pursue efficiency, energy consciousness and green initiatives. The committee has championed paper reduction efforts, recycling and composting, and an energy conservation goal to lower electricity costs on campus. In addition, the College has leveraged two energy efficiency grants to strategically invest in upgraded lighting, motion sensor installation and heating, ventilation and air conditioning upgrades. The project will bring to life program concepts taught in class and provide an example of simple changes that can add up to a big difference in the performance characteristics of a home. The house will also be used as a working laboratory for students to learn about air leakage concepts and training on air leakage testing equipment. Energy production and consumption will be tracked to verify that the house is in fact achieving zero energy consumption. Sufficient technology will measure the individual circuits of the system to experiment with the consumption of different plug loads and appliances. Passive heating qualities include the amount of south facing glass and the ideal orientation developed during the design process. Natural ventilation will be the primary source of air conditioning in the building. The vaulted ceiling over the great room will feature a wall of south facing operable awning windows providing natural day light and will take advantage of prevailing winds and passive air movement. A golf cart is being restored through the funding for the house. The cart will be recharged by the PV system on the house and used to promote the two programs jointly. On campus project partners include the following programs: Architectural Engineering Design, Interior Design, Landscape Management, and Automotive Restoration.
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If you are thinking of learning Aikido there is no better place to begin than at the New York Aikikai. You will benefit from its straightforward approach to traditional aikido. Your opportunity for personal progress is unlimited because your dues entitle you to unlimited classes throughout the month. Check the class schedule and instruction staff to see how the New York Aikikai offers you the highest level instruction, 7 days a week, five times a day. Please don’t let the size and prestige of the New York Aikikai intimidate you. Beginners are always welcome. The dojo also offers special Beginner Classes twice each month, at no additional charge, where aikido fundamentals and basics are taught in a stress-free atmosphere. Please observe a class before joining. No appointment is necessary. You will see that training in Aikido is above all enjoyable and exhilarating. When you visit, feel free to ask the instructor, the dojo staff or members any questions. (see also FAQs). You may sign up for membership at any time (please see “Rates” for details). All you need to start is a gi (practice uniform), available for purchase at the dojo. With a daily schedule that starts at 6:45 AM and ends at 6:45 PM the New York Aikikai will surely have a class that's perfect for you. Visit us soon.
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Feb 23, 2002 IRVINE, Calif. (AP) - Jerry Green scored 29 points, including UC Irvine's last five, as the Anteaters held off a late rally to beat UC Santa Barbara 71-67 on Saturday. After the Gauchos took a 67-66 lead with :50 remaining, Green hit a jumper, drew a foul and sank two free throws to put the Anteaters (20-8, 13-4 Big West) up 70-67. UC Santa Barbara (15-10, 9-7) then missed the potential game-tying shot and Green made one of two free throws to seal the Irvine victory. Mike Hood added 10 points for the Anteaters, who led 37-33 at halftime.
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I've always had a weakness for horror movies. You know, the classic movie monsters from the 1930s and 1940s - Frankenstein, Son of Frankenstein, The Invisible Man, The Mummy, The Wolfman. I'd watch them on late-night television on the one independent channel we got in Indianapolis when I was growing up. Sometimes they'd broadcast Saturday matinees, but the after-midnight versions always seemed better. That first wave of horror films stemmed in most part from concern about science overstepping its boundaries. A mad scientist like the overzealous Dr. Frankenstein or the character Claude Rains played in The Invisible Man went too far in his hunger for knowledge. There were, after all, some things man was not supposed to know. Many fed off anxiety about what was occurring in Germany and Eastern Europe at the time. War clouds were swirling and many of the horror films of the 1930s reflected the gloomy headlines from that region of the world. It is not a coincidence that the settings for Frankenstein, Dracula, The Wolfman and other films of that ilk often were in Germany and Transylvania or based on folk legends from that part of the world. After World War II there was a new wave of horror films in the 1950s that put a more modern spin on things. They focused on mutated insects, sea beasts and other creatures that challenged man for dominance of the world. For the most part, they were a reflection of fears generated by the Atomic Age, triggered by the atomic blasts that ended World War II. They were scary but fun because you knew that, as dangerous as the world had become, there weren't really any giant monsters lurking outside or pods growing in the basement ready to suck out your brains. It Came from Beneath the Sea was the first horror movie I actually saw on the silver screen, and it made a deep and lasting impression. Something - probably nuclear radiation - caused an octopus to grow into a giant that threatened to level San Francisco. Beginning of the End essentially was the same movie but with giant locusts, as were The Monster Who Challenged the World (giant slugs), Creature from the Black Lagoon and, of course, The Fly. Let's not forget the classics Them (about giant ants) The Incredible Shrinking Man, or The Blob. When the effects of radiation weren't the primary evil, it was the prospect of visitors from space, so there was It Came from Outer Space, It! The Terror from Beyond Space, Earth vs. the Flying Saucers, The Thing and Invasion of the Body Snatchers. More often than not, the movies were low-budget affairs offering a few cheap thrills. They also were a reflection of our times; a reaction to our concerns about nuclear power, the rise of communism and fear of the unknown. But something happened in the 1970s - the horror movies took a troubling new direction. I first noticed it with the Friday the 13th series of movies. It also is present in the Halloween movies, as well as Rosemary's Baby, Village of the Damned, Children of the Damned, Scream, Scream 2, Child's Play, The Lost Boys, The Good Son, Near Dawn and too many other movies to mention. The new scary elements are kids, usually teenagers - and all you have to do is look at the headlines today to understand why. Remember the two Arkansas boys who gunned down their classmates earlier this year in a murderous rage? Or any of the other similar shootings involving teenagers that have wound up as front page news? How about the 7- and 8-year-old kids awaiting trial in Chicago for killing a young girl for her bicycle? It can't get any scarier. Forty years ago, when The Blob was threatening moviegoers around the globe, it was a teenaged Steve McQueen who saved the day. It wouldn't happen that way today. Today, on screen and off, kids have replaced mutants and monsters in our psyche as nightmare generators - and unlike the fright movies of the past, these horrors are real. The point couldn't have been made clearer last week with two spine-tingling interviews that appeared the same day in The Lake Sentinel - one with Charity Keesee, girlfriend of vampire cult member Rod Ferrell, and the other with Heather Wendorf. Keesee, the 17-year-old who was sentenced to 101/2 years in prison for her part in the beating deaths of Richard and Ruth Wendorf last year, talked about her continuing affection for Ferrell, who now is on death row. Heather, who skipped off with Ferrell and his vampire cult followers after they killed her parents, never was indicted. Neither seemed particularly moved by the tragic deaths. Both seemed primarily to be sorry for themselves. Keesee said she never believed Ferrell actually would kill the Wendorfs. But never mind, she said she still loved him anyway. For her part, Heather was preoccupied by what she felt was a lack of acceptance in the community after her parents' murders. How dare anyone blame her. ``Poor me!'' they both seemed to be saying, with little understanding or remorse. It was an attitude understandable in, say, 4-year-olds who misbehave on a playground rather than young adults caught up in murder. Both teens are creepy enough to inspire a whole new wave of horror films, but I don't want to see those movies. Horror is only fun when it is make-believe.
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6404-Malone University Chancel Players Now Scheduling 6404-September 13, 2012 The Malone University Department of Church Relations is pleased to announce that members of Chancel Players, Malone's student drama outreach group, are still scheduling for the September 2012 - April 2013 season. To book the Chancel Players, contact Timothy Pitzer, director of church relations, at 330-471-8434, or email him at gcvgmre+znybar+rqh The Malone University Chancel Players, directed by Deanna Dallas, perform faith-based comedy and drama in schools and churches community organizations. The group also performs material appropriate for private as well as public school students. Members of the 2012-2013 Chancel Players are: - Alexis McCullough, a senior art major from Newark - Jared Hoffmeyer, a senior exercise science major from Canton - Hannah Morgan, a sophomore art major from Roots-town - Julian Law, a senior Bible and theology major from Caldwell - Becca Hoffmeyer, a senior biology major from Canton - David Carmany, a sophomore communication arts major from Wellington To book the Chancel Players, contact Timothy Pitzer, director of church relations, at 330-471-8434. Malone University, a Christian university for the arts, sciences, and professions in the liberal arts tradition, affiliated with the Evangelical Friends Church, awards both undergraduate and graduate degrees in more than 100 academic programs. Malone is recognized by the prestigious Templeton Foundation as a leader in character development, named an NAIA Champions of Character Five Star Award winner, and is ranked among the top colleges and universities in the Midwest under the category Regional Universities according to U.S.News & World Report's America's Best Colleges 2012. Suzanne Thomas, APR Director of University Relations 2600 Cleveland Avenue N.W., Canton, OH, 44709
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Explosions reported at New Jersey chemical plant WEST BERLIN TOWNSHIP, N.J. (AP) — A fire and several small explosions have been reported at a chemical manufacturing company in Southern New Jersey. Fire crews are battling a blaze that started around 2 p.m. Thursday at ResinTech, a plant in West Berlin that makes resin. No injuries have been reported. Berlin Township Police Chief Leonard Check tells Philadelphia television station NBC10 that investigators believe the explosions were likely the result of the ignition of chemicals stored inside the building. Fire officials say workers at the site were all safely evacuated. The company's website says it manufactures ion exchange resins which are used in water softening and water treatment.
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Misconceptions about the region to cost tourism Travellers' misconceptions are likely to cost tourism billions this year, according to a new survey. Nearly one in five, 18 per cent, of respondents identified unaffected areas of the 2004 tsunami as 'severely affected' or 'somewhat affected', in the Asia Travel Intentions Survey 2006 conducted by ACNielsen for Visa and the Pacific Asia Travel Association (Pata). The report into the attitudes of potential travellers to Asia showed people are more willing to visit than a year ago. Of individuals intending to travel internationally this year, 43 per cent are considering Asia. Of those, about 80 per cent said there was a more than 50 per cent chance of them doing so. However, the study highlights concerns that are holding back growth in Asian tourism. Fears of a repeat of the freak wave still cast a shadow, with 35 per cent less likely to visit Asia because of tsunami. The fearful were frequently misinformed. Sixteen months on, a significant number said that several destinations, including China, Hong Kong, Korea, Japan, the Philippines and Singapore - places unaffected by the December 2004 tsunami - were 'still severely or somewhat affected'. Travellers are also concerned about their safety in Asia, but they are just as badly informed about the locations where terrorism has occurred. Fifty-eight per cent say that terrorism threats make them less likely to visit Asia. More than two-thirds of respondents (69 per cent) are scared off by government-issued travel warnings. The Chinese market is the most nervous about travelling to other Asian countries because of safety and security concerns (82 per cent), while countries with the least concern were France (57 per cent) and Germany (50 per cent). Bird flu is now a hurdle to Asia tourism and potential travellers are equally ill-informed, with a third unsure which areas have been affected, and more than one in five believing that places with no cases have been affected. 'Travellers' perceptions do not always reflect the reality of a situation, and ignorance is costing the industry billions,' said Paul Dowling, Visa Asia-Pacific's executive vice-president for corporate relations. 'Better consumer education would bring billions of extra tourism dollars into Asia,' he added. 'We in the travel industry need to be more proactive in getting the facts in front of consumers.' China arrivals slip Arrivals to China fell 2.4 per cent year on year to 10 million this March as inbound travel from Hong Kong and Macau slowed, according to the Moodie Report. Hong Kong arrivals fell 0.7 per cent to six million, while visits from Macau residents fell 13.2 per cent to 1.9 million. Japanese arrivals were down by 4.8 per cent year on year in March. More encouragingly, South Korean arrivals climbed 4.1 per cent. Taiwanese traffic increased 8.1 per cent to 342,400. Foreign visitor arrivals rose 3.7 per cent to 1.7 million for March. For January to March, arrivals grew 1.8 per cent year on year. Foreign arrivals led the growth, climbing 6.1 per cent to 4.6 million visits. Arrivals by Hong Kong residents grew 4.1 per cent to 17.3 million, while Macau residents' visits fell 7.9 per cent to 5.8 million. Taiwanese arrivals grew 5.7 per cent to 988,400. Reputation over profit As the spotlight turns on India's fast-growing travel market, brand image is 'everything', according to Jeh Wadia, managing director of low-cost carrier GoAir. Speaking at the recent Centre for Asia-Pacific Aviation's Annual Middle East and Indian Subcontinent Aviation & Tourism Investor Summit in Mumbai, Mr Wadia said profits come second to reputation for new airlines. 'Reputation is more important than making money at first. Later, it costs ridiculous amounts of money to salvage a reputation and win back customers,' he said. Mr Wadia says GoAir cut back frequencies to maximise on-time performance and build a market position based on reliability. India's aviation market grew 30 per cent last year as low fares from low-cost carriers, including Air Deccan, SpiceJet and GoAir stimulated demand.
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2015-01-31T05:40:51Z
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Mikko Koivu has had possibly the most frustrating season of his seven in the NHL. During the season's most critical time, the Wild captain has missed 15 games in a row and 23 of the past 27. The season is 10 games from being over, yet he's about to return from a shoulder injury Thursday night against the Calgary Flames. What can he possibly accomplish as his team is nearing mathematical elimination from postseason contention? If you know Koivu, team goals, of course. "Last game we showed we can play any team in this league. Beating Vancouver 2-0 should give us a lot of confidence going forward," Koivu said Wednesday. "We have 10 more games to go, and we've got our goals in the room what we want to show we can do in the last push here. "Obviously, [it's] not the spot where we want to be, but all we can do is play as good as we can, as hard as we can the last 10 games and see where we're at after that." Koivu will return to his normal No. 1 center position between linemates Dany Heatley and Devin Setoguchi. Coach Mike Yeo will monitor his minutes, but Yeo joked that Koivu wouldn't be too pleased if he doesn't get regular ice time. Koivu said the Wild had to be patient and "make sure we don't do the mistakes that we did" previously. Koivu tried to rush back from the initial shoulder injury in January and aggravated his shoulder after only four games. Now he feels good and is "nervous in a good way" to get back into action. "You just see it in practice, it just raises the level of our practice," Yeo said of Koivu's presence. "It just raises the level of everything that's going on. It should provide a big lift for our group." The Wild is 8-16-3 without Koivu this season, and the year's downfall began in December when he missed four games because of a knee injury. "You look at what's happened with us, I think if anything we should all appreciate how valuable he is to our organization," Yeo said. "Certainly we lost some other guys, but he's such a warrior in the way he goes out. His will to win is so high that it's infectious on the rest of the group." Some have wondered why the Wild even bothers to let Koivu play. If the Wild shuts him down, it arguably could further assure a top-five pick in June's draft. But Yeo says the Wild is trying to change the culture of being a losing team. "We want to win hockey games, and we know how important he is to give us a chance to do that," Yeo said. "He was really starting to play great hockey before he got hurt. For him to come back and hopefully build off of that and have something where he can feel good going into the summer is only going to help him that much more going into next season. "We're not packing it in here. It's important to our organization as far as the mentality of how we see ourselves. We consider ourselves to be winners here. We want to do what winners do." Lundin has surgery The Minnesota homecoming for defenseman Mike Lundin has officially ended. The former Apple Valley High School standout underwent successful surgery on a sports hernia and should make a full recovery in two to three months. Lundin, who started the season with a back injury, played hurt all year and was a healthy scratch often, had two assists in 17 games. Defenseman Justin Falk, who has missed six games because of a knee injury, has resumed skating and might return next week. • With defenseman Sean Lorenz's senior season with Notre Dame over, the Wild will sign the 2008 fourth-round pick to an AHL amateur tryout. He should join the Houston Aeros in Chicago this weekend and likely will soon sign an AHL contract for next season. • Mikael Granlund, the Wild's 2010 first-round pick, is expected to return for IFK-Helsinki's first playoff game against cross-city rival Jokerit on Thursday. Granlund, like several teammates, missed several games because of a virus.
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2015-01-31T06:05:33Z
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Dinner in Less than Twenty Minutes We like cheap and easy when it comes to cooking without sacrificing taste. Who doesn’t? Anything that can give you all this becomes a culinary classic (a keeper!). Some nights you just don’t want to spend two hours making dinner. The beauty of this recipe is that most of the work is prep, cooking takes less than ten minutes and it allows for dozens of variations so you’ll never get bored with it. The original recipe was for chicken, but we experimented and made it with pork and then fish. To celebrate spring, we’ll go with the lighter version here. The showcase of this dish requires exactly three ingredients: hummus, panko and tilapia filets. The method is so simple a child could do it: spread hummus over fish, coat in panko, heat oil in a pan and brown for approximately two and half minutes on each side. It is done! For $20 you can probably feed four people. You only need enough oil to cover the surface of the pan, we’re not deep frying. You may use your oil of choice – olive or extra virgin olive oil will be the healthier choice. The result will always be the same: a juicy interior and a crunchy exterior. You can sprinkle some salt and pepper over fish before adding hummus, but most prepackaged hummus already have salt added – and your toppings should be taken into consideration regarding the salt content you are comfortable with. You can season the panko with cayenne, garlic powder or dried herbs, if you wish. Can you substitute the panko with breadcrumbs? Absolutely, but the result will be less crunchy. It will still be pretty darn good. Make sure your oil is hot, otherwise your fish will cook but the coating will fall off it. It will look messy, but it will cook to the right texture (only separately) and you can serve this disaster without anyone knowing you screwed up because it will become a breaded topping that tastes really good. To finish off the dish you can do any number of things that will change it slightly and in ever more interesting ways. Once you take the fish out of the pan, you can add a pat of butter and melt it, add herbs to heat through and cover the fish with it. A squirt of lemon juice makes it tangy and refreshing. The same can be done with capers, diced fresh tomatoes and chopped garlic. This step can be done in another minute or two. If you prefer, you may add a tablespoon of sour cream or yogurt over the fish with chopped herbs (scallions, parsley or dill are good choices). A modified pico de gallo salad over the fish, with red onion, tomatoes and avocado gives it a tropical feel. Tabouleh gives it a more Middle Eastern feel. I have also topped my fish with chimichurri sauce. Don’t think reserving some hummus and topping your fish with it as redundant but rather as daring and delicious. A simple bean, pasta or tossed salad on the side completes this dish for the perfect dinner in less than twenty minutes. Alternatively, a bed of steamed spinach gives it a very elegant sophistication. Once you’ve exhausted the hummus combinations, you can substitute with your favorite dip or sauce – pesto, roasted pepper, guacamole, baba ganoush. It could not be easier or more delicious. Plus it is so good for you that you can splurge on dessert with no guilt.
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Visiting Thailand? In and around Chiang Mai you will find a bit of everything. Chiang Mai is an ideal travel destination in Thailand. It offers culture and adventure, nature and architecture, shopping and leisure, and much more. Because of its beauty, many Thai know it as the “Rose of the North”. The best moment to visit Chiang Mai is during one of the yearly festivals. Click here to read more about what is happening during the major festivals. Chiang Mai has several museums where you can enjoy art or explore the rich history and culture of the city and its surroundings. Click here to find out more about the various museums in Chiang Mai. Sightseeing or Hiking While visitors may spend several day exploring the city with its many temples and museums, Chiang Mai is also an ideal starting point for sightseeing tours. Day trips to Mae Sa valley offer nature and adventure, with waterfalls, elephant camps and botanic gardens. Visit the highest mountain of Thailand, or go to Doi Suthep, the temple in the hills near Chiang Mai. There are hundreds of hiking tracks in the mountains near Chiang Mai. Whether you like shopping or not, you will probably do some shopping when you visit Chiang Mai. There is an abundance of handicrafts and other curiosities available in the many shops, markets, night bazaar, and in villages surrounding Chiang Mai. When you are visiting Chiang Mai it is nice to know what weather to expect. Fortunately, Chiang Mai has a very pleasant climate, especially from the end of the rainy season in October until the next monsoon arrives in May. Chiang Mai is a good starting point for bird watching. Click here for a list of birds of Thailand. Many of these can be found in and near Chiang Mai. Every season of the year Chiang Mai province produces a variety of healthy fruits. Click here to find more information about tropical fruits. Hotels and Guesthouses Chiang Mai has a wide range of hotels and guesthouses. Every visitor will be able to find affordable accommodation. The hotels that are most popular are the ones located near the Chiang Mai Night Bazar. A bit of everything We started by saying that Chiang Mai offers a bit of everything. Yes, almost everything. For diving or snorkeling you better go to the south of Thailand, but apart from that Chiang Mai is the ideal town to visit in Thailand. Many tourists have already discovered Chiang Mai, and many of them come back several times as there is always more to see and do in Thailand’s “Rose of the North”. The name of the rose The “rose of the north” is Chiang Mai. But perhaps it is good to know that the name Chiang Mai is sometimes written as “Chiengmai” or “Chiangmai”. But what’s in a name? A rose is a rose is a rose, and as Shakespeare already wrote (in Romeo and Juliet): “a rose by any other name would smell as sweet”
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2015-01-28T16:06:28Z
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Thoughts, Stories, and Bits of Wisdom For my friends on Facebook, you can go back to your regularly scheduled programming as this post is a rehash of my Facebook post. Well my friends, the deed is done! I had my Brachytherapy on Wednesday, November 27 and all went well. So, following one spinal, one nap, one probe and 22 needles, I am now the proud owner of 86 radioactive iodine-125 seeds that were implanted during the procedure and I have an ultrasound picture to prove it. Just before the anesthesiologist put me out, I was joking with the radiation technologist that I should at least get a picture out of the deal. She came into the recovery room and gave me one! How great is that? There are a couple of good things that came out of this process. First, no damn broccoli for the next 6 months. I need to avoid all foods and juices high in vitamin C, E, zinc, and selenium. Second, I have met some wonderful medical personnel. Not a dud in the bunch. I have to avoid being closer than 6 feet to children under 10 and pregnant women for any prolonged periods for the next 2 months. Quick hugs are OK but that’s it. I’m feeling great, albeit still a little sore, and dealing with some minor after effects which were anticipated and right on time. I have a CT scan and MRI scheduled for the end of December where they will check my progress and count every seed to be sure none of them have decided to migrate to another part of my body. Apparently there are no issues if they do. They just like to know where they are. Me too! I also have a bright yellow card I need to carry with me for the next two years in case I set off radiation detectors at airports or border crossings. They said not to show the card unless I set off the detectors otherwise it can confuse the security personnel. The last thing I want is a cavity search! For those of you that have been checking in, I offer my heart felt thanks. It means a lot.
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http://oneoldsage.com/2013/12/06/the-deed-is-done/
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(Via the Drudge Report) Note to folks from Michigan--Please don't be mad I'm picking on your state. It's nothing personal; it isn't even that Yankee thing. (Well, OK, maybe a little.) It's that whole "If you can't be a good example, then you'll just have to serve as a horrible warning" thing. Ya'll are the best horrible example I've seen yet. Even the loons in California are doing better than this. Why don't you throw that loser governor of yours out and start over?
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CC-MAIN-2015-06
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2015-01-28T16:12:50Z
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Purchase $75 or more on Bedding use code: BSND15 This item cannot be purchased online at this time, please call us or email us for further information. Phone: (601) 362-7257 How exciting it will be to teach your child these basic tools and see how much fun they'll have in this Fun Rugs Fun Time Fun Toolbox Rug. Whether into building or fixing things, everything that youll find in your hard-workers toolbox is here. Construction, building, undoing and putting back together, these tools will get you there. Enhance and inspire your childs creativity by using the tools on this rug to help him or her imagine and design anything and everything. Hammer, wrench, power-tool, saw, goggles, gloves, Phillips screw, scalpel, ruler, nails, screws, cone, pliers, and more. You never know, they can become so interested they will eventually want to learn architecture or engineering, even build his or her own house. Review / Comments Write a review Follow us for savings Please Visit Our Store When in Mississippi ©2015 Cullen's PlayPen Inc.
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CC-MAIN-2015-06
http://www.babysupermarket.com/BabySupermarket/Fun-Rugs-Fun-Time-Fun-Toolbox-Rug/PAEHICIGGNKNOJLI/10269/Product
2015-01-28T17:28:27Z
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- THE MAGAZINE - CATEGORY FOCUS - BEVERAGE R&D Click here to vote for this product in the August New Products Poll (ends 9/19/14). In celebration of its 18th anniversary, Stone Brewing Co. launched its Stone Anniversary IPA. The beer is a dry-hopped imperial IPA that features El Dorado hops in addition to five other hop varieties. However, the El Dorado hops stand out and add herbal, lemongrass, tropical fruit and lemon candy flavors to the beer, the company says. The beer also features malted barley, which contributes subtle cocoa, coffee and roast flavors, it adds. The ale is available in 22-ounce bottles and on draft at retailers, restaurants and bars in select markets nationwide. It contains 8.5 percent alcohol by volume and 75 International Bitterness Units. Stone Brewing Co., Escondido, Calif. Distribution: Select markets
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http://www.bevindustry.com/articles/87749-stone-anniversary-ipa
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US 7680543 B2 The present invention provides devices and systems, as well as methods, of electric field delivery and ablation (e.g., non-thermal ablation) of target tissues, including cancerous cells and solid tumors. A method of the present invention can include applying an alternating current to a target tissue and removing ablated or liquefied tissue from the target tissue region. 1. A method of destroying cancerous cells of a tissue, comprising: applying an alternating current to a target tissue region so as to non-thermally ablate cancerous cells within the target tissue while maintaining ablated tissue temperature elevations at less than about 10 degrees C., the applied current liquefying at least a portion of the target tissue; and removing liquified tissue from the target tissue region. 2. The method of 3. The method of 4. The method of 5. The method of 6. The method of 7. The method of 8. The method of 9. The method of 10. The method of 11. The method of 12. The method of 13. A method of delivering an electric field to a tissue and destroying cancerous cells, comprising: positioning a plurality of electrodes within a target tissue region comprising cancerous cells, the plurality comprising a first electrode and a plurality of secondary electrodes spaced from the first electrode; applying an alternating electrical current to the target tissue so as to establish current flow between the first electrode and secondary electrodes, and in a plurality of different directions through the target tissue, and selectively ablate cancerous cells of the target tissue region around the first electrode, the current comprising a frequency of less than about 300 kHz, and wherein the applied electrical current is selected such that elevation in target tissue temperature during current application is less than about 10 degrees C. above body temperature; and removing ablated tissue from the target tissue region. 14. The method of 15. The method of 16. The method of 17. The method of 18. The method of 19. The method of 20. The method of 21. The method of 22. A method of delivering an electrical field to a tissue, comprising: advancing a probe comprising a plurality of electrodes to a target tissue region comprising cancerous cells, the plurality comprising a first electrode and a plurality of secondary electrodes spaced from the first electrode, and positioning the plurality of electrodes so as to at least partially define an ablation volume with the positioned secondary electrodes, with the first electrode disposed within the ablation volume; applying in a first mode an alternating current so as to establish current flow between the first electrode and secondary electrodes and provide electric fields extending radially through the volume or in a plurality of different directions, and selectively destroy cancerous-cells compared to non-cancerous cells within the volume while maintaining target tissue temperature elevations at less than about 10 degrees C., the current comprising a frequency of less than about 300 kHz; removing treated tissue from the target tissue region. 23. The method of 24. A method of delivering an electrical field to a tissue, comprising: advancing a probe comprising a plurality of electrodes to a target tissue region comprising cancerous cells, the plurality comprising a first electrode and a plurality secondary electrodes spaced from the first electrode, and positioning the plurality of electrodes so as to at least partially define an ablation volume with the positioned secondary electrodes, wherein the first electrode is disposed within the ablation volume; applying an alternating current in a first mode so as to establish current flow between the first electrode and one or more secondary electrodes, and in a plurality of different directions or extending radially through the volume, and selectively destroy cancerous cells compared to non-cancerous cells within the volume, the current-comprising a voltage field of less than about 50 V/cm and a frequency of between about 50 kHz and about 300 kHz; detecting a temperature of the target tissue region during current application; and modifying the applied electric current at least partially in response to a change in detected temperature such that target tissue temperature elevations during current application are maintained at about 2 degrees C. to about 10 degrees C. above normal body temperature during the first mode for cancer cell destruction. 25. The method of 26. The method of This application claims the benefit under 35 U.S.C. §119(e) of U.S. Provisional Patent Application No. 60/825,660, filed Sep. 14, 2006, and U.S. Provisional Patent Application No. 60/863,484, filed Oct. 30, 2006, the full disclosures of which are incorporated herein by reference. This application is related to U.S. application Ser. No. 11,855,956, entitled “Device and Method for Destruction of Cancer Cells,” filed on Sep. 14, 2007, and U.S. application Ser. No. 11/855,940, entitled “Ablation Probe With Deployable Electrodes,” filed on Sep. 14, 2007, both of which are being filed concurrently herewith, the full disclosures of which are incorporated herein by reference. The present invention relates generally to electric field delivery to tissue regions. More specifically, the present invention relates to electric field delivery and non-thermal ablation of target tissue regions, including selective ablation of cancerous cells and solid tumors. Current tissue ablation techniques rely on a high-frequency, hyper-thermia inducing electric current to the tissue of a patient (e.g., human, animal, etc.) as a means to remove unwanted tissue or lesions, staunch bleeding, or cut tissue. There has been increased interest and activity is the area of hyper-thermal ablation as a tool to treat cancer by heat-induced killing and/or removal of tumor tissue. In hyper-thermal tumor ablation techniques, high-frequency RF (e.g., “RF thermal ablation”) or microwave sources are used to heat tissue resulting in histological damage to the target tissue. In RF thermal ablation techniques, for example, high frequencies, including about 500 kHz and greater, are used to cause ionic agitation and frictional (e.g., resistive) heating to tissue surrounding a positioned electrode. Lethal damage to tissue (e.g., denaturation of tissue proteins) occurs at temperatures in excess of about 47 degrees C., though heat generated near electrodes in RF thermal ablation can reach temperatures up to or exceeding about 100 degrees C. A number of different cancer ablation methods and devices relying on hyper-thermal ablation or heat-induced tumor tissue destruction have been proposed. One such example includes U.S. Pat. No. 5,827,276, which teaches an apparatus for volumetric tissue ablation. The apparatus includes a probe having a plurality of wires journaled through a catheter with a proximal end connected to the active terminal of a generator and a distal end projecting from a distal end of the catheter. Teachings include a method and probe deployable in a percutaneous procedure that will produce a large volume of thermally ablated tissue with a single deployment. U.S. Pat. No. 5,935,123 teaches an RF treatment apparatus including a catheter with a catheter lumen. A removable needle electrode is positioned in the catheter lumen in a fixed relationship to the catheter. The treatment apparatuses are taught as being used to ablate a selected tissue mass, including but not limited to a tumor, or treat the mass by hyperthermia. Tumor sites are treated through hyperthermia or ablation, selectively through the controlled delivery of RF energy. Numerous other methods and devices are taught using hyper-thermal or heat-induced cancer tissue destruction. However, a significant limitation of RF induced, hyper-thermal ablation is the difficulty of localizing the heat-induced damage to targeted cancerous tissue while limiting histological damage and destruction to surrounding healthy, non-target tissue. Thus, there is a need for minimally invasive ablation techniques that selectively destroy cancerous cells while minimizing damage to healthy tissue. The present invention provides systems, devices and related methods for applying electric fields for cancerous cell destruction and tissue ablation, e.g., non-thermal tissue ablation. Devices of the present invention will generally be designed to advance an electrode or plurality of electrodes to a target tissue region and apply an electric field to the target tissue region. The electrode or plurality thereof can be positioned such that the applied electric field radiates throughout the target tissue region, including, for example, where the electric field radiates outwardly and in a plurality of directions radially through the target tissue. Additionally, the energy applied to the target tissue region can be selected such that electrically generated heat is minimized and elevations in tissue temperature can be avoided. In particular embodiments, the applied electric field is generally a low-intensity (e.g., less than about 50 V/cm) and intermediate frequency (e.g., between about 50 kHz and 300 kHz) alternating current field sufficient to provide low-power or non-thermal ablation of target cells. The electrode positioning and application of the electric field (e.g., low-power/non-thermal ablative electric field) of the present invention has demonstrated to be surprisingly effective in ablating cancerous cells can occur without a thermal effect being a factor in the ablation process. Moreover, the ablative process according to one embodiment of the present invention primarily occurs among abnormally proliferating cells or cells exhibiting unregulated growth (e.g., cancerous cells). Thus, the present invention provides the additional advantage of providing minimally invasive, selective ablation or destruction of cancerous cells, while leaving normal cells or tissue substantially intact. In one aspect, the present invention includes methods of destroying cancerous cells of a tissue. Such a method includes applying an alternating current to a target tissue and removing liquefied tissue from the target tissue region. Methods of delivering an electric field to a tissue and destroying cancerous cells are also provided. Such a method includes positioning an electrode within a target tissue region comprising cancerous cells and applying an alternating electrical current to the target tissue so as to non-thermally ablate cancerous cells of the target tissue, and removing ablated tissue from the target tissue region. In another embodiment, a method includes advancing a probe comprising a plurality of electrodes to a target tissue region comprising cancerous cells, and deploying the plurality of electrodes to at least partially define an ablation volume. The method can additionally include applying an alternating current to the ablation volume to destroy cancerous cells within the volume, and removing liquefied tissue from the target tissue region. The present invention further includes devices, including those for delivering an electric field to a tissue to destroy cancerous cells therein. In one embodiment, a device includes a probe having one or a plurality of electrodes positionable at a target tissue region; and a tissue removal member for removing ablated tissue from the target tissue region. Systems for destroying cancerous cells of a tissue are also provided. A system can include a probe having electrode(s) positionable at a target tissue region, an energy source coupled to the prove to provide electrical current to ablate cancerous cells of the target tissue, and a removal unit configured for removing tissue from the target tissue. For a fuller understanding of the nature and advantages of the present invention, reference should be made to the ensuing detailed description and accompanying drawings. Other aspects, objects and advantages of the invention will be apparent from the drawings and detailed description that follows. The present invention provides systems and devices, and related methods for low-power or non-thermal tissue ablation. According to the present invention, an electrode or plurality of electrodes can be introduced into a target tissue region and an electric field applied to the target tissue region. The energy applied to the target tissue region can be selected such that electrically generated heat is minimized and rises in tissue temperature can be avoided, thereby providing low-power or non-thermal ablation of target cells. Devices and methods of the present invention have been demonstrated to be effective in ablating cancerous cells without a thermal effect being a factor in the ablation process, with ablation occurring primarily among abnormally proliferating cells or cells exhibiting unregulated growth (e.g., cancerous cells). Thus, the present invention is advantageous in providing minimally invasive, selective ablation or destruction of cancerous cells, while leaving normal cells or tissue substantially intact. In one embodiment, the target tissue region includes a mass or solid portion of tissue. Typically, the target tissue region includes cancerous cells including, for example, a target tissue region including a solid tumor. The volume of the tissue to be subject to the inventive methods can vary, and will depend at least partially based on the size of the mass of cancerous cells. Peripheral dimensions of the target tissue region can be regular (e.g., spherical, oval, etc.), or can be irregular. The target tissue region can be identified and/or characterized using conventional imaging methods, and various imaging systems can be used for locating and/or positioning of a device or electrodes of the invention within a patient's tissue or at or within a target tissue region. Electrodes can be positioned as described and an alternating electric field applied. Ablation techniques according to the present invention can be accomplished in some embodiments without an increase in local tissue temperature and without thermal effects of energy application being a primary means by which tissue ablation occurs. The applied electric field can include a low-intensity, intermediate frequency alternating current. In some embodiments, electrode configuration and field application can take advantage of tumor physiology, including, e.g., orientation of dividing/proliferating cells within a target tissue region, and ensure that the electric field provided is substantially aligned with a division axis of a dividing cancerous cell. The present invention can include a variety of electrode compositions, configurations, geometries, etc. In certain embodiments, electrodes can include tissue-penetrating electrodes including, for example, small diameter metal wires having tissue-piercing or sharpened distal ends that can penetrate tissue as they are advanced within the target tissue region. Electrodes can be non-insulated or can include an insulated portion. In one embodiment, a non-insulated portion of the electrode provides an electric field delivery surface for delivery of electrical current to the surrounding tissue. Electrodes can be substantially rigid, e.g., so as to be more easily advanced through tissue, including hardened or more dense tissue, or can be more flexible, depending upon the desired use. In one embodiment, an electrode includes a needle or needle-like electrode or electrode having a substantially linear portion. In another embodiment, electrodes can be curved, having a curved portion or portion with a radius of curvature. Electrode composition can vary and in certain embodiments can include a memory metal (e.g., commercially available memory metals, Nitinol™, etc.) or sprung steel. Suitable electrode materials can include, e.g., stainless steel, platinum, gold, silver, copper and other electrically conductive materials, metals, polymers, etc. In certain embodiments, electrodes can be positioned in and deployable from a lumen of a catheter and/or microcatheter or other member for introducing the electrode into a tissue. In another embodiment, the present invention can make use of one or more sensor mechanisms to provide feedback and/or control the ablation process. Sensor mechanisms can include sensors or detectors that detect and measure parameters such as temperature, current, voltage, impedance, pH and the like. Certain embodiments of the present invention can include modifying the applied electric current at least partially based on a detected characteristic or a change in a detected characteristic. In one embodiment, for example, modification of the applied electric current can occur in response to a measured temperature, impedance, and the like. Modification can include, for example, modifying the voltage, frequency, etc. of the applied current and/or discontinuing application of the electric current, for example, where the ablation process or a stage thereof is determined to be completed. A target tissue region can be located anywhere in the body where the tissue ablation methods of the present invention would be desired or beneficial. Target tissue is not limited to any particular type and non-limiting examples can include, e.g., breast tissue, prostate tissue, liver, lung, brain tissue, muscle, lymphatic, pancreatic tissue, colon, rectum, bronchus, and the like. The target tissue region will typically include a mass or solid portion of tissue. Typically, the target tissue region includes cancerous cells including, for example, a target tissue region including a solid tumor. The term “cancerous cell”, as used herein, generally refers to any cells that exhibit, or are predisposed to exhibiting, unregulated growth, including, for example, a neoplastic cell such as a premalignant cell or a cancer cell (e.g., carcinoma cell or sarcoma cell), and are amenable to the ablation methods described herein. The volume of the tissue to be subject to the inventive methods can vary depending, for example, on the size and/or shape of the mass of cancerous cells, as well as other factors. Peripheral dimensions of the target tissue region can be regular (e.g., spherical, oval, etc.), or can be irregular. Imaging systems and devices can be included in the methods and systems of the present invention. For example, the target tissue region can be identified and/or characterized using conventional imaging methods such as ultrasound, computed tomography (CT) scanning, X-ray imaging, nuclear imaging, magnetic resonance imaging (MRI), electromagnetic imaging, and the like. In some embodiments, characteristics of the tumor, including those identified using imaging methods, can also be used in selecting ablation parameters, such as energy application as well as the shape and/or geometry of the electrodes. Additionally, these or other known imaging systems can be used for positioning and placement of the devices and/or electrodes in a patient's tissues. As set forth above, the electrode is positioned within the target tissue region and the applied electric field is sufficient to provide low-power or non-thermal ablation of target cells. The term “non-thermal ablation” as used herein generally refers to techniques of the present invention including the removal of or destruction of the function of tissue or cells of a tissue by application of an electric field, and where the energy application/delivery process occurs without a substantial increase in local tissue temperature and without thermal effects of energy application being a significant or primary means by which tissue ablation occurs. In many embodiments, an increase in local tissue temperature can be avoided altogether, with no resulting increase in temperature being detectable in the target tissue region. In some embodiments, however, small changes/elevations in temperature in the target tissue region may occur, but will typically be no more than a few degrees C. above body temperature (e.g., less than about 10 degrees C., but typically no more than about 2 degrees above body temperature), and without the thermal effects being the primary means by which tissue ablation occurs (e.g., no significant thermally-mediated, lethal protein denaturation). Typically, the applied electric field includes a low-intensity, intermediate frequency alternating current. The intermediate frequency employed according to the present invention, for example, will be less than that typically required for frictional/resistance heating to tissue surrounding the electrode (e.g., less than about 400 kHz, preferably about 300 kHz or less). In one embodiment, for example, the electric current provides a voltage field less than about 50 V/cm. In another embodiment, the electrical current includes a frequency between about 50 kHz and about 300 kHz. The voltage field and/or the frequency and/or the magnitude of the applied current can be held constant during energy application or varied. One or more treatment phases can be applied, with each phase having selected treatment parameters (e.g., energy parameters, duration, etc.). In some embodiments, providing a non-constant or varying voltage and/or frequency and/or current by “scanning” across a given range may be desired, for example, to ensure that the optimal ablative voltage/frequency/current is applied to the target tissue region. In another embodiment, a particular voltage and/or frequency and/or current can be selected prior to energy application. Furthermore, the electrode(s) can be positioned within the target tissue region such that electrical current application occurs from within the target tissue, and the target tissue is ablated from the inside out. In one embodiment, electrode(s) are positioned within the target tissue region (e.g., tumor) and the applied electrical current provides an electric field extending radially outward from the electrode. In certain embodiments, such positioning can take advantage of tumor physiology, including, e.g., orientation of dividing/proliferating cells within a target tissue region, and ensure that the electric field provided by the electrode is substantially aligned with a division axis of a dividing cancerous cell. In some embodiments, devices and/or systems of the present invention include electrically floating systems or systems designed to operate without an earth grounding. In some instances, it was observed that electrode configurations that were electrically floating in this manner allowed more accurate or controllable field application and/or delivery. The low-power requirements of systems according to certain embodiments allow more design options (e.g., battery operation) in configuring devices and systems that are electrically floating, as described, compared, for example, to known techniques such as thermal RF or microwave ablation, or high-voltage irreversible electroporation that require much higher powered energy delivery and corresponding power sources. Another embodiment of a device of the invention is described with reference to Electrodes of a device according to another embodiment of the present invention are described with reference to A device can include a plurality of electrodes, each deployable or retractable in and out of a microcatheter, with each microcatheter/electrode assembly optionally positioned within a central lumen of a larger delivery member, as illustrated in In use, as shown in The present invention can include various means of accessing or addressing a target tissue and positioning electrodes/probes for delivery of the described ablative treatment. Typically, positioning of a device of the invention will include a minimally invasive access and positioning techniques, including, e.g., access techniques commonly used with other types of tissue ablation (e.g., thermal RF ablation, microwave ablation, high-voltage electroporation, and the like). For example, devices of the invention can be introduced percutaneously through the skin and advanced through tissue and positioned at a target tissue. Though, addressing a target tissue and positioning of a device can occur in conjunction with more conventional surgical techniques or laparoscopic techniques. As set forth above, certain embodiments of the present invention include positioning of an electrode within the target tissue region and applying an alternating electrical current, with the applied electrical current providing an electrical field that radiates outwardly from the positioned electrode. Electric field application in this manner was found to be highly effective in disrupting and destroying cancerous cells via low-power ablation and in the absence of a thermal ablative effect. In certain embodiments, disruption of cancerous cells and resulting ablation according to the present invention even more effectively occurred where the electrical field provided by an electrode of an inventive device was substantially aligned with a division axis of a dividing cancerous cell or plurality of cells. Furthermore, the electric field application as described was observed to be particularly effective in selectively disrupting and destroying the dividing cancerous cells, while having little or no effect on normal cells that were not exhibiting unregulated growth and proliferation. Without being bound by any particular theory, electric field application as described may specifically disrupt the cell division process (e.g., mitosis) or progression through the cell cycle, or a stage or process thereof (e.g., mitotic spindle formation, microtubule polymerization, cytoplasmatic organelle function or arrangement, cytokinesis, cellular osmotic balance or the like) and, therefore, more particularly effects cells exhibiting unregulated growth (e.g., cancerous cells) and progressing more rapidly through the cell cycle. According to the present invention, a target tissue region can be ablated in whole or in part. It will be recognized that while it is generally desirable to ablate as much of the target region or tumor as possible, in some embodiments, methods can include ablation of a portion or less than the entirety of the target region. In some instances, partial tumor ablation can be sufficient to ultimately destroy or kill an entire tumor or cancerous tissue region. Use of a device according to an embodiment of the invention (e.g., the device of Another embodiment of a device of the present invention is illustrated in As the ablation process is initiated, the field intensity is highest at the inner or central electrode and within tissue around and in close proximity to the inner or central electrode. As the ablation process progresses, cancerous cells near the inner electrode are observed to be destroyed or ablated first. The ablated cells effectively “liquefy” or assume properties of a low impedance, liquid-like material. The term “liquefy” is used herein for convenience and illustrative purposes, and does not necessarily imply any particular mechanism of ablation or cell death, which may include cell blebbing, apoptosis, lysis, or some other cellular process, and/or some combination thereof. Another possible cause of cell destruction may include disruption of cellular membrane integrity, e.g., including dielectric breakdown of one or more cellular membranes (see, e.g., below). The liquid-like material surrounds the central electrode and effectively enlarges the higher field intensity ablative area, with the highest field intensity ablative area being at the outer perimeter of the liquid-like material. Thus, the liquid-like material is said to become a “virtual electrode”. As the ablation process progresses, the outer perimeter of the liquid-like material or “virtual electrode” expands, essentially ablating the target tissue region from the inside out. In some embodiments, target tissue regions were observed to be more pliable and soft or mushy following the ablation process. The ablated, liquid-like tumor tissue was eventually removed from the treatment site and/or absorbed by the surrounding tissue, and no longer detectible. The virtual electrode effect is illustrated with reference to The ablation process, including the progress thereof, can be monitored by detecting the associated change in impedance in the ablated tissue. Once the outer perimeter of the ablated, liquid-like tissue reaches the outer electrodes defining the ablation volume, the impedance stabilizes or levels out. Thus, the progress of the ablation process can be monitored by measuring change in impedance, and electric field application discontinued once a change in impedance is no longer observed. Feedback measurements can also be used to ensure that the ablation of the target cancerous cells occurs by non-thermal ablation. In certain embodiments it may be desirable to generate as much field intensity at the inner electrode as possible without causing a hyper-thermal effect or thermal ablation. Certain hyper-thermal effects would be observable and distinguishable from the desired non-thermal ablation of the present invention, since thermal ablation would cause destruction of the surrounding cells without the “liquefying” effect described above. For example, if cell destruction is caused by a thermal ablation process, the impedance of the treated tissue may not decrease since the impedance of cells that are charred or become necrotic due to thermal effects typically increases. In one embodiment, non-thermal ablation according to the present invention can include placement of a sensor, such as a thermocouple, within the target tissue region (e.g., proximate to the inner electrode), and selection of an applied field intensity as below the intensity that would cause thermal effects on the target cells. As stated above, in some instances, it may be desirable to increase the field intensity emanating from the position of the inner electrode within the target tissue region. In one embodiment of the present invention, field intensity can be increased by increasing the surface area of the inner electrode that is placed within the target tissue region. Various embodiments of increased surface area electrodes are illustrated in Another embodiment of a device of the present invention is shown in Another embodiment of a device of the invention is described with reference to A system according to an embodiment of the present invention is described with reference to A control unit can include a, e.g., a computer or a wide variety of proprietary or commercially available computers or systems having one or more processing structures, a personal computer, and the like, with such systems often comprising data processing hardware and/or software configured to implement any one (or combination of) the method steps described herein. Any software will typically include machine readable code of programming instructions embodied in a tangible media such as a memory, a digital or optical recovering media, optical, electrical, or wireless telemetry signals, or the like, and one or more of these structures may also be used to transmit data and information between components of the system in any wide variety of distributed or centralized signal processing architectures. Components of the system, including the controller, can be used to control the amount of power or electrical energy delivered to the target tissue. Energy may be delivered in a programmed or pre-determined amount or may begin as an initial setting with modifications to the electric field being made during the energy delivery and ablation process. In one embodiment, for example, the system can deliver energy in a “scanning mode”, where electric field parameters, such as applied voltage and frequency, include delivery across a predetermined range. Feedback mechanisms can be used to monitor the electric field delivery in scanning mode and select from the delivery range parameters optimal for ablation of the tissue being targeted. Methods and techniques of the present invention may employ a single device or a plurality of devices. In one embodiment, for example, a device of the present invention (e.g., device as illustrated in Systems and devices of the present invention can, though not necessarily, be used in conjunction with other systems, ablation systems, cancer treatment systems, such as drug delivery, local or systemic delivery, radiology or nuclear medicine systems, and the like. Similarly, devices can be modified to incorporate components and/or aspects of other systems, such as drug delivery systems, including drug delivery needles, electrodes, etc. While some embodiments of the present invention can include positioning of an electrode directly within the target tissue region, in some instances it may be desirable to apply an electric field as described above, through the target tissue region (e.g., radially), in the absence of an electrode positioned within the defined ablation volume. Referring to In some embodiments, systems of the present invention can further include certain components and aspects for positioning and/or stabilizing probes and other components during the energy delivery process. For example, in instances where a phase of treatment, such as energy application, is expected to exceed more than a few minutes, it may be desirable to include a positioning or stabilizing structure to maintain a probe in a desired position/location without specifically requiring a user (e.g., surgeon) to hand-hold the probe. Thus a system can include a harness, belt, clamp, or other structure to maintain probe positioning. Systems can be designed for ambulatory use so as to allow for movement of the patient (e.g., shifting, walking, etc.) during treatment. In fact, the low-power requirements and corresponding design options (e.g., battery powered system) may make the current systems particularly well suited for use as an ambulatory system. In some instances, it may be desirable to remove ablated tissue from the target tissue region at a stage of the ablation process described herein. For example, it has been observed that, in some instances, removal of ablated tissue can improve treatment and/or recovery of the subject, and possibly reduce stress and/or toxicity (e.g., local tissue toxicity, systemic toxicity, etc.) associated with the ablation process of the present invention. Various devices and methodologies can be utilized for removing the ablated tissue. In some instances, as described above, the ablated tissue can effectively “liquefy” or assume properties of a liquid-like material. The liquid ablated tissue can then be drained or removed from the target tissue region. In one embodiment, removal of the ablated tissue can be as simple as allowing ablated tissue to leak or ooze out of target tissue region (e.g., with or without application of a force or pressure to the target tissue region or tissue proximate thereto), for example, by leaking out holes or piercings in the tissue, including, e.g., entry holes through which the device/electrodes are introduced into the target tissue region. In other embodiments, removal of ablated tissue can be more deliberate or controlled. The removal can be accomplished using a device or apparatus separate from the ablation device, such as a syringe or other liquid removing device, or the removal can be accomplished using the ablation device further configured for the tissue removal. A device configured for removal of ablated tissue can include a tissue removal member, which can be deployable from a delivery catheter. In one embodiment, the removal member includes a catheter-like member having a lumen for carrying liquid. The removal member can be separate from or combined with other components of the device, such as an electrode (e.g., central electrode), delivery member, and the like. Various configurations of removal members capable of removing ablated tissue from the target tissue region will be envisioned and certain exemplary embodiments are described herein. It will also be recognized that while removal members are discussed with respect to use in removing ablated tissue from the target tissue region, in some instances, removal members may have additional or multipurpose functionality and, for example, may be additionally used to deliver an agent or material (e.g., drug, chemotherapeutic agent, flushing buffer, etc.) to the target tissue region. As described above, various configurations and embodiments of a removal member are envisioned according to the present invention. Removal members according to exemplary embodiments of the invention are described with reference to Another embodiment of a device of the invention is described with reference to In another embodiment of the present invention, removal of liquid and/or ablated tissue can include application of a pressure or force at or proximate to the target tissue region. As illustrated in The following examples are intended to illustrate but not limit the invention. One series of testing included treatment of breast cancer tumor models. In one example, testing was done on Female Fisher-344 rats (Charles River), with body weight 230-250 grams. Rat breast cancer cells (MTLn-3) were initially grown in culture and subcutaneous tumors were produced by implanting cells from cultures into the abdomen of the animal. When the tumors grew to approximately 1 cm or greater in diameter, the ablation treatment was administered. 18 solid breast tumors in rats were treated. Ablation treatment included insertion of an ablation probe including a stainless steel needle electrode array percutaneously, through the skin and directly into the tumor, and then applying tumor treating electric fields. The needle array included a central needle surrounded with three parallel outer needles of approximate equal spacing. Probe design, including needle length and arrangement, were selected to traverse the approximate diameter of tumors being treated and needles were about 1 cm in length. The outer needles were spaced about 0.5 cm from the central needle. The central needle was activated with the tumor treating voltage, and the surrounding needles provided the return path for the current. No earth ground was provided (e.g., electrically “floating” system) where probes were operated in “bi-polar mode” as described, and the device included a battery powered source. Using the above described probe and configuration of needles, the treating field was contained within a cylinder approximately 1 cm in diameter and 1 cm long, the volume of which was substantially occupied the tumor. The applied AC voltage was about 10-12 volts peak, at about 20-30 mA (starting current). The frequency was about 98 Khz. A feedback circuit was included to measure the total current into the tumor during treatment. One hypothesis from preliminary experimentation was that when tumors cells began destruction from the applied field (e.g., lyse, disintegrate, spill cytoplasm, etc.), the current would actually increase due, for example, to increased conductance within the tumor area due to contents of the destroyed cells (e.g., cytoplasm, etc.) being more conductive than cells substantially in tact. Results indicated that the circuit worked as hypothesized. The current began to increase after the start of treatment in each case, indicating that treatment was effectively taking place. Observed current increase also provided indication of when the process reached a stage of substantial completion. For example, an observation of no further increase in current indicated that treatment could be discontinued. This plateau in current was observed to occur at approximately 40 mA, and typically within approximately 90 minutes into the treatment. Tumors began to show cell destruction almost immediately after power was applied. Significant destruction occurred within 30 minutes into the treatment. In some instances, treatment was terminated after 30 minutes and the tumors were almost undetectable. In other treatment groups, treatment was completed at about 90 minutes, or within 3 hours. In all cases the treated tumor was virtually undetectable. Controls were included to confirm that tumor destruction was a result of the applied field. In one group, needles were inserted with no power applied as a control. Continued tumor growth was observed in controls. A group of rats that were treated were selected for long term viability study and were not sacrificed following treatment. Survival was confirmed at one point at greater than 12 months from the date of treatment, which was >17 times the expected survival in the animal model when not having any treatment (e.g., about 3 weeks). These rats currently remain alive. Survival observations and histological analysis (e.g., see below) indicated destruction of a vast majority, if not substantially all, of the cancer cells within target tissue subject to treatment as described. As noted above, treatment typically resulted in a sort of liquification of cancerous cells/tissue. Following treatment, a clear to pinkish fluid was observed present in the target tissue region subject to treatment, which could leak from needle entry locations and further excreted upon compression or application of pressure to the treated region. Histological analysis was performed on the fluid and the tumor area after treatment. The histology showed that the fluid primarily consisted of destroyed cancer cells, with destroyed cells appearing substantially necrotic and non-viable. Testing of pH indicated that the removed fluid was more highly alkaline (e.g., pH of about 7.8 or greater) than typical physiological fluids. Observed treatment areas were about 80-90% necrotic or non-viable cancer cells. The treated area which was not necrotic (e.g., typically about 10-20% of target tissue) appeared to be the part of the area which was healthy, non cancerous tissue. Thus, the results indicated a selective destruction of cancerous cells, while leaving healthy cells substantially unharmed or viable. The observed treatment appeared to have no significant side effects. Surviving subjects not sacrificed for further analysis have exhibited no debilitation or any noticeable signs of negative side effects (viability, behavior, or otherwise) after treatment. No significant distress or discomfort, or irritation of the treatment region, due to application of energy was observed in the subjects. During treatment the rats appear comfortable, i.e., eating, drinking, and sleeping even though they are not anesthetized during treatment. The only observation of a potential side effect appeared to be a result of non-removal of the fluid or ablated tissue following treatment. When fluid was not removed from the treatment region following treatment, subjects appeared lethargic for several hours and recovery time was increased compared to rats subject to fluid removal following ablation treatment. As noted above, treatment as described was observed to be selective in destroying cancerous cells within a defined target tissue region. Without being bound by any particular theory, one or more reasons could explain the selective nature of the described treatment. One reason for the observed selectivity appeared to be design of the ablation probe—treatment was substantially confined to a treatment volume as defined by the positioning of the electrodes. Only the tissue is within the probe's outer electrodes appeared to receive the delivered energy and that is the area the electric field almost exclusively covers. The field does not appear to extend outside of the volume defined by the outer electrodes. Second, selectivity may be inherent to the mechanism of cell destruction. The cell ablation is distinguished from a primarily thermal-mediated ablation as performed in known high-frequency RF thermal ablation, or microwave ablation techniques, nor is the effect due to high voltage irreversible electroporation by application high voltage direct current as has been previously described elsewhere. All of these previously taught methods, by design, destroy normal tissue as well as cancer. Techniques of the present invention make use of voltage, power and frequency ranges that are not within the range of thermal or high voltage ablation. Furthermore, without being bound to any particular theory, additional cellular-level effects of the current techniques may cause selective destruction of cancerous cells compared to non-cancerous cells. The energy application as described herein appears to mediate breakdown of the cell membrane integrity. One potential reason for the breakdown of the cell membrane and/or destruction of cancer cells may include disruption of cell cycle progression and cell mitosis by the applied electric field, with the disruption triggering cell destruction (e.g., necrosis, apoptosis, disintegration) as has been observed herein. Since cancer cells in a tumor are actively dividing and proliferating and, therefore actively progressing through the cell cycle/mitosis at a much higher rate compared to orders of magnitude slower rates of non-cancerous or healthy cells, this energy application as described can be selective to cancer cells. Another possible cause of cell destruction may include dielectric breakdown of the cellular membrane. Cell membranes are known to have a dielectric breakdown threshold, above which the cell is destroyed. A normal cell typically has a higher threshold than a cancer cell. Thus, it is possible to selectively breakdown a cancer cell membrane without harming a normal cell where the applied energy is above the dielectric breakdown threshold for cancerous cells but below that of normal/healthy cells. Breakdown in membrane integrity resulting from treatment as described herein may occur in both extracellular membranes as well as intracellular membranes, for example, causing rupture of lysosomes containing components (e.g., degradative enzymes, etc.) that further lead to cell destruction. Rupturing of cells and spilling of cellular contents can negatively effect nearby cells, resulting in a sort of cascade of cellular destruction. Treatment may also stimulate an immune response that can “clean up” the treatment region and may further destroy any residual/viable cancer cells not destroyed or removed. Other disruptions and/or mechanisms of action may also occur. Regardless of any particular mechanism of action, where cellular disruption occurs as described, the resulting fluid appears to further act in some instances as a sort of virtual electrode, making the electrode larger and larger in diameter, and finally substantially covering the entire target tissue region. It is understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are included within the spirit and purview of this application and scope of the appended claims. Numerous different combinations are possible, and such combinations are considered part of the present invention.
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Crider Center partners with community in Season of Giving collecting coats Crider Health Center kicked off its First Annual Season’s of Giving program on Nov. 4. The Season’s of Giving program includes a coat drive to provide the gift of warmth from the harsh winter elements. Coat donations will be accepted Nov. 4-29. “Over the last nine years, Crider has provided coats for needy children participating in various programs and services that Crider provides through our Coats for Crider program,” said Shaunna Shaw, development associate at Crider Health Center. The community is encouraged to drop off new and gently used young adult and adult sized coats to one of the following locations: • Crider Health Center – 1032 Crosswinds Court – Wentzville, MO • Crider Health Center – 19515 Brune Parkway – Warrenton, MO Troy Family Dental – 128 Professional Parkway – Troy, MO Give the gift of joy and warmth to someone in need this holiday season. To learn more about Crider Health Center’s Season’s of Giving program, or to make a donation, please contact Shaunna Shaw at 636-332-8352.
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View Full Version : Chief Justice Robert Byrd? June 29th, 2010, 01:00 AM As many may have heard, Robert Byrd, the long-serving Senator from West Virginia, passed away. Richard Nixon reportedly briefly considered him for a Supreme Court position. My question: WI Byrd had accepted? How would he have faired on the Supreme Court from the Seventies onward? June 29th, 2010, 02:41 AM Based on his OTL beliefs, he'd probably be a moderate, if not mildly left-leaning judge. Did he have any judging experience? June 29th, 2010, 02:53 AM No. He never practiced law, let alone become a judge. Many of us have seen the famous picture of JFK handing Byrd his JD from American U in '63. Insufficient experience. vBulletin® v3.8.4, Copyright ©2000-2015, Jelsoft Enterprises Ltd.
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TAMPA — A judge set bail at $55,000 Sunday for the man suspected of setting almost half of the fires in the V.M. Ybor neighborhood that left residents living in fear for the past 18 months. Kenneth Brian Smith's first appearance in court lasted only seconds as he stood in front of Circuit Judge Jack Espinosa Jr. via closed-circuit television from the Orient Road Jail. Smith, dressed in an orange jumpsuit with handcuffs around his wrists, made no comment. He remained in jail Sunday afternoon, records show. Smith, 43, was charged with the Jan. 29 arson at 1412 E 21st Ave. and is a suspect in another four fires at the same location, police Chief Jane Castor said on Friday. He is a suspect in a total of 13 fires, she said. Smith was arrested Thursday in Chicago, where he waived an extradition hearing. He arrived in Tampa late Friday night and was booked into the Orient Road Jail on one count of arson and driving with a suspended license. There have been more than 20 fires ruled as arson around Ybor City, officials said.
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Discussing Fundamental Principles (aka Groundwork) of the Metaphysic of Morals (1785). We try very hard to make sense of Kant’s major ethical principle, the Categorical Imperative, wherein you should only do what you’d will that EVERYONE do, so, for instance, you should not will to eat pie, because then everyone would eat it and there would be none left for you, so too bad. Also, Kant on free will, “things in themselves,” our duties to animals, and prostitution! Plus: Should you go to grad school? End song: “Stop” by Madison Lint (2003).
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Link to this page: http://www.socialistparty.org.uk/issue/490/2481 The Socialist 7 June 2007 | Join the Socialist Don't trust the Trust schools - organise! LAST YEAR, New Labour forced through legislation that would allow 'high-achieving' schools to go from being a community school, under democratic control from the local education authority, to becoming a Trust School which will be completely independent from the LEA. Paul Philips Chester-le-Street This would leave the community without any control or influence over the school. Many schools around the country have already applied for Trust status and these applications are currently being approved by their own internal governing bodies (the body which will gain full control of the school), by the LEAs and by the government. Hermitage School in Chester-le-Street, Durham is in its final stages of becoming a Trust school and has had to use a lot of spin to get this far. The first spin was seen in October in a school newsletter to parents directly from the governing body explaining what good would happen if Hermitage School became a Trust. A questionnaire attached asked if they want Hermitage to become a Trust school with a simple tick answer box of yes and no. The next question asked: "If you agree with Trust schools, please list the reasons why." There was no question asking why people would disagree with Trust schools. Basically it gave parents no chance of expressing reasons for opposition. Another reason why there is no real opposition is that teachers are scared to speak out. If Hermitage becomes a Trust they will be employed by the Trust, not the democratically elected council. They are also scared in case the management tweak their wages or decrease their chances of getting promoted. One anonymous teacher has said "If I speak out against the Trust I'm afraid in case I lose my position as head of department." At this stage, because of all the misinformation, most students don't have a clue about the implications of being a Trust school. Even though the consultation period started in October, only in the past two months has the governing body started to push through this proposal at a quicker rate. It looks like it has purposely been done to coincide with the students' examination period, making it harder for students to get organised. Public stalls are being held by teachers' unions and students to inform parents of what Trust schools really mean for them. One second year Sixth Former recently said "Even though I'm not going to be a student at this school next year, I am worried about the future of my siblings of not getting the comprehensive education they deserve and what impact this may have on the community". Teachers must let their voices be heard to show that Trust status is not the way forward for a quality education system. The same goes for students and parents, who should organise and tell the governing body that they don't believe going Trust is the way forward. Schools can be very top-down when proposing to become a Trust and fear can be used to stop teachers from speaking out. Organisation is the best way to stop potential privatisation of our comprehensive education system.
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February 16, 2012 Chicago Slitter, Itasca, Ill., a supplier of equipment for coil slitting, blanking, and cut to length, has announced the appointment of two new staff members. Scott Erickson has been named project engineer. He has achieved five U.S. patents in laser system design. His primary focus has been on photonic engineering, specializing in laser systems, optics, and fiber optics, as well as project management, automation, robotics, and micromachining. Paul Braddock has been appointed to the position of replacement part specialist. He has experience as an applications engineer and a product marketing specialist. He previously worked for McMaster-Carr and Siemens.
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On the occasion of Teachers’ Day, we caught up with actor-singer Ayushmann Khurrana to chat with him about his memories from school and his favourite teachers Ayushmann Khurrana, who majored in English Literature and has done Masters in Mass Communication from School of Communication Studies, went back to complete his education after he had won the popular TV show MTV Roadies. On the occasion of Teachers’ Day, when quizzed about his favourite teachers and memories from school, he said, “A lot of memories; Sunita Singh who was my class teacher in 5th standard. She was very nice to us. Also, Arjun Das, who’s no more, was my Hindi teacher in 8, 9 and 10th standard and he was really good. My Hindi is good today because of him.” He also talked about teachers in real life that had influenced him and taught him a great deal. He said, “Shoojit Sircar is a great teacher, Ashish Patil — my former boss from MTV and the present CEO of Yash Raj Films — is a great teacher, Aditya Chopra with whom am doing a movie right now is another great teacher. Also, Raghu Ram from Roadies is a great teacher.” He stressed on the need for education, which he said was absolutely essential for longevity. “They should be not biased. All these teachers I mentioned were never biased. They should be neutral to everybody and should have no prejudice,” was his message to teachers on this Teachers’ Day. Text courtesy: Indiancolleges.com
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Honor mom and help the Humane Society Delhi — Mother’s Day is approaching fast and the Heart of the Catskills Humane Society (HCHS) has some great gift giving ideas. Give the gift that gives twice, lasts a lifetime and is one-of-a-kind. Be a part of the Heart of the Catskills Humane Society’s Heart Walk and show Mom what she really means to you. This Mother’s Day, honor your mother or grandmother and help the animals at the same time. Help HCHS pave another Heart Walk Path by being a part of the second installment of the society’s beautiful Heart Walk around the shelter grounds. You may have seen the first pathway, leading from the outdoor cat gazebo, 14 feet of beautiful, locally-quarried bluestone pavers, engraved with tributes to loved ones and honoring cherished pets. On Saturday, May 23, the society will unveil the second installment of pavers, extending from the end of the first pathway toward the shelter. To be a part of that, be sure to get your order in by May 2. HCHS is selling four-inch by eight-inch pavers for $100 and eight inch by eight inch pavers for $200, which not only goes directly to help care for the animals, but which gives the donor a lasting tribute for all shelter visitors to admire. You can obtain an order form at the shelter, at the Gifts from the Heart store in Andes, or online at www.heartofthecatskills.org. Don’t miss out, get your order in by May 2! Orders received after May 2 will be a part of the third installment this fall. It takes $1,400 each day to keep the shelter doors open. Your support helps care for over 300 dogs and cats currently at the shelter. Help continue HCHS’s on its mission to help the animals in this area. And, whether or not you purchase a paver, please join us on May 23 for the unveiling of the newest part of our “pathway to forever homes.”
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The Thin in 10 Weight-Loss Plan Jessica Smith's ten minute workouts to transform your body. The Thin in 10 Weight-Loss Plan is a book by Jessica Smith and Liz Neporent aimed at helping individuals lose weight in the midst of busy schedules that don't allow for a lot of time exercising. It teaches dozens of ten minute exercises to burn calories, strengthen the core, and improve flexibility. The book includes the routines in a step-by-step photo format as well as a 60-minute DVD with additional exercises. Jessica Smith is a fitness trainer and wellness coach with a line of exercise DVDs in her "10 Pounds Down" series, as well as being co-creator of the Yin Yang Fusion DVD workout. She contributes regularly to Redbook, Shape.com, and ivillage.com, and teaches at The Sports Club/LA, EQUINOX, and Miami Beach's Canyon Ranch. Smith's co-author, Liz Neporent, is one of the most experienced fitness writers in the business as a co-author of Fitness for Dummies, Weight Training for Dummies, The Fat-Free Truth, The Winner's Brain, The Migraine Solution, and many other titles, articles, and contributions to print and online publications. Neporent holds a masters degree in exercise physiology. The fitness program is based on two popular methods of fat burning and muscle building: high intensity interval training, or HIIT, and low intensity exercises. Along with fast-paced workouts, Thin in 10 gives nutritious recipes for breakfast, lunch and dinner that can be made in ten minutes or less. The book is divided into three pillars: exercise, diet, and lifestyle, aimed at giving dieters a sustainable approach to healthy living. The program also has information for setting SMART (Specific, Measurable, Attainable, Realistic, and Timely) goals, getting adequate amounts of sleep, and the mental side of weight loss. - Quick yet effective workouts for busy people - No complicated rules or tracking - Minimal or no equipment needed - A balanced approach to a lifestyle change - Authors are both respected experts in their fields - Includes a DVD to follow along on the workouts - Those with dietary restrictions would need to modify diet section - High-intensity training may be dangerous for older adults or beginners Thin in 10 has chapters on breakfast, lunch, dinner, and discretionary calories (snacks) with recipes for each. The breakfasts are approximately 300 calories, the lunches 400 calories, the dinners 600 calories, and the snacks 200 calories, for an average of 1,500 calories per day. There is not a set schedule to follow with the meals, and they serve more as guidelines and ideas than a comprehensive eating plan. They make use of convenience foods and time-saving methods for quick meals that serve one. A typical day's meal: Breakfast: Apple 'jacks with Peanut Butter or Choco-Banana Smoothie Lunch: Turkey with Provolone & Basil Roll-Up or, "If You Must," eat out healthy with a Taco Bell Chicken Fresco Crunchy Taco Dinner: Shepherd's Pie or Sloppy Jo'sephines and Carrot-Raisin Slaw This is the meat and potatoes of the program. You start by choosing one of four plans: Get Started, Novice, Intermediate, or Advanced. True beginners do ten minutes of walking per day for at least four weeks, then move up if they're ready. The advanced plan calls for incorporating all of the different workouts in one week through 40 minutes of activity per day. Five training routines are implemented: HIIT cardio routines, which include easy moves in quick repetition with short periods of rest between Muscle building, using your body weight to build lean muscle Stretching for flexibility and overall good health Core conditioning exercises Total body circuit, the only workout that requires equipment, a resistance band, for sculpting and toning muscles A typical Intermediate Plan day is 30 minutes long, and includes: Walk: 10 minutes Cardio QUICK - interval training exercises like Plank Skis, Skaters, and Scissor Pickups: 10 minutes Core & More - abdominal exercises like Double Bicycle and Cobra Reach: 10 minutes Thin in 10 is a manageable weight loss program suitable for those with busy schedules or who lack motivation. By limiting the exercises to ten minutes, realistic expectations for exercise are set. The workouts give a sense of accomplishment after the ten dedicated and strenuous minutes to exercise. Smith and Neporent are respected leaders in their field, and focus on solutions for individuals needing to lose weight while realizing that unrealistic expectations will not achieve success. While this diet may not be comprehensive enough for everyone, it offers good ideas on how to effectively bring about lasting weight loss goals.Common Misspellings Thin in Ten, Thin in 10 Diet, Thinner in 10, Thinned in 10, Thin Ten
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On behalf of FAO/WHO Joint Secretariat we would like to thank all participants for their active involvement and their insightful comments on the political outcome document of the Second International Conference on Nutrition (ICN2). The online discussion gathered a wide range of views, allowing this process to be highly participatory and benefit from important inputs from food security and nutrition stakeholders representing Member States, UN organizations, individual academics, civil society and the private sector. A Joint Working Group of regional representatives of FAO and WHO Members is now considering all inputs received and based on these and other comments will develop the final version of the political outcome document for adoption at the ICN2 in November. For more information please see the following documents: - Background and statistics (EN FR ES) - Summary of the discussion (EN FR ES) - Contributions received, available in the proceedings and on this weboage To know more about the Second International Conference on Nutrition (ICN2) please visit the website. Thank you again for your participation. The FSN Forum Team Zero draft also available in: AR, ES, FR, RU, ZH
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Wade Robson has everything to lose: his career in Hollywood, his family, friends he has had in the industry since he was a child. He is opening himself up to criticism, accusations of “greed” and an onslaught of hate mail from Michael Jackson fans worldwide (and he will get it, because they have come after me with THOUSANDS of emails in the past). Robson has realized that the truth is far more important: He was molested by Michael Jackson, and he will no longer live in silence for the sake of his son. He’s speaking out about a problem that has plagued Hollywood for decades. Remember: Hollywood is the only place where a man like Gore Vidal can get away with calling Roman Polanski’s rape victim a “little hooker”, and where the ”Hollywood elite” such as Martin Scorsese, Woody Allen, Darren Aronofsky, David Lynch, Mike Nichols, Neil Jordan, Diane von Furstenberg, and Harvey Weinstein can rally behind a convicted child-molesting director. Hollywood is also the place where both Corey Feldman and Todd Bridges have said that child sex abuse is “rampant” in the industry. Corey Haim’s drug abuse and death has been blamed on sexual abuse he suffered as a Hollywood child star. I had never heard Robson speak before I was asked to be an expert for the Today Show piece with him this morning. I was asked if a victim’s coming forward later (after denying or not understanding abuse) was a common trend. Unfortunately, it is, especially when the abuser is a well-loved figure—a priest, a teacher, or Michael Jackson. Victims are carefully groomed to love their abuser. They are told that the abuse IS love. They defend their abuser. And then one day, everything changes. For Robson, it was the birth of his son. Watching him speak on the show today was heart-wrenching. I felt at times that those were my words coming out of his mouth. Robson was groomed, just like I was and just like thousands of victims across the globe. But now, Robson is strong. He is eloquent. He is speaking his truth. Hopefully, other Hollywood children—children who were scared into silence by the Michael Jackson machine, children who were threatened by their parents to stay silent, children who were just to ashamed to talk about what happened to them, children who stayed silent because they were the “breadwinners” in the family—will open up, come forward and find healing. It’s not about the money. It’s never about the money. It’s about finally getting justice for the small child inside of every adult victim. My only regret is not meeting Robson in person. Hopefully, I will be able to do that. Posted by Joelle Casteix on May 16, 2013
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Give us a chance! Most of U.S. are bilssfully unaware of what's really going on. I'm sure you can reason that our imperialistic government no longer represents the will of the American people. Slowly, many are waking up to these facts. Most of us sane folks, however, are not prepared to fend off a small federal army wielding snipers, tanks and helicopters. It might surprise you to know that there currently is an effort to impeach Cheney: http://www.washingtonpost... Think of what would happen if we only impeached Bush! For decades, the American populous has been brainwashed and mind-controlled. We believe(d) the whitewashed history and rhetoric that was stuffed into our heads. A great majority of us are concerned, compassionate and peaceful individuals. Most of us are apalled by what's going on now but have to relearn our place and responsibility. Change will not happen overnight, but we now have a galvanizing force to unite and represent us in Dr. Ron Paul. Please help us by spreading the word in your country to anyone who you think will listen. The "establishent" will stop at nothing to nullify our efforts, but our statement will be made to the world. Want DP delivered to your inbox daily? Subscribe here: Content of posts and comments on the Daily Paul represent the opinions of the original posters, and are not endorsed, approved, or otherwise representative of the opinions of the Daily
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You can help spread fibro awareness by sharing your own articles about fibro here. Fibro bloggers is me and you and real people with fibro talking about fibro and it's related conditions. We can increase fibro awareness through our blogging communities and therefore, the world. One way we can do this by sharing our posts here for more people to see. You share your post here and we get it to a wider audience.
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Supporting potential victims “Enough with evading the issue, LMU. Be transparent. Tell us the facts. Hopefully, even with this information, no one at LMU during [Brother William J.] Farrington [S.J.]’s time at the University will come forward. But, with the unfortunate chance that that is not the case, give them the opportunity to tell their story. Reporting abuse takes innumerable levels of strength. Show that you care. Extend your hand.” hose words formed the conclusion of the Loyolan’s board editorial just 10 days ago (“Enough with evading the issue, LMU,” Sept. 17, 2012), urging the University to take action in the wake of the allegations of sexual abuse against former LMU employee Farrington at his previous schools, Bellarmine College Preparatory and Jesuit High School (as reported in the Sept. 17 Loyolan article “Jesuit accused of sexual molestation spent 15 years working at LMU”). On Tuesday, President David W. Burcham extended that hand in two separate letters: one to the current LMU community (reprinted below) and one to alumni who attended LMU from 1987-2002, when Farrington worked here.
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Johnny Manziel is still livin' the dream -- hitting the Hollywood club scene ... AGAIN ... after a day of partying like a champion. We know Manziel got off to an early start on Sunday -- kickin' his night off at a bar in Hermosa Beach. But after that, Manziel moved the party to West Hollywood ... where the Heisman winner and a bunch of his friends rolled into Greystone Manor nightclub like he owned the place. We're told Johnny Football had a blast inside the club -- and at one point, he threw up the ol' "Hook 'em Horns" sign. Eventually, Manziel and his party crew left the place ... but unlike last time, he wasn't flanked by two smokin' hot chicks. Hey, can't win 'em all. Partying Like a #1 Draft Pick 2/17/2014 7:29 AM PST BY TMZ STAFF Get TMZ Breaking News alerts to your inbox
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Zeppole (or zeppoli in southern dialects), also called sfinge or St. Joseph’s Day cakes, are a traditional Italian pastry. Zeppole are traditionally consumed on March 19 on Saint Joseph’s Day (La Festa di San Giuseppe). In Rome, Naples, Sicily and on the island of Malta, these little pastries are sold on many streets and are sometimes gifts on this day. Zeppole (Italian Doughnuts) Recipe 1 tablespoon vanilla 1 1/2 cups all-purpose flour 1 (15 ounce) container ricotta cheese 2 tablespoons baking powder 1/2 teaspoon salt 1/2 cup granulated sugar cooking oil (for frying) sifted powdered sugar or granulated sugar or cinnamon-sugar mixture In a large bowl beat ricotta cheese with an electric mixer on medium speed until smooth. Add eggs and vanilla; beat until combined. Add flour, granualted sugar, baking powder, and salt & beat on low speed until just combined. Let batter stand 30 minutes. Drop batter by well-rounded teaspoons, four or five at a time, into deep hot fat (365 degree F). and cook 2 1/2 to 3 minutes or until golden brown turning once. Remove doughnuts with slotted spoon and drain on paper towels. Repeat with remaining batter. Cool completely. Shake doughnuts in a bag with powdered sugar, granulated sugar, or cinnamon/sugar mixture. Makes 3 dozen. Photo credit: Barbara L. Hanson
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Celebrate Mexico with Veronica Robles | December 11 Celebrate Mexico with Veronica Robles, Wednesday, December 11, 2013, 3 – 4pm at the Adams Street Branch of the Boston Public Library, (690 Adams Street Dorchester) Veronica Robles is a performer widely recognized as the most authentic representative of Mexican music and culture in New England. Known affectionately by fans as La Mera, Mera (The Real One), Veronica Robles will present a workshop for children to experience the Mexican culture through traditional dance, song and costume. For children ages 6 and up. Space is limited; please register with the children’s librarian, by calling 617-436-6900. This Out-of-school Time program is sponsored by the Boston Public Library Foundation. This event is free and is open to the public. For more information on the details of the event visit:
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At least 80 people were killed and 102 others injured when a tanker truck, carrying fuel, caught fire on Zahedan-Bam road in the southeastern Zahedan, Sistan and Balouchestan province and engulfed 6 passenger buses and another tanker in fire Thursday night, IRNA reported. Head of Zahedan Medical University Mohammad Taqi Hosseini Tabatabaei said those injured were taken to hospitals in Zahedan. Governor General of Zahedan Heidar Ali-Nouraei has earlier told IRNA a tanker, carrying gas oil which collided with another tanker, carrying tar and exploded, and destroyed six buses, a building and a light post near police station. Deputy provincial police head Mohammad Arab said police have launched an investigation to establish the cause of the accident. (Albawaba.com) © 2004 Al Bawaba (www.albawaba.com )
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If Your Dog Poops Please Scoop sign available in 3 sizes #ND-18 If Your Dog Poops Please Scoop is constructed on sturdy aluminum. The sign will be mounted for you. All you'll need to do is place it in the ground. Send all comments and questions
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With spring rapidly approaching, I fear I shall be doing battle with the greatest adversaries of the unsuspecting exchange student, ice and giant puddles of slush. For a northern country, the Estonians do a remarkable job of keeping the roads clear of snow and ice. The same sadly cannot be said about the sidewalks. Each journey out of Raatuse is an adventure, having to pick your way around the big puddles, the known icy patches and mothers pulling small children in little plastic sleds that are abundant on the way to class, to the grocery store, to the popular student haunts, etc. Despite my best efforts, particularly during a warm spell in January and one in early February, I have fallen prey to the ice several times, luckily avoiding the giant puddles of slush (though I can feel it coming) though there have been far too many close calls to count. When falling, there are two ways to go about it. First, you can fall, get up quickly and sort of run away in hopes no one saw you, the path exchange students are apt to take. Alternatively, you can accept that it is inevitable and upon falling, quietly mutter to yourself about how annoying the ice is but just move on, as it happens to everyone, therefore no one cares. Thankfully, there is still time before this battle begins, though I fear no amount of training (not really sure how to train for it but… meh) will allow me to successfully navigate the streets of Tartu unscathed this spring.
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Via BBC News: Comedian Stephen Fry has said he is “prepared to go to prison” over the “Twitter joke” trial. Fry was at a benefit gig for a man who is appealing against his conviction for sending a menacing communication. Paul Chambers had tweeted: “Crap! Robin Hood Airport is closed. You’ve got a week… otherwise I’m blowing the airport sky high!” Fry argued that Chambers’ tweet was an example of Britain’s tradition of self-deprecating humour and banter. Chambers’ case has become a cause celebre on Twitter, with hundreds of people reposting his original comments in protest at the conviction. “This [verdict] must not be allowed to stand in law,” Fry said, adding that he would continue to repeat Chambers’ message and face prison “if that’s what it takes”. Read More: BBC News
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Apps & Games iPhone Quality Index 27 Jan 2015 Showing apps from this publisher for Awaiting 2 Qi-rated apps On The Web: Latest features on LearnVest 03 Dec 2012 Qi finest apps publishers of November 2012 Most critically acclaimed apps publishers on the iPhone Quality Index this month More News >> More Features >> WHAT IS THE QUALITY INDEX? Condensing critical opinion from the best websites into one definitive score All the right links to get in touch with the Quality Index team. Only the best sites feature on the Quality Index - does yours deserve to join them? Keep tabs on the latest news, scores, and entries in the Quality Index. SYNDICATION & DATA Looking for independent critical data? Find out how you can start using the Qi on your portal. ADVERTISE WITH US Give your apps a little extra promotion with the biggest independent iPhone Advertising Network. Other Steel Media sites:
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Eighteen months ago, Baltimore post-punk heroes Double Dagger played its final show at the Ottobar. But the trio of Nolen Strals, Denny Bowen and Bruce Willen aren't finished celebrating the band's career. On April 20 — internationally known as Record Store Day, which falls on the third Saturday in April each year — Double Dagger will host a free record release party at Hampden's Atomic Books. The trio is releasing its final album, a hard-hitting EP called "333," along with a documentary called "If We Shout Loud Enough" that follows the band on its final tour. The film is also part of the 2013 Maryland Film Festival movie lineup. The release/listening party is from 7 to 9 p.m., and all three members will be in attendance. Strals, Bowen and Willen are creating a fanzine for the party that will consist mainly of tour stories. They'll read from the fanzine and tell other stories that night, as well. The fanzine will be exclusive to Atomic Books and its record store Celebrated Summer. You can listen to the final song on "333," "Heretic's Hymn," here. The tour documentary, directed by Gabriel DeLoach, features interviews with Dan Deacon, Wye Oak, Future Islands, Thank You and more. The trailer can be seen here or at the bottom of this post. Pardon the scrolling.
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1st Sgt. Clark Kuhling (left), tells Sgt. Jeramiah Carnie about a life-and-death situation where his dog, Holly-Eva, required blood due to severe illness.While Holly-Eva managed to recover without a human blood transfusion, Kuhling has made it his personal mission to sponsor an annual blood drive for everyone in need. Kuhling and Holly-Eva were on hand at the Tony Bass Fitness Center Feb. 13 during Wiesbaden’s most recent blood drive. Spc. Ryan Kim of the Armed Services Blood Program from the Landstuhl Regional Medical Center prepares to take a blood donation from Sgt. Kari Koch, Company A, 24th Military Intelligence Battalion.
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Partial derivatives commute. This is a basic fact about functions of several variables, and anyone who's studied them knows it and has seen it proved using a bit of algebra and some limits. But why is it true? Let z = f(x,y) be a function of two variables. In the diagram, a small piece of the x,y plane is shown. I've assumed f(0,0) is zero to keep the algebra simple. The proof is contained in the diagram, and can be understood just by looking at it. The following discussion is intended to help with understanding the details of the diagram, but doesn't really add As we move to the right by δx, the value of f, shown on the red line, goes up by If we then move to the rear by δy, the value of f increases by we arrive at the blue dot, labeled The difference between the blue dot and f(δx, δy) in that case is due to the difference between the actual partial of f with respect to y at (δx,0) and the value we used, which was the partial of f with respect to y at (0,0). This difference is On the other hand, if we go around the box the other way, then the function first increases by move to the rear, and then by approximately move to the right. Again, we arrive at the blue dot: And again, the actual value of f(δx,δy) will be different from the blue dot -- but this time the difference will be due to the change in the partial of f with respect to x rather than y. The partial of f with respect to x at (0,δy) will be different from its value at (0,0), and the difference in the value of f will be But the value of f(δx,δy) must be the same no matter how we get there, so the second partials must be the same, no matter which order we evaluate them in. As with most "proof-by-picture" demonstrations, the point of this is not rigor, but rather to show intuitively what's going on. We've ignored a number of details here, such as the difference between the second derivatives at the rear corner and the front corner. To produce a rigorous proof of this requires explicitly evaluating the limits used to define the derivatives to be sure that nothing we ignored made a difference, and the algebra gets a bit messy. But any standard calculus text should include a full proof of this.
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To: Red Badger Looks like a ducted fan, not a jet. posted on 10/04/2010 8:19:08 AM PDT (Gunga galunga. Gunga, gunga galunga) To the average person, it’s a jet............. posted on 10/04/2010 8:28:38 AM PDT by Red Badger (No, Obama's not the Antichrist. But he does have him in his MY FAVES.............) Yah... but “ducted-fan-pack” just doesn’t sound right. :-) posted on 10/04/2010 8:53:40 AM PDT (Personally, I give us... one chance in three. More tea?) FreeRepublic.com is powered by software copyright 2000-2008 John Robinson
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Monday, May 23rd, 2011 Photo by Gary R. Rasberry St. Henry's Brad Heitkamp stretches to catch the ball at first base for an out during Saturday's Division III district final against Lima Central Catholic. Online story associated with this photograph LIMA - For the second straight day, clutch plays were in abundance for the St. Henry Redskins' baseball team. A five-run fifth inning gave the Redskins a lead on Lima Central Catholic, and a defensive gem by Nathan Uhlenhake pr . . . Additional pictures for this date
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LIBERTY - Assistant Liberty Police Chief Eric Todd Rampey has been suspended with pay, according to Police Chief Leland Miller, after Mr. Rampey was arrested Thursday and charged with shoplifting with a value of less than $1,000. According to a spokeswoman for the South Carolina law Enforcement Division, which was asked by the Central Police Department to help investigate the incident at the Wal-Mart in Central, Mr. Rampey, 38, of 118 Duncan Road in Easley, was arrested at noon Thursday and released on bond. "We are an assisting agency," said Kathryn Richardson with SLED. The 13th Circuit Solicitor's Office will handle the prosecution of the case, she said. Chief Miller said the incident is a big blow to his department, which consists of eight uniformed officers, not including the chief and assistant chief. "We've suspended officers before for various discipline incidents, but this is the first involving a criminal case," Chief Miller said. "We will continue to do our jobs and serve the people of Liberty." According to an incident report from the Central Police Department, Mr. Rampey was at the Central Wal-Mart on Jan. 2 around 5:30 p.m. when he was stopped by store employees and later questioned by Central police officer Derek Loftis. According to the report, Mr. Rampey purchased a DVD and placed it a shopping cart, but went back into the store placed a flat screen television, a ceiling fan, an electric fan, two tooth brushes,an electric razor and other items in the cart and proceeded past the store's cash registers. A review of the store's video recorders and Officer Loftis' report were turned over to SLED investigator Khristy Crawford. The report indicated that Mr. Rampey claimed to have paid for the items with two $250 gift certificates at cash registers in the store. Mr. Rampey had a receipt of purchase only for the DVD, according to the report. The report also indicates that items worth a total of roughly $858 were taken. Need Help? Call us at 1-864-260-1284. Monday-Friday: 6am-4:30pm / Saturday: 7am-11am / Sunday: 7am-2pm
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The first came in 1993 when the Paly boys' basketball team took on SoCal power Morningside in a CIF Division III finale in Oakland. Morningside had a dozen coaches and tons of talent while the Vikings had one coach, were undersized but played as a team. The final result? Palo Alto 79, Morningside 59. The second came in 2006 when the boys' basketball team went up against powerful Mater Dei in the CIF Division II state finals. The Monarchs were huge and heavy favorites while the Vikings were again undersized and huge underdogs. Nonetheless, Palo Alto won 51-47. And just two weekends ago, the Palo Alto girls' volleyball team went up against a Long Beach Poly team that was ranked as high as No. 1 in the nation in one poll and a legitimate No. 7 in another. The Jackrabbits were heavy favorites while the Vikings carried the underdog role once again. Against all odds, Palo Alto won. That brings us to Friday night's CIF State Football Bowl Championship Series, where Palo Alto (13-0) will take on Centennial of Corona (14-0) for the Division I title at the Home Depot Center in Carson at 7:30 p.m. It will be yet another David vs. Goliath matchup with the Vikings wielding the slingshot and the Huskies a cannon. "Who gave us chance against Mater Dei in basketball?" asked Paly head football coach Earl Hansen. "They're all high school kids. Yes, they may fill out their uniforms a little more but we've played big teams before. We know what they will do. There are no surprises. "If we do what we have to do, we'll be fine." A glut of eye-popping comparisons in favor of the Huskies, of course, says otherwise. Centennial is ranked No. 2 in the state and No. 5 in the nation, according to MaxPreps, and is averaging a gaudy 54.8 points a game. Palo Alto is ranked No. 11 in the state and No. 72 in the nation while averaging 31.7 points an outing. Centennial has surpassed 60 points four times this season, topped by an 82-21 victory over Corona. Palo Alto has scored 35 or more points six times this season, topped by a 49-14 win over Gunn. No team has scored more than 23 points on Centennial in 2010 while Palo Alto allowed no more than 20 points and that was only once. Barrinton Collins leads Centennial in rushing with 2,325 yards on 224 carries. Dre Hill paces the Vikings on the ground with 923 yards on 131 hauls. Centennial's 6-foot-5 senior quarterback Michael Eubank has completed 155 of 225 passes (.689 percent) for 2,720 yards and 22 touchdowns. He also has rushed 120 times for 1,165 yards. Palo Alto's 6-2 senior QB Christoph Bono has completed 152 of 228 passes (.667 percent) for 2,467 yards and 28 scores. He has rushed for a minus-47 yards on 68 attempts. Centennial has three 1,000-yard rushers, an offense similar to the one unbeaten Oregon runs and statistics that would make any NFL offensive coordinator drool. Palo Alto, meanwhile, has to hope its talented senior tandem of wideouts/cornerbacks Maurice Williams and Davante Adams will make a difference. The two make up the first line of offense and the last line of defense. Both are fast and elusive, have great leaping ability and are dangerous once they get their hands on the ball. On defense, the fact Paly is allowing only 9.3 points a game pretty much says it all to what Williams and Adams (and their teammates) can do. Neither Williams nor Adams are intimidated by Centennial's gaudy stats or scary talent. "It doesn't matter about the team we play," Williams said. "We'll treat them like any other team. We're just as fast. I think we're really prepared for them. If our defense can slow them down a little bit, we have a chance." Williams and Adams will play crucial roles simply because they have so many of them. They play on both sides of the ball and can return punts and kickoffs. Williams has rushed 18 times for 202 yards (11.22 yards per carry) and caught 25 passes for 699 yards (27.96 per catch) with 10 touchdowns. Adams leads the team with 59 catches for 1,036 yards and 10 touchdowns. Williams also has two interception returns for 50 yards. "One of us has to have a big game," said Williams. "They can't cover both of us at the same time." Valley Christian tried to double- and triple-team Adams in the Central Coast Section Open Division finals two weeks ago. Williams responded to the single coverage with four catches for 130 yards and two touchdowns. When Milpitas tried to double and triple Williams, Adams caught seven passes for a career-high 184 yards and two TDs. Adams, for one, is not scared off after seeing Centennial's gaudy stats. "I'm not scared, but they do have my respect," he said. "They have an offense and we have a defense. And they're not going to stop our offense. We have people who step up in big-time situations." It was believed that Palo Alto couldn't get past the West Catholic Athletic League triumvirate of Mitty, Bellarmine and Valley Christian and keep its unbeaten season alive. Yet, the Vikings outscored the three by 69-24 to set an all-time school record for most single-season football victories. Palo Alto has played football for 99 years and this is the first team to go 13-0. It will take something special, however, to make it a 14-0 year. Palo Alto also goes in with a combined 599 victories for rugby and football. "Everybody has to have their best games," Adams said. "We don't have room for error." Hansen echoed that sentiment. "We've got to tackle. We've got to get first downs. We can't make mistakes and give them a short field," he said. Hansen and some of his coaches attended Centennial's 45-21 win over Vista (Murrieta) in the CIF Southern Section playoff finals. "Vista was up 10-7 with about two minutes left in the half," Hansen said. "It was 21-10 before you knew it; 14 points in no time. They (Centennial) can do that to you." Hansen said it will be important to keep the game close, heading into the final period. That will serve Centennial notice that Paly intends to make a game of it. "We need to keep them off the field, the best we can," Hansen said. In light of Centennial's offensive similarity to Oregon, Hansen has spoken with Stanford defensive coordinator Vic Fangio and his own son, Peter, a defensive assistant with the Cardinal who also was an assistant coach at Paly in 2006 when the Vikings played in the first-ever state playoffs. "I got some ideas from them (on how to try stopping Centennial)," Hansen said. Paly, in fact, runs the same 4-3 defense that Stanford ran in 2009 when the Cardinal beat Oregon in Stanford Stadium, 51-42. Stanford switched to a 3-4 defense this season and the Ducks ran off with a 52-31 win, the only blemish on Stanford's 11-1 season. "Fangio was funny," Hansen said. "He said they didn't do anything to stop them." Hansen has to hope his team will have a better result against the no-huddle offense, which Centennial runs. Most certainly, the Vikings can't let the Huskies approach their season scoring average unless Centennial can't stop Paly's offense. Bono has the stats, poise and the arm to get it done but will need protection. Junior running backs B.J. Boyd (83 for 728 yards) and Hill also have proven they can do the job. And the receiving corps of Williams, Adams and T.J. Braff is as good as it comes. But, said Adams: "It's not enough to get five-yard plays. We have to make BIG plays. And we have ways to get people the ball." Palo Alto scored early against both Bellarmine and Valley Christian, perhaps shocking both teams that were considered to be favored. The Vikings need to do the same against the Huskies, and perhaps quiet their fans. Centennial, after all, was hoping to play De La Salle in the Open Division state finale after facing the Spartans in that game the previous two seasons. Some fans have blogged that their team needs to score 80 points on Palo Alto to prove to the CIF commission that decided the matchups that a mistake had been made. "They can say whatever they want to say," said Williams. "We'll see at the end of the game." Yes, the Vikings are confident. "Everyone knows a state championship is on the line," Adams said. "Being 14-0, that's the mindset going in — making history."
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Search America's historic newspaper pages from 1836-1922 or use the U.S. Newspaper Directory to find information about American newspapers published between 1690-present. Chronicling America is sponsored jointly by the National Endowment for the Humanities external link and the Library of Congress. Learn more About The pilot. (Nashville, Tenn.) 189?-1897 Nashville, Tenn. (189?-1897) The pilot. : (Nashville, Tenn.) 189?-1897 - Place of publication: - Nashville, Tenn. - Geographic coverage: | View more titles from this: - Pilot Pub. Co. - Dates of publication: -v. 4, no. 4 (Jan. 28, 1897). - Davidson County (Tenn.)--Newspapers. - Nashville, Tenn. (Tenn.)--Newspapers. - Description based on: V. 3, no. 1. (Jan. 2, 1896). - Editor: -Jan. 28, 1897, Jas. A. Tate. - sn 96091054 - Succeeding Titles: View complete holdings information
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For many discrete planning problems that we would like a computer to solve, the state space is enormous (e.g., states). Therefore, substantial effort has been invested in constructing implicit encodings of problems in hopes that the entire state space does not have to be explored by the algorithm to solve the problem. This will be a recurring theme throughout this book; therefore, it is important to pay close attention to representations. Many planning problems can appear trivial once everything has been explicitly given. Logic-based representations have been popular for constructing such implicit representations of discrete planning. One historical reason is that such representations were the basis of the majority of artificial intelligence research during the 1950s-1980s. Another reason is that they have been useful for representing certain kinds of planning problems very compactly. It may be helpful to think of these representations as compression schemes. A string such as 010101010101... may compress very nicely, but it is impossible to substantially compress a random string of bits. Similar principles are true for discrete planning. Some problems contain a kind of regularity that enables them to be expressed compactly, whereas for others it may be impossible to find such representations. This is why there has been a variety of representation logics proposed through decades of planning research. Another reason for using logic-based representations is that many discrete planning algorithms are implemented in large software systems. At some point, when these systems solve a problem, they must provide the complete plan to a user, who may not care about the internals of planning. Logic-based representations have seemed convenient for producing output that logically explains the steps involved to arrive at some goal. Other possibilities may exist, but logic has been a first choice due to its historical popularity. In spite of these advantages, one shortcoming with logic-based representations is that they are difficult to generalize. It is important in many applications to enable concepts such as continuous spaces, unpredictability, sensing uncertainty, and multiple decision makers to be incorporated into planning. This is the main reason why the state-space representation has been used so far: It will be easy to extend and adapt to the problems covered throughout this book. Nevertheless, it is important to study logic-based representations to understand the relationship between the vast majority of discrete planning research and other problems considered in this book, such as motion planning and planning under differential constraints. There are many recurring themes throughout these different kinds of problems, even though historically they have been investigated by separate research communities. Understanding these connections well provides powerful insights into planning issues across all of these areas.
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Renault’s new-look Koleos compact crossover arrives in NZ later this month with fresh styling and an updated equipment list. The Koleos Phase 2 represents the first significant facelift for Renault’s inaugural compact SUV since it was originally launched in late 2008. The Koleos is an important model in the NZ Renault range since the franchise was reinvigorated early this year. “The mix of models – 2WD and 4WD and both petrol and diesel engines has given the market a value for money choice,” said Stephen Kenchington, General Manager of Renault New Zealand. The most popular model in NZ has been the 4WD Koleos with CVT transmission and standard leather upholstery and remains available as a free upgrade for $43,990. Design changes on the Koleos Phase 2 include a revised interior and a new-look front-end that takes styling cues from Renault’s other Korean produced models, the Fluence and Latitude sedans. There’s a more rounded front bumper and all-new bonnet and front quarter panels that wrap around narrower headlights and a more traditional six-sided, three-bar chromed grille. Inside, the Koleos will feature new seat upholsteries and interior trims, while the dashboard has been revised with a more contemporary instrument panel housing and lighting. In terms of powerplants, the upgraded Koleos will continue to be available with a 2.5-litre petrol engine in front-wheel drive and Nissan-developed AWD configurations, as well as the flagship AWD-only 2.0-litre diesel six speed automatic variant. This model tops the Koleos range at $49,990 plus on-road costs, while the most affordable Koleos is the 2.5 2WD CVT priced at $37,990. All three models come standard with six airbags, electronic stability control, ABS brakes, emergency brake assist, seatbelt pre-tensioners and a maximum five-star Euro NCAP safety rating. Other standard features include cruise control, remote central locking with engine immobiliser, Bluetooth, seven function trip computer and, split opening tailgate. The AWD models are upgraded further with automatic lights and windscreen wipers, fog lights, rear parking sensors, satellite navigation, hill start assist, hill descent control and heated door mirrors. The Koleos is sold in 40 countries on five continents and last year more than 70 per cent of sales were in markets outside Europe.
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