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The pharmacokinetics of oral 6-mercaptopurine (6MP) was assessed in 20 children with acute lymphoblastic leukemia during maintenance therapy.
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A patient suffering from a rare enzyme deficiency developed a malignant neuroleptic syndrome after having been treated with one single dose of haloperidol.
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Case report: colonic stricture and fibrosis associated with high-strength pancreatic enzymes in a child with cystic fibrosis.
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We report the displacement of a tunnelled intrathecal catheter causing significant cerebrospinal fluid (CSF) leak, resulting in partial coning and a sixth nerve palsy.
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A fatal case of pancytopenia due to levomepromazine.
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Thereafter the maintenance dose can be small and fluctuations in the illness do not seem to occur.
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Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.
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A 53-year-old male, without any prior history of psychosis, developed schizophrenia 4 days after starting low-dose bromocriptine therapy for a macroprolactinoma.
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Recent chickenpox contact should initiate VZV serologic studies in Reye syndrome patients, regardless of the chickenpox history or evidence of infection with other viruses.
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Patients reported dramatic reduction in itching after cyproheptadine.
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Ulcer became worse after tobramycin and gentamycin treatment for 2 days.
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A new therapeutic regimen is suggested, which includes long-term antibiotics combined with an immediate modification of azathioprine therapy and early graft nephrectomy in selected cases with renal parenchymal involvement.
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We encountered two cases of macular infarction that occurred after vitrectomy performed for mild endophthalmitis, which, on culture, yielded Staphylococcus epidermidis.
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Severe hyperphosphatemia following acute tumor lysis syndrome.
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Four hemodialyses with charcoal hemoperfusion were performed over 72 h.
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Three cycles of chemotherapy had been administered without complications when, at the beginning of the fourth cycle, the patient developed clinical and laboratory abnormalities consistent with the development of the hemolytic-uremic syndrome.
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In high-risk patients with NSTE ACS for whom an early invasive strategy is planned, enoxaparin and UFH are the agents with the highest level of evidence (evidence level A).
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On followup, the patient reported disappearance of symptoms.
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We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor.
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CONCLUSION: This patient's neurological deficits were not due to the epidural analgesia.
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The patient responded to gluten restriction, as shown by resolution of jejunal abnormalities and skin lesions and subsequently by recurrence of jejunal abnormalities and skin lesions with reinstitution of a gluten-containing diet.
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Despite the risk of needle-track seeding, PEI remains useful in the treatment of HCC.
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It is unclear whether this case, similar to other cases of low-grade B-cell lymphoproliferations reported after transplantation, is related to immunosuppression and therefore part of the spectrum of PTLDs, or merely represents coincidental event occurring in an immunocompromised patient.
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Amoebic disease precipitated by corticosteroids prescribed for tuberculous pleural effusions.
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Although this type of hyperpigmentation has been previously seen in patients with cancer who are receiving bleomycin, this is, to our knowledge, the first reported case of bleomycin-induced hyperpigmentation in an AIDS patient and should be added to the growing list of cutaneous eruptions seen in these patients.
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Both patients were heavy imbibers of alcohol and both had swallowed less paracetamol that that generally regarded as a lethal dose.
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Histology of a cutaneous lesion showed spongiosis and infiltration of the epidermis by atypical lymphocytes with large hyperchromatic nuclei, perivascular dermal lymphocytic infiltrate (CD3+) mixed with plasma cells and occasional large immunoblasts (CD20+).
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All the alternative medications for rheumatological patients are significantly more toxic than HCQ.
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Chickenpox in adult renal transplant recipients.
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Microscopic examination showed nests of mature adipocytes expanding toward the dermal reticular layer.
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One of the 3 patients was reexposed to etanercept later on.
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Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.
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Prior sexual profile included from no sexual outlet to hypersexuality.
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CE was confirmed either by renal biopsy (case 1) or skin biopsy (case 2).
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CASE SUMMARY: A 25-year-old postpartum white woman developed multiple watery stools and abdominal cramping on day 6 of therapy with clindamycin vaginal cream for bacterial vaginosis.
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DISCUSSION: On four separate occasions the patient was challenged advertently or inadvertently, with sustained-release verapamil.
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Herpes simplex keratitis in renal transplant recipients.
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Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?
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Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).
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His renal function returned to baseline 14 days later with supportive care, folinic acid rescue, and urinary alkalinization.
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Another four patients went into partial remission, amounting to an overall response rate of 58%.
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We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21.
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Preliminary evidence for inhibitory effect of glycyrrhizin on HIV replication in patients with AIDS.
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Prothrombin complex concentrates (PCCs) and, more recently, activated prothrombin complex concentrates (APCCs), are widely used for the treatment of active bleeding in haemophiliacs with inhibitors.
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A new type of minocycline-induced cutaneous hyperpigmentation.
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It has been associated with phenytoin, cyclosporine, and calcium channel blocking agents.
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An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.
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CONCLUSIONS: Colchicine-induced myopathy should be excluded in patients with FMF who present with generalized muscle weakness.
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The patient was treated surgically by foramen magnum decompression and occipito-cervical fusion, and by transoral resection of the clivus.
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He had also developed elevated serum ammonia levels while on valproic acid.
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Moreover, as the pathophysiology of this disorder becomes less of a hypothesis and more of an understood entity, it is likely that treatment options will broaden beyond the use of daily prophylactic colchicine.
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The course of this case may be useful in the understanding of the pathogenesis of autoimmune hyperthyroidism.
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More recent case reports have concentrated on the use of cardiopulmonary bypass.
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Twelve patients reported improvement in pain and mood, while 11 reported improvement in sleep.
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We report a case of tularemia presenting as a solitary pulmonary nodule following syngeneic PBSC transplant.
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Various combinations of antibiotics have been successful in achieving cure; however, at present, high-dose penicillin (greater than 25 million units/day) in combination with an aminoglycoside for a period of six weeks appears to be the optimum therapy.
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Neurological evaluation of children with ALL at diagnosis and during treatment is of value in order to diagnose neurological complications early so that appropriate intervention can be adopted.
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However, a surgical approach consisting of resection of the colon may sometimes be necessary, even in patients with complete aplasia and a high risk of complications.
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Dosing adjustment in patients with renal dysfunction is not necessary for anastrozole.
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All the data suggested that the antibiotic was responsible for the deterioration in renal function.
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These included advanced age, chronic lung disease, liver disease, and administration of cimetidine.
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This case report describes the unanticipated development of pyometra in Brown Norway rats after treatment with estrogen.
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RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.
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A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.
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Aminoglutethimide was discontinued until completion of radiotherapy, and the rash resolved.
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Magnetic resonance imaging was more useful than computed tomography in the early diagnosis and management of these acute lymphocytic leukemia patients with leukoencephalopathy.
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Computed tomography of the brain was normal but electroencephalography showed focal theta and delta slow waves over the right temporal-parietal-occipital area.
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To our knowledge, this case is the first published report of levofloxacin-induced TEN.
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This is the second report to describe such findings, which are attributed to damage of the inferior division of the third cranial nerve secondary to manipulation of adjacent ethmoid tissues.
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After 15 minutes, amiodarone infusion (25 microg/kg/min) eliminated further paroxysms in both patients, allowing both interventions to be completed safely and effectively.
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Serum potassium values higher than 7 mmol x l-1 are associated with cardiac arrhythmias and an increased incidence of intraventricular haemorrhage and periventricular leucomalacia.
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We describe longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy following methotrexate therapy in a 24-year-old man diagnosed with pre-B-cell acute lymphoblastic leukemia (ALL), presenting with right-sided paralysis and aphasia after second consolidation with intrathecal triple-drug therapy given intrathecally.
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Adhesions to manufacturer's trademark on the surface of a posterior chamber lens.
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Acute coronary vasospasm during thoracic spine surgery.
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This article describes a safe and highly effective augmentation technique in patients suffering from some of the most serious and debilitating forms of anxiety disorders, namely obsessive-compulsive disorder and panic disorder.
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The possible causes included underlying artherosclerosis, the use of pneumatic tourniquet, surgical manipulation, and arterial spasm.
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Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.
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She had taken feedings through a nasogastric tube with 1000 ml (1000 kcal) of Ensureliquid daily since 1993 because of the muscle weakness after rhabdomyolysis.
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Interventional pain management is an evolving field and the standard of care is broadly defined.
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Therefore, contact lens wear should be discontinued to prevent further complications.
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Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA).
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Endoscopic retrograde cholangiopancreatography demonstrated normal biliary tree and pancreatic ducts.
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Bleomycin induced hyperpigmentation with yolk sac tumor.
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These malignancies may represent either a new clonal disorder or a complication of drug treatment.
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Choline magnesium trisalicylate was then administered in an effort to control her fever, and was successful.
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This issue is important, given the increasing use of chemotherapy in combination with radiotherapy.
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Adverse reaction to prednisone in a patient with systemic lupus erythematosus.
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Plasma exchange with either fresh-frozen plasma or 5% albumin solution as replacement fluid was performed in four selected patients with juvenile rheumatoid arthritis unresponsive to standard therapy.
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Angio-oedema as an unusual tolerable side effect of voriconazole therapy.
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A case report.
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The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.
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Association of fluoxetine and return of sexual potency in three elderly men.
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Myocardial ischemia associated with high-dose carmustine infusion.
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RESULTS: Best corrected visual acuity before injection was 6/60 in the left eye.
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New observations, including CT scan findings and experience with treatment by praziquantel.
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Further doses were required as the respiratory depression recurred.
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CONCLUSIONS: We report the association of postoperative chylothorax treated with somatostatin analog (octreotide) and necrotizing enterocolitis in an infant following aortic coarctation repair.
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The brain and spinal cord were examined routinely, and histological sections were taken for evaluation.
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CONCLUSIONS: Anti-TNFalpha antibodies appeared in this case to improve TPN-related cholestasis.
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Charcoal haemoperfusion and cysteamine therapy led to the rapid removal of the paracetamol from the body and consequently prevented the development of severe hepatic necrosis.
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