diff --git a/requirements.txt b/requirements.txt
index <HASH>..<HASH> 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -3,5 +3,4 @@ scipy>=0.16.0
 matplotlib>=1.4.3
 biopython>=1.65
 pandas>=0.17.0
-rpy2>=2.8.0
 seaborn>=0.7.0
diff --git a/setup.py b/setup.py
index <HASH>..<HASH> 100644
--- a/setup.py
+++ b/setup.py
@@ -48,7 +48,6 @@ setup(
     install_requires=['biopython',
                       'matplotlib',
                       'pandas',
-                      'rpy2',
                       'scipy',
                       'seaborn'],
     classifiers=[
diff --git a/tests/test_dependencies.py b/tests/test_dependencies.py
index <HASH>..<HASH> 100644
--- a/tests/test_dependencies.py
+++ b/tests/test_dependencies.py
@@ -29,12 +29,7 @@ def test_dependency_numpy():
 
 def test_dependency_pandas():
     """Test pandas import."""
-    import rpy2
-
-
-def test_dependency_rpy2():
-    """Test rpy2 import."""
-    import rpy2
+    import pandas
 
 
 def test_dependency_scipy():
remove requirement for rpy2