In a statement, the Louisville-based post-secondary education institution announced that it would focus its strategies locally on online learning.
The center opened in a Fort Mitchell office building two years ago.
"After being in the Northern Kentucky region for over two years, we have learned a great deal about what this region needs and wants. To that point, Sullivan has learned that the people in Northern Kentucky want more freedom and flexibility in pursuing their post-secondary education and training," a statement from the school said.
Northern Kentucky and southwest Ohio students will still be able to enroll at Sullivan through the university's online programs. "Students have clearly indicated this mode of delivery is their preference," the statement said.
Sullivan recently completed a merger with Spencerian College. The school has a strong presence in Louisville and Lexington.
"As Sullivan University has expanded outside its traditional markets of Louisville, Lexington, and Ft. Knox, we have learned that a more successful strategy is to focus on under-served education markets in smaller and more rural communities," the statement said. "That is why Sullivan has opened Centers for Learning in Louisa, in far eastern Kentucky, and Carlisle, in central Kentucky. In these places, business and community leaders approached Sullivan about locating to their communities. They also have provided facilities and other support to make our decisions easy.
"Sullivan University continues to explore other areas to expand throughout the state and region, including western and southern Kentucky, and other places not being adequately served by other colleges and universities."
The university said that it remains "very enthusiastic" about Northern Kentucky and Cincinnati, and that the region will continue "its rapid expansion."
"Sullivan looks forward to being part of that exciting time, and thank the people and businesses of the region for their warm reception of one of their newest neighbors," a statement said.