This study was conducted by an international team of researchers led by Jiri Bartek, of the Danish Cancer Society Research Center in Copenhagen.
Previous studies have shown that the drug has anti-tumor activity both in vitro and in vivo. But as Bartek and colleagues explain in their paper, the drug hasn’t yet been repurposed for cancer treatment because the mechanism and molecular pathways through which the drug may act against cancer were unknown.
As the study’s authors explain, given the rising global incidence of cancer and the failure of many medications in the face of tumor resistance, identifying new possibilities for using already existing drugs is key.
So, Bartek and colleagues set out to unravel the mystery of disulfiram’s anticancer properties.
Patients with breast cancer, colorectal cancer, and prostate cancer all benefited from disulfiram’s effects.
“Our results help to explain the anticancer activity of the alcohol-abuse drug disulfiram,” say Bartek and his colleagues.
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