This article presents clinical outcomes in patients with chronic low back pain and concludes that Prolotherapy using a variety of proliferant solutions can be an effective treatment for low back pain when performed by a skilled practitioner.
In this retrospective study on the use of Hactkett-Hemwall dextrose Prolotherapy, patients who presented with over four years of unresolved low back pain were shown to improve their pain, stiffness, range of motion, and quality of life measures.
This review article discusses the common sources of low back pain, why MRI's can be misleading in diagnosing this kind of pain, and how and why Prolotherapy works.
This study showed that Prolotherapy can provide significant relief of low back pain as well as functional improvement even in "failed back syndrome".