async def METHOD_NAME(self, app, message):
    handler = MessageHandler(filters.Regex("one") & filters.Regex("two"), self.callback_regex2)
    app.add_handler(handler)
    async with app:
        message.text = "not it"
        await app.process_update(Update(0, message))
        assert not self.test_flag
        message.text += " one two now it is"
        await app.process_update(Update(0, message))
        assert self.test_flag