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Grade IV leucopenia and thrombocytopenia were observed in one of three patients at the 100 mg/m2 dose level.
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In this paper we present a patient with the diagnosis of nephrotic syndrome and a known history of hepatitis C who received IFNalpha therapy for newly diagnosed CML.
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We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to chloramphenicol-associated myelotoxicity.
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Early deaths with thrombolytic therapy for acute myocardial infarction in corticosteroid-dependent rheumatoid arthritis.
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Changing treatment from efavirenz to a protease inhibitor was accompanied by improvements in the desired urinary Histoplasma antigen level and plasma itraconazole concentration.
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Appropriate stains indicated that this had many characteristics of lipofuscin.
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Oseltamivir was well tolerated outside vomiting during the first three days of treatment in one patient.
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The histopathology of the subretinal fibrotic tissue confirmed the diagnosis.
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It would be advisable to measure thiopurine methyltransferase activity before patients with autoimmune hepatitis are exposed to azathioprine.
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Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol.
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Outcome is probably more dependent on the clinical condition of the patient and the reversibility of the drug toxicity.
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RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment.
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The tumor necrosis factor-alpha antagonist (TNF-alpha) etanercept has been approved for the treatment of rheumatoid arthritis, juvenile rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and psoriasis.
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The infiltrate disappeared within 6 weeks.
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Hospital drug therapy included enoxaparin.
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This report demonstrates the increased risk of complicated varicella associated with the use of corticosteroids, even for a short period of time.
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One of these patients showed pyramidal features and subsequently developed an optic neuropathy and pigmentary retinopathy.
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Before recognition of pregnancy, the latter had been treated for acute myelocytic leukaemia receiving cytarabine, daunorubicin and doxorubicin at conception and cytarabine and thioguanine at about 35-37 days post conception.
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A full-term newborn developed oliguric renal failure at 24 hr of life, which persisted for several days.
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Polymyositis masquerading as mitochondrial toxicity.
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He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.
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In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.
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This case demonstrates that there is no cross reactivity between glyburide and chlorpropamide in producing hemolytic anemia.
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The pathogenic mechanisms involved in the development of adriamycin cardiomyopathy are reviewed, and the possible synergistic effect of other antitumor antibiotics is discussed.
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Punctate keratitis with keratinization of the cornea led to complete loss of vision.
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She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.
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A young woman developed galactorrhea during treatment with a new dibenzoxazepine antidepressant, amoxapine.
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Increasing clinical experience with the selective serotonin reuptake inhibitors and tricyclic antidepressants make combination antidepressant therapy at times a reasonable alternative to single-agent therapy in primary care patients with depression.
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Ehrlichiosis, a tickborne illness transmitted by tick vectors Amblyomma americanum and Ixodes scapularis, can be acquired in endemic areas.
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A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.
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Transient acute myopia resulting from isotretinoin (accutane) therapy.
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Interstitial pneumonitis, induced by hormone treatment given for prostate cancer, is a reversible condition and a quick diagnosis followed by prompt, proper treatment is important to ensure a successful recovery.
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It usually occurs in otherwise healthy young adults, often in association with a severe soft tissue infection and has a 30% mortality rate.
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We describe a case of 73-year-old patient who has been operated in emergency on triple coronary artery bypass graft (CABG), which was complicated with respiratory insufficiency and devastating mediastinitis.
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Interaction between antiepileptic and antiretroviral agents is an emergent problem caused by the increasing association of the two therapies.
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Bronchiolitis obliterans organizing pneumonia (BOOP) is a clinicopathologic syndrome with characteristic features.
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An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine.
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We report a case consequent to a surgical operation for cataract.
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Application of the Naranjo probability scale categorized this adverse reaction as being probably due to LMWH.
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It responds well to conventional treatment along with the discontinuance of rifabutin.
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Migraine prevention.
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Patch testing for ethylenediamine was positive.
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Cases illustrating the following concepts are presented.
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We discuss 2 recent cases seen at our institution and 39 cases described in the English-language literature since 1995.
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BACKGROUND: Fluticasone propionate was introduced in 1993 in the UK as a potentially safer inhaled corticosteroid than those already in use.
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In fact, this error has taken place a number of times in North America in the preceding decade.
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The diagnosis of disseminated Zygomycosis was made four days after onset of clinical symptoms.
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Protamine sulphate 50 mg was given i.v., resulting in cessation of bleeding and normalization of the thrombelastogram and KCT.
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Throughout hospitalization the patient underwent aggressive diuresis.
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Avascular necrosis of bone: the hidden risk of glucocorticoids used as antiemetics in cancer chemotherapy.
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The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.
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A selective association between fluoxetine and extensive, prominent eye movements in nonrapid eye movement (NREM) sleep was detected, utilizing Fisher's exact one-tailed statistic (p less than 0.00001 for each comparison).
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HNCPs with malignant disease require judicious dental treatment planning prior to radiation therapy (RT) and/or chemotherapy.
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These lesions were attributed to treatment and recurred soon after a rechallenge with omeprazole.
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METHODS: A retrospective review of 136 central line (Broviacs [B], Port-A- Caths [PC] and Hickmans [HC]) removals during the last 5 years was undertaken.
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Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.
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OBJECTIVE: To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.
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OBJECTIVE: To demonstrate the potential value of obtaining routine fungal cultures of donor rims at the time of corneal transplantation and instituting prophylactic therapy in culture-positive cases, even in the absence of clinical evidence of established microbial keratitis or endophthalmitis.
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The liver also showed peliosis hepatis.
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After 20 months of therapy on etanercept, his plaque psoriasis markedly improved, whereas both his fasting blood sugars and glycosylated hemoglobin A(1c) decreased.
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Seven of the twelve were treated with beta blockers; 3 of whom suffered cardiac arrest.
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All received tissue plasminogen activator.
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The scleritis completely resolved after initiation of systemic corticosteroids.
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All patients received base-line immunosuppressive therapy with one or more of the following drugs: cyclosporine, corticosteroids and azathioprine.
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The induction of hypoglycaemia with PAS in this patient suggests a potential role for PAS in the treatment of diabetes mellitus.
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Despite continued improvements in mortality associated with a spinal-cord injury, until recently little progress had been made in improving neurologic function.
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Case 3: A 29-year-old female alcoholic complained of general fatigue and a slight fever after 1.5 years of abstinence with cyanamide treatment.
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Sensory neuropathy revealing necrotizing vasculitis during infliximab therapy for rheumatoid arthritis.
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CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.
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During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.
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Symptoms of major depression: acute effect of withdrawing antidepressants.
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Ampicillin-induced interstitial nephritis with generalised exfoliative dermatitis.
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Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.
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Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.
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We present the course of illness of a 56 year-old patient with acute gastrointestinal bleeding after penetration of an aneurysm of the hepatic artery in the duodenal bulb.
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We describe the clinical course of an EBV seronegative 11-yr-old boy who underwent double lung transplantation and subsequently developed PTLD in the graft.
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Dissolution of pancreatic stones by oral trimethadione in patients with chronic calcific pancreatitis.
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Enalapril-induced anemia in two kidney transplant recipients.
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All 24 of them received mecamylamine in 2.5-6.25 mgm/day dose, at varying starting dates during the years June 1997 to June 1999.
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Cutaneous bacterial infections, most commonly caused by Pseudomonas aeruginosa, have been clearly linked to use of hot tubs.
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A 37-year-old male ingested 12 gm of fluoxetine approximately 2 hours prior to arrival at an emergency department.
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Posterior tibial tendon rupture in a world class runner.
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Early diagnosis of WE is important, because if it is treated with thiamine in the acute stages, the neurologic and cardiovascular abnormalities can be reversed.
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The catheter was removed after 14 days because a local infection developed that resolved uneventfully with antibiotic therapy.
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Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.
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Chemotherapy was held.
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Diagnosis may be confirmed by CT-scanning of the orbits.
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However, the implication of TMP/SMX inducing aseptic meningitis has been underreported to FDA/MEDWATCH program.
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The patient had a history of four resections since the age of 19 years.
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The institution of lithium treatment in 1964 caused a dramatic improvement in the patient's condition.
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Thirteen parkinsonian patients drawn from two large parkinsonism clinics experienced hypersexuality as a consequence of anti-parkinsonian therapy.
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However, glucose-phosphate dehydrogenase was normal in the present case, suggesting that it is not a predisposing condition to the lung injury.
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Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.
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CASE REPORTS: Serial clinical examination of three patients was performed.
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Chryseobacterium indologenes is a non-fermentative Gram-negative bacillus that is a rare pathogen in humans.
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Encephalopathy and death may occur.
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In this report, two patients with advanced rheumatoid arthritis, who were safely and effectively treated with dapsone after failure with other second-line agents, are described and the literature is reviewed.
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People who become dependent on these mixtures commonly do not present for medical assistance until the problem is severe.
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We report a case of myoclonus induced by quetiapine.
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Long-term clinical and pharmacokinetic studies will be required to determine whether or not niflumic acid can be employed in the prevention or treatment of both of apparently idiopathic osteoporosis or corticosteroid-induced osteoporosis.
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