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Old Newark is the main site for the Old Newark Web Sites. The other sites are accessable from the menu on the left. For further information on Old Newark please click on "About" in the menu at the immediate left. The far left menu contains the most important links on the site. "Main Menu" will bring you back to this page.
In addition to my own research, Old Newark relies on user submissions. If you have memories, information, photos or any other item that you would like to see on Old Newark please email me.
Click here to read Award Winning Author Martin Bucco's Newark memory - "Hunterdon Street, 1939". | {
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Ginsburg Misses Supreme Court Arguments For First Time After Cancer Surgery
By Nina Totenberg
Domenico Montanaro
Published January 7, 2019 at 8:51 AM CST
Associate Justice Ruth Bader Ginsburg poses for the official photo at the Supreme Court in Washington, D.C., on Nov. 30, 2018.
Supreme Court Justice Ruth Bader Ginsburg is not taking part in Monday's oral arguments before the court.
The 85-year old liberal justice underwent surgery for cancer last month and also recently broke several ribs after a fall.
Ginsburg had not missed a day of arguments since she was confirmed to the court in 1993.
Despite not physically being at the court, she will be participating in the cases by reading the briefs and the transcripts of the oral arguments.
Ginsburg had hoped to be back on the court for arguments, but Dr. Douglas Mathisen, chairman of thoracic surgery at Massachusetts General Hospital, warned that getting back to work too quickly after this kind of surgery could mean "one step forward and five steps back."
Ginsburg is expected to make a full recovery and be back on the court.
"These days we are seeing more and more patients in their 70s and 80s make relatively quick recoveries," Mathisen said last month before Ginsburg's surgery, "because we are detecting so many more lung cancers at early stages" when treatment is far more effective and successful.
This is Ginsburg's third bout with cancer. In 1999, she was treated for colorectal cancer; a decade later, she was treated for pancreatic cancer.
Ginsburg is one of four ideologically liberal justices on the court. President Trump has shifted the court in a more conservative direction, appointing two Supreme Court justices — Neil Gorsuch and Brett Kavanaugh. Kavanaugh replaced the court's swing justice, Anthony Kennedy, for whom he clerked.
The court this term has deliberately avoided politics in the cases it is hearing, under the leadership of Chief Justice John Roberts, but the prospect of Trump appointing a third justice has liberals very nervous, especially as the 2020 elections approach.
Ginsburg has become a cultural icon for the left, with the nickname "The Notorious RBG" getting attached to her for her sharp dissents, and in the past year, there have been at least two widely distributed motion pictures memorializing her life — the RBG documentary, which premiered at Sundance last year, and On the Basis of Sex, which is out in theaters now. Ginsburg is played by Felicity Jones.
Ruth Bader GinsburgU.S. Supreme Court
Nina Totenberg
Nina Totenberg is NPR's award-winning legal affairs correspondent. Her reports air regularly on NPR's critically acclaimed newsmagazines All Things Considered, Morning Edition, and Weekend Edition.
See stories by Nina Totenberg
Domenico Montanaro is NPR's senior political editor/correspondent. Based in Washington, D.C., his work appears on air and online delivering analysis of the political climate in Washington and campaigns. He also helps edit political coverage.
See stories by Domenico Montanaro
Armed Activists Demonstrate Outside Texas Capitol To 'Stand Up For Individual Rights'
In His Inaugural Address, Biden Seeks To Move Past 'American Carnage'
Police Arrest Man With Handgun, Woman Impersonating Officer Near D.C. Checkpoints
No, Ruth Bader Ginsburg Does Not Intend To Retire Anytime Soon
"I will retire when it's time," the 83-year-old Supreme Court justice said in an interview with NPR. She also shares wedding advice from her mother-in-law and reads a letter from her late husband. | {
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I still can't believe that 2016 is over! There were so many new releases that I didn't get a chance to read in 2016, so this week's topic was easy: "Top Ten 2016 Releases I Meant To Read But Didn't Get To (But TOTALLY plan to)." I had no problem filling this list! Here are my top ten 2016 reads still on my TBR list, in no particular order. Covers link to Amazon (affiliate) or Goodreads.
Empire of Storms by Sarah J. Maas: I cannot believe that I haven't read this book yet! I own it in hardback, ebook, and audio…I have no excuse! It's one of the first books on my list to knock off my TBR pile. I'm dying to know what will happen now that Aelin is home, Rowan is with her, and magic is back in the lands.
The Shadow Hour by Melissa Grey: I loved the first book in this series SO much. It consumed me when I was reading it. I grabbed a copy of this book as soon as it was released because I need to know what will happen next in this world, but then other matters like moving got in the way of me actually reading it and I found myself looking at it on the shelf instead of actually reading it.
Frost Like Night by Sara Raasch: I'm equal parts excited and terrified to read this book. I was not a fan of Ice Like Fire. It was too much of a bridge book IMO and really if it wasn't for the way it ended I wouldn't even want to read this one. BUT I love the characters and I love the world Raasch created so I'm excited to see the conclusion to the series. I'm hoping it wraps up well but I'm a little nervous to read it.
Riders by Veronica Rossi: I loved Under the Never Sky by this author! I've read it more than a couple of times and now as I type this I'm thinking it's time for another reread. So when I heard in 2015 that she was writing a new series I was excited. I bought the book when it was released, but somehow I forgot about it *hangs head in shame* It's on my TBR now and I plan to read it ASAP.
The Impostor Queen by Sarah Fine: Sarah Fine is one of my favorite authors. I've read all of her books to date, except this one. I'm not sure why I haven't read it yet. It's high fantasy which I love so I've added it to this year's TBR and I'm hoping to read it soon.
A Million Worlds with You by Claudia Gray: After the ending of Ten Thousand Skies Above You, I was distraught. Not only do I love these characters and the world Gray has created, I had to wait a whole year for the conclusion. Now that this book is out, I've dreaded reading it. Not because I don't want to read it, on the contrary I do. I just don't want the story to end. I need to know what has happened to Theo, Paul and Meg, but I don't want their story to come to an end. I will read it, and I will read it soon because I NEED to know what's happened, but I will be sad to do so.
The Midnight Star by Marie Lu: I have purposely put off this book. I love Adelina. She is such a tortured character that has fallen so far and has become so twisted. She is truly going to be a magnificent villain. I'm a little scared to read it. I've heard it's dark and so I've been mentally preparing myself. I will read this one soon. I have it on hold at the library, I just need to work up the nerve.
And I Darken by Kiersten White: I've been excited for this book for a long time. I even have an ARC of it lying around somewhere. The problem is it was released the week I moved this Summer so I forgot about it. I'm ashamed to admit that but I figured it's better to speak honestly than make up some excuse. I'm hoping to knock it off my list soon, as in within the next month. Mainly because I want to read the sequel!
Ivory and Bone by Julie Eshbaugh: Another book I have an ARC of that I missed because of moving. I've heard mixed reviews of this book, but I'm still excited to read it. I believe it is a prehistoric retelling of Pride & Prejudice. Props to the author for creativity on that one!
I intend to read Empire of Storms at some point this year too! I can't believe that I didn't get around to it last year.
I really liked And I Darken but haven't read any of the others yet! Reading time is so precious, I wish I could stretch time!
I really enjoyed And I Darken! I hope you get to read it soon.
Riders is on my list too. But DROP EVERYTHING AND READ EMPIRE OF STORMS NOW! 🙂 Hope you enjoy all of these! Have a great week!
Oohh, they aren't on my list, but I want to read And I Darken and Bright Smoke, Cold Fire, too.
I'd hoped to read Riders in 2016 as well, but I never got a chance. That cover is so stunning!
I hope you enjoy these when you're able to get to them!
Ivory and Bone was pretty good. I hope that you get to all of these in 2017.
I don't keep up well with release dates, but if I had my NetGalley self together I could have done this post this week. Oh well. I need to be reading them anyways!
And I Darken was on my list this week too. I really enjoyed Empire of Storms when I read it, so I hope you do too!
Ooh nice! I'm behind on a lot of my triologies! I was holding off reading all the book 2s since they were all pretty much cliffhangery and then when the book 3s came out I didn't have time to get to them! Going to try to not accept as many review books this year, I felt like every other book I read last year was a review one! Lol. But they were always ones I WANTED to read as well, so it was hard to say no too! Haha! Hope you get to read all of these this year!
Great list! I hope you are able to get to some if not all of these this year.
I keep kicking myself for not reading Replica and Heartless when I wanted them so bad. I am determined to read them this year! | {
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The request will be a reference, therefore there's no promise it will be performed.
Tweets without a hashtag is invalid.
The same song cannot be requested twice through the same account.
If we do not know which song it is, the request will be invalid. | {
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«English writer»
(December 30, 1865 - January 18, 1936)
Joseph Rudyard Kipling was an English poet, short-story writer, and novelist chiefly remembered for his celebration of British imperialism, tales and poems of British soldiers in India, and his tales for children. Kipling received the 1907 Nobel Prize for Literature.
English writer, writer, Nobel laureate
(January 27, 1832 - January 14, 1898)
Charles Lutwidge Dodgson, better known by the pseudonym Lewis Carroll, was an English author, mathematician, logician, Anglican deacon and photographer. His most famous writings are "Alice's Adventures in Wonderland" and its sequel "Through the Looking-Glass", as well as the poems "The Hunting of the Snark" and "Jabberwocky", all examples of the genre of literary nonsense.
English writer, writer
(June 25, 1903 - January 21, 1950)
Eric Arthur Blair, better known by his pen name George Orwell, was an English author and journalist. His work is marked by keen intelligence and wit, a profound awareness of social injustice, an intense opposition to totalitarianism, a passion for clarity in language and a belief in democratic socialism.
(February 7, 1812 - June 9, 1870)
Charles John Huffam Dickens was an English novelist, generally considered the greatest of the Victorian period. Dickens enjoyed a wider popularity and fame than had any previous author during his lifetime, and he remains popular, having been responsible for some of English literature's most iconic novels and characters.
English writer, writer, novelist
(September 11, 1885 - March 2, 1930)
David Herbert Richards Lawrence was an English novelist, poet, playwright, essayist, literary critic and painter who published as D. H. Lawrence. His collected works represent an extended reflection upon the dehumanising effects of modernity and industrialisation. In them, Lawrence confronts issues relating to emotional health and vitality, spontaneity, and instinct.
Arthur Koestler
(September 5, 1905 - March 3, 1983)
Arthur Koestler was a Hungarian-British author and journalist. Koestler was born in Budapest and, apart from his early school years, was educated in Austria. In 1931 Koestler joined the Communist Party of Germany but, disillusioned by Stalinist atrocities, he resigned in 1938. In 1940 he published his novel Darkness at Noon, an anti-totalitarian work, which gained him international fame.
(October 2, 1904 - April 3, 1991)
Henry Graham Greene was an English author, playwright and literary critic. His works explore the ambivalent moral and political issues of the modern world. Greene was notable for his ability to combine serious literary acclaim with widespread popularity.
(October 28, 1903 - April 10, 1966)
Arthur Evelyn St. John Waugh, known as Evelyn Waugh, was an English writer of novels, travel books and biographies. He was also a prolific journalist and reviewer. His best-known works include his early satires Decline and Fall (1928) and A Handful of Dust (1934), his novel Brideshead Revisited (1945) and his trilogy of Second World War novels collectively known as Sword of Honour (1952–61). Waugh is widely recognised as one of the great prose stylists of the 20th century.
(April 24, 1815 - December 6, 1882)
Anthony Trollope was one of the most successful, prolific and respected English novelists of the Victorian era. Some of his best-loved works, collectively known as the Chronicles of Barsetshire, revolve around the imaginary county of Barsetshire. He also wrote perceptive novels on political, social, and gender issues, and on other topical matters.
Joseph Addison
(May 1, 1672 - June 17, 1719)
Joseph Addison was an English essayist, poet, playwright and politician. He was a man of letters, eldest son of Lancelot Addison. His name is usually remembered alongside that of his long-standing friend, Richard Steele, with whom he founded The Spectator magazine.
Jerome Klapka Jerome
Jerome Klapka Jerome was an English writer and humorist, best known for the humorous travelogue Three Men in a Boat. Jerome was born in Caldmore, Walsall, England, and was brought up in poverty in London. He attended St Marylebone Grammar School. Other works include the essay collections Idle Thoughts of an Idle Fellow and Second Thoughts of an Idle Fellow; Three Men on the Bummel, a sequel to Three Men in a Boat; and several other novels.
(July 9, 1764 - February 7, 1823)
Ann Radcliffe was an English author, and a pioneer of the Gothic novel. Her style is romantic in its vivid descriptions of landscapes, and long travel scenes, yet the Gothic element is obvious through her use of the supernatural. It was her technique of explained Gothicism, the final revelation of inexplicable phenomena, that helped the Gothic novel achieve respectability in the 1790s.
«The only history that is worth a tinker's damn is the history we make today»
«The very ink with which all history is written is merely fluid prejudice»
«Nowhere is it ordained that history moves in a straight line»
actor actress Alabama American actor American actress American Civil War American film director American inventor American musician American singer American writer Apple architect artist astronomer Austrian composer battle boxer bridge British writer Canada car chemist China comedian composer dramatist earthquake engineer English actor English musician English poet English singer English writer explorer film director fire first flight Florida France French actor French composer French mathematician French painter French poet French writer general German composer German physicist German writer guitarist historian industrialist inventor Italian composer Italian painter Italy Japan jazz journalist London magazine Mars mathematician musician Napoleonic Wars NASA naval battle New Jersey New York City Nobel laureate novelist painter patent philosopher physician physicist playwright poet politician President of the United States revolutionary Russian composer Russian painter Russian poet Russian writer scientist sculptor singer songwriter Soviet physicist space spacecraft statesman submarine UFO United States university World War I World War II writer
1521 1632 1642 1728 1732 1743 1745 1755 1759 1776 1778 1779 1781 1783 1785 1786 1788 1789 1790 1791 1792 1793 1794 1797 1798 1799 1803 1804 1805 1809 1810 1811 1812 1813 1814 1815 1816 1818 1819 1820 1821 1822 1823 1824 1826 1828 1829 1830 1831 1832 1833 1834 1835 1836 1837 1839 1841 1842 1843 1844 1846 1847 1848 1849 1850 1851 1852 1853 1854 1855 1856 1857 1858 1859 1860 1861 1862 1863 1864 1865 1866 1867 1869 1870 1871 1872 1873 1874 1875 1876 1877 1878 1879 1880 1881 1882 1883 1885 1886 1887 1888 1889 1890 1891 1892 1893 1894 1895 1896 1897 1898 1899 1900 1901 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1980 1981 1984 1985 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2003 2004 2005 2006 2007 2008 2009 2010 2011
© 2011-2019, «www.this-day-in-history.net» | {
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Let us take life easy.
Let us let go of the hurt.
Yet, let us take a deep breath.
Maybe our breath might give us Reasons to reason with life.
Though it might not be easy.
Maybe we sharing will give us more reasons to smile.
Life is shorter than it seems.
So, let us stop letting go Of our happiness.
Maybe life will give us more will to live.
Next article Every freakin' time. | {
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Homeowners invest a lot of money into their home comfort systems, so we know that no one is actively trying to break their furnace! But we often get calls for heating repairs or a furnace replacement that can be attributed to some mistakes homeowners have made in their heating system care. We've outlined three common ways homeowners can unknowingly damage their furnace – make sure you avoid them!
A furnace filter should be checked every month and replaced as needed. Over time, dust and other pollutants and particles build up on the filter, causing restricted airflow. Eventually, air is no longer able to pass through the filter and builds up in your furnace, causing your unit to overheat and shutdown. Repeatedly overheating your furnace can cause your heat exchanger, the most expensive and important part of your furnace, to crack. Once a heat exchanger cracks, it often is more economical to have a total furnace replacement than investing money into replacing the heat exchanger.
When moving into a new home or buying new furniture, most homeowners do not consider where heat registers are located. Always ensure furniture and curtains are not blocking vents and preventing air from circulating in the room. When a register is blocked, hot air is trapped in your system and can build up to the point of overheating. It can also cause plastic components and gaskets in your furnace to melt. This can eventually lead to costly heating repair bills or in the worst-case scenario – complete furnace replacement much earlier than you would have anticipated.
To ensure your furnace is running safely and at peak efficiency, a yearly inspection and tune-up by a certified professional is necessary. Certified technicians can clean heating components, make necessary adjustments to meet manufacturer specifications and diagnose any potential problems before they require costly furnace repairs later. Ignoring annual maintenance can lead to premature furnace replacement and can void manufacturer warranties on parts – leaving you on the hook for costly repair bills.
Learn more about our maintenance plans by submitting the form below. | {
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Protesters call for the arrest, the firing of Minneapolis officers
MINNEAPOLIS – Activists and relatives of a black man who was fatally shot by Minneapolis police last month said Tuesday that the officials should be fired and they continued to call for the police arrest — a day after a prosecutor announced that he was declining to file charges.
About 300 people gathered for a protest at the Hennepin County Government Center on Tuesday evening. They held signs calling for justice for Thurman Blevins, who was shot June 23 by Minneapolis officers after they chased him in an alley in north Minneapolis.
Hennepin County Attorney Mike Freeman said Monday the actions of Officers Ryan Kelly and Justin Schmidt were justified, because Blevins, 31, was armed, ignored the police commands, and turned in the direction of the police with a loaded gun.
Blevins' family members said that he's not a danger while he is absent. His sister, Darlynn Blevins, said her brother "ran for his life" because he was afraid, that the officer "emptied his clip in my brother's back."
Sydnee Brown, Blevins' cousin, said Thurman Blevins "was not a evil man on earth."
The protesters also shouted that Freeman "should go."
The officers were responding to a 911 call of a man firing a gun in the air. Body camera video released Sunday shows Schmidt and Kelly pull their cruiser and Blevins, sitting on a curb near a woman with a child in a stroller. If the officers withdraw, it is said, "He has a gun!" and they jump out of the patrol car. The officers chase Blevins and yelling at him to get his hands up or they will shoot. Blevins says, "Please don't shoot" and "Leave me alone."
An improved version of the videos is a red circle drawn around what looks like a gun in Blevins' right hand. The video shows that it will come into view as he looks over his shoulder at the officers, before he is shot.
LAPD chief: Officers to kill a hostage for the 1st time in 13 years
White Michigan officer, who said he suffered discrimination after learning he is part black and settles in the lawsuit
to connectVideoFox News Flash, important news, Jan. 20 Fox News Flash-main news, Jan. 20 to be here. Check out what to click on Foxnews.com The California Highway Patrol said Monday that the truck driver deliberately rammed his vehicle into a Toyota...
Kansas City bar shooting suspect identified
to connectVideoPolice say 2 dead, possibly 15 people injured in a Kansas City bar shooting The police in Kansas City, Missouri, say that two people are dead and at least 15 people were injured in a shooting outside a bar that they were going to keep...
Avenatti, reportedly took control of the money from the football fans
to connectVideoWhatever Happened to Michael Avenatti? The Celebrity's lawyer, Michael Avenatti was a media darling of a topic in the media and in the judicial review; Robert Gray reports. LOS ANGELES – disgraced lawyer Michael Avenatti accused...
A Dallas girl, 9, wounded by gunfire, in the movement of the car on the highway, the police said
to connectVideoFox News Flash, important news, Jan. 20 Fox News Flash-main news, Jan. 20 to be here. Check out what to click on Foxnews.com Dallas police say one man is injured and a 9-year-old girl after the recording of not less than three times...
Hawaii for a man who allegedly shot and killed, 2 officers, had a history of disputes with the law
to connectVideo2, police reportedly shot and killed in Honolulu. The suspect and a number of neighboring houses on fire, after a man allegedly opened fire on police officers responding to an assault call in the area at the foot of Diamond Head. A...
Florida man tries to hide underwater, and the police will be arrested, and, after coming up for air, police say
to connectVideoFox News Flash, important news, Jan. 20 Fox News Flash-main news, Jan. 20 to be here. Check out what to click on Foxnews.com A Florida man tried to have a "not so " great escape" last week, when he was trying to hide...
'Pillowcase Rapist" who terrorized women decades ago was arrested in Florida, police say
to connectVideoFox News Flash, important news, Jan. 20 Fox News Flash-main news, Jan. 20 to be here. Check out what to click on FoxNews.com One of the state's most hunted criminals in a notorious sex fiend, known as the "Pillowcase...
California tries to kill convicted child molester, after hitting him over the head with a stick
to connectVideoFox News Flash, important news, Jan. 20 Fox News Flash-main news, Jan. 20 to be here. Check out what to click on Foxnews.com An inmate at a central California prison and slapped with a convicted child molester over the head with a...
North Carolina, a mother, a son, was found after being kidnapped at gunpoint, search on for suspected kidnapper knew the police
to connectVideoFox News Flash, important news, Jan. 20 Fox News Flash-main news, Jan. 20 to be here. Check out what to click on Foxnews.com A North Carolina mother and her one-month-old son — who police say were kidnapped during an overnight...
Is it Time to Take Up Golf?
30,000 times per week 'no' to orgaandonorschap in registry
Consumers want insight into price differences treatments
450 Dutch women have symptoms by sterilisatiebehandeling
Ontlastingtest reduces the number of kijkonderzoeken at darmpatiënten
Patient control over electronic file
Medical research in children extended
The elderly are more likely to get Lyme disease
THAT doubles the recommended number of health visits during pregnancy
A third vijftigplussers see the internet in case of physical complaints | {
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B284DB/21CM - Unique & Co. dark brown and blue leather bracelet which is crafted with tight and strong braids of woven leather. Its stainless steel clasp is easy to use and has a strong grip. There are also two pins each end of the clasp that holds the leather securely in place. The sleek clasp is finished with a tiny detail of a gun-metal ionic plating on the pusher clip of the clasp. | {
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Page d'accueil Publications PubMed Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length.
Jun 2013 Journal of cell science
Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length.
Ghossoub R, Hu Q, Failler M, Rouyez MC, Spitzbarth B, Mostowy S, Wolfrum U, Saunier S, Cossart P, Jamesnelson W, Benmerah A
Septins are a large, evolutionarily conserved family of GTPases that form hetero-oligomers and interact with the actin-based cytoskeleton and microtubules. They are involved in scaffolding functions, and form diffusion barriers in budding yeast, the sperm flagellum and the base of primary cilia of kidney epithelial cells. We investigated the role of septins in the primary cilium of retinal pigmented epithelial (RPE) cells, and found that SEPT2 forms a 1:1:1 complex with SEPT7 and SEPT9 and that the three members of this complex colocalize along the length of the axoneme. Similar to observations in kidney epithelial cells, depletion of cilium-localized septins by siRNA-based approaches inhibited ciliogenesis. MAP4, which is a binding partner of SEPT2 and controls the accessibility of septins to microtubules, was also localized to the axoneme where it appeared to negatively regulate ciliary length. Taken together, our data provide new insights into the functions and regulation of septins and MAP4 in the organization of the primary cilium and microtubule-based activities in cells. | {
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Over the years 70 my farm has been recognized by ENCI with the name "Breeding of Nolano".
My mastiffs are known and appreciated throughout the world.
As President of the Society Amatori Neapolitan Mastiff, with my mastiffs i participated in the most important European exhibition with flattering results.
Following a careful selection Breeding of Nolano produced and reared Champions of Beauty.
E' vietata la riproduzione parziale e/o totale dei contenuti.
Sito internet realizzato da Informix sw. hw. | {
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If the person is in critical condition or hospice care, collect all required legal documents relating to suspension and confirm plans for standby and transport as soon as possible.
If the person has been legally pronounced dead and is currently a CI member, then entirely cover and cool his or her head with bags of crushed ice.
Do NOT place ice on a Member until there has been a legal pronouncement of death -- attempt to obtain a pronouncement as soon as possible.
In order to fund a suspension at the $28,000 fee, a member must sign all required CI documents themselves with their signature witnessed by a notary. The membership documents and funding must be in place for a minimum of two weeks otherwise, the suspension fee will cost $35,000 and other nonmember restrictions may apply. | {
"redpajama_set_name": "RedPajamaC4"
} |
Don't Let Coal Gerrymander Your Elections
Big Coal Money is Pouring into Whatcom County
By gerrymandering districts, coal could lock in a win for exports.
Whatcom County by George Louis used under CC BY-SA 3.0
Author: Eric de Place and Kristin Eberhard
(@Eric_deP) on October 29, 2015 at 9:46 pm
This article is part of the series Don't Let Coal Gerrymander Your Elections
Voters in Whatcom County, Washington, are about to bubble in their views on an obscure ballot measure that would tweak the structure of elections, changing from county-wide elections to district-only. It's the sort of governance minutiae that's typically overlooked by political observers and citizens alike, but in this case, the stakes are high. As we pointed out in July, Big Coal wants to lock in gerrymandering in Whatcom County.
And now we have proof. Just look at the last-minute coal money flooding in.
Original Sightline Institute graphic, available under our free use policy.
For the uninitiated, little Whatcom County in the far northwest corner of Washington has become a nationally significant battleground for climate change and the politics of dirty energy. At Cherry Point, a few minutes south of the Canadian border, coal backers have proposed to build a massive export terminal that would be the biggest in North America.
Whatcom County residents are not exactly wild about the idea of playing host to staggering quantities of the world's dirtiest fuel. So coal companies have tried to rig politics to their advantage. In 2013, we documented coal interests spending more than $170,000 to try to elect candidates who would give coal the green light. But they lost. With backing from environmental advocates, anti-coal-terminal candidates swept the election, winning all four of the Council races.
Coal interests lost that battle, so they switched tactics: gerrymandering the county elections to produce pro-coal elected officials.
All the money shown in the red segment below comes from a single source: Pacific International Terminals, the proponent of the 48-million-ton-per-year coal export terminal. (Pacific International Terminals is the project-specific subsidiary company of port industry giant SSA Marine, the real muscle behind Northwest coal exports.) In the few weeks ahead of the 2015 general election, the company has injected roughly a hundred thousand dollars into two arteries: a political action committee (PAC) called Clear Ballot Choices and the county's Republican Party.
For all intents and purposes, the PAC is nothing more than a political arm of the coal export industry. According to public campaign finance records, more than $58,000 of the PAC's funding (virtually all of it) can be traced to Pacific International Terminals.
Flush with coal export money, the PAC aims to swamp county voters with last-minute propaganda.
In addition to funding its own PAC, Pacific International Terminals also bankrolled the Whatcom County Republican Party to the tune of over $40,000, so that local GOP operatives could advance the company's pro-coal gerrymandering. It's such a huge infusion of cash that it accounts for more than a third of the entire year's funding for the county's Republican Party.
In Whatcom County, local authorities have a direct say over the land use and permitting decisions that will allow the project to go forward—or not. In other words, the composition of the Whatcom County Council matters a great deal to the future of the coal industry.
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And unfortunately, the composition of the County Council could be decided by district boundary line, not by voters. The district-only charter amendment ("Proposition No.1: Method of Electing Council Members") would eliminate the current practice of conducting primaries by district and general elections countywide and instead conduct the general election by district for six out of seven Council seats. Because the district lines are gerrymandered to slice and dice the city of Bellingham, changing the election in this way would dilute the more urban and liberal Bellingham vote and amplify the more rural and conservative vote, resulting in a disproportionately conservative Council.
No wonder Big Coal is ponying up cash for this obscure charter amendment: it could be the One Change to Rule Them All. By locking in gerrymandering for every future election, Big Coal could permanently disenfranchise anti-coal voters, making it easier for pro-coal candidates to win in every future Whatcom County election until the coal export terminal gets built.
UPDATE 11/1/115: Bellingham resident Alex Ramel has filed a complaint with the Washington Public Disclosure Commission, alleging that Pacific International Terminals has committed three "serious" violations of state election law in the timing and reporting of its last-minute contributions.
Notes: Our tally of contributions to the Whatcom County Republican Party includes both exempt and non-exempt pools of money. If we counted only exempt money (the category that the coal industry claims to be contributing to), then the industry would account for more than 75 percent of the total.
Eric de Place, Senior Fellow and former director of the Thin Green Line program, spearheaded Sightline's work on energy policy for two decades. Known as a leading expert on coal, oil, and gas export plans in the Pacific Northwest, he is considered an authority on a range of issues connected to fossil fuel transport, including carbon emissions, local pollution, transportation system impacts, rail policy, and economics. Find his research here.
Kristin Eberhard
Kristin Eberhard, Director, Climate and Democracy, is a researcher, writer, speaker, lawyer and policy analyst who spearheads Sightline Institute's work on democracy reform and on climate action. She is the author of the book, Becoming a Democracy: How We Can Fix the Electoral College, Gerrymandering, and Our Elections. She is known as a leading expert on electoral reform in the Pacific Northwest, and is considered an authority on proportional representation as well as carbon pricing. Read her full bio here, and email her at kristin [at] sightline [dot] org.
New WA Bill Would Hold Big Oil Accountable for Oil Spills
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King County Sets the Standard for Clean Energy Financing
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Tagged in: Coal, Elections, Money in Politics, SSA Marine, Voting Rights, Whatcom County
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The continued enthusiasm by the GPT consortium for constructing a coal export terminal is perplexing, at least when considered in economic terms. Supposedly, China's constricting economy and the increasing public health problems associated with coal-fueled power plants have dimmed enthusiasm there for imports. Cloud Peak (at least according to Sightline) is paying penalties, rather than exporting coal at a loss. So, evidently, there is little if any money in this commodity for the near-term future and the distant economic horizon is too speculative to appeal to most investors. That's why Gildman Sachs cut this project loose.
Another issue is the gerrymandered districting. Presumably, the resolute opposition of the Lummi Natuon and the decision of the Army Corps of Engineers have some bearing on the outcome: it's not simply up to the Council members, as implied in the article. Even if the gerrymandered Council can't succeed with GPT, they can always allow "big box" stores on rural agricultural land, so all is not lost for "development".
Hopefully, the inherent contradictions of the coal terminal will eventually become obvious to the "pragmatists" running the consortium because, if Sightline reports are accurate, shareholders will be taking the "deciders" over the coals (pun intended) when their investments evaporate.
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Water can be solid, a liquid, or a gas. Solid, liquid, and gas are all states, or phases, of water.
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Videos and Print Materials are available through a Creative Commons 4.0 Attribution Non-Commercial ShareAlike International License. | {
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Welcome our new Dealer in the Vendor's Tents - Ben Stoeger's Pro Shop - Announcements - Brian Enos's Forums... Maku mozo!
Please visit and welcome our new Dealer in the Vendor Tents - Ben Stoeger Pro Shop.
Look forward to shopping with you, soon. | {
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Blue State Group Show. Night Gallery. Los Angeles. Photos
"Night Gallery is pleased to announce Blue State, a group exhibition featuring the work of Cameron Crone, Cynthia Daignault, Paul Kremer, Divya Mehra, Monique Mouton, Elizabeth Marcus-Sonenberg, and Elise Rasmussen. Blue State explores the invention of "blueness" through various historical narratives, examining the role of the color blue as a catalyst for geographic and technological discovery. The starting point for this exhibition was Elise Rasmussen's study of the cyanometer, a device created by 18th-century Swiss scientist and alpine enthusiast Horace-Bénédict de Saussure to measure the blueness of the sky. Saussure's apparatus would prompt the first expedition to the summit of Mont Blanc, the highest mountain in the Alps. Once the essence that inspired scientific pilgrimage, blueness is now itself a geographic measuring instrument, serving as a shorthand to map political constituencies across the American landscape. District by district, blueness blankets a matrix of values under a single shade of establishment liberalism. A desire for exactness, for natural blueness rich in detail and meaning, has given way to its opposite: blueness as projection, a tool of blurring and false ascription. Blue acts as not as an organizing principle but as an organizing force, one that points us at once to the paradoxes of discovery and repression, of global apocrypha and intimate secrets, of the joy of nature and its dissolution into the ether." | {
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Zambon S.p.A., an international pharmaceutical company strongly committed to the central nervous system (CNS) therapeutic area, and its partner Newron Pharmaceuticals S.p.A. ("Newron") (SIX: NWRN), a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central nervous system (CNS) and pain, today announced the availability of Xadago® (safinamide) in the United Kingdom.
Andrew Lees, MD FRCP, FMedSci, Professor of Neurology, (The National Hospital for Neurology and Neurosurgery, Queen Square and Emeritus Director, Reta Lila, Weston Institute of Neurological Studies, University College London, Institute of Neurology) said: "After 10 years with no new drugs for Parkinson's disease I welcome the addition of another effective treatment option for patients".
Maurizio Castorina, CEO of Zambon S.p.A. said: "We are committed to developing innovative therapies for patients suffering from PD and other central nervous system diseases. Xadago®offers PD patients a novel therapeutic option in the treatment of this progressive disease".
The U.K is the latest country launching Xadago®, which is also available in seven other countries: Germany, Switzerland, Spain, Italy, Belgium, Denmark, and Sweden.
Safinamide is a new chemical entity with a unique mode of action including selective and reversible MAO-B-inhibition and blocking of voltage dependent sodium channels which leads to modulation of abnormal glutamate release. Clinical trials have established its efficacy in controlling motor symptoms and motor complications in the short term, with data supporting this effect over 2 years. Results from 6 month double-blind controlled studies suggest that safinamide shows statistically significant effects on motor fluctuations (ON/OFF time) without increasing the risk of developing troublesome dyskinesia. Safinamide is a once-daily dose and has no diet restrictions. Zambon has the rights to develop and commercialize Xadago® globally, excluding Japan and other key territories where Meiji Seika has the rights to develop and commercialize the compound. The rights to develop and commercialize Xadago® in the USA have been granted to US WorldMeds, by Zambon.
Newron (SIX: NWRN) is a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central nervous system (CNS) and pain. The Company is headquartered in Bresso near Milan, Italy. In addition to Xadago® for Parkinson's disease, Newron has a strong pipeline of promising treatments for rare disease patients at various stages of clinical development. | {
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Special Olympics - World Games - Los Angeles 2015
Special Olympics World Games
Athletes warm up before competing in the rhythmic gymnastics of the Special Olympics at UCLA on Monday.
Puerto Rico gymnasts, from left, Eugenia Farinacci, Nioshka Rodas and Valeria Vasquez pray before competing in the rhythmic gymnastics of the Special Olympics at UCLA.
Puerto Rico gymnast Eugenia Farinacci prepares for competition in the rhythmic gymnastics of the Special Olympics at UCLA.
Mexico's Asherat Ceja gets a hug from coaches after competing in the rhythmic gymnastics of the Special Olympics at UCLA.
Fans watch the rhythmic gymnastics competition in the Special Olympics at UCLA.
Special Olympics triathlon
Spectators cheer as the winner of the women's division, Florencia Barranque, from Uruguay, runs next to teamate Damian Barrera as they cross the finish line in the triathlon during the Special Olympics in Long Beach on Sunday.
Women's division winner Florencia Barranque, from Uruguay, gets a hug from her team after the triathlon during the Special Olympics in Long Beach on Sunday.
Athletes from the men's division of the triathlon jump into the water for the first leg of the race during the Special Olympics in Long Beach on Sunday.
Spectators cheer on athletes from the men's division of the triathlon during the Special Olympics in Long Beach on Sunday.
Athletes from the women's division of the triathlon jump into the water for the first leg of the race during the Special Olympics in Long Beach on Sunday.
Costa Rica's Bryan Alvarado crosses the finish line of the triathlon during the Special Olympics in Long Beach on Sunday.
Medals at the finish line for the triathlon before they are passed out during the Special Olympics in Long Beach on Sunday.
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I'm Jonathan, and this is my little house on the Internet. Come on in and make yourself comfortable.
First blog posts are a sort of genre of their own — a dreadfully dull genre, I'm afraid — wherein I introduce myself and state all of my plans and goals for the blog, before I (a) utterly neglect the blog, or (b) take it in a completely different direction.
If you're reading this, I assume you probably already know me in real life; I'm not sure why else you would be here. But in case you don't, here's what you'll need to know to make sense of this: I'm a Christian (Presbyterian, to be specific, and PC(USA) to be even more specific), and I'm gay. | {
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After 7 years of hard work by the Friends of Atherton Tablelands Rail Trail and the Tableland Regional Council, work will begin on removal of the rails and sleepers shortly and be completed by December 2013.
It is hoped that the Mareeba Shire Council will continue this Trail at a later date.
Construction on the first stage of this Rail Trail will start in early 2014 and be complete by mid 2014. | {
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He was gifted from a young age, taking inspiration from his surroundings, growing up in a musical family of diverse origins. Mr Zincke then chose to leave the UK and join his cousins who were exiled on the French Riviera, and there he discovered the live music scene he'd always dreamed of. He played every night around the cafes and bars of Nice, which became his adopted home. | {
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With its cool, maritime climate, Casablanca Valley has the perfect conditions for this racy, minerally, dry Riesling. Bright straw in colour with delicate aromas of lemon peel, apricot and a touch of quince jelly, the lush palate is ripe and juicy with crisp balancing acidity and a long, minerally finish.
Enjoy this lovely Riesling on its own or along side your favourite cheese and cured meats.
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Uncomplicated, zesty, hugely-enjoyable Sauvignon from the well-respected Quarisa family. | {
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Now that the vaping culture is seen as more than just a fad or a trend and is actually a lifestyle choice, we're also seeing some vaping stereotypes rise above the ashes of smoking.
The guest post below, submitted on behalf of Vaping360, talks about some of the more common stereotypes that can be seen in today's vaping culture.
5 Vaping Culture Stereotypes: Which One Are You?
The thing about vaping that's got us so hooked is that our bodies just genuinely enjoy it. You never get that needy craving that cigarettes give, making the whole of your body beg to take a smoke break.
Most of us vape because it is fun, but not necessarily because we are addicted. But, do you know the type of vaper you are?
Here are 5 common stereotypes; maybe one will sound familiar to you.
This is a vaper who's always wearing 'hipster' clothing. For them, vaping is all about a real fix of nicotine and some great flavor.
High watt mods and low resistance coils are their preferred choice as their aim is to blow out a whole lot of vapor clouds, without caring about those around them.
You are likely to spot the cloud is the limit type of vaper in a vape shop surrounded by other vapers as they compete to blow out the most impressive cloud.
These vapers may also be more inclined to use a portable vaporizer for dry herb as opposed to a standard vape pen.
This is the vaper most of us probably aspire to be. They're constantly learning new vape tricks with their vaping device and will keep a group of people constantly entertained.
This is the vaper that probably spends more of their time talking about vaping than actually vaping. They're constantly campaigning for it and will come down on anyone who tries to call it a health risk.
Whenever a non-vaper tries to tell them how bad it is, they'll already have a pre-prepared speech to shut them down. Some may go as far as taking part in movements, whilst others may simply stick to verbal tactics.
This category in the vaping culture is your typical attendants at the vape shop. They have a great love for vaping and more often than not can't be bothered with the clients.
While there are a good number of friendly attendants in vape shops, this particular one would be happier if all the clients would just disappear and let them enjoy some uninterrupted vaping.
They become extremely irritated when asked rookie questions. Perhaps the best time of day for this attendant is closing up shop at the end of the night, sitting in the backroom and vaping away before heading home.
This is the most excited vaper you are ever going to meet, and they also love getting free vaping stuff. Know of a person who is always asking for a free sample? They go from one vaping shop to another looking for a free goodie.
They'll probably be looking to purchase a vape starter kit as their knowledge on what to buy may be limited. Needless to say, that this is the biggest enemy of the brooding vape attendant.
The favorite pastime of a vaping clown is relaxing with the freebies they managed to score for the day. Eventually, their knowledge will expand and they'll constantly be bombarding you with everything they think they know.
Do you fit into any of these vaping culture categories or do you know of anyone who does? Or maybe you know of another stereotypical vaper we've missed? Let us know in the comments! | {
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PARIS, Feb 6 (Reuters) - The French Senate on Wednesday voted in favour of allowing the state to lower its minority stake in gas and power group Engie, despite rejecting a proposal to privatise airport operator ADP earlier in the week.
The French state owns 23.64 percent of Engie's capital and 34 percent of the shares' voting rights, and is required by law to keep at least 33 percent of the voting rights.
Finance Minister Bruno Le Maire told the Senate that if Engie wanted to issue new capital to finance its expansion, the state would have no choice but to subscribe to respect the law.
"That is why we ask for the possibility to lower the state's stake in Engie below the legal limit," Le Maire told senators.
The government has given no indication of how much of its shares it may want to sell.
The Senate, controlled by the conservative opposition, voted 250 against 92 in favour of the government proposal.
A no-vote could only have delayed the operation, rather than definitively block it, since the Assemblee Nationale lower house of parliament - where President Emmanuel Macron's centrist LREM party has a comfortable majority - has the final vote.
"The logic is the same for all government asset sales, we want to give (these companies) the chance to grow and develop," Le Maire said, adding that Engie would boost its investment in renewable energy, notably biogas and offshore wind power. | {
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Research ArticleCELL BIOLOGY AND SIGNAL TRANSDUCTION
Interaction of Calmodulin, a Sorting Nexin and Kinase-Associated Protein Phosphatase with the Brassica oleracea S Locus Receptor Kinase
Vincent Vanoosthuyse, Gabrielle Tichtinsky, Christian Dumas, Thierry Gaude, J. Mark Cock
Vincent Vanoosthuyse
Gabrielle Tichtinsky
Christian Dumas
Thierry Gaude
J. Mark Cock
Published October 2003. DOI: https://doi.org/10.1104/pp.103.023846
Recognition of self-pollen during the self-incompatibility response in Brassica oleracea is mediated by the binding of a secreted peptide (the S locus cysteine-rich protein) to the S locus receptor kinase (SRK), a member of the plant receptor kinase (PRK) superfamily. Here, we describe the characterization of three proteins that interact with the cytosolic kinase domain of SRK. A B. oleracea homolog of Arabidopsis kinase-associated protein phosphatase was shown to interact with and dephosphorylate SRK and was itself phosphorylated by SRK. Yeast (Saccharomyces cerevisiae) two-hybrid screens identified two additional interactors, calmodulin and a sorting nexin, both of which have been implicated in receptor kinase down-regulation in animals. A calmodulin-binding site was identified in sub-domain VIa of the SRK kinase domain. The binding site is conserved and functional in several other members of the PRK family. The sorting nexin also interacted with diverse members of the PRK family, suggesting that all three of the interacting proteins described here may play a general role in signal transduction by this family of proteins.
Plant genomes encode large numbers of receptors with Ser/Thr protein kinase activity. These plant receptor kinases (PRKs) are related to, but phylogenetically distinct from, the receptor Tyr kinase (RTK) and receptor Ser/Thr kinase (RSK) families in animals, suggesting that the three families have evolved independently from a common ancestor (Shiu and Bleecker, 2001). The independent evolution of these gene families is reflected in the fact that, to date, none of the proteins that have been shown to interact with PRKs are closely homologous to RTK- and RSK-interacting proteins. However, despite the many differences between plant and animal receptor kinase systems, there are indications that they function in a similar manner with, for example, unrelated interacting proteins carrying out analogous roles in the two kingdoms (Cock et al., 2002).
One of the best characterized PRKs is the S locus receptor kinase (SRK). SRK is located in the plasma membrane of the stigmatic papillar cells and is the female component of the self-incompatibility (SI) response in Brassica spp. (Stein et al., 1991; Delorme et al., 1995; Takasaki et al., 2000). The SI response allows the recognition and rejection of self-pollen grains on the stigma surface and, hence, promotes outcrossing (Cock, 2000). There is now strong evidence that SRK mediates self-pollen recognition by binding to a small, secreted peptide, S locus Cys rich (SCR), located in the pollen coat (Schopfer et al., 1999; Takayama et al., 2000, 2001; Shiba et al., 2001; Kachroo et al., 2001).
SRK is phosphorylated after an incompatible pollination (Cabrillac et al., 2001), and in vitro experiments indicate that activation of SRK may involve autophosphorylation between SRK molecules associated in the membrane (Giranton et al., 2000). This suggests that SRK is activated by a mechanism similar to that described for animal receptor kinases (Heldin, 1995).
The signal transduction pathway downstream of SRK has been partially characterized. ARC1 (arm repeat containing 1; a complex protein with multiple domains including a Leu zipper, a U box, and a C-terminal Arm repeat domain; accession no. AJ427335) interacts with the SRK kinase domain and is required for efficient rejection of self-pollen (Gu et al., 1998; Stone et al., 1999). ARC1, which has E3 ubiquitin ligase activity, is thought to mediate pollen rejection by promoting the ubiquitination of compatibility factors in the pistil (Stone et al., 2003).
There are also indications that negative control of SRK signaling may play a role in SI signaling, both in the basal state, before pollination, and after SRK activation. SRK interacts with two thioredoxin h-like proteins (THL1 and THL2; Bower et al., 1996). THL1 inhibits constitutive autophosphorylation of SRK in the absence of ligand (Cabrillac et al., 2001), and its interaction with SRK requires the presence of a conserved Cys residue on the cytoplasmic side of the SRK transmembrane domain (Mazzurco et al., 2001). Therefore, THL1 appears to act as a basal state inhibitor, in a manner analogous to FKBP12, which binds to and prevents activation of transforming growth factor β receptor II (Wang et al., 1996).
SRK also interacts, in vitro, with Arabidopsis kinase-associated protein phosphatase (KAPP; accession no. AJ427336; Braun et al., 1997). KAPP interacts with many other PRKs (Braun et al., 1997; Williams et al., 1997; Stone et al., 1998; van der Knaap et al., 1999; Gomez-Gomez et al., 2001); for example, KAPP is phosphorylated by CLV1 (CLAVATA1) and dephosphorylates the kinase domain of this receptor in vitro (Williams et al., 1997; Stone et al., 1998). Experiments in which KAPP expression has been manipulated in transgenic plants indicate that KAPP is a negative regulator of both CLV1 and FLS2, and it has been proposed that KAPP has a general role in the down-regulation of a large spectrum of PRKs (Williams et al., 1997; Stone et al., 1998; Gomez-Gomez et al., 2001). Endocytosis is known to occur in plants (Emans et al., 2002), and KAPP may also have an important role in regulating PRK internalization. When the PRK AtSERK1 was transiently co-expressed with KAPP, the former was sequestered in intracellular vesicles (Shah et al., 2002).
Down-regulation and internalization by endocytosis are essential for correct regulation of receptor kinases in animals, and a wide range of mechanisms have been described, including inhibitors acting on receptors in their basal state; regulation by dephosphorylation, by phosphorylation, or by calmodulin binding; Cbl-mediated receptor ubiquitylation; and sorting nexin-mediated targeting to endosomes (San José et al., 1992; Kurten et al., 1996; Wang et al., 1996; Martín-Nieto and Villalobo, 1998; Feinmesser et al., 1999; Carraway III and Sweeney, 2001; Östman and Böhmer, 2001). Moreover, individual receptors may be regulated by several of these processes.
We show here that SRK interacts with and is dephosphorylated by the Brassica homolog of KAPP, indicating that this protein plays a role in SRK down-regulation. SRK was also shown to interact with calmodulin and a sorting nexin, both of which are proteins that have been implicated in receptor kinase down-regulation in animals. KAPP, calmodulin, and the sorting nexin also interact with additional, diverse PRKs. The possible roles of these three proteins in PRK down-regulation and endocytosis are discussed.
SRK Interacts with a Brassica oleracea Homolog of KAPP
The demonstration that the Arabidopsis KAPP protein interacts with SRK in vitro (Braun et al., 1997) suggested that a similar interaction may occur in stigmas between SRK and a Brassica homolog of KAPP. A B. oleracea KAPP homolog was isolated from a stigma cDNA library and shown to share 80.1% similarity overall with Arabidopsis KAPP at the amino acid level. Interaction between Arabidopsis KAPP and PRKs is mediated by a forkhead-associated (FHA) domain (Li et al., 1999). The Brassica KAPP FHA domain is highly similar to that of Arabidopsis KAPP, including the presence of four highly conserved residues that are required for binding to phosphoproteins (Fig. 1A).
Interaction of the Brassica KAPP and SRK proteins. A, Alignment of the FHA domains from the Brassica (Bo KAPP) and Arabidopsis (At KAPP) KAPP proteins and yeast (Saccharomyces cerevisiae) RAD53 (Sc RAD53). Arrowheads indicate residues required for binding of Arabidopsis KAPP to PRKs (Li et al., 1999). B, Kinase interaction (KI) domain of Brassica KAPP and the C-terminal end of ARC1 (containing the Arm repeats) interact with the wild type but not with a kinase-inactive form of the SRK29 kinase domain in the yeast two-hybrid assay. Different numbers of yeast strain PJ69-4A cells expressing the prey and bait indicated above and below the panel, respectively, were inoculated by spotting onto selective medium lacking His and adenine and grown at 30°C for 5 d. C, Phosphorylation of Brassica KAPP by SRK. Glutathione S-transferase (GST) fusion proteins with Brassica KAPP or with either wild-type or mutant forms of the SRK29 kinase domain were mixed in phosphorylation reactions as indicated. The KAPP and SRK fusion proteins are indicated by arrowheads. Proteins were detected by autoradiography (top) or by immunoblotting with an anti-GST antibody (bottom). Note that the active form of the SRK29 kinase domain was detected as a diffuse band (indicated by a bar). Phosphatase treatment showed that this was due to the presence of differentially phosphorylated isoforms (data not shown). D, Dephosphorylation of SRK by KAPP. Radiolabeled, phosphorylated GST::SRK29kin was incubated in the presence or absence of GST::KAPP, and the proteins were separated on an SDS-PAGE gel. Radiolabeled GST::SRK29kin was detected by autoradiography (top) and total GST::SRK29kin protein was detected with an anti-GST antibody (bottom).
We used the yeast two-hybrid system to test whether Brassica KAPP interacts with the kinase domain of SRK. The KI domain of Brassica KAPP was expressed as a fusion protein with the activation domain of Gal4 (Gal4AD::KI) in yeast cells that also expressed the kinase domain of SRK29 fused to the DNA-binding domain of Gal4 (Gal4DB::SRK29kin). As a positive control for this experiment, we tested whether the kinase domain of SRK interacted with ARC1 in this system. For this, we cloned the Arm-repeat region of a B. oleracea homolog of ARC1 (residues 362–661) and expressed it as a fusion protein with Gal4 (Gal4AD::ARC) in the same kinase domain-expressing yeast strain. ARC1 has been shown to interact with SRK in closely related B. napus (Gu et al., 1998). Both combinations of interactors were able to induce all three reporter genes in the PJ69-4A strain (James et al., 1996), leading to His and adenine prototrophy (Fig. 1B) and production of α-galactosidase enzyme activity (data not shown). In contrast, neither the KAPP nor the ARC1 fusion proteins interacted with an enzymatically inactive, mutant form of the SRK29 kinase domain (Gal4DB::SRK29kinK561R; Fig. 1B). These observations corroborate previous studies that have shown that ARC1 and Arabidopsis KAPP interact only with the phosphorylated form of the SRK kinase domain (Braun et al., 1997; Gu et al., 1998).
To test whether KAPP could be phosphorylated by SRK, a fusion protein consisting of GST fused to Brassica KAPP lacking its predicted N-terminal signal anchor (residues 1–47) was expressed in Escherichia coli, and the purified protein (GST::KAPP) was added to a phosphorylation reaction in the presence of either the wild type or a mutant form of the SRK29 kinase domain that had also been expressed in E. coli as protein fusions with GST (GST::SRK29kin and GST::SRK29kinK561R). KAPP was phosphorylated by the wild-type SRK29 kinase but not by the kinase-negative mutant form (Fig. 1C). A phosphorylation assay confirmed that the wild-type kinase domain construct, GST::SRK29kin, was capable of autophosphorylation in vitro, whereas the mutant form, GST::SRK29kinK561R, was enzymatically inactive (data not shown).
Furthermore, Figure 1D shows that when GST::KAPP was added to radiolabeled, phosphorylated GST::SRK29kin in vitro, the latter was dephosphorylated, indicating that SRK is a substrate for the phosphatase activity of KAPP.
Identification of Novel SRK-Interacting Proteins Using the Yeast Two-Hybrid System
The above experiments showed that the kinase domain of SRK29 was able to interact specifically with KAPP and ARC1 in the two-hybrid assay. Based on this result, we initiated a screen to identify novel interacting partners using the two-hybrid system. Several two-hybrid screens were performed, using both wild-type (Gal4DB::SRK29kin) and mutant (Gal4DB::SRK29kinK561R) forms of the SRK kinase domain and the kinase domain of SFR1 (Gal4DB::SFR1kin), a receptor closely related to SRK that is also expressed in stigmas (Pastuglia et al., 2002). After each screen, potential interactors were co-expressed with a fusion between murine p53 (residues 72–390) and the Gal4 DNA-binding domain (Gal4DB::p53) to eliminate nonspecific interactions. Four novel interactors were identified in these screens, the most interesting being calmodulin and a Brassica SNX1 (sorting nexin 1; accession no. AJ441072) homolog (Table I). Calmodulin cDNAs were recovered in screens with all three bait proteins, and the interaction was confirmed in a second yeast strain, Y190, using both wild-type and mutant SRK kinase domain constructs (data not shown).
Table I.
Interaction of ARC1, KAPP, and calmodulin with the kinase domains of SRK and SFR1 in the yeast two-hybrid system
The calmodulin cDNAs identified in the three screens corresponded to two different genes (designated Calmodulin 1, accession no. AJ427337; and Calmodulin 2, accession no. AJ427338) that differed significantly in their 3′ non-translated regions. However, the coding regions of these two calmodulin genes are 93.2% identical, and they encode identical proteins. The deduced amino acid sequence of the Brassica calmodulins is 98.0% identical to that of a previously described B. napus calmodulin (accession no. AF150059).
SRK Interacts with Calmodulin in Vitro
Calmodulin-Sepharose affinity binding was carried out to confirm the interaction between calmodulin and the kinase domain of SRK. Figure 2A shows that fusion proteins consisting of GST plus either the wild type or a mutant form of the SRK29 kinase domain bound to calmodulin-Sepharose beads in the presence of 5 mm CaCl2 and were eluted from the beads when the 5 mm CaCl2 was replaced by 5 mm EGTA. When GST alone was loaded on the column, some protein bound to the beads, but this was removed by washing with 5 mm CaCl2 and was not specifically eluted by 5 mm EGTA.
Calmodulin binds to the kinase domain of SRK in vitro. A, Binding of GST or the GST protein fused with either wild-type or mutant forms of the SRK29 kinase domain to calmodulin-Sepharose beads. GST-containing proteins were detected with an anti-GST antibody. B, Binding of the integral SRK protein to calmodulin-Sepharose beads. A recombinant hexa-His epitope-tagged, kinase-inactive form of SRK (mSRK3His; Giranton et al., 2000) was used for this experiment. SRK protein was detected with the monoclonal antibody MAb85-36-71 (Giranton et al., 2000). C, Binding of Brassica calmodulin to glutathione-Sepharose beads carrying either GST or GST protein fused to either wild-type or mutant forms of the SRK29 kinase domain. Eluted proteins were detected by silver staining. Note that calmodulin alters its conformation in the presence of calcium resulting in a change in mobility. CAM, Calmodulin with no bound Ca2+; CAM/Ca, calmodulin with bound Ca2+; C, purified fusion protein; UB, unbound fraction; W1 and W40, washes; E1 to E4, eluted fractions. C and UB, One-quarter of the amount of protein loaded on and unbound to the column, respectively.
Similarly, when a kinase-negative, hexa-His epitope-tagged form of the integral SRK3 protein (mSRK3His) expressed in insect cells was subjected to calmodulin-Sepharose affinity binding, the recombinant protein bound to the calmodulin-Sepharose beads and was eluted in the presence of 5 mm EGTA (Fig. 2B).
The interaction between the kinase domain of SRK and calmodulin was also confirmed using an alternative affinity-binding approach. GST alone or fused to either the wild type or the mutant form of the SRK29 kinase domain was bound to glutathione-Sepharose beads. Brassica calmodulin 2 tagged with a hexa-His epitope was then expressed in insect cells, affinity purified on nickel-nitrilotriacetic acid agarose beads, and applied to beads carrying the SRK fusion proteins in the presence of calcium. After washing, calmodulin was specifically eluted from the beads in the presence of 5 mm EGTA. Figure 2C shows that calmodulin bound to beads carrying both wild-type and mutant kinase domain protein fusions but not to beads carrying GST alone.
Calmodulin Interacts with an Amphiphilic Helix in Sub-Domain VIa of the SRK Kinase Domain
Calmodulin has been shown to interact with its target proteins by binding to small amphiphilic α-helices (Erickson-Viitanen and DeGrado, 1987). To identify the region of SRK responsible for the interaction with calmodulin, we searched for small amphiphilic α-helices in the SRK kinase domain using multiple secondary structure prediction programs. Two small potential helices were found in subdomains VIa and VII (for a definition of the kinase sub-domains, see Hanks et al., 1988). Comparison of all the SRK alleles available in the databases showed that all of the deduced proteins were predicted to possess an amphiphilic helix at the same position in sub-domain VIa. Therefore, this region, designated HEL1, was selected for further study. The HEL1 region of the SRK3 protein (amino acids 617–643 of SRK3) is shown in Figure 3A as a helical projection. The amphiphilic nature of this region is indicated by the black bar.
Calmodulin binds to sub-domain VIa of the kinase domain of SRK in vitro. A, Amino acid sequence of the HEL1 region of sub-domain VIa of SRK3. The wheel projection shows the amphiphilic nature of HEL1. The sequence of the control peptide PEP1 is also shown. B, Binding of GST::HEL1 and GST::PEP1 fusion proteins to calmodulin-Sepharose beads. GST-containing proteins were detected with an anti-GST antibody. C, purified GST fusion protein; UB, unbound fraction; W1 and W40, first and last washes; E1 to E4, eluted fractions.
Figure 3B shows that, when the HEL1 peptide was fused to GST (GST::HEL1), the fusion protein bound to calmodulin-Sepharose beads and was eluted in the presence of 5 mm EGTA, indicating that HEL1 interacts specifically with calmodulin. GST fused to a non-helical, nonamphiphilic peptide of the same size as, and of similar hydrophilicity to, HEL1 (PEP1 in Fig. 3A) did not bind to calmodulin-Sepharose beads (Fig. 3B).
Calmodulin Interacts with the Kinase Domains of a Wide Range of PRKs
The fact that calmodulin interacted with the kinase domains of both SRK and SFR1 in the yeast two-hybrid assay (Table I) indicated that this interaction was not specific to SRK and suggested that calmodulin may interact with other receptor kinases. To test this, we expressed both wild-type and mutant forms of the SFR1 kinase domain and wild-type kinase domains of three additional members of the PRK superfamily, RLK4 (receptor-like kinase 4), CLV1, and BRI1 (brassinosteroid insensitive 1) as fusion proteins with either GST or the maltose-binding protein (MBP). RLK4 is a member of the S gene family of receptor kinases but is distantly related to SRK (approximately 25% amino acid identity depending on the allele of SRK); CLV1 and BRI1 are members of the family of PRKs that contain Leu-rich repeats in their extracellular domains. All five of the recombinant proteins were then purified and subjected to a calmodulin affinity-binding assay. Figure 4A shows that all the proteins tested, apart from GST::BRI1kin, bound to the calmodulin-Sepharose beads in the presence of 5 mm CaCl2 and were eluted after addition of 5 mm EGTA. Analysis of the sub-domain VIa regions of these proteins showed that all except BRI1 were predicted to include amphiphilic helices. Therefore, the presence of a predicted amphiphilic helix in kinase sub-domain VIa was correlated with the ability to bind calmodulin.
Calmodulin binds to the kinase domains of SFR1, RLK4, and CLV1, but not BRI1, in vitro. A, Analysis of the binding of the kinase domains of SFR1, RLK4, CLV1, and BRI1 to calmodulin-Sepharose. The kinase domains were expressed as fusion proteins with either GST or MBP. Both a wild-type (GST::SFR1kin) and a kinase-inactive mutant form (GST::SFR1kinK555R) of the SFR1 kinase domain were tested. GST- and MBP-containing proteins were detected with anti-GST and anti-MBP antibodies, respectively. B, Abundance of calmodulin transcripts in different Brassica organs. Calmodulin transcripts were detected with a probe corresponding to the entire coding sequence. Lower, Ethidium bromide-stained rRNA. The positions of RNA size markers are shown at right in kilobase pairs. R, Root; C, cotyledon; L, leaf; Se, sepal; P, petal; A, anther; O, ovary; St, stigma.
Interestingly, we consistently observed that MBP::RLK4kin was eluted from the calmodulin-Sepharose beads in two peaks, indicating the presence of more than one calmodulin-binding site in the RLK4 kinase domain, the sites having different binding affinities.
The expression pattern of calmodulin was consistent with it interacting with multiple PRKs expressed in different parts of the plant because transcripts were detected in a wide range of organs (Fig. 4B).
Calmodulin and SRK Autophosphorylation
We were interested in determining whether calmodulin binding modified SRK autophosphorylation because HEL1 is located close to the activation loop in the kinase domain of SRK. In a kinase assay carried out in vitro, addition of calmodulin in the presence of 5 mm CaCl2 did not prevent autophosphorylation of GST::SRK29kin, and calmodulin was not phosphorylated by the kinase domain fusion protein (data not shown). The same result was obtained when the experiment was repeated with full-length SRK protein that had been expressed in insect cells (data not shown). This result suggests that calmodulin binding has no direct effect on SRK kinase activity. Again, calmodulin was not phosphorylated in these reactions, indicating that it is not a substrate of SRK kinase activity.
Interaction of SRK with a Sorting Nexin
Sorting nexins have been implicated in cargo trafficking through the endosomal system in mammals and yeast, and several members of this family interact with animal receptor kinases (Kurten et al., 1996; Haft et al., 1998; Parks et al., 2001; Teasdale et al., 2001). Therefore, we were particularly interested when a Brassica sorting nexin homolog (Brassica SNX1) was isolated as an interactor with the mutant form of the SRK29 kinase domain in the yeast two-hybrid screen (Table I).
Sequence analysis showed that Brassica SNX1 was most similar to an SNX1 homolog from Arabidopsis but also shared extensive similarity with human (Homo sapiens) SNX1 (Fig. 5A). Human SNX1 contains a PX domain plus three predicted coiled-coil domains in the C-terminal part of the protein. Comparison of the PX domains of sorting nexins has allowed the identification of three highly conserved motifs, two of which (RRY/FSD/EFxxLxxxL and RR/KxxLxxY/F where x is any amino acid) are predicted to form a basic pocket involved in phosphoinositol binding and a third, Pro-rich motif (PPxPxK), which may be involved in protein-protein interactions (Sato et al., 2001; Xu et al., 2001). All three of these motifs are present in Brassica SNX1. Moreover, the COILS algorithm (Lupas, 1996) predicts a coiled-coil domain between residues 320 and 370 of Brassica SNX1, and the BLAST algorithm (Altschul et al., 1990) is able to match this region to human SNX1 in database searches (Fig. 5A). Hence, there are extensive similarities between human SNX1 and Brassica SNX1, suggesting that these two proteins carry out similar functions.
Sequence analysis of Brassica SNX1 and the sorting nexin family in Arabidopsis. A, Alignment of Brassica SNX1 (Bo SNX1) with Arabidopsis (At SNX1) and human (Hs SNX1) SNX1. Residues conserved in at least two proteins are shaded. The phox homology (PX) and coiled-coil domains of Brassica SNX1 are overlined with a continuous and a dotted line, respectively. B, Neighbor-joining tree based on an alignment of the PX domains of Brassica SNX1 and of the Arabidopsis, human, and yeast sorting nexin families. The tree was constructed using the PAM250 amino acid substitution matrix. Numbers next to the branches are bootstrap values expressed as percentage confidence level and based on 1,000 repeats. The PX domain of human PI-3 kinase was used to root the tree. The PX domain polypeptide sequences compared were Brassica SNX1, Arabidopsis SNX1 (At SNX1; accession no. At5g06140), SNX2a (At SNX2a; At5g58440), and SNX2b (At SNX2b; At5g07120), several human (Hs SNX1, Q13596; Hs SNX2, O60749; Hs SNX3, O60493; Hs SNX4, O95219; Hs SNX5, Q9Y5X3; Hs SNX6, Q9UNH7; Hs SNX7, Q9UNH6; Hs SNX8, Q9Y5X2; Hs SNX9, Q9Y5X1; Hs SNX10, Q9Y5X0; Hs SNX11, Q9Y5W9; Hs SNX12, Q9UMY4; Hs SNX15, Q9NRS6), and yeast (Sc YJL036W, S56808; Sc Vps17p, NP_014775; Sc Mvp1p, P40959; Sc Grd19p, Q08826; Sc Vps5p, Q92331; Sc YJL113C, CAA98681; Sc YDR425W, S69707; Sc YHR105W, S48947; Sc Vam7p, P32912) sorting nexins and human PI-3 kinase (Hs PI-3 kinase, JC5500). The domain architecture of the sorting nexins is shown at right. Gray boxes, PX domains; white circles, coiled-coil domains.
Both the human and yeast genomes contain moderately large families of sorting nexins (Teasdale et al., 2001; Xu et al., 2001), but only three genes in the Arabidopsis genome have been annotated as sorting nexins. We extensively screened the Arabidopsis genome with all the available human and yeast sorting nexin sequences using the tBLASTn algorithm but did not identify any additional homologs. Therefore, the sorting nexin family in Arabidopsis is smaller and less diverse than in humans or in yeast (Fig. 5B).
To confirm the interaction between SRK and Brassica SNX1, GST alone or GST fused to wild-type or kinase-negative forms of the SRK29 kinase domain were bound to glutathione-Sepharose beads and then incubated with hexa-His-tagged SNX1. Kinase/SNX1 complexes were then eluted from the resin by addition of glutathione. Figure 6A shows that SNX1 was eluted from the resin only if kinase domain fusion proteins were present as bait. No SNX1 was detected in the glutathione elution fractions if the bait used was GST protein alone. Deletion analysis demonstrated that the PX domain of Brassica SNX1 was sufficient to mediate the interaction with SRK (Fig. 6B).
Brassica SNX1 binds to the kinase domains of SRK, SFR1, and CLV1 in vitro. A, Elution of SNX1 from affinity resins loaded with GST or MBP proteins alone or GST or MBP fused with the kinase domains of SRK29, SFR1, or CLV1. Both wild-type and kinase-inactive mutant forms of the SRK29, SFR1, and CLV1 kinase domains were tested. B, Interaction between the SRK kinase domain and the PX domain (amino acids 1–157) of Brassica SNX1. Hexa-His-tagged SNX1 was detected with an anti-HIS antibody. In some cases, multiple bands were detected presumably due to the presence of either breakdown products or incompletely synthesized recombinant SNX1. E1 and E2, Eluted fractions. SRK29kin, GST::SRK29kin; SRK29kinK561R, GST::SRK29kinK561R; SFR1kin, GST::SFR1kin; SFR1kinK555R, GST::SFR1kinK555R; CLV1kin MBP::CLV1kin; CLV1kinK720E, MBP::CLV1kinK720E. C, RT-PCR analysis of SNX1 expression. Calmodulin (CAM) and actin cDNA were also amplified as controls. R, Root; C, cotyledon; L, leaf; Se, sepal; P, petal; A, anther; O, ovary; St, stigma; –, no cDNA control.
Using the same approach, we were also able to demonstrate interactions between SNX1 and two other PRK kinase domains, from SFR1 and CLV1 (Fig. 6A). SNX1 interacted with both wild-type and kinase-negative forms of the SRK kinase domain, but this was not the case for SFR1 and CLV1 where only the wild-type or only the kinase negative forms interacted, respectively. It is not clear why such differences were observed, but the differences were clearly reproducible. The interaction of SNX1 with the kinase domains of three diverse receptors suggests that this protein may play a role in multiple PRK signal transduction pathways. This hypothesis is supported by the fact that SNX1 transcripts were detected in a wide range of Brassica organs (Fig. 6C).
In this study, we have investigated interactions between several cytoplasmic stigma proteins and the kinase domain of SRK. We show that a stigma-expressed Brassica homolog of KAPP interacts with, and is phosphorylated by, the kinase domain of SRK in vitro. KAPP was also shown to dephosphorylate SRK. These results, together with the observation that SRK is phosphorylated in vivo approximately 1 h after an incompatible pollination (Cabrillac et al., 2001), suggest that KAPP may play a role in SRK down-regulation, as has been proposed for CLV1 and FLS2 (Williams et al., 1997; Stone et al., 1998; Gomez-Gomez et al., 2001). KAPP may not be the only protein phosphatase involved in the SI response because a breakdown of SI has been observed in pistils after treatment with okadaic acid or microcystin LR (Rundle et al., 1993; Scutt et al., 1993). Note, however, that okadaic acid and microcystin LR are inhibitors of type 1 and type 2A phosphatases and would not be expected to inhibit type 2C phosphatases such as KAPP.
Four previously unidentified interacting proteins were recovered by a two-hybrid screen carried out to search for new SRK-interacting proteins. One of these interactors, calmodulin, was of interest because it is known to be a component of many signal transduction pathways in both plants and animals (Sanders et al., 1999; Chin and Means, 2000). Calmodulin has been shown to interact with two animal receptor kinases: the epidermal growth factor receptor (EGFR) and the insulin receptor (Graves et al., 1985; San José et al., 1992; Joyal et al., 1996; Martín-Nieto and Villalobo, 1998; Feinmesser et al., 1999). However, the role of these interactions is not yet clear. Autophosphorylation of purified rat (Rattus norvegius) liver EGFR was inhibited by calmodulin in vitro, suggesting a direct role for calmodulin in down-regulation of the EGFR (San José et al., 1992). In contrast, the kinase activity of human EGFR, overexpressed in murine fibroblasts, was not inhibited by calmodulin binding (Martín-Nieto and Villalobo, 1998). However, binding of calmodulin may also have more subtle effects because it is known to regulate intracellular trafficking of EGFR (Tebar et al., 2002), and this regulation is thought to be mediated, at least in part, by its antagonistic effect on phosphorylation of EGFR by protein kinase C.
Calcium fluxes have been measured in both the cytoplasm and in the cell wall of stigmatic papillar cells after both compatible and incompatible pollination (Dearnaley et al., 1997; Elleman and Dickinson, 1999). These fluxes are associated with the region of the cell that contacts the pollen grain, and small, localized peaks in cytoplasmic calcium concentration have been correlated with subsequent hydration of pollen grains in B. napus (Dearnaley et al., 1997; Goring, 2000). Therefore, a possible role of calmodulin in vivo might be to mediate cross talk between calcium signaling occurring during pollination and SI signal transduction.
In addition to SRK, calmodulin interacted in a calcium-dependent manner with the kinase domains of three distantly related PRKs (SFR1, RLK4, and CLV1) but not with the kinase domain of BRI1. This suggests that calmodulin may interact with a broad range of PRKs.
A short region from within sub-domain VIa of the SRK kinase domain resembled a calmodulin-binding site based on its predicted amphiphilic α-helical structure, and this region was shown to bind calmodulin when fused to the C terminus of GST. Amphiphilic helices are predicted to occur in the subdomain VIa regions of SFR1, RLK4, and CLV1 but not BRI1, indicating a correlation between the presence of an amphiphilic helix and the ability to bind calmodulin. Sub-domain VIa is located close to the predicted ATP-binding site and the activation loop of the kinase domain, and this region is thought to play a structural role in PRKs (Torii and Clark, 2000). Interestingly, in the Arabidopsis Landsberg erecta mutant, a highly conserved hydrophobic residue (Ile-750) in sub-domain VIa of the ERECTA receptor kinase is replaced by a positively charged Lys residue (Torii et al., 1996). Secondary structure predictions indicate that ERECTA, like SRK, possesses an amphiphilic helix in this region of the kinase domain (even if the helix is less clearly predicted than that of SRK) and the replacement of Ile-750 by a Lys is predicted to modify the amphiphilicity of this putative helix. It would be interesting to determine whether this mutation affects binding to calmodulin.
The interaction observed between SRK and Brassica SNX1 is of particular interest because sorting nexins have been implicated in the down-regulation of animal receptor kinases. Several members of the sorting nexin family have been shown to interact with RTKs or RSKs both in vitro and in vivo (Kurten et al., 1996; Haft et al., 1998; Chin et al., 2001; Parks et al., 2001; Phillips et al., 2001) and modification of the rates of internalization and degradation of the EGFR and the platelet-derived growth factor receptor have been observed after overexpression of sorting nexins (Kurten et al., 1996; Phillips et al., 2001).
In yeast, the SNX1 homolog Vps5p/Grd2p is part of the retromer complex that is essential for retrograde transport from the endosome to the Golgi (Seaman et al., 1998). In addition to Vps5p, the retromer complex includes Vps26p, Vps29p, Vps35p, and Vps17p, and human orthologs of the first three of these proteins have been shown to form a complex that includes SNX1 (Haft et al., 2000). Moreover, human SNX1 reversibly associates with a specific endosomal compartment, again indicating a role in protein trafficking (Kurten et al., 1996, 2001; Teasdale et al., 2001).
Apart from the PX domain, no other sequences are widely conserved in sorting nexins (Teasdale et al., 2001). It is, therefore, significant that the similarity between the Brassica and human SNX1 proteins extends outside the PX domain, indicating that the two proteins carry out a similar function. Interestingly, the Arabidopsis genome is also predicted to encode orthologs of the retromer complex proteins Vps26p (accession no. Q9T091), Vps29p (CAB41864), and Vps35p (NM_127333). Plants, therefore, potentially possess all the components of a sorting nexin-based, vesicle trafficking system. It is possible that KAPP, which plays an important role in the internalization of AtSERK1 (Shah et al., 2002), interacts functionally with such a system to mediate PRK endocytosis.
In contrast to previous studies, which have indicated that plant and animal receptor kinases interact with structurally distinct sets of cytoplasmic proteins (Bower et al., 1996; Gu et al., 1998; Stone et al., 1998; Trotochaud et al., 1999; Schlessinger, 2000), we show here that SRK interacts with two proteins, calmodulin and SNX1, that are closely homologous to animal receptor kinase interactors. It has been proposed that the evolution of membrane-spanning receptor kinases occurred independently in plants and animals, perhaps coinciding with the evolution of multicellularity (Shiu and Bleecker, 2001; Cock et al., 2002). If this was the case, then the interactions with calmodulin and SNX1 in plants and animals were either acquired by convergent evolution, or these proteins already interacted with the common ancestor of plant and animal receptor kinases, which is thought to have been cytosolic (Shiu and Bleecker, 2001). Further analysis of the function of calmodulin and SNX1 in the regulation of receptor kinases in these two kingdoms should help distinguish between these two possibilities.
Cloning the Brassica oleracea Homolog of KAPP
An internal fragment of the Brassica KAPP coding sequence was amplified from a stigma cDNA library in the yeast (Saccharomyces cerevisiae) two-hybrid vector, pAD-Gal4 2.1 (see below), using two oligonucleotides, Kap1 (5′-GGAGGGATCCCAAGTTGGCTGTTCCTGGAAGTCAT-3′) and Kap2 (5′-CGCTGGATCCGGAAGTTTCCTGCCTCCTCGACGCAT-3′), based on the Arabidopsis KAPP gene sequence. Overlapping fragments corresponding to the 5′ and 3′ ends of the KAPP cDNA were then amplified using the two above oligonucleotides and two additional Brassica KAPP oligonucleotides, Kap3 (5′-TGGGCTTCAATTTGCTGTTCACTCC-3′) and Kap4 (5′-GGGATCTGAGGCCACACCAACT-3′), in combination with vector oligonucleotides from a second stigma cDNA library (Giranton et al., 1995) using a nested PCR amplification approach. Multiple cloned PCR fragments were sequenced to obtain the final definitive cDNA sequence.
cDNA Library Construction and Yeast Two-Hybrid Experiments
Total RNA was extracted, using the method described by Cock et al. (1997), from 600 stigmas of a B. oleracea line homozygous for the S3 SI haplotype (Delorme et al., 1995). A cDNA library was constructed from poly(A+) RNA in the HybriZAP vector (Stratagene, La Jolla, CA). Gene fusions of KAPP and ARC1 sequences with the Gal4 activation domain (Gal4AD) were constructed in pACT2 (CLONTECH, Palo Alto, CA). All gene fusions with the Gal4 DNA-binding domain (Gal4DB), including the kinase domains of SRK29 (amino acids 469–854; accession nos. T14519, 30) and SFR1 (amino acids 469–850; accession nos. T14519, 31), the KI domain of Brassica KAPP (amino acids 110–314), and the C-terminal domain of Brassica ARC1 (amino acids 36–661), were constructed in pAS2 (CLONTECH). Mutant kinase domains lacking kinase activity (SRK29K561R and SFR1K555R) were prepared with the Quickchange express kit (Stratagene).
For two-hybrid assays, yeast strains PJ69-4A (James et al., 1996) and Y190 (Flick and Johnston, 1990) were cotransformed using a lithium acetate-based protocol (Gietz et al., 1992) and grown on standard media (Anonymous, 2001).
Protein Expression and Purification
Gene fusions of the wild-type and mutant kinase domains of SRK29 and SFR1 with GST were constructed (Mazzurco et al., 2001; this work) in pGEX vectors (Pharmacia Corporation, North Peapack, NJ). The kinase domains of RLK4, BRI1, CLV1, and a kinase-negative form of CLV1 were expressed in Escherichia coli as fusion proteins with either MBP (for RLK4 and CLV1) or with GST (for BRI1). The fusion protein GST::KAPP included full-length Brassica KAPP without its signal peptide. GST::HEL1 included a fragment of sub-domain VIa of the SRK3 kinase domain (codons 617–643). A similar fusion protein carrying a non-helical, nonamphiphilic peptide of the same size and of similar hydrophilicity was called GST::PEP1. Expression of GST fusion proteins in E. coli and purification on a glutathione-Sepharose column were as described (Mazzurco et al., 2001), except for GST::SRK29K561R, which was grown at 20°C. Hexa-His-tagged Brassica SNX1 and its deleted form (codons 1–157 including the PX domain) were constructed in pQE32 (Qiagen S.A., Courtaboeuf, France) and expressed as described (Channelière et al., 2002).
Recombinant baculovirus containing the hexa-His-tagged Brassica calmodulin 2 was obtained with the Bac-to-Bac baculovirus expression system (Invitrogen, Carlsbad, CA). Hexa-His-tagged wild-type and kinase-negative forms of the mSRK3 (SRK3His and SRK3His) and Brassica calmodulin 2 were expressed in insect cells as described (Giranton et al., 2000). Calmodulin 2 was purified on nickel-nitrilotriacetic acid agarose beads (Qiagen S.A.).
Purified GST::kinase fusion proteins (2 μg in 300 μL) were incubated in 50 mm HEPES (pH 7.4), 150 mm NaCl, 1 mm dithiothreitol (DTT), 5 mm CaCl2, and antiprotease cocktail (Boehringer Ingelheim GmbH, Ingelheim am Rhein, Germany) with 100 μL of calmodulin-agarose resin (Sigma, St. Louis) for 1 h at 4°C in Eppendorf tubes with gentle agitation. The resin was washed with 40 column volumes of the binding buffer, and proteins eluted in 50 mm HEPES (pH 7.4), 150 mm NaCl, 1 mm DTT, 5 mm EGTA, and antiprotease cocktail were detected by immunoblotting using an anti-GST antibody (Pharmacia Corporation). Before carrying out the calmodulin-binding assay, mSRK3His expressed in insect cells was solubilized in 62.5 mm Tris-HCl (pH 6.8), 2.5% (w/v) SDS, 0.13 m DTT, and 20% (w/v) glycerol by heating at 100°C for 10 min and desalted twice on Bio-Gel P6-DG columns (Bio-Rad, Hercules, CA).
For kinase domain affinity-binding assays, 1 μg of GST::SRK29kin or GST::SRK29kinK561R was bound to glutathione-Sepharose beads (100 μL) and then incubated with 2 μg of Brassica calmodulin. Washing and elution were as above, and proteins were detected on silver-stained SDS-PAGE gels.
Binding to SNX1 was detected by incubating E. coli extracts containing equivalent amounts of soluble, recombinant GST- or MBP-kinase domain fusion proteins in affinity lysis buffer (50 mm HEPES [pH 7.4], 150 mm NaCl, 10 mm EDTA, 1 mm DTT, and antiprotease cocktail) with 25 μL of glutathione-Sepharose (Amersham Pharmacia Biotech Inc., Piscataway, NJ) or amylose-Sepharose resin (New England BioLabs, Beverly, MA), respectively. The resin was washed once with affinity wash buffer (50 mm HEPES [pH 7.4], 150 mm NaCl, 10 mm EDTA, and 1 mm DTT) and then incubated with E. coli extracts containing recombinant hexa-His-nexin fusion proteins in affinity lysis buffer. After washing with 120 column volumes of affinity wash buffer, fusion proteins and their interacting partners were eluted twice with 25 μL of either 10 mm glutathione, 10 mm Tris (pH 8), or affinity wash buffer plus 10 mm maltose. All experiments were repeated at least once.
Phosphorylation and Dephosphorylation Assays
Phosphorylation assays were carried out using either the procedure described by Williams et al. (1997) or, when using microsomes, that of Cabrillac et al. (2001). KAPP phosphatase activity was detected as described by Williams et al. (1997) using radiolabeled, autophosphorylated GST::SRK29kin prepared using the procedure described by Giranton et al. (2000).
Sequence Analysis and Secondary Structure Predictions
Sequence data analysis and construction of multiple sequence alignments were carried out using Lasergene sequence analysis software (DNASTAR, London). Neighbor joining trees were constructed from multiple alignments using ClustalW (Thompson et al., 1994) and NJplot (Perrière and Gouy, 1996). Secondary structure was predicted using a panel of programs available at the Web site of the Pôle Bio-Informatique Lyonnais (http://npsa-pbil.ibcp.fr/cgi-bin/npsa_automat.pl?page=npsa_sspred.html).
Reverse Transcriptase (RT)-PCR and RNA Gel-Blot Analyses
Total RNA was isolated from a range of different organs of B. oleracea line P57Si using the method described by Cock et al. (1997). RT-PCR and RNA gel blot experiments were carried out as described by Channelière et al. (2002).
Distribution of Materials
Upon request, all novel materials described in this publication will be made available in a timely manner for noncommercial research purposes, subject to the requisite permission from any third party owners of all or parts of the material. Obtaining any permissions will be the responsibility of the requestor.
We thank Shahinez Madi, Claire Rollin, Anne-Marie Thierry, Hervé Leyral, and Claudia Bardoux for technical assistance; Masao Watanabe for the SRK29 cDNA clone; and Daphne Goring, Erin Morris, John Walker, Steve Clark, and Steve Clouse for various PRK domain expression constructs. We are grateful to Gwyneth Ingram for her comments on the manuscript.
Article, publication date, and citation information can be found at www.plantphysiol.org/cgi/doi/10.1104/pp.103.023846.
↵1 Present address: Swann Building, Institute of Cell and Molecular Biology, King's Buildings, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK.
↵2 Present address: Unité Mixte de Recherche 7139, Centre National de la Recherche Scientifique-Goëmar-Université Paris 6, Station Biologique, Place Georges Teissier, BP 74, 29682 Roscoff Cedex, France
Received March 19, 2003.
Revised April 15, 2003.
Accepted June 23, 2003.
Published October 10, 2003.
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Plant Physiology Oct 2003, 133 (2) 919-929; DOI: 10.1104/pp.103.023846
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THE ART OF SJ39
NFL CAREER
St. Louis RamsSJ39.com Staff2016-12-07T08:05:16-08:00
FROM ROOKIE TO FRANCHISE-LEADING RUSHER
GAMES PLAYED (2004-2012)
RUSHING YARDS (FRANCHISE BEST)
RUSHING TOUCHDOWNS
In the 2004 NFL draft, Steven Jackson was the first running back selected, going 24th overall to the St. Louis Rams. He was selected as the heir apparent to Rams great Marshall Faulk, and struggled early to accept his role as understudy. His outspoken nature caused some people to see him the wrong way, but as he told Sports Illustrated in 2007, it was just a matter of wanting to do his part.
"People thought it was the Keyshawn Johnson 'give me the damn ball' cliché, that I was demanding the same respect as a Hall of Famer," he said. "That wasn't it. I just wanted to contribute."
He finished his rookie season with 643 yards and 4 touchdowns, and 19 receptions for 189 yards. It had become clear that Faulk was nearing the end of his career, so just one month after the end of the season the Rams announced the second-year back would assume the starting role.
Steven was also making moves in another area of his life. He founded the Steven Jackson Foundation for Literacy and Education, an organization started to help give youngsters educational opportunities, and reduce the dropout rate in local high schools.
"We all have dreams and aspirations, but how many of us really have the opportunity to make them come true," he told the Las Vegas Review-Journal. "It's great to have them and to work toward them, but everybody needs a Plan B. That's why having an education is important."
Steven registered his first thousand-yard season of his young career in 2005, totaling 1,046 yards, but he still felt as though he hadn't shown his true capabilities.
Part of that was due to the fact his coach, Mike Martz, utilized predominantly spread formations, leaving little blocking for a runner to do much between the tackles.
Martz left after the 2005 season, and the organization hired Vikings offensive coordinator Scott Linehan as his replacement. He had a reputation for building outstanding running attacks, including units that finished in the top five two out of his three years in Minnesota. Linehan stated from the beginning that Jackson would be the focal point of the offense, and would see his workload increase.
The result was a coming out party for the newest star in the NFL. SJax had a breakout season in 2006, rushing for 1,583 yards, and catching 90 balls for 806 yards, both franchise records. He had established himself as one of the premier backs in the game, and a fantasy owner's dream.
The league and his fellow teammates took notice, voting him an All-Pro, Pro Bowler, and Rams MVP.
"It means a lot because your peers picked you — your teammates," Jackson said of being named Rams MVP. "But it's kind of funny because without those guys, I couldn't have put the year together that I did put together. There's a lot of guys that are really deserving of the award."
The 2007 season saw SJ post his third-straight thousand-yard season, despite being limited to just 12 games due to injuries.
In the 2008 offseason, Steven signed a mutli-year contract to remain with the Rams, solidifying himself as one of the top backs in the league. He has returned to form, and is poised to remain of the premier players in the game for years to come.
He played in 12 games again during the 2008 season, but still managed to cross the 1,000-yard mark on the ground for the fourth straight season. He finished with 1,042 rushing yards and added 40 catches for 379 receiving yards, third on the team. He also scored eight touchdowns during the season and was well on his way to breaking Rams rushing records as he entered the second year of his new deal.
SJ39 was also excelling off the gridiron. Prior to the 2009 season, Steven made his first foray into filmmaking when he released the web documentary "In the Life" a three-part look at his life and the path that led to him becoming one of the NFL's brightest stars. The documentary drew rave reviews for its unprecedented depth and access to the personal life of a pro athlete.
Following up on his interactive success, 2009 would go down as one of Steven's best seasons yet on the field as well. In making his second Pro Bowl, SJ39 crossed the 1,000-yard barrier for the fifth straight year, breaking the team's previous streak held by all-time great and Hall-of-Famer Eric Dickerson.
"It's an amazing feat to have and I want it to keep going for as long as I'm a starter in this league, I can continue to be consistent and show my consistency and my hard work," Steven said. "I share this with my offensive line and my fullback as well."
Despite a herniated disc in his back that hindered him over the final six weeks of the season and forced him to miss the Pro Bowl, Steven rushed for a grand total of 1,416 yards in 2009 to win the NFC rushing title. He finished second in the NFL in yards on the ground. In addition, No. 39 continued to be a valuable threat to catch the ball out of the backfield as he hauled in a team-high 51 balls for 322 yards.
MAKING RAMS HISTORY
Following the season, SJ39 underwent surgery to repair the back injury and he entered the 2010 season revitalized, ready to take the Rams back into playoff contention.
He did just that, eclipsing 1,000 yards on the ground for a sixth straight season, a mark reached by just 10 other running backs in NFL history. With his sustained success and the durability and strength to play in all 16 games, came another Pro Bowl berth, the third of the young running back's career.
But the mark that Steven was most proud of fell on October 24th in Tampa Bay. On a three-yard run off right guard in the second quarter of a game against the Buccaneers, SJ39 passed Dickerson to move into first on the Rams career rushing list with 7,248 yards.
"It's something that I've worked really hard for, for a long time," Steven said. "So, to be able to achieve it, it means a lot."
During the final week of the 2010 season, Steven made another move that sent waves over the web, releasing another documentary "In the Life" series, this time documenting his recovery from the end of one game to the start of another. The documentary was filmed over the seven days between a Week 10 game with the San Francisco 49ers and a Week 11 game with the Atlanta Falcons.
The film once again gave unprecedented access to SJ39, including never before seen details about his recovery and rehabilitation, his relationships with teammates and coaches, moments with family, and more. The documentary series earned a Webby nomination for Best Online Sports video competing with ESPN, the Los Angeles Times, Major League Baseball and the Onion in the category.
While Steven was finding individual success, he was also helping his team visit the win column with renewed consistency. After winning just one game in 2009, the Rams picked up six on that number in 2010, winning seven games. They entered the final week of the season 7-8 with a chance at the NFC West title.
THE END OF THE RAMS ERA
Though they lost their season finale showdown with Seattle, hope sprung from defeat for St. Louis.
What once seemed years away was suddenly attainable, and with Steven leading the way, the Rams were back in the hunt for the NFC West title and a playoff berth.
The Rams entered the 2011 season confident in what the franchise had built and within reach of the success that each of them yearn for.
"Guys are motivated by how close we came in 2010, especially guys that were here last year," S-Jax wrote in a preseason blog entry. "Seeing how close we were to winning our division, going to the playoffs and hosting a game against the New Orleans Saints, that catapulted us into the offseason. It motivated every guy to come out this year and work to advance ourselves from a 7-9 team. Coming from 1-15 to 7-9, we've definitely made some great strides. Now it's time to win those games that maybe we were too young, or not experienced enough in winning, to closeout last year. We had a lot of close games last year and we should be able to win those games now."
While the Rams were on the rise, so were No. 39's off the field pursuits. In the offseason, SJ39 was named one of the "Vegas Dozen" for his charitable efforts in his hometown of Las Vegas and for his on field pursuits he was selected to the Southern Nevada Sports Hall of Fame. In addition, Steven was featured in ESPN the Magazine's third annual Body Issue, the only NFL player to receive the unique distinction.
Copyright of STEVEN JACKSON / Produced by ATHLETE INTERACTIVE | {
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WATERFRONT RESORT LIVING STYLE AT "AQUARIUS". Best possible & desirable floor plan (02) with generous size of kitchen, living/dining & eating area, all overlooking marina, seawall & False Creek professional upgraded finishing includesnew crown moulding, Brazilian cherry flooring throughout, hidden wired audio-visual. WASH-U-let bathroom, Murphy bed in 2nd bdrm, fresh paint & some new appliances. This unit has a nice size balcony. Limo size parking & a huge 14'x7' U/G storage locker. Full "Heath CLUB" & 24 hour concierge. Just few steps from "ROUNDHOUSE, URBAN FAIR & all amenities. | {
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Discussion in 'Mac OS X Server, Xserve, and Networking' started by macridah, Feb 5, 2006.
Will the xServer be transitioning to intel chips as well? Will it be 64 bit?
any chance we will find woodcrest in the desktop (aka mac pro)?
Woodcrest is a codename. If Intel follows their past behavior, its official name will be Xeon. However, I wouldn't be surprised if they change, since they dropped the Pentium name for CoreDuo.
ok, Im an Intel Noob. Whats the difference between Itanium and Xeon. Arent they both built for servers and workstations?
They share the same target audience (more or less) - servers and workstations, as you say.
I don't think you will ever see an Itanium in a Mac. | {
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Соревнования по лыжным гонкам в эстафете 4×5 км среди женщин на зимних Олимпийских играх 2022 года прошли 12 февраля. Местом проведения соревнований стал Национальный лыжный центр расположенный в долине на северо-востоке от деревни Тайцзичэн, района городского подчинения Чунли города Чжанцзякоу провинции Хэбэй. Гонка началась в 15:30 по местному времени (UTC+8). Первые два этапа участники шли классическим стилем, а третий и четвёртый — свободным.
Чемпионками Олимпийских игр 2018 года в женской эстафете являлись норвежские лыжницы, на этот раз команда Норвегии заняла пятое место (из чемпионок 2018 года за них бежала только Рагниль Хага).
Золото завоевали лыжницы команды из России, выступавшие под флагом ОКР, вторыми с отставанием в 18,2 сек стали немки, третье место заняли шведские лыжницы, проигравшие чемпионкам 20,7 сек. Для всех лыжниц команды ОКР эта медаль стала первой золотой на Олимпийских играх, а для Татьяны Сориной и Вероники Степановой вообще первой олимпийской.
Медалисты
Результаты
Ссылки
Лыжные гонки на официальном сайте зимних Олимпийских игр
Олимпийский турнир на официальном сайте Международная федерация лыжного спорта (FIS) | {
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Building Civic Education in Bosnia
During the summer of 1996, American and European teachers participated in the Civitas program described in the previous article. Its aim is to train Bosnian teachers in the use of curricular materials and methods promoting education for democracy. Among the American teachers who visited Bosnia in July to train their Bosnian colleagues were Pat Feichter, Gail Huschle and Mary Bristol. Here, they share some of their memories with the readers of Social Education. Their visit was organized by the Center for Civic Education of Calabasas, California, with the support of the United States Information Agency.
Would I Return? In a Heartbeat!Pat FeichterMaine South High SchoolPark Ridge, Illinois
When the Center for Civic Education asked me to volunteer to teach in Bosnia this summer, I jumped at the opportunity. Many people thought I was crazy, but I knew it would be a unique experience and one in which I could make a positive contribution in promoting democratic values.Entering Bosnia, it does not take long to experience destruction. Our seven hour bus trip to Sarajevo passed through dozens of war ravaged villages and towns. Some were selectively damaged, with only certain areas felled by artillery shells, while others were totally leveled. The once beautiful city of Mostar was one of the worst damaged. Everywhere in this Muslim-Croatian divided city there was evidence of war.Sarajevo, once the proud host of the 1984 Winter Olympic Games, is a city of burnt-out hulks. Over 1,300,000 artillery shells have struck Sarajevo. The effects were extensive and devastating. The Holiday Inn, where we stayed while in Sarajevo, is still marked by the effects of war. There are elevators and guest rooms with bullet holes and a stairway being repaired from a direct artillery hit.I was assigned to teach in the Canton of Travnik, 60 miles north of Sarajevo. I worked with one other American teacher and two Europeans, one from Germany and the other from Switzerland. This was the first time any of us had worked together. Flexibility and a willingness to compromise was a basic need. We were able to work together well.Our class had thirty participants. These were teachers of Muslim, Croatian, and Serbian background. We worked entirely through interpreters. Our facility was a Jesuit-founded secondary school 114 years old.Apprehension is the best way to describe our feelings going into this two-week course. Would the class understand us? Would they like us? Would they be willing to participate in simulations and group projects? The answer to this was a resounding yes!The Bosnian teachers, our students, were a joy to work with. They had a great sense of humor and an incredible interest in learning about democracy. Our mock trial and simulated election were two of the most popular activities. We became so close to members of our class that we were frequently invited to their apartments.People often ask me if I was frightened being in Bosnia. The answer is no. As long as you used common sense, there was nothing to fear. I walked the streets of both Travnik and Sarajevo in the evenings without a worry. However, you could not plan picnics in the countryside. An estimated 8 to 11 million landmines are a danger. You must stay on paved roads and sidewalks.One of the saddest effects of the war is the huge number of refugees living in squalor. They have very little food to eat. One man showed me a small piece of goat cheese, which was his only allotment of food for the day. These displaced people have in many cases been living in refugee centers for more than two years, and often don't know where their loved ones are or even if they are alive. The most we could do for them was to offer clothes, some food, and a small amount of money.Ethnic tensions do exist in Bosnia and are usually just below the surface. One evening on the streets of Travnik, I was approached by an irate group of Croatians. They were very upset because the person who selected the Bosnian teachers to attend our program was a Muslim. They were concerned about bias in the selection process. From time to time, we would hear stories about churches and mosques being bombed. Ethnic tensions are a fact of life in Bosnia.Would I return? In a heartbeat! Working with the Bosnian teachers was one of the most rewarding experiences of my life. In a small way I feel I may have helped further democracy and peace in this troubled land. n
Beauty in the Midst of Devastation
Gail HuschleSt. Croix Catholic SchoolStillwater, Minnesota
When I remember my three weeks in Bosnia-Herzegovina, it is not the amazing physical beauty of the country nor the irony of that beauty contrasted with the terrible devastation of the towns which haunt me. Rather, it is the bond I formed with two remarkable women, Hajra Alibegovic and Azemina Masinovic. As we sat for one last cup of Turkish coffee in the Sarajevo Bashtasherie (Head Market), they asked me one last question: "After what you have seen here, do you feel we are foolish to want to forgive and forget?" Did I answer them "correctly?" I don't know.First, I should tell you about these two women. Hajra was my alter-ego, my translator. By the time two weeks had passed, she could anticipate what I would say next, often using the same inflection and hand gestures. She and her husband stayed in Travnik even though they might have fled. They were a secular family. They saw themselves as Bosnians first, not as members of an ethnic or religious group. They did send their two daughters abroad to study. Their younger daughter, Samra, served as our German translator; she hadn't been home for four years. I tried to imagine what it must have been like to miss the formative teen years of your child. Unimaginable. Hajra and her husband remained because, as the only English teacher, Hajra could not leave her students-all of whom maintained that she was the best teacher they ever had. As a psychiatrist, Hajra's husband could not leave his patients, many of whom bear the burdens of life in the military. This couple had links to Croatia, including a comfortable family home in Dubrovnik, yet they chose to stay in Travnik because they identify themselves as Bosnian. After their beautiful home on Vlashish Mountain was destroyed by the Serb forces, they found a small flat in town in which to withstand the four years of merciless shelling. Some of the blasts landed just a few feet from their building. Hajra somehow makes a positive out of this negative. She says she is liberated from the material things of life and now values friends and family more than ever. Perhaps that's why she gave me a lovely piece of lace handiwork from her own collection, and slipped a silver bracelet onto my wrist as we parted, saying, "There, now you must return because you are my sister!"Azemina is Hajra's best friend. She is Muslim. Correction! She is a Bosnian who lives as a Muslim in faith. Her husband's family has lived in Travnik for over 100 years. Her daughter was married in Germany during the war; she could "attend" through photos alone. I was invited to share a meal with Azemina and Hajra at Azemina's home. There we shared "pita," strawberry juice, and Turkish coffee. Azemina is an expert in the tedious art of making filo dough which encases the spicy meat of "pita." The men stopped by to invite us to walk around town in the nightly social promenade, but Azemina and I conspired to keep our evening only for the ladies. She told them my left leg hurt so that we could continue the talk of children, husbands, and weddings. She gave me Muslim prayer beads as I left to remind me of her whenever I prayed a rosary, since I am Roman Catholic.Throughout the two weeks, these women made me understand Bosnian hospitality. Both took delight in their shared culture; both took pride in the traditions of the other. Neither has patience for split national designations: Bosnian-Croats or Bosnian-Serbs or Bosnian-Muslims. Both want Bosnia for Bosnians.So, what was my answer to their last question? Are they foolish to forgive and forget the harms done in the last four years? No, I said, to take sides is to negate the nobility that your friendship signifies. To take sides is to make the idea of Bosnia-Herzegovina obsolete. n
Making Connections Between Cultures
Mary BristolAnchorage School District, Alaska
"We now have clean air and empty pockets." This was how the residents of Zenica described the effects of the steel plant not operating there. High unemployment and buildings in need of maintenance were signs of war time difficulty. The vegetable gardens on the lawns of our hotel attested to the struggle for survival. Although predominantly Muslim, many residents spoke of the desire for an ethnically diverse and united Bosnia-Herzegovina as they offered us warm hospitality.Participants in our seminars were well prepared and actively involved. While their community has many pressing needs, it was evident they have a strong commitment to civic education. Class discussions were intense and questions were pertinent. They embraced new content and methods such as mock trials and town meetings. Participants vacillated between optimistic planning and confronting difficult realities.Our study of constitutionalism, authority, justice, and the role of the citizen in a democracy elicited powerful responses. Discussion of civic responsibility led to the sharing of experiences. One teacher told of observing a colleague stealing petroleum vital to the war. She struggled to determine what her responsibility was in those circumstances. Another recounted rescuing his mother from a war zone. He described his search, their hunger, and them walking many kilometers and crossing a mountain. Another explained that few had survived the sniper fire while ascending that particular mountain. It put my experiences in perspective.To provide practice in policy-making, we used Project Citizen, the program designed by the Center for Civic Education to help middle school students learn to work together with their communities on issues of public policy. As teachers identified community problems, it was clear that some-such as environmental issues, welfare, and educational concerns-are universal. Language differences meant that observing body language and obtaining translations of daily written summaries became important tools. As groups began working, I realized how much I normally use conversations to guide questions and evaluate progress. Awareness of different patterns of inter-cultural communication, especially of distinct speech and politeness systems, was essential to productive teaching. I used listening tools intensely. Our Bosnian colleagues spoke in a unique pattern. First they would tell us what they would be saying, next they would say it, and finally they would summarize what was said. Once I understood this pattern, it was easier to listen for the pertinent information. I tried to modify my presentation but found it difficult to change.We tried diligently to show respect for each other. That meant slowing down as we worked to build understanding. I tried not to ask questions too soon. While Americans are informal and direct, our hosts asked questions only after much conversation about a topic. Each tried to observe the other for clues to politeness. When our host said, "We might consider going to the restaurant" and then pulled out another cigarette, we realized that the leaving ritual was long.Bosnia is complex, fragile and difficult to understand. Regardless, the connection with Bosnian teachers was strong. We want the same things for our students. We worry about their preparation and opportunities to contribute to society. That is the essence of teaching. | {
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Queens Theatre in the Park chooses new exec director
By Times Ledger
March 31, 2011 | 7:04pm
Executive Director Jeffrey Rosenstock, Queens Theatre in the Park has a new man at its helm.
Ray Cullom, the institution's choice for its new leader, brings 20 years of experience in arts administration, programming and production to the job, where he will oversee the venue, leading its artistic direction, finances and education programs as it moves into its third decade serving the borough.
Cullom started his tenure at the theater, located in a historic building in Flushing Meadows Corona Park, March 14 and he said he hopes to enhance and expand on the services the theater provides its audiences.
"This theater has a great history and has done wonderful things, and I hope to build upon that and elaborate on it," he said Tuesday. "What I would really love to do is fully use this venue. With its location and the great diversity and number of people that live within a short distance of the theater, this is a theater that should be more active several days a week. I hope to build the audience to include more of Queens and its surrounding communities."
Frances Resheske, president of the theater's board of directors, said in a statement that Cullom's experience will complement and enhance the theater's goals.
"He has done a remarkable job by setting both artistic and management vision at several institutions," Resheske said. "Our patrons and donors stand to benefit from Ray's leadership."
He said one of his key hopes is that he can lead the theater into a period where it draws new audiences who might not usually attend arts performances.
Cullom said Queens Theatre in the Park had great appeal to him because of its magnificent resources and its unique approach to both producing performances in-house and presenting outside works. Those assets were two of the key reasons he was drawn to Queens from his previous post as managing director of the Long Wharf Theatre in New Haven, Conn. Before that, Cullom served as executive director of the Bethesda Theatre in Bethesda, Md.
Rosenstock said he is proud of the work he did at QTIP.
"During my tenure, I led the transformation of an abandoned World's Fair building into a premier performing arts center," he said in a statement. "I am proud of our diverse programming and to have laid the foundation for future artistic development."
Rosenstock's final season of programming at the theater will wrap in the coming weeks, and the fall QTIP season will be the first led by Cullom, who said the calendar should be released by mid-May.
The theater recently completed a $27 million renovation and expansion that included the addition of a cabaret performance space and other amenities.
For more information or to see a schedule of performances, visit queenstheatre.org.
Reach reporter Connor Adams Sheets by e-mail at [email protected] or by phone at 718-260-4538.
[email protected]
LIC teacher tells story of rescuing son to 113th Pct. | {
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Fake Brands – Symbols of Affluence or Mere Folly?
Indecisive shopping attitude and uninformed (read impulsive) shopping sprees can end up in replicas of brand products – fake in the absolute sense. And when that is a high end label or a well-known international brand, much is at stake. Both for the buyer and the brand!
In one of my online shopping sprees, I came across a website offering Louis Vuitton's totes at a marginally low-'low' cost. The double emphasis on the word 'low' is unusual and so was the offer in question! The website claimed to be part of the LV factory outlet, offering bags, totes and backpacks at a discounted price of more than 70%.
By the virtue of being a Trademarks specialist (and a Louis Vuitton fan), I went ahead and bookmarked the website (http://www.louisvuttionsoutlet.org/) and decided to check its credentials, only to realize that the domain was registered in the name of one Lin Hong Hui from China.
China can, for several reasons, be termed as the counterfeit "workshop" of the world. Guangzhou in South China is the epicenter of the world's counterfeit trade, wholesaling fake leather goods and apparel across the globe. The US customs and Border Protection Agency conducted nearly 25,000 seizures of counterfeit goods in 2013 alone, of which nearly 70% of came from China.
With the growing demand of luxury products and the simultaneous growth of the counterfeits, fighting fakery has indeed become a tough battle.
In 2014, American border officials nabbed counterfeits worth $1.2 billion. Their European Union counterparts seized fake products worth €768m ($1 billion) in 2013. While these numbers may seem high, the reality is that these are just a fraction of the total counterfeits being peddled. Estimates for the total value of fake goods sold worldwide each year could go as high as $1.8 trillion.
The problem has aggravated as the business of counterfeits finds space in the virtual world. America's trade representatives predicted in April 2015 that online sales of pirated goods might exceed those in physical markets, adding that "Enforcement authorities unfortunately, face difficulties in responding to this trend. Online counterfeiters can stay anonymous, reach across borders and constantly launch new websites to evade legal action".
In 2013, C2C retailer Taobao Marketplace (founded by the Alibaba Group in 2003) signed an agreement in with Parisian luxury brand Louis Vuitton to establish a cooperation mechanism for IP protection. But the irony here is that till date, Taobao offers wide range of counterfeit Louis Vuitton bags and totes on its website.
Consumers and business owners both play complex roles here. Where few are always on the lookout for genuine products at discounted prices, others prefer them at marginally low prices. Some knowingly hunt for fakes and some are willing to pay the real price for a genuine product! The most troubling situation is for the brand owners, who either remain unwary or rather uninformed about the brand counterfeiting prevalent in the e-domain.
Spotting the difference is the key!
China's elite may have become too savvy for Louis Vuitton, but the luxury brand still remains popular among those who wish to own "branded" goods, albeit purchase them at a fraction of the original's price. But what happens, when you save up your savings to own a 'genuine' 'LV' and you end up with one which was manufactured at some local store at the Guangzhou district in China? With the growth of e-commerce platforms, counterfeits are just a click away! Spotting the difference and making an informed choice is the key to being a proud owner of the famous label.
Originals come with a price and value. Stay original, let the fakes fade away.
Brands such as Louis Vuitton have a value because of the high quality products they deliver. This means that the cost you pay is worth its shelf life. Support originals. Shun the fake.
Abhilasha's interest in brand protection landed her into a job as a legal expert in trademarks. From Trademarks Searches to Trademarks Portfolio Management, Trademarks Prosecution and Advisory and Protection and Enforcement of IP rights, she loves her brand-loving job. And when she's not blogging, you can smell appetizing bakes wafting out of her kitchen.
This blog is very helpful as its very difficult to differentiate branded stuffs, specially in Delhi where we have lot of fake products. | {
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ServiceWear Apparel can create a logo from scratch or digitize and re-work an existing image. We offer a wide selection of thread colors constructed from a 60% poly/40% cotton blend that ensures vibrancy as well as colorfastness. Browse our embroidery gallery. | {
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If you care about gay rights, you might want to rethink your drink.
Gay rights groups are boycotting Russian vodka after the country cracked down on gay activists and pride parades, the BBC reports. In addition, new legislation makes it illegal to teach "non-traditional values" (ie. gay-friendly values) to children.
On June 29, a gay pride parade in St. Petersburg was attacked by thugs and several marchers were badly beaten. Police then rounded up the marchers (not the thugs) and arrested them. You can see photos from this and related events in this shocking photo essay from Buzzfeed.
The boycott started in the U.S. a few days ago and has since spread to other countries. Gay bars have pulled Russian vodka from their shelves and an online petition is calling for Manchester to "untwin" from its sister city St. Petersburg. Protesters have dumped vodka on the street in front of the Russian consulate in New York City and taken to Twitter with hashtags such as #dumpstoli and #dumprussianvodka.
Homosexuality was decriminalized in Russia almost two decades ago but there's been a severe backlash against the LGBT community in recent years.
One major vodka brand, Stolichnaya, has come out with a public statement in support of gay rights and says it shouldn't be targeted by the boycott. They say that while they use Russian ingredients, they are in fact a Latvian company.
There's an ongoing discussion in the LGBT about expanding the boycott to include other Russian products and also the 2014 Winter Olympics in Sochi, Russia.
Places of worship have long been points of interest for travelers. Solemn and usually quite ornate, these buildings provide a window onto a community's history and values and often give visitors a much-needed pause while pounding the sightseeing pavement. Cathedrals are typical for this kind of touring. But have you ever thought to pay a visit to a synagogue?
My fascination with exploring synagogues began on a trip to Willemstad, Curaçao, home of Mikvé Israel-Emanuel, the oldest active Jewish congregation in the Americas built in 1651. Several years later, I had the opportunity to visit the Paradesi Synagogue in Cochin, Kerala, India. Constructed in 1568, it is the oldest "active" synagogue in India – "active" because there are fewer than 20 Jews left in Cochin, most having emigrated to Israel. Coincidentally, I learned about the Jews of Cochin from an exhibit at the 6th and I Synagogue, a historic synagogue in Washington, DC, that is now used primarily as a community center and arts space.
The Jewish diaspora is thriving in many parts of the world. Yet in places like Cochin and Mumbai, the local Jewish community is dwindling, giving impetus to visiting some synagogues before they are shuttered or left to become museums. The following are some of the synagogues I have seen or wish to explore on my travels.
From an island microslum in Colombia to a haute enclave in central Paris, the ten most crowded islands in the world bear scant similarities in class or culture. In fact, every entry in the top ten comes from a different country. But being islands, each shares the common thread of scarcity – whether it be land, resources, or housing. In general, these islands are prophetical microcosms for an overcrowded earth – finite spaces where self sufficiency governs and demand pierces supply.
With the world's population racing higher and higher, and the "megacities club" accepting new members yearly, some day the earth could bear the traits of one of these densely packed islands.
Story: This island located in St. Pete is a collection of 18th and 19th century buildings with some Soviet built apartment blocks lining the Gulf of Finland on the western shore. The communist housing ethos of the twentieth century called for rows and rows of tight apartments, and this historic island in Russia's second city was not immune to the sprawl. This created the compact quarters of Vasilyevsky island. Famous for its old school stock exchange and giant Rostral columns, the island is popular with tourists.
Story: This small island in central Stockholm once served as a hub of industry for Stockholm's industrial operations. The easy boat access allowed for ease of shipping by boat, and the island factories manufactured an array of goods, from massive lamps for lighthouses to vacuum cleaners. Eventually, as the industrial applications became outmoded, the island became home to several apartment towers. Today, the island is crammed full of smiling Swedes living in apartments with (presumably) tasteful modern furniture.
Story: Perhaps the most stylish island in the world, Île Saint-Louis is a marvel of 17th century urban architecture and planning. Narrow roads and some of the priciest real estate in the world have allowed the island to remain relatively calm, despite its location in central Paris. While Île Saint-Louis is off of the tourist radar for most, this island in the Seine River embodies the classic Parisian spirit, worthy of an afternoon stroll with a perfect sorbet from Berthillon. The island is named for France's canonized King, Louis IX.
Story: In 1626, the Lenape Indians sold Manhattan island to the Dutch for a bag of axes, hoes, iron kettles, duffel cloths and other 17th century garb worth about $24 (roughly $1000 in modern value). It is safe to day the island has grown ambitiously from this humble transaction. The center of the financial universe is now home to many – truly a place where the world lives. The island once known as New Amsterdam, and briefly, New Orange, shadows America's story, both tragic and triumphant.
Story: Salsette, an island off the western coast of India, is home to Mumbai and its sprawling suburbs. As a poster boy for "New India," Mumbai is as dichotomous as it gets, at once the wealthiest city in south Asia and also home to one of the world's largest slums – the notorious Dharavi. Dharavi is an island within an island, a super-slum with roughly one million people spread out over an area less than a square mile. At the other end of the spectrum, Salsette Island is also home to extreme wealth. The house known as Antilla is a 400,000 square foot giant that towers with some of Mumbai's tallest buildings. Truly a contrast from the squalor in Dharavi, the private residence houses six people, can accommodate 168 cars, has 9 elevators, and an ice room with snow flurries.
Story: The Maldives is one of Asia's top tourist destinations, with 26 atolls and 1,192 islands offering beach perfection. At its center is the capital city – Male. Male is a humbly sized island of just a couple square miles. It is stuffed full of people, hotels, mosques, and office towers that efficiently utilize the scare land resources. While landfills have reclaimed some land from the sea, most progress is made vertically rather than horizontally. The modern downtown island in the middle of the Indian Ocean is a stark aberration from the deserted islands that dot most of the Maldives.
Story: Hong Kong is the land of a thousand towers, clustered most densely on the island of Ap Lei Chau just southwest of Hong Kong Island. Ap Lei Chau served as the settlement for Hong Kong Village, theorized to be the etymological source for the famous larger territory of Hong Kong. Strangely, Ap Lei Chau translates to Duck Tongue Island, said to be named for the island's shape. It is filled with high rise residences and even a winery.
Story: This bantomslum in the middle of Lake Victoria is a fishing village perched precariously on half a sphere of rock. The residents take in large hauls of the Nile Perch – a poster boy for River Monsters that can grow to a comedically large size. Migingo is famous for a decades-old dispute between Kenya and Uganda over the sovereignty of the small island. There is even a facebook page where individuals can "like" declaring the island Kenyan. (The page has twice as many followers as there are residents on Migingo.) Uganda agrees with this claim, most of the time, though the tiny rock island is not the issue – the fishing rights are.
Story: The most densely populated island in the world is a microslum off the coast of Colombia. This tropical island is located in the emerald waters of the idyllic Caribbean, though is packed so tight that most activities are done off island. Schooling, football, graveyards, and work all take place away from Santa Cruz del Islote. The island park is the size of a small tennis court, and fresh water must be shipped in by Colombian Navy ships. Santa Cruz del Islote also does not have electricity. What the island favela does have is people, lots of them. To visit the world's most packed island, hop on a ferry from Tolu, Colombia. The nearby hotel of Punta Faro can arrange tours of the island.
This quick trip around the world by filmmaker and photographer Alex Profit is a stunning display of photo-tourism. The video embarks on a journey through Paris, Barcelona, Berlin, St. Petersburg, Shanghai, Tokyo, New York and London. It will cure your nagging fits of wanderlust for the duration of its five minute run-time. Beyond that though, you may experience an uncontrollable urge to visit Barcelona or one of the other many locales documented.
The video was made by compiling 2000 photographs from eight separate locations. It took Alex twenty-four days to travel to all of the locations and get the shots. That is covering a lot of ground, fast. If you could choose to travel to any of these locations, which one would you choose? | {
"redpajama_set_name": "RedPajamaC4"
} |
Covered in:
Influence of Non-Saccharomyces on Wine Chemistry: A Focus on Aroma-Related Compounds
Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications
Quantum mechanics, Neuroscience, and Fuzzy logic allied together for promoting Chemical Artificial Intelligence
Synthesis, Bioactivity, Pharmacokinetic and Biomimetic Properties of Multi-Substituted Coumarin Derivatives
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Abstract Page
Chemical Composition and Metabolomic Analysis of Amaranthus cruentus Grains Harvested at Different Stages
Tlou Grace Manyelo
Nthabiseng Amenda Sebola
Zahra Mohammed Hassan
Jones Wilfred Ng'ambi
William James Weeks
Monnye Mabelebele
Molecules 2022, 27(3), 623; https://doi.org/10.3390/molecules27030623 (registering DOI) - 19 Jan 2022
This study aimed at investigating the impact of early versus normal grain harvesting on the chemical composition and secondary metabolites of Amaranthus cruentus species grown in South Africa. Mature harvested grain had higher (p < 0.05) DM, CF, NDF and ADF content [...] Read more.
This study aimed at investigating the impact of early versus normal grain harvesting on the chemical composition and secondary metabolites of Amaranthus cruentus species grown in South Africa. Mature harvested grain had higher (p < 0.05) DM, CF, NDF and ADF content compared to prematurely harvested grain. There were no significant (p > 0.05) differences between CP, ADL and GE of premature and mature harvested grains. Mature harvesting resulted in higher grain Ca, P, Mg and K content. Essential amino acids spectrum and content remained similar regardless of maturity at harvest. The grains displayed an ample amount of unsaturated fatty acids; the highest percentage was linoleic acid: 38.75% and 39.74% in premature and mature grains, respectively. β-Tocotrienol was detected at 5.92 and 9.67 mg/kg in premature and mature grains, respectively. The lowest was δ-tocotrienol which was 0.01 and 0.54 mg/kg in premature and mature grains, respectively. Mature harvested grain had a higher secondary metabolite content compared to premature harvested grains. The results suggest that mature harvested Amaranthus cruentus grain contain more minerals and phytochemicals that have health benefits for human and livestock immunity and gut function, which ultimately improves performance. This study concludes that A. cruentus grown in South Africa is a potential alternative cereal to major conventional cereals. Full article
(This article belongs to the Special Issue Bioactive Phenolic and Polyphenolic Compounds-2nd Edition)
Detection and Risk Assessments of Multi-Pesticides in Traditional Chinese Medicine Chuanxiong Rhizoma by LC/MS-MS and GC/MS-MS
Delin Zhang
Yan Gou
Xingyu Yu
Mei Wang
Wen Yu
Juan Zhou
Wei Liu
Min Li
With the internationalization of traditional Chinese medicines (TCMs) and the increasing use of herbal medicines around the world, there are concerns over their safety. In recent years, there have been some sporadic reports of pesticide residues in Chuanxiong Rhizoma (CX), although the lack [...] Read more.
With the internationalization of traditional Chinese medicines (TCMs) and the increasing use of herbal medicines around the world, there are concerns over their safety. In recent years, there have been some sporadic reports of pesticide residues in Chuanxiong Rhizoma (CX), although the lack of systematic and comprehensive analyses of pesticide residues and evaluations of toxicological risks in human health has increased the uncertainty of the potential effects of pesticides exposure in humans. This study aimed to clarify the status of pesticide residues and to determine the health risks of pesticide residues in CX. The findings of this study revealed that 99 batches of CX samples contained pesticide residues ranging from 0.05 to 3013.17 μg/kg. Here, 6–22 kinds of pesticides were detected in each sample. Prometryn, carbendazim, dimethomorph, chlorpyrifos, chlorantraniliprole, pyraclostrobin, and paclobutrazol were the most frequently detected pesticides, with detection rates of 68.69–100%. Insecticides and fungicides accounted for 43.23% and 37.84% of the total pesticides detected, respectively. Here, 86.87% of the pesticide content levels were lower than 50 μg/kg, and a small number of samples contained carbofuran, dimethoate, and isofenphos-methyl exceeding the maximum residue levels (MRLs). A risk assessment based on the hazard quotient/hazard index (HQ/HI) approach revealed that the short-term, long-term, and cumulative risks of pesticide residues in CX are well below the levels that may pose a health risk. Worryingly, six banned pesticides (carbofuran, phorate sulfone, phorate-sulfoxide, isofenphos-methyl, terbufos-sulfone, and terbufoxon sulfoxide) were detected. This study has improved our understanding of the potential exposure risk of pesticide multi-residues in CX. The results of the study will have a positive impact on improving the quality and safety of CX and the development of MRLs for pesticide residues. Full article
LC-ESI-MS/MS Identification of Biologically Active Phenolics in Different Extracts of Alchemilla acutiloba Opiz
Katarzyna Dos Santos Szewczyk
Wioleta Pietrzak
Katarzyna Klimek
Anna Grzywa-Celińska
Rafał Celiński
Marek Gogacz
Liquid chromatography electrospray ionization tandem mass spectrometric (LC-ESI-MS/MS) qualitative and quantitative analysis of different extracts from the aerial parts and roots of Alchemilla acutiloba led to the identification of phenolic acids and flavonoids. To the best of our knowledge, isorhamnetin 3-glucoside, kaempferol 3-rutinoside, [...] Read more.
Liquid chromatography electrospray ionization tandem mass spectrometric (LC-ESI-MS/MS) qualitative and quantitative analysis of different extracts from the aerial parts and roots of Alchemilla acutiloba led to the identification of phenolic acids and flavonoids. To the best of our knowledge, isorhamnetin 3-glucoside, kaempferol 3-rutinoside, narcissoside, naringenin 7-glucoside, 3-O-methylquercetin, naringenin, eriodictyol, rhamnetin, and isorhamnetin were described for the first time in Alchemilla genus. In addition, the antioxidant, anti-inflammatory and cytotoxic activity of all extracts were evaluated. The results clearly showed that among analyzed extracts, the butanol extract of the aerial parts exhibited the highest biological activity comparable with the positive controls used. Full article
(This article belongs to the Special Issue Chromatographic Science of Natural Products II)
Supplementary File 1 (ZIP, 177 KiB)
DFT, ADMET and Molecular Docking Investigations for the Antimicrobial Activity of 6,6′-Diamino-1,1′,3,3′-Tetramethyl-5,5′-(4-chlorobenzylidene)bis[pyrimidine-2,4(1H,3H)-dione]
Nesreen T. El-Shamy
Ahmed M. Alkaoud
Rageh K. Hussein
Moez A. Ibrahim
Abdulrahman G. Alhamzani
Mortaga M. Abou-Krisha
Heterocyclic compounds, including pyrimidine derivatives, exhibit a broad variety of biological and pharmacological activities. In this paper, a previously synthesized novel pyrimidine molecule is proposed, and its pharmaceutical properties are investigated. Computational techniques such as the density functional theory, ADMET evaluation, and molecular [...] Read more.
Heterocyclic compounds, including pyrimidine derivatives, exhibit a broad variety of biological and pharmacological activities. In this paper, a previously synthesized novel pyrimidine molecule is proposed, and its pharmaceutical properties are investigated. Computational techniques such as the density functional theory, ADMET evaluation, and molecular docking were applied to elucidate the chemical nature, drug likeness and antibacterial function of molecule. The viewpoint of quantum chemical computations revealed that the molecule was relatively stable and has a high electrophilic nature. The contour maps of HOMO-LUMO and molecular electrostatic potential were analyzed to illustrate the charge density distributions that could be associated with the biological activity. Natural bond orbital (NBO) analysis revealed details about the interaction between donor and acceptor within the bond. Drug likeness and ADMET analysis showed that the molecule possesses the agents of safety and the effective combination therapy as pharmaceutical drug. The antimicrobial activity was investigated using molecular docking. The investigated molecule demonstrated a high affinity for binding within the active sites of antibacterial and antimalarial proteins. The high affinity of the antibacterial protein was proved by its low binding energy (−7.97 kcal/mol) and a low inhibition constant value (1.43 µM). The formation of four conventional hydrogen bonds in ligand–protein interactions confirmed the high stability of the resulting complexes. When compared to known standard drugs, the studied molecule displayed a remarkable antimalarial activity, as indicated by higher binding affinity (B.E. −5.86 kcal/mol & Ki = 50.23 M). The pre-selected molecule could be presented as a promising drug candidate for the development of novel antimicrobial agents. Full article
(This article belongs to the Special Issue Density Functional Theory in The Age of Chemical Intelligence)
Recent Advances in Visible-Light Photoredox Catalysis for the Thiol-Ene/Yne Reactions
Qian Xiao
Qing-Xiao Tong
Jian-Ji Zhong
Visible-light photoredox catalysis has been established as a popular and powerful tool for organic transformations owing to its inherent characterization of environmental friendliness and sustainability in the past decades. The thiol-ene/yne reactions, the direct hydrothiolation of alkenes/alkynes with thiols, represents one of the [...] Read more.
Visible-light photoredox catalysis has been established as a popular and powerful tool for organic transformations owing to its inherent characterization of environmental friendliness and sustainability in the past decades. The thiol-ene/yne reactions, the direct hydrothiolation of alkenes/alkynes with thiols, represents one of the most efficient and atom-economic approaches for the carbon-sulfur bonds construction. In traditional methodologies, harsh conditions such as stoichiometric reagents or a specialized UV photo-apparatus were necessary suffering from various disadvantages. In particular, visible-light photoredox catalysis has also been demonstrated to be a greener and milder protocol for the thiol-ene/yne reactions in recent years. Additionally, unprecedented advancements have been achieved in this area during the past decade. In this review, we will summarize the recent advances in visible-light photoredox catalyzed thiol-ene/yne reactions from 2015 to 2021. Synthetic strategies, substrate scope, and proposed reaction pathways are mainly discussed. Full article
(This article belongs to the Special Issue Photoredox Catalysis for Sustainable Chemical Synthesis/Medicinal Chemistry)
Analytical Evaluation of Carbamate and Organophosphate Pesticides in Human and Environmental Matrices: A Review
Nonkululeko Landy Mdeni
Abiodun Olagoke Adeniji
Anthony Ifeanyi Okoh
Omobola Oluranti Okoh
Pesticides are synthetic compounds that may become environmental contaminants through their use and application. The high productivity achieved in the agricultural industry can be credited to the use and application of pesticides by way of pest and insect control. As much as pesticides [...] Read more.
Pesticides are synthetic compounds that may become environmental contaminants through their use and application. The high productivity achieved in the agricultural industry can be credited to the use and application of pesticides by way of pest and insect control. As much as pesticides have a positive impact on the agricultural industry, some disadvantages come with their application in the environment because they are intentionally toxic, and this is more towards non-target organisms. They are grouped into chlorophenols, organochlorines, synthetic pyrethroid, carbamates, and organophosphorus based on their structure. The symptoms of exposure to carbamate (CM) and organophosphates (OP) are similar, although poisoning from CM is of a shorter duration. The analytical evaluation of carbamate and organophosphate pesticides in human and environmental matrices are reviewed using suitable extraction and analytical methods. Full article
(This article belongs to the Special Issue Frontiers in Analytical Methods for Water Analysis)
Development of Optogenetic Dual-Switch System for Rewiring Metabolic Flux for Polyhydroxybutyrate Production
Sumeng Wang
Yue Luo
Wei Jiang
Xiaomeng Li
Qingsheng Qi
Quanfeng Liang
Several strategies, including inducer addition and biosensor use, have been developed for dynamical regulation. However, the toxicity, cost, and inflexibility of existing strategies have created a demand for superior technology. In this study, we designed an optogenetic dual-switch system and applied it to [...] Read more.
Several strategies, including inducer addition and biosensor use, have been developed for dynamical regulation. However, the toxicity, cost, and inflexibility of existing strategies have created a demand for superior technology. In this study, we designed an optogenetic dual-switch system and applied it to increase polyhydroxybutyrate (PHB) production. First, an optimized chromatic acclimation sensor/regulator (RBS10–CcaS#10–CcaR) system (comprising an optimized ribosomal binding site (RBS), light sensory protein CcaS, and response regulator CcaR) was selected for a wide sensing range of approximately 10-fold between green-light activation and red-light repression. The RBS10–CcaS#10–CcaR system was combined with a blue light-activated YF1–FixJ–PhlF system (containing histidine kinase YF1, response regulator FixJ, and repressor PhlF) engineered with reduced crosstalk. Finally, the optogenetic dual-switch system was used to rewire the metabolic flux for PHB production by regulating the sequences and intervals of the citrate synthase gene (gltA) and PHB synthesis gene (phbCAB) expression. Consequently, the strain RBS34, which has high gltA expression and a time lag of 3 h, achieved the highest PHB content of 16.6 wt%, which was approximately 3-fold that of F34 (expressed at 0 h). The results indicate that the optogenetic dual-switch system was verified as a practical and convenient tool for increasing PHB production. Full article
(This article belongs to the Special Issue Microbial Synthesis of Polymers and Polymer Precursors)
Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies
Alessia Catalano
Domenico Iacopetta
Jessica Ceramella
Domenica Scumaci
Federica Giuzio
Carmela Saturnino
Stefano Aquaro
Camillo Rosano
Maria Stefania Sinicropi
Multidrug resistance is a leading concern in public health. It describes a complex phenotype whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic compounds, many of which are anticancer agents. Multidrug resistance may be also related to antimicrobial drugs, [...] Read more.
Multidrug resistance is a leading concern in public health. It describes a complex phenotype whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic compounds, many of which are anticancer agents. Multidrug resistance may be also related to antimicrobial drugs, and is known to be one of the most serious global public health threats of this century. Indeed, this phenomenon has increased both mortality and morbidity as a consequence of treatment failures and its incidence in healthcare costs. The large amounts of antibiotics used in human therapies, as well as for farm animals and even for fishes in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple drugs. It is not negligible that the ongoing COVID-19 pandemic may further contribute to antimicrobial resistance. In this paper, multidrug resistance and antimicrobial resistance are underlined, focusing on the therapeutic options to overcome these obstacles in drug treatments. Lastly, some recent studies on nanodrug delivery systems have been reviewed since they may represent a significant approach for overcoming resistance. Full article
(This article belongs to the Section Medicinal Chemistry)
Colorimetric and Electrochemical Methods for the Detection of SARS-CoV-2 Main Protease by Peptide-Triggered Assembly of Gold Nanoparticles
Yunxiao Feng
Gang Liu
Ming La
Lin Liu
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) has been regarded as one of the ideal targets for the development of antiviral drugs. The currently used methods for the probing of Mpro activity and the screening of its inhibitors require the [...] Read more.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) has been regarded as one of the ideal targets for the development of antiviral drugs. The currently used methods for the probing of Mpro activity and the screening of its inhibitors require the use of a double-labeled peptide substrate. In this work, we suggested that the label-free peptide substrate could induce the aggregation of AuNPs through the electrostatic interactions, and the cleavage of the peptide by the Mpro inhibited the aggregation of AuNPs. This fact allowed for the visual analysis of Mpro activity by observing the color change of the AuNPs suspension. Furthermore, the co-assembly of AuNPs and peptide was achieved on the peptide-covered electrode surface. Cleavage of the peptide substrate by the Mpro limited the formation of AuNPs/peptide assembles, thus allowing for the development of a simple and sensitive electrochemical method for Mpro detection in serum samples. The change of the electrochemical signal was easily monitored by electrochemical impedance spectroscopy (EIS). The detection limits of the colorimetric and electrochemical methods are 10 and 0.1 pM, respectively. This work should be valuable for the development of effective antiviral drugs and the design of novel optical and electrical biosensors. Full article
(This article belongs to the Special Issue Functional Nanomaterials in Biomedicine)
Supplementary File 1 (ZIP, 2580 KiB)
Preparation of Deuterium Labeled Compounds by Pd/C-Al-D2O Facilitated Selective H-D Exchange Reactions
Anne Kokel
Dora Kadish
Béla Török
The chemo/regioselective H-D exchange of amino acids and synthetic building blocks by an environmentally benign Pd/C-Al-D2O catalytic system is described. Due to the importance of isotope labeled compounds in medicinal chemistry and structural biology, notably their use as improved drug candidates [...] Read more.
The chemo/regioselective H-D exchange of amino acids and synthetic building blocks by an environmentally benign Pd/C-Al-D2O catalytic system is described. Due to the importance of isotope labeled compounds in medicinal chemistry and structural biology, notably their use as improved drug candidates and biological probes, the efficient and selective deuteration methods are of great interest. The approach is based on selective H-D exchange reactions where the deuterium source is simple D2O. D2 gas is generated in situ from the reaction of aluminum and D2O, while the commercially available palladium catalyst assists the H-D exchange reaction. The high selectivity and efficiency, as well as the simplicity and safe nature of the procedure make this method an environmentally benign alternative to current alternatives. Full article
(This article belongs to the Special Issue Organic Chemistry in the USA)
Thyroid-Stimulating Hormone Favors Runx2-Mediated Matrix Mineralization in HOS and SaOS2 Cells: An In Vitro and In Silico Approach
Ramajayam Govindan
Mohamed El-Sherbiny
Khalid Mohamed Morsy Ibraheem
Srinivasan Narasimhan
Mohamed EL-Dosoky Mohamed Salama
Fazil Ahmad
Selvaraj Jayaraman
Vishnu Priya Veeraraghavan
Srinivasan Vengadassalapathy
Surapaneni Krishna Mohan
Vidhya Rekha Umapathy
Gayathri Rengasamy
Shazia Fathima Jaffer Hussain
Maheshkumar Poomarimuthu
Senthilkumar Kalimuthu
Osteoporosis is a skeletal disease that is both systemic and silent characterized by an unbalanced activity of bone remodeling leading to bone loss. Rising evidences demonstrate that thyroid stimulating hormone (TSH) has an important role in the regulation on the metabolism of bone. [...] Read more.
Osteoporosis is a skeletal disease that is both systemic and silent characterized by an unbalanced activity of bone remodeling leading to bone loss. Rising evidences demonstrate that thyroid stimulating hormone (TSH) has an important role in the regulation on the metabolism of bone. However, TSH regulation on human osteoblast essential transcriptional factors has not been identified. Current study examined the role of TSH on human osteoblastic Runx2 expression and their functional genes by in vitro and in slico analysis. Human osteoblast like (HOS and SaoS-2) cells were cultured with DMEM and treated with hTSH at the concentration of 0.01 ng/mL and 10 ng/mL. After treatment, osteoblastic Runx2 and IGF-1R beta expression were studied using RT-PCR and western blot analysis. TSH treatment induced osteoblastic essential transcriptional factor, Runx2 in HOS and SaOS2 cells on 48 h duration and elevated the expression of IGF-IR β gene and Protein in SaoS-2 cells. TSH also promotes Runx2 responsive genes such as ALP, Collagen and osteocalcin in SaOS2 cells on day 2 to day 14 of 10 ng/mL of treatment and favors' matrix mineralization matrix in these cells. In addition, TSH facilitated human osteoblastic cells to mineralize their matrix confirmed by day 21 of alizarin red calcium staining. In silico study was performed to check CREB and ELK1 interaction with Runx2. Results of in silico analysis showed that TSH mediated signalling molecules such as CREB and ELK1 showed interaction with Runx2 which involve in osteobalstic gene expression and differentiation. Present findings confirm that TSH promotes Runx2 expression, osteoblastic responsive genes and bone matrix formation. Full article
(This article belongs to the Special Issue Bioactive Molecules for Biodegradation and Antimicrobials)
Effect of Extraction Procedures with Ultrasound and Cellulolytic Enzymes on the Structural and Functional Properties of Citrus grandis Osbeck Seed Mucilage
Yu-Cheng Yeh
Lih-Shiuh Lai
The structural and functional properties of Citrus grandis Osbeck (CGO) seed mucilage by different extraction practices, including conventional citrate buffer, ultrasonic-assisted (UAE), enzymatic-assisted extraction (EAE) with cellulase or Celluclast󠅔® 1.5 L and various ultrasonic-assisted enzymatic extraction (UAEE) procedures were investigated. It was [...] Read more.
The structural and functional properties of Citrus grandis Osbeck (CGO) seed mucilage by different extraction practices, including conventional citrate buffer, ultrasonic-assisted (UAE), enzymatic-assisted extraction (EAE) with cellulase or Celluclast󠅔® 1.5 L and various ultrasonic-assisted enzymatic extraction (UAEE) procedures were investigated. It was found that CGO seed from agricultural and processing byproducts is an excellent new source of high methoxyl pectin with quite high intrinsic viscosity (about 108.64 dL/g) and molecular weight (about 1.9 × 106) as compared with other pectin sources. UAEE with Celluclast󠅔® 1.5 L enhanced the extraction yield most pronouncedly (about 2.3 times). Moreover, the monosaccharide composition of CGO seed mucilage is least affected by EAE with Celluclast󠅔® 1.5 L. In contrast, EAE with cellulase dramatically reduces the galacturonic acid (GalA) content to less than 60 molar%, and increases the glucose (Glc) content pronouncedly (to about 40 molar%), which may be considered as an adverse effect in terms of pectin purity. Though extraction procedures involved with ultrasound and cellulolytic enzymes generally show a decrease in GalA contents, weight average molar mass and intrinsic viscosity, EAE with Celluclast󠅔® 1.5 L is least affected, followed by UAE and UAEE with Celluclast󠅔® 1.5 L. These features can be leveraged in favor of diversified applications. Full article
(This article belongs to the Special Issue Molecular Characteristics and Functional Properties in Agri-Food)
Prion Strains Differ in Susceptibility to Photodynamic Oxidation
Marie Kostelanska
Karel Holada
Prion disorders, or transmissible spongiform encephalophaties (TSE), are fatal neurodegenerative diseases affecting mammals. Prion-infectious particles comprise of misfolded pathological prion proteins (PrPTSE). Different TSEs are associated with distinct PrPTSE folds called prion strains. The high resistance of prions to conventional [...] Read more.
Prion disorders, or transmissible spongiform encephalophaties (TSE), are fatal neurodegenerative diseases affecting mammals. Prion-infectious particles comprise of misfolded pathological prion proteins (PrPTSE). Different TSEs are associated with distinct PrPTSE folds called prion strains. The high resistance of prions to conventional sterilization increases the risk of prion transmission in medical, veterinary and food industry practices. Recently, we have demonstrated the ability of disulfonated hydroxyaluminum phthalocyanine to photodynamically inactivate mouse RML prions by generated singlet oxygen. Herein, we studied the efficiency of three phthalocyanine derivatives in photodynamic treatment of seven mouse adapted prion strains originating from sheep, human, and cow species. We report the different susceptibilities of the strains to photodynamic oxidative elimination of PrPTSE epitopes: RML, A139, Fu-1 > mBSE, mvCJD > ME7, 22L. The efficiency of the phthalocyanine derivatives in the epitope elimination also differed (AlPcOH(SO3)2 > ZnPc(SO3)1–3 > SiPc(OH)2(SO3)1–3) and was not correlated to the yields of generated singlet oxygen. Our data suggest that the structural properties of both the phthalocyanine and the PrPTSE strain may affect the effectiveness of the photodynamic prion inactivation. Our finding provides a new option for the discrimination of prion strains and highlights the necessity of utilizing range of prion strains when validating the photodynamic prion decontamination procedures. Full article
(This article belongs to the Special Issue Proteomics and Protein Biochemistry in Diseases)
Polyphenolic Composition and Antioxidant Activity (ORAC, EPR and Cellular) of Different Extracts of Argylia radiata Vitroplants and Natural Roots
Ady Giordano
Pablo Morales-Tapia
Mauricio Moncada-Basualto
Josué Pozo-Martínez
Claudio Olea-Azar
Aleksandra Nesic
Gustavo Cabrera-Barjas
Plant biochemistry studies have increased in recent years due to their potential to improve human health. Argylia radiata is an extremophile plant with an interesting polyphenolic profile. However, its biomass is scarce and occasionally available. Argylia in vitro biomass was obtained from tissue [...] Read more.
Plant biochemistry studies have increased in recent years due to their potential to improve human health. Argylia radiata is an extremophile plant with an interesting polyphenolic profile. However, its biomass is scarce and occasionally available. Argylia in vitro biomass was obtained from tissue culture and compared with in vivo roots regarding its polyphenolic and flavonoid content. Different solvents were used to prepare extracts from the in vitro tissue of callus and aerial plant organs and in vivo roots. UPLC-MS/MS was used to assess the chemical composition of each extract. ORAC-FL and scavenging of free radicals (DPPH and OH) methods were used to determine the antioxidant capacity of extracts. Furthermore, the biological activity of the extracts was established using the cellular antioxidant activity method. The vitroplants were a good source of polyphenols (25–68 mg GAE/100 g tissue FW), and methanol was the most efficient solvent. Eight polyphenolic compounds were identified, and their antioxidant properties were investigated by different chemical methods with EPR demonstrating its specific scavenging activity against free radicals. All extracts showed cellular dose-dependent antioxidant activity. The methanolic extract of vitroplants showed the highest cellular antioxidant activity (44.6% and 51%) at 1 and 10 µg/mL of extract, respectively. Vitroplants of A. radiata are proposed as a biotechnological product as a source of antioxidant compounds with multiple applications. Full article
Open AccessSystematic Review
Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation
Catarina Gonçalves
Daniela Fernandes
Inês Silva
Vanessa Mateus
This systematic review aimed to evaluate the potential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammation. A search was conducted in the databases PubMed, Scopus, and Web of Science, with related keywords. The inclusion criteria were inflammation, plant, and [...] Read more.
This systematic review aimed to evaluate the potential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammation. A search was conducted in the databases PubMed, Scopus, and Web of Science, with related keywords. The inclusion criteria were inflammation, plant, and studies on rats or mice; while, the exclusion criteria were reviews, studies with in vitro models, and associated plants. The predominant animal models were paw edema, acute liver injury, and asthma. Rosemary was more commonly used in its entirety than in compounds, and the prevalent methods of extraction were maceration and hydrodistillation. The most common routes of administration reported were gavage, intraperitoneal, and oral, on a route-dependent dosage. Treatment took place daily, or was single-dose, on average for 21 days, and it more often started before the induction. The most evaluated biomarkers were tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, myeloperoxidase (MPO), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), malondialdehyde (MDA), and superoxide dismutase (SOD). The best results emerged at a dose of 60 mg/kg, via IP of carnosic acid, a dose of 400 mg/kg via gavage of Rosmarinus officinalis, and a dose of 10 mg/kg via IP of rosmarinic acid. Rosmarinus officinalis L. showed anti-inflammatory activity before and after induction of treatments. Full article
(This article belongs to the Special Issue Medicinal Plants and Industrial Crops: Phytochemistry and Metabolic Diseases)
Bone Dimensional Change Following Immediate Implant Placement in Posterior Teeth with CBCT: A 6-Month Prospective Clinical Study
Witchayani Bungthong
Parinya Amornsettachai
Penporn Luangchana
Boontharika Chuenjitkuntaworn
Suphachai Suphangul
This prospective clinical study aimed to evaluate the peri-implant hard tissue dimensional change at 6 months of immediate implant placement with bone graft materials in the posterior area using cone-beam computed tomography (CBCT). Twelve dental implants were placed concurrently following tooth extraction in [...] Read more.
This prospective clinical study aimed to evaluate the peri-implant hard tissue dimensional change at 6 months of immediate implant placement with bone graft materials in the posterior area using cone-beam computed tomography (CBCT). Twelve dental implants were placed concurrently following tooth extraction in the posterior area and filled with xenograft particles. The CBCT images were taken immediately after surgical procedures and then at 6 months follow-up. To evaluate the hard tissue changes, the vertical and horizontal bone thickness were analyzed and measured using ImageJ software. Paired t-test or Wilcoxon match-pair signed-rank test was done to analyze the changes of hard tissue values at the same level between immediately and 6 months following immediate implant placement. Independent t-test or Mann–Whitney U test was used to analyze the dimensional change in the vertical and horizontal direction in buccal and lingual aspects. The level of significance was set at p value = 0.05. All implants were successfully osseointegrated. At 6 months follow-up, the vertical bone change at the buccal aspect was −0.69 mm and at the lingual aspect −0.39 mm. For horizontal bone thickness, the bone dimensional changes at 0, 1, 5, and 9 mm levels from the implant platform were −0.62 mm, −0.70 mm, −0.24 mm, and −0.22 mm, respectively. A significant bone reduction was observed in all measurement levels during the 6 months after implant placement (p value < 0.05). It was noted that even with bone grafting, a decrease in bone thickness was seen following the immediate implant placement. Therefore, this technique can be an alternative method to place the implant in the posterior area. Full article
(This article belongs to the Special Issue Advancements of Materials for Prosthodontics and Dental Implantology)
The Anti-Adiposity Mechanisms of Ampelopsin and Vine Tea Extract in High Fat Diet and Alcohol-Induced Fatty Liver Mouse Models
Jianbo Wu
Kenchi Miyasaka
Wakana Yamada
Shogo Takeda
Norihito Shimizu
Hiroshi Shimoda
Ampelopsis grossedentata (AG) is an ancient medicinal plant that is mainly distributed and used in southwest China. It exerts therapeutic effects, such as antioxidant, anti-diabetic, and anti-inflammatory activities, reductions in blood pressure and cholesterol and hepatoprotective effects. Researchers in China recently reported the [...] Read more.
Ampelopsis grossedentata (AG) is an ancient medicinal plant that is mainly distributed and used in southwest China. It exerts therapeutic effects, such as antioxidant, anti-diabetic, and anti-inflammatory activities, reductions in blood pressure and cholesterol and hepatoprotective effects. Researchers in China recently reported the anti-obesity effects of AG extract in diet-induced obese mice and rats. To verify these findings, we herein investigated the effects of AG extract and its principal compound, ampelopsin, in high-fat diet (HFD)- and alcohol diet-fed mice, olive oil-loaded mice, and differentiated 3T3-L1 cells. The results obtained showed that AG extract and ampelopsin significantly suppressed increases in the weights of body, livers and abdominal fat and also up-regulated the expression of carnitine palmitoyltransferase 1A in HFD-fed mice. In olive oil-loaded mice, AG extract and ampelopsin significantly attenuated increases in serum triglyceride (TG) levels. In differentiated 3T3-L1 cells, AG extract and ampelopsin promoted TG decomposition, which appeared to be attributed to the expression of hormone-sensitive lipase. In alcohol diet-fed mice, AG extract and ampelopsin reduced serum levels of ethanol, glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) and liver TG. An examination of metabolic enzyme expression patterns revealed that AG extract and ampelopsin mainly enhanced the expression of aldehyde dehydrogenase and suppressed that of cytochrome P450, family 2, subfamily e1. In conclusion, AG extract and ampelopsin suppressed diet-induced intestinal fat accumulation and reduced the risk of fatty liver associated with HFD and alcohol consumption. Full article
(This article belongs to the Topic Applied Sciences in Functional Foods)
Transformation of Thia[7]helicene to Aza[7]helicenes and [7]Helicene-like Compounds via Aromatic Metamorphosis
Keisuke Uematsu
Chikara Hayasaka
Ko Takase
Keiichi Noguchi
Koji Nakano
[n]Helicenes with helically twisted structures have attracted increasing interest owing to their unique properties. Therefore, it has been an important issue to develop facile synthetic methodologies which allow access to a variety of [n]helicenes. Here we report the synthesis [...] Read more.
[n]Helicenes with helically twisted structures have attracted increasing interest owing to their unique properties. Therefore, it has been an important issue to develop facile synthetic methodologies which allow access to a variety of [n]helicenes. Here we report the synthesis of [7]helicenes and [7]helicene-like compounds from the thia[7]helicene as a common starting material. Desulfurative dilithiation of the thia[7]helicene and the subsequent reaction with silicon and phosphorus electrophiles afforded the silole- and phosphole-fused [7]helicene-like compounds, respectively. The cyclopentadiene-fused [7]helicene-like compound and the pyrrole-fused aza[7]helicenes were also successfully synthesized via twofold SNAr reactions of the thia[7]helicene S,S-dioxide with the carbon and nitrogen nucleophiles, respectively. The thia[7]helicene S,S-dioxide showed a slightly red-shifted absorption spectrum than the parent thia[7]helicene, which was well demonstrated by the theoretical calculations. The substituents on the silicon atom of silole-fused [7]helicene-like compounds have little impact on the longest absorption maximum. Such little effect of the substituents on absorption properties was also observed for cyclopentadiene-fused [7]helicene-like compounds and aza[7]helicenes and was well demonstrated by the theoretical calculations. The thia[7]helicene S,S-dioxide and the silole-fused [7]helicene-like compound exhibited bright blue emission, and the cyclopentadiene-fused [7]helicene-like compound and the aza[7]helicenes showed strong violet emission. Each single enantiomer of the aza[7]helicenes showed circularly-polarized luminescence with the dissymmetry factors of 4.2⁓4.4 × 10−3. Full article
(This article belongs to the Special Issue Polycyclic(hetero)aromatic Compounds)
Cationic Emulsion Polymerization of Octamethylcyclotetrasiloxane (D4) in Mixtures with Alkoxysilanes
Janusz Kozakiewicz
Joanna Trzaskowska
Michał Kędzierski
Joanna Sołtysiak
Elżbieta U. Stolarczyk
Izabela Ofat-Kawalec
Jarosław Przybylski
The cationic emulsion polymerization of octamethylcyclotetrasiloxane (D4) in mixtures with methyltriethoxysilane (MTES) and vinyltriethoxysilane (VTES) was studied by FTIR ATR, GC, the development of a toluene insoluble fraction of the polymer and a gravimetric analysis. The polymerization of D4 alone was also conducted [...] Read more.
The cationic emulsion polymerization of octamethylcyclotetrasiloxane (D4) in mixtures with methyltriethoxysilane (MTES) and vinyltriethoxysilane (VTES) was studied by FTIR ATR, GC, the development of a toluene insoluble fraction of the polymer and a gravimetric analysis. The polymerization of D4 alone was also conducted for comparison and, additionally, the development of molecular weight of polydimethylsiloxane (PDMS) obtained in that process was studied by GPC. Dodecylbenzenesulphonic acid (DBSA) was used as a surfactant and catalyst. The process was carried out in a "starved feed" mode by adding dropwise the monomer mixture to the aqueous solution of DBSA. FTIR ATR spectra were recorded by the sensor placed in the probe tip of a ReactIR 15TM apparatus. It was found that the silicone polymer formation proceeded faster when D4 was polymerized in the mixture with alkoxysilanes, especially in the beginning of the process, and that already at the beginning of the process, the partly crosslinked polymer was formed. The induction period of ca. 30 min was observed and the concentration of cyclic siloxanes (D4 and decamethylcyclopentasiloxane—D5) remained at a very low level in the course of the reaction and only traces were detected in the final product. The particle size development in the course of the reaction was also studied and it was found that the particle size distribution was bimodal and was broadening as the reaction proceeded, though this phenomenon was less distinct when D4 was polymerized in the mixtures with alkoxysilanes. The structure of the reaction product was confirmed by 29Si NMR. Full article
(This article belongs to the Special Issue Various Aspects of Silicon Polymer Chemistry: A Themed Issue in Honor of Professor Julian Chojnowski on the Occasion of His 85th Birthday)
A Comprehensive Review on the Techniques for Extraction of Bioactive Compounds from Medicinal Cannabis
Hebah Muhsien Sabiah AL Ubeed
Deep Jyoti Bhuyan
Muhammad A. Alsherbiny
Amrita Basu
Quan V. Vuong
Cannabis is well-known for its numerous therapeutic activities, as demonstrated in pre-clinical and clinical studies primarily due to its bioactive compounds. The Cannabis industry is rapidly growing; therefore, product development and extraction methods have become crucial aspects of Cannabis research. The evaluation of [...] Read more.
Cannabis is well-known for its numerous therapeutic activities, as demonstrated in pre-clinical and clinical studies primarily due to its bioactive compounds. The Cannabis industry is rapidly growing; therefore, product development and extraction methods have become crucial aspects of Cannabis research. The evaluation of the current extraction methods implemented in the Cannabis industry and scientific literature to produce consistent, reliable, and potent medicinal Cannabis extracts is prudent. Furthermore, these processes must be subjected to higher levels of scientific stringency, as Cannabis has been increasingly used for various ailments, and the Cannabis industry is receiving acceptance in different countries. We comprehensively analysed the current literature and drew a critical summary of the extraction methods implemented thus far to recover bioactive compounds from medicinal Cannabis. Moreover, this review outlines the major bioactive compounds in Cannabis, discusses critical factors affecting extraction yields, and proposes future considerations for the effective extraction of bioactive compounds from Cannabis. Overall, research on medicinal marijuana is limited, with most reports on the industrial hemp variety of Cannabis or pure isolates. We also propose the development of sustainable Cannabis extraction methods through the implementation of mathematical prediction models in future studies. Full article
(This article belongs to the Special Issue High Times for Cannabinoid Research)
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First US order for EC145 Mercedes-Benz Style
30-Oct-2012 Source: American Eurocopter
American Eurocopter today announced Speedway Aviation in New Hampshire has placed the first U.S. based order for the new EC145 Mercedes-Benz Style helicopter, featuring an exclusive, special edition package like nothing seen before in the helicopter industry.
The aircraft is the result of a collaborative effort between Eurocopter, the world's leading producer of corporate and VIP helicopters, and Mercedes Benz, the automotive group that sets global standards for luxury and style. This will be the third special edition EC145 Mercedes-Benz Style to be produced since its introduction in late 2010 and the first to be operated in the United States.
JBI Helicopters of New Hampshire will be managing the newest EC145 Mercedes Benz-Style helicopter for Speedway Aviation once it is delivered to its New England based owners in 2013. The client's decision to purchase the EC145 was made after an exhaustive review of each of the twin-engine helicopters on the market.
"The Eurocopter product was selected because of its safety record, reliability, and supportability," said Kurt West, vice president of JBI Helicopter Service. "The Mercedes-Benz Style package was the perfect complement to an already impressive product and the client sees the value in having the leaders in automotive interior design working with the helicopter experts."
"It's the perfect marriage of the safest, most reliable, helicopter in its class and a stylish finish created by Mercedes-Benz," says American Eurocopter's Vice President of Commercial Sales and Marketing, Treg Manning. "We are confident that our clients here in the U.S. will be impressed when they see this special edition EC145 and expect there will be an increasing demand for the aircraft, particularly since the package will also be available on the next generation EC145T2. Once that aircraft enters full production, we are sure to see the relationship with Mercedes-Benz continue for years to come."
Created by the Mercedes-Benz Advanced Design Division based in Como, Italy, the package is the most comprehensive available, featuring exquisite leather and wood appointments, an advanced in-flight entertainment system, ambient lighting, modular storage cabinets that can be easily reconfigured, and the choice of up to eight-place seating. The design team has also modified the external look of the EC145 to give it a distinguished appearance including a redesign of the front end, special shrouding for the skid gear, and a custom paint scheme.
The twin-engine EC145 has proven its worth in many roles, making it the obvious platform of choice for this exclusive package. It offers not only a very large and comfortable cabin area but also two rear doors that make it extremely easy to load luggage, sporting equipment or the spoils from shopping trips. With skid gear, the aircraft has greater flexibility for landing, including unprepared surfaces such as an open field near the hunting lodge or a grassy knoll at the golf course. With the EC145's advanced auto-pilot system and avionics, the pilots can spend more time focusing on the environment outside of the aircraft thereby providing more safety for the passengers.
The search to find the best product led Mr. West to a number of locations on behalf of his client, including Donauwörth, Germany, where the Eurocopter production line for the commercial version of the EC145 is located; Stuttgart, Germany, for a look behind the curtain at the Mercedes-Benz headquarters; Como, Italy, to meet with the design team; and finally Grand Prairie, Texas, to visit the training academy and customer support management at American Eurocopter's headquarters.
"Being able to witness firsthand the vast infrastructure and people standing behind this product was very important," said West. "Our client demands only the best and we believe American Eurocopter will deliver just that."
About American Eurocopter
American Eurocopter is the U.S. affiliate of Eurocopter, the largest helicopter manufacturer in the world, and a subsidiary of EADS North America Holdings, the North American operations of EADS, the second largest aerospace and defense company in the world. American Eurocopter is a helicopter manufacturer and markets, sells and supports the broadest range of civil and parapublic helicopters offered by any manufacturer. The product line represents the most cost-effective, technologically-advanced helicopters, ranging from light single to heavy twin, serving all markets and missions. Company headquarters and main facility are in Grand Prairie, TX, with a large manufacturing and production facility in Columbus, MS.
American Eurocopter, Civil, EC145, Eurocopter, JBI Helicopters, NBAA 2012, News, Speedway Aviation, US-New Hampshire
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Gama Aviation starts Scottish EMS operations after taking contract back from Babcock | {
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3 More Genres of Romantic Movies To Be Released by Star Cinema this Last Quarter of 2012!
byRocky Chua - Friday, October 19, 2012
Star Cinema is set to release three more films in the fourth quarter of 2012 including this year's biggest comedy movie "This Guy's In Love With You Mare," first Filipino-Thai film "Suddenly It's Magic," and Star Magic's 20th anniversary movie "24/7 in Love."
"This Guy's In Love With You, Mare," the wild comedy riot directed by Wenn Deramas and topbilled by the box-office comedy trio of Toni Gonzaga, Luis Manzano and Vice Ganda continues to spread fun to moviegoers on its second blockbuster week.
Star Cinema's first Filipino-Thai film, "Suddenly It's Magic" is the highly anticipated romantic-comedy flick starred by Erich Gonzales and Thai superstar Mario Maurer. Directed by Rory Quintos, the movie is set to be released on October 31.
Meanwhile, the romance anthology "24/7 in Love" will be starred by some of the biggest Star Magic talents including Piolo Pascual, John Lloyd Cruz, Bea Alonzo, Gerald Anderson, Kim Chiu, Maja Salvador, Sam Milby, Diether Ocampo, Angelica Panganiban, Zaijan Jaranilla, Xyriel Manabat, and Pokwang. The Star Magic 20th anniversary film, which is set to be screened nationwide in November, is directed by John D. Lazatin, Mae Czarina Cruz, Frasco Santos Mortiz, and Dado Lumibao.(www.tvseriescraze.blogspot.com)
Tags 2012 movie ABS-CBN Films Movie Feature Star Cinema Star Magic Suddenly Its Magic
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Pop/Bollywood Music
I'd like to kiss Adele: Rick Ross
I'd like to kiss Adele: Rick Ross
Hip-hop superstar Rick Ross admits he is in love with Adele's new album 25 and he'd like to kiss her.
By: PTI
Los Angeles | January 20, 2016 12:31 IST
Rick Ross admits he is in love with Adele's new album 25 and he'd like to kiss her.
Hip-hop superstar Rick Ross admits he is in love with Adele's new album 25 and he'd like to kiss her.
"I love Adele. When I see her, I may kiss Adele.
"She speaks for so many people. When I hear her voice, I stop and make that face and say, 'What is this man?' I just gaze off into the sky for a second and think creatively," he said.
And Ross, 39, is keen to hit the studio with the "Hello" singer, adding, "I've got a beat ready for her if I ever run across her."
Adele recently proved her love of hip-hop after joining British comedian and TV host James Corden for a 'carpool karaoke' sketch on his US talk show, during which she rapped along to Nicki Minaj's verse on Kanye West's 2010 hit "Monster", which also featured Ross and Jay Z.
Leonardo DiCaprio deserves an Oscar win: Kate Winslet
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20 best photos from Athiya Shetty-KL Rahul's wedding | {
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Q: Laravel 6 - My Route doesnt work in Resource Controller I have a Admincontroller. Here I can do a simple CRUD function.
With this route: Route::resource('admin', 'AdminController');
Everything (create, edit destroy) works perfect.
Now I have a new function in this Controller.
Named deactivate. Here i can deactivate users.
this is the function:
public function deactivate($id)
{
$user = User::find($id);
if ($user->verified == 1){
$user->verified = 0;
$user->save();
$angebot = Angebot::where('firma', $id);
$angebot->delete();
return redirect('/admin')->with('success', 'Nutzer wurde erfolgreich deaktiviert');
}
if($user->verified == 0){
$user->verified = 1;
$user->save();
return redirect('/admin')->with('success', 'Nutzer wurde erfolgreich aktiviert');
}
}
for this function i have this route:
Route::get('admin/{id}', 'AdminController@deactivate')->name('admin.deactivate');
in my view it looks like this:
<a href="{{ route('admin.deactivate',$user->id)}}">
if i click on this link it goes to /admin/2 (so it gives me the right id)
but it doesnt redirekt to /admin so i think the route doesnt work because the function should work
does anyone know why?
is it because i do this in my ressource controller?
A: When you want to add an extra route to your resource route,add it above the resource route..
Route::get('admin/{id}', 'AdminController@deactivate')->name('admin.deactivate');
Route::resource('admin', 'AdminController');
| {
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Adolph Ludvig Ribbing, later called Adolph de Leuven (10 January 1765 in Stockholm – 1 April 1843 in Paris), was a Swedish count and politician. He participated in the regicide of Gustav III of Sweden in 1792.
Life
Early life
Adolph Ribbing was the son of Count Fredrik Ribbing and Eva Helena Löwen. He spent his childhood at the Swedish royal court, as his mother was a popular socialite and the personal friend of both Louisa Ulrika of Prussia and Gustav III of Sweden. He received a military education in Berlin and Paris and became a member of the Life Guards.
Assassination of Gustav III
In the 1780s, Ribbing came in conflict with the monarch, Gustav III. His animosity was nurtured when Charlotta Eleonora De Geer, with whom he was in love, was matched by the king with count Hans Henrik von Essen. The engagement was widely disapproved of within the court because of sympathy with the popular Augusta von Fersen, to whom von Essen had been a long term lover, and Ribbing challenged von Essen to a duel. Ribbing injured von Essen in the duel, which took place in 1788. The duel caused a scandal and was regarded as a crime against the king. Ribbing was assigned to the garrison at Vaxholm Castle, which he regarded as an insult, and he therefore resigned from the army.
Ribbing took part in the of the Riksdag (the Swedish parliament), acting as one of the leaders of the opposition to the king's increasingly autocratic policies, such as the Union and Security Act.
In early 1792 he became involved in the plot to assassinate King Gustav, serving as the liaison between the conspiracy's leader Carl Fredrik Pechlin and the two men who had volunteered to carry out the murder, and Jacob Johan Anckarström in 1792. When Anckarström, Horn and Ribbing met on the afternoon of 16 March to finalise their plans, they did so at the house of Ribbing's lover, Louisa Hierta. That evening, the three conspirators attended a masquerade ball at the Royal Opera House, during which either Anckarström or Ribbing (who boasted of it later when in exile) shot and wounded the king.
Ribbing was arrested within a few days of the assassination and confessed to partaking in the conspiracy. Ribbing was sentenced to death in May 1792 and deprived of his rank as a noble, but the regent Duke Charles (later King Charles XIII) commuted the sentence to exile.
Exile
In August 1792 Ribbing was deported to Denmark, and thence made his way to France. Despite his enthusiasm for the Revolution he was unsettled by the burgeoning Reign of Terror and therefore left France, relocating first to Switzerland, where he had an affair with the famous writer Madame de Staël, and then back to Denmark. By 1796 the situation in France had calmed down sufficiently for Ribbing to return to Paris. He adopted his mother's maiden name, de Leuven, and lived a quiet, apolitical life for the next nineteen years, during which time he married Adèle Billard, daughter of the doctor Jean Pierre Billard.
As a known regicide, Adolph de Leuven (as he now called himself) did not feel safe during the White Terror of 1815, and he therefore left France again, this time for Brussels, where he found work as a journalist for the radical newspaper Le Vrai Libéral. His writings for this organ earned him the enmity of King Frederick William III of Prussia, who in 1820 persuaded the United Kingdom of the Netherlands to deport him. He returned to France, where persecution of radicals had eased since 1815, and continued to work in left-wing journalism, this time for Le Courrier Français. In 1830, aged 65, he took an active role in the July Revolution which overthrew the reactionary Bourbon restoration regime and installed the liberal July Monarchy. He died in 1843.
His son and namesake, Adolphe de Leuven, was a noted playwright and theatre director.
References
Sources
Cecilia af Klercker (1903). Hedvig Elisabeth Charlottas dagbok II 1783-1788. P.A. Norstedt & Söners förlag. Sid. 212
1765 births
Swedish duellists
1843 deaths
1792 crimes in Europe
Swedish regicides
Swedish people convicted of murder
People convicted of murder by Sweden
Swedish nobility
Swedish expatriates in France | {
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Child Tax Benefit Payment Dates 2023
The unfortunate reality of having children is that they're expensive. Some people aren't able to easily cover all of the cost that come from housing and caring for children.
These astronomical expenses cause financial strain and undue stress to thousands of people across the country, especially with the ever-rising and crippling effects of inflation driving prices of everyday items even higher.
Because of this, there have been many provincial and federal government programs established to provide parents with a bit of financial assistance. One of the most popular such programs is the Canada Child Benefit, or CCB. In this article we'll tell you everything you need to know about Child Tax Benefit payment dates.
What is the Canada Child Benefit (CCB)?
Before we delve into the complicated business of explaining child tax benefit payment dates, we first need to discuss what the Canada Child Benefit (CCB) is.
The Canada Child Bernefit is a benefit program exempt from taxes that's made available to parents who meet the eligibility requirements and have children under 18 years of age. The benefit program's goal is to ease some of the financial burden of parents facing poverty by providing them with financial aid offered by the government.
Here are some of the eligibility requirements for the Canada Childe Benefit (CCB):
You must be a primary caregiver
The child must be under 18 years of age
The child must live with you
The child must be a Canadian resident
Either you or your spouse has to be a Canadian citizen, protected person, permanent resident, a temporary resident living in Canada for at least 18 months or possesses a valid permit, or an Indigenous person (which is defined under the Indian Act).
How Much Money Can You Get Through the Canada Child Benefit (CCB)?
Another important thing we should discuss before jumping into the Child Tax Benefit payment dates is how much money you can get through the Canada Child Benefit.
In 2021, the tax year ran from July 2021- June 2022. The maximum amount of money you could receive for a child under 6 years old was $6,833, and the maximum amount you could receive for a child between 6 and 17 years of age was $5,765.
However, if you have joint custody of your child then you'll receive half of the amount you'd have received if you had full custody of the child.
Maximum CBB Benefits
Age Per Year Per Month
Under 6 years old $6,833 $569.41
6-17 years old $5,765 $480.41
The Canadian government calculates the amount of your monthly payment using your tax returns from the previous year. There's a CCB calculator on the Canadian government's website that you can use to get an estimated monthly payment calculation.
Some of the factors that affect the amount of your monthly payment are:
How many children you have
Your family's net combined total income
If you child is eligible for child disability benefits
Your residential status and if you qualify to receive provencial benefits
Your marital status
How Does Income Affect Your Canada Child Benefit (CCB) Amount?
If you're new to CCB payments and looking up Child Tax Benefit payment dates, then you'll probably need to know how your income can affect your Canada Child Benefit amount.
One of the major determining factors used to decide your Canada Child Benefit amount is your family's net combined income. For instance, if your family's net income is less than $32,028 then you qualify for the maximum benefit amount. That amount goes down if your income is higher than that, or if you have more children.
Here's how to calculate Canada Child Benefit (CCB) payment amounts:
Subtract the income threshold from your income to get your income over threshold amount.
Multiply the income over threshold amount by the reduction percentage.
To your reduction, add the fixed amount.
Subtract your reduction amount from the maximum benefit amount.
Canada Child Benefit (CCB) Payment Amounts According to Income Level and Number of Children
Number of Children Net Income of Family Over $32,028- $69,395 Net Income of Family over $69,395
1 7% of income over the threshold $2,616 + 3.2% of income over the threshold
2 13.5% of income over the threshold $5,044 + 5.7% of income over the threshold
3 19% of income over the threshold $7,100 + 8% of income over the threshold
4 or more 23% of income over the threshold $8,594 + 9.5% of income over the threshold
Extra Temporary Canada Child Benefit (CCB) Payments
One thing that may be useful to know if you're looking up information about Child Tax Benefit payment dates is the Extra Temporary Canada Child Benefit (CCB) payments.
These extra payments were issued because of the additional strain that COVID-19 put on parents. Studies indicate that 20,000 left the workforce while 68,000 men joined the workforce due to COVID-19. Of those over 20,000 women, at least 2/3 of them quit their jobs due to a lack of childcare.
Because of this, the Canadian government stepped in and offered additional assistance for families. Eligible applicants can receive somewhere between $600 and $1,200 in addition to their Canada Child Benefit.
You qualify for the maximum payment of $1,200 if your household income is less than $120,000 and you'll receive the payment in the form of quarterly installments of $300. You qualify for $600 if y9ur family's household income is more than $120,000, and you'll receive it in quarterly installments of $150.
The extra CCB payments for a family that makes less than $31,711 amounted to $7,965 for children under six, and $6,908 for kids 6-17 years of age. If you've come across this Child Tax Benefit Payment Dates article after 2020, then this bit of information likely isn't pertinent to you, save for historical or informative purposes.
Child Tax Benefit Payment Dates (CCB Dates)
If you're looking for child tax benefit payment dates, then you've come to the right place, because we're going to discuss them and lay them all out in this section.
The first thing you should know about child tax benefit payment dates is that their calendar year runs from June to July of the next year. If you sent in an application online, you can expect your first CCB payment within about 8 weeks, 11 if you applied by mail. The following is a list of child tax benefit dates:
Child Tax Benefit Payment Dates 2021:
As you can see, the majority of child tax benefit payment dates are between the 18th and 20th of the month, with the exception of December when payments are understandably issued a bit earlier before government agencies are closed for the holiday season.
Additionally, if your yearly CCB payments are under $240 then instead of receiving monthly payments on child tax benefit payment dates, you'll receive one payment for the year in July.
How to Apply for Canada Child Benefit
If you've yet to apply for the Canada Child Benefit or CCB, it's a good idea to learn more about the application process while you're learning about child tax benefit payment dates.
You have two different options when it comes to applying for the CCB.
The first option available to you is to apply for the CCB when your child is born. You can accomplish this by registering at the medical centre where your child was born, at the same time you're registering their birth documents.
Be sure that you sign the necessary section to provide consent to the Vital Statistics Agency to provide the Canada Revenue Agency (CRA) with the appropriate information. If you live in British Columbia, Ontario or Quebec, then you can do the registration online yourself.
CRA (Canada Revenue Agency) Application
If you didn't sign up for the CCB when your child was born (or didn't need to at the time), then you can sign up online using the CRA website. You'll need to make an account and then enter some information about your child, such as their date of birth, name and more.
If you choose to apply by mail instead, then you'll need to fill out the RC66 form, then send it to a tax center near you. Here are some other documents you may be required to send in along with your application:
Proof of Birth of the Child
You'll need to provide proof of birth for any child who hasn't received CCB from birth, was born outside of Canada, or is a year or more of age.
Letter from Female Parent
If you're a male parent who is primarily in charge of caring for the child and providing for them, then you may need a letter from the female parent to confirm this situation. However, if the child is primarily cared for by the female parent then a letter isn't typically required.
Miscellaneous Documents from the Past 11 Months
So long as your child was living with you 11 months ago, you'll have to present documentation to prove this, as well as your citizenship, your child's citizenship and documents to prove that you're the child's primary caregiver and have been for the past 11 months.
What are Child Tax Loans?
How to Cancel E-transfer
FAQs about the Child Tax Benefit Payment Dates
What were the 2018 child tax benefit payment dates?
This information isn't readily available online, unfortunately. We did extensively look. Considering the CBB has only existed since 2016, some of the past child tax benefit payment dates aren't listed online and have become difficult to find as a result. However, finding child tax benefit payment dates for the years 2020 and beyond are quite easy. This is likely due to a push for online listings during the height of the Covid-19 pandemic.
What are the 2022 child tax benefit payment dates?
The child tax benefit payment dates for 2022 are: January 20, 2022 February 18, 2022 March 18, 2022 April 20, 2022 May 20, 2022 June 20, 2022 July 20, 2022 August 19, 2022 September 20, 2022 October 20, 2022 November 18, 2022 December 13, 2022 The CRA website says that if you haven't received a payment on the child tax benefit payment dates to wait 5 days before notifying them.
The 2023 child tax benefit payment dates are: January 20, 2023 February 20, 2023 March 20, 2023 April 20, 2023 May 19, 2023 June 20, 2023 July 20, 2023 August 18, 2023 September 20, 2023 October 20, 2023 November 20, 2023 December 13, 2023
What's the maximum CCB payment I can get?
As of 2022, the maximum CCB benefit payment is $6,833 per year per child under 6 years of age, and $5,765 per year per child 6-17 years of age. Of course, these numbers are dependent on loads of factors, such as your household income, the number of children you have, your custody status and more. You can quickly find out how much you're likely to get by using the government's child and family benefits calculator, which you can find here.
Can I receive other benefits for my child?
Yes! There are several other provincial child benefit programs, and many of them work along with the CCB. This means you can potentially receive these benefits in addition to your CCB payments. Here are some of the provinces that provide child benefit programs in addition to the CCB:
In addition, in 2020 Alberta created the Alberta Child and Family benefit program, which is a combination of their previous programs, the Alberta Family Employment tax credit and the Alberta Child Benefit. Quebec offers several child benefit programs:
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Home > Child Tax Benefit Payment Dates 2023 | {
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Christmas in July: National Tree Competition Comes to Michigan
PHOTO: Michigan tree growers are hoping for host state luck this year, as the nation's top Christmas tree growers meet in Allegan to compete for the honor of providing this year's official White House Christmas tree. Photo courtesy of the Michigan Christmas Tree Association.
ALLEGAN, Mich. - It may be July, but it's still the most wonderful time of the year for the nation's top Christmas tree growers, who are bringing their finest specimens to Michigan to vie for the honor of providing this year's official White House Christmas tree.
Rick Dungey, executive director of the National Christmas Tree Association, says the selection is a rigorous contest, with five pages of specifications and three separate rounds of judging.
"They want the tree to go exactly to the top of the ceiling and that measurement is 18-and-a-half foot," says Dungey, "so they can't pick a 17-foot tree or even an 18-foot tree."
Because it is so early in the year, a White House representative will go to the winning tree farm later in the season to select the official tree that will be placed in the Blue Room. Michigan is the nation's third largest producer of Christmas trees, with more than 38,000 acres of Christmas tree farms.
Dungey says a high profile tree like the one for the White House isn't just ceremonial. It also helps spread the word about the environmental benefits of real Christmas trees. He feels younger consumers are leading the charge on that front.
"I think they know that agricultural products, particularly Christmas trees, can be sourced locally in most places around the country, and they always know it's better to use a natural product, a renewable resource that's easily recycled, over a PVC, non-biodegradable, plastic and metal thing that's going to end up in a landfill," he says.
Michigan growers have been selected to provide the official White House tree on several occasions, most recently in 1985. The judging will be done by a panel of growers, industry experts, and consumers at Peterson's Riverview Nursery in Allegan on Friday and Saturday.
Mona Shand, Public News Service - MI | {
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At the end of 2004 it was obvious Science completely ignored the book and the articles although no scientist, editor, science journalist or others were able to present a single valid argument why the proposed paradigm was invalid.
It became clear that Science, for whatever reasons, didn't want to consider to correct mistakes made in the past. Therefore I introduced this chapter so novices could read and comprehend based on simple arguments why the Relativity Theory and Quantum Mechanics are incorrect theories.
In Part I the Special Relativity Theory is refuted with simple straight forward arguments.
In Part II the arguments why all theoretical conclusions of Quantum Mechanics are false is given.
In Part III it is argued and demonstrated that with ether all physical phenomena can rational, without contradiction, be explained.
In Correspondence you can read the "arguments" of scientists, referees and editors why the articles were rejected. | {
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Chris has been an advocate for DaVinci Education since his days as a super user at the University of North Carolina School of Medicine, where he worked for seven years prior to joining our team. An avid fan of auto races, Chris can't help describing Leo as "Formula One," referring to what he considers to be the software system's world-class engineering and capabilities.
At UNC, Chris first managed the medical school's evaluation and management system as Software Technician and later became Business System Analyst/IT Project Manager. Now Chris enjoys being on the other side, advising clients on best practices with Leo and their program management in general. He also contributes to ongoing product development discussions, leveraging his valuable insights as a former medical school administrator. Chris says, "It's a very rewarding environment working at DaVinci Education. It's honest, it's matter-of-fact, and things move forward quickly. And if someone does their job really well, they're quick to get praise. I believe in the product and in the team, it's a great place to be."
As a middle school student, Chris was once hired to build four hundred computers from scratch. He went on to earn a bachelor's degree in business management, with minors in accounting and economics, from North Carolina State University. In his down time, Chris continues to follow races every chance he gets, and recently took his mom to the Indy 500, knocking one off her bucket list as well. Originally from Rutherford County, Chris is happy to have made his home in Durham, NC.
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Fill in the fields on the left. When you are ready to edit the size and position click the little pencil edit button at the end of the text box. This will create a control box around the text. You can then resize and move the text accordingly.
DO NOT CLICK AND DRAG THE TEXT BEFORE CLICKING THE EDIT PENCIL ON EACH FIELD. | {
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Because the simple truth is, that I/ we live from licensing rights to photo usages - not by giving them away.
The web makes it awfully easy to simply copy and re-use images elsewhere - without ever properly licensing them. Of course this is illegal.
I believe I have high-quality images to offer. To safeguard against unauthorized use of my images, I opted for applying watermarks, even though I understand that this is controversial.
While I aimed at making the watermark somewhat unobtrusive, still it needs to be present and visible enough so that the image cannot be used.
It's not an easy decision, since it brings about visual noise for honest viewers, but I do hope for your understanding - and am open for your feedback.
If you are interested in finding out more, you can read my article on copyright basics.
Customers can view all images without watermarks. Just log in here, or contact me for details.
As a photographer I am of course interested that I can be contacted, for cases where images have been temporarily saved and which are to be used and licensed later. Metadata does not always remain intact in this process, but through the website address embedded in the image I can always be reached.
If you like particular images and want to use them: please simply contact me with your licensing request, or look at some of the images that are available for download from the stock agencies I work with.
Thank you - and have fun browsing further! | {
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Llanbradach Follies artwork unveiled
News | Richard Gurner | Published: 07:41, Friday December 18th, 2009.
The Mayor joins members of the local community at the unveiling of the Llanbradach Follies.
Two eye-catching five-metre high towers have been unveiled in Llanbradach.
Artist Kay Aplin has created the spectacular towers called Llanbradach Follies and they have already become a landmark in the village since being unveiled by Councilor John Evans, the Mayor of Caerphilly County Borough Council.
Covered in 2,000 brightly coloured tiles, the follies are based on the local imagery, history, culture and stories of the area.
Llanbradach Councillor Colin Mann said: "The follies represent the finishing touch to the regeneration work in the centre of Llanbradach which has been ongoing for several years now. We are grateful to all the people who have worked very hard to bring about this improvement to our village."
The artwork was funded by Llanbradach and Pwllypant partnership, The Arts Council of Wales and Caerphilly County Borough Council and was project managed by Caerphilly Arts Development.
A spokesperson for Arts Council of Wales said: "This ambitious public art commission in Llanbradach had a strong community involvement as local people developed the themes for the final work with the artist, Kay Aplin.
"We hope that the sculpture will become a much loved feature which will create a strong sense of pride and identity in the area."
Ms Aplin said: "This is my biggest and most spectacular commission to date and one that will hopefully continue to inspire and delight the community of Llanbradach for many years to come.
"It's been 18 months since I first began to design the towers, in conjunction with the local community, and I am very excited to see them finally being installed."
What do you think of the follies? Let us know below. | {
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California universities using SAT for admissions are violating civil rights, lawsuit claims
By Li Cohen
December 10, 2019 / 10:16 PM / CBS News
The University of California is being sued for requiring incoming students to take the SAT and ACT. The lawsuit claims that the tests have a well-known "discriminatory effect" and "exacerbate the inequities" for underrepresented students.
The lawsuit says the University of California (UC) is legally obligated to provide equal access to all students. The SAT and ACT, the lawsuit says, "reflect demographic and socioeconomic characteristics like family income, parental education and race" instead of measuring "academic ability or mastery of curriculum."
The College Board, the organization behind the SAT, released a 2019 assessment of the SAT/PSAT in California that found 45% of white students scored 1,200 or above, while 12% of Latinx students and 9% of Black students got the same score. Parental education levels were also directly related to student scores — only 21% of test-takers whose parents did not receive a high school diploma met SAT benchmarks while 77% of those whose parents have graduate degrees met benchmarks.
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While UC does not have minimum test score requirements, applicants are required to take either the ACT with writing or the SAT exam.
"Applications should keep in mind that when selecting students, competitive campuses and programs look for applicants who have excelled academically," its website states.
The minimum average score for reading at the nine UC undergraduate schools is 580; for math the minimum average score is 579. White and Asian students are the only race demographics who met this standard in the 2019 report.
The lawsuit was filed on behalf of six organizations and four students "whose ability to access public higher education has been hindered by UC's SAT or ACT score requirement."
Public Counsel, the pro bono legal service representing the students and organizations, posted about the filing Tuesday on Instagram. They quoted attorney Mark Rosenbaum as saying, "... if the SAT means anything, it stands for 'Socio-Economic Advantage Test' — it is illegal."
"Use of the SAT and ACT is not just indefensible policy - if the SAT means anything, it stands for "Socio-Economic Advantage Test" - it is illegal. It is illegal wealth and race discrimination that damages the futures of tens of thousands of deserving students each year who could excel at UC campuses of their choice and that are best suited to their strengths and passions. As this nation's preeminent public institution of higher education, the UC system has no more constitutionally sacred obligation than to ensure equal access to all of California's young persons, to serve as a beacon of hope and opportunity. By its reliance on the SAT and ACT, the UC system subverts this mission and makes its campuses havens for concentrated privilege." - Mark Rosenbaum, Directin ATtorney with Public Counsel. Why we filed a lawsuit against the University of California for discriminatory use of the SAT/ACT in admissions today. 🔹Link in bio to read the @npr story🔹#highereducation #educationrights #JusticeforAll #educationforall #standardizedtesting #SAT
A post shared by Public Counsel (@public_counsel) on Dec 10, 2019 at 4:44pm PST
One of the plaintiffs is 17-year-old Kawika Smith, a African American student from Verbum Dei High School. According to the lawsuit, Smith was homeless from second through eighth grade, is a rape survivor, experienced domestic violence and suffered from the loss of his brother his junior year of high school. These circumstances, the lawsuit says, prevented him from getting adequate test preparation and thus, was ineligible to be admitted to UC.
Smith posted a photo of himself on Instagram, originally posted by Public Counsel, saying "the SAT score does nothing for people like me."
"The SAT doesn't account for all the ways I'm stepping up as a leader in my community or how I'm healing from trauma and growing from my lived experiences," he posted. "And it doesn't say anything about how well I can do in college or whether I can achieve my dreams."
#Repost @public_counsel "The SAT score does nothing for people like me. The SAT doesn't account for all the ways I'm stepping up as a leader in my community or how I'm healing from trauma and growing from my lived experiences. And it doesn't say anything about how well I can do in college or whether I can achieve my dreams." | Kawika Smith, senior at Verbum Dei High School. Basing college admissions decisions on SAT and ACT scores amounts to deciding students' future based on their race and socioeconomic status and not on individual merit. Today, on behalf of three students including Kawika, five nonprofits and the Compton Unified School District, our legal team including lawyers from Scheper Kim & Harris, Equal Justice Society, Miller Advocacy Group, and Olivarez Madruga Lemieux O'Neill, LLP announced our formal request to the University of California Board of Regents that the UC system cease use of SAT and ACT test scores in admissions decisions. The Board of Regents will have ten days to respond, and if the practice is not stopped, we will file a civil rights lawsuit against the UC for knowingly creating barriers to higher education for students of color and students with disabilities.
A post shared by Kawika Smith (@kawika_smith) on Oct 29, 2019 at 5:20pm PDT
This barrier, the lawsuit claims, violates the state's equal protection guarantees, state education laws and civil rights laws. More than 1,000 universities and colleges have removed the requirement from their application.
"... [T]his policy illegally discriminates against applicants on the basis of race and wealth, and thereby denies them equal protection under the California Constitution," the suit claims.
UC Berkeley chancellor Carol Christ said at a forum November 23 that using these standardized exams for college admissions decisions is unfair, according to The Associated Press.
"They really contribute to the inequities of our system," Christ said.
UC Santa Cruz chancellor Cynthia Larive reportedly said she also supports removing the testing requirement, according to AP.
"At Santa Cruz, we use holistic admissions to try to evaluate the student within a broader context, which cannot be simply reduced to a number," she said.
Since January, the university system's Standardized Testing Task Force has been looking at how standardized testing is being used for admission. No reports have been made available.
First published on December 10, 2019 / 10:16 PM | {
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Articles tagged with: The crossing
The French prize of the Best Foreign Book was awarded to Yazbek's The Crossing yesterday!
[30 Nov 2016 | 3 Comments | 265 views]
This is a translation of an article by Gregoire Lemenager for Nouvel Observateur.
The prize for the Best Foreign Book (Meilleur Livre Etranger), the jury of which includes critics and publishers, is awarded on 29 November. There are two awards, one for fiction and one for non-fiction.
In the non-fiction category, the prize was awarded to Samar Yazbek's The Crossing.
Yazbek's "Les portes du néant" ("The crossing") is on the shortlist of the prestigious French Médicis award
There are 14 titles on the shortlist, and the winner will be announced on October 10th. The Prix Médicis aims at giving recognition to authors whose fame does not match their talent. The prize was awarded to authors such as Jean Echenoz, Philippe Sollers, Sorj Chalandon or Marie Darieussecq in the past.
Earlier in the summer, Samar Yazbek was given the title of"Chevalier de l'Ordre des Arts et des Lettres", or "Knight of literature", by the French ministry of culture. This title is a sign of recognition of the services Yazbek …
A "formidable" narrative – Le Monde des Livres honours Yazbek's The Crossing
[21 Apr 2016 | No Comment | 146 views]
Jean Hatzfeld for Le Monde des Livres, April 15 2016
Les Portes du néant, à la frontière turque, s'ouvrent une première fois sur la route qui mène à la région d'Idlib, dans le nord-ouest de la Syrie. Samar Yazbek les franchit en août 2012, en se faufilant dans un trou creusé sous des barbelés. Une voiture l'attend, qui traverse la nuit sur un fond sonore de bombardements, avec à l'intérieur Maysara et Mohammed, deux frères d'armes rebelles : ses anges gardiens.
Le Nouvel Observateur: Yazbek's The Crossing "makes her comparable to Orwell"
Gregoire Lemenager, for Le Nouvel Observateur, March 20th 2016
(…) She who until now scanned the gray areas of the good Damascene society in daring novels ( "Cinnamon" tells the homosexual relationship of a bourgeois with her housekeeper), then published "In the crossfire" (Buchet-Chastel, 2012) and collects literary awards that applaud her courage.
Liberation draws Yazbek's portrait and reviews The Crossing, a "Colossal work"
By Jean-Louis Le Touzet, for Liberation, March 20, 2016
Photo credit: Mathieu Zazzo, Liberation
Men make war. But a woman, blonde, cat-eyed, 46-year old Syrian of high education was needed to paint Syria's death. No other brush was ever dipped in as many tears to tell the intoxication of brutality in a country under the yoke of a double punishment: that of a totally deranged regime and that of the unbearable cruelty of fanatical Islamists . To be clear, about Syria, we read everything and read nothing. Rarely such a plunging view of demolition was ever published. This is what this … | {
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When you're adding an image, click the "Image Gallery" button to get started. In the "Image Gallery", you can simply click on an image you've used before to add it to the message. To delete an image from your gallery, first hover over the image in question.... I have imported a HTML report into word by opening it (open index.html in Word) and copy / paste the result as an annex into my Doc. It worked fine, except that all the images (200 of them) are actually links to the images on my hard drive.
Add anchors for linking Link back to an anchor In the Document window�s Design view, select text or an image to create a link from. select text or an image you want to link from. (If this is another open document, you must switch to it.) Do one of the following: Click the Point-To-File icon (target icon) to the right of the Link box in the Property inspector and drag it to the anchor you... While linked images have several downsides (discussed in this article), they can be used in cases where e.g. reducing the size of the email is a priority. Below you will find the steps necessary to override Outlook�s default behavior and force it to use a linked/internet image.
It�s nice to spice up your transactional emails with a few images from time to time. Even if it�s just a logo, you�ll find it helps to add a touch of legitimacy to what you�re sending out. However, there�s no one way to do this. Do you link out to the image on a CDN? Do you embed it and... I have imported a HTML report into word by opening it (open index.html in Word) and copy / paste the result as an annex into my Doc. It worked fine, except that all the images (200 of them) are actually links to the images on my hard drive.
I have imported a HTML report into word by opening it (open index.html in Word) and copy / paste the result as an annex into my Doc. It worked fine, except that all the images (200 of them) are actually links to the images on my hard drive.
11/03/2015�� Right click on the image and add hyperlink. Copy the whole table with the image into your outlook message. Note, you may want to remove the border for the table before you copy it to your outlook message. | {
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Dana Zátopková is 96 years old today; her celebrated husband, Emil Zátopek would have been 96 too, since by coincidence they were born on the same day, just a few hours and a hundred kilometres or so apart. Her status as an elder stateswoman of the sport seems to contrast with her beginnings; because apparently Dana was a bit of a tomboy in her youth, dashing around, according to her mother in the most unladylike fashion. But that dynamism (and her mastery of the popular songbook of the period) attracted Emil, and has doubtless contributed to her longevity. Equally, his unbelievably onerous training programme may have contributed to Emil's relatively early death, aged 78, in 2000.
A real 'character' herself, most of her life Dana had to play second fiddle to her ebullient and talkative husband. But she had her own moments in the sun, not least when she won the Olympic javelin title in Helsinki 1952, just after Emil had won the 5000 metres, the second leg (between the 10,000m and the marathon) of his unrepeatable Olympic treble. Even then, Emil had won three golds to her one; and he joked that the 5000m only made it 2-1, and he needed that third victory to emphasise family superiority. But he went a step too far when he attributed her victory to himself. Her riposte is typical of the sense of humour which endures to this day.
Here, beginning with the prelude to the 1952 Olympic javelin final, is the relevant extract from my book on Zátopek, QUICKSILVER*.
'… The final of the women's javelin was due to begin concurrent with the 5000 metres, and as she (Dana) records, the last thing she needed was the sort of cliff-hanger finale that Emil had stage-managed so adroitly. 'That´s terrible, she wrote in their autobiography, 'That Ťopek (chohpek, his pet name) always makes it so exciting that the whole stadium is on its feet. When I see him chasing like that my knees are shaking. With that, I won't throw any distance at all'.
'I was trying to comfort her,' wrote Emil, 'telling her to stay calm, because she'd lost before and I wasn't going to win the 5000 metres anyway. At the finish I recognized, to my delight, my mistake. When I looked around the stadium, I didn't see either Dana or the other javelin throwers. We met in the changing room after the award ceremony. I wanted to ask why the javelin had been delayed but I couldn't get a word in edgeways. She jumped all over me, she was so thrilled. "You really won it! That´s wonderful! Show me the medal!" And there she was, putting it into her bag. For good luck, she said. | {
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PHYSICA STATUS SOLIDI (A) APPLICATIONS AND MATERIALS SCIENCE, Issue 5 2010
E. Sakalauskas
Abstract A comprehensive characterization of the optical properties of wurtzite InN films grown by molecular beam epitaxy on Si(111) substrates is presented. Two types of films are investigated in this work: InN on AlN/Si(111) and InN on GaN/AlN/Si(111). Their properties are compared to a layer deposited on GaN/sapphire substrate. The dielectric function (DF) is obtained from spectroscopic ellipsometry (SE). The infrared studies yield the plasma frequency and thus the electron density, while the interband absorption is probed between 0.56 and 9.8,eV. For InN grown on Si(111) substrate, the absorption onset is slightly shifted to higher energies with respect to the InN film grown on GaN/sapphire which can be attributed to higher electron concentrations. Despite this, strongly pronounced optical transitions due to critical points of the band structure are found in the high-energy part of the DF. It emphasizes the already promising quality of the InN films on silicon. Band-gap renormalization (BGR), band filling, and strain are taken into account in order to estimate the intrinsic band gap of wurtzite InN. For the InN layers on silicon, we get a band gap between 0.66 and 0.685,eV. [source]
MOVPE of InN films on GaN templates grown on sapphire and silicon(111) substrates
Muhammad Jamil
Abstract This paper reports the study of MOVPE of InN on GaN templates grown on sapphire and silicon(111) substrates. Thermodynamic analysis of MOVPE of InN performed using NH3 as nitrogen source and the experimental findings support the droplet-free epitaxial growth of InN under high V/III ratios of input precursors. At a growth pressure of 500 Torr, the optimum growth temperature and V/III ratio of the InN film are 575,650 °C and >3 × 105, respectively. The surface RMS roughness of InN film grown GaN/sapphire template is ,0.3 nm on 2 ,m × 2 ,m area, while the RMS roughness of the InN film grown on GaN/Si (111) templates is found as ,0.7 nm. The X-ray diffraction (XRD) measurement reveals the (0002) texture of the InN film on GaN/sapphire template with a FWHM of 281 arcsec of the InN (0002) , rocking curve. For the film grown on GaN/Si template under identical growth conditions, the XRD measurements show the presence of metallic In, in addition to the (0002) orientation of InN layer. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]
Growth and properties of In-rich InGaN films grown on (0001) sapphire by RF-MBE
PHYSICA STATUS SOLIDI (B) BASIC SOLID STATE PHYSICS, Issue 12 2004
M. Kurouchi
Abstract We have performed detailed investigations of the optical properties of strain-free In-rich InxGa1,xN (0.61 , x , 1.0) films that were grown directly on (0001) sapphire substrates by radio-frequency plasma-excited molecular beam epitaxy. In-composition dependence of photoluminescence peak energy for the InxGa1,xN films, measured at room temperature, exhibited a monotonic and smooth decrease with the increase in the In-composition, approaching to 0.66 eV of a strain-free InN film that was also grown directly on the sapphire substrate. The energy bowing parameter, b was determined to be 1.8 eV using these strain-free InxGa1,xN films. Structural properties of these films are also investigated in detail. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]
Analysis of the local structure of InN with a bandgap energy of 0.8 and 1.9 eV and annealed InN using X-ray absorption fine structure measurements
PHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue 6 2006
Takao Miyajima
Abstract We compared the local structure around In atoms in microwave-excited MOCVD- and MBE-grown InN film which indicates an absorption edge at 1.9 and 0.8 eV, respectively. The co-ordination numbers of the 1st-nearest neighbor N atoms and the 2nd-nearest neighbor In atoms for MBE-grown InN were n(N) = 3.9 ± 0.5 and n(In) = 12.4 ± 0.9, which are close to the ideal value of n(N) = 4 and n(In) = 12 for InN without defects, respectively. By thermal annealing, the structure of MBE-grown InN was changed from InN to In2O3, and the absorption edge was changed from 0.8 to 3.5 eV. However, the microwave-excited MOCVD-grown InN had no structure of In2O3, and had the reduced co-ordination numbers of the 2nd-nearest neighbor In atoms of n(In) = 10.6-11.7. From these results, we conclude that the origin of the 1.9-eV absorption edge of InN is the imperfections (defects) of the In lattice sites of InN, rather than the generation of In2O3, which has a bandgap energy of 3.5 eV. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]
Optical anisotropy of A - and M -plane InN grown on free-standing GaN substrates
P. Schley
Abstract Wurtzite A - and M -plane InN films were grown by molecular beam epitaxy (MBE) on free-standing GaN substrates. Spectroscopic ellipsometry (SE) in the photon energy range from 0.56 up to 15,eV was applied in order to determine the ordinary and extraordinary complex dielectric function (DF) of InN. A distinct optical anisotropy was found over the whole energy range. The extraordinary absorption edge in comparison to the ordinary one is shifted to higher energies confirming previous studies. The investigations in the upper vacuum-ultraviolet (VUV) spectral range (9.5,15,eV) yielded transition energies for four critical points (CPs) of the band structure (BS) which have not been observed so far. [source]
Doping-dependence of subband energies in quantized electron accumulation at InN surfaces
T. D. Veal
Abstract Electron tunnelling spectroscopy is used to investigate the quantized electron accumulation at the surfaces of wurtzite InN with different doping levels. The tunnelling spectra of InN-oxide-tip junctions recorded in air at room temperature exhibit a ,0.6 V plateau, corresponding to the band gap of InN, and a gap between onsets of 1.3 V, consistent with the separation between the valence band maximum and the pinned Fermi level at the oxidized InN surface. Also observed within the tunnelling spectra are additional features between the conduction band minimum and the pinned Fermi level. These features are attributed to surface-bound quantized states associated with the potential well formed by the downward band bending at the InN-oxide interface. Their energetic positions are dependent upon the doping level of the InN films and coincide with calculated subband energies. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]
High-quality InN grown on KOH wet etched N-polar InN template by RF-MBE
D. Muto
Abstract We have succeeded in dramatically decreasing the density of dislocations in InN by regrowing InN films on micro-facetted N-polar InN templates. The micro-facetted N-polar InN templates were formed by wet etching in a 10 mol/l KOH solution. InN films were regrown on the micro-facetted N-polar InN templates and on flat surface N-polar InN templates for comparison by radio-frequency plasma-assisted molecular beam epitaxy. InN regrown on micro-facetted InN had considerably smaller twist distribution than that grown on the flat InN templates. From transmission electron microscopy observation, it was confirmed that the InN grown on the micro-facetted InN template had much lower density of dislocations than that grown on the flat InN template, and moreover the propagation of edge dislocations was almost completely terminated at the interface between the regrown InN and the micro-facetted InN template. Based on the results, we propose that regrowth of InN on micro-facetted InN templates is an effective way to obtain high-quality InN films. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]
Stoichiometry effects and the Moss,Burstein effect for InN
K. S. A. Butcher
Abstract We examine the Moss,Burstein effect for InN and demonstrate an independent method for determing its magnitude for high carrier concentration material. Consequently it is shown that the extent of the Moss,Burstein effect is less than 0.72 eV for a high carrier concentration sample with a 1.88 eV absorption edge. Early results are also provided for high band-gap low carrier concentration InN films that can be grown reprodcibly, vindicating the work of early groups in the field. The role of stoichiometry is examined in relation to point defects that appear to be common to many forms of InN. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]
Raman and transmission electron microscopy characterization of InN samples grown on GaN/Al2O3 by molecular beam epitaxy
PHYSICA STATUS SOLIDI (B) BASIC SOLID STATE PHYSICS, Issue 7 2006
J. Arvanitidis
Abstract Raman spectroscopy and transmission electron microscopy were employed to study the vibrational properties and the microstructure of epitaxially grown InN films on GaN/Al2O3 templates. The variations of the InN lattice constants, as deduced by electron diffraction analysis, along with the red-shifted E22 mode frequency reveal that InN films exhibit residual tensile stress, strongly dependent on the epilayer growth temperature. Threading dislocations are the dominant structural defects in the films, having a density in the order of 109,1010 cm,2. Profile analysis of the E22 Raman peak by means of the Spatial Correlation Model provides useful information concerning the effective mean length for free phonon propagation (L), which is a measure of the structural quality of the samples. In all the studied samples, L monotonically increases with decreasing threading dislocation density of pure screw and mixed type character. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]
Effective mass of InN estimated by Raman scattering
PHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue 7-8 2010
Jung Gon Kim
Abstract We have estimated the longitudinal effective mass (m,) of electron in n-type InN films by Raman scattering. The samples were grown by MOVPE (metal organic vapor phase epitaxy) with free carrier concentration of n =6.7×1018 -9.9×1018 cm -3 according to Hall measurement. A weak Raman signal observed at ,430 cm -1 at room temperature was sharpened and shifted to higher frequency toward the A1(TO)-phonon mode at 447 cm -1 with increasing n. This mode was assigned to the lower branch (L - ) of the longitudinal-optic-phonon-plasmon-coupled (LOPC) mode. The line shape was carefully analyzed by a semi-classical line-shape fitting analysis assuming deformation potential and electro-optic coupling mechanisms for the light scattering process. A line-shape fitting analysis was conducted by adjusting three major parameters; electron density, effective mass and plasmon damping rate. The analysis well reproduced values of electron density and mobility deduced by Hall measurement. Electron effective mass of m,*/m0 = 0.05 (±0.01) was also obtained as the best-fit parameter. The result agrees well with previous data obtained by other optical methods. (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]
RF-MBE growth of InN on 4H-SiC (0001) with off-angles
Misao Orihara
Abstract We have grown InN on 4H-SiC (0001) substrates with various off-angles by RF-N2 plasma molecular beam epitaxy (RF-MBE). Scanning electron microscope observation revealed that InN films grown on 4H-SiC (0001) substrates with off-angles of 4° and 8° are very smooth and that there are no voids which have often observed for InN epitaxial layers. X-ray diffraction reciprocal space maps for InN grown on 4H-SiC (0001) showed that the c-axes of InN grown on 4H-SiC 4° and 8° off substrates are inclined by 0.35° and 0.8°, respectively, toward the misorientation of the substrate while the c-axis of InN is parallel to that of 4H-SiC for the on-axis substrate. Strong PL peak was observed from InN grown on 4° off substrate at 0.68 eV at 15 K. The PL peak was clearly observed even at room temperature and simply shifted to lower energies with increasing temperature. The difference in the PL peak energy between at 15 K and 300 K was 20 meV, which is reasonable taking into account the difference in the thermal coefficients of InN and SiC (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]
Photoluminescence of cubic InN films on MgO (001) substrates
T. Inoue
Abstract We have studied photoluminescence from cubic InN films grown on MgO substrates with a cubic GaN underlayer by RF N2 plasma molecular beam epitaxy. A single PL peak was observed at 0.47 eV. By analyzing the reflectance spectra of cubic InN films, we could derive the refractive index and extinction coefficient, and found the band gap energy of cubic InN is 0.48 eV, indicating that the PL peak observed at 0.47 eV is due to the interband transition of cubic InN. The difference in the PL peak energy between hexagonal and cubic InN is in good agreement with that predicted by ab-initio calculations. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]
NH3/TMI molar ratio dependence of electrical and optical properties for atmospheric-pressure MOVPE InN
A. Yamamoto
Abstract The electrical and optical properties for atmospheric-pressure MOVPE InN have been studied as a function of NH3/TMI molar ratio during the growth. Residual carrier (electron) concentration is decreased with increasing NH3/TMI molar ratio. PL peak energy is also shifted to a low energy side with increasing NH3/TMI molar ratio. Hall mobility of InN is almost independent on NH3/TMI molar ratio and is rather decreased at a high NH3/TMI molar ratio. The highest mobility is obtained for a sample grown at a relatively low NH3/TMI molar ratio. The grain size of the InN films is decreased with increasing NH3/TMI molar ratio. The lowest carrier concentration of 4.5×1018 cm,3 and highest mobility of 1100 cm2/Vs obtained here are the best data for MOVPE InN ever reported. Based on these results, the most probable candidate for donors and the dominant carrier-scattering mechanism for atmospheric-pressure MOVPE InN are discussed. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]
Growth of InN on 6H-SiC by plasma assisted molecular beam epitaxy
April S. Brown
Abstract We have investigated the growth of InN films by plasma assisted molecular beam epitaxy on the Si-face of 6H-SiC(0001). Growth is performed under In-rich conditions using a two-step process consisting of the deposition of a thin, low-temperature 350 °C InN buffer layer, followed by the subsequent deposition of the InN epitaxial layer at 450 °C. The effect of buffer annealing is investigated. The structural and optical evolution of the growing layer has been monitored in real time using RHEED and spectroscopic ellipsometry. Structural, morphological, electrical and optic properties are discussed. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] | {
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Jeanine Planques-Kleykens (née le 8 août 1925 à Maisons-Laffitte et morte le 16 août 1994) est une designeuse textile belge. Elle se consacre pendant plus de 25 ans à la création de textiles, elle crée de nombreux motifs et divers thèmes d'inspirations pour la firme Essix et s'occupe également des tissus d'ameublement pour la société Lattoflex. Elle contribue à établir un lien créatif entre les industriels et le public dans le domaine du textile en Belgique. Jeanine Kleykens a également enseigné à l'ENSAV.
Biographie
Jeanine Kleykens est étudiante à La Cambre (ENSAV) avant d'y devenir professeure, elle commence comme artisane et, dans les années 1960, travaille pour l'industrie textile en tant que designeuse. Que ce soit pour recouvrir des sièges de voitures ou réaliser des tentures, des canapés, des maillots de bain, des toiles à matelas, elle touche à une grande variété de domaines. Jeanine Kleykens contribue grandement à l'émancipation du textile sous des formes diverses et colorées.
Elle donne des cours à l'ENSAV, à partir du 22 octobre 1967, de tissage, tapis, tapisserie et de gravure et illustration du livre.
Elle propose de nombreux stages à ses étudiants afin de les faire évoluer et s'épanouir, dès 1968-69, elle demande une série de courts séjours à l'École nationale d'art décoratif d'Aubusson. Plusieurs de ses étudiants ont remporté des premiers prix notamment au Festival international du lin à Monte-Carlo dans la section ameublement.
Elle travaille en parallèle de son statut de professeure dans le département des ventes de 1967 à 1973. Elle est employée à Solintex.
Jeanine Kleykens est créatrice consultante et professeure à l'Institut Bischoffsheim et dirige le Centre de recherche de la Fondation de la tapisserie de la Communauté française (depuis 2012, TAMAT, Centre de la tapisserie, des arts muraux et des arts du tissu de la Fédération Wallonie-Bruxelles). Elle y dirige l'atelier "Textile design et art du tissu".
Elle fait partie des membres du jury pour l'exposition « d'artisanat belge » organisé à la Grand-Place de Bruxelles en mai 1983.
Par la suite, elle crée son propre bureau dans lequel elle travaille en collaboration avec Marianne Oosthoek et Fabienne Colet, Andy Jacobs et Léon Kleykens son mari.
Œuvres
Jeanne Kleykens est créatrice consultante chez Essix où elle conçoit la collection annuelle de linge de lit de 1968 à 1992.
Références
Designer belge
Naissance en août 1925
Naissance à Maisons-Laffitte
Décès en août 1994
Artiste formé à La Cambre | {
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The beautiful story of the Nativity is one that never ceases to inspire. Now the passion of that very first Christmas comes to life like never before in the enchanting Thomas Kinkade Nativity Garland Set. Available only from the Bradford Exchange, Hawthorne Village Division, this Market First lighted garland set recreates the events of that special night through the glory of seven sculpted figures, including the Holy Family with illuminated Creche, Three Kings, angels and more.Expertly handcrafted with a wealth of intricate detail, this collectible Nativity garland set is a welcome addition to your Thomas Kinkade Christmas decor. Shimmering with the warm glow of over 60 holiday lights and the gleam of 22K-gold accents, this Nativity set makes quite an impression at a dramatic 4 feet long. Sure to add beauty and meaning to every Christmas season, this Thomas Kinkade Christmas decoration is not to be missed. Strong demand is expected, so order now! | {
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DENVER (CBS4) – A school in northeast Denver had to be put on lockdown Monday afternoon while police looked for a man who was possibly armed with a gun.
Harrington Elementary located at 2401 East 37th Avenue was on lockdown for approximately 10 minutes while police searched for the suspect.
According to Sonny Jackson with Denver police, the suspect had pointed a gun at a group of people near the 3200 block of Dahlia Street.
Harrington Elementary had been doing a planning day so no students were at the school.
Police believe the suspect left the area and the search continues. | {
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Home » Women » What You Need to Know About Meningitis
What You Need to Know About Meningitis
July 18, 2017 Igor Abolnik, MD
Meningitis is a dangerous infectious disease that crops up year after year, much like the flu, and spreads very quickly. What do you need to know so you can protect yourself and your loved ones from this aggressive, potentially life-threatening disease? We spoke with Igor Abolnik, MD, an infectious diseases physician at St. Joseph Health Medical Group, to find out.
Q. There have been regular reports in the news through last winter and spring about meningitis cases cropping up in both Northern and Southern California. For example, through July 7, 2017, ten cases of invasive meningococcal disease--including two fatalities--have been found in Los Angeles County this year, exceeding the previous five-year average. All but one of the cases occurred between January and March. Is this an outbreak that people need to be concerned about?
A. There has definitely been an increase as compared to previous years. Last winter was harsher than usual, resulting in people staying inside more than normal. This meant people were spending more time in close contact with others and, because of the contagious nature of meningococcal meningitis, the disease spread very quickly. When you combine winter weather with people in close proximity, like a school or office, the risk of any infectious disease rises. Again, I would not consider these recent cases an epidemic. However, meningitis outbreaks--even if seemingly limited in scope--are serious public health concerns. When meningitis is afoot, as it was earlier this year, it is important to understand the nature of the disease, the symptoms, how it spreads, and how to protect yourself against it.
Q. What are the different kinds of meningitis?
A. There are five different types of meningitis; however, three are very rare. The two most common and basic strains are:
1. Bacterial: The first and most dangerous is bacterial meningococcal meningitis. It can be deadly, even if it's detected quickly. The bacteria get into the bloodstream and cause swift, widespread infection and inflammation of the brain and spinal cord. Bacterial meningitis proves fatal in 5-15 percent of people who contract it, even with prompt medical treatment.
2. Viral: Viral meningitis is more common and much less dangerous. Most cases stem from enteroviruses (which are transmitted through the intestines), measles, mumps, chicken pox or viruses from insects. In most cases, it resolves on its own within seven to 10 days without treatment.
Q. How is meningitis most commonly spread?
A. Bacterial meningococcal meningitis spreads very easily through direct contact, like coughing, sneezing or saliva transfer (such as kissing or even mouth-to-mouth resuscitation). Viral meningitis spreads most commonly through fecal contamination, or secretions of the eyes, nose or mouth. The best way to prevent viral meningitis is frequent and proper hand washing – and, of course, vaccination.
You can't get either type of meningitis from casual contact or from simply breathing the air that an infected person has breathed. To become infected yourself, you have to have close and sustained contact with an infected person, or you have to share something with that person that can spread germs, like tissues, towels, lip gloss, makeup, eating utensils or drinking cups.
Q. We're told that meningococcal meningitis symptoms resemble the flu – is this true? What are the primary symptoms of bacterial and viral meningitis?
A. It's not accurate to say that the symptoms are the same, but people who have the flu might mistakenly associate meningitis symptoms as simply part of their flu. Meningitis is a potential complication of the flu, especially for people with asthma, diabetes or heart disease, but meningitis has its own set of recognizable symptoms: a sudden high fever, a stiff neck (which usually doesn't occur in flu), and mental confusion or other unusual changes in cognitive ability. Taken together, these are significant warning signs of a potential case of meningococcal meningitis, even more so if accompanied by nausea, bad headaches, rashes or pain all over the body.
If you exhibit these symptoms, you should go to the emergency department immediately. Time is of the essence in treating meningitis. In fact, I recommend larger, urban hospitals rather than smaller, rural hospitals if you have the option. Facilities in large metropolitan areas tend to be better equipped and have a larger selection of medications on hand. This will give your doctors the quickest access to the widest range of antibiotics. You should also see your doctor right away if you've recently been in close contact with a person who has just had meningitis.
Q: What is the treatment for meningitis?
A. Antibiotics. I cannot stress enough how important it is to been seen by a physician and obtain the proper antibiotics without delay. Meningitis is a well-understood disease and full recovery is possible. However, the consequences of an untreated bacterial meningitis infection, even if not fatal, can include lifelong and disabling after-effects like hearing loss, sight problems and brain injury.
Q. How can meningitis be prevented?
A. There's no question that prevention is a crucial first step in keeping isolated cases from becoming an outbreak. First and foremost, you should protect yourself from all types of meningococcal meningitis with the appropriate vaccinations. Adults who have an immune system disorder, or who live in or travel to an area where meningitis is common, or who have been exposed to someone with meningitis, should be especially sure to ask their doctor about a vaccination. There is a new recommendation from the Centers for Disease Control and Prevention (CDC) for all men who have sexual relations with other men to get the meningococcal meningitis vaccination. There is also a vaccination available specifically for people with diabetes or who are over the age of 65. These people are at a higher risk of pneumonia and sepsis, which weakens the immune system and makes them more vulnerable to meningococcal meningitis.
Second, you should not share items that can spread germs through saliva like food, drinks, cups, utensils or toothbrushes.
Lastly, maintaining a healthier overall lifestyle can enhance your immune system's ability to protect you not just from meningitis, but a wide range of disease. Don't smoke, drink alcohol only in moderation, eat a nutritious diet, and exercise regularly.
Q. How can I protect my children from meningitis?
A. I'm an adult infectious disease specialist; however, the CDC recommends meningococcal vaccinations for all children ages 11 to 12, along with a follow-up booster shot at age 16. Ask your pediatrician or family doctor about the right immunization schedule for your kids. Children who are about to go to summer camp, for example, may need a meningitis vaccination due to the shared sleeping and dining arrangements. In addition to vaccination, you can help protect your kids from meningitis by teaching them good personal hygiene, like frequent hand-washing, and instilling the same habits that can keep their immune system healthy like they can yours, such as eating a balanced diet, getting plenty of sleep, and staying physically active.
Q: How can I find out if I've been vaccinated? If not, can I get the vaccination?
A. Your primary care physician can check your health records and tell you if you've received the vaccination. If you haven't been vaccinated, he or she can give you the vaccination right in the physician's office. Women who are pregnant or breastfeeding, and people with severe allergies, need to be medically cleared before receiving certain meningococcal vaccinations; but, in general, everyone can and should be vaccinated. Your doctor can advise you about which specific vaccines are right for you and when you should get them.
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DP/30 Archive for September, 2011
DP/30: Melancholia, actors Alexander Skarsgard, Kiefer Sutherland
By DP30 - Thursday, September 29th, 2011
Lars von Trier's Melancholia is rolling on to the NY Film Festival in the next week. We chatted with two of the stars, Alexander Skarsgard and Kiefer Sutherland, about working with Lars, pushing the envelope as actors, and the film's amazing cast.
DP/30 @ TIFF 2011: Take Shelter, wr/dir Jeff Nichols, actors MIchael Shannon, Jessica Chastain
Jeff Nichols' second feature, like his first, Shotgun Stories, is thrilling and challenging audiences. By his side again is Michael Shannon, who has risen from obscurity to awards bait actor. And by Mike's side, Jessica Chastain, who has risen from obscurity to ubiquitous awards bait just this year. Meet the trio.
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Kawakawa throat spray for sore throats in a generous 50ml spray dispenser. $32.95 plus postage and packaging.
An Essential handy pack containing one of each of the Everyday Balm, the Wound Warrior and Aches and Pains in convenient 30 gram jars. A perfect gift!
"I would just like to say thank you so much for your shampoo bars I have been trying for ages to find a good organic one that doesn't make my hair oily or my scalp itchy! Also, my hair has stopped falling out. Thank you thank you :)"
My leg was injured in a fall. It had hurt for 2 weeks, even having taken remedies for it. Trish suggested putting Aches and Pains cream onto the affected site three times a day. The pain felt like the bone was bruised, and the leg was twisted, so I was limping. Then within 3 days of doing this regime my pain disappeared and hasn't returned, even when I am on my feet all day at my job. Thank you again.
Both my girls suffer with eczema and I am always looking for solutions to this. While I believe this is an internal problem that I need to get to the bottom of, the everyday balm really keeps the nasty itchy skin to a manageable level and I am very grateful for this. I have tried many things and it is the best product ever. | {
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An introduction to the development of Christianity from social, cultural, and institutional perspectives from its origins in the first century to its fragmentation during the Reformations in the 16th century. A special focus of this investigation will be the changes Christianity underwent as it spread through different cultures, evolved over time to new contexts, and reacted to political changes. It will trace the impact of varying cultural forces such as Greco-Roman influence, the conflict between Catholic Christianity, Orthodox Christianity, and Islam during the Crusades, and the Medieval and Renaissance papacy which led to the Reformations. | {
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2019 STEM Institute – Keynote Speakers – NYS STEM Education Collaborative, Inc.
advancing sustainable energy solutions and environmental technology innovation. In June 2017, Gov. Andrew Cuomo nominated President Collins to sit on the board of trustees of the NYS Higher Education Services Corp. (HESC) as a representative of private higher education and was approved by the New York Senate in June 2018. New York State's higher education student financial aid agency. In May 2014, President Obama nominated Dr. Collins to serve on the Advisory Board of the Saint Lawrence Seaway Development Corporation. NY Governor Andrew Cuomo appointed Dr. Collin to serve as co-chair for the North Country Regional Economic Development Council from July 2011 – February 2019. Dr. Collins served on a commission, established by Governor Cuomo in November 2012 to investigate and study utility companies' storm preparation and management; and to recommend reforms to overhaul regulation of the entire system to better deal with emergencies. He is the also the president of the Seaway Private Equity Corporation that invests in new technology companies based in St. Lawrence County, New York; and is a member of NYSERDA's Technology & Market Development Advisory Committee which provides technical and policy guidance to NYSERDA on energy and environmental research and market development initiatives.
In service to the higher education sector, President Collins is the past chair of the National Association of Independent Technological Universities and a chair emeritus of New York's Commission of Independent Colleges and Universities. In addition, he serves on the boards of the CenterState Corporation for Economic Opportunity and the NYS Business Council.
Robert Rogers is a SUNY Distinguished Teaching Professor of Mathematics in the Department of Mathematical Sciences at SUNY Fredonia. His original area of research is Operator Theory, but he has since focused more on applying the history of mathematics to the teaching of mathematics. He is also interested in bringing more STEM applications into mathematics courses. He is coauthor (with Dr. Eugene Boman, Penn State – Harrisburg) of the open source real analysis textbook "How We Got from There to Here: A Story of Real Analysis" available through the SUNY Open Textbook Program. He is a past chair and governor of the MAA – Seaway Section, a past president of the Association of Mathematics Teachers of NYS, and a member of the governing board the NYS STEM Education Collaborative. He is former editor of the NYS Mathematics Teachers' Journal. He is a recipient of the SUNY Fredonia President's Award for Excellence in Teaching, the MAA – Seaway Section Clarence F Stevens Distinguished Teaching Award, and the MAA Distinguished Service Award – Seaway Section. He is a member of the NYS Mathematics Educators' Hall of Fame.
Dr. Kristina M. Johnson joined The State University of New York as its 13th chancellor in September 2017. Immediately prior to joining SUNY, Dr. Johnson was co-founder and CEO of Cube Hydro Partners, LLC, a clean-energy infrastructure company focused on building and operating hydropower plants in North America. She also previously served as Under Secretary of Energy at the U.S. Department of Energy. Dr. Johnson served as provost and senior vice president for Academic Affairs at Johns Hopkins University from 2007 to 2009, and as dean of the Pratt School of Engineering at Duke University from 1999 to 2007. Dr. Johnson received her BS, MS, and PhD in electrical engineering from Stanford University. After a NATO post-doctoral fellowship at Trinity College in Dublin, Ireland, she joined the University of Colorado-Boulder's faculty in 1985 as an assistant professor and, later, full professor. Among her many awards and distinctions, Dr. Johnson received the Dennis Gabor Prize for creativity and innovation in modern optics (1993) and the John Fritz Medal (2008), widely considered the highest award in engineering. Dr. Johnson is a member of the National Academy of Engineering, the National Academy of Inventors, and the National Inventors Hall of Fame. She holds 118 U.S. and international patents and has five honorary degrees. | {
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Scottish Independence: Yes Voters and Salmond Constantly Misquote My Oil Figures says Sir Ian Wood
By Lianna Brinded
September 15, 2014 11:55 BST
Scotland\'s First Minister Alex Salmond poses for a selfie with a fan, as he stands with local pop stars during an event in Edinburgh, Scotland September 14, 2014 Reuters
Sir Ian Wood, one of Britain's most prominent oil and gas figures, has slammed the Scottish National Party and its leader Alex Salmond for repeatedly misquoting him on reserve estimates and therefore skewing the argument for independence.
Wood, who says the SNP's oil reserve claims are around 45% to 60% too high, said while he is not political, he felt he has to speak out, as the Yes campaign and Salmond had consistently misquoted figures from his independent review that was released earlier this year.
"I was drawn into this [discussion] because they were misquoting figures from my own review," said Wood in the Daily Mail.
"I am thoroughly Scottish, but also thoroughly British. This referendum vote is forever, there is no going back. This vote is not for this generation – I'm 72 for goodness sake.
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"It is for my children, for my grandchildren. I want them to live in a Scotland where youngsters have a chance of a good job and of being prosperous. The best chance they have of that is as part of a strong United Kingdom and get the best of both worlds."
Scottish people will vote in an independence referendum on 18 September, 2014, and will be asked the straight "yes/no" question: "Should Scotland be an independent country?"
The Scottish government claims there are 24 billion barrels of oil left in the North Sea while Wood stipulates that there are in fact only 15 billion to 16.5 billion barrels of recoverable oil left.
In keeping with the pro-independence campaign's oil production claims, N-56, which was founded by a member of the advisory board for Yes Scotland Dan Macdonald, North Sea revenues are pegged to be as high as £365bn (€456bn, $605bn) by 2041, if a series of recommendations were implemented.
However, the UK Office for Budget Responsibility (OBR) forecast is at £61.6bn between 2013/14 and 2040/41.
"Young voters must be aware that by the time they're in their 40s Scotland will have little offshore oil and gas production and this will severely hit our economy, jobs and public services," said Wood.
"The N-56 report is an insult to the Scottish people. That gets my back up, it's just pie in the sky. How can people make a critical decision on the basis of this kind of nonsense?' he says. 'It is a blatant attempt to manipulate voting sentiment."
Wood added that Salmond's claims that oil revenue would cover free prescriptions, university tuition and other issues, is wrong and that Scots should be wary of his claims.
"If you produce 200,000 barrels a day for the next 15 years, you will not have enough income. So how does the Scottish government then propose to fill this gap?" he added.
Related topics : Scottish Independence | {
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Q: Where to put forever logs on OpenShift Forever gives you the options:
-l LOGFILE Logs the forever output to LOGFILE
-o OUTFILE Logs stdout from child script to OUTFILE
-e ERRFILE Logs stderr from child script to ERRFILE
I want to have access to my logs for my application when I do rhc tail. Where do I tell forever to log my application if I want it to behave just as if I were running the process with node server.js?
A: I would direct them to the ~/nodejs/logs/node.log, that file gets picked up by rhc tail, and you should have write access to it.
| {
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Parafia Świętego Krzyża i Matki Bożej Nieustającej Pomocy w Tarnowie – parafia rzymskokatolicka znajdująca się w diecezji tarnowskiej w dekanacie Tarnów Północ w dzielnicy Krzyż.
Proboszczowie
ks. Jan Burgiel (styczeń 1925 – listopad 1925)
ks. Andrzej Juszczyk (1925–1930)
ks. Jan Curyło (1930–1931)
ks. Marcin Konicki (1931–1937)
ks. Marian Sułek (1937–1965)
ks. Andrzej Kmiecik (1965–1991)
ks. Władysław Kostrzewa (1991–1992)
ks. Zdzisław Puścizna (1992–2018)
ks. Jacek Olszak (od 2018)
Przypisy
Bibliografia
Informacje o parafii na stronie diecezji tarnowskiej
Krzyża
Parafie pod wezwaniem Świętego Krzyża
Parafie pod wezwaniem Matki Bożej Nieustającej Pomocy | {
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KELTAN® Eco 6950 by Arlanxeo is an amorphous, 70% bio-based, flexible, durable ethylene propylene diene rubber (EPDM) with medium mooney viscosity. Contains high ethylidene norbornene (ENB) content, very low ethylene content and non-staining stabilizer. Compatible with other synthetic rubbers. Exhibits reduced dependence on fossil resources and reduced carbon footprint (up to 85%), elasticity and heat stability. Offers excellent low temperature properties and ultra fast curing. Provides good weather resistance, great surface aesthetics, excellent electrical properties, good moldability and mixability. Designed for extrusion applications to produce greener products. Recommended for automotive sponge applications, dense profiles and wiper blades. KELTAN® Eco 6950 has a shelf life of 36 months. | {
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One Man; Over 1300 Public Buildings: James Barnet
Written by jml297
Scottish born James Barnet was the Colonial Architect of New South Wales from 1862 to 1890. Under his guidance, the architectural and civic landscape of the state changed and developed a confidence and character that is still evident today. These were boom years for the colony with the upgrade and replacement of early infrastructure as well as new buildings to meet the demands of a growing population.
Goulburn Court House
The length of tenure contributed to the sheer volume of buildings that were designed and constructed during these years. Many public buildings remain with alterations and in some instances perform a different purpose to their initial intention. But there is a style to these buildings which, once recognised, can be found in various city suburbs as well as many towns in regional parts of the state.
Bathurst Court House
Barnet was a classical, revivalist architect. Born in Scotland, he trained as a builder and stonemason before attending night school in London in order to attain his qualifications as an architect. Encouraged by a mentor, Barnet decided to migrate to one of the colonial outposts as there was an oversupply of architects in England at the time. In 1854 he migrated to Sydney with his wife, Amy.
Lithgow Court House
Similar to Scottish bridge-builder Lennox decades before, Barnet's potential was recognised whilst he was working on a building site as a stonemason. After a series of commissions he joined the Colonial Architect's Office in 1860. Two years later he was acting in the position of Colonial Architect, a position he held until 1890.
Katoomba Court House
The scope of work was wide and the quantity of buildings constructed was considerable. This included 169 post offices, 130 court houses, 110 goals and lockups, 155 police stations, 20 lighthouses, an extension to the Australian Museum, the Colonial Secretary's Office and the Lands Department building. These examples provide an insight into what was of importance at the time: communication, justice, transport and administration. Military defence and naval infrastructure were included in Barnet's remit, along with the maintenance of other public buildings.
Dubbo Court House
Barnet also designed the psychiatric hospital at Callan Park which opened in 1883 as the Hospital for the Insane. It consisted of 20 neoclassical buildings for the care of over 600 patients, male and female. The design was influenced by theories of the time which recommended high ceilings in a park like atmosphere.
Callan Park building
One of Barnet's most extravagant buildings was short-lived: the Sydney International Exhibition Building. Located adjacent to the Sydney Botanical Gardens on 5 acres, it was constructed in the spirit of the international exhibitions of the northern hemisphere and when complete was the largest exhibition space in the southern hemisphere – Melbourne was also striving for this title. The first electric light in Sydney was used to speed the building's completion as work continued around the clock. Over a million people came to the 'Garden Palace' to see the exhibition, quite amazing as the population at the time was just over two million. The building cost over three times its initial estimate and unfortunately was destroyed in a huge fire. Only a set of gates remain, located in Macquarie Street opposite History House.
Goulburn Post Office
Over his long career, Barnet served 16 ministers and oversaw the construction of over a thousand buildings. Despite similarities between buildings, templates as such were not used. Local materials and resources were used where possible. There were various parliamentary enquiries during his career and when he was finally forced to resign it was an ignominious professional end. Barnet was the last Colonial Architect as the office was restructured following his departure.
Many of his buildings remain today and as I travel about I like to keep an eye out for Barnet's touch in public buildings as I go.
Inspired by an excellent talk given by Emeritus Professor Don Napper.
Australian Dictionary of Biography entry on James Johnstone Barnet.
There is an extensive post about the prolific buildings designed by Barnet, particularly across the central west of NSW here.
[Photo: detail from Dubbo Court House]
March 27, 2017 March 26, 2017 · Posted in Mountain life · Tagged architect, Barnet, Callan Park, colonial history, Garden Palace, rural NSW, Sydney ·
8 thoughts on "One Man; Over 1300 Public Buildings: James Barnet"
such history and beautiful architecture…
jml297 says:
Thank you. I found the buildings in Goulburn by chance last week and was rather enchanted by both the courthouse and post office. They were buildings designed to make an impression. Thanks for your feedback 😊
I love architecture and these buildings are some of my favourites now that you have introduced me to them. Great photo's. Thank you.
I'm glad you liked them. For me, architecture is like art – I know what I like without really being able to articulate why it appeals to me. Perhaps with Barnet it is the familiarity of his work as there are buildings in many of the country towns and suburbs I have been through. I'm glad you enjoyed the photos too 😊
Gail Kaufman says:
These majestic buildings are impressive!
Thank you, Gail. Many of them are located in regional areas and small towns, which make them all the more surprising when you come across them.
Pingback: A Visit to Newcastle, NSW – jml297
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Spinning Yarns: Creative Collaboration » | {
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Southern Ports Authority, Port of Esperance On the 1 st October 2014, the Esperance Ports Sea and Land merged with the Bunbury and Albany Port Authorities to form the Southern Ports Authority. The Esperance Ports Sea and Land is now known as the Southern Ports Authority, Port of Esperance. u The Southern Port Authority trading as SPA is a statutory authority created under the Ports Legislation Amendment Act 2013 and is subject to the Port Authorities Act 1999 (amended) and Port Authorities Regulations 2001. The SPA operates as a Government Trading Enterprise and has control of the Port of Esperance. u The Port's primary role is to facilitate trade, to support the industry in this function, operate in a safe and efficient manner and return a dividend to the Government of Western Australia. u The Port consists of three operational berths Berth 1 is a land backed berth used exclusively for exporting grain products. The Port is currently looking at constructing an additional pipeline at Berth 1 to allow for the discharge of fuel. Berth 2 is a multi-user land backed berth importing sulphur and fertiliser in bulk form and fuel. Exports from berth 2 include mineral concentrates in containers and in the near future, woodchips. Berth 3 is an isolated marine structure known as a dolphin style berth and is dedicated to exporting iron ore sourced from the Goldfields region.
Buy Local Policy u The Port of Esperance has an internal Buy Local Policy which aims at supporting business through procurement of a variety of goods and services. u Why Buy Local? The Port of Esperance believes in supporting the township of Esperance and the region as a whole u Procuring locally & within the district ensures continuity of service and the economic benefit to the region.
Goods & Services Sourced by the Port The Port of Esperance source a variety Personnel, Goods and Services which include: Ø Ø Ø Ø Manufacturing & Engineering Services Industrial Cleaning & Sweeping Services Machinery & Equipment Hire Information Technology Specialists Corporate and Administration Services Rail Contractors Mobile Plant Maintenance & Subcontractor Services Marine Maintenance Providers External Training Providers Accommodation Services Providers Trades including Plumbers, Electricians, Carpenters and Builders Finance and Insurance Providers Local Retail and Wholesale Business' Professional and Technical services.
Regional Benefits The Port of Esperance provides an opportunity for the mining and agriculture sector to also contribute to the local economy through the facilitation of their trade.
Upcoming Port Projects Among numerous projects being developed at the Port of Esperance, a number of major projects have been identified and approved within the Port's capital budget: Ø Ø Ø Hughes Road Upgrade – $5 - $11 M Iron Ore Shed Ventilation Upgrade Construction of a Container Hardstand Area Berth 1 Pipeline Project – up to $1 M Heavy Haulage Transport Services Front End Loader Contractor *Projects will be subject to a tender procurement process.
Multi User Iron Ore Facility Ø In May 2014, the Yilgarn Esperance Solutions (YES) consortium was named as the preferred proponent to design, build and operate the new Multi User Iron Ore Facility valued at $200 M. Ø The consortium will finalise the design in conjunction with SPA prior to reaching financial close that is due within 18 months of contractual close. Ø Works will be tendered primarily by the YES consortium.
Looking into the Future u The Port of Esperance continues to grow in trade and over the next few years and is expected to double the amount of iron ore currently being exported via berth 3 to a very productive 20 million tonnes per annum. u The discovery and re-commissioning of mineral deposits may see the current mineral concentrate exports increase from 216, 000 tonnes per annum to potentially 400, 000 tonnes per annum. u In the second quarter of 2014, the Port of Esperance will see it's first ever trial of woodchip product exported using a mobile ship-loader across berth 2. u In 2013 -14 the Port handled two Post Panamax sized vessels. The CMB Medoc sailed with 78, 636 tonnes of grain and was the largest grain shipment to ever leave Western Australia. u In 2014 the Port completed maintenance dredging of the inner harbour and channel, removing 68, 000 cubic metres of sand restoring the Port to the original design depth and allowing vessels to load additional product. | {
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Seize the Day with the must haves for any writing aficionado are included in this deluxe Writing Set featuring a 5x7" lined Journal, Feather Quill Pen with Ink and additional Nibs, plus a Wood Handled Wax Seal with your own Initial and Sealing Wax. 2 Journal Styles available.
I bought this for my wedding invites ! Loved the wax and the stamp ! the Feathered pen will be used for the wedding guest sign in book. I am very happy with the purchase !
I thought this package was excellent. The only reason I am giving this order 4 out of 5 stars is because in my opinion the quality of the water-based ink was just below par. However for the price I'd say this is a great set and would highly recommend this set. Thanks!
The product is beautiful and I'm sure my boyfriend will love it when he opens it on valentines day. It was the exact set of what I was looking for, and for a very reasonable price compared to other websites. The shipping was also very fast! My one suggestion would be to make it more clear whereto indicate what letter the stamp should be. The email response to my inquiry also came very quickly! Great company, will purchase more.
i purchased this set for my girlfriend as a valentines day gift. needless to say she loved it. everything is top notch and well made. the ink is even a good ink for dip pens. my girlfriend was excited to see the "pointer finger" nib, which is now her favorite. my only suggestion is maybe some more customization for the kit, like different quills journals and wax. other than that, its an awesome kit. | {
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grandMA3
MA Network Switch
MA Dimming
Scancommander
Lightcommander
MA DMX Devices + Others
MA University
grandMA3 Basic Training
grandMA3 Transition Training
grandMA2 User Training
grandMA2 Advanced User Training
MA System Operator Training
MA System Specialist Training
dot2 User Training
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A tale of love and life
grandMA2 Rocks on Tony Award-winning "Hedwig and the Angry Inch"
© Joan Marcus
"Hedwig and the Angry Inch," the unconventional rock musical that recently captured four Tony Awards, may not be your grandma's Broadway show, but its use of grandMA2 lighting consoles keeps the edgy production on track at the Belasco Theatre.
"Hedwig and the Angry Inch" is John Cameron Mitchell and Stephen Trask's gender-bending musical tale of life, love and a botched operation. It won Tonys for its star, Neil Patrick Harris; co-star Lena Hall; and lighting designer Kevin Adams – Adams's fourth win. The play also received top honours as Best Musical Revival.
The lighting and video for "Hedwig" were programmed on two grandMA2 full-size consoles. During rehearsals Kevin Adams, video designer Ben Pearcy, associate lighting designer Paul Toben and second assistant lighting designer Jimmy Lawlor used grandMA onPC stations to monitor the production. Now, both lighting and video run nightly on a single grandMA2 light with an MA onPC command wing and an MA NPU (Network Processing Unit) as backup in the compact booth. Brian Dawson is the board operator.
"grandMA2 offered us a really good networking solution that enabled us to have multiple programmers on the system during rehearsals and give display feedback for the designers," says lighting programmer Benny Kirkham; Zach Peletz is the video programmer. "The show is very dynamic and we had to get it done quickly. Using grandMA2 and all its tools was the only choice to get the look we wanted."
Kirkham notes that the show "is supposed to depict a one-night-only concert by a punk rock group, so we had to create some of the insanity of that with the design. Kevin really walked the line well creating a show that's wild and anarchic without creating a distraction. The whole package comes together, and everything in the design works perfectly!"
Adams met Kirkham on the new Blue Man Group show at the Monte Carlo in Las Vegas where they worked on a grandMA2 console. They reunited for "Hedwig," and Adams was "delighted" to partner with the programmer and the grandMA2 again.
Adams liked grandMA2's graphical "Magic Sheets on the monitors," which meant he "never needed any paper" to speed up recalling control channel numbers. "I had a lot less info in front of me; I never needed any channel numbers. I could just point to the layout that Benny and I shared. It was very visual and intuitive. An entire layer of frustration went away."
Adams also liked the colour monitors. "With 'Hedwig' we have mostly moving lights. With the monitors in colour it was easier to understand what was happening live."
Kirkham notes that Adams "became quite a fan of the grandMA2" during the course of "Hedwig's" production. "It's fast and has the best effects engine on the market, which enabled us to create the look and feel we wanted," he says. "The grandMA2 was great at managing tracking and cue data – and there's no board that can fire up the popcorn machine as well as grandMA2 can!"
Kirkham says he's never been involved in a production as "collegial" as "Hedwig." "Every change moved the show to an even better place," he reports. "We're very proud of it."
"I've enjoyed working with Benny and the grandMA2 very much," Adams concludes.
PRG supplied the lighting equipment. A.C.T Lighting, Inc. is the exclusive distributor of MA products in the USA and Canada.
Used equipment:
2 x grandMA2 full-size
1 x grandMA2 light
1 x MA onPC command wing
1 x MA NPU (Network Processing Unit)
"It's an amazing system"
Phantom of the Opera debuts in Quebec with grandMA3
Phantom of the Opera has been an international phenomenon for more than 30 years. Now, the French concert version of the hit musical has debuted in Montreal and Quebec City where lighting designer...
Project of superlatives
MA Lighting for the Elbphilharmonie
In January 2017, the Hamburg Elbphilharmonie was ceremoniously opened featuring a stunning building design by the Swiss architects Herzog & de Meuron. This marked the beginning of a new chapter in the...
grandMA2 for Land of Kalevala
A celebration of Finnish history
Land of Kalevala is currently being staged at the Finnish National Opera, with set, projection and lighting designed by Mikki Kunttu.
The performance is about Finland in which the epic 19th century...
grandMA2 performs at Jiangsu Centre for the Performing Arts
Reliability and flexibility praised
The Jiangsu Centre for the Performing Arts, located at the Olympic Sports Center in Jiangsu Najing, is the largest modern theatre in China second in size only to the National Grand Theater located in...
La Traviata staged at Joburg Theatre with grandMA2
"It is easy, fast and never crashes"
Simon King is flying solo after working at the State Theatre in Pretoria for 28 years. He recently took a seat behind a grandMA2 full-size to light La Traviata, a stirring love story brought to The...
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The 2014 RMAC Golf Championship took place this past week in Goodyear, Arizona and the Orediggers finished eighth out of nine teams. After the first day of competition, the Orediggers were sitting in sixth place after two rounds of play, but in the final round of play on day two, Mines went +13 for the round to fall to eighth. The number seven team in the nation, Western New Mexico, lead from start to finish and captured the RMAC championship.
What drives plate tectonics? Heat flow, of course. Or energy transfer…it is all the same. It is the act of sketching poorly-drawn Mohr's circles that tires the mind and the hours upon hours scanning for the missing parenthesis that drains the eyes. Is there is even time to eat dinner? Lunch? Breakfast? Forget second breakfast and supper, right? But the physical laws of the universe remain: heat flows, dinner plates subduct, spread, or slip past each other from a lapse in friction, and fall onto the floor in a pile of entropic ceramic pieces.
In March, Rose Red Elk visited Mines to help campus celebrate Women's History Month.Rose Red Elk, also known as Red Feather Woman, came in traditional dress and shared songs and stories with the audience. She is a member of the Sioux/Assiniboine Tribes, hailing from the Fort Peck Reservation in northeast Montana. She described how she grew up listening to tribal folk stories but began her career in science and technology. While at Texas A&M, she started that college's first Native American science and engineering group. She had a promising career at IBM, but decided that her true calling was the arts. She has now been a professional singer and storyteller for over twenty years; she has put out four award-winning albums and is currently working on a comic book for the Department of the Interior.
Ilulissat, Greenland – A study led by Shfaqat Khan from the Technical University of Denmark has revealed that the Greenland Ice Sheet, the second largest body of ice in the world, is melting at a much faster rate than previously thought. A portion of the before unnoticed melting comes from the Northeastern Greenland, which was thought to be the last stable part of Greenland in terms of melting ice and glacial break-away. Because of warmer summers due to climate change, one of the glaciers in the South, Jakobshavn Isbrae, is retreating at four times the rate it had been in 1997.
On March 19th, the Schultz Family Leadership in Humanitarian Engineering Speaker Series kicked off with Dr. Michael L. Dougherty, from Illinois State University. Funded by the CEO of Dauntless Energy, the series will continue twice a semester for the next two years, highlighting social and corporate responsibility.
What Happened to the Ancient Martian Atmosphere?
On Tuesday, April 22nd, David Brain gave a lecture all about Mars. There has been much discussion about whether or not Mars had water on its surface and what happened to that water. David Brain works at the Laboratory for Atmospheric and Space Physics as well as the Department of Astrophysics and Atmospheric Science at CU Boulder. He has spent a lot of time studying the surface of Mars, and examining the differences between Mars and Earth that would cause such different environments, when the ancient Martian surface was likely similar to Earth's modern environment.
Penny Pettigrew has the coolest job in the world—she provides live support for astronauts living on the International Space Station. Pettigrew, who graduated from Colorado School of Mines with a BS in Chemistry in 1992, works for NASA in the Payload Operations Integration Center at the NASA Marshall Space Flight Center in Huntsville, Alabama. Though Pettigrew has never been to space herself, providing live support to astronauts on the ISS allows her to fulfill that childhood dream.
Following a federal appeals court ruling that struck down Federal Communications Commission (FCC) proposed rules to guarantee a free and open internet, the FCC has announced it will propose rules that would allow internet content providers to pay for special lanes to deliver content faster. Consumer advocacy groups are attacking the proposal on the basis that prices for service providers that can afford the fast lanes such as Disney or Netflix would probably be made to raise prices, while at the same time, smaller start-ups will be unable to afford the lanes which would stifle creativity and innovation online. | {
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All 70 Posts in the Category: Music
TV: The TV season is changing over. Of the shows I watched, Season 2 of Star Trek: Discovery wrapped up this week and The Orville has its season finale next week. Big Bang Theory would normally be ending around now, but it's the end of the series and they've scheduled their final one-hour episode in mid-May. And of course, Game of Thrones is back! As is another season of The Amazing Race.
+ GoT Season 8. From a little over 2 million viewers for its series premiere, to over 12 million for the Season 7 finale (at the time of airing), the world's most expensive TV show ($850m to make!) starts its final run. Apparently there is a 40 minute battle scene in an upcoming episode…
+ TAR is getting tired as a format, but my wife and I continue to watch it out of tradition.
+ Discovery flourished this season. As a die hard Trekkie, I found Season 1 really tough to digest given that it was meant to be canonical (why have we not heard about the mycelial network or Discovery or Spock's sister before?). But Season 2 papered over the cracks in the timeline enough to satisfy me. I also found the idea of bringing in some key characters only for a season interesting (like Anson Mount's Pike and Ethan Peck's Spock). Now it looks like the Discovery is 930 years in the future. I have been waiting for a new Trek franchise to be set further in the future for a couple decades now, so this is an exciting turn.
+ Trek seems to be getting a lot of spinoffs. There's Picard's new series, Georgiou's new Section 31 series, and now talk about a Pike spinoff. Oh, and there's Short Treks.
Music: This is the best cover of Dire Straits' Sultans of Swing like, ever.
9:53am • Music • TV • Tweet This • Add a comment •
What is this, I don't even (Korean edition)
Try looking away. You can't, can you?
This thing has over 32 million views.
10:49pm • Music • Tweet This • Add a comment •
Paul Simon at the Fillmore
Like the scent of a ex's perfume, some songs or artists trigger memories of certain past events in our lives. Paul Simon's music reminds me of a particular period in my life which came with a lot of mixed feelings. That added something extra to the performance, which was highly enjoyable. And interesting. Mr Simon is pushing 70 and the crowd at the Fillmore tonight was aged to match. The median age of the audience must have been in the 40s, but there were younger people there too – but it seemed that the older folk were getting stuck into the music a lot more. We were standing next to a man in his 40s and someone who appeared to be his father. The music had clearly triggered some memories for the father. Age had reduced his dancing to violent jerking and spasming, but he was clearly enjoying losing himself in the music (in between liberal drags of a few joints being passed among his family members). A friend said to me: "I don't think I've ever been to a concert where so few people have their phones in the air."
Paul Simon started pretty promptly at 8.30pm. The old man still has his voice and enough energy to put on a great 140 minute performance, mixing some old classic standards with songs from his new album and a couple of covers. Catch him while you still can – he's worth it.
1:04am • Music • Tweet This • Add a comment •
Three moving capos
Trace Bundy plays a song on his acoustic guitar with three moving capos:
See also this song, where he uses 5 capos. And here's a clip of him playing Pach's Canon with Korean wunderkind Sungha Jung.
New OK Go MV – timelapse & slomo
OkGO has another video out and this time they play with time. Very cool, as usual:
"The fastest we go is 172,800x, compressing 24 hours of real time into a blazing 1/2 second. The slowest is 1/32x speed, stretching a mere 1/2 second of real time into a whopping 16 seconds. This gives us a fastest to slowest ratio of 5.5 million. If you like averages, the average speed up factor of the band dancing is 270x. In total we shot 18 hours of the band dancing and 192 hours of LA skyline timelapse – over a million frames of video – and compressed it all down to 4 minutes and 30 seconds! Oh and don't forget, it's one continuous camera shot."
What passes for an "old classic" today
"I think that's the great thing about Glee. Old classics like this get rediscovered by teenagers."
– comment on Youtube, referring to Madonna's Vogue video.
"Old classics?" Ugh, I feel old. I was in primary school when that song came out and remember watching the music video on Video Hits. I was too young and thought it was a pretty weird clip. But now I think it's pretty cool.
OK Go – This Too Shall Pass (RGM version)
In one flawless take. Truly impressive. This is the RGM version. The original is here.
When karaoke turns homicidal
The NY Times has an article about how several people singing Sinatra's "My Way" have been killed in the karaoke bars of the Philippines. Not while singing any other song. Just while singing "My Way".
The killings have produced urban legends about the song and left Filipinos groping for answers. Are the killings the natural byproduct of the country's culture of violence, drinking and machismo? Or is there something inherently sinister in the song?
Whatever the reason, many karaoke bars have removed the song from their playbooks. And the country's many Sinatra lovers, like Mr. Gregorio here in this city in the southernmost Philippines, are practicing self-censorship out of perceived self-preservation.
The article also describes one creative method Filipinos have used to diffuse potentially lethal tensions in certain karaoke bars:
A subset of karaoke bars with G.R.O.'s — short for guest relations officers, a euphemism for female prostitutes — often employ gay men, who are seen as neutral, to defuse the undercurrent of tension among the male patrons. Since the gay men are not considered rivals for the women's attention — or rivals in singing, which karaoke machines score and rank — they can use humor to forestall macho face-offs among the patrons.
12:01am • Music • Tweet This • Add a comment •
Virtuoso pianist
Last year, 21 year old Nobuyuki Tsujii won the 2009 Van Cliburn International Piano Competition, tying with Haochen Zhang. The pieces he performed for the competition included Chopin's Twelve Etudes, Liszt's La Campanella, a couple of Beethoven's Sonatas, Liszt's Hungarian Rhapsody No. 2 (below) and Rachmaninoff's Piano Concerto No. 2.
Nobuyuki Tsujii was born blind.
Some Michael Jackson humour: CSI's take on it. Oh, Wikipedia…. This isn't funny, but its ironic.
11:21pm (GMT -7.00) • Music • Tweet This • Add a comment •
… suggestions for good music for a road trip.
3:42pm (GMT -8.00) • Music • Tweet This • Add a comment •
U2 at Telstra Stadium
Fantastic concert! Had to wait a year before they finally came, but I don't think anyone was disappointed! Set list for the night.
Crowd shot
Another crowd shot
"Coexist": I think this was put up around the time Sunday Bloody Sunday and Miss Sarajevo were played
Aussie flag sans Union Jack: U2 were probably playing to the right demographic for that political statement
Everyone waving their mobile phones in the air: doesn't come out very well in the pic, but the effect was cool
I thought it was a better show at Madison Square Garden in New York, but that was probably because it wasn't open air and was a more "intimate venue" where Bono could interact with the crowd a lot more (it ran longer, Bono chatted a bit more, guest appearance by Mary J Blige for One, a few audience members were dragged on stage to help sing, etc). But on the other hand, Telstra Stadium did have 75,000 people, and that creates quite an atmosphere.
8:02pm (GMT +10.00) • Music • Tweet This • Comments (4) •
Jaxter Artist Awards
The Jaxter Awards are now in their third year of running and there's more than $9000 worth of cash and prizes available. This year the competition has two sections: one for music composition and another for graphic design (of a CD cover). Know someone who's handy with an instrument or Photoshop? Get them to enter.
11:49am (GMT +10.00) tomorrow • Music • Tweet This • Add a comment •
What's that tune?
Can anyone tell me what the tune is on the Pepsi Max ad where a bunch of people jump in a dumpster, go tearing down the street, off a wharf and into Sydney harbour and go rafting? It sounds like it's from an old tv series, but I'm not sure what… And while we're on the topic of ads, that new Nike soccer ad is pretty cool, especially the bit where Ronaldinho gets taken out by the ref at the end.
10:28pm (GMT +10.00) • Music • Tweet This • Comments (3) •
Michael Bublé Concert
Went to see Michael Bublé's final Sydney concert with Denise and Jenny on Friday evening. When you fork out dosh to see a live performance, you're really there to see the performer perform – not just a repeat of what's out on their latest CD. Michael Bublé is great with the crowd and a surefire hit with the girls, at one stage jumping into the crowd to steal a kiss or ten from a particularly good looker in the front row. Her boyfriend took it in stride and ended up cuddling Michael. The girl, finding herself suddenly ousted from the action, leapt back in and threw her arms around the two of them, making it a threesome. (As Eddie Murphy said in his classic Delirious: "Being a comic though ain't like being no singer. The singers get all the pussy.")
More photos here
Most of the stuff was from his CD (including two of my favourites, That's All and The Way You Look Tonight), with some other great pieces thrown in. There were also a few short bursts of George Michael and Michael Jackson thrown in for laughs (no moonwalk, but he did sing Moondance). Good mix of slow and snappy songs. At the end he stepped away from the microphone and gave an acoustic rendition of a verse from My Funny Valentine. The hall slightly echoed his voice giving it a really rich, resonant quality. I don't know what it's called if it has a technical label, but like all good singers, he has the ability to finish off a line holding a sharp, crisp note that gently introduces a softly pulsating vibrato before gradually fading away cleanly. Terrific stuff.
Another view from a concert-goer at Kazzart.
1:10am (GMT +10.00) tomorrow • Music • Tweet This • Add a comment •
Soup Plus
I've known about Soup Plus for years, but I've never gone until last Tuesday. It's a place that plays jazz nightly from 7pm with a bar and restaurant. It's an aging, but cosy little venue down some stairs on George St near the old Strand arcade. We saw the jazz trio (drums, double bass, piano/vocals) of Brendan Clarke, John Harkins and Andrew Dickeson on the night. Excellent stuff. $5 cover charge on Monday to Thursday nights. The food is fairly affordable, and a great place to chill out if you like jazz. Especially if you've had a hard, longish day at work and don't feel like going home to cook.
Just bought tickets to see the last Michael Bublé concert at the Opera House. Should be good. I'd also pay to see James Darren but I don't think he'll be coming to Australia any time soon. He'd make a good convention guest for Holodiction, actually.
12:56pm (GMT +11.00) tomorrow • Music • Tweet This • Add a comment •
Michael Jackson, King of Pop and alleged child molester, may be about to have another horrible year ahead, but the moonwalk is still cool. Here are some instructions on how to replicate it. Sounds like you'd have to wear out several pairs of socks before you can perfect it haha.
12:01pm (GMT +11.00) tomorrow • Music • Tweet This • Comments (2) •
Finally! I got all ten volumes of Cafe Del Mar, plus the 20th anniversary set. Go BitTorrent! (Yes, I am still on 28.8k dialup. Yes, it did take a painfully long time.) Still need the chillhouse mixes and a couple other ones though.
My favourite is still Volume 7. Jose Padilla's stuff is the best. Bruno's selections (Vols 8, 9) are rubbish, although Volume 10 does manage to redeem him.
3:31pm (GMT +10.00) tomorrow • Music • Tweet This • Comments (2) •
Matchbox 20 Concert
MB20 was absolutely fantastic. After a couple of very tepid supporting bands, Rob Thomas and his crew came on stage and kept the crowd going wild for almost two hours. Just about all the band's hits were done, both new and old (I only noticed that "Girl Like That" was missing). The tempo was mixed, with the few traditional rock songs spaced out with slower piano pieces. "If You're Gone" was done unplugged, although it felt emptier, missing the brass that fills in the gaps in the album version. "Downfall" was also missing the gospel choir, but a choir would have been a bit troublesome to bring along with them! I was also hoping to hear "You and I and I" which they only seem to play live, but unfortunately no luck. Nonetheless, excellent stuff. Good to sing along with, good to move along with. If you like MB20, I highly recommend seeing and hearing them in concert.
Set List: Cold, Real World, All I Need, Soul, Disease, Could I Be You, 3 AM, Mad Season, Feel, Hand Me Down, If You're Gone, Bright Lights, Bent, (Cover), Unwell, Back to Good, You're So Real, Downfall, So Sad So Lonely, Long Day, Push.
Click above for more photos (600kb)
1:17am (GMT +10.00) tomorrow • Music • Tweet This • Comments (4) •
What Song?
Brownie points if anyone can track down the female artist/band that covered The Beatles' "All My Loving" – the version played at the end of 2-DAY FM's Hot 30 show (with Kyle and Jackie O) each night just before the greets and shoutouts. I haven't managed to turn up anything.
Digital Music Piracy
SMH Article: "The record industry says it is disturbed by a study showing more than half of young Australians are unaware that "burning" music CDs and swapping songs online is illegal."
For heaven's sake, if that is surprising to ARIA, the execs there are severely out of touch with society. Even for the older generation, having kids should be notice enough that music piracy is rampant. The same problems have plagued the computer software industry ever since its inception and we don't hear them complaining of their imminent collapse at the hands of the pirating hordes. It is incredible that ARIA is suddenly so worried.
Law is only effective if it is (1) known and (2) enforced. Music piracy, bar one current case, has never given rise to criminal prosecutions in Australia. As a result, piracy is widespread as there are no repercussions. Even if we also assume that people are genuinely unaware that it is illegal (come on, everyone knows copying music is wrong, but it seems less wrong than theft of physical goods), enforcement is a good way of "publicising" the law, as ignorance of the law is no excuse for violating it. The fact is, digital piracy is easy, free, does not visibly deprive people of anything physical, and proceeds unhindered. Music CDs are the opposite. When CDs are stolen, it is more the theft of the actual physical good, rather than the intellectual property contained on the CD, that is thought of as the crime by the layperson – even though the intellectual property contained on the CD is responsible for the majority of the labelled price.
People have been saying this for years: The music industry needs to address the piracy issue differently. They try to publicise that piracy is illegal, but people don't listen because no one gets busted for piracy. They then try to publicise piracy's illegality by enforcing the law. The problem with this is that the customer base for music piracy is made up of a gigantic number of small consumers (many under 18). Picking on individual users is likely to cause resentment among the music community, and perhaps may increase the levels of piracy as a knee-jerk reaction. You're only going to be prosecuted if you get caught, and for 99% of us, getting caught by ARIA is unlikely.
Other models, such as Apple's iTunes service, where music can be purchased digitally online for micropayments, while not removing the prevalence of piracy, will certainly mitigate it. Piracy cannot be eradicated, the recording industry should accept that. There are always people who will steal if they can get away with it (and I know of no one without at least one illegal MP3 on their computer). Instead, they should be turning their attention to alternative ways to bring people back to paying for music, and that means addressing why people currently find buying their music unattractive.
I have no problem with the idea of music piracy being illegal. Intellectual property should be protected. I only take issue with how the problem is being addressed, though I don't deny that there is no easy or completely satisfactory solution to this.
3:19pm (GMT +10.00) tomorrow from Mac Bank • Music • Tweet This • Comments (3) •
The three students must have been trafficking a huge amount of MP3s to have been arrested over it… I don't know anyone who doesn't have an illegal MP3 (or hundred) on their computer.
Ad Music, Breaks and Beats
Ever wondered what songs or breaks a commercial was using? Here are two UK-based databases: AdvertSongs and Commercial Breaks and Beats. For example, that classic Peugeot ad with the Indian sculptor (full clip is here).
This summer the famous Enrique Iglesias had a concert in romania. It was all playback. But some of the sound guys recorded his real voice from microphone output: http://www.247365.com.au/extras/enrique.html.
I don't know if this is legit, but it sounds horrendous nonetheless. Thanks Pete!
2:19pm (GMT +10.00) tomorrow • Music • Tweet This • Add a comment •
Here's a whole repository of sheet music for Nobuo Uematsu's Final Fantasy compositions, for all types of instruments.
Jaxter Music Awards
A friend is running a national music composition competition. It's called the Jaxter Artist Awards. Entry fee is $25 for any original composition/song. You have to be under 35, but I don't think that's a problem given the demographics of this site's readership :). Spread the word to any of your musically talented friends.
KaZaA still hanging on, despite a court order to shut down.
This is an interesting article on the potential follies of record companies releasing CDs that are unplayable through computer CD drives.
3:13pm (GMT +11.00) tomorrow from Work, Burwood • Music • Tweet This • Add a comment •
This site is offering 100 free mp3 downloads. You have to provide credit card details, but you can cancel after you grab your music. (It's got Trek on the page, but I think they have more to download besides Trek music.)
RIAA vs KaZaA/Morpheus/Grokster
Napster's Dead (and they want to charge US$5 a month for it? Do those guys have a brain?), Morpheus may be soon to follow after a lawsuit was filed against it by the RIAA yesterday. Wired article.
Napster Alternative
Ok we all know Napster has crap all on it now. I haven't had time to try the 100 different alternatives floating around out there, but Morpheus does the job quite nicely. It's got the usual file resumption and segmented download features. More importantly, it reaches around a quarter million users trading 100 terabytes of files during peak time. Pretty reliable (for a dialup connection) and it finds most of the stuff I look for. Seems to be growing too. (Download)
7:00pm (GMT +10.00) • Music • Tweet This • Add a comment •
My friend Phil (of Tatterdemalion) has had another venture into music kicking off with four solid funky mixes of rock/techno. So, have a listen to Rebirth. Those tracks so remind me of the .mods they used for the old Star Control games.
The Hangover Cure
Can't remember the last time I went out and bought a music CD, but The Hangover Cure is a nice mix of songs. A few songs are a bit thumpy, but overall it's not a bad compilation.
a-Studyin'
It's nothing but me, a book full of obfuscated text lawyers call law, and the soothing strains of some Café Del Mar CDs to help me maintain my sanity. Ambient music at this hour is terrific.
I've just had the bludgiest Saturday afternoon. I decided to take the computer downstairs and hook it up to the home theatre amp downstairs. Also gave me the chance to try connecting the never-before-used SPDIF digital out of the SBLive to the coax in of the amp. Then I just laid back on the couch and listened to MP3s for the rest of the arvo. Relaxing :)
If you have the chance, try plugging your sound card into a hi-fi system (if you don't have a digital out/in, you'll need a 3.5mm stereo to dual RCA cable)… the difference between them and the comparatively pissy little computer speakers you're probably using is huge (computers don't normally have a 15″ sub).
11:00pm (GMT +10.00) • Music • Tweet This • Add a comment •
Great MP3 site (esp if you're a regular Triple J listener, which I'm not) but there's lots of good music there.
Napster Buycott
Seems to have flopped. (Via Tunney's blog). Incidentally I got an e-mail from him, which was unexpected and gratifying :). Unfortunately, I'm not a Triple J listener, so I've never actually heard him on radio.
Napster… Good!
A friend and I ordered Napster shirts from Offspring. We'll wear them if we have to do a presentation of our research paper (which will be on MP3s) for IT Law later in the semester :).
The radio is dead. My uncle is now supplying mp3 music in his surgery for his patients to listen to. Ok, so the radio isn't really dead, but I did find the fact that he switched over to playing stuff from his mp3 collection amusing.
This mp3 Shaf sent me is incredible. It's of some guy singing in Hindi. But what makes it incredible, is he sings for about 2.5 minutes straight on one breath (ie: he never refills his lungs for the entire duration of his singing). It's no coincidence the song is called Breathless. Amazing. I swear, it makes you breathless just listening to it.
From CNN
Swap MP3s, go to jail? Software piracy is a crime too, but we don't see that ending anytime soon, do we?
Wrapster
Apparently a Napster add-on that allows transfer of files other than MP3s. Does anyone know where to obtain it?
Essential Download
I've said before that Napster runs on several separate servers, right? Napigator allows you to poll Napster servers (ping, number of users online etc.) and connect to any of them. Very nice.
There's now a Beta 5a version out.
Napster Tip
There isn't just one Napster server. There are several which are at present unlinked to each other. The master server transparently forwards you to the "optimal one". So, if you can't find a song on the server you're currently on, disconnect and reconnect and most likely the master server will assign you to a different one, with different people.
Beta 4 just came out. Looks nicer. Grab now and perpetuate copyright infringement on the net :).
MP3 Organiser
Looking for a powerful program to catalog your MP3 collection? Try Shuffleplay. It has a feature called a "recursive search" that will find all your mp3s on your computer, on all harddrives. It also will do a batch renaming of files and ID3 tags. Very nice. And there's always this place, if you want to crack it.
Schmick MP3s
Booya! has been pimping some schmick MP3s lately.
MP3 sites
Courtesy of Lonestar, which is further courtesy of Bence. Hear Ye! has no compunctions about linking mp3 sites ever since the swede teenager was acquitted :). Link here.
Plugged on Geeklife and Shazbot already, Napster is too good to be true. But it's true, and it deserves another plug. Find bloody well any mp3 in 5 minutes. Haha I was taking requests for songs over icq with this and making everyone wonder how I could find songs so quickly :)
Useful Spam?
Strangely enough, this link is brought to you by spam (weird spam – it had a CC list). DJ008 is an MP3 site which offers DJ mixes. Some good stuff there.
Got bandwidth to burn while you sleep? :) Couple of "top 40" type mp3 sites – here (mp3 hitzone), here (mp3 direct download) and here (music lover).
Hey. Mr Tambourine. Man.
Despite William Shatner's wife dying, I'll make this post. Apparently back in the 60s Shatner released an album, but since he couldn't actually sing, he spoke the words in a dramatic sounding voice. Listen especially to Lucy in the Sky with Diamonds and Mr Tambourine Man. Very much a case of don't skip your day job. And there's also a link to a related album on CDNow. Spock, also has an album. Thanks to Phil.
Yo yo yo yo Yoda
To the tune of Lola. Hear this (Yoda, not Lola) in MP3 – 3.2MB. Very catchy :)
I met him in a swamp down in Dagobah
where it bubbles all the time like a giant carbonated soda
S-O-D-A soda
I saw the little runt sitting there on a log,
I asked him his name and in a raspy voice he said Yoda
Y-O-D-A yoda yo-yo-yo yo yoda
Well I've been around but I ain't never seen
a guy who looks like a muppet but he's wrinkled and green
oh my yoda
Well I'm not dumb but I can't understand
how he can lift me in the air just by raising his hand
oh my yoda yo yo yo yo yoda
yo yo yo yoda
Well I left home just a week before
and I've never ever been a jedi before
but Obi-Wan he set me straight of course,
he said yoda yoda and I'll show you the force
Well I'm not the kind that would argue with Ben
so it looks like I'm gonna start all over again
with my
yoda, yo yo yo yo yoda
so I used the force,
I picked up a box
I lifted some rocks
while I stood on my head
Well I won't foget what Yoda said
He said Luke stay away from the darker side
and if you start to go astray
let the force be your guide
oh my yoda yo yo yo yoda
I know Darth Vader's really got you annoyed
but remember if you kill him then you'll be unemployed
oh my yoda, yo yo yo yo yoda
Well I heard my friends really got in a mess,
so I'm gonna have to leave Yoda I guess
But I know that I'll be coming back someday
I'll be playin' this part 'till I'm old and grey
The long term contract I had to sign
said I'd be making these movies 'till the end of time
(repeat 'till end of song)
CDNow CDs
Hey… my Star Wars CDs from CDNow arrived… the double CD sets for each of the trilogy movies costed about $18 US, whereas they cost $50 in Australian stores. CDs are too damn expensive here.
Lyrics.ch
Hey! www.lyrics.ch is back up! Sort of… no lyrics… just album listings.
The Phantom Menace Soundtrack in MP3s!
Go and grab them before they get yanked off the net!
Sunscreen Song
forgo Daily posted a copy of The Sunscreen Song on his site (MP3, 16kBps degraded quality, however). So now you can get both The Sunscreen Song (Quindon Tarver version) and Not The Sunscreen Song (John Safran version). Although if you're not Australian, you probably won't get a few of the things said in Not The Sunscreen Song ("Forget Adelaide… it's a hole."). I can't remember if the Safran version is zipped, or merely renamed. So if you can't seem to unzip it, just rename it to have an mp3 extension.
UPDATE: I found a full quality MP3 of The Sunscreen Song (aka Everybody's Free (to Wear Sunscreen)). 6 Megs or so, but it's definitely worth it :).
Not the Sunscreen Song MP3
I uploaded it and it's available at this address (~5 MB). Enjoy. You'll need to unzip it first (as opposed to merely renaming it). If you don't know what this song is, it's a spoof on Quindon Tarver's "Sunscreen Song" (which is not really a song, just some guy giving advice on living life). This spoof is a cack.
Yes I do have this Mp3 (lotsa search engine referrals regarding this). I don't have space to put it up on the web, so just buzz me on ICQ (766185) while I'm online if you want a copy. Or, even better, does someone have any space where I can store a 4 Meg MP3?
I know you're looking for them :) Here's a listing of the US Top 10 + download links. American Top 10 MP3.
Remember Milli Vanilli?
They're still infamous :). Click Here for a small diversion.
Plagarised from KillKrazy
Directly from Watch the World Die (other great stuff there :), is the answer to the question I asked on 18/12.
ask killkrazy
Inferno lobbed this question on his website…what's the difference between the music genres rock, alternative rock, and alternative? Instead of emailing him what I thought, I'll answer it here instead.
First off, alternative rock and alternative are one and the same thing, so the question really is, "What's the difference between rock and alternative?" Nowadays, and this is gonna sound repetitive, there is no difference. Alternative died when Nirvana hit it big (and was buried when Nine Inch Nails also hit the charts) and record companies realized that the buying public was sick and damn tired of Madonna, Michael Jackson, Def Leppard, and Bon Jovi (and all their clones).
So, what the hell was alternative? Well, the genre can only be defined by the bands that were considered alternative. Janes Addiction and the Pixies spring to mind. So does The Smiths, Red Hot Chili Peppers and Skinny Puppy (before their music was classified as Industrial – this may be my own personal interpretation). Love and Rockets (and the previous incarnation of the band Bauhaus – although, as is the case of the Smiths and The Cure, these bands are retroactively called Goth Bands).
Basically, alternative was advanced garage bands that were too skilled to be ignored and two weird to gain "mainstream" attention – thus, they were "alternative" to mainstream tastes (as defined by record companies). That's the best I can do for an official definition of the term.
But, like I said, alternative is dead. The music scene is one big melting pot of Marilyn Manson, The Prodigy, and Puff Daddy and his extended family. Ten years ago, these bands and others like them would be basically unknown with a hardcore following. Times have changed, thank all that's holy, and now more exposure is given to bands and artists that don't just sing shitty little love songs. Nowadays, the closest anyone comes to being alternative is, maybe, Ani DiFranco or Bif Naked. Maybe Rammstein and Atari Teenage Riot can be thrown in there, too. It's a hard call, and not one I'd like to make to be perfectly honest.
Regardless…it's all rock 'n' roll, which is even easier to define…it's whatever music your parents hate.
Thanks! There's your answer Yappy. So… it appears all the genres have blended somewhat.
Can someone point out the differences between the genres – rock, alternate rock, and alternate?
Here's a song that's being played to death on MIX 106.5. I heard From this Moment On (Shania Twain) played 4 times in a 24-hour period, and 3 times in another 24-hour period within the last fortnight. I wasn't even listening 24-hours – it just happened that every time we were in the car, that song was being played. As a sidenote, I *think* I heard somewhere that she was going to sing this at the Nobel Peace Prize… huh?
Help! I swear I'm hearing this damn song everywhere – radio, shops, malls – and at least once a day. Stop it!
Old news, but it has to be said… One down, "only" four to go…
There's something about Aqua's music that makes it fun to listen to. I know that it sounds stupid or annoying or whatever etc. etc., but I find their music enjoyable. As the band says about their own music: "it's so … it's so … corny". So it is intentional. Secondly, they're Danish, and they have strong foreign accents, but when they sing, that accent disappears. It's the same with any other foreign based bands/singers (Celine Dion, The Corrs etc.) … they all seem to revert to an American accent when singing. How do they do that?
Hosers. All o' them. And their music isn't too much better either. This letter to the SMH (2/3/98) says it all :
Lords of the Skies
If I, as an average citizen, became drunk and annoyed and harassed others on an aeroplane I would be restrained and then placed into the hands of police with charges ranging up to and relating to "Safety of Aircraft".
But if I was a sportsman or a pop group…
C. J. Macpherson,
Tamworth.
Haha, Tandberg's drawn a cartoon above the letter with one of the Oasis guys, guitar in hand, yelling at a couple of extremely irate passengers : "IT'S COMMON COURTESY TO REQUEST AN F'N ENCORE!".
Visit www.dimensionmusic.com for mp3 news – the site for MP3 related material (though I do have a sentimental attachment to the Aussie-run Outer Limits, which is unfortunately still offline). I'll do a write up on what MP3s are later. See Dimension Music anyway, though. It's one of the sites I visit on my "daily site runs" :).
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Outdoor / Skate / The story of two young Cuban skaters with one shared dream
The story of two young Cuban skaters with one shared dream
Skating, for which you need so little, can sometimes cost a lot
Posted Thursday 24th March 2016 /
Text By Carlos Álvarez Rodríguez / Juan Cruz Rodriguez
Photography © Juan Cruz Rodriguez/YMGFILMS/Chris Miller
A story of two skaters, with one shared dream
To be a skater in Cuba requires imagination - trade embargoes mean boards and materials are scarce. This is the story of two skaters, Yojani and Raciel, who shared the same dream of making it big.
In Havana, Cuba, there are three obstacles that the sport and culture of skateboarding has had to scale: indifference, disinterest and mockery.
Skaters, a dispersed yet determined group of youngsters, have managed to find their place and recognise each other like only members of a tribe are able to. They've inked a tattoo on the city's copper skin, which has diversified it, even though no one noticed it was missing.
Havana, with it old habits, is a city that has gradually and begrudgingly opened its arms to skaters. Today, in 2016, the skate community has developed a strong enough sense of self to spread throughout the country.
Meaningful things always begin with the ridiculous. According to Alexander González Borrego, one of Havana's pioneering skaters, in the 80s, a handful of dedicated fanatics started taking the wheels off old school iron roller-skates, splitting them in two, and putting them underneath any old bits of board they could find.
Yojani
From the age of 10, Alexander started building his own skateboards with the help of one of his uncle, a carpenter. The first materials which went into making the boards came, like everything else (food, fuel, clothes), from the Soviet Union. By the mid-eighties, different types of boards could be seen on Havana's streets such as cruiser or aloha style boards and even some twin tails.
However, this was not the norm. The poorer skaters – who didn't have relatives living abroad – had to build their own boards from scratch and fix them when they broke. With the 90s' economic crisis, in a country lacking even the bare essentials, you could say that skaters were, above all, enthusiastic artists rather than real skaters. They were kids living in the heart of the developing world trying to imitate the cool tricks and urban culture of the American youth.
No accessories, no helmets, no knee or elbow pads, dishevelled clothes were mandatory. These kids were nothing but masters of imagination.
In the 90s, with the arrival of tourism, many visitors were surprised to discover the emerging skate scene in Cuba. People skated at the 23 y G Park in Vedado, in the Prado and Capitolito. Numbers started to grow and by 2004, Red Bull hosted – through INDER (the Cuban Institute of Sports) – a radical sports event. Cuban skaters, facing the indifference of national institutions (skating was still seen as an American sport for bums), managed to participate thanks to donations from foreign groups, amongst which Amigos Skate Cuba was the most important.
By 2006, the group of skaters from 23 y G, in Vedado, was firmly consolidated as the best in the city, and the popularity of skating was reaching its peak. Later on, a skate park was built outside the multipurpose hall Sala Polivalente Ramón Fonst, in Plaza, and shortly afterwards another one in the Eco Park between Avenue 51 and Boyeros.
Two of the most determined exponents of the sport, Yojani Pérez Rivera and Raciel Pereda Bernet, were close friends and shared similar dreams. Both wanted to leave the country, one wanted to open a skate and surf shop in California, and the other wanted to design skateboards.
Yojani and Raciel
Every afternoon, dozens of kids went skating with Yojani and Raciel leading the pack, like heads of the family. However, in Cuba, families don't last long. Our greatest art is disintegration.
Ten years later some things have changed for the better and others haven't changed enough. Groups of female skaters have emerged, for example, but we're still talking about a closed culture, which society interprets through stereotypes. At some point, Yojani had a daughter and settled down permanently in Cuba with his girlfriend, a tattoo artist, letting go of his American dream. "Now that skating is an Olympic sport, the government has shown a little bit more interest, but there's still no sponsorship", he says today.
His dream is no longer to leave Cuba, but instead to promote the sport in the country he calls home. With the new political climate, and the loosening of relations with the US, Yojani believes that the arrival of mass international tourism can spark interest and create investment in the development of Cuban skating.
Meanwhile, Raciel, after taking a raft across the Florida Strait that didn't reach the US, travelled half a continent from Ecuador to cross the American border in northern Mexico. He currently lives in Miami with his parents and works in a ceramics factory mixing paint. He wakes up very early every day, leaving him no time to skate, although he practises religiously every weekend. He hasn't given up the idea of opening a business based on his designs, but to achieve this he needs time and contacts. Skating, for which you need so little, can sometimes cost a lot.
Translation by Adriana Francisco and Moray Mckie.
Carlos Álvarez Rodríguez
cuba week
Juan Cruz Rodriguez
Posted Thursday 24th March, 2016
Art & Culture > Print > Zine Scene
Uncovering Italy's radical rollerblading scene
A post-mortem on Big Brother, one of skateboarding's most influential magazines
Dave Carnie and Sean Cliver in Paris
Video: Life as an illegal tattoo artist in Havana
One foot forward...
Outdoor > Skate
Video: Skating through a waterpark on lockdown
Quarter pipes on the water pipes | {
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"redpajama_set_name": "RedPajamaC4"
} |
In summary, our findings indicate that bFGF stimulates CPT1 expression, FA oxidation and lactate production with the participation of PPARβ/δ activation. On the other hand, this investigation shows that FSH concomitantly regulates the expression of genes involved in FA metabolism and in mitochondrial biogenesis in Sertoli Capecitabine independently of PPARβ/δ activation. Metabolic processes such as FA oxidation, mitochondrial biogenesis and lactate production in Sertoli cells are essential for the energetic metabolism of the seminiferous tubule. The fact that these processes are regulated by hormones in a different way reflects the multifarious regulation of molecular mechanisms involved in Sertoli cell function.
Funding This work was supported by Grants from the Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET) (PIP 2011/187) and from the Agencia Nacional de Promoción Científica y Tecnológica (PICT 2011/677) and (PICT 2012/666).
Introduction Drugs targeting tumor blood vessels are commonly used in cancer patients and they generally produce limited therapeutic benefits for survival improvement (Cao et al., 2011). One of the main hitches of low therapeutic efficacy is that cancer patients often develop resistance in response to antiangiogenic drug (AAD) treatment (Bergers and Hanahan, 2008, Cao and Langer, 2010, Cao et al., 2009, Casanovas et al., 2005, Chung et al., 2013, Crawford et al., 2009). Patients with cancers grown in organs adjacent to adipose tissues, including breast cancer, prostate cancer, pancreatic cancer, and hepatocellular carcinoma (HCC), show particularly low benefits from antiangiogenic therapy. These cancers located adjacent to adipose tissues often show intrinsic or acquired resistance to antiangiogenic therapy. For example, most patients with pancreatic ductal adenocarcinoma (PDAC) show intrinsic resistance and colorectal cancer (CRC) patients exhibit evasive resistance to bevacizumab (Van Cutsem et al., 2009). A puzzling observation in the field of antiangiogenic cancer therapy has been the inconsistency of drug effects in preclinical animal models and in cancer patients (Cao et al., 2011). While most AADs produce overwhelming anti-tumor effects in mouse models, the same drug often lacks anti-cancer effect in human patients. Among numerous possible reasons, the location of tumor implantation in animal models is often different from clinical situations. For example, subcutaneous implantation is a common location for studying animal tumors for the sake of convenience in monitoring tumor growth. However, human tumors rarely originate from a subcutaneous location. Tumor tissues often experience hypoxia owing to accelerated growth rates of malignant cells, accumulation of metabolic products, disorganization of tumor blood vessels, and high interstitial fluid pressures (Makino et al., 2001). In response to AAD treatment, tumor vascular density often decreases to an extremely low level, creating an elevated hypoxic environment (Rapisarda and Melillo, 2012). It is known that tumor hypoxia can exacerbate expression levels of growth factors and cytokines, which circumvent the drug targets and create possible resistance (Casanovas et al., 2005). Hypoxia may also change the composition of various cell types within the tumor microenvironment (TME), leading to alteration of cancer invasiveness and drug responses (Cao et al., 2009). Unlike most healthy cells, cancer cells exhibit distinctive features of uncontrolled cell proliferation (Hanahan and Weinberg, 2011). To cope with the unlimited growth, expansion, and dissemination, cancer cells must efficiently produce energy, even in poorly oxygenated and nutrient-scarce microenvironments (Beloribi-Djefaflia et al., 2016). Cancer cells show exacerbated glucose uptake and glycolysis-dependent metabolism (i.e., the Warburg effect; Warburg, 1956). In addition, malignant cells also rely on glutamine consumption to obtain carbon, amino-nitrogen for producing nucleotides, amino acids, and lipid biosynthesis. Recent studies show that highly proliferative cancer cells have lipogenic activity by uptake of exogenous lipids and activating endogenous lipid biosynthesis (Beloribi-Djefaflia et al., 2016). Utilization of exogenous free fatty acids (FFAs) for energy production through the fatty acid oxidation (FAO) metabolic pathway is prominent in non-glycolytic cancers such as prostate cancer and B cell lymphoma (Caro et al., 2012, Liu et al., 2010). Several lipogenic enzymes, including acetyl coenzyme A carboxylase and fatty acid synthase (FASN), are often increased in invasive tumors and their expression levels correlate with poor prognosis (Kuhajda, 2006). The FAO-limiting enzyme, CPT1 (A and C types), is often overexpressed in many human tumors (Reilly and Mak, 2012). It is known that adipose tissue and FFA significantly contribute to cancer cell survival, proliferation, and migration (Lazar et al., 2016, Nieman et al., 2011). Previously published work also showed that anti-VEGF treatment and tissue hypoxia increase lipid transport and storage through an HIF-1α-dependent mechanism in cancer cells (Bensaad et al., 2014).
Nevertheless two problems exist in BGCFC in practice The fir | {
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} |
Tag Archives: psychedelic rock
POND close out US tour at The Fonda Theatre with a colorful palette of sounds
The Aussie psych rock group POND made their way West and landed at the Fonda Theatre Sunday night, putting the cap on a brief US tour with a colorful palette of sounds. The band has a propensity for such things, as each release of theirs (particularly the latest two records Tasmania and The Weather) build […]
David Fisch |
Premiere: Triptides Achieve Spiritual Instant Gratification with "Nirvana Now," — Plans European and North American Tour
Triptides are here to whisk us away to paradise. Today marks the debut of the video for their brand new single "Nirvana Now," which you can watch exclusively on Grimy Goods just below. It features all kinds of live footage, which is a fitting advertisement for their next tour. The group, led by Glenn Brigman […]
Zoe Elaine |
Interview: Exploring Context for Imaad Wasif's Lost-Then-Found Record, Great Eastern Sun
Imaad Wasif often feels like he not of this world. His realm is not physical, though it is tangible. I had the opportunity to pose him some questions about his recent record, Great Eastern Sun, and his career in general to get a chance to understand him and the process behind his profoundly moving work. […]
Dengue Fever Bring Newly Expanded Cambodian Pop, Psych Rock Sound to The Regent Theater
Cambodian New Year isn't until next week but Dengue Fever was already celebrating at The Regent Theater in downtown Los Angeles this past Saturday. Founded by brothers Ethan and Zac Holtzman more than a decade ago, the band continues to rock forth with their fifth album, The Deepest Lake, and are currently touring in support […]
King Khan & The Shrines to play June date at the Echoplex
Montreal psychedelic rockers King Khan & The Shrines return to Los Angeles for a headlining show at the Echoplex on June 27. King Khan is well known for delivering a wild and raucous show and their Echoplex date will be one you won't want to miss. This is a separate project from his notorious King Khan […]
Stream Mystic Braves new song "Great Company"
Echo Park's Mystic Braves have released an infectious new diddy titled "Great Company." The songs comes from the band's forthcoming album, New Days of Yesterday. Much like the majority of Mystic Braves catalog "Great Company" is a hazy psychedelic pop number full of 60s swagger. With a much more polished sound that includes the exotic strums of […]
The Jesus and Mary Chain announce Los Angeles tour date at The Glass House
The Jesus and Mary Chain have announced a headlining show date at The Glass House on Thursday, August 13. Additionally, The Jesus and Mary Chain are slated to play a week after at FYF Fest. The past year, the band have been celebrating the 30th anniversary of their iconic album Psychocandy. As part of their Psychocandy tour, […]
Tame Impala unleash a rainbow of sounds at Fox Theater Pomona
It's Coachella week, and as part of Goldenvoice's massive roll-out of Coachella sideshows, Tame Impala came to the Fox Theater Pomona last night to showcase their latest music. The Aussie psych rockers debuted two new song last night. Both "'Cause I'm a Man" and "Let It Happen" were recently shared on Grimy Goods as Tame […]
Roky Erickson takes The Roxy on a psychedelic trip down memory lane
Being a fan of The 13th Floor Elevators and too young to have had the opportunity to see them live, I was more than excited to see Roky Erickson at The Roxy this past Friday. He played with his son's band, The Hounds of Baskerville. Roky's son, Jegar, with his theatrical and rock 'n' blues […]
Blonde Redhead enchant a small private crowd at secret West Hollywood performance
It was a small private show at the offices of Flood magazine. I got there a bit early, way before they started allowing people in and watched the sound check of Blonde Redhead. They were deciding what songs to play as they also figured out which lights should go where. It was nice to watch the […] | {
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We've all heard the phrase, "An apple a day will keep the doctor away", but most people probably just shrugged it off as a reason to eat fruit. Fruit is good for you and there's a reason that you want at least two full servings of healthy fruit in your life every day. Apples, however, seem to be among the most healthy fruits that there are. If you are looking to get into shape or merely get a grip on your diet and get healthy then you should keep on reading. Listed below are the top 9 reasons to make sure that you eat an apple everyday!
Apples offer masses of antioxidants.
You've probably heard the word 'antioxidants' a number of times as you peruse health and fitness oriented website. No, antioxidants are not something you can file in under 'buzzwords'. Instead, antioxidants are super important for keeping your body healthy and devoid of serious issues. Antioxidants attack free radicals in your body and help reduce the amount of damage that they can do. Free radicals attack your healthy cells and open up the door for potential diseases down the line such as cancer. In apples the powerful antioxidant you will be eating is called quercetin. Quercetin is one of the most powerful antioxidants around and you get it from eating apples in just about any form. Whether you want to cut up some apples for your breakfast shakes or you just need some easy breakfast ideas, make sure to have a bushel of apples on hand.
Apples can lead to healthier teeth.
Make no mistake, apples won't whiten your teeth all on their own but they can be a valuable part of your dental care routine. The reason that apples, and all other crunchy fruits and veggies, help your teeth is simple: the act of biting and chewing an apple will lead to the stimulation of your saliva glands. The production of saliva increases while you eat the apple and said saliva helps to clean your teeth, reduce tooth decay, and alleviate the presence of heightened levels of bacteria. Have an apple after a meal and you'll go a long way towards helping out your oral hygiene. Apples also help to keep your teeth scrubbed clean and free of any excess food debris that tends to build up between your teeth and gums. Not a bad benefit for something you probably had no idea happened when you ate your daily apple!
Apples are a delicious source of fiber.
Fiber is extremely important to have in your daily diet because it is what helps keep your digestive system on track and on schedule. Apples are a perfect source of fiber and they help to keep your digestive system regulated while helping to improve the overall health of your intestines. High fiber foods also have a habit of helping to make you feel more full for longer periods of time. So if you want the perfect in between meals snack then consider reaching for your favorite kind of apple. Inside of an individual apple you will get up to 5 grams of soluble fiber and this fiber goes straight to work inside of your body. Some research has shown that this soluble fiber helps to prevent hemorrhoids, diverticulitis, and even potentially some advanced forms of cancer. There's little reason to avoid getting the proper amount of fiber in your diet, especially when it is so easy to include an apple in your lunch or on the go.
Apples are a heart healthy food.
While you need every part of your body to be working at an adequate level, there is little more important than keeping your heart beating. Keeping your ticker in great shape takes a lot of work because there are so many reasons why you could run into heart related health issues. Apples are an awesome way to keep your heart healthy and your body happy. Eating apples every day can lead to a reduction in your cholesterol. Having a reduced cholesterol level is absolutely imperative if you want to manage the chance of potential heart disease, strokes, or heart attacks. Apples also act as combatants to the build up of plaque from within your arteries. Lowering the plaque build up also goes a long way toward preventing heart attacks. This is particularly important if you happen to be female because heart disease is one of the most common killers of women. If you want a long and healthy life you could do worse than reach for an apple during your lunch break.
Apples are great for losing weight.
We've already begun to touch on why apples are great for losing weight but we'll swing the focus more directly. It seems like we are always looking for a tighter waist and more defined abs but we can't get those things without really controlling our weight. In America obesity is a true epidemic and the key to slimming down may rest inside of your apple a day habits. Apples are filled with soluble fiber which directly leads to you feeling more 'full'. This feeling of fullness comes at the expense of a very minor amount of calories and can be key in reducing your need to keep on snacking. Along with your fiber related fullness apples are also loaded with polyphenols. Polyphenols don't get digested when they are eaten and instead stick around in order to help influence the growth of positive bacteria in your gut. This bacteria is associated directly with weight loss and overall body wellness. This good bacteria helps to fight off the bad bacteria in your gut while restoring balance and reducing several issues related to the stomach. Add an apple to your shake or your post lunch break in order to get the most out of these benefits as they'll immediately begin to fight off the bad stuff going on.
Apples keep your eyes healthy.
You don't have to be a health nut to realize that keeping your eyes clear and healthy is a good thing in the long run. You'll hear this phrase repeated over and over again but that never makes it any less true: antioxidants are great for your body. Long term scientific research has shown a direct correlation between antioxidant levels and the prevention of cataracts in elderly people. People who eat a rich diet filled with antioxidants, from apples and other sources, have been scientifically shown to have a 15% less likely chance to develop the blind instilling cataracts that trouble so many of our older generation. If you have eye problems already or are afraid of having them in the future then you shouldn't waste any more time: jump on board and start filling out your diet with antioxidant heavy foods. Take care of your eyes now so that you don't have to worry about them later. Trust us, it is easier to prevent a massive health problem than it is to try and fix one years down the line when it is actively harming your day to day life.
I think the low key goal in life for most people is to always feel healthy and have enough energy to get the things that they need done in life. Apples, as it turns out, are great additions to your diet if you want to feel full while also getting more energy. Studies have shown that eating apples before working out will increase the amount of oxygen that makes it to your lungs — resulting in a longer, easier, and more effective workout. We could all use more energy and adding an apple to your diet can help you get there. Many fitness folks are now advising their clients to drink an apple smoothie about a half hour before heading to the gym. The smoothie helps out and tastes great as well!
Apples help you breathe easier.
Your lungs need to operate at a solid capacity to keep you feeling both clear headed and healthy in the long run. As you grow older breathing won't stay as easy as it was when you were younger. Think about how scary that could be! For people who already have respiratory issues and fear the development of asthma, consider adding apples to your diet. Science shows that a daily apple will reduce the risk of respiratory illnesses like asthma. What could be better than being able to breathe easy?
Apples are well rounded foods.
We've detailed various ways that apples can help you out in the long term when it comes to your health, but let's break things down even simpler. Apples are loaded with vitamins and nutrients and they have no fat or salt in their chemical make up. A large apple will run you only 80 calories while giving you natural flavor in your meal so that you actually enjoy it. Eating an apple a day is a no brainer, get on with eating them! | {
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After using your MoviePass card to purchase your movie ticket, tap the camera button on the verification pop up.
Allow MoviePass to access your phone's camera (if prompted) by clicking "Allow" on the permission dialog box. If you don't choose "Allow" then you'll have to later permit access by going into your phone's settings to switch the camera toggle to the on position.
Take a picture of your ticket stub.
That's it! Your picture has been submitted and you have completed ticket verification. | {
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} |
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Create awesome times over good food and with great company. COPPER FIRE in Belleville, IL offers mouthwatering dishes that will surely satisfy your palate. We also provide various catering options for special occasions. Most of our menu items include meals from American cuisine and cover everything, from a casual lunch to an impressive dinner—and a few surprises in between.
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Treat yourself to our delicious dishes that are guaranteed to have you licking your plate clean. Whether you're a professional who wants to take your team members out for dinner or looking for a place to catch up with friends, our restaurant should be on top of your list.
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Creating the ultimate dining experience is not only about food and drinks. The ambiance of the place also matters. At COPPER FIRE, you'll get to see live acoustic entertainment shows that will surely make your visit to our restaurant all the more enjoyable. | {
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from __future__ import unicode_literals
from django.db import migrations, models
import django.db.models.deletion
class Migration(migrations.Migration):
dependencies = [
('customers', '0001_initial'),
('products', '0002_product_image'),
]
operations = [
migrations.CreateModel(
name='Favorite',
fields=[
('id', models.AutoField(auto_created=True, primary_key=True, serialize=False, verbose_name='ID')),
('customer', models.ForeignKey(on_delete=django.db.models.deletion.CASCADE, to='customers.Customer')),
('product', models.ForeignKey(on_delete=django.db.models.deletion.CASCADE, to='products.Product')),
],
),
]
| {
"redpajama_set_name": "RedPajamaGithub"
} |
Does Jerusalem's Fall In 70 A.D. Matter To The U.S. Today?
When Jesus Christ looked out over Jerusalem, He wept (Luke 19:41). Why this outburst of emotion? It was not merely the realization that the city would soon be destroyed in a devastating war (vs. 43-44). It was concern over what the populace of that glittering metropolis was doing to itself to bring that devastation about.
Precisely, the same human nature, the same vicious attitude of mind, which was (and is) extant all over the world was then being unleashed in Jerusalem. And the people there could no more resist it than could any other people in any other city at any other time.
Outwardly the Jerusalem known by Jesus Christ had reached the pinnacle of grandeur, wealth and architectural achievement. But under the surface were vices only too familiar to the urban America of 2007.
"Stripped whole cities, ruined complete communities, and virtually announced to the entire country that everyone might be a bandit if he chose, so long as (Florus) himself received a rake-off" (The Jewish War, translated by G.A. Williamson, II. 14.).
In Jerusalem the people courageously sought to break the bonds of Roman oppression.And they quite understandably became desperate. Young hotheads grew restless. Rioting became a favorite pastime. In fact, unscrupulous government and civic leaders found it convenient to cover up their own crimes by inciting the mobs of the city to riot.
The favorite scene for mob confrontations and riots was Jerusalem's splendid Temple of God, where hundreds of thousands of worshippers congregated on religious festivals.It was, in fact, on these festivals -- Days of Unleavened Bread, Pentecost, Feast of Tabernacles--that civil strife reached its zenith (Wars, II. 1.3; II. 3.1). Violence finally became so common that armed guards were posted on permanent duty in the Temple during feasts "to forestall any rioting by the vast crowds" (ibid, II. 1.2.1).
Even so, political, religious and professional agitators, gang leaders and revolutionaries still did their part.Oftentimes, the frustrated passions of an oppressed people became vented in a tragically self-destructive manner. To modern-day Americans these mob scenes would have a familiar ring.
"But in the afternoon a number of men with revolutionary ideas collected, and began lamentations (complaints) of their own, piercing wails, weeping in chorus, and beating of breasts, that resounded throughout the whole city" (ibid., II . 1.2).
Just to test the government's sincerity, the mob began to make large demands: tax reduction, abolition of sales tax, and release of prisoners.In Short, the Jerusalem of the first century A.D. enjoyed all the fruits of an intricate multifaceted urban civilization with which we are becoming too painfully familiar in our own day.
There was violence, crime, and racial conflicts among Samaritans, Jews and Greeks, arson, looting of stores and burning of credit records, raiding of armories, gang warfare and political assassination.
Unscrupulous rulers blamed the riotous mobs in order to divert attention from their own crimes.
The revolutionary party in Jerusalem cast off all restraint. Every scoundrel surrounded by his own gang, stood out from his followers like a bandit chief or dictator and used his henchmen to rob respectable citizens (ibid, II. 14.1).
Of all the cities under Roman rule our own reached the highest summit of prosperity, and in turn fell into the lowest depths of misery, and for our misfortunes we have only ourselves to blame (ibid., pref., 4).
What occurred in Jerusalem more than 1900 years ago has a particular significance for today. Not for the Jerusalem of today, but rather for the urban areas of the United States and British Commonwealth. In a direct prophecy to these peoples, the prophet Ezekiel wrote: "The land if full of bloody crimes and the city is full of violence." (Ezk. 7:23).Especially American cities. But how many of us weep over America the way Jesus Christ wept over Jerusalem? Many of the prophecies of the Bible are dual.As Jerusalem fell in 70 A.D., so will America fall. Human nature never changes.We always follow the course of self destruction.The question is NOT IF we fall, but WHEN. | {
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Sake Dean Mahomed: The Man Who Brought Shampooing to Great Britain
by Akarsh Shekhar October 1, 2020 October 21, 2020
Shake Dean Mahomed (actual Urdu name: Sheikh Din Muhammad) was a famous Indian shampoo surgeon and restaurateur who holds the honour of being one of the first non-European immigrants who were embraced by the Western World. As it was common at that time, his actual Urdu name's spelling was modified to make it easier for Britishers to pronounce it so Sheikh Din Muhammad became Sake Dean Mahomed (alongwith numerous other iterations). This legendary Indian immigrant holds the honour of introducing Indian cuisine and shampoo baths to Europeans. He also holds the distinction of being the first Indian to publish a book in English. Let's find out more about this amazing individual.
Sake Dean Mahomed: All You Need to Know
When was Sake Dean Mahomed born?
Where did Sake Dean Mahomed grow up?
When did Sake Dean Mahomed leave India?
Who did Sake Dean Mahomed marry?
How many children did Sake Dean Mahomed have?
What is the name of Sake Dean Mahomed's book?
Who opened England's first Indian restaurant?
Who introduced shampooing to England?
Did Sake Dean Mahomed write books on shampooing?
When did Sake Dean Mahomed die?
What is Sake Dean Mahomed's legacy?
Sake Dean Mahomed was born on January 15th, 1749 in the ancient city of Patna. The current capital of the Indian state of Bihar was a part of British India's Bengal Presidency at that time. Sake Dean Mahomed's parents were Bengali muslims who were allegedly related to Bengal's Nawabs. Sake Dean Mahomed also claimed that he had ancestors who worked in administrative service under the Mughal Emperors. He belonged to the Maniharzada caste, and had studied alchemy and understood the methods used to produce various alkalis, soaps and shampoo.
Sake Dean Mahomed grew up in the city of Patna. Unfortunately, his father passed away while serving for the East India Company's Bengal army when Mahomed was just 11 years old. Captain Godfrey Evan Baker took Deam Mahomed under his wings after his father died. Dean Mahomed fought with the East India's Company army as a trainee surgeon during the company's conquest of the Marathas. Mahomed remained with Captain Baker until 1782, when the Captain resigned. That same year, Mahomed also resigned from the Army, choosing to accompany Baker, 'his best friend', to Ireland.
In 1784, Sake Dean Mahomed left India with the Baker family and emigrated to Cork, Ireland. There he studied to improve his English language skills at a local school.
While improving his English skills, Sake Dean Mahomed fell in love with Jane Daly, a "pretty Irish girl of respectable parentage". As it could be expected at that time, Jane Daly's family was strictly against the union and the couple was forced to elope and get married in 1786. Mahomed and Daly were married in the Diocese of Cork & Ross in Cork, Ireland. In order to marry Jane Daly, Sake Dean Mahomed had to leave his Islamic faith and convert to Anglicanism. He had to specifically convert to Anglicanism since Protestants were legally prevented from marrying non-Protestants. They moved to 7 Little Ryder Street in London, England, at the turn of the 19th century."
According to leading scholars, and as indicated by parish records in London, Mahomed conducted a bigamous marriage in Marylebone in 1806 to Jane Jeffreys (1780-1850); the banns were read on 24 August for Jane and "William Mahomet." He had a daughter, Amelia (b. 1808) with her and is listed as the father "William Dean Mahomet" in the parish register. Amelia was baptised on 11 June 1809 at St Marylebone, Westminster, in London. By his legal wife, Sake Dean Mahomed had seven children: Rosanna, Henry, Horatio, Frederick, Arthur, and Dean Mahomed (baptised in the Roman Catholic church of St. Finbarr's, Cork, in 1791)
His son, Frederick, was a proprietor of Turkish baths at Brighton and also ran a boxing and fencing academy near Brighton. His most famous grandson, Frederick Henry Horatio Akbar Mahomed (c. 1849–1884), became an internationally known physician and worked at Guy's Hospital in London. He made important contributions to the study of high blood pressure. Another of Sake Dean Mahomed's grandsons, Rev. James Kerriman Mahomed, was appointed as the vicar of Hove, Sussex, in the late 19th century.
Sake Dean Mahomed's book The Travels of Dean Mahomet
On 15 January 1794, Mahomed published his travel book, entitled The Travels of Dean Mahomet. The book is in epistolary form as was common for travel books and many novels in that era and consists of 38 letters. The book begins with a brief introduction where he contrasts Ireland and India, writing that "the face of every thing about me [is] so contrasted to those striking scenes in India" and proceeds to give a sketch of his early years. He then describes his travels over the period 1770 to 1775 as a camp follower to the Bengal army as it moved around North East India. A series of military conflicts are described along with descriptions of some major cities, including Kolkata (Calcutta) and Varanasi (Benares). This is accompanied by first hand accounts of Indian culture, trade, military conflicts, food, wildlife, etc. The book concludes with a description of Mahomed's voyage to Britain where he arrived at Dartmouth in September 1784. While Mahomed gives an insightful and sympathetic account of India and Indian customs, as Mona Narain points out this is done from an essentially European cultural perspective – he consistently uses the pronoun "we" to describe himself and Europeans, and does not in his writings seek to challenge poor governmental management within the East India Company. The historian Michael Fisher, who published a biographical essay to accompany an edition of the book, suggested that some passages in the book were closely paraphrased from other travel narratives written in the late 18th century.
Sake Dean Mahomed opened London's first ever Indian Restaurant, the Hindoostane Coffee House in George Street, near Portman Square, Central London. The restaurant's highlights were hookah "with real chilm tobacco, and authentic (or as authentic as they could be) Indian dishes. The curries made in Deam Mahomed's restaurant were considered unparalleled and unequalled by any curry ever made in England. The landmark restaurant had to close because of financial troubles but it heralded the start of a new era where "curry houses" have become as British as the pub these days.
Prior to his restaurant business in London, Dean Mahomed worked in London for nabob, Basil Cochrane, who had installed a steam bath for public use in his house in Portman Square and promoted its medical benefits.
Dean Mahomed is widely credited as the person who brought the tradition of Indian massage, or "champooing" to Great Britain. The term soon transformed into "shampooing". In 1814, Mahomed and his wife moved back to Brighton and opened the first commercial "shampooing" vapour masseur bath in England, on the site now occupied by the Queen's Hotel. A local paper described the treatment as "The Indian Medicated Vapour Bath (a type of Turkish bath), a cure to many diseases and giving full relief when everything fails; particularly Rheumatic and paralytic, gout, stiff joints, old sprains, lame legs, aches and pains in the joints".This business was an immediate success and Dean Mahomed became known as "Dr. Brighton". Hospitals also started sending patients to him and he even worked as the shampooing surgeon for the British Royalty.
The literary critic Muneeza Shamsie notes that Mahomed wrote two books connected to his burgeoning trade. The first was Cases Cured by Sake Deen Mahomed, Shampooing Surgeon, and Inventor of the Indian Medicated Vapour and Sea-Water Bath (1820), while the second, Shampooing; or, benefits resulting from the use of the Indian medicated vapour bath, went through three editions (1822, 1826, 1838) and was dedicated to King George IV. In this work, Mahomed speaks of the initial resistance to the idea of shampooing among the English he encountered in his new country: "It is not in the power of any individual to give unqualified satisfaction, or to attempt to establish a new opinion without the risk of incurring the ridicule, as well as censure, of some portion of mankind. So it was with me: in the face of indisputable evidence, I had to struggle with doubts and objections raised and circulated against my Bath, which, but for the repeated and numerous cures affected by it, would long since have shared the common fate of most innovations in science."
Sake Dean Mahomed's headstone in Brighton
Sake Dean Mahomed passed away on February 24th 1851 at 32 Grand Parade, Brighton. He had turned 92 a little over a month before his death. He was buried in a grave at St Nicholas Church, Brighton, in which his son Frederick was later interred. Frederick taught fencing, gymnastics and other activities in Brighton at a gymnasium he built on the town's Church Street.
By the Victorian period, Sake Dean Mahomed had begun to lose prominence as a public figure and until the scholarly interventions of the last fifty years was largely forgotten by history. The modern renewal of interest in his writings developed after poet and scholar Alamgir Hashmi drew attention to this author in the 1970s and 1980s. A book on Sheikh Dean Mahomed was written by Michael H. Fisher and it was titled "The First Indian Author in English: Dean Mahomed in India, Ireland, and England". The book was published by the Oxford University Press (OUP). Additionally, Rozina Visram's Ayahs, Lascars and Princes: The Story of Indians in Britain 1700–1947 (1998) was highly influential in drawing public attention to Mahomed's life and work.
Several commemorations of and tributes to Mahomed's legacy have taken place in the 21st century. On 29 September 2005 the City of Westminster unveiled a Green Plaque commemorating the opening of the Hindoostane Coffee House. The plaque is at 102 George Street, close to the original site of the coffee house at 34 George Street. On 15 January 2019.
Sake Dean Mahomed's plaque in Westminster
A man of many talents, Sake Dean Mahomed was an entrepreneur who made a name for himself by building cultural connections between India and England. On this day in 1794, he became the first Indian author to publish a book in English and later, to open an Indian restaurant in England—ushering in what would become one of Great Britain's most popular cuisines. Mahomed went on to find success as the "The Shampooing Surgeon of Brighton," opening a spa in the British seaside town that attracted the rich and royal.
In celebration of Sake Dean Mahomed's life, Google released a doodle on January 15th, 2019. This is what the Google Doodle Blog said:
"In 1810, after moving to London, Mahomed opened the Hindostanee Coffee House, Britain's first Indian restaurant. The Epicure's Almanack—an early London restaurant guide—hailed it as a place for nobility to enjoy hookah and Indian dishes of the highest perfection. Nonetheless, Mahomed was forced to close his luxurious restaurant in 1812 and sought to reinvent himself.
Moving his family to the beachside town of Brighton, he opened a spa named Mahomed's Baths offering luxurious herbal steam baths. His specialty was a combination of a steam bath and an Indian therapeutic massage—a treatment he named "shampooing" inspired by the Hindi word champissage meaning "a head massage." He also published a book about the therapeutic benefits of the treatment with testimonials from his patients. In 1822, King George IV appointed Mahomed as his personal 'shampooing surgeon', which greatly improved his business. A portrait of Mahomed hangs in the Brighton Museum, commemorating this man who helped merge the cultures of his two homelands.
Happy Birthday, Sake Dean Mahomed!"
Sheik Din Muhammad (Bengali: শেখ দীন মোহাম্মদ; 1749–1851) was an Indian explorer, specialist and business visionary who was one of the most striking early non-European outsiders toward the Western World. Due to his unfamiliar inception, his name is frequently spelled different routes in English documentation. He presented Indian food and cleanser showers to Europe, where he offered helpful massage. He was likewise the primary Indian to distribute a book in English.
"insofar as the Sepoy's keep up their arrangements, which they call 'lines,' they resemble a steady well of lava regurgitating ordnance and rifle discharge like persistent hail on the foe, and they are only from time to time vanquished."
Mahomet 1794
Conceived in c. May 1749 in the city of Patna then aspect of the Bengal Presidency in British India. He was from a Bengali Muslim family. He professed to be identified with the Nawabs of Bengal, and that he had progenitors who worked in managerial assistance under the Mughal Emperors. He had a place with the Maniharzada station , and had considered speculative chemistry and perceived the strategies used to create different soluble bases, cleansers and shampoo.
Purpose Dean Mahomed experienced childhood in Patna. His dad served in the East India Company's Bengal Army and kicked the bucket in fight when Mahomed was around eleven years old. Following his dad's passing, he was taken under the wing of Captain Godfrey Evan Baker, an Anglo-Irish Protestant official. Mahomed served in the multitude of the East India Company as a learner specialist and served against the Marathas. Mahomed stayed with Captain Baker until 1782, when the Captain surrendered. That very year, Mahomed additionally left the Army, deciding to go with Baker, 'his closest companion', to Ireland.
Grown-up life and Family
In 1784, Mahomed emigrated to Cork, Ireland, with the Baker family. There he concentrated to improve his English language aptitudes at a neighborhood school, and went gaga for Jane Daly, a "pretty Irish young lady of good parentage". The Daly family was against their relationship, so the couple ran off to another town to get hitched in 1786. Mahomed and Daly were hitched in the Diocese of Cork and Ross in Cork, Ireland. around then it was unlawful for Protestants to wed non-Protestants, so Mahomed changed over to Anglicanism to wed Jane Daly (1761-1844). They moved to 7 Little Ryder Street in London, England, at the turn of the nineteenth century."
As per driving researchers, and as demonstrated by ward records in London, Mahomed led a bigamous marriage in Marylebone in 1806 to Jane Jeffreys (1780-1850); the banns were perused on 24 August for Jane and "William Mahomet." He had a girl, Amelia (b. 1808) by her and is recorded as the dad "William Dean Mahomet" in the area register. Amelia was absolved on 11 June 1809 at St Marylebone, Westminster, in London.[16] By his lawful spouse, Sake Dean Mahomed had seven youngsters: Rosanna, Henry, Horatio, Frederick, Arthur,[8] and Dean Mahomed (sanctified through water in the Roman Catholic church of St. Finbarr's, Cork, in 1791).
His child, Frederick, was an owner of Turkish showers at Brighton and furthermore ran a boxing and fencing institute close to Brighton. His most well known grandson, Frederick Henry Horatio Akbar Mahomed (c. 1849–1884), turned into a globally known physician and worked at Guy's Hospital in London. He made significant commitments to the investigation of high blood pressure. Another of Sake Dean Mahomed's grandsons, Rev. James Kerriman Mahomed, was named as the vicar of Hove, Sussex, in the late nineteenth century.
The Travels of Dean Mahomet
On 15 January 1794, Mahomed distributed his travel guide, entitled The Travels of Dean Mahomet. The book is in epistolary structure as was regular for travel guides and numerous books in that period and comprises of 38 letters. The book starts with a concise presentation where he differentiates Ireland and India, composing that "the essence of every little thing about me so differentiated to those striking scenes in India." and continues to give a sketch of his initial years. He at that point portrays his movements over the period 1770 to 1775 as a camp devotee to the Bengal armed force as it moved around North East India. A progression of military clashes are depicted alongside portrayals of some significant urban communities, including Kolkata (Calcutta) and Varanasi (Benares). This is joined by direct records of Indian culture, exchange, military clashes, food, untamed life, etc. The book closes with a portrayal of Mahomed's journey to Britain where he showed up at Dartmouth in September 1784. While Mahomed gives a savvy and thoughtful record of India and Indian traditions, as Mona Narain calls attention to this is done from a basically European social viewpoint – he reliably utilizes the pronoun "we" to portray himself and Europeans, and doesn't in his compositions try to challenge poor legislative administration inside the East India Company. The history specialist Michael Fisher, who distributed an anecdotal article to go with a release of the book, recommended that a few sections in the book were firmly summarized from other travel accounts written in the late eighteenth century.
1794 Frontispiece of Dean Mahomet's Travels
Café adventure
Plaque recognizing Mahomed's café
In 1810, subsequent to moving to London, Sake Dean Mahomed opened the principal Indian eatery in England: the Hindoostane Coffee House in George Street, close to Portman Square, Central London. The café offered, among different things, hookah "with genuine chilm tobacco, and Indian dishes, … permitted by the best epicures to be unmatched to any curries ever constructed in England." This endeavor reached a conclusion because of budgetary difficulties.
Acquaintance of shampooing with Europe
Prior to opening his café, Mahomed had worked in London for nabob, Basil Cochrane, who had introduced a steam shower for public use in his home in Portman Square and advanced its health advantages. Mahomed may have been answerable for presenting the act of champooi or "shampooing" (or Indian back rub) there. In 1814, Mahomed and his significant other moved back to Brighton and opened the primary business "shampooing" fume masseur shower in England, on the site presently involved by the Queen's Hotel. He portrayed the treatment in a nearby paper as "The Indian Medicated Vapor Bath (sort of Turkish shower), a fix to numerous maladies and giving full alleviation when everything fizzles; especially Rheumatic and incapacitated, gout, firm joints, old injuries, faltering legs, a throbbing painfulness in the joints".[26] This business was a prompt achievement and Dean Mahomed got known as "Dr. Brighton". Emergency clinics alluded patients to him and he was delegated as shampooing specialist to both King George IV and William IV.
Mahomed's Baths, Brighton, 1826
The scholarly pundit Muneeza Shamsie noticed that Mahomed composed two books associated with his expanding trade. The originally was Cases Cured by Sake Deen Mahomed, Shampooing Surgeon, and Inventor of the Indian Medicated Vapor and Sea-Water Bath (1820), while the second, Shampooing; or, advantages coming about because of the utilization of the Indian cured fume shower, experienced three releases (1822, 1826, 1838) and was devoted to King George IV. In this work, Mahomed discusses the underlying protection from shampooing among the English he experienced in his new nation: "It isn't in the intensity of any person to give inadequate fulfillment, or to endeavor to build up another sentiment without the danger of causing the derision, just as blame, of some part of humankind. So it was with me: despite undeniable proof, I needed to battle with questions and complaints raised and flowed against my Bath, which, however for the rehashed and various fixes affected by it, would since a long time ago have shared the basic destiny of most advancements in science."
Mahomed was covered at St Nicholas' Church, Brighton.
Mahomed passed on 24 February 1851 (matured 91–92) at 32 Grand Parade, Brighton. He was covered in a grave at St Nicholas Church, Brighton, in which his child Frederick was later entombed. Frederick showed fencing, acrobatic and different exercises in Brighton at a recreation center he based on the town's Church Street.
By the Victorian time frame, Sake Dean Mahomed had started to lose noticeable quality as a well known person and until the academic intercessions of the most recent fifty years was generally overlooked by history. The advanced recharging of enthusiasm for his compositions created after artist and researcher Alamgir Hashmi caused to notice this creator during the 1970s and 1980s. Michael H. Fisher has composed a book on Sheik Dean Mahomet entitled The First Indian Author in English: Dean Mahomed in India, Ireland, and England (Oxford University Press, Delhi, 1996). Moreover, Rozina Visram's Ayahs, Lascars and Princes: The Story of Indians in Britain 1700–1947 (1998) was exceptionally compelling in causing public to notice Mahomed's life and work.
A few remembrances of and accolades for Mahomed's heritage have occurred in the 21st century. On 29 September 2005 the City of Westminster divulged a Green Plaque celebrating the kickoff of the Hindoostane Coffee House. The plaque is at 102 George Street, near the first site of the café at 34 George Street. On 15 January 2019, Google perceived Sake Dean Mahomed with a Google Doodle on the principle page.
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Akarsh Shekhar November 27, 2020 November 27, 2020 | {
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When Should you Have Your Mattresses Cleaned?
Cleaning a mattress (that is used daily) at least once a year is a great way to keep it in the best possible condition. Accidents such as spills, stains, odors, water damage may require immediate attention. We're here to make the process quick, easy and affordable.
It's surprising to know that many people aren't aware that a mattress can be professionally cleaned.
Mattress fabrics, as with most other fabrics, soil over time absorbing items from the surrounding environment along with a steady buildup of your biological 'left overs' such as dead skin.
Since most people spend about 1/3 of their life on a mattress, an annual cleaning is a very practical investment.
Your mattress can be completely cleaned and sanitized in less time it takes to wash and dry a load of laundry.
extend the usable life of your mattress.
A proper mattress cleaning must penetrate as deep as the stain and then be flushed and extracted out of your mattress properly to avoid mold, mildew and build-up.
Our Mattress Cleaning process will do the heavy lifting for you and have your mattress totally clean and sanitized.
Can a mattress really be cleaned?
Yes… any mattress that is used on a regular basis can and should be cleaned to eliminate and prevent buildup of contaminants including dead skin, allergens, stains, odors, etc.
For mattresses getting normal use, we recommend cleaning at least once a year. However, if you have pets sleeping with you or if you have allergies or asthma we recommend every 6 months to maintain a significantly lower level of irritants in your mattress.
In the event of accidents causing potential stains or odors we recommend a professional mattress cleaning as soon as possible.
Are toxic or dangerous chemicals used in your cleaning process?
Absolutely not! We use a mineral based non-toxic, allergy and asthma safe, soap-free anti-microbial cleaning solution that is EPA certified and meets all green certification standards.
How exactly will you clean my mattress(s)?
We utilize a 3-step mattress cleaning process: Step 1 – we thoroughly vacuum every surface of the mattress – top, sides and bottom. Step 2 – we apply a dry-foam anti-microbial cleaner and agitate by hand with natural sponges. Step 3 – we rinse with 210 degree water utilizing a special low-moisture upholstery cleaning system.
How long will it take my mattress to dry?
Because we use a low-moisture cleaning system, under normal conditions, it shouldn't take more than 2 hours for your mattress to be completely dry and ready to apply linens.
Can you remove the stains on my mattress?
We pretreat all spots and stains and most will be completely gone or significantly reduced.
Probably. There are mites in over 95% of mattresses and many with high enough concentrations to cause allergic reactions in people who never exhibited any previous allergic tendencies.
Should I really replace my mattress after 7 years?
This is what the mattress industry would like for you to believe. However, if you aren't experiencing sleep discomfort due to mattress structural issues we can save you a lot of money by cleaning and sanitizing your existing mattress. This will freshen your mattress by removing the buildup of dead skin, bacteria and odors and allow extended use of your mattress. | {
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Meghnad Saha: Indian Astrophysicist
Mr Singh
Meghnad Saha
Who Was Meghnad Saha?
Meghnad Saha was an Indian astrophysicist who is known for his contributions to the field of astrophysics. He is best known for developing the Saha equation, which is used to determine the physical conditions in stars.
Saha made many significant contributions to the field of astrophysics, and his work had a lasting impact on our understanding of the physical processes that occur in stars. In addition to the Saha equation, he also developed a theory of the ionization of gases, which is known as the Saha ionization equation. He also made important contributions to the understanding of the behavior of white dwarfs, which are the final stage of evolution for stars like the Sun.
Saha received many awards and honors for his scientific contributions, including the Padma Bhushan, the C.V. Raman Medal, and the Order of Merit.
Meghnad Saha was born in 1893 in the village of Dacca in East Bengal (now Bangladesh). He was the fourth of six children born to Jagannath Saha and Bhubanmohini Saha. His father was a wealthy landowner and his mother was a housewife.
Saha received his early education at the village school in Dacca and later attended the Brahmo Boys School in Calcutta. He excelled in his studies, particularly in mathematics and physics, and received a scholarship to study at the Presidency College in Calcutta.
Saha stayed at the Eden Hindu Hostel, which was provided to him by his university. Unfortunately, while he stayed there, he was the victim of caste discrimination because Saha belonged to the shudra caste; the lowest caste. The caste system made his life at university quite difficult.
After completing his Bachelor's degree in 1915, Saha joined the University of Calcutta as a research student. He received his Master's degree in 1917 and began teaching at the university as a professor of physics.
Saha was a brilliant scientist and was deeply interested in the study of astrophysics. He spent long hours in his laboratory, often working late into the night, and made many significant contributions to the field. In addition to his work as a professor, Saha also served as the director of the Indian Institute of Science in Bangalore and as the chairman of the Council of Scientific and Industrial Research in India.
Meghnad Saha on Right Hand Side
He is best known for developing the Thermal Ionisation Equation, which is used to determine the physical conditions in stars.
The Saha equation is a mathematical expression that describes the ionization of gases in stars. It is based on the principles of statistical mechanics and is used to determine the temperature, density, and ionization state of a star. The equation is an important tool for understanding the physical processes that occur in stars, and it has many applications in fields such as astrophysics, planetary science, and cosmology.
Saha received many awards and honours for his scientific contributions, including the Padma Bhushan, the C.V. Raman Medal, and the Order of Merit.
The Saha Equation
The Saha ionization equation was developed in the 1920s and is based on the principles of statistical mechanics. The equation is written as:
[Ionized atoms]/[Neutral atoms] = 2(2πmkT/h²)^(3/2) exp(-Ei/kT)
The left side of the equation represents the ratio of ionized atoms to neutral atoms in a gas, and the right side represents the probability of ionization. The equation is used to determine the ionization state of a gas, based on its temperature, density, and ionization energy.
The equation is an important tool for understanding the physical processes that occur in gases, and it has many applications in fields such as astrophysics, planetary science, and cosmology. It is used to study the behaviour of gases under different conditions and to predict the evolution of their physical properties over time.
Saha Equation
Saha's Publications
Saha published many papers and articles on a wide range of topics, including the structure and evolution of stars, the ionization of gases, and the behaviour of white dwarfs.
Some of Saha's notable publications include:
"The Ionization of Gases by Heat," which was published in the Proceedings of the Royal Society in 1920. This paper introduced the Saha ionization equation, which is used to determine the ionization state of gases.
"The Ionization of Gases by Heat. II," which was published in the Proceedings of the Royal Society in 1922. This paper further developed the Saha ionization equation and applied it to the study of the ionization of gases in stars.
"The Intensity of the Spectral Lines of the Hydrogen Spectrum and the Density of the Electron Gas in the Stars," which was published in the Astrophysical Journal in 1926. This paper introduced the Saha equation, which is used to determine the physical conditions in stars.
"The Structure and Evolution of Stars," which was published in the Annual Review of Astronomy and Astrophysics in 1949. This paper summarized Saha's work on the structure and evolution of stars and provided an overview of the current state of knowledge in the field.
"The Thermionic Emission of Electrons," which was published in the Proceedings of the Royal Society in 1952. This paper presented Saha's theory of the thermionic emission of electrons and its applications to the study of the behavior of white dwarfs.
Saha was also an avid reader and enjoyed reading books on a wide range of topics, including science, literature, and history. He was also an accomplished musician and enjoyed playing the sitar in his free time.
Saha was highly respected in the scientific community and was known for his integrity and dedication to his work. He received many awards and honors for his scientific contributions, including the Padma Bhushan, the C.V. Raman Medal, and the Order of Merit.
Meghnad Saha died on February 16, 1956, at the age of 62.
Sources and Further Reading
MN Saha: A scientist who cared | The Hindu BusinessLine
Meghnad Saha Biography | Facts, Childhood, Family Life & Achievements
Meghnad Saha was an eminent astrophysicist best known for his theory of thermal ionization. This biography of Meghnad Saha provides detailed information about his childhood, life, achievements, works and timeline.
Meghnad Saha: Physicist and nationalist: Physics Today: Vol 69, No 8
Deeply committed to the cause of Indian independence, Saha occasionally detoured from his physics to conduct a revolutionary mission or pen a populist manifesto.
Biography of Meghnad Saha(1893 – 1956 ) | Robolab Technologies Pvt. Ltd.
Meghnad Saha was a great Indian scientist. He made a remarkable contribution to the field of Astrophysics.
Meghnad N. Saha | Indian astrophysicist | Britannica
Meghnad N. Saha, (born Oct. 6, 1893, Seoratali, near Dacca, India—died Feb. 16, 1956, New Delhi), Indian astrophysicist noted for his development in 1920 of the thermal ionization equation.
© 2023 Mr Singh | {
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Early voting comes to an end in New York
by: NC 34 Staff
Posted: Nov 2, 2020 / 06:38 PM GMT-0500 / Updated: Nov 2, 2020 / 06:38 PM GMT-0500
BINGHAMTON, NY – Early voting came to an end across New York State yesterday with 15 percent of registered voters in Broome County casting their ballots ahead of Election Day.
After peaking at more than 33 hundred voters on Friday, more than 24 hundred people cast ballots each day this weekend.
In all, nearly 22 thousand Broome residents voted early.
County election officials say wait times diminished after last Wednesday when additional machines were deployed to each of the 4 early voting locations.
The Broome County Board of Elections plans to run the totals of early voting tomorrow evening at 9 once the Election day polls have closed.
Meanwhile, as of yesterday, almost 17 thousand absentee ballots had been returned out of more than 23 thousand that were mailed out.
Ballots that are postmarked by tomorrow will still be counted.
The opening and counting of absentee ballots will begin on Thursday November 12th.
by NC 34 Staff / Jan 15, 2021
BINGHAMTON, NY - Locally now, certain student-athletes on the SUNY Broome campus will be able to return to the field soon.
On Tuesday, the school announced that baseball, softball, tennis, and ESports will all be eligible to play this spring.
Buffalo Kickoff Live: Jan. 15
We're back with a Friday night addition of Buffalo Kickoff Live!
The Bills are hosting Lamar Jackson and company tomorrow night at Bills Stadium. It's set to be a chilly one with some possible snow in the forecast! | {
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Q: Ошибка в преоброзавании строки в float Console.WriteLine("Выберите коэфицент - от 1.1x до 3x");
float k = Convert.ToSingle(Console.ReadLine());
После того как я ввёл значение с точкой (например 1.5) получается ошибка
"Unhandled exception. System.FormatException: Input string was not in a correct format."
| {
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Our Version of Events — the debut album from Capitol Records' artist Emeli Sandé — debuted on the UK Album Chart at No. 1 this week. Due for release in the U.S. on June 5th, Our Version of Events is a powerful platform for Sandé's rich, soulful voice and sophisticated songwriting. As Q magazine put it: "She's made an album that deserves to linger in the limelight — passionate, powerful, and possessed of real star quality." A heady and complex soundscape to showcase her towering talent, Our Version of Events is rife with raw emotion, while bearing a sharp and shining retro-futurist feel.
Sandé will make her North American live debut with a string of stateside showcases beginning Monday, February 27th. In addition to private shows in New York City and Los Angeles, she will perform for the public in San Francisco, Minneapolis, and Toronto before returning to the U.S. this summer to open a series of arena shows for her Capitol Records' label mates Coldplay, whom she toured with in the UK in December.
The Scottish-born singer and songwriter won the 2012 Critics Choice Award at the BRITs (recent winners include Adele and Florence + the Machine) and was also nominated for "Breakthrough British Artist" this year. Besides the industry embrace, critical acclaim, and radio success she's already earned in the UK, Sandé's fellow artists are also lining up. With Coldplay tapping her for opening slots on both sides of the Atlantic, other early admirers include Alicia Keys who has been quoted saying "She's a magnificent new artist…I just love her style and her flow." Keys also co-wrote and produced the track "Hope" on Our Version of Events and has been writing with Sandé for her next album. Finally Adele was moved to Tweet "How incredible is she?" upon seeing Sandé perform on Later…with Jools Holland.
An intro reminiscent of an operatic nightmare with wandering time signatures and high voltage theatrics kicks off Fun's sophomore album by saying welcome to Some Nights, a world all in itself. Like a Freddy Mercury reincarnate with the backup choir from Paul Simon's, Graceland, Fun's lead singer, Nate Ruess let's his modern day vocal chops shine through in the very catchy song, "Some Nights." The next track, "We Are Young," featuring Janelle Monae, showcases the radio friendly sound of album producers Jeff Bhasker and Emile Haynie. With these two behind them and the band's wide range of influences including Elton John and Queen, Kanye West and Paul Simon, Fun takes its listeners on a hook-fueled journey.
"Carry On" brings in the Irish pub vibe until the guitar solo from Jack Antonoff kicks in. "It Gets Better" picks up the pace with pop rock that was as "effortless" to write as it sounds, according to the band. The same couldn't be said for "All Alright," which was the last song to be written on the album due to being denied use of a sample as their hook. Luckily Emile saved them from the arduous process of starting over from scratch by handing over an original beat. That instance aside, some songs may have been better off less produced such as "Why Am I the One?" which was intended to be an acoustic song from the onset (or Nate's highly vocoded vocals throughout the album and especially overdone in the closing track "Out of Town").
All in all Fun's Some Nights makes for a simple party concoction with vocal heavy rock compositions mixing with the bouncy dance driven singles. There is a cohesive anthemic energy evoking memories of summers long gone and child's play emitting from this album. Taking inspiration from everyday life and the artistic greats of many generations, this young songwriting trio delivers a solid second go around that is equal parts hip hop and indie rock, bubble gum pop and dance music with Some Nights, and quite possibly a song of the summer.
Dance-rock trio Turing Machine have announced the release of their first album in eight years, What Is The Meaning Of What, set for release May 8 on Temporary Residence Ltd. The extended hiatus that ensued following the release of their critically-acclaimed 2004 album Zwei was in large part due to drummer Jerry Fuchs' run of high profile collaborations with !!!, Maserati, The Juan Maclean, LCD Soundsystem, Holy Ghost!, MSTRKRFT, and Massive Attack, amongst others. Recording for What Is The Meaning Of What began in 2008, but came to a halt following Fuchs' tragic death in an elevator accident in Brooklyn, NY. After revisiting the tracks, Turing Machine's remaining members, guitarist Justin Chearno and bassist Scott DeSimon, went into the Brooklyn studios of producers Andrew Raposo (Midnight Magic) and Abe Seiferth to finish writing and recording the record. Over the course of 2011 they called on a plethora of friends to contribute, LCD Soundsystem's Pat Mahoney, Disappears vocalist Brian Case and a host of musicians from the DFA roster, including Abe Seiferth, DJ McNany and Caito Sanchez (Midnight Magic).
What Is The Meaning Of What ups the ante on the uptempo psychedelic post-punk fetishism of Zwei, boasting seven tracks of forceful dance-floor rock anthems. Propelled by Fuchs' unrelenting grooves and bubbling with layer upon layer of hypnotic riffs, the album locks in its target (your hips) and refuses to let go for its 40-minute duration. Check out the full track list and album art below.
Paul Weller returns this spring for his only scheduled appearances in North America this year. Weller and his band will perform at a two-night stand at the Best Buy Theater in Times Square, New York on May 18th & 19th.
His New York shows will be in support of Sonik Kicks, which is scheduled for release on March 27th 2012 on Yep Roc Records. The album is the follow up to the Mercury Prize Award nominated Wake Up The Nation and is also Paul's eleventh solo album.
Swedish electro-pop group Lo-Fi-Fnk has announced the release of single "Kissing Taste," out next week featuring remixes by Main Attrakionz, Krusha, Lemaitre and more. Premiered at Stereogum, the video "features the group's Leo Drougge and August Hellsing (as well as other nice-looking Scandanavian youths) making the most of a snowy, smoky lost day as it winds down." Lo-Fi-Fnk has also premiered the Krusha remix of the single, with the original track taken from their Last Summer LP.
Late last year, Lo-Fi-Fnk embarked on a North American tour with Architecture in Helsinki and DOM. They released their debut Boylife LP with Moshi Moshi in 2006, a confection of sharp melodies, beats and clever lyrics, with tracks highlighted on Stereogum, Pitchfork, NME, It's a Trap, Discobelle, and many more. Since then, they've remixed and been remixed by artists including Yelle, Architecture in Helsinki, Foster the People, The Radio Dept., C asiokids, and Mika among others. Touring the world the two have shared the stage with Hot Chip, Crystal Castles, Junior Boys and Datarock & The Presets.
Psychedelic "Off The Wall" Video Out Today!
French electro-pop composer Yuksek (aka Pierre-Alexander Busson) released his new album, Living On The Edge Of Time, February 14 on Ultra Records. Combining the infectious house beats and dance-floor vibe that Pierre has perfected with a more straightforward pop sound, the album has gained widespread praise from the likes of USA Today and CMJ, among others. Today, Yuksek released a psychedelic video for album track "Off The Wall." The playful video brings the bouncy, upbeat track to life with images of mirrored body parts moving along to the beat and giant faces built of colorful paper cutouts. Head to Dailymotion to check out the creative "Off The Wall" video and feel free to post and share!
On Living On The Edge Of Time, Yuksek's melodic vocals shine over catchy hooks and toe-tapping beats. Opening track "Always On The Run" grabs listeners from the start, setting an energetic tone for the rest of the album. "On A Train" is a true dance-floor anthem, building to an explosive chorus that will get stuck in your head for days. "White Keys" is marked by a synth melody that is featured throughout, setting a more contemplative mood. Closing the record is psych-pop track "Out Of Control," complete with finger snaps and driving bass.
Having already made quite an impression in North America, Yuksek's US fans will have more chances to catch the master of electro-pop performing live. Yuksek will head out on a string of US dates this March, including several performances at SXSW and Winter Music Conference. Be sure to catch the band unleash a tour de force live in a city near you!
It's very simple; no one can get enough of Brad Oberhofer. He broke out with the fresh sound that everyone had been craving to hear. Now, this Tacoma bred-Brooklyn based artist is rollin' with the core music crowd and gaining notoriety by the day. Luckily, you can catch him at the Bowery Ballroom March 21st. Every one of your pennies would be worth it.
What's the difference between Washington State's versus Brooklyn's music scene?
Oberhofer: I think Brooklyn's music scene is just more expansive! There are so many places to play, so many neighborhoods to hang out in, and more potential friends!
You blew up after the release of o0Oo0Oo. Were you surprised at how quickly everything evolved?
Oberhofer: I don't think I really noticed!
So you play all the instruments separately on your album?
Oberhofer: Mostly. The rest of the band plays on the record too! Matt Scheiner plays some guitar parts, Dylan Treleven plays some bass, and Pete Sustarsic plays drums. I also had my friend Kristine Kruta play cello, my friend Tessa Sacramone play violin, my friend Cicourel Hanly play Oboe, and my friend Natalie Young play flute. (Steve Lillywhite played a percussion track here and there. They're all super talented.
I read you started playing music in 4th grade. From that point on, did you always know you wanted to be a professional musician?
Oberhofer: No, it took a while!
I also read you used to freestyle rap. Would you ever incorporate any freestyling/hip-hop elements into future tracks?
Oberhofer: Maybe, I haven't tried yet!
You have recorded some beautiful love songs. Is that one of the main themes present in your music?
Oberhofer: I love a lot of things, I figure it must.
My friend told me about the epic time when you performed a cover of Kanye's Runaway at Spotify's show at Mercury Lounge. Are you ever going to release that version?
Congrats on Coachella! What an honor….On a scale from 1-10, how excited are you to perform at the festival?
I always ask a random question, do you have a favorite karaoke song?
Oberhofer: I don't pick favorites, but I did Space Oddity the other night and it felt really nice.
They've been popping up like wildfire nowadays: folk/pop songwriters that sing with a quasi-profound, heart-on-sleeve air. They attempt to affect a "deeper" musical experience than the typical Top-40 radio fare provides, and yet somehow end up making it to the Top-40 anyways. Of course, this approach is nothing new to The Fray, who have built a career around songs like "How To Save a Life," an anthem for Kiss FM listeners trying and/or pretending to have a refined taste.
I shouldn't be so hard on the band. There are some light moments dispersed here and there. After "The Fighter" chugs along for about 2 minutes and 30 seconds, the song quiets as the band fades, evoking elements utilized by bands like The Rocketboys. As the momentum builds again, the key shifts higher but is matched with a low note on the piano while lead singer Isaac Slade sings, "The lover held her love / She begged him not go." He continues, "Somehow they both know / He's not coming home," keenly capturing the emotional intimacy of a couple that has mutually realized the end of their romance.
And it is refreshing to hear any artist convey the beliefs that shape their art, like the band does in "Be Still", even if they do try to inconspicuously mask what they are really talking about (Do they really think the listeners are not going to pick up on who's talking when it says, "When darkness comes upon you / And covers you with fear and shame / Be still and know that I am with you"?), all the while denying any allegations of being a "Christian" band.
For as many eye-rolls and dismissals one might suffer in the company of high-browed hipsters when name-dropping The Fray, it is difficult not to move, albeit reluctantly for some, when their songs play. That's probably the point.
As a follow up to their latest LP, Blood Pressures, The Kills have released an EP, The Last Goodbye. The album begins with a reprisal of their most well-received song by the same name, a track gushing with emotion reminiscent of Duffy's "Warwick Avenue." Only instead of a blonde with Motown influenced vocals you've got VV singing with the dark and moody ruggedness of a 1980's heroin high in Tompkins Square Park. It's a haunting melody that will interrupt your dreams for days and a lyrical line that resonates with anyone who's ever had to begrudgingly bid farewell to an unhealthy love.
Then you'll hear the covers. Fitting right in with the ambience created in the title track is the second song, "Pale Blue Eyes," made famous by The Velvet Underground decades ago and still a staple in the late night bar scene. Fortunately The Kills balance the acts of paying homage to the original vocal performance and stepping it up a couple notches of intensity with a simple but heavy drum beat combined with a sleepy garage rock sound on guitar.
Next on the list is "One Silver Dollar" where VV shows the lighter side. Sticking with the acoustic nature of the original as performed by Marilyn Monroe, The Kills hold true to their somewhat sullen sound but cut back the edge on this one. Like a bridge after two dark verses, "One Silver Dollar" lightens the EP up just before delving back into the abyss of heartache. Winding down the EP with a jukebox favorite and popular cover song, "Crazy" fits right into the theme of The Last Goodbye as a suitable closing for one very lovesick ride. | {
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Research policies and scientific production: A study of 94 Peruvian universities
Pablo Alejandro Millones-Gómez, Judith Soledad Yangali-Vicente, Claudia Milagros Arispe-Alburqueque, Oriana Rivera-Lozada, Kriss Melody Calla-Vásquez, Roger Damaso Calla-Poma, Margarita Fe Requena-Mendizábal, Carlos Alberto Minchón-Medina
Biotecnología estomatológica
Studies of research policies and scientific production are essential for strengthening educational systems and achieving objectives such as quality improvement. The aim of this study was to evaluate the influence of research policies on the scientific production of public and private Peruvian universities. An observational, descriptive, secondary analysis study of the research policies of 92 universities and two graduate schools licensed by the National Superintendence of Higher Education of Peru (SUNEDU) was conducted for the period from 2016–2020. Scientific publications from educational institutions were collected from Scopus and Web of Science for the study period, and researchers certified by the National Council of Science and Technology of Peru (CONCYTEC) were divided by group and level. Multiple regression analysis was performed using two models. The analysis indicated that research policies did not influence scientific production in Scopus or Web of Science in either 2019 or 2020 (Model I) but that type of management (p < 0.01), number of National Scientific, Technological, and Technological Innovation Registry (RENACYT) researchers (p < 0.001) and 2016 scientific production (p < 0.001) did influence production when these variables were incorporated into the model (Model II). However, time of licensing and management type had no effects. The number of research policies implemented by Peruvian universities and licensed graduate schools was not large. Therefore, it is recommended that project funding policies, research training, and research collaboration be strengthened and that the management capacity of research centers and institutes be increased.
Funding: This work was funded by grants from Universidad Norbert Wiener (https://www.uwiener.edu.pe/) (076-2020-R-UPNW (PMG)). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
© 2021 Millones-Gómez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Dive into the research topics of 'Research policies and scientific production: A study of 94 Peruvian universities'. Together they form a unique fingerprint.
research policy Agriculture & Biology 100%
Peru Agriculture & Biology 21%
regression analysis Agriculture & Biology 17%
researchers Agriculture & Biology 16%
higher education Agriculture & Biology 14%
educational institutions Agriculture & Biology 14%
funding Agriculture & Biology 11%
Millones-Gómez, P. A., Yangali-Vicente, J. S., Arispe-Alburqueque, C. M., Rivera-Lozada, O., Calla-Vásquez, K. M., Calla-Poma, R. D., Requena-Mendizábal, M. F., & Minchón-Medina, C. A. (2021). Research policies and scientific production: A study of 94 Peruvian universities. PLoS ONE, 16(5 May), [e0252410]. https://doi.org/10.1371/journal.pone.0252410
Millones-Gómez, Pablo Alejandro ; Yangali-Vicente, Judith Soledad ; Arispe-Alburqueque, Claudia Milagros ; Rivera-Lozada, Oriana ; Calla-Vásquez, Kriss Melody ; Calla-Poma, Roger Damaso ; Requena-Mendizábal, Margarita Fe ; Minchón-Medina, Carlos Alberto. / Research policies and scientific production : A study of 94 Peruvian universities. In: PLoS ONE. 2021 ; Vol. 16, No. 5 May.
@article{f5c325bd22e845558c7cddf65cd88448,
title = "Research policies and scientific production: A study of 94 Peruvian universities",
abstract = "Studies of research policies and scientific production are essential for strengthening educational systems and achieving objectives such as quality improvement. The aim of this study was to evaluate the influence of research policies on the scientific production of public and private Peruvian universities. An observational, descriptive, secondary analysis study of the research policies of 92 universities and two graduate schools licensed by the National Superintendence of Higher Education of Peru (SUNEDU) was conducted for the period from 2016–2020. Scientific publications from educational institutions were collected from Scopus and Web of Science for the study period, and researchers certified by the National Council of Science and Technology of Peru (CONCYTEC) were divided by group and level. Multiple regression analysis was performed using two models. The analysis indicated that research policies did not influence scientific production in Scopus or Web of Science in either 2019 or 2020 (Model I) but that type of management (p < 0.01), number of National Scientific, Technological, and Technological Innovation Registry (RENACYT) researchers (p < 0.001) and 2016 scientific production (p < 0.001) did influence production when these variables were incorporated into the model (Model II). However, time of licensing and management type had no effects. The number of research policies implemented by Peruvian universities and licensed graduate schools was not large. Therefore, it is recommended that project funding policies, research training, and research collaboration be strengthened and that the management capacity of research centers and institutes be increased.",
author = "Millones-G{\'o}mez, {Pablo Alejandro} and Yangali-Vicente, {Judith Soledad} and Arispe-Alburqueque, {Claudia Milagros} and Oriana Rivera-Lozada and Calla-V{\'a}squez, {Kriss Melody} and Calla-Poma, {Roger Damaso} and Requena-Mendiz{\'a}bal, {Margarita Fe} and Minch{\'o}n-Medina, {Carlos Alberto}",
note = "Publisher Copyright: {\textcopyright} 2021 Millones-G{\'o}mez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
number = "5 May",
Millones-Gómez, PA, Yangali-Vicente, JS, Arispe-Alburqueque, CM, Rivera-Lozada, O, Calla-Vásquez, KM, Calla-Poma, RD, Requena-Mendizábal, MF & Minchón-Medina, CA 2021, 'Research policies and scientific production: A study of 94 Peruvian universities', PLoS ONE, vol. 16, no. 5 May, e0252410. https://doi.org/10.1371/journal.pone.0252410
Research policies and scientific production : A study of 94 Peruvian universities. / Millones-Gómez, Pablo Alejandro; Yangali-Vicente, Judith Soledad; Arispe-Alburqueque, Claudia Milagros; Rivera-Lozada, Oriana; Calla-Vásquez, Kriss Melody; Calla-Poma, Roger Damaso; Requena-Mendizábal, Margarita Fe; Minchón-Medina, Carlos Alberto.
In: PLoS ONE, Vol. 16, No. 5 May, e0252410, 05.2021.
T1 - Research policies and scientific production
T2 - A study of 94 Peruvian universities
AU - Millones-Gómez, Pablo Alejandro
AU - Yangali-Vicente, Judith Soledad
AU - Arispe-Alburqueque, Claudia Milagros
AU - Rivera-Lozada, Oriana
AU - Calla-Vásquez, Kriss Melody
AU - Calla-Poma, Roger Damaso
AU - Requena-Mendizábal, Margarita Fe
AU - Minchón-Medina, Carlos Alberto
N1 - Publisher Copyright: © 2021 Millones-Gómez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
N2 - Studies of research policies and scientific production are essential for strengthening educational systems and achieving objectives such as quality improvement. The aim of this study was to evaluate the influence of research policies on the scientific production of public and private Peruvian universities. An observational, descriptive, secondary analysis study of the research policies of 92 universities and two graduate schools licensed by the National Superintendence of Higher Education of Peru (SUNEDU) was conducted for the period from 2016–2020. Scientific publications from educational institutions were collected from Scopus and Web of Science for the study period, and researchers certified by the National Council of Science and Technology of Peru (CONCYTEC) were divided by group and level. Multiple regression analysis was performed using two models. The analysis indicated that research policies did not influence scientific production in Scopus or Web of Science in either 2019 or 2020 (Model I) but that type of management (p < 0.01), number of National Scientific, Technological, and Technological Innovation Registry (RENACYT) researchers (p < 0.001) and 2016 scientific production (p < 0.001) did influence production when these variables were incorporated into the model (Model II). However, time of licensing and management type had no effects. The number of research policies implemented by Peruvian universities and licensed graduate schools was not large. Therefore, it is recommended that project funding policies, research training, and research collaboration be strengthened and that the management capacity of research centers and institutes be increased.
AB - Studies of research policies and scientific production are essential for strengthening educational systems and achieving objectives such as quality improvement. The aim of this study was to evaluate the influence of research policies on the scientific production of public and private Peruvian universities. An observational, descriptive, secondary analysis study of the research policies of 92 universities and two graduate schools licensed by the National Superintendence of Higher Education of Peru (SUNEDU) was conducted for the period from 2016–2020. Scientific publications from educational institutions were collected from Scopus and Web of Science for the study period, and researchers certified by the National Council of Science and Technology of Peru (CONCYTEC) were divided by group and level. Multiple regression analysis was performed using two models. The analysis indicated that research policies did not influence scientific production in Scopus or Web of Science in either 2019 or 2020 (Model I) but that type of management (p < 0.01), number of National Scientific, Technological, and Technological Innovation Registry (RENACYT) researchers (p < 0.001) and 2016 scientific production (p < 0.001) did influence production when these variables were incorporated into the model (Model II). However, time of licensing and management type had no effects. The number of research policies implemented by Peruvian universities and licensed graduate schools was not large. Therefore, it is recommended that project funding policies, research training, and research collaboration be strengthened and that the management capacity of research centers and institutes be increased.
IS - 5 May
M1 - e0252410
Millones-Gómez PA, Yangali-Vicente JS, Arispe-Alburqueque CM, Rivera-Lozada O, Calla-Vásquez KM, Calla-Poma RD et al. Research policies and scientific production: A study of 94 Peruvian universities. PLoS ONE. 2021 May;16(5 May). e0252410. https://doi.org/10.1371/journal.pone.0252410 | {
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Not every used vehicle on the lot comes with the Toyota Certified Used Vehicle distinction, but the ones that do can be purchased with the knowledge that they are the cream of the crop when it comes to choosing a pre-owned vehicle. While we stand confidently by all of our vehicles, and they all pass our own internal inspection, these select Toyotas have passed an additional rigorous 160 point inspection to earn this distinction and all the benefits that come with it.
Toyotas are phenomenal machines, and they tend to hold their value regardless, but once they have passed the Toyota Certified Used inspection it qualifies for a host of additional benefits that come right from the manufacturer. These benefits include, but are certainly not limited to, 6-10 month/ 10,000km Powertrain and Roadside Assistance Coverage, zero deductible, extensive mechanical and appearance reconditioning, a full carfax report, a complimentary first oil and filter change and a guarantee of satisfaction up to seven days or 1,500 km, and that is all on top of our own programs and guarantees.
Let's face it, in today's busy world – things happen. But, with service available 24 hours a day, 365 days a year, Toyota's got you covered. From the day you purchase your Certified Toyota or Scion, you receive one year of Roadside Assistance virtually anywhere across the United States and Canada 2. Happy trails! | {
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Женская сборная Дании по кёрлингу — представляет Данию на международных соревнованиях по кёрлингу. Управляющей организацией выступает Ассоциация кёрлинга Дании (, ).
Статистика выступлений
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Мужская сборная Дании по кёрлингу
Смешанная сборная Дании по кёрлингу
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Сборная Дании по кёрлингу на колясках
Смешанная парная сборная Дании по кёрлингу на колясках
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Дания -- Раздел результатов и статистики на сайте WCF
Официальный сайт Ассоциации кёрлинга Дании
Дания
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Aluminium Alloy 5754 H111 Sheets has excellent corrosion resistance especially to seawater and industrially polluted atmospheres. It has higher strength and is typically used in ship building, vehicle bodies, fishing equipments. It displays excellent weldability and average machinability. Plus Metal supplies an unrivalled quality of Aluminum Alloy 5754 H111 sheets, that are durable and serve their purpose.
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AT&T Moves Further From vMVPD Model With New Price Hikes
Monday, October 21, 2019, 12:23 PM ET
AT&T is moving further away from the low-cost virtual MVPD ("skinny bundle") model it helped pioneer with DirecTV Now back when it launched in 2016. Per multiple reports on Friday, AT&T will increase the monthly price of its "Plus" tier by $15 (to $65 per month) and its "Max" tier by $10 (to $80 per month) in November.
This past summer AT&T rebranded DirecTV Now as AT&T TV Now. DirecTV Now had already imposed a $10 per month price hike back in March and consolidated DirecTV Now's original 3 tiers into the 2 current tiers and included HBO with both of them. If you were to back out the $15 per month that a standalone HBO Now subscription would cost, then the "Plus" and "Max" tiers would be $50 per month and $70 per month, respectively.
Those rates are essentially in line for comparable vMVPD services like YouTube TV ($50 per month), Hulu with Live TV ($45 per month), fuboTV ($55 per month) or PlayStation Vue ($55 per month for Core tier). All of these services include the major broadcast TV networks and a lot of other overlapping content. Other features vary between the services, such as YouTube TV's unlimited DVR, and Hulu's SVOD library.
The earlier price increase, coupled with a dramatic slowdown in discount promotions and rising competition had already driven down DirecTV Now subscribers by 168K subscribers in Q2 '19. That brought DirecTV Now's total losses for the prior 4 quarters to 469K subscribers.
There's no doubt the new moves will cause more subscriber contraction, as AT&T moves steadily away from the low-cost virtual MVPD model that was its primary initial appeal. High programming costs always meant that turning a profit on vMVPD services was going to be challenging. At one time these seemed palatable as a way of bolstering wireless subscribers (I called it the "video as bait" strategy) and offsetting losses from AT&T's traditional MVPDs U-verse and DirecTV.
But AT&T massive debt load, incurred from the Time Warner acquisition, has reduced the company's flexibility to absorb short-term losses (not to mention an activist investor campaign against the company which could lead to the spin-off of DirecTV entirely). Two other new services, AT&T TV (the OTT-delivered DirecTV alternative) and HBO Max (the SVOD service launching next spring) will likely become the company's core bundling methods for wireless.
DirecTV Now / AT&T TV Now had a quick 3 year evolution from golden child to unloved orphan. When AT&T reports its Q3 '19 results next Monday, we'll get another update on its falling trajectory.
Categories: Skinny Bundles, Telcos
Topics: AT&T, DirecTV Now
Related VideoNuze Analysis
VideoNuze Podcast #476: Can AT&T Put Its Video Puzzle Pieces Together?
AT&T Lost Over 1.1 Million Video Subscribers in Q4 '19; Nearly 20% of Base in Past 2 Years | {
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Stephanie Tyler
Executive Director of External Affairs, AT&T Western Region
Stephanie Tyler serves as the President of AT&T Nevada as well as overseeing the External Affairs operations of a 14-state western region. In this role, she manages the state and local government relations, community affairs, regulatory and legislative activities. Stephanie's 18-year AT&T career in External Affairs includes five years in California and the last 13 in the Western Region. In 2003, she took a one-year leave of absence at the request of California Governor Arnold Schwarzenegger to serve as the Political Director to his successful re-election campaign.
Prior to joining AT&T in 1990, Stephanie was appointed to fill a vacancy in the Nevada State Senate representing northern Nevada. She has been actively involved with numerous community boards and commissions in both Reno and Las Vegas. A native Nevadan, Stephanie spent the early years of her career in a variety of political roles including serving on the staff of U.S. Senator Paul Laxalt in Washington D.C. and in his local district offices. Stephanie is a graduate of the University of Nevada, Reno with a degree in political science. She has a gift for humor and is always willing to share her knowledge and experience to grow her team and the leaders around her. | {
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