Резюме. Обзор посвящен вирусу краснухи, его тератогенному действию; описанию синдрома врожденной краснухи (СВК), современных методов диагностики и профилактики инфекции. Настоящее сообщение освещает современные представления о структурно-функциональной организации Rubella virus (род Rubivirus, семейство Togaviridae), этапах репродукции вируса.
1. Анджапаридзе О.Г., Червонский Г.И. Краснуха. — Москва, 1975. — 102 с.
2. Вирусология: пер. с англ. / Под ред. Б. Филда, Д. Найпа. — М.: Мир, 1989. — Т. 2. — 494 c.
3. Гайдамович С.Я., Логинова Н.В. Общая и частная вирусология / Под ред. В.М. Жданова, С.Я. Гайдамович — М.: Медицина, 1986. — Т. 2. — С. 49–95.
4. Лаврентьева И.Н. Штамм «Орлов-Д» для получения живой аттенуированной вакцины против краснухи: Дис. ... д-ра мед. наук. — СПб., 2009. — 328 с.
5. Львов Д.К., Урываев Л.В. Тогавирусы (Togaviridae) // Медицинская вирусология: Руководство; под ред. Д.К. Львова. — М.: ООО «Медицинс кое информационное агентство», 2008. — С. 217–224.
6. Львов Д.К., Урываев Л.В. Краснуха // Медицинская вирусология: Руководство; под. ред. Д.К. Львова. — М: ООО «Медицинское информационное агенство», 2008. — 447–450 с.
7. Семериков В.В., Лаврентьева И.Н., Таточенко В.К., Нисевич Л.Л., Фельдблюм И.В., Краснуха. — Пермь–СПб.–М.: ИПК «Звезда», 2002. — 175 с.
8. Atreya C.D., Kulkarni S., Mohan K.V. Rubella virus P90 associated with cytokinesis regulatory protein Citron-k kinase and the viral infection and constitutive expression of 90 protein both induce cell cycle arrest following S phase in the cell culture // Arch. Virol. — 2004. — Vol. 149, N 4. — P. 779–789.
9. Bardeletti G., Tektoff J., Gautheron D. Rubella Virus maturation and production in two host cell systems // Intervirology. — 1979. — Vol. 11, N 2. — P. 97–103.
10. Baron M.D., Ebel T., Suomalainen M. Intracellular transport of rubella virus structural proteins expressed from cloned cDNA // J. Gen. Virol. — 1992. — Vol. 73. — P. 1073–1086.
11. Baron M.D., Forsell K. Oligomerization of the structural proteins of rubella virus // Virology. — 1991. — Vol. 185. — P. 811–819.
12. Beatch M.D., Hobman T.C. Rubella virus capsid associates with host cell protein p32 and localizes to mitochondria // J. Virol. — 2000. — Vol. 74, N 12. — P. 5569–5576.
13. Chaye H.H., Mauracher C.A., Tingle A.J., Gillam S. Cellular and humoral immune responses to rubella virus structural proteins E1, E2 and C // J. Clin. Virol. —1992. — Vol. 30, N 9. — P. 2323–2329.
14. Chaye H.H., Chong P., Tripet B., Brush B., Gillam S. Localization of the virus neutralizing and hemagglutinin epitopes of E1 glycoprotein of rubella virus // Virology. — 1992. — Vol. 189. — P. 483–492.
15. Chen M.H. Rubella v 15. virus capcid protein modulates viral genome replication and virus infectivity // J. Virol. — 2004. — Vol. 78, N 8. — P. 4314–4322.
16. Clark D.M., Loo T.W., McDonald H., Gillam S. Expression of rubella virus cDNA coding for the structural proteins // Gene. — 1988. — Vol. 65. — P. 23–30.
17. Clarke D.M., Loo T.W., Hui I., Chong P., Gillam S. Nucleotide sequence and in vitro expression of rubella virus 24S subgenomic messenger RNA encoding the structural proteins E1, E2 and C // Nucleic Acids Research. — 1987. — Vol. 15, N 7. — P. 3041–3056.
18. Claus C., Hofmann J., Überla K., Liebert U.G. Rubella virus pseudotypes and cell-cell fusion assay as tools for functional analysis of the rubella virus E2 and E1 envelope glycoproteins // J. Gen. Virol. — 2006. — Vol. 87. — P. 3029–3037.
19. Corboba P., Grutadauria S., Cuffini C., Zapata M. Neutralizing monoclonal antibody to the E1 glycoprotein epitopeof rubella virus mediates virus arrest in vero cells // Viral. Immunol. — 2000. — Vol. 13, N 1. — P. 83–92.
20. Dominguez C., Wang C.Y., Frey T.K. Sequence of the genome RNA of Rubella virus: evidence for genetic rearrangement during togavirus evolution // Virology. — 1990. — N 177. — P. 225–238.
21. Duncan R., Esmaili A., Law L., Bertholet S., Hobman T., Nakhasi H. RUBV capsid protein induces apoptosis in transfected RK 13 cells // Virology. — 2000. — Vol. 275. — P. 20–29.
22. Fontana J., López-Iglesias C., Tzenh W.-P., Frey T.K., Fernández J.J., Risco C. Three-dimensional structure of Rubella virus factories // Virology. — 2010. — Vol. 405, N 2. — P. 579–591.
23. Forng R.J., Frey T.K. Identification of the Rubella virus nonstructural proteins // Virology. — 1995. — Vol. 206. — P. 843–853.
24. Forng R.J., Atreya C.D. Mutations in the retinoblastoma protein-binding LXCXE motif of rubella virus putative replicase affect virus replication // J. Gen. Virol. — 1999. — Vol. 80. — P. 327–332.
25. Frey T.K. Molecular biology of RUBV // Adv. Virus Res. — 1994. — Vol. 44. — P. 69–160.
26. Frey T.K., Marr L.D. Sequence of the region coding for virions proteins C and E2 and the carboxy terminus of the nonstructural proteins of rubella virus: comparison with alphaviruses // Gene. — 1988. — Vol. 62. — P. 85–99.
27. Fundamental virology // Chief Edition B.N. Fields, D.M. Knipe. — N.Y., 1989. — Vol. 2. — P. 344–346.
28. Garbutt M., Law L.M., Chan H., Horban T.C. Role of rubella virus domains in assembly of virus-like particles // J. Virol. — 1999. — Vol. 73. — P. 3524–3533.
29. Hobman T.C., Gillam S. In vitro and in vivo expression of rubella virus glycoprotein E2: the signal peptide is contained in the C-terminal region of capsid protein // Virology. — 1989. — Vol. 173. — P. 241–250.
30. Horban T.C., Lundstrem M.L., Gillam S. Processing and intracellular transport of rubella virus structure protein in COS cells // Virology. — 1990. — Vol. 78. — P. 122–123.
31. Kujala P. Intracellular distribution of rubella virus nonstructural protein 150 // J. Virol. — 1999. — Vol. 73, N 9. — P. 7805–7811.
32. Lee J.Y., Marshall J.A., Bowden D.S. Localization of rubella virus core particles in vero cells // Virology. — 1999. — Vol. 265, N. 1. — Р. 110–119.
33. Lee J.-Y., Bowden D.S. Rubella virus replication and links to teratogenicity // Clin. Microbiol. Rev. — 2000. — Vol. 13, N 4. — P. 571–587.
34. Liang Y., Giilam S. Mutational analysis of the rubella virus nonstructural polyprotein and its cleavage products in virus replication and RNA synthesis // J. Virol. — 2000. — Vol. 74, N 11. — P. 5133–5141.
35. Liang Y., Yao J., Gillam S. Rubella virus nonstructural protein protease domains involved in trans- and cyscleavage activities // J. Virol. — 2000. — Vol. 74, N 12. — P. 5412–5423.
36. Liu Z.Y., Qui Z., Lim K.T., Chong P., Gillam S. Identification of domains in RUBV genomic RNA and capsid protein necessary for scecific interaction// J. Virol. — 1996. — Vol. 70. — P. 2184–2190.
37. Marr L.D., Sanchez A., Frey T.K. Efficient in vitro translation and processing of rubella virus structural proteins in the presence of microsomes // Virology. — 1991. — Vol. 180. — P. 400–405.
38. Marr L.D., Wang C.-J., Frey T.K. Expression of the rubella virus nonstructural protein ORF and demonstration of proteolytic processing // Virology. — 1994. — Vol. 198. — P. 586–592.
39. Mastromarino P., Cioe L., Rieti S., Orsi N. Role of membrane phospholipids and glycolipids in the Vero cellssurface receptor for rubella virus // Med. Microbiol. Immunol. — 1990. — Vol. 179. — P. 105–114.
40. Mauracher C.A., Gillam S., Shukin R., Tingle A.J. pH-dependent solubility shift of rubella virus capsid protein // Virology. — 1991. — Vol. 181. – P. 773–777.
41. Menser M.A., Harley J.D., Hertzberg R., Dorman D.C., Murphy A.M. Persistence of virus in lens for three years after prenatal rubella // Lancet. — 1967. — Vol. 2, N 7512. — P. 387–388.
42. Menser M.A., Forrest J.M. Rubella — high incidence of defect in children concidered normal at birth // JAMA. — 1974. — Vol. 1. — P. 123–126.
43. Modin J.E., Brandling-Bennet A.D. Surveillance of Congenital Rubella Syndrom 1969–1973// Rev. Infect. Dis. — 1974. — Vol. 130. — P. 316–318.
44. Nakhasi H.L., Zheng D., Hewlett K., Liu T. RUBV replication: effect on interferon and actinomycin D // Virus Res. — 1988. — Vol. 10. — P. 1–15.
45. Oker-Blom C., Petterson R.F., Summers M.D. Baculovirus polyhedron promoter-directed expression of rubella virus envelope glycoproteins, E1 and E2, in Spodoptera frugiperda cells // Virology. — 1989. — Vol. 172, N 1. — P. 82–91.
46. Oker-Blom C., Ulmanen I., Kääriäinen L., Pettersson R.F. Rubella virus 40S genome RNA specifies a 24S subgenomic mRNA that encodes for a precursor to structural proteins// J. Virol. — 1984. — Vol. 49. — P. 403–408.
47. Oker-Blom C. The gene order for rubella virus structural proteins is NH2-C-E2-E1-COOH // J. Virol. — 1984. — Vol. 51. — P. 354–358.
48. Petruzziello R., Orsi N., Macchia S., Rieti S.W., Frey T.K., Mastromarino P. Pathway of rubella virus infectious entry into Vero cells //J. Gen. Virol. — 1996. — Vol. 77. — P. 303–308.
49. Peuvot J.A., Schanck L., Linds L., Brasseur R. Are the fussion processes involved in birth, life and death of he cell depending on tilted insertion of peptides into membranes? // J. Theoretic Biol. — 1999. — Vol. 198, N 2. — P. 173–181.
50. Suomalainen M.H., Garoff H., Baron M.D. The E2 signal sequence of rubella virus remains part of the capsid protein and confers membrane association in vitro // J. Virol. — 1990. — Vol. 64. — P. 5500–5509.
51. Terry G.M., Ho-Terry L., Rees K.R. Localization of rubella E1 epitopes // Arch. Virol. — 1988. — Vol. 98. — P. 189–197.
52. Tzeng W.P., Frey T.K. C-E1 fusion protein synthesized by rubella virus DI RNAs maintained during serial passage // Virology. — 2006. — Vol. 356, N 1–2. — P. 198–207.
53. Tzeng W.P., Frey T.K. Rubella virus capsid protein modulation of viral genomic and subgenomic RNA synthesis // Virology. — 2005. — Vol. 337, N 2. — P. 327–334.
54. Vaheri A., Sedwick W.D., Plotkin S.A. Grown of the rubella virus in BHK 21 cells. 1. Virus production and infectivity assays // Prok. Soc. Exp. Biol. (N.Y.). — 1967. — Vol. 125. — P. 1086–1092.
55. Webster W.S. Teratogen update: congenital rubella // Teratology. — 1998. — Vol. 58. — P. 13–23.
56. WHO. Standardization of the nomenclature for genetic characteristics of wild-type rubella viruses // Wkly Epidemiol. Rec. — 2005. — Vol. 80. — P. 126–132.
57. Yao J., Gillam S. A single-amino-acid substitution of a tyrosine residue in the rubella virus E1 cytoplasmic domain blocks virus release // J. Virol. — 2000. — Vol. 74, N 7. — Р. 3029–3036.
58. Yao J., Gillam S. Mutational analysis, using a fulllength rubella virus CAN clone, of rubella virus E1 transmembrane and cytoplasmic domains required virus release // J. Virol. — 1999. — Vol. 73. — P. 4622–4630.
59. Zheng D.-P., Katow Sh., Abernathy E.S., Song Ki-J., Xu W.-B., Yarulin V., Desjatskova R.G., Aboudy Y., Enders G., Croxson M. Global distribution of Rubella virus genotypes // Emerg. Infect. Dis. — 2003. — Vol. 9, N 12. — Р. 1523–1530.
60. Zheng D.-P. Update of standard nomenclature for wild-type rubella viruses, 2007 // Wkly Epidemiol. Rec. — 2007. — Vol. 82, N 4. — P. 216–222.
61. Zhou Y. Genomic analysis of diverse rubella virus genotypes / J. Gen. Virol. — 2007. — Vol. 88. — P. 932–941.